Publikationen des Instituts für Klinische Pharmakologie und Toxikologie

  • Wirth J, Atzler D, di Giuseppe R, Cordts K, Menzel J, Böger RH, Boeing H, Eikert C, Schwedhelm E.
    Higher serum asymmetric dimethylarginine is related to higher risk of heart failure in the EPIC-Potsdam study.
    Amino Acids. 2017; 49: 173-182

    Moritz E, Wegner D, Groß S, Bahls M, Dörr M, Felix SB, Ittermann T, Oswald S, Nauck M, Friedrich N, Böger RH, Daum G, Schwedhelm E, Rauch BH.
    Data on subgroup specific baseline characteristics and serum sphingosine-1phosphate concentrations in the Study of Health in Pomerania.
    Data Brief. 2017; 12: 46-50

    Atzler D, McAndrew DJ, Cordts K, Schneider JE, Zervou S, Schwedhelm E, Neubauer S, Lygate CA. Dietary Supplementation with Homoarginine Preserves Cardiac Function in a Murine Model of Post-Myocardial Infarction Heart Failure.
    Circulation 2017; 135:400-402

    Schwafertz C, Schinner S, Kühn MC, Haase M, Asmus A, Mülders-Opgenoorth B, Ansurudeen I, Hornsby PJ, Morawietz H, Oetjen E, Schott M, Willenberg HS.
    Endothelial cell regulate β-catenin activity in adrenocortical cells via secretion of basic fibroblast growth factor.
    Mol Cell Endocrinol. 2017; 441: 108-115

    Lüneburg N, Siques P, Brito J, De La Cruz JJ, León-Verde F, Hannemann J, Ibanez C, Böger RH.
    Long-Term intermittent exposure to high altitude elevates asymmetric dimethylarginine in first exposed young adults.
    High Alt Med Biol. 2017; 18: 226-233

    Nilam M, Gribbon P, Reinshagen J, Cordts K, Schwedhelm E, Nau WM, Henning A.
    A Label-Free Continuous Fluorescence-Based Assay for Monitoring Ornithine Decarboxylase Activity with a Synthetic Putrescine Receptor.
    SLAS Discov. 2017:22; 906-914

    Xu X, Zhang P, Kwak D, Fassett J, Yue W, Atzler D, Hu X, Wang H, Lu Z, Guo H, Schwedhelm E, Böger RH, Chen P, Chen Y.
    Cardiomyocyte dimethylarginine dimethylaminohydrolase-1 (DDAH1) plays an important role in attenuating ventricular hypertrophy and dysfunction.
    Basic Res Cardiol. 2017; 112: 55

    Winkler MS, Kluge S, Holzmann M, Moritz E, Robbe L, Bauer A, Zahrte C, Priefler M, Schwedhelm E, Böger RH, Goetz AE, Nierhaus A, Zoellner C.
    Markers of nitric oxide are associated with sepsis severity: an observational study.
    Crit Care. 2017; 21: 189

    Kloth B, Pecha S, Moritz E, Schneeberger Y, Söhren KD, Schwedhelm E, Reichenspurner H, Eschenhagen T, Böger RH, Christ T, Stehr SN.
    AkrinorTM, a Cafedrine/ Theodrenaline Mixture (20:1), Increases Force of Contraction of Human Atrial Myocardium But Does Not Constrict Internal Mammary Artery In Vitro.
    Front Pharmacol. 2017; 8: 272

    Zewinger S, Kleber ME, Rohrer L, Lehmann M, Triem S, Jennings RT, Petrakis I, Dressel A, Lepper PM, Scharnagl H, Ritsch A, Thorand B, Heier M, Meisinger C, de Las Heras Gala T, Koenig W, Wagenpfeil S, Schwedhelm E, Böger RH, Laufs U, von Eckardstein A, Landmesser U, Lüscher TF, Fliser D, März W, Meinitzer A, Speer T.
    Symmetric dimethylarginine, high-density lipoproteins and cardiovascular disease.
    Eur Heart J. 2017; 38: 1597-1607

    Moritz E, Wegner D, Groß S, Bahls M, Dörr M, Felix SB, Ittermann T, Oswald S, Nauck M, Friedrich N, Böger RH, Daum G, Schwedhelm E, Rauch BH.
    Reference intervals for serum sphingosine-1-phosphate in the population-based Study of Health in Pomerania.
    Clin Chem Acta. 2017; 468:25-31

    Mels CMC, Schutte AE, Huisman HW, Smith W, Kruger R, van Rooyen JM, Schwedhelm E, Atzler D, Böger RH, Malan NT,
    Asymmetric dimethylarginine and symmetric dimethylarginine prospectively relates to carotid wall thickening in black men: the SABPA study.
    Amino Acids. 2017; 49: 1843-1853

    Winkler MS, Rissiek A, Priefler M, Schwedhelm E, Robbe L, Bauer A, Zahrte C, Zoellner C, Kluge S, Nierhaus A.
    Human leucocyte antigen (HLA-DR) gene expression is reduced in sepsis and correlates with impaired TNFα response: A diagnostic tool for immunosuppression?
    PLoS One 2017; 12: e0182427

