Publikationen der Sektion Pädiatrische Stammzelltransplantation und Immunologie
2024
Survival in primary hemophagocytic lymphohistiocytosis, 2016 to 2021: etoposide is better than its reputation
Böhm S, Wustrau K, Pachlopnik Schmid J, Prader S, Ahlman M, Yacobovich J, Beier R, Speckmann C, Behnisch W, Ifversen M, Jordan M, Marsh R, Naumann-Bartsch N, Mauz-Koerholz C, Honig M, Schulz A, Malinowska I, Hines M, Nichols K, Gil-Herrera J, Talano J, Crooks B, Formankova R, Jorch N, Bakhtiar S, Kühnle I, Streiter M, Nathrath M, Russo A, Duerken M, Lang P, Lindemans C, Henter J, Lehmberg K, Ehl S
BLOOD. 2024;143(10):872-881.
Finding a balance in reduced toxicity hematopoietic stem cell transplantation for thalassemia: role of infused CD3+ cell count and immunosuppression
Meissner B, Lang P, Bader P, Hoenig M, Müller I, Meisel R, Greil J, Sauer M, Metzler M, Corbacioglu S, Burkhardt B, Wölfl M, Strahm B, Kafa K, Basu O, Lode H, Gruhn B, Cario H, Ozga A, Zimmermann M, Jarisch A, Beier R
BONE MARROW TRANSPL. 2024;59(5):587-596.
Haematopoietic stem cell transplantation after reduced intensity conditioning in children and adolescents with chronic myeloid leukaemia: A prospective multicentre trial of the I-BFM Study Group
Pichler H, Sedlacek P, Meisel R, Beier R, Faraci M, Kalwak K, Ifversen M, Müller I, Stein J, Vettenranta K, Kropshofer G, Kolenova A, Karlhuber S, Glogova E, Poetschger U, Peters C, Suttorp M, Matthes-Leodolter S, Balduzzi A
BRIT J HAEMATOL. 2024;205(1):268-279.
Glycan Structures in Osteosarcoma as Targets for Lectin-Based Chimeric Antigen Receptor Immunotherapy
Prasse N, Wessolowski C, Müller I, Cornils K, Franke A
INT J MOL SCI. 2024;25(10):.
2023
CD19 CAR T cells are an effective therapy for posttransplant relapse in patients with B-lineage ALL: Real-World Data from Germany
Bader P, Rossig C, Hutter M, Ayuk F, Baldus C, Bücklein V, Bonig H, Cario G, Einsele H, Holtick U, Koenecke C, Bakhtiar S, Künkele A, Meisel R, Mueller F, Müller I, Penack O, Rettinger E, Sauer M, Schlegel P, Soerensen J, von Stackelberg A, Strahm B, Feuchtinger T, Hauer J, Jarisch A
BLOOD ADV. 2023;7(11):2436-2448.
Immunodeficiency with susceptibility to lymphoma with complex genotype affecting energy metabolism (FBP1, ACAD9) and vesicle trafficking (RAB27A)
Brauer N, Maruta Y, Lisci M, Strege K, Oschlies I, Nakamura H, Böhm S, Lehmberg K, Brandhoff L, Ehl S, Parvaneh N, Klapper W, Fukuda M, Griffiths G, Hennies H, Niehues T, Ammann S
FRONT IMMUNOL. 2023;14:1151166.
Multiple sclerosis, disease-modifying drugs and risk for adverse perinatal and pregnancy outcomes: Results from a population-based cohort study
Fink K, Gorczyca A, Alping P, Englund S, Farmand S, Langer-Gould A, Piehl F, McKay K, Frisell T, Razaz N
MULT SCLER J. 2023;29(6):731-740.
Glyco-binding domain chimeric antigen receptors as a new option for cancer immunotherapy
Franke A, Wessolowski C, Thaden V, Müller I, Cornils K
GENE THER. 2023;30(7-8):603-611.
Epigenetic Modification of Mesenchymal Stromal Cells Derived from Bone Marrow and Embryonal Tumors to Facilitate Immunotherapeutic Approaches in Pediatric Malignancies
Kruchen A, Johann P, Rekowski L, Müller I
CURR ISSUES MOL BIOL. 2023;45(3):2121-2135.
Activated phosphoinositide 3-kinase δ syndrome: Update from the ESID Registry and comparison with other autoimmune-lymphoproliferative inborn errors of immunity
Maccari M, Wolkewitz M, Schwab C, Lorenzini T, Leiding J, Aladjdi N, Abolhassani H, Abou-Chahla W, Aiuti A, Azarnoush S, Baris S, Barlogis V, Barzaghi F, Baumann U, Bloomfield M, Bohynikova N, Bodet D, Boutboul D, Bucciol G, Buckland M, Burns S, Cancrini C, Cathébras P, Cavazzana M, Cheminant M, Chinello M, Ciznar P, Coulter T, D'Aveni M, Ekwall O, Eric Z, Eren E, Fasth A, Frange P, Fournier B, Garcia-Prat M, Gardembas M, Geier C, Ghosh S, Goda V, Hammarström L, Hauck F, Heeg M, Heropolitanska-Pliszka E, Hilfanova A, Jolles S, Karakoc-Aydiner E, Kindle G, Kiykim A, Klemann C, Koletsi P, Koltan S, Kondratenko I, Körholz J, Krüger R, Jeziorski E, Levy R, Le Guenno G, Lefevre G, Lougaris V, Marzollo A, Mahlaoui N, Malphettes M, Meinhardt A, Merlin E, Meyts I, Milota T, Moreira F, Moshous D, Mukhina A, Neth O, Neubert J, Neven B, Nieters A, Nove-Josserand R, Oksenhendler E, Ozen A, Olbrich P, Perlat A, Pac M, Schmid J, Pacillo L, Parra-Martinez A, Paschenko O, Pellier I, Sefer A, Plebani A, Plantaz D, Prader S, Raffray L, Ritterbusch H, Riviere J, Rivalta B, Rusch S, Sakovich I, Savic S, Scheible R, Schleinitz N, Schuetz C, Schulz A, Sediva A, Semeraro M, Sharapova S, Shcherbina A, Slatter M, Sogkas G, Soler-Palacin P, Speckmann C, Stephan J, Suarez F, Tommasini A, Trück J, Uhlmann A, van Aerde K, van Montfrans J, von Bernuth H, Warnatz K, Williams T, Worth A, Ip W, Picard C, Catherinot E, Nademi Z, Grimbacher B, Forbes Satter L, Kracker S, Chandra A, Condliffe A, Ehl S
J ALLERGY CLIN IMMUN. 2023;152(4):984-996.e10.
Development of a centralised triage centre for children with cancer and blood disorders in response to the humanitarian crisis in Ukraine
Salek M, Mueller A, Alanbousi I, Cepowska Z, Dutkiewicz M, Earl J, Evseev D, Kizyma R, Kliuchkivska K, Kolodrubiec J, Matczak K, Nogovitsyna Y, Oszer A, Pogorelyy M, Raciborska A, Rasul S, Sokolowski I, Sopilnyak A, Vinitsky A, Wlodarski M, Wobst N, Yakimkova T, Rodriguez-Galindo C, Wise P, Mlynarski W, Agulnik A
LANCET ONCOL. 2023;24(12):1315-1318.
Th1 cytokines in pediatric acute lymphoblastic leukemia
Schober S, Rottenberger J, Hilz J, Schmid E, Ebinger M, Feuchtinger T, Handgretinger R, Lang P, Queudeville M
CANCER IMMUNOL IMMUN. 2023;72(11):3621-3634.
MAP kinase activating death domain deficiency is a novel cause of impaired lymphocyte cytotoxicity
Schütze K, Groß M, Cornils K, Wustrau K, Schneppenheim S, Lenhartz H, Korenke G, Janka G, Ledig S, Müller I, Ehl S, Lehmberg K
BLOOD ADV. 2023;7(8):1531-1535.
Prospective Newborn Screening for SCID in Germany: A First Analysis by the Pediatric Immunology Working Group (API)
Speckmann C, Nennstiel U, Hönig M, Albert M, Ghosh S, Schuetz C, Brockow I, Hörster F, Niehues T, Ehl S, Wahn V, Borte S, Lehmberg K, Baumann U, Beier R, Krüger R, Bakhtiar S, Kuehl J, Klemann C, Kontny U, Holzer U, Meinhardt A, Morbach H, Naumann-Bartsch N, Rothoeft T, Kreins A, Davies E, Schneider D, Bernuth H, Klingebiel T, Hoffmann G, Schulz A, Hauck F
J CLIN IMMUNOL. 2023;43(5):965-978.
2022
Global effort to evacuate Ukrainian children with cancer and blood disorders who have been affected by war
Agulnik A, Kizyma R, Salek M, Wlodarski M, Pogorelyy M, Oszer A, Yakimkova T, Nogovitsyna Y, Dutkiewicz M, Dalle J, Dirksen U, Eggert A, Fernández-Teijeiro A, Greiner J, Kraal K, Mueller A, Sramkova L, Zecca M, Wise P, Mlynarski W
LANCET HAEMATOL. 2022;9(9):e645-e647.
Reduced-Intensity/Reduced-Toxicity Conditioning Approaches Are Tolerated in XIAP Deficiency but Patients Fare Poorly with Acute GVHD
Arnold D, Nofal R, Wakefield C, Lehmberg K, Wustrau K, Albert M, Morris E, Heimall J, Bunin N, Kumar A, Jordan M, Cole T, Choo S, Brettig T, Speckmann C, Ehl S, Salamonowicz M, Wahlstrom J, Rao K, Booth C, Worth A, Marsh R
J CLIN IMMUNOL. 2022;42(1):36-45.
Hematopoietic Stem Cell Transplantation with Mesenchymal Stromal Cells in Children with Metachromatic Leukodystrophy
Cabanillas Stanchi K, Böhringer J, Strölin M, Groeschel S, Lenglinger K, Treuner C, Kehrer C, Laugwitz L, Bevot A, Kaiser N, Schumm M, Lang P, Handgretinger R, Krägeloh-Mann I, Müller I, Döring M
STEM CELLS DEV. 2022;31(7-8):163-175.
