Publikationen des Instituts für Klinische Pharmakologie und Toxikologie

  • Cordts K, Grzybowski R, Lezius S, Lüneburg N, Atzler D, Neu A, Hornig S, Böger RH, Gerloff C, Magnus T, Thomalla G, Schwedhelm E, Grant PJ, Choe CU.
    Guanidino compound ratios are associated with stroke etiology, internal carotid artery stenosis and CHA2DS2-VASc score in three cross-sectional studies.
    J Neurol Sci. 2019; 397: 156-161

    Morhenn K, Quentin T, Wichmann H, Steinmetz M, Prondzynski M, Söhren KD, Christ T, Geertz B, Schröder S, Schöndube FA, Hasenfuss G, Schlossarek S, Zimmermann WH, Carrier L, Eschenhagen T, Cardinaux JR, Lutz S, Oetjen E.
    Mechanistic role of the CREB-regulated transcription 1 in cardiac hypertrophy.
    J Mol Cell Cardiol. 2019; 127: 31-43

    Siquès P, Brito J, Schwedhelm E, Pena E, León-Velarde F, De La Cruz JJ, Böger RH, Hannemann J.
    Asymmetric Dimethylarginine at Sea Level Is a Predictive Marker of Hypoxic Pulmonary Arterial Hypertension at High Altitude.
    Front. Physiol. 2019; 10: 651

    Schäfer C, Mayr B, Müller EE, Augner C, Hannemann J, Böger RH, Schönfelder M, Niebauer J.
    Exercise training prior to night shift work improves physical work capacity and arterial stiffness.
    Eur J Prev Cardiol. 2019 May 8:2047487319848196

    Hennings JK, Lüneburg N, Stage A, Schmitz M, Körbelin J, Harbaum L, Matuszcak C, Mienert J, Bokemeyer C, Böger RH, Kiefmann R, Klose H.
    The P2-receptor-mediated Ca2+ signalosome of the human pulmonary endothelium - implications for pulmonary arterial hypertension.
    Purinergic Signal. 2019 Aug 8. doi: 10.1007/s11302-019-09674-1. [Epub ahead of print]

    Hübner M, Tomasi R, Effinger D, Wu T, Klein G, Bender M, Kilger E, Juchem G, Schwedhelm E, Kreth S.
    Myeloid-Derived Suppressor Cell Mediate Immunosuppression After Cardiopulmonary Bypass.
    Crit Care Med. 2019; 47: e700-e709

    Bollenbach A, Cordts K, Hanff E, Atzler D, Choe CU, Schwedhelm E, Tsikas.
    Evidence by GC-MS that lysine is an arginase-catalyzed metabolite of homoarginine in vitro and in vivo in humans.
    Anal Biochem. 2019; 577: 59-66

  • Schönhoff M, Weinecke G, Hoppe J, Hornig S, Cordts K, Atzler D, Gerloff C, Böger R, Neu A, Schwedhelm E, Choe CU.
    Cognitive performance of 20 healthy humans supplemented with L-homoarginine for 4 weeks.
    J Clin Neurosci. 2018; 50: 237-241

    Jordan W, Dobrowolny H, Bahn S, Bernstein HG, Brigadski T, Frodl T, Isermann V, Lessmann V, Pilz J, Rodenbeck A, Schiltz K, Schwedhelm E, Tumani H, Wiltfang J, Guest PC, Steiner J.
    Oxidative stress in drug-naïve first episode patients with schizophrenia and major depression: effects of disease acuity and potential confounders.
    Eur Arch Psychiatry Clin Neurosci. 2018; 268: 129-143

    Brito J, Siques P, López R, Romero R, León-Velarde F, Lüneburg N, Hannemann J, Böger RH.
    Long-Term Intermittent Work at High Altitude: Right Heart Functional and Morphological Status and Associated Cardiometabolic Factors.
    Front Physiol. 2018; 9: 248

    Appel D. Seeberger M, Schwedhelm E, Czorlich P, Goetz AE, Böger RH, Hannemann J.
    Asymmetric and Symmetric Dimethylarginines are Markers of Delayed Cerebral Ischemia and Neurological Outcome in Patients with Subarachnoid Hemorrhage.
    Neurocrit Care. 2018; 29: 84-93