    Rudolph TK, Fuchs A, Klinke A, Schlichting A, Frierichs K, Hellmich M, Mollenhauer M, Schwedhelm E, Baldus S, Rudolph V.
    Prasugrel as opposed to clopidogrel improves endothelial nitric oxide bioavailability and reduces platelet-leukocyte interaction in patients with unstable angina pectoris: A randomized controlled trial.
    Int J Cardiol. 2017; 248:7-13

    Börchers S, Babaei R, Klimpel C, Duque Escobar J, Schröder S, Blume R, Malik MNH, Oetjen E.
    TNFα-induced DLK activation contributes to apoptosis in the beta-cell line HIT.
    Naunyn Schmiedebergs Arch Pharmacol. 2017; 390: 813-825

    Harbaum L, Baaske KM, Simon M, Oqueka T, Sinning C, Glatzel A, Lüneburg N, Sydow K, Bokemeyer C, Klose H.
    Exploratory analysis of the neutrophil to lymphocyte ratio in patients with pulmonary arterial hypertension.
    BMC Pulm Med. 2017; 17: 72

  • Ramuschkat M, Appelbaum S, Atzler D, Zeller T, Bauer C, Ojeda FM, Sinning CR, Hoffmann B, Lackner KJ, Böger RH, Wild PS, Münzel T, Blankenberg S, Schwedhelm E, Schnabel RB, Gutenberg Health Study investigators.
    ADMA, subclinical changes and atrial fibrillation in the general population.
    Int J Cardiol. 2016; 203: 640-646

    Baum C, Johannsen SS, Zeller T, Atzler D, Ojeda FM, Wild PS, Sinning CR, Lackner KJ, Gori T, Schwedhelm E, Böger RH, Blankenberg S, Münzel T, Schnabel RB; Gutenberg Health Study investigators.
    ADMA and arginine derivatives in relation to non-invasive vascular function in ther general population.
    Atherosclerosis 2016; 244: 149-156

    Mels CM, Loots I, Schwedhelm E, Atzler D, Böger RH, Schutte AE.
    Nitric oxide synthesis capacity ambulatory blood pressure and end organ damage in a black and white population: the SABPA study.
    Amino Acids 2016; 48: 801-10

    Ittermann T, Bahls M, Atzler D, Friedrich N, Schwedhelm E, Böger RH, Felix RH, Völzke H, Dörr M. Derivatives Are Associated with the Hyperthyroid State in the General Population.
    Thyroid 2016; 26: 212-8

    Wallbach M, Duque Escobar J, Babaeikelishomi R, Stahnke MJ, Blume R, Schröder S, Kruegel J, Maedler K, Kluth O, Kehlenbach RH, Miosge N, Oetjen E.
    Distinct functions of the dual leucine zipper kinase depending on its subcellular localization.
    Cell Signal. 2016; 28: 272-83

    Oetjen E, Lemcke T.
    Dual leucine zipper kinase (MAP3K12) modulators: a patent review (2010-2015).
    Expert Opin Ther Pat. 2016; 26: 607-16

    Flenner F, Friedrich FW, Ungeheuer N, Christ T, Geertz B, Reischmann S, Wagner S, Stathopoulou K, Söhren KD, Weinberger F, Schwedhelm E, Cuello F, Maier LS, Eschenhagen T, Carrier L.
    Ranolazine antagonizes catecholamine-induced dysfunction in isolated cardiomyocytes, but lacks long-term therapeutic effects in vivo in a mouse model of hypertrophic cardiomyopathy.
    Cardiovasc Res. 2016; 109: 90-102

    Velasco A, Solow E, Price A, Wang Z, Arbique D, Arbique G, Adams-Huet B, Schwedhelm E, Lindner JR, Vongpatanasin W.
    Differential effects of nebivolol vs. metoprolol on microvascular function in hypertensive humans.
    Am J Physiol Heart Circ Physiol. 2016; 311: H118-24

    Atzler D, Appelbaum S, Cordts K, Ojeda FM, Wild PS,Münzel T, Blankenberg S, Böger RH, Blettner M, Beutel ME, Pfeiffer N, Zeller T, Lackner KJ, Schwedhelm E.
    Reference intervals of plasma homoarginine from the German Gutenberg Health Study.
    Clin Chem Lab Med. 2016; 54: 1231-7

    Mels CM, Huisman HW, Smith W, Schutte R, Schwedhelm E, Atzler D, Böger RH, Ware LJ, Schutte AE. The relationship of nitric oxide synthesis capacity, oxidative stress, and albumin-to-creatinine ratio in black and white men: the SABPA study.
    Age (Dordr) 2016; 38: 9

    Atzler D, Baum C, Ojeda F, Keller T, Cordts K, Schnabel RB, Choe CU, Lackner KJ, Münzel T, Böger RH, Blankenberg S, Schwedhelm E, Zeller T.
    Low Homoarginine Levels in the Prognosis of Patients With Acute Chest Pain.
    J Am Heart Assoc. 2016; 5: e002565