Incidence of subsequent malignancies after total body irradiation-based allogeneic HSCT in children with ALL - long-term follow-up from the prospective ALL-SCT 2003 trial
Eichinger A, Poetschger U, Glogova E, Bader P, Basu O, Beier R, Burkhardt B, Classen C, Claviez A, Corbacioglu S, Deubzer H, Greil J, Gruhn B, Güngör T, Kafa K, Kühl J, Lang P, Lange B, Meisel R, Müller I, Sauer M, Schlegel P, Schulz A, Stachel D, Strahm B, Wawer A, Peters C, Albert M
LEUKEMIA. 2022;36(11):2567-2576.
Maternal versus paternal living kidney transplant donation is associated with lower rejection in young pediatric recipients: A Collaborative Transplant Study report
Engels G, Döhler B, Tönshoff B, Oh J, Kruchen A, Müller I, Süsal C
PEDIATR TRANSPLANT. 2022;26(1):.
The Reconstitution Dynamics of Cultivated Hematopoietic Stem Cells and Progenitors Is Independent of Age
Gotzhein F, Aranyossy T, Thielecke L, Sonntag T, Thaden V, Fehse B, Müller I, Glauche I, Cornils K
INT J MOL SCI. 2022;23(6):.
Rubella vaccine-induced granulomas are a novel phenotype with incomplete penetrance of genetic defects in cytotoxicity
Groß M, Speckmann C, May A, Gajardo-Carrasco T, Wustrau K, Maier S, Panning M, Huzly D, Agaimy A, Bryceson Y, Choo S, Chow C, Dückers G, Fasth A, Fraitag S, Gräwe K, Haxelmans S, Holzinger D, Hudowenz O, Hübschen J, Khurana C, Kienle K, Klifa R, Korn K, Kutzner H, Lämmermann T, Ledig S, Lipsker D, Meeths M, Naumann-Bartsch N, Rascon J, Schänzer A, Seidl M, Tesi B, Vauloup-Fellous C, Vollmer-Kary B, Warnatz K, Wehr C, Neven B, Vargas P, Sepulveda F, Lehmberg K, Schmitt-Graeff A, Ehl S
J ALLERGY CLIN IMMUN. 2022;149(1):388-399.e4.
Reduced adhesion of aged intestinal stem cells contributes to an accelerated clonal drift
Hageb A, Thalheim T, Nattamai K, Möhrle B, Saçma M, Sakk V, Thielecke L, Kerstin C, Grandy C, Port F, Gottschalk K, Mallm J, Glauche I, Galle J, Mulaw M, Geiger H
LIFE SCI ALLIANCE. 2022;5(8):.
Consensus-Based Guidelines for the Recognition, Diagnosis, and Management of Hemophagocytic Lymphohistiocytosis in Critically Ill Children and Adults
Hines M, von Bahr Greenwood T, Beutel G, Beutel K, Hays J, Horne A, Janka G, Jordan M, van Laar J, Lachmann G, Lehmberg K, Machowicz R, Miettunen P, La Rosée P, Shakoory B, Zinter M, Henter J
CRIT CARE MED. 2022;50(5):860-872.
Immune Ablation and Stem Cell Rescue in Two Pediatric Patients with Progressive Severe Chronic Graft-Versus-Host Disease
Kloehn J, Kruchen A, Schütze K, Wustrau K, Schrum J, Müller I
INT J MOL SCI. 2022;23(23):.
NET Release of Long-Term Surviving Neutrophils
Kolman J, Pagerols Raluy L, Müller I, Nikolaev V, Trochimiuk M, Appl B, Wadehn H, Dücker C, Stoll F, Boettcher M, Reinshagen K, Trah J
FRONT IMMUNOL. 2022;13:815412.
Allogeneic hematopoietic stem cell transplantation for adult HLH: a retrospective study by the chronic malignancies and inborn errors working parties of EBMT
Machowicz R, Suarez F, Wiktor-Jedrzejczak W, Eikema D, de Wreede L, Blok H, Isaksson C, Einsele H, Poiré X, van Dorp S, Nikolousis E, Johansson J, Kobbe G, Zecca M, Arnold R, Gerbitz A, Finke J, Díez-Martín J, Bonifazi F, McQuaker G, Lenhoff S, Rohrlich P, Theobald M, Ljungman P, Collin M, Albert M, Ehninger G, Carlson K, Halaburda K, Lehmberg K, Schönland S, Yakoub-Agha I, Gennery A, Lankester A, Kröger N
BONE MARROW TRANSPL. 2022;57(5):817-823.
Influence of Fetomaternal Microchimerism on Maternal NK Cell Reactivity against the Child's Leukemic Blasts
Martin L, Kruchen A, Fehse B, Müller I
BIOMEDICINES. 2022;10(3):.
Essential medicines for childhood cancer in Europe: a pan-European, systematic analysis by SIOPE
Otth M, Brack E, Kearns P, Kozhaeva O, Ocokoljic M, Schoot R, Vassal G
LANCET ONCOL. 2022;23(12):1537-1546.
Comparison of single copy gene‑based duplex quantitative PCR and digital droplet PCR for monitoring of expansion of CD19‑directed CAR T cells in treated patients
Schubert M, Berger C, Kunz A, Schmitt A, Badbaran A, Neuber B, Zeschke S, Wang L, Riecken K, Hückelhoven-Krauss A, Müller I, Müller-Tidow C, Dreger P, Kröger N, Ayuk F, Schmitt M, Fehse B
INT J ONCOL. 2022;60(5):.
2021
Is hematopoietic stem cell transplantation a therapeutic option for mucolipidosis type II?
Ammer L, Pohl S, Breyer S, Aries C, Denecke J, Perez A, Petzoldt M, Schrum J, Müller I, Muschol N
MOL GENET METAB REP. 2021;26:.
Irradiation-free re-conditioning in children following graft failure of a T cell-depleted graft from a haploidentical parent
Aydin S, Kruchen A, Wustrau K, Doering M, Schrum J, Müller I
BONE MARROW TRANSPL. 2021;56(6):1452-1454.
Hematopoietic stem cell transplantation in children and adolescents with GATA2-related myelodysplastic syndrome
Bortnick R, Wlodarski M, de Haas V, De Moerloose B, Dworzak M, Hasle H, Masetti R, Starý J, Turkiewicz D, Ussowicz M, Kozyra E, Albert M, Bader P, Bordon V, Cario G, Beier R, Schulte J, Bresters D, Müller I, Pichler H, Sedlacek P, Sauer M, Zecca M, Göhring G, Yoshimi A, Noellke P, Erlacher M, Locatelli F, Niemeyer C, Strahm B
BONE MARROW TRANSPL. 2021;56(11):2732-2741.
Long-term follow-up after the application of mesenchymal stromal cells in children and adolescents with steroid-refractory graft-versus-host disease
Döring M, Cabanillas Stanchi K, Lenglinger K, Treuner C, Gieseke F, Erbacher A, Mezger M, Vaegler M, Schlegel P, Greil J, Bettoni da Cunha Riehm C, Faul C, Schumm M, Lang P, Handgretinger R, Müller I
STEM CELLS DEV. 2021;30(5):234-246.
Is neutralization of IFN-γ sufficient to control inflammation in HLH?
Ehl S, von Bahr Greenwood T, Bergsten E, Fischer A, Henter J, Hines M, Lehmberg K, Janka G, Moshous D, Nichols K
PEDIATR BLOOD CANCER. 2021;68(3):e28886.
Chronisch-rezidivierende Gonarthritis und Autoimmunneutropenie
Fröhlich A, Lehmberg K, Pagel J, Peldschus K, Schoof B, Schulze-Sturm U, Speth F
arthritis + rheuma. 2021;41(6):387-392.
Hematopoietic Cell Transplantation Cures Adenosine Deaminase 2 Deficiency: Report on 30 Patients
Hashem H, Bucciol G, Ozen S, Unal S, Bozkaya I, Akarsu N, Taskinen M, Koskenvuo M, Saarela J, Dimitrova D, Hickstein D, Hsu A, Holland S, Krance R, Sasa G, Kumar A, Müller I, Abreu de Sousa M, Delafontaine S, Moens L, Babor F, Barzaghi F, Cicalese M, Bredius R, van Montfrans J, Baretta V, Cesaro S, Stepensky P, Benedicte N, Moshous D, Le Guenno G, Boutboul D, Dalal J, Brooks J, Dokmeci E, Dara J, Lucas C, Hambleton S, Wilson K, Jolles S, Koc Y, Güngör T, Schnider C, Candotti F, Steinmann S, Schulz A, Chambers C, Hershfield M, Ombrello A, Kanakry J, Meyts I
J CLIN IMMUNOL. 2021;41(7):1633-1647.
HSCT is effective in patients with PSTPIP1-associated myeloid-related proteinemia inflammatory (PAMI) syndrome
Laberko A, Burlakov V, Maier S, Abinun M, Skinner R, Kozlova A, Suri D, Lehmberg K, Müller I, Balashov D, Novichkova G, Holzinger D, Gennery A, Shcherbina A
J ALLERGY CLIN IMMUN. 2021;148(1):250-255.e1.
Primary haemophagocytic lymphohistiocytosis (Chédiak-Higashi Syndrome) triggered by acute SARS-CoV-2 infection in a six-week-old infant
Lange M, Linden T, Müller H, Flasskuehler M, Koester H, Lehmberg K, Ledig S, Ehl S, Heep A, Beske F
BRIT J HAEMATOL. 2021;195(2):198-200.
Case Report: Hemophagocytic Lymphohistiocytosis and Non-Tuberculous Mycobacteriosis Caused by a Novel GATA2 Variant
Mika T, Vangala D, Eckhardt M, La Rosée P, Lange C, Lehmberg K, Wohlschläger C, Biskup S, Fuchs I, Mann J, Ehl S, Warnatz K, Schroers R
FRONT IMMUNOL. 2021;12:.
Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes
Sahoo S, Pastor V, Goodings C, Voss R, Kozyra E, Szvetnik A, Noellke P, Dworzak M, Starý J, Locatelli F, Masetti R, Schmugge M, De Moerloose B, Catala A, Kállay K, Turkiewicz D, Hasle H, Buechner J, Jahnukainen K, Ussowicz M, Polychronopoulou S, Smith O, Fabri O, Barzilai S, de Haas V, Baumann I, Schwarz-Furlan S, Niewisch M, Sauer M, Burkhardt B, Lang P, Bader P, Beier R, Müller I, Albert M, Meisel R, Schulz A, Cario G, Panda P, Wehrle J, Hirabayashi S, Derecka M, Durruthy-Durruthy R, Göhring G, Yoshimi-Noellke A, Ku M, Lebrecht D, Erlacher M, Flotho C, Strahm B, Niemeyer C, Wlodarski M
NAT MED. 2021;27(10):1806-1817.
Initial presenting manifestations in 16,486 patients with inborn errors of immunity include infections and noninfectious manifestations
Thalhammer J, Kindle G, Nieters A, Rusch S, Seppänen M, Fischer A, Grimbacher B, Edgar D, Buckland M, Mahlaoui N, Ehl S
J ALLERGY CLIN IMMUN. 2021;148(5):1332-1341.e5.
Simple Measurement of IgA Predicts Immunity and Mortality in Ataxia-Telangiectasia
Zielen S, Duecker R, Woelke S, Donath H, Bakhtiar S, Buecker A, Kreyenberg H, Huenecke S, Bader P, Mahlaoui N, Ehl S, El-Helou S, Pietrucha B, Plebani A, van der Flier M, van Aerde K, Kilic S, Reda S, Kostyuchenko L, McDermott E, Galal N, Pignata C, Pérez J, Laws H, Niehues T, Kutukculer N, Seidel M, Marques L, Ciznar P, Edgar J, Soler-Palacín P, von Bernuth H, Krueger R, Meyts I, Baumann U, Kanariou M, Grimbacher B, Hauck F, Graf D, Granado L, Prader S, Reisli I, Slatter M, Rodríguez-Gallego C, Arkwright P, Bethune C, Deripapa E, Sharapova S, Lehmberg K, Davies E, Schuetz C, Kindle G, Schubert R
J CLIN IMMUNOL. 2021;41(8):1878-1892.
2020
Functional flow cytometry of monocytes for routine diagnosis of innate primary immunodeficiencies
Ammann S, Fuchs S, Martin-Martin L, Castro C, Spielberger B, Klemann C, Elling R, Heeg M, Speckmann C, Hainmann I, Kaiser-Labusch P, Horneff G, Thalhammer J, Bredius R, Stadt U, Lehmberg K, Fuchs I, von Spee-Mayer C, Henneke P, Ehl S
J ALLERGY CLIN IMMUN. 2020;145(1):434-437.e4.
Accurate In-Vivo Quantification of CD19 CAR-T Cells after Treatment with Axicabtagene Ciloleucel (Axi-Cel) and Tisagenlecleucel (Tisa-Cel) Using Digital PCR
Badbaran A, Berger C, Riecken K, Kruchen A, Geffken M, Müller I, Kröger N, Ayuk F, Fehse B
CANCERS. 2020;12(7):.
Stem cell transplantation for children with hemophagocytic lymphohistiocytosis: results from the HLH-2004 study
Bergsten E, Horne A, Hed Myrberg I, Aricó M, Astigarraga I, Ishii E, Janka G, Ladisch S, Lehmberg K, McClain K, Minkov M, Nanduri V, Rosso D, Sieni E, Winiarski J, Henter J
BLOOD ADV. 2020;4(15):3754-3766.
Early clinical course after hematopoietic stem cell transplantation in children with juvenile metachromatic leukodystrophy
Beschle J, Döring M, Kehrer C, Raabe C, Bayha U, Strölin M, Böhringer J, Bevot A, Kaiser N, Bender B, Grimm A, Lang P, Müller I, Krägeloh-Mann I, Groeschel S
Molecular and cellular pediatrics. 2020;7(1):12.
Hemophagocytic lymphohistiocytosis in adults: collaborative analysis of 137 cases of a nationwide German registry
Birndt S, Schenk T, Heinevetter B, Brunkhorst F, Maschmeyer G, Rothmann F, Weber T, Müller M, Panse J, Penack O, Schroers R, Braess J, Frickhofen N, Ehl S, Janka G, Lehmberg K, Pletz M, Hochhaus A, Ernst T, La Rosée P
J CANCER RES CLIN. 2020;146(4):1065-1077.
Genome-wide analysis of acute leukemia and clonally related histiocytic sarcoma in a series of three pediatric patients
Bleeke M, Johann P, Gröbner S, Alten J, Cario G, Schäfer H, Klapper W, Khoury J, Pfister S, Müller I
PEDIATR BLOOD CANCER. 2020;67(2):e28074.
Neuroinflammatory Disease as an Isolated Manifestation of Hemophagocytic Lymphohistiocytosis
Blincoe A, Heeg M, Campbell P, Hines M, Khojah A, Klein-Gitelman M, Talano J, Speckmann C, Touzot F, Lankester A, Legger G, Rivière J, Garcia-Prat M, Alonso L, Putti M, Lehmberg K, Maier S, El Chazli Y, Elmaksoud M, Astigarraga I, Kurjane N, Bulina I, Kenina V, Bryceson Y, Rascon J, Lortie A, Goldstein G, Booth C, Worth A, Wassmer E, Schmitt E, Warren J, Bednarski J, Ali S, Chiang K, Krueger J, Henry M, Holland S, Marsh R, Ehl S, Haddad E
J CLIN IMMUNOL. 2020;40(6):901-916.
Longtime Outcome After Intraosseous Application of Autologous Mesenchymal Stromal Cells in Pediatric Patients and Young Adults with Avascular Necrosis After Steroid or Chemotherapy
Döring M, Kluba T, Cabanillas Stanchi K, Kahle P, Lenglinger K, Tsiflikas I, Treuner C, Vaegler M, Mezger M, Erbacher A, Schumm M, Lang P, Handgretinger R, Müller I
STEM CELLS DEV. 2020;29(13):811-822.
Targeted busulfan-based reduced-intensity conditioning and HLA-matched HSCT cure hemophagocytic lymphohistiocytosis
Felber M, Steward C, Kentouche K, Fasth A, Wynn R, Zeilhofer U, Haunerdinger V, Volkmer B, Prader S, Gruhn B, Ehl S, Lehmberg K, Müller D, Gennery A, Albert M, Hauck F, Rao K, Veys P, Hassan M, Lankester A, Schmid J, Hauri-Hohl M, Güngör T
BLOOD ADV. 2020;4(9):1998-2010.
Tuberculosis-Associated HLH in an 8-Month-Old Infant: A Case Report and Review
Hauch H, Skrzypek S, Woessmann W, Lehmberg K, Ehl S, Speckmann C, Schneck E, Koerholz D, Jux C, Neuhäuser C
FRONT PEDIATR. 2020;8:.
Distinct molecular response patterns of activating STAT3 mutations associate with penetrance of lymphoproliferation and autoimmunity
Jägle S, Heeg M, Grün S, Rensing-Ehl A, Maccari M, Klemann C, Jones N, Lehmberg K, Bettoni C, Warnatz K, Grimbacher B, Biebl A, Schauer U, Hague R, Neth O, Mauracher A, Pachlopnik Schmid J, Fabre A, Kostyuchenko L, Führer M, Lorenz M, Schwarz K, Rohr J, Ehl S
CLIN IMMUNOL. 2020;210:108316.
Treosulfan-fludarabine-thiotepa-based conditioning treatment before allogeneic hematopoietic stem cell transplantation for pediatric patients with hematological malignancies
Kalwak K, Mielcarek M, Patrick K, Styczynski J, Bader P, Corbacioglu S, Burkhardt B, Sykora K, Drabko K, Gozdzik J, Fagioli F, Greil J, Gruhn B, Beier R, Locatelli F, Müller I, Schlegel P, Sedlacek P, Stachel K, Hemmelmann C, Möller A, Baumgart J, Vora A
BONE MARROW TRANSPL. 2020;55(10):1996-2007.
Hematopoietic stem cell transplantation for children with acute myeloid leukemia-results of the AML SCT-BFM 2007 trial
Sauer M, Lang P, Albert M, Bader P, Creutzig U, Eyrich M, Greil J, Gruhn B, Holter W, Klingebiel T, Kremens B, von der Leyen H, Mauz-Körholz C, Meisel R, Mischke K, Müller I, Niemeyer C, Peters C, Pohler C, Reinhardt D, Burkhardt B, Schlegel P, Schulz A, Schrum J, Sedlacek P, Strahm B, Woessmann W, Handgretinger R, Zimmermann M, Borkhardt A
LEUKEMIA. 2020;34(2):613-624.
Incidence of SCID in Germany from 2014 to 2015 an ESPED* Survey on Behalf of the API*** Erhebungseinheit für Seltene Pädiatrische Erkrankungen in Deutschland (German Paediatric Surveillance Unit) ** Arbeitsgemeinschaft Pädiatrische Immunologie
Shai S, Perez-Becker R, Andres O, Bakhtiar S, Bauman U, von Bernuth H, Classen C, Dückers G, El-Helou S, Gangfuß A, Ghosh S, Grimbacher B, Hauck F, Hoenig M, Husain R, Kindle G, Kipfmueller F, Klemann C, Krüger R, Lainka E, Lehmberg K, Lohrmann F, Morbach H, Naumann-Bartsch N, Oommen P, Schulz A, Seidemann K, Speckmann C, Sykora K, von Kries R, Niehues T
J CLIN IMMUNOL. 2020;40(5):708-717.