    Baldassarri F, Schwedhelm E, Atzler D, Böger RH, Cordts K, Haller B, Pressler A, Müller S, Suchy C, Wachter R, Düngen HD, Hasenfuss G, Pieske B, Halle M, Edelmann F, Duvinage A.
    Relationship between exercise intervention and NO pathway in patients with heart failure with preserved ejection fraction.
    Biomarkers. 2018: 12; 1-11

    Bahls M, Atzler D, Markus MRP, Friedrich N, Böger RH, Völzke H, Felix SB, Schwedhelm E, Dörr M.
    Low-Circulating Homoarginine is Associated with Dilatation and Decreased Function of the Left Ventricle in the General Population.
    Biomolecules. 2018; 8: E63

    Loso J, Lund N, Avanesov M, Muschol N, Lezius S, Cordts K, Schwedhelm E, Patten M.
    Serum Biomarkers of Endothelial Dysfunction in Fabry Associated Cardiomyopathy.
    Front Cardiovasc Med. 2018; 5: 108

    Marx S, Splittstöhser M, Kinnen F, Moritz E, Joseph C, Paul S, Paland H, Seifert C, Marx M, Böhm A, Schwedhelm E, Holzer K, Singer S, Ritter CA, Bien-Möller S, Schroeder HWS, Rauch BH.
    Platelet activation parameters and platelet-leucocyte-conjugate formation in glioblastoma multiforme patients.
    Oncotarget. 2018; 9: 25860-25876

    Weske S, Vaidya M, Reese A, von Wnuck Lipinski K, Keul P, Bayer JK, Fischer JW, Flögel U, Nelsen J, Epple M, Scatena M, Schwedhelm E, Dörr M, Völzke H, Moritz E, Hannemann A, Rauch BH, Gräler MH, Heusch G, Levkau B.
    Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone loss.
    Nat Med. 2018; 24: 667-678

  • Wirth J, Atzler D, di Giuseppe R, Cordts K, Menzel J, Böger RH, Boeing H, Eikert C, Schwedhelm E.
    Higher serum asymmetric dimethylarginine is related to higher risk of heart failure in the EPIC-Potsdam study.
    Amino Acids. 2017; 49: 173-182

    Moritz E, Wegner D, Groß S, Bahls M, Dörr M, Felix SB, Ittermann T, Oswald S, Nauck M, Friedrich N, Böger RH, Daum G, Schwedhelm E, Rauch BH.
    Data on subgroup specific baseline characteristics and serum sphingosine-1phosphate concentrations in the Study of Health in Pomerania.
    Data Brief. 2017; 12: 46-50

    Atzler D, McAndrew DJ, Cordts K, Schneider JE, Zervou S, Schwedhelm E, Neubauer S, Lygate CA. Dietary Supplementation with Homoarginine Preserves Cardiac Function in a Murine Model of Post-Myocardial Infarction Heart Failure.
    Circulation 2017; 135:400-402

    Schwafertz C, Schinner S, Kühn MC, Haase M, Asmus A, Mülders-Opgenoorth B, Ansurudeen I, Hornsby PJ, Morawietz H, Oetjen E, Schott M, Willenberg HS.
    Endothelial cell regulate β-catenin activity in adrenocortical cells via secretion of basic fibroblast growth factor.
    Mol Cell Endocrinol. 2017; 441: 108-115

    Lüneburg N, Siques P, Brito J, De La Cruz JJ, León-Verde F, Hannemann J, Ibanez C, Böger RH.
    Long-Term intermittent exposure to high altitude elevates asymmetric dimethylarginine in first exposed young adults.
    High Alt Med Biol. 2017; 18: 226-233

    Nilam M, Gribbon P, Reinshagen J, Cordts K, Schwedhelm E, Nau WM, Henning A.
    A Label-Free Continuous Fluorescence-Based Assay for Monitoring Ornithine Decarboxylase Activity with a Synthetic Putrescine Receptor.
    SLAS Discov. 2017:22; 906-914

    Xu X, Zhang P, Kwak D, Fassett J, Yue W, Atzler D, Hu X, Wang H, Lu Z, Guo H, Schwedhelm E, Böger RH, Chen P, Chen Y.
    Cardiomyocyte dimethylarginine dimethylaminohydrolase-1 (DDAH1) plays an important role in attenuating ventricular hypertrophy and dysfunction.
    Basic Res Cardiol. 2017; 112: 55