    Atzler D, Cracowski JL, Cordts K, Böger RH, Humbert M, Schwedhelm E.
    Homoarginine predicts mortality in treatment-naive patients with pulmonary arterial hypertension.
    Int J Cardiol. 2016; 217: 12-5

    Schnabel RB, Maas R, Wang N, Yin X, Larson MG, Levy D, Ellinor PT, Lubitz SA, McManus DD, Magnani JW, Atzler D, Böger RH, Schwedhelm E, Vasan RS, Benjamin EJ.
    Asymmetric dimethylarginine, related arginine derivatives, and incident atrial fibrillation.
    Am Heart J. 2016; 176: 100-6

    Lüneburg N, Siques P, Brito J, Arriaza K, Pena E, Klose H, Leon-Velarde F, Böger RH.
    Long-Term Chronic Intermittent Hypobaric Hypoxia in Rats Causes an Imbalance in the Asymmetric Dimethylarginine/Nitric Oxide Pathway and ROS Activity: A Possible Synergistic Mechanism for Altitude Pulmonary Hypertension?
    Pulm Med. 2016; 2016: 6578578

    Quintana-Villamandos B, González MC, Delgado-Martos MJ, Condezo-Hoyos L, Böger RH, Lüneburg N, Pazó-Sayós L, Gutiérrez-Arzapalo PY, Delgado-Baeza E.
    Short-term esmolol attenuates remodeling of the thoracic aorta in hypertensive rats by decreasing concentrations of ADMA down-regulated by oxidative stress.
    Eur J Pharmacol. 2016; 791:502-509

    Quintana-Villamandos B, Arnalich-Montiel A, Arribas S, Lüneburg N, Böger RH, Delgado-Martos MJ, Fernández-Criado C,Delgado-Baeza E, González MC.
    Early regression of coronary artery remodeling with esmolol and DDAH/ADMA pathway in hypertensive rats.
    Hypertens Res. 2016; 39: 692-700

    Harbaum L, Renk E, Yousef S, Glatzel A, Lüneburg N, Hennigs JK, Oqueka T, Baumann HJ, Atanackovic D, Grünig E, Böger RH, Bokemeyer C, Klose H.
    Acute effects of exercise on the inflammatory state in patients with idiopathic pulmonary arterial hypertension.

    BMC Pulm Med. 2016; 11: 145

    Zhang W, Jernerén f, Lehne BC, Chen MH, Luben RN, Johnston C, Elshorbagy A, Eppinga RN, Scott WR, Adeyeye E, Scott J, Böger RH, Khaw KT, van der Harst P, Wareham NJ, Vasan RS, Chambers JC, Refsum H, Kooner JS.
    Genome-wide association reveals that common genetic variation in the kallikrein-kinin system is assosiated with serum L-arginine levels.
    Thromb. Haemost. 2016; 116: 1041-1049

    Atzler D, Schönhoff M, Cordts K, Ortland I, Hoppe J, Hummel FC, Gerloff C, Jaehde U, Jagodzinski A, Böger RH, Choe CU, Schwedhelm E.
    Oral supplementation with L-homoarginine in young volunteers.
    Br J Clin Pharmacol. 2016; 82: 1477-1485

    Soltau I, Mudersbach E, Geissen M, Schwedhlem E, Einkler MS, Geffken M, Peine S, Schoen G, Debus ES, Larena-Avellaneda A, Daum G.
    Serum-Sphingosine-1-Phosphate Concentrations Are Inversely Associated with Atherosclerotic Diseases in Humans.
    PLoS One. 2016; 11: e0168302

    Klatt N, Scherschel K, Schad C, Lau D, Reitmeier A, Kuklik P, Meullerleile K, Yamamura J, Zeller T, Steven D, Baldus S, Schäffer B, Jungen C, Eickholt C, Wassilew Km Schwedhelm E, Willems S, Meyer C.
    Development of nonfibrotic left ventricular hypertrophy in an ANG II-induced chronic ovine hypertension model.
    Physiol Rep. 2016; 4: e12897

    Oetjen E.
    Regulation of Beta-Cell Function and Maas by the Dual Leucine Zipper Kinase.
    Arch Pharm (Weinheim). 2016; 349:410-3

  • Menghini R, Casagrande V, Cardellini M, Ballanti M, Davato F, Cardolini I, Stoehr R, Fabrizi M, Morelli M, Anemona L, Bernges I, Schwedhelm E, Ippoliti A, Mauriello A, Böger RH, Federici M.
    FoxO1 regulates asymmetric dimethylarginine via downregulation of dimethylaminohydrolase 1 in human endothelial cells and subjects with atherosclerosis.
    Atherosclerosis 2015; 242: 230-5

    Cordts K, Atzler D, Qaderi V, Sydow K, Böger RH, Choe CU, Schwedhelm E.
    Measurement of homoarginine in human and mouse plasma by LC-MS/MS and ELISA: a comparison and a biological application.
    Amino Acids 2015; 47: 2015-22