Favorable outcomes of hematopoietic stem cell transplantation in children and adolescents with Diamond-Blackfan anemia
Strahm B, Loewecke F, Niemeyer C, Albert M, Ansari M, Bader P, Bertrand Y, Burkhardt B, Da Costa L, Ferster A, Fischer A, Güngör T, Gruhn B, Hainmann I, Kapp F, Lang P, Müller I, Schulz A, Szvetnik A, Wlodarski M, Noellke P, Leblanc T, Dalle J
BLOOD ADV. 2020;4(8):1760-1769.
Ulceration in Prolidase Deficiency: Successful Treatment with Anticoagulants
Süßmuth K, Metze D, Muresan A, Lehmberg K, Zur Stadt U, Speckmann C, Park J, Marquardt T, Oji V, Goerge T
ACTA DERM-VENEREOL. 2020;100(1):adv00002.
genBaRcode - a comprehensive R package for genetic barcode analysis
Thielecke L, Cornils K, Glauche I
BIOINFORMATICS. 2020;36(7):2189-2194.
Influence of anti-thymocyte globulin plasma levels on outcome parameters in stem cell transplanted children
Vogelsang V, Kruchen A, Wustrau K, Spohn M, Müller I
INT IMMUNOPHARMACOL. 2020;83:106371.
Cell Versus Cytokine - Directed Therapies for Hemophagocytic Lymphohistiocytosis (HLH) in Inborn Errors of Immunity
Wegehaupt O, Wustrau K, Lehmberg K, Ehl S
FRONT IMMUNOL. 2020;11:.
Risk factors for mixed chimerism in children with hemophagocytic lymphohistiocytosis after reduced toxicity conditioning
Wustrau K, Greil J, Sykora K, Albert M, Burkhardt B, Lang P, Meisel R, Wössmann W, Beier R, Schulz A, Bader P, Chada M, Kühl J, Schlegel P, Speckmann C, Gruhn B, Seidel M, Wawer A, Ozga A, Janka G, Ehl S, Müller I, Lehmberg K
PEDIATR BLOOD CANCER. 2020;67(9):e28523.
2019
Zinkmangel als Ursache eines „Dekubitus“ beim Frühgeborenen?
Asselborn J, Thayssen M, Lehmberg K, Apostolidou S, Singer D
Z GEBURTSH NEONATOL. 2019;223(6):369-372.
Presence of centromeric but absence of telomeric group B KIR haplotypes in stem cell donors improve leukaemia control after HSCT for childhood ALL
Babor F, Peters C, Manser A, Glogova E, Sauer M, Pötschger U, Ahlmann M, Cario G, Feuchtinger T, Gruhn B, Güngör T, Kremens B, Lang P, Mezger M, Müller I, Mytilineos J, Oevermann L, Pichler H, Scherenschlich N, Schuster F, Siepermann M, Stachel D, Strahm B, Wössmann W, Escherich G, Zimmermann M, Schrappe M, Borkhardt A, Eckert C, Bader P, Uhrberg M, Meisel R
BONE MARROW TRANSPL. 2019;54(11):1847-1858.
Clostridium difficile infection after pediatric solid organ transplantation: a practical single-center experience
Breuer C, Döring S, Rohde H, Rutkowski S, Müller I, Oh J
PEDIATR NEPHROL. 2019;34(7):1269-1275.
Comparison of procalcitonin and C-reactive protein as early diagnostic marker for the identification of transplant-related adverse events after allogeneic hematopoietic stem cell transplantation in pediatric patients
Cabanillas Stanchi K, Queudeville M, Malaval C, Feucht J, Schlegel P, Dobratz M, Seitz C, Müller I, Lang P, Handgretinger R, Döring M
J CANCER RES CLIN. 2019;145(11):2779-2791.
A multicenter study of patients with multisystem Langerhans cell histiocytosis who develop secondary hemophagocytic lymphohistiocytosis
Chellapandian D, Hines M, Zhang R, Jeng M, van den Bos C, Santa-María López V, Lehmberg K, Sieni E, Wang Y, Nakano T, Williams J, Fustino N, Astigarraga I, Dunkel I, Abla O, van Halteren A, Pei D, Cheng C, Weitzman S, Sung L, Nichols K
CANCER-AM CANCER SOC. 2019;125(6):963-971.
The German National Registry of Primary Immunodeficiencies (2012-2017)
El-Helou S, Biegner A, Bode S, Ehl S, Heeg M, Maccari M, Ritterbusch H, Speckmann C, Rusch S, Scheible R, Warnatz K, Atschekzei F, Beider R, Ernst D, Gerschmann S, Jablonka A, Mielke G, Schmidt R, Schürmann G, Sogkas G, Baumann U, Klemann C, Viemann D, von Bernuth H, Krüger R, Hanitsch L, Scheibenbogen C, Wittke K, Albert M, Eichinger A, Hauck F, Klein C, Rack-Hoch A, Sollinger F, Avila A, Borte M, Borte S, Fasshauer M, Hauenherm A, Kellner N, Müller A, Ülzen A, Bader P, Bakhtiar S, Lee J, Heß U, Schubert R, Wölke S, Zielen S, Ghosh S, Laws H, Neubert J, Oommen P, Hönig M, Schulz A, Steinmann S, Schwarz K, Dückers G, Lamers B, Langemeyer V, Niehues T, Shai S, Graf D, Müglich C, Schmalzing M, Schwaneck E, Tony H, Dirks J, Haase G, Liese J, Morbach H, Foell D, Hellige A, Wittkowski H, Masjosthusmann K, Geberzahn L, Hedrich C, Müller C, Rösen-Wolff A, Roesler J, Zimmermann A, Behrends U, Rieber N, Schauer U, Handgretinger R, Holzer U, Henes J, Kanz L, Boesecke C, Rockstroh J, Schwarze-Zander C, Wasmuth J, Dilloo D, Hülsmann B, Schönberger S, Schreiber S, Zeuner R, Ankermann T, von Bismarck P, Huppertz H, Kaiser-Labusch P, Greil J, Jakoby D, Kulozik A, Metzler M, Naumann-Bartsch N, Sobik B, Graf N, Heine S, Kobbe R, Lehmberg K, Müller I, Herrmann F, Horneff G, Klein A, Peitz J, Schmidt N, Bielack S, Groß-Wieltsch U, Classen C, Klasen J, Deutz P, Kamitz D, Lassay L, Tenbrock K, Wagner N, Bernbeck B, Brummel B, Lara-Villacanas E, Münstermann E, Schneider D, Tietsch N, Westkemper M, Weiß M, Kramm C, Kühnle I, Kullmann S, Girschick H, Specker C, Vinnemeier-Laubenthal E, Haenicke H, Schweigerer L, Müller T, Stiefel M, Belohradsky B, Soetedjo V, Kindle G, Grimbacher B
FRONT IMMUNOL. 2019;10:1272.
Pegvaliase: Immunological profile and recommendations for the clinical management of hypersensitivity reactions in patients with phenylketonuria treated with this enzyme substitution therapy
Hausmann O, Daha M, Longo N, Knol E, Müller I, Northrup H, Brockow K
MOL GENET METAB. 2019;128(1-2):84-91.
EZH2 Inhibition in Ewing Sarcoma Upregulates G Expression for Targeting with Gene-Modified T Cells
Kailayangiri S, Altvater B, Lesch S, Balbach S, Göttlich C, Kühnemundt J, Mikesch J, Schelhaas S, Jamitzky S, Meltzer J, Farwick N, Greune L, Fluegge M, Kerl K, Lode H, Siebert N, Müller I, Walles H, Hartmann W, Rossig C
MOL THER. 2019;27(5):933-946.
Haematopoietic Stem Cell Transplantation for Primary Haemophagocytic Lymphohistiocytosis
Lehmberg K, Moshous D, Booth C
FRONT PEDIATR. 2019;7:435.
Allogeneic hematopoietic stem cell transplantation in two brothers with DNA ligase IV deficiency -a case report and review of the literature
Schober S, Schilbach K, Doering M, Cabanillas Stanchi K, Holzer U, Kasteleiner P, Schittenhelm J, Schaefer J, Müller I, Lang P, Handgretinger R
BMC PEDIATR. 2019;19(1):346.
The Actin Binding Protein Plastin-3 Is Involved in the Pathogenesis of Acute Myeloid Leukemia
Velthaus A, Cornils K, Hennigs J, Grüb S, Stamm H, Wicklein D, Bokemeyer C, Heuser M, Windhorst S, Fiedler W, Wellbrock J
CANCERS. 2019;11(11):.
Risikofaktoren für einen gemischten Chimerismus nach Stammzelltransplantation mit Treosulfan- oder Melphalanbasierter Konditionierung bei Kindern und Jugendlichen mit primärer Hämophagozytischer Lymphohistiozytose
Wustrau K, Albert M, Bader P, Beier R, Burkhardt B, Chada M, Greil J, Gruhn B, Kühl J, Lang P, Meisel R, Schulz A, Seidel M, Speckmann C, Sykora K, Wawer A, Wößmann W, Ozga A, Janka-Schaub G, Ehl S, Müller I, Lehmberg K
2019. Monatsschrift Kinderheilkunde > Ausgabe 7/2018 . 646-647.
2018
Allogeneic haematopoietic stem cell transplantation eliminates alloreactive inhibitory antibodies after liver transplantation for bile salt export pump deficiency
Brinkert F, Pukite I, Krebs-Schmitt D, Briem-Richter A, Stindt J, Häussinger D, Keitel V, Müller I, Grabhorn E
J HEPATOL. 2018;69(4):961-965.
Lysosomal Proteome and Secretome Analysis Identifies Missorted Enzymes and Their Nondegraded Substrates in Mucolipidosis III Mouse Cells
Di Lorenzo G, Velho R, Winter D, Thelen M, Ahmadi S, Schweizer M, De Pace R, Cornils K, Yorgan T, Grüb S, Hermans-Borgmeyer I, Schinke T, Müller-Loennies S, Braulke T, Pohl S
MOL CELL PROTEOMICS. 2018;17(8):1612-1626.