    Winkler MS, Kluge S, Holzmann M, Moritz E, Robbe L, Bauer A, Zahrte C, Priefler M, Schwedhelm E, Böger RH, Goetz AE, Nierhaus A, Zoellner C.
    Markers of nitric oxide are associated with sepsis severity: an observational study.
    Crit Care. 2017; 21: 189

    Kloth B, Pecha S, Moritz E, Schneeberger Y, Söhren KD, Schwedhelm E, Reichenspurner H, Eschenhagen T, Böger RH, Christ T, Stehr SN.
    AkrinorTM, a Cafedrine/ Theodrenaline Mixture (20:1), Increases Force of Contraction of Human Atrial Myocardium But Does Not Constrict Internal Mammary Artery In Vitro.
    Front Pharmacol. 2017; 8: 272

    Zewinger S, Kleber ME, Rohrer L, Lehmann M, Triem S, Jennings RT, Petrakis I, Dressel A, Lepper PM, Scharnagl H, Ritsch A, Thorand B, Heier M, Meisinger C, de Las Heras Gala T, Koenig W, Wagenpfeil S, Schwedhelm E, Böger RH, Laufs U, von Eckardstein A, Landmesser U, Lüscher TF, Fliser D, März W, Meinitzer A, Speer T.
    Symmetric dimethylarginine, high-density lipoproteins and cardiovascular disease.
    Eur Heart J. 2017; 38: 1597-1607

    Moritz E, Wegner D, Groß S, Bahls M, Dörr M, Felix SB, Ittermann T, Oswald S, Nauck M, Friedrich N, Böger RH, Daum G, Schwedhelm E, Rauch BH.
    Reference intervals for serum sphingosine-1-phosphate in the population-based Study of Health in Pomerania.
    Clin Chem Acta. 2017; 468:25-31

    Mels CMC, Schutte AE, Huisman HW, Smith W, Kruger R, van Rooyen JM, Schwedhelm E, Atzler D, Böger RH, Malan NT,
    Asymmetric dimethylarginine and symmetric dimethylarginine prospectively relates to carotid wall thickening in black men: the SABPA study.
    Amino Acids. 2017; 49: 1843-1853

    Winkler MS, Rissiek A, Priefler M, Schwedhelm E, Robbe L, Bauer A, Zahrte C, Zoellner C, Kluge S, Nierhaus A.
    Human leucocyte antigen (HLA-DR) gene expression is reduced in sepsis and correlates with impaired TNFα response: A diagnostic tool for immunosuppression?
    PLoS One 2017; 12: e0182427

    Rudolph TK, Fuchs A, Klinke A, Schlichting A, Frierichs K, Hellmich M, Mollenhauer M, Schwedhelm E, Baldus S, Rudolph V.
    Prasugrel as opposed to clopidogrel improves endothelial nitric oxide bioavailability and reduces platelet-leukocyte interaction in patients with unstable angina pectoris: A randomized controlled trial.
    Int J Cardiol. 2017; 248:7-13

    Börchers S, Babaei R, Klimpel C, Duque Escobar J, Schröder S, Blume R, Malik MNH, Oetjen E.
    TNFα-induced DLK activation contributes to apoptosis in the beta-cell line HIT.
    Naunyn Schmiedebergs Arch Pharmacol. 2017; 390: 813-825

    Harbaum L, Baaske KM, Simon M, Oqueka T, Sinning C, Glatzel A, Lüneburg N, Sydow K, Bokemeyer C, Klose H.
    Exploratory analysis of the neutrophil to lymphocyte ratio in patients with pulmonary arterial hypertension.
    BMC Pulm Med. 2017; 17: 72

    Maas R, Xanthakis V, Göen T, Müller J, Schwedhelm E, Böger RH, Vasan RS.
    Plasma Nitrate and Incidence of Cardiovascular Disease and All-Cause Mortality in the Community: The Framingham Offspring Study.
    J Am Heart Assoc. 2017; 6: e006224