    Bahls M, Friedrich N, Atzler D, Felix SB, Nauck MA, Böger RH, Völzke H, Schwedhelm E, Dörr M.
    L-Arginine and SDMA Serum Concentrations Are Associated with Subclinical Atherosclerosis in the Study of Health in Pomerania (SHIP).
    PLoS One. 2015; 10:e0131293

    Stockebrand M, Hornig S, Neu A, Atzler D, Cordts K, Böger RH, Isbrandt D, Schwedhelm E, Choe CU. Homoarginine supplementation improves blood glucose in diet-induced obese mice.
    Amino Acids 2015; 47:1921-9

    Winkler MS, Nierhaus A, Holzmann M, Mudersbach E, Bauer A, Robbe L, Zahrte C, Geffken M, Peine S, Schwedhelm E, Daum G, Kluge S, Zoellner C.
    Decreased serum concentrations of sphingosine-1-phosphate in sepsis.
    Crit Care. 2015; 19: 372

    Kayacelebi AA, Langen J, Weigt-Usinger K, Chobanyan-Jürgens K, Mariotti F, Schneider JY, Rothmann S, Frölich JC, Atzler D, Choe CU, Schwedhelm E, Huneau JF, Lücke T, Tsikas D.
    Biosynthesis of homoarginine (hArg) and asymmetric dimethylarginine (ADMA) from acutely and chronically administered free L-arginine in humans.
    Amino Acids. 2015; 47: 1893-908

    Atzler D, Schwedhelm E, Choe CU.
    L-homoarginine and cardiovascular disease.
    Curr Opin Clin Nutr Metab Care. 2015; 18: 83-8

    Harbaum L, Oqueka T, Glatzel A, Hennings JK, Lüneburg N, Klose H.
    Does circulating IL-17 identify a subset of patients with idiopathic pulmonary arterial hypertension.
    Chest. 2015; 148: e131-2

    Wellbrock J, Harbaum L, Stamm H, Hennigs JK, Schulz B, Klose H, Bokemeyer C, Fiedler W, Lüneburg N. Intrinsic BMP Antagonist Gremlin-1 as a Novel Circulating Marker in Pulmonary Arterial Hypertension.
    Lung. 2015; 193: 567-70

    Winkler MS, Nierhaus A, Holzmann M, Mudersbach E, Bauer A, Robbe L, Zahrte C, Geffken M, Peine S, Schwedhelm E, Daum G, Kluge S, Zoellner C.
    Decreased serum concentrations of sphingosine-1-phosphate in sepsis.
    Crit Care. 2015; 19: 372

    Kayacelebi AA, Langen J, Weigt-Usinger K, Chobanyan-Jürgens K, Mariotti F, Schneider JY, Rothmann S, Frölich JC, Atzler D, Choe CU, Schwedhelm E, Huneau JF, Lücke T, Tsikas D.
    Biosynthesis of homoarginine (hArg) and asymmetric dimethylarginine (ADMA) from acutely and chronically administered free L-arginine in humans.
    Amino Acids. 2015; 47: 1893-908

    Atzler D, Schwedhelm E, Choe CU.
    L-homoarginine and cardiovascular disease.
    Curr Opin Clin Nutr Metab Care. 2015; 18: 83-8

    Nierhaus A, Winkler MS, Holzmann M, Mudersbach E, Bauer A, Robbe L, Zahrte C, Schwedhelm E, Daum G, Kluge S, Zoellner C.
    Sphingosine-1-phosphate is a novel biomarker in sepsis severity.
    Intensive Care Med Exp. 2015; 3 (Suppl. 1): A789

  • Lüneburg N, Lieb W, Zeller T, Chen MH, Maas R, Carter AM, Xanthakis V, Glazer NL, Schwedhelm E, Seshadri S, Ikram MA, Longstreth WT Jr,Fornage M, König IR, Loley C, Ojeda FM, Schillert A, Wang TJ, Sticht H, Kittel A, König J, Benjamin EJ, Sullivan LM, Bernges I, Anderssohn M, Ziegler A, Gieger C, Illig T, Meisinger C, Wichmann HE, Wild PS, Schunkert H, Psaty BM, Wiggins KL, Heckbert SR, Smith N, Lackner K, Lunetta KL, Blankenberg S, Erdmann J, Münzel T, Grant PJ, Vasan RS, Böger RH.
    Genome-Wide Association Study of L-Arginine and Dimethylarginines Reveals Novel Metabolic Pathway for Symmetric Dimethylarginine.
    Circ Cardiovasc Genet. 2014; 7: 864-72

    Atzler D, Gore MO, Ayers CR, Choe CU, Böger RH, de Lemos JA, McGuire DK, Schwedhelm E. Homoarginine and cardiovascular outcome in the population-based dallas heart study.
    Arterioscler Thromb Vasc Biol. 2014; 34: 2501-7

    Atzler D, Schwedhelm E, Nauck M, Ittermann T, Böger RH, Friedrich N.
    Serum reference intervals of homoarginine, ADMA, and SDMA in the Study of Health in Pomerania.
    Clin Chem Lab Med. 2014; 52: 1835-1842