Recommendations for the Use of Etoposide-Based Therapy and Bone Marrow Transplantation for the Treatment of HLH: Consensus Statements by the HLH Steering Committee of the Histiocyte Society
Ehl S, Astigarraga I, von Bahr Greenwood T, Hines M, Horne A, Ishii E, Janka G, Jordan M, La Rosée P, Lehmberg K, Machowicz R, Nichols K, Sieni E, Wang Z, Henter J
J ALLER CL IMM-PRACT. 2018;6(5):1508-1517.
T-cell gene therapy for perforin deficiency corrects cytotoxicity defects and prevents hemophagocytic lymphohistiocytosis manifestations
Ghosh S, Carmo M, Calero-Garcia M, Ricciardelli I, Bustamante Ogando J, Blundell M, Schambach A, Ashton-Rickardt P, Booth C, Ehl S, Lehmberg K, Thrasher A, Gaspar H
J ALLERGY CLIN IMMUN. 2018;142(3):904-913.
Is an infectious trigger always required for primary hemophagocytic lymphohistiocytosis? Lessons from in utero and neonatal disease
Heeg M, Ammann S, Klemann C, Panning M, Falcone V, Hengel H, Lehmberg K, Zur Stadt U, Wustrau K, Janka G, Ehl S
PEDIATR BLOOD CANCER. 2018;65(11):e27344.
Hämophagozytische Lymphohistiozytose
Lehmberg K
2018. Referenz Hämatologie. Kreuzer K (Hrsg.). Georg Thieme Verlag KG, .
Histiozytäre Erkrankungen
Lehmberg K
2018. Pädiatrische Hämatologie und Onkologie. Niemeyer C, Eggert A (Hrsg.). 2. Aufl. Springer, .
Neuroimaging findings in children with hereditary hemophagocytic lymphohistiocytosis – report from the German reference center
Löbel U, Wustrau K, Müller I, Janka-Schaub G, Fiehler J, Lehmberg K
2018. NeuroRAD 2018 - 53. Jahrestagung der Deutschen Gesellschaft für Neuroradiologe e.V.. .
Treatment dilemmas in asymptomatic children with primary hemophagocytic lymphohistiocytosis
Lucchini G, Marsh R, Gilmour K, Worth A, Nademi Z, Rao A, Booth C, Amrolia P, Silva J, Chiesa R, Wynn R, Lehmberg K, Astigarraga I, Güngör T, Stary J, Moshous D, Ifversen M, Zinn D, Jordan M, Kumar A, Yasumi T, Veys P, Rao K
BLOOD. 2018;132(19):2088-2096.
A track of the clones: new developments in cellular barcoding
Lyne A, Kent D, Laurenti E, Cornils K, Glauche I, Perié L
EXP HEMATOL. 2018;68:15-20.
CD34+ selected stem cell boosts can improve poor graft function after paediatric allogeneic stem cell transplantation
Mainardi C, Ebinger M, Enkel S, Feuchtinger T, Teltschik H, Eyrich M, Schumm M, Rabsteyn A, Schlegel P, Seitz C, Schwarze C, Müller I, Greil J, Bader P, Schlegel P, Martin D, Holzer U, Döring M, Handgretinger R, Lang P
BRIT J HAEMATOL. 2018;180(1):90-99.
Autoinflammatory mutation in NLRC4 reveals a leucine-rich repeat (LRR)-LRR oligomerization interface
Moghaddas F, Zeng P, Zhang Y, Schützle H, Brenner S, Hofmann S, Berner R, Zhao Y, Lu B, Chen X, Zhang L, Cheng S, Winkler S, Lehmberg K, Canna S, Czabotar P, Wicks I, De Nardo D, Hedrich C, Zeng H, Masters S
J ALLERGY CLIN IMMUN. 2018;142(6):1956-1967.e6.
Autologous Mesenchymal Stroma Cells Are Superior to Allogeneic Ones in Bone Defect Regeneration
Rapp A, Bindl R, Erbacher A, Kruchen A, Rojewski M, Schrezenmeier H, Müller I, Ignatius A
INT J MOL SCI. 2018;19(9):.
Cellular Barcoding Identifies Clonal Substitution as a Hallmark of Local Recurrence in a Surgical Model of Head and Neck Squamous Cell Carcinoma
Roh V, Abramowski P, Hiou-Feige A, Cornils K, Rivals J, Zougman A, Aranyossy T, Thielecke L, Truan Z, Mermod M, Monnier Y, Prassolov V, Glauche I, Nowrouzi A, Abdollahi A, Fehse B, Simon C, Tolstonog G
CELL REP. 2018;25(8):2208-2222.e7.
Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge
Shemer A, Grozovski J, Tay T, Tao J, Volaski A, Süß P, Ardura-Fabregat A, Gross-Vered M, Kim J, David E, Chappell-Maor L, Thielecke L, Glass C, Cornils K, Prinz M, Jung S
NAT COMMUN. 2018;9(1):5206.
High bone turnover in mice carrying a pathogenic Notch2-mutation causing Hajdu-Cheney syndrome
Vollersen N, Hermans-Borgmeyer I, Cornils K, Fehse B, Rolvien T, Triviai I, Jeschke A, Oheim R, Amling M, Schinke T, Yorgan T
J BONE MINER RES. 2018;33(1):70-83.
Risk factors for mixed chimerism after stem cell transplantation with treosulfan or melphalan based conditioning regimens in children and adolescents with primary hemophagocytic lymphohistocytosis
Wustrau K, Albert M, Bader P, Beier R, Burkhardt B, Chada M, Greil J, Gruhn B, Kühl J, Lang P, Meisel R, Schulz A, Seidel M, Speckmann C, Sykora K, Wawer A, Wößmann W, Ozga A, Ehl S, Müller I, Lehmberg K
2018. Bone Marrow Transplantation (2018) Abstracts Collection. .
2017
Enzymatic characterization of novel arylsulfatase A variants using human arylsulfatase A-deficient immortalized mesenchymal stromal cells
Böhringer J, Santer R, Schumacher N, Gieseke F, Cornils K, Pechan M, Kustermann-Kuhn B, Handgretinger R, Schöls L, Harzer K, Krägeloh-Mann I, Müller I
HUM MUTAT. 2017;38(11):1511-1520.
Clonal competition in BcrAbl-driven leukemia: how transplantations can accelerate clonal conversion
Cornils K, Thielecke L, Winkelmann D, Aranyossy T, Lesche M, Dahl A, Roeder I, Fehse B, Glauche I
MOL CANCER. 2017;16(1):120.
Efficacy, safety and feasibility of antifungal prophylaxis with posaconazole tablet in paediatric patients after haematopoietic stem cell transplantation
Döring M, Cabanillas Stanchi K, Queudeville M, Feucht J, Blaeschke F, Schlegel P, Feuchtinger T, Lang P, Müller I, Handgretinger R, Heinz W
J CANCER RES CLIN. 2017;143(7):1281-1292.
Hematopoietic stem cell transplantation rescues the hematological, immunological and vascular phenotype in DADA2
Hashem H, Kumar A, Müller I, Babor F, Bredius R, Dalal J, Hsu A, Holland S, Hickstein D, Jolles S, Krance R, Sasa G, Taskinen M, Koskenvuo M, Saarela J, van Montfrans J, Wilson K, Bosch B, Moens L, Hershfield M, Meyts I
BLOOD. 2017;130(24):2682-2688.
Hemophagocytic lymphohistiocytosis as presenting manifestation of profound combined immunodeficiency due to an ORAI1 mutation
Klemann C, Ammann S, Heizmann M, Fuchs S, Bode S, Heeg M, Fuchs H, Lehmberg K, Zur Stadt U, Roll C, Vraetz T, Speckmann C, Lorenz M, Schwarz K, Rohr J, Feske S, Ehl S
J ALLERGY CLIN IMMUN. 2017;140(6):1721-1724.
Evolution of disease activity and biomarkers on and off rapamycin in 28 patients with autoimmune lymphoproliferative syndrome
Klemann C, Esquivel M, Magerus-Chatinet A, Lorenz M, Fuchs I, Neveux N, Castelle M, Rohr J, Bettoni da Cunha C, Ebinger M, Kobbe R, Kremens B, Kollert F, Gambineri E, Lehmberg K, Seidel M, Siepermann K, Voelker T, Schuster V, Goldacker S, Schwarz K, Speckmann C, Picard C, Fischer A, Rieux-Laucat F, Ehl S, Rensing-Ehl A, Neven B
HAEMATOLOGICA. 2017;102(2):e52-e56.
Inherited Thrombotic Thrombocytopenic Purpura (Upshaw Schulman Syndrome) as Differential Diagnosis to Neonatal Septicaemia with Disseminated Intravascular Coagulation - a Case Series
Lehmberg K, Hassenpflug W, Klaassen I, Hillebrand G, Oyen F, Budde U, Singer D, Schneppenheim R
Z GEBURTSH NEONATOL. 2017;221(1):39-42.
Measles virus envelope pseudotyped lentiviral vectors transduce quiescent human HSCs at an efficiency without precedent
Lévy C, Amirache F, Girard-Gagnepain A, Frecha C, Roman-Rodríguez F, Bernadin O, Costa C, Nègre D, Gutierrez-Guerrero A, Vranckx L, Clerc I, Taylor N, Thielecke L, Cornils K, Bueren J, Rio P, Gijsbers R, Cosset F, Verhoeyen E
BLOOD ADV. 2017;1(23):2088-2104.
Development and Initial Validation of the Macrophage Activation Syndrome/Primary Hemophagocytic Lymphohistiocytosis Score, a Diagnostic Tool that Differentiates Primary Hemophagocytic Lymphohistiocytosis from Macrophage Activation Syndrome
Minoia F, Bovis F, Davì S, Insalaco A, Lehmberg K, Shenoi S, Weitzman S, Espada G, Gao Y, Anton J, Kitoh T, Kasapcopur O, Sanner H, Merino R, Astigarraga I, Alessio M, Jeng M, Chasnyk V, Nichols K, Huasong Z, Li C, Micalizzi C, Ruperto N, Martini A, Cron R, Ravelli A, Horne A
J PEDIATR-US. 2017;189:72-78.e3.