    Börchers S, Babaei R, Klimpel C, Duque Escobar J, Schröder S, Blume R, Malik MNH, Oetjen E.
    TNFα-induced DLK activation contributes to apoptosis in the beta-cell line HIT.
    Naunyn Schmiedebergs Arch Pharmacol. 2017; 390: 813-825

  • Ramuschkat M, Appelbaum S, Atzler D, Zeller T, Bauer C, Ojeda FM, Sinning CR, Hoffmann B, Lackner KJ, Böger RH, Wild PS, Münzel T, Blankenberg S, Schwedhelm E, Schnabel RB, Gutenberg Health Study investigators.
    ADMA, subclinical changes and atrial fibrillation in the general population.
    Int J Cardiol. 2016; 203: 640-646

    Baum C, Johannsen SS, Zeller T, Atzler D, Ojeda FM, Wild PS, Sinning CR, Lackner KJ, Gori T, Schwedhelm E, Böger RH, Blankenberg S, Münzel T, Schnabel RB; Gutenberg Health Study investigators.
    ADMA and arginine derivatives in relation to non-invasive vascular function in ther general population.
    Atherosclerosis 2016; 244: 149-156

    Mels CM, Loots I, Schwedhelm E, Atzler D, Böger RH, Schutte AE.
    Nitric oxide synthesis capacity ambulatory blood pressure and end organ damage in a black and white population: the SABPA study.
    Amino Acids 2016; 48: 801-10

    Ittermann T, Bahls M, Atzler D, Friedrich N, Schwedhelm E, Böger RH, Felix RH, Völzke H, Dörr M. Derivatives Are Associated with the Hyperthyroid State in the General Population.
    Thyroid 2016; 26: 212-8

    Wallbach M, Duque Escobar J, Babaeikelishomi R, Stahnke MJ, Blume R, Schröder S, Kruegel J, Maedler K, Kluth O, Kehlenbach RH, Miosge N, Oetjen E.
    Distinct functions of the dual leucine zipper kinase depending on its subcellular localization.
    Cell Signal. 2016; 28: 272-83

    Oetjen E, Lemcke T.
    Dual leucine zipper kinase (MAP3K12) modulators: a patent review (2010-2015).
    Expert Opin Ther Pat. 2016; 26: 607-16

    Flenner F, Friedrich FW, Ungeheuer N, Christ T, Geertz B, Reischmann S, Wagner S, Stathopoulou K, Söhren KD, Weinberger F, Schwedhelm E, Cuello F, Maier LS, Eschenhagen T, Carrier L.
    Ranolazine antagonizes catecholamine-induced dysfunction in isolated cardiomyocytes, but lacks long-term therapeutic effects in vivo in a mouse model of hypertrophic cardiomyopathy.
    Cardiovasc Res. 2016; 109: 90-102

    Velasco A, Solow E, Price A, Wang Z, Arbique D, Arbique G, Adams-Huet B, Schwedhelm E, Lindner JR, Vongpatanasin W.
    Differential effects of nebivolol vs. metoprolol on microvascular function in hypertensive humans.
    Am J Physiol Heart Circ Physiol. 2016; 311: H118-24

    Atzler D, Appelbaum S, Cordts K, Ojeda FM, Wild PS,Münzel T, Blankenberg S, Böger RH, Blettner M, Beutel ME, Pfeiffer N, Zeller T, Lackner KJ, Schwedhelm E.
    Reference intervals of plasma homoarginine from the German Gutenberg Health Study.
    Clin Chem Lab Med. 2016; 54: 1231-7

    Mels CM, Huisman HW, Smith W, Schutte R, Schwedhelm E, Atzler D, Böger RH, Ware LJ, Schutte AE. The relationship of nitric oxide synthesis capacity, oxidative stress, and albumin-to-creatinine ratio in black and white men: the SABPA study.
    Age (Dordr) 2016; 38: 9

    Atzler D, Baum C, Ojeda F, Keller T, Cordts K, Schnabel RB, Choe CU, Lackner KJ, Münzel T, Böger RH, Blankenberg S, Schwedhelm E, Zeller T.
    Low Homoarginine Levels in the Prognosis of Patients With Acute Chest Pain.
    J Am Heart Assoc. 2016; 5: e002565