    Schwedhelm E, Wallaschofski H, Atzler D, Dörr M, Nauck M, Völker U, Kroemer HK, Völzke H, Böger RH, Friedrich N.
    Incidence of all-cause and cardiovascular mortality predicted by symmetric dimethylarginine in the population-based study of health in pomerania.
    PLoS One. 2014; 9: e96875

    Anderssohn M, McLachlan S, Lüneburg N, Robertson C, Schwedhelm E, Williamson RM, Strachan MW, Ajjan R, Grant PJ, Böger RH, Price JF.
    Genetic and environmental determinants of dimethylarginines and association with cardiovascular disease in patients with type 2 diabetes.
    Diabetes Care. 2014; 37: 846-54

    Böger RH.
    The pharmacodynamics of L-arginine.
    Altern Ther Health Med. 2014; 20: 48-54

    Stahnke M-J, Dickel C, Schröder S, Kaiser D, Blume R, Stein R, Pouponnot C, Oetjen E.
    Inhibition of human insulin gene transcription and MafA transcriptional activity by the dual leucine zipper kinase.
    Cell Signal 2014; 26: 1792-1799

    Kaiser D, Oetjen E.
    Something old, something new and something very old – drugs for treating type 2 diabetes.
    Brit J Pharmacol. 2014; 171: 2940-2950

    Bauer J, Ripperger A, Frantz S, Ergün S, Schwedhelm E, Benndorf RA.
    Pathophysiology of isoprostanes in the cardiovascular system: implications of isoprostane-mediated thromboxane A2 receptor activation.
    Br J Pharmacol. 2014; 171: 3115-31

    Sinning C, Kieback A, Wild PS, Schnabel RB, Ojeda F, Appelbaum S, Zeller T, Lubos E, Schwedhelm E, Lackner KJ, Debus ES, Munzel T, Blankenberg S, Espinola-Klein C.
    Association of multiple biomarkers and classical risk factors with early carotid atherosclerosis: results from the Gutenberg Health Study.
    Clin Res Cardiol. 2014; 103: 477-85

    Atzler D, Schwedhelm E, Zeller T.
    Integrated genomics and metabolomics in nephrology.
    Nephrol Dial Transplant. 2014; 29: 1467-74

    Hennigs JK, Baumann HJ, Lüneburg N, Quast G, Harbaum L, Heyckendorf J, Sydow K, Schulte-Hubbert B, Halank M, Klose H.
    Fibrinogen plasma concentration is an independent marker of haemodynamic impairment in chronic thromboembolic pulmonary hypertension.
    Sci Rep. 2014; 4: 4808

    Halank M, Speich R, Petkova D, Saxer S, Müller-Mottet S, Hasler E, Kolditz M, Wilkens H, Ehlken N, Lichtblau M, Egenlauf B, Kähler C, Lüneburg N, Mertens D, Schulz U, Barner A, Grünig E, Puhan M,Ulrich S.
    Quality of life in pulmonal arterial hypertension and in chronic thromboembolic pulmonary hypertension.
    Dtsch Med. Wochenschr. 2014; 139 (Suppl. 4): S126-35

    Harbaum L, Hennigs JK, Baumann HJ, Lüneburg N, Griesch E, Bokemeyer C, Grünig E, Klose H.
    N-terminal pro-brain natriuretic peptide is a useful prognostic marker in patients with pre-capillary pulmonary hypertension and renal insufficiency.
    PLoS One. 2014; 9: e94263

    Lüneburg N, Harbaum L, Hennigs JK.
    The endothelial ADMA / NO pathway in hypoxia-related chronic respiratory diseases.
    Biomed Res Int. 2014; 2014: 501612

    Bauer J, Ripperger A, Frantz S, Ergün S, Schwedhelm E, Benndorf RA.
    Pathophysiology of isoprostanes in the cardiovascular system: implications of isoprostane-mediated thromboxane A2 receptor activation.
    Br J Pharmacol. 2014; 171: 3115-31

    Sinning C, Kieback A, Wild PS, Schnabel RB, Ojeda F, Appelbaum S, Zeller T, Lubos E, Schwedhelm E, Lackner KJ, Debus ES, Munzel T, Blankenberg S, Espinola-Klein C.
    Association of multiple biomarkers and classical risk factors with early carotid atherosclerosis: results from the Gutenberg Health Study.
    Clin Res Cardiol. 2014; 103: 477-85

    Atzler D, Schwedhlem E, Zeller T.
    Integrated genomics an metabolomics in nephrology.
    Nephrol Dial Transplant. 2014; 29: 1467-74

  • Donzelli S, Fischer G, King BS, Niemann C, Dumond JF, Heeren J, Wieboldt H, Baldus S, Gerloff C, Eschenhagen T, Carrier L, Boger RH, Espey MG.
    Pharmacological characterization of 1-nitrosocyclohexyl acetate, a long acting nitroxyl donor that shows vasorelaxant and anti-aggregator effect.
    J Pharmacol Exp Ther. 2013; 344: 339-47