Mutations in EXTL3 Cause Neuro-immuno-skeletal Dysplasia Syndrome
Oud M, Tuijnenburg P, Hempel M, van Vlies N, Ren Z, Ferdinandusse S, Jansen M, Santer R, Johannsen J, Bacchelli C, Alders M, Li R, Davies R, Dupuis L, Cale C, Wanders R, Pals S, Ocaka L, James C, Müller I, Lehmberg K, Strom T, Engels H, Williams H, Beales P, Roepman R, Dias P, Brunner H, Cobben J, Hall C, Hartley T, Le Quesne Stabej P, Mendoza-Londono R, Davies E, de Sousa S, Lessel D, Arts H, Kuijpers T
AM J HUM GENET. 2017;100(2):281-296.
Limitations and challenges of genetic barcode quantification
Thielecke L, Aranyossy T, Dahl A, Tiwari R, Roeder I, Geiger H, Fehse B, Glauche I, Cornils K
SCI REP-UK. 2017;7:43249.
Multi-color RGB marking enables clonality assessment of liver tumors in a murine xenograft model
Thomaschewski M, Riecken K, Unrau L, Volz T, Cornils K, Ittrich H, Heim D, Wege H, Akgün E, Lütgehetmann M, Dieckhoff J, Köpke M, Dandri M, Benten D, Fehse B
ONCOTARGET. 2017;8(70):115582-115595.
Lineage switch under blinatumomab treatment of relapsed common acute lymphoblastic leukemia without MLL rearrangement
Zoghbi A, Zur Stadt U, Winkler B, Müller I, Escherich G
PEDIATR BLOOD CANCER. 2017;64(11):11.
2016
Investigation of the Mesenchymal Stem Cell Compartment by Means of a Lentiviral Barcode Library
Bigildeev A, Cornils K, Aranyossy T, Sats N, Petinati N, Shipounova I, Surin V, Pshenichnikova O, Riecken K, Fehse B, Drize N
BIOCHEMISTRY-MOSCOW+. 2016;81(4):373-81.
Feasibility of CD3/CD19 depletion of a bone marrow graft
Bonig H, Müller I
CYTOTHERAPY. 2016;18(10):1345-7.
Treatment and outcome of Ganglioneuroma and Ganglioneuroblastoma intermixed
Decarolis B, Simon T, Krug B, Leuschner I, Vokuhl C, Kaatsch P, von Schweinitz D, Klingebiel T, Müller I, Schweigerer L, Berthold F, Hero B
BMC CANCER. 2016;16:542.
Ferritin as an early marker of graft rejection after allogeneic hematopoietic stem cell transplantation in pediatric patients
Döring M, Cabanillas Stanchi K, Feucht J, Queudeville M, Teltschik H, Lang P, Feuchtinger T, Handgretinger R, Müller I
ANN HEMATOL. 2016;95(2):311-23.
Indication of Horizontal DNA Gene Transfer by Extracellular Vesicles
Fischer S, Cornils K, Speiseder T, Badbaran A, Reimer R, Indenbirken D, Grundhoff A, Brunswig-Spickenheier B, Alawi M, Lange C
PLOS ONE. 2016;11(9):e0163665.
Long-term Outcome of Allogeneic Hematopoietic Stem Cell Transplantation in Patients With Juvenile Metachromatic Leukodystrophy Compared With Nontransplanted Control Patients
Groeschel S, Kühl J, Bley A, Kehrer C, Weschke B, Döring M, Böhringer J, Schrum J, Santer R, Kohlschütter A, Krägeloh-Mann I, Müller I
JAMA NEUROL. 2016;73(9):1133-40.
The minimum required level of donor chimerism in hereditary hemophagocytic lymphohistiocytosis
Hartz B, Marsh R, Rao K, Henter J, Jordan M, Filipovich L, Bader P, Beier R, Burkhardt B, Meisel R, Schulz A, Winkler B, Albert M, Greil J, Karasu G, Woessmann W, Corbaciologlu S, Gruhn B, Holter W, Kühl J, Lang P, Seidel M, Veys P, Löfstedt A, Ammann S, Ehl S, Janka G, Müller I, Lehmberg K
BLOOD. 2016;127(25):3281-90.
Treosulfan based conditioning for allogeneic HSCT in children with chronic granulomatous disease: a multicentre experience
Morillo-Gutierrez B, Beier R, Rao K, Burroughs L, Schulz A, Ewins A, Gibson B, Sedlacek P, Krol L, Strahm B, Zaidman I, Kalwak K, Talano J, Woolfrey A, Fraser C, Meyts I, Müller I, Wachowiak J, Bernardo M, Veys P, Sykora K, Gennery A, Slatter M
BLOOD. 2016;128(3):440-8.
Fracture Healing Is Delayed in Immunodeficient NOD/scid‑IL2Rγcnull Mice
Rapp A, Bindl R, Recknagel S, Erbacher A, Müller I, Schrezenmeier H, Ehrnthaller C, Gebhard F, Ignatius A
PLOS ONE. 2016;11(2):e0147465.
Expert consensus on dynamics of laboratory tests for diagnosis of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis
Ravelli A, Minoia F, Davì S, Horne A, Bovis F, Pistorio A, Aricò M, Avcin T, Behrens E, De Benedetti F, Filipovic A, Grom A, Henter J, Ilowite N, Jordan M, Khubchandani R, Kitoh T, Lehmberg K, Lovell D, Miettunen P, Nichols K, Ozen S, Pachlopnik Schmid J, Ramanan A, Russo R, Schneider R, Sterba G, Uziel Y, Wallace C, Wouters C, Wulffraat N, Demirkaya E, Brunner H, Martini A, Ruperto N, Cron R
BMJ OPEN. 2016;2(1):e000161.
2016 Classification Criteria for Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis: A European League Against Rheumatism/American College of Rheumatology/Paediatric Rheumatology International Trials Organisation Collaborative Initiative
Ravelli A, Minoia F, Davì S, Horne A, Bovis F, Pistorio A, Aricò M, Avcin T, Behrens E, De Benedetti F, Filipovic L, Grom A, Henter J, Ilowite N, Jordan M, Khubchandani R, Kitoh T, Lehmberg K, Lovell D, Miettunen P, Nichols K, Ozen S, Pachlopnik Schmid J, Ramanan A, Russo R, Schneider R, Sterba G, Uziel Y, Wallace C, Wouters C, Wulffraat N, Demirkaya E, Brunner H, Martini A, Ruperto N, Cron R
ANN RHEUM DIS. 2016;75(3):481-9.
Musculoskeletal manifestations in mucopolysaccharidosis type I (Hurler syndrome) following hematopoietic stem cell transplantation
Schmidt M, Breyer S, Löbel U, Yarar S, Stücker R, Ullrich K, Müller I, Muschol N
ORPHANET J RARE DIS. 2016;11(1):93.
Massive Clonal Selection and Transiently Contributing Clones During Expansion of Mesenchymal Stem Cell Cultures Revealed by Lentiviral RGB-Barcode Technology
Selich A, Daudert J, Hass R, Philipp F, von Kaisenberg C, Paul G, Cornils K, Fehse B, Rittinghausen S, Schambach A, Rothe M
STEM CELL TRANSL MED. 2016;5(5):591-601.
EZH2 mutation in an adolescent with Weaver syndrome developing acute myeloid leukemia and secondary hemophagocytic lymphohistiocytosis
Usemann J, Ernst T, Schäfer V, Lehmberg K, Seeger K
AM J MED GENET A. 2016;170(5):1274-7.
2015
Monitoring of Minimal Residual Disease After Allogeneic Stem-Cell Transplantation in Relapsed Childhood Acute Lymphoblastic Leukemia Allows for the Identification of Impending Relapse: Results of the ALL-BFM-SCT 2003 Trial
Bader P, Kreyenberg H, von Stackelberg A, Eckert C, Salzmann-Manrique E, Meisel R, Poetschger U, Stachel D, Schrappe M, Alten J, Schrauder A, Schulz A, Lang P, Müller I, Albert M, Willasch A, Klingebiel T, Peters C
J CLIN ONCOL. 2015;33(11):1275 - 84.
Consensus of German transplant centers on hematopoietic stem cell transplantation in Fanconi anemia
Chao M, Ebell W, Bader P, Beier R, Burkhardt B, Feuchtinger T, Handgretinger R, Hanenberg H, Koehl U, Kratz C, Kremens B, Lang P, Meisel R, Müller I, Roessig C, Sauer M, Schlegel P, Schulz A, Strahm B, Thol F, Sykora K
KLIN PADIATR. 2015;227(3):157-65.
Cytokine serum levels during post-transplant adverse events in 61 pediatric patients after hematopoietic stem cell transplantation
Döring M, Cabanillas Stanchi K, Mezger M, Erbacher A, Feucht J, Pfeiffer M, Lang P, Handgretinger R, Müller I
BMC CANCER. 2015;15:Art. 607.
Antifungal prophylaxis with posaconazole vs. fluconazole or itraconazole in pediatric patients with neutropenia
Döring M, Eikemeier M, Cabanillas Stanchi K, Hartmann U, Ebinger M, Schwarze C, Schulz A, Handgretinger R, Müller I
EUR J CLIN MICROBIOL. 2015;34(6):1189-1200.
Retroviral insertional mutagenesis in telomerase-immortalized hepatocytes identifies RIPK4 as novel tumor suppressor in human hepatocarcinogenesis
Heim D, Cornils K, Schulze K, Fehse B, Lohse A, Brümmendorf T, Wege H
ONCOGENE. 2015;34(3):385-393.
Multipotent Mesenchymal Stromal Cells: Possible Culprits in Solid Tumors?
Johann P, Müller I
Stem Cells Int. 2015;2015:914632.
Risk of Rotavirus Vaccination for Children with SCID
Klinkenberg D, Blohm M, Hoehne M, Mas Marques A, Malecki M, Schildgen V, Schneppenheim R, Müller I, Schildgen O, Kobbe R
PEDIATR INFECT DIS J. 2015;34(1):114-5.
Donor choice in haploidentical stem cell transplantation: fetal microchimerism is associated with better outcome in pediatric leukemia patients
Kruchen A, Stahl T, Gieseke F, Binder T, Özcan Z, Meisel R, Kreyenberg H, Bader P, Gruhn B, Greil J, Pfeiffer M, Döring M, Handgretinger R, Fehse B, Müller I
BONE MARROW TRANSPL. 2015;50(10):1367-1370.
Out of the haemophagocytic lymphohistiocytosis niche
Lehmberg K
LANCET HAEMATOL. 2015;2(12):e508-9.
Consensus recommendations for the diagnosis and management of hemophagocytic lymphohistiocytosis associated with malignancies
Lehmberg K, Nichols K, Henter J, Girschikofsky M, Greenwood T, Jordan M, Kumar A, Minkov M, La Rosée P, Weitzman S
HAEMATOLOGICA. 2015;100(8):997-1004.
Malignancy-associated haemophagocytic lymphohistiocytosis in children and adolescents
Lehmberg K, Sprekels B, Nichols K, Woessmann W, Müller I, Suttorp M, Bernig T, Beutel K, Bode S, Kentouche K, Kolb R, Längler A, Minkov M, Schilling F, Schmid I, Vieth S, Ehl S, Zur Stadt U, Janka G
BRIT J HAEMATOL. 2015;170(4):539-49.
Lrp1/LDL receptor play critical roles in mannose 6-phosphate-independent lysosomal enzyme targeting
Markmann S, Thelen M, Cornils K, Schweizer M, Brocke-Ahmadinejad N, Willnow T, Heeren J, Gieselmann V, Braulke T, Kollmann K
TRAFFIC. 2015.
Klinische Praxis - Spenderfindung und Stammzelltransplantation
Müller I
2015. Rettende Geschwister. Schües C, Rehmann-Sutter C (Hrsg.). 2015. Aufl. Münster: Mentis, 25 - 32.
Systemic mesenchymal stem cell administration enhances bone formation in fracture repair but not load-induced bone formation
Rapp A, Bindl R, Heilmann A, Erbacher A, Müller I, Brenner R, Ignatius A
EUR CELLS MATER. 2015;29:22-34.
Standardization of Good Manufacturing Practice-compliant production of bone marrow-derived human mesenchymal stromal cells for immunotherapeutic applications
Wuchter P, Bieback K, Schrezenmeier H, Bornhäuser M, Müller L, Bönig H, Wagner W, Meisel R, Pavel P, Tonn T, Lang P, Müller I, Renner M, Malcherek G, Saffrich R, Buss E, Horn P, Rojewski M, Schmitt A, Ho A, Sanzenbacher R, Schmitt M
CYTOTHERAPY. 2015;17(2):128-139.
2014
Comparison of itraconazole, voriconazole, and posaconazole as oral antifungal prophylaxis in pediatric patients following allogeneic hematopoietic stem cell transplantation
Döring M, Blume O, Haufe S, Hartmann U, Kimmig A, Schwarze C, Lang P, Handgretinger R, Müller I
EUR J CLIN MICROBIOL. 2014;33(4):629-38.
Hemophagocytic syndromes - An update
Janka-Schaub G, Lehmberg K
BLOOD REV. 2014;28(4):135-142.
Transplantation of CD3/CD19 depleted allografts from haploidentical family donors in paediatric leukaemia
Lang P, Teltschik H, Feuchtinger T, Müller I, Pfeiffer M, Schumm M, Ebinger M, Schwarze C, Gruhn B, Schrauder A, Albert M, Greil J, Urban C, Handgretinger R
BRIT J HAEMATOL. 2014;165(5):688-98.
Treosulfan-based conditioning regimen for children and adolescents with hemophagocytic lymphohistiocytosis
Lehmberg K, Albert M, Beier R, Beutel K, Gruhn B, Kröger N, Meisel R, Schulz A, Stachel D, Woessmann W, Janka G, Müller I
HAEMATOLOGICA. 2014;99(1):180-4.
Determination of an appropriate cut-off value for ferritin in the diagnosis of hemophagocytic lymphohistiocytosis
Lehmberg K, McClain K, Janka-Schaub G, Allen C
PEDIATR BLOOD CANCER. 2014.
Clinical features, treatment, and outcome of macrophage activation syndrome complicating systemic juvenile idiopathic Arthritis: a multinational, multicenter study of 362 patients
Minoia F, Davì S, Horne A, Demirkaya E, Bovis F, Li C, Lehmberg K, Weitzman S, Insalaco A, Wouters C, Shenoi S, Espada G, Ozen S, Anton J, Khubchandani R, Russo R, Pal P, Kasapcopur O, Miettunen P, Maritsi D, Merino R, Shakoory B, Alessio M, Chasnyk V, Sanner H, Gao Y, Huasong Z, Kitoh T, Avcin T, Fischbach M, Frosch M, Grom A, Huber A, Jelusic M, Sawhney S, Uziel Y, Ruperto N, Martini A, Cron R, Ravelli A
ARTHRITIS RHEUMATOL. 2014;66(11):3160-9.
Signal-peptide-peptidase-like 2a is required for CD74 intramembrane proteolysis in human B cells
Schneppenheim J, Hüttl S, Kruchen A, Fluhrer R, Müller I, Saftig P, Schneppenheim R, Martin C, Schröder B
BIOCHEM BIOPH RES CO. 2014;451(1):48-53.
2013
Allo-SCT using BU, CY and melphalan for children with AML in second CR
Beier R, Albert M, Bader P, Borkhardt A, Creutzig U, Eyrich M, Ehlert K, Gruhn B, Greil J, Handgretinger R, Holter W, Klingebiel T, Kremens B, Lang P, Mauz-Körholz C, Meisel R, Müller I, Peters C, Reinhardt D, Sedlacek P, Schulz A, Schuster F, Schrauder A, Strahm B, Sykora K, Wössmann W, Zimmermann M, Sauer M
BONE MARROW TRANSPL. 2013;48(5):651-6.
Long-term follow-up of children conditioned with Treosulfan: German and Austrian experience
Beier R, Schulz A, Hönig M, Eyrich M, Schlegel P, Holter W, Stachel K, Ehlert K, Greil J, Nürnberger W, Wössmann W, Bader P, Urban C, Müller I, Suttorp M, Sauer M, Gruhn B, Meisel R, Zimmermann M, Sykora K
BONE MARROW TRANSPL. 2013;48(4):491-501.
Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation
Gieseke F, Kruchen A, Tzaribachev N, Bentzien F, Dominici M, Müller I
EUR J IMMUNOL. 2013;43(10):2741-9.
Activated human hepatic stellate cells induce myeloid derived suppressor cells from peripheral blood monocytes in a CD44-dependent fashion
Höchst B, Schildberg F, Sauerborn P, Gäbel Y, Gevensleben H, Goltz D, Heukamp L, Türler A, Ballmaier M, Gieseke F, Müller I, Kalff J, Kurts C, Knolle P, Diehl L
J HEPATOL. 2013;59(3):528-35.
One goal, different strategies--molecular and cellular approaches for the treatment of inherited skin fragility disorders
Hünefeld C, Mezger M, Kern J, Nyström A, Bruckner-Tuderman L, Müller I, Handgretinger R, Röcken M
EXP DERMATOL. 2013;22(3):162-7.
Hemophagocytic lymphohistiocytosis - pathogenesis and treatment
Janka-Schaub G, Lehmberg K
HEMATOL-AM SOC HEMAT. 2013;2013:605-11.
The risk of hemophagocytic lymphohistiocytosis in Hermansky-Pudlak syndrome type 2
Jessen B, Bode S, Ammann S, Chakravorty S, Davies G, Diestelhorst J, Frei-Jones M, Gahl W, Gochuico B, Griese M, Griffiths G, Janka-Schaub G, Klein C, Kögl T, Kurnik K, Lehmberg K, Maul-Pavicic A, Mumford A, Pace D, Parvaneh N, Rezaei N, de Saint Basile G, Schmitt-Graeff A, Schwarz K, Karasu G, Zieger B, zur Stadt U, Aichele P, Ehl S
BLOOD. 2013;121(15):2943-51.
Juvenile metachromatic leukodystrophy 10 years post transplant compared with a non-transplanted cohort
Krägeloh-Mann I, Groeschel S, Kehrer C, Opherk K, Nägele T, Handgretinger R, Müller I
BONE MARROW TRANSPL. 2013;48(3):369-75.
Diagnostic evaluation of patients with suspected haemophagocytic lymphohistiocytosis.
Lehmberg K, Ehl S
BRIT J HAEMATOL. 2013;160(3):275-287.
Administration of recombinant erythropoietin alone does not improve the phenotype in iron refractory iron deficiency anemia patients.
Lehmberg K, Grosse R, Muckenthaler M, Altamura S, Nielsen P, Schmid H, Graubner U, Oyen F, Zeller W, Schneppenheim R, Janka-Schaub G
ANN HEMATOL. 2013;92(3):387-394.
Differentiating macrophage activation syndrome in systemic juvenile idiopathic arthritis from other forms of hemophagocytic lymphohistiocytosis
Lehmberg K, Pink I, zu Eulenburg C, Beutel K, Maul-Pavicic A, Janka-Schaub G
J PEDIATR-US. 2013;162(6):1245-51.
Allogeneic hematopoietic cell transplantation for XIAP deficiency: an international survey reveals poor outcomes.
Marsh R, Rao K, Satwani P, Lehmberg K, Müller I, Li D, Kim M, Fischer A, Latour S, Sedlacek P, Barlogis V, Hamamoto K, Kanegane H, Milanovich S, Margolis D, Dimmock D, Casper J, Douglas D, Amrolia P, Veys P, Kumar A, Jordan M, Bleesing J, Filipovich A
BLOOD. 2013;121(6):877-883.
Outcome of allogeneic SCT in patients with chronic myeloid leukemia in the era of tyrosine kinase inhibitor therapy.
Oyekunle A, Zander A, Binder M, Ayuketang F, Zabelina T, Christopeit M, Stübig T, Alchalby H, Schafhausen P, Lellek H, Wolschke C, Müller I, Bacher U, Kröger N
ANN HEMATOL. 2013;92(4):487-496.
Sequential decisions on FAS sequencing guided by biomarkers in patients with lymphoproliferation and autoimmune cytopenia
Rensing-Ehl A, Janda A, Lorenz M, Gladstone B, Fuchs I, Abinun M, Albert M, Butler K, Cant A, Cseh A, Ebinger M, Goldacker S, Hambleton S, Hebart H, Houet L, Kentouche K, Kühnle I, Lehmberg K, Mejstrikova E, Niemeyer C, Minkov M, Neth O, Dückers G, Owens S, Rösler J, Schilling F, Schuster V, Seidel M, Smisek P, Sukova M, Svec P, Wiesel T, Gathmann B, Schwarz K, Vach W, Ehl S, Speckmann C
HAEMATOLOGICA. 2013;98(12):1948-55.
X-linked inhibitor of apoptosis (XIAP) deficiency: the spectrum of presenting manifestations beyond hemophagocytic lymphohistiocytosis
Speckmann C, Lehmberg K, Albert M, Damgaard R, Fritsch M, Gyrd-Hansen M, Rensing-Ehl A, Vraetz T, Grimbacher B, Salzer U, Fuchs I, Ufheil H, Belohradsky B, Hassan A, Cale C, Elawad M, Strahm B, Schibli S, Lauten M, Kohl M, Meerpohl J, Rodeck B, Kolb R, Eberl W, Soerensen J, von Bernuth H, Lorenz M, Schwarz K, zur Stadt U, Ehl S
CLIN IMMUNOL. 2013;149(1):133-41.
Persistent defective membrane trafficking in epithelial cells of patients with familial hemophagocytic lymphohistiocytosis type 5 due to STXBP2/MUNC18-2 mutations
Stepensky P, Bartram J, Barth T, Lehmberg K, Walther P, Amann K, Philips A, Beringer O, zur Stadt U, Schulz A, Amrolia P, Weintraub M, Debatin K, Hoenig M, Posovszky C
PEDIATR BLOOD CANCER. 2013;60(7):1215-22.
Clinical phenotype and functional analysis of a rare XIAP/BIRC4 mutation
Vieth S, Ammann S, Schwarz K, Härtel C, Schultz C, Lehmberg K, Lauten M
KLIN PADIATR. 2013;225(6):343-6.
2012
Defibrotide for prophylaxis of hepatic veno-occlusive disease in paediatric haemopoietic stem-cell transplantation: an open-label, phase 3, randomised controlled trial.
Corbacioglu S, Cesaro S, Faraci M, Valteau-Couanet D, Gruhn B, Rovelli A, Boelens J, Hewitt A, Schrum J, Schulz A, Müller I, Stein J, Wynn R, Greil J, Sykora K, Matthes-Martin S, Führer M, O'Meara A, Toporski J, Sedlacek P, Schlegel P, Ehlert K, Fasth A, Winiarski J, Arvidson J, Mauz-Körholz C, Ozsahin H, Schrauder A, Bader P, Massaro J, D'Agostino R, Hoyle M, Iacobelli M, Debatin K, Peters C, Dini G
LANCET. 2012;379(9823):1301-1309.
Caspofungin as antifungal prophylaxis in pediatric patients undergoing allogeneic hematopoietic stem cell transplantation: a retrospective analysis.
Döring M, Hartmann U, Erbacher A, Lang P, Handgretinger R, Müller I
BMC INFECT DIS. 2012;12:151.
Analysis of posaconazole as oral antifungal prophylaxis in pediatric patients under 12 years of age following allogeneic stem cell transplantation.
Döring M, Müller C, Johann P, Erbacher A, Kimmig A, Schwarze C, Lang P, Handgretinger R, Müller I
BMC INFECT DIS. 2012;12:263.
Eradication of pulmonary aspergillosis in an adolescent patient undergoing three allogeneic stem cell transplantations for acute lymphoblastic leukemia.
Döring M, Zierl A, Mezger M, Lang P, Handgretinger R, Müller I
Case reports in transplantation. 2012;2012:672923.
Siglec-7 tetramers characterize B-cell subpopulations and leukemic blasts.
Gieseke F, Mang P, Viebahn S, Sonntag I, Kruchen A, Erbacher A, Pfeiffer M, Handgretinger R, Müller I
EUR J IMMUNOL. 2012;42(8):2176-2186.
Basic biology and clinical application of multipotent mesenchymal stromal cells: from bench to bedside.
Kuçi S, Henschler R, Müller I, Biagi E, Meisel R
Stem Cells Int. 2012;2012:185943.
Distinct mutations in STXBP2 are associated with variable clinical presentations in patients with familial hemophagocytic lymphohistiocytosis type 5 (FHL5)
Pagel J, Beutel K, Lehmberg K, Koch F, Maul-Pavicic A, Rohlfs A, Al-Jefri A, Beier R, Lilian B, Ehlert K, Gross-Wieltsch U, Jorch N, Kremens B, Pekrun A, Sparber-Sauer M, Mejstrikova E, Wawer A, Ehl S, Zur Stadt U, Janka-Schaub G
BLOOD. 2012;119(25):6016-6024.
IL-15-stimulated CD3/CD19-depleted stem-cell boosts in relapsed pediatric patients after haploidentical SCT.
Pfeiffer M, Schumm M, Müller I, Handgretinger R, Lang P
LEUKEMIA. 2012;26(11):2435-2439.
Risk factors for early death in children with haemophagocytic lymphohistiocytosis.
Trottestam H, Berglöf E, Horne A, Onelöv E, Beutel K, Lehmberg K, Sieni E, Silfverberg T, Aricò M, Janka-Schaub G, Henter J
ACTA PAEDIATR. 2012;101(3):313-318.
2011
Subtle differences in CTL cytotoxicity determine susceptibility to hemophagocytic lymphohistiocytosis in mice and humans with Chediak-Higashi syndrome.
Jessen B, Maul-Pavicic A, Ufheil H, Vraetz T, Enders A, Lehmberg K, Längler A, Gross-Wieltsch U, Bay A, Kaya Z, Bryceson Y, Koscielniak E, Badawy S, Davies G, Hufnagel M, Schmitt-Graeff A, Aichele P, Zur Stadt U, Schwarz K, Ehl S
BLOOD. 2011;118(17):4620-4629.
Increased cyclosporine concentrations in the absence of cyclosporine administration.
Peter A, Shipkova M, Wieland E, Schleicher E, Müller I
CLIN CHEM. 2011;57(5):670-673.
Mesenchymal stromal cells for treatment of steroid-refractory GvHD: a review of the literature and two pediatric cases.
Wernicke C, Grunewald T, Juenger H, Kuci S, Kuci Z, Koehl U, Müller I, Doering M, Peters C, Lawitschka A, Kolb H, Bader P, Burdach S, von Luettichau I
Int Arch Med. 2011;4(1):27.
2010
Long-term human CD34+ stem cell-engrafted nonobese diabetic/SCID/IL-2R gamma(null) mice show impaired CD8+ T cell maintenance and a functional arrest of immature NK cells
André M, Erbacher A, Gille C, Schmauke V, Goecke B, Hohberger A, Mang P, Wilhelm A, Müller I, Herr W, Lang P, Handgretinger R, Hartwig U
J IMMUNOL. 2010;185(5):2710-20.
Human multipotent mesenchymal stromal cells use galectin-1 to inhibit immune effector cells
Gieseke F, Böhringer J, Bussolari R, Dominici M, Handgretinger R, Müller I
BLOOD. 2010;116(19):3770-9.
Successful autologous stem cell transplantation in two patients with juvenile dermatomyositis
Holzer U, van Royen-Kerkhof A, van der Torre P, Kuemmerle-Deschner J, Well C, Handgretinger R, Müller I, Wulffraat N
SCAND J RHEUMATOL. 2010;39(1):88-92.
Low physiologic oxygen tensions reduce proliferation and differentiation of human multipotent mesenchymal stromal cells
Holzwarth C, Vaegler M, Gieseke F, Pfister S, Handgretinger R, Kerst G, Müller I
BMC CELL BIOL. 2010;11:11.
Tumour stromal cells derived from paediatric malignancies display MSC-like properties and impair NK cell cytotoxicity
Johann P, Vaegler M, Gieseke F, Mang P, Armeanu-Ebinger S, Kluba T, Handgretinger R, Müller I
BMC CANCER. 2010;10:501.
Reconstitution of natural killer cell receptors influences natural killer activity and relapse rate after haploidentical transplantation of T- and B-cell depleted grafts in children
Pfeiffer M, Feuchtinger T, Teltschik H, Schumm M, Müller I, Handgretinger R, Lang P
HAEMATOLOGICA. 2010;95(8):1381-8.
Chronic inflammatory bowel disease as key manifestation of atypical ARTEMIS deficiency
Rohr J, Pannicke U, Döring M, Schmitt-Graeff A, Wiech E, Busch A, Speckmann C, Müller I, Lang P, Handgretinger R, Fisch P, Schwarz K, Ehl S
J CLIN IMMUNOL. 2010;30(2):314-20.
2009
Pancytopenia in a 4-year-old boy. 22q11.2 microdeletion syndrome.
Lehmberg K, Rohr J, Schneppenheim R, Sommerfeld K, Janka-Schaub G
ACTA PAEDIATR. 2009;98(5):769-770, 912-914.
2007
From neonates to adolescents--the diagnostic significance of pitted erythrocytes in hyposplenic and asplenic children.
Lehmberg K, Steinhausen B, Janka-Schaub G
KLIN PADIATR. 2007;219(6):339-342.
Letzte Aktualisierung aus dem FIS: 12.12.2024 - 23:33 Uhr