    Atzler D, Cracowski JL, Cordts K, Böger RH, Humbert M, Schwedhelm E.
    Homoarginine predicts mortality in treatment-naive patients with pulmonary arterial hypertension.
    Int J Cardiol. 2016; 217: 12-5

    Schnabel RB, Maas R, Wang N, Yin X, Larson MG, Levy D, Ellinor PT, Lubitz SA, McManus DD, Magnani JW, Atzler D, Böger RH, Schwedhelm E, Vasan RS, Benjamin EJ.
    Asymmetric dimethylarginine, related arginine derivatives, and incident atrial fibrillation.
    Am Heart J. 2016; 176: 100-6

    Lüneburg N, Siques P, Brito J, Arriaza K, Pena E, Klose H, Leon-Velarde F, Böger RH.
    Long-Term Chronic Intermittent Hypobaric Hypoxia in Rats Causes an Imbalance in the Asymmetric Dimethylarginine/Nitric Oxide Pathway and ROS Activity: A Possible Synergistic Mechanism for Altitude Pulmonary Hypertension?
    Pulm Med. 2016; 2016: 6578578

    Quintana-Villamandos B, González MC, Delgado-Martos MJ, Condezo-Hoyos L, Böger RH, Lüneburg N, Pazó-Sayós L, Gutiérrez-Arzapalo PY, Delgado-Baeza E.
    Short-term esmolol attenuates remodeling of the thoracic aorta in hypertensive rats by decreasing concentrations of ADMA down-regulated by oxidative stress.
    Eur J Pharmacol. 2016; 791:502-509

    Quintana-Villamandos B, Arnalich-Montiel A, Arribas S, Lüneburg N, Böger RH, Delgado-Martos MJ, Fernández-Criado C,Delgado-Baeza E, González MC.
    Early regression of coronary artery remodeling with esmolol and DDAH/ADMA pathway in hypertensive rats.
    Hypertens Res. 2016; 39: 692-700

    Harbaum L, Renk E, Yousef S, Glatzel A, Lüneburg N, Hennigs JK, Oqueka T, Baumann HJ, Atanackovic D, Grünig E, Böger RH, Bokemeyer C, Klose H.
    Acute effects of exercise on the inflammatory state in patients with idiopathic pulmonary arterial hypertension.

    BMC Pulm Med. 2016; 11: 145

    Zhang W, Jernerén f, Lehne BC, Chen MH, Luben RN, Johnston C, Elshorbagy A, Eppinga RN, Scott WR, Adeyeye E, Scott J, Böger RH, Khaw KT, van der Harst P, Wareham NJ, Vasan RS, Chambers JC, Refsum H, Kooner JS.
    Genome-wide association reveals that common genetic variation in the kallikrein-kinin system is assosiated with serum L-arginine levels.
    Thromb. Haemost. 2016; 116: 1041-1049

    Atzler D, Schönhoff M, Cordts K, Ortland I, Hoppe J, Hummel FC, Gerloff C, Jaehde U, Jagodzinski A, Böger RH, Choe CU, Schwedhelm E.
    Oral supplementation with L-homoarginine in young volunteers.
    Br J Clin Pharmacol. 2016; 82: 1477-1485

    Soltau I, Mudersbach E, Geissen M, Schwedhlem E, Einkler MS, Geffken M, Peine S, Schoen G, Debus ES, Larena-Avellaneda A, Daum G.
    Serum-Sphingosine-1-Phosphate Concentrations Are Inversely Associated with Atherosclerotic Diseases in Humans.
    PLoS One. 2016; 11: e0168302

    Klatt N, Scherschel K, Schad C, Lau D, Reitmeier A, Kuklik P, Meullerleile K, Yamamura J, Zeller T, Steven D, Baldus S, Schäffer B, Jungen C, Eickholt C, Wassilew Km Schwedhelm E, Willems S, Meyer C.
    Development of nonfibrotic left ventricular hypertrophy in an ANG II-induced chronic ovine hypertension model.
    Physiol Rep. 2016; 4: e12897

    Oetjen E.
    Regulation of Beta-Cell Function and Maas by the Dual Leucine Zipper Kinase.
    Arch Pharm (Weinheim). 2016; 349:410-3

  • Menghini R, Casagrande V, Cardellini M, Ballanti M, Davato F, Cardolini I, Stoehr R, Fabrizi M, Morelli M, Anemona L, Bernges I, Schwedhelm E, Ippoliti A, Mauriello A, Böger RH, Federici M.
    FoxO1 regulates asymmetric dimethylarginine via downregulation of dimethylaminohydrolase 1 in human endothelial cells and subjects with atherosclerosis.
    Atherosclerosis 2015; 242: 230-5

    Cordts K, Atzler D, Qaderi V, Sydow K, Böger RH, Choe CU, Schwedhelm E.
    Measurement of homoarginine in human and mouse plasma by LC-MS/MS and ELISA: a comparison and a biological application.
    Amino Acids 2015; 47: 2015-22

    Bahls M, Friedrich N, Atzler D, Felix SB, Nauck MA, Böger RH, Völzke H, Schwedhelm E, Dörr M.
    L-Arginine and SDMA Serum Concentrations Are Associated with Subclinical Atherosclerosis in the Study of Health in Pomerania (SHIP).
    PLoS One. 2015; 10:e0131293

    Stockebrand M, Hornig S, Neu A, Atzler D, Cordts K, Böger RH, Isbrandt D, Schwedhelm E, Choe CU. Homoarginine supplementation improves blood glucose in diet-induced obese mice.
    Amino Acids 2015; 47:1921-9

    Winkler MS, Nierhaus A, Holzmann M, Mudersbach E, Bauer A, Robbe L, Zahrte C, Geffken M, Peine S, Schwedhelm E, Daum G, Kluge S, Zoellner C.
    Decreased serum concentrations of sphingosine-1-phosphate in sepsis.
    Crit Care. 2015; 19: 372

    Kayacelebi AA, Langen J, Weigt-Usinger K, Chobanyan-Jürgens K, Mariotti F, Schneider JY, Rothmann S, Frölich JC, Atzler D, Choe CU, Schwedhelm E, Huneau JF, Lücke T, Tsikas D.
    Biosynthesis of homoarginine (hArg) and asymmetric dimethylarginine (ADMA) from acutely and chronically administered free L-arginine in humans.
    Amino Acids. 2015; 47: 1893-908

    Atzler D, Schwedhelm E, Choe CU.
    L-homoarginine and cardiovascular disease.
    Curr Opin Clin Nutr Metab Care. 2015; 18: 83-8

    Harbaum L, Oqueka T, Glatzel A, Hennings JK, Lüneburg N, Klose H.
    Does circulating IL-17 identify a subset of patients with idiopathic pulmonary arterial hypertension.
    Chest. 2015; 148: e131-2

    Wellbrock J, Harbaum L, Stamm H, Hennigs JK, Schulz B, Klose H, Bokemeyer C, Fiedler W, Lüneburg N. Intrinsic BMP Antagonist Gremlin-1 as a Novel Circulating Marker in Pulmonary Arterial Hypertension.
    Lung. 2015; 193: 567-70

    Winkler MS, Nierhaus A, Holzmann M, Mudersbach E, Bauer A, Robbe L, Zahrte C, Geffken M, Peine S, Schwedhelm E, Daum G, Kluge S, Zoellner C.
    Decreased serum concentrations of sphingosine-1-phosphate in sepsis.
    Crit Care. 2015; 19: 372

    Kayacelebi AA, Langen J, Weigt-Usinger K, Chobanyan-Jürgens K, Mariotti F, Schneider JY, Rothmann S, Frölich JC, Atzler D, Choe CU, Schwedhelm E, Huneau JF, Lücke T, Tsikas D.
    Biosynthesis of homoarginine (hArg) and asymmetric dimethylarginine (ADMA) from acutely and chronically administered free L-arginine in humans.
    Amino Acids. 2015; 47: 1893-908

    Atzler D, Schwedhelm E, Choe CU.
    L-homoarginine and cardiovascular disease.
    Curr Opin Clin Nutr Metab Care. 2015; 18: 83-8

    Nierhaus A, Winkler MS, Holzmann M, Mudersbach E, Bauer A, Robbe L, Zahrte C, Schwedhelm E, Daum G, Kluge S, Zoellner C.
    Sphingosine-1-phosphate is a novel biomarker in sepsis severity.
    Intensive Care Med Exp. 2015; 3 (Suppl. 1): A789