    Ghebremariam YT, Yamada K, Lee JC, Johnson CL, Atzler D, Anderssohn M, Agrawal R, Higgins JP, Patterson AJ, Böger RH, Cooke JP. FXR
    Agonist INT-747 Upregulates DDAH Expression and Enhances Insulin Sensitivity in High-Salt Fed Dahl Rats.
    PLoS One. 2013; 8: e60653

    Glyn MC, Van Rooyen JM, Schutte R, Huisman HW, Böger RH, Schwedhelm E, Lüneburg N, Mels CM, Schutte AE.
    A comparison of the association between glomerular filtration and L-arginine status in HIV-infected and uninfected African men: the SAfrEIC study.
    J Hum Hypertens. 2013; 27: 557-63

    Gore MO, Lüneburg N, Schwedhelm E, Ayers CR, Anderssohn M, Khera A, Atzler D, de Lemos JA, Grant PJ, McGuire DK, Böger RH.
    Symmetrical dimethylarginine predicts mortality in the general population: observations from the Dallas heart study.
    Arterioscler Thromb Vasc Biol. 2013; 33: 2682-8

    Choe CU, Atzler D, Wild PS, Carter AM, Böger RH, Ojeda F, Simova O, Stockebrand M, Lackner K, Nabuurs C, Marescau B, Streichert T, Müller C, Lüneburg N,De Deyn PP, Benndorf RA, Baldus S, Gerloff C, Blankenberg S, Heerschap A, Grant PJ, Magnus T, Zeller T, Isbrandt D, Schwedhelm E.
    Homoarginine levels are regulated by L-arginine:glycine amidinotransferase and affect stroke outcome: results from human and murine studies.
    Circulation. 2013; 128: 1451-61

    Atzler D, Rosenberg M, Anderssohn M, Choe CU, Lutz M, Zugck C, Böger RH, Frey N, Schwedhelm E. Homoarginine--an independent marker of mortality in heart failure.
    Int J Cardiol. 2013; 168: 4907-9

    Betz B, Möller-Ehrlich K, Kress T, Kniepert J, Schwedhelm E, Böger RH, Wanner C, Sauvant C, Schneider R.
    Increased symmetrical dimethylarginine in ischemic acute kidney injury as a causative factor of renal L-arginine deficiency.
    Transl Res. 2013; 162: 67-76

    Galano JM, Mas E, Barden A, Mori TA, Signorini C, De Felice C, Barrett A, Opere C, Pinot E, Schwedhelm E, Benndorf R, Roy J, Le Guennec JY, Oger C, Durand T.
    Isoprostanes and neuroprostanes: total synthesis, biological activity and biomarkers of oxidative stress in humans.
    Prostaglandins Other Lipid Mediat. 2013; 107: 95-102

    Lange S, Fraune C, Alenina N, Bader M, Danser AH, Frenay AR, van Goor H, Stahl R, Nguyen G,Schwedhelm E, Wenzel UO.
    Aliskiren accumulation in the kidney: no major role for binding to renin or prorenin.
    J Hypertens. 2013; 31: 713-9

    Galano JM, Mas E, Barden A, Mori TA, Signorini C, De Felice C, Barrett A, Opere C, Pinot E, Schwedhelm E, Benndorf R, Roy J, Le Guennec JY, Oger C, Durand T.
    Isoprostanes and neuroprostanes: total synthesis, biological activity and biomarkers of oxidative stress in humans.
    Prostaglandins Other Lipid Mediat. 2013; 107: 95-102

  • Sobottka I, Wegscheider K, Balzer L, Böger RH, Hallier O, Giersdorf I, Streichert T, Haddad M, Platzer U, Cachovan G.
    Microbiological analysis of a prospective, randomized, double-blind trial comparing moxifloxacin and clindamycin in the treatment of odontogenic infiltrates and abscesses.
    Antimicrob Agents Chemother. 2012; 56: 2565-9

    Glyn MC, Anderssohn M, Lüneburg N, Van Rooyen JM, Schutte R, Huisman HW, Fourie CMT, Smith W, Malan L, Malan NT, Mels CMC, Böger RH, Schutte AE.
    Ethnic specific differences in L-arginine status in South African men.
    J. Hum. Hypertens. 2012; 26: 737-43

    Anderssohn M, Maass LM, Diemert A, Lüneburg N, Atzler D, Hecher K, Böger RH.
    Severely decreased activity of placental dimethylarginine dimethylaminohydrolase in pre-eclampsia.
    Eur J Obstet Gynecol Reprod Biol. 2012; 161: 152-6

    Lüneburg N, von Holten RA, Töpper RF, Schwedhelm E, Maas R, Böger RH.
    Symmetric dimethylarginine is a marker of detrimental outcome in the acute phase after ischaemic stroke: role of renal function.
    Clin Sci (Lond). 2012;122: 105-11

    Arlt S, Schwedhelm E, Kölsch H, Jahn H, Linnebank M, Smulders Y, Jessen F, Böger RH, Popp J. Dimethylarginines, homocysteine metabolism, and cerebrospinal fluid markers for Alzheimer's disease.
    J Alzheimers Dis. 2012; 31: 751-8

    Sydow K, Schmitz C, von Leitner EC, von Leitner R, Klinke A, Atzler D, Krebs C, Wieboldt H, Ehmke H, Schwedhelm E, Meinertz T, Blankenberg S, Böger RH, Magnus T, Baldus S, Wenzel U.
    Dimethylarginine dimethylaminohydrolase1 is an organ-specific mediator of end organ damage in a murine model of hypertension.
    PLoS One. 2012; 7: e48150

    Biermann D, Heilmann A, Didié M, Schlossarek S, Wahab A, Grimm M, Römer M, Reichenspurner H, Sultan KR, Steenpass A, Ergün S, Donzelli S, Carrier L, Ehmke H, Zimmermann WH, Hein L, Böger RH, Benndorf RA.
    Impact of AT2 receptor deficiency on postnatal cardiovascular development.
    PLoS One. 2012; 7: e47916

    Anderssohn M, Rosenberg M, Schwedhelm E, Zugck C, Lutz M, Lüneburg N, Frey N, Böger RH.
    The L-Arginine-Asymmetric Dimethylarginine Ratio is an Independent Predictor of Mortality in Dilated Cardiomyopathy.
    J Card Fail. 2012; 18: 904-11

    Oetjen E.
    Orale Antidiabetika.
    Kardiologe 2012; 6: 467-473

    Fraune C, Lange S, Krebs C, Hölzel A, Baucke J, Divac N, Schwedhelm E, Streichert T, Velden J, Garrelds IM, Danser AH, Frenay AR, van Goor H, Jankowski V, Stahl R, Nguyen G, Wenzel UO.
    AT1 antagonism and renin inhibition in mice: pivotal role of targeting angiotensin II in chronic kidney disease.
    Am J Physiol Renal Physiol. 2012; 303: F1037-48

    Cracowski JL, Degano B, Chabot F, Labarère J, Schwedhelm E, Monneret D, Iuliano L, Schwebel C, Chaouat A, Reynaud-Gaubert M, Faure P, Maas R, Renversez JC, Cracowski C, Sitbon O, Yaïci A, Simonneau G, Humbert M.
    Independent association of urinary F2-isoprostanes with survival in pulmonary arterial hypertension.
    Chest. 2012; 142: 869-76

  • Cachovan G, Böger RH, Giersdorf I, Hallier O, Streichert T, Haddad M, Platzer U, Schön G, Wegscheider K, Sobottka I.
    Efficacy and safety of moxifloxacin versus clindamycin in the treatment of odontogenic abscesses and iInflammatory infiltrates: A phase II, double-blind, randomized trial.
    Antimicrobial Agents Chemother. 2011; 55: 1142-1147

    Hu X, Atzler D, Zhang P, Guo H, Lu Z, Fassett J, Schwedhelm E, Böger RH, Bache RJ, Chen Y.
    Global dimethylarginine dimethylaminohydrolase-1 (DDAH1) gene-deficient mice reveal that DDAH1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine.
    Arterioscler. Thromb. Vasc. Biol. 2011; 31: 1540-6

    Pfeuffer M, Fielitz K, Laue C, Winkler P, Rubin D, Helwig U, Giller K, Kammann J, Schwedhelm E, Böger RH, Bub A, Bell D, Schrezenmeir J.
    CLA does not impair endothelial function and decreases body weight as compared with safflower oil in overweight and obese male subjects.
    J. Am. Coll. Nutr. 2011; 30: 19-28

    Schwedhelm E, Xanthakis V, Maas R, Sullivan LM, Atzler D, Lüneburg N, Glazer NL, Riederer U, Vasan RS, Böger RH.
    Plasma symmetric dimethylarginine reference limits from the Framingham offspring cohort.
    Clin. Chem. Lab. Med. 2011; 49: 1907-10

    Atzler D, Mieth M, Maas R, Böger RH, Schwedhelm E.
    Stable isotope dilution assay for high-throughput LC-tandem MS determination of L-homoarginine in human plasma.
    J. Chromatogr. B 2011; 879: 2294-8

    Lüneburg N, Xanthakis V, Schwedhelm E, Sullivan LM, Maas R, Anderssohn M, Riederer U, Glazer NL, Vasan RS, Böger RH.
    Reference intervals for plasma L-arginine and the L-arginine/ADMA ratio in the Framingham Offspring Cohort.
    Am. J. Nutr. 2011; 141: 2186-90

    von Leitner EC, Klinke A, Atzler D, Slocum JL, Lund N, Kielstein JT, Maas R, Schmidt-Haupt R, Pekarova M, Hellwinkel O, D`Alecy LG, Lau D, Willems S, Kubala L. Ehmke H, Meinertz T, Blankenberg S, Schwedhelm E, Gadegbeku CA, Böger RH, Baldus S, Sydow K.
    A pathogenic cycle between the endogenous NO synthase inhibitor asymmetric dimethylarginine and the leukocyte-derived hemoprotein myeloperoxidase.
    Circulation 2011; 124: 2735-45

