Protosequences in brain organoids model intrinsic brain states Authors
van der Molen T, Spaeth A, Chini M, Bartram J, Dendukuri A, Zhang Z, Bhaskaran-Nair K, Blauvelt L, Petzold L, Hansma P, Teodorescu M, Hierlemann A, Biology, Washington University in St. Louis, USA D, Hanganu-Opatz I, Kosik K, Sharf T
bioRxiv. 2025.

Protocol for adeno-associated virus-mediated optogenetic activation of olfactory output neurons in neonatal mice
Chen Y, Kostka J, Bitzenhofer S, Hanganu-Opatz I
STAR PROTOC. 2024;5(3):103164.

Preconfigured architecture of the developing mouse brain
Chini M, Hnida M, Kostka J, Chen Y, Hanganu-Opatz I
CELL REP. 2024;43(6):114267.

Blood pressure pulsations modulate central neuronal activity via mechanosensitive ion channels
Jammal Salameh L, Bitzenhofer S, Hanganu-Opatz I, Dutschmann M, Egger V
SCIENCE. 2024;383(6682):eadk8511.

A developmental increase of inhibition promotes the emergence of hippocampal ripples
Pochinok I, Stöber T, Triesch J, Chini M, Hanganu-Opatz I
NAT COMMUN. 2024;15(1):738.

Development of Prefrontal Circuits and Cognitive Abilities
Pöpplau J, Hanganu-Opatz I
CSH PERSPECT BIOL. 2024;16(10):.

Reorganization of adolescent prefrontal cortex circuitry is required for mouse cognitive maturation
Pöpplau J, Schwarze T, Dorofeikova M, Pochinok I, Günther A, Marquardt A, Hanganu-Opatz I
NEURON. 2024;112(3):421-440.e7.

An information-theoretic quantification of the content of communication between brain regions
Celotto M, Bím J, Tlaie A, De Feo V, Toso A, Lemke S, Chicharro D, Nili H, Bieler M, Hanganu-Opatz I, Donner T, Brovelli A, Panzeri S
Advances in Neural Information Processing Systems. 2023;36:.

Olfactory bulb activity shapes the development of entorhinal-hippocampal coupling and associated cognitive abilities
Chen Y, Kostka J, Bitzenhofer S, Hanganu-Opatz I
CURR BIOL. 2023;33(20):4353-4366.e5.

Resolving the prefrontal mechanisms of adaptive cognitive behaviors: A cross-species perspective
Hanganu-Opatz I, Klausberger T, Sigurdsson T, Nieder A, Jacob S, Bartos M, Sauer J, Durstewitz D, Leibold C, Diester I
NEURON. 2023;111(7):1020-1036.

Generation and propagation of bursts of activity in the developing basal ganglia
Klavinskis-Whiting S, Bitzenhofer S, Hanganu-Opatz I, Ellender T
CEREB CORTEX. 2023;33(20):10595-10613.

Olfactory-driven beta band entrainment of limbic circuitry during neonatal development
Kostka J, Hanganu-Opatz I
J PHYSIOL-LONDON. 2023;601(16):3605-3630.

Layer-specific impairment in the developing lateral entorhinal cortex of immune-challenged Disc1+/- mice
Kringel R, Song L, Xu X, Bitzenhofer S, Hanganu-Opatz I
J PHYSIOL-LONDON. 2023;601(4):847-857.

P-126 Spiking network models of developing mouse prefrontal cortex
Lorenz G, Bitzenhofer S, Chini M, Martinez-Canada P, Hanganu-Opatz I, Panzeri S
CLIN NEUROPHYSIOL. 2023;148:e65.

Systems neuroscience: A box full of tools to illuminate the black box of the brain
Wiegert J, Spehr M, Hanganu-Opatz I
PLOS BIOL. 2023;21(7):.

An increase of inhibition drives the developmental decorrelation of neural activity
Chini M, Pfeffer T, Hanganu-Opatz I
ELIFE. 2022;11:.

Calcium imaging and electrophysiology of hippocampal activity under anesthesia and natural sleep in mice
Formozov A, Chini M, Dieter A, Yang W, Pöpplau J, Hanganu-Opatz I, Wiegert J
SCI DATA. 2022;9(1):1-11.

Neuronal oscillations: early biomarkers of psychiatric disease?
Günther A, Hanganu-Opatz I
FRONT BEHAV NEUROSCI. 2022;16:1038981.

TAOK2 rescues autism-linked developmental deficits in a 16p11.2 microdeletion mouse model
Scharrenberg R, Richter M, Johanns O, Meka D, Rücker T, Murtaza N, Lindenmaier Z, Ellegood J, Naumann A, Zhao B, Schwanke B, Sedlacik J, Fiehler J, Hanganu-Opatz I, Lerch J, Singh K, de Anda F
MOL PSYCHIATR. 2022;27(11):4707-4721.

Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice
Schepanski S, Chini M, Sternemann V, Urbschat C, Thiele K, