29.06.2017        SEMINAR

KFO296 MS & PREGNANCY | 16:15

Mounting evidence suggests that the required immune regulation during pregnancy is not simply a general ‘immunosuppressive state’, but modulates the way the adaptive immune system, specifically T cells, respond to self and foreign antigens. Intriguing clues to the importance of this immune modulation come from clinical observations in autoimmune diseases including multiple sclerosis (MS). Several studies have shown that inflammatory disease activity and risk for MS relapses decreases throughout pregnancy, but re-bounds after delivery. The aim of this project is to understand the mechanisms responsible for pregnancy mediated immune regulation and its benefit on maternal autoimmunity. Based on our preliminary data, we hypothesize that the pathways mediating tolerance against fetal antigens during pregnancy also affect responses against self-antigens, thereby ameliorating autoimmune diseases.

Standort: Campus Forschung N27 , Etage: EG, Raum: 0.14
16.15 bis 17.00 Uhr