    Benten D, Schulze zur Wisch J, Sydow K, Koops A, Buggisch P, Böger RH, Gaydos CA, Won H, Franco V, Thomas DL, Lohse AW, Ray S, Balagopal A.
    The transhepatic endotoxin gradient is present despite liver cirrhosis and is attenuated after transjugular portosystemic shunt (TIPS).
    Journal 2011; 11: 107

    Heese O, Böger RH, Westphal M.
    A survey on clinical study participation and study infrastructure at non-university hospitals in Germany.
    Int. J. Clin. Pharmacol. Ther. 2011; 49: 531-5

    Böger RH, Endres HG, Schwedhelm E, Darius H, Atzler D, Lüneburg N, von Stritzky B, Maas R, Thiem U, Benndorf RA, Diehm C.
    Asymmetric dimethylarginine as an independent risk marker for mortality in ambulatory patients with peripheral arterial disease.
    J Intern Med. 2011; 269: 349-61

    Schwedhelm E, Böger RH.
    The bad and the beast: The role of asymmetric and symmetric dimethylarginines in renal disease.
    Nat. Rev. Nephrol. 2011; 7: 275-85

  • Schulze F, Carter AM, Schwedhelm E, Ajjan R, Maas R, von Holten RA, Atzler D, Grant PJ, Böger RH. Symmetric dimethylarginine predicts all-cause mortality following ischemic stroke.
    Atherosclerosis 2010; 208: 518-523

    Schutte AE, Schutte R, Huisman HW, Van Rooyen JM, Malan L, Malan NT, Reimann M, Schwedhelm E, Strimbeanu S, Anderssohn M, Böger RH.
    Dimethylarginines: their vascular and metabolic roles in Africans and Caucasians.
    Eur. J. Endocrinol. 2010; 162: 525-533

    Rudolph V, Andrié RP, Rudolph TK, Friedrichs K, Klinke A, Hirsch-Hoffmann B, Schwoerer A, Lau D, Fu XM, Klingel K, Sydow K, Didié M, Seniuk A, von Leitner EC, Szoecs K, Schrickel JW, Treede H, Wenzel U, Lewalter T, Nickenig G, Zimmermann WH, Meinertz T, Böger RH, Reichenspurner H, Freeman BA, Eschenhagen T, Ehmke H, Hazen SL, Willems S, Baldus S.
    Myeloperoxidase, a mediator of atrial fibrillation.
    Nat. Med. 2010; 16: 470-474

    Weiss J, Sauer A, Divac N, Herzog M, Schwedhelm E, Böger RH, Haefeli WE, Benndorf RA.
    Interaction of angiotensin receptor type 1 blockers with ATP-binding cassette transporters.
    Biopharm. Durg Dispos. 2010; 31: 150-161

    Walcher T, Walcher D, Hetzel J, Mielke C, Rau M, Rittig K, Balletshofer B, Schwedhelm E, Hombach V, Böger RH, Koenig W, Marx N.
    Rapid effect of single-dose rosiglitazone treatment on endothelial function in healthy men with normal glucose tolerance: data from a randomised, placebo-controlled, double-blind study.
    Diab. Vasc. Dis. Res. 2010; 7: 178-185

    Jacobi J, Maas R, Cardounel AJ, Arend M, Pope AJ, Cordasic N, Heusinger-Ribeiro J, Atzler D, Strobel J, Schwedhelm E, Böger RH, Hilgers KF.
    Dimethylarginine dimethylaminohydrolase overexpression ameliorates atherosclerosis in apolipoprotein E-deficient mice by lowering asymmetric dimethylarginine.
    Am. J. Pathol. 2010; 176: 2559-2570

    Schwedhelm E, Bierend A, Maas R, Trinks R, Kom GD, Tsikas D, Böger RH.
    Redox-generated isoprostanes are associated with platelet activity in aspirin-treated patients with stable coronary heart disease.
    J. Thromb. Haemost. 2010; 8: 2662-2670

    El-Armouche A, Wahab A, Wittköpper K, Schulze T, Böttcher F, King SB, DuMond JF, Gerloff C, Böger RH, Eschenhagen T, Carrier L, Donzelli S.
    The new HNO donor, 1-nitrosocyclohexyl acetate, increases contractile force in normal and b-adrenergically desensitized ventricular myocytes
    Biochem. Biophys. Res. Commun. 2010; 402: 340-344

    Böger RH, Diemert A, Schwedhelm E, Lüneburg N, Maas R, Hecher K.
    The role of nitric oxide synthase inhibition by asymmetric dimethylarginine (ADMA) in the pathophysiology of preeclampsia.
    Gyn. Obstet. Invest. 2010; 69: 1-13

    Anderssohn M, Schwedhelm E, Lüneburg N, Vasan RS, Böger RH.
    ADMA (asymmetric dimethylarginine) as a mediator of vascular dysfunction and a marker of cardiovascular disease and mortality – an intriguing interaction with diabetes mellitus.
    Diab. Vasc. Dis. Res. 2010; 7: 105-118

    Deppe S, Böger RH, Weiss J, Benndorf RA.
    Telmisartan: a review of its pharmacodynamic and pharmacokinetic properties.
    Expert Opin. Drug Metab. Toxicol. 2010; 6: 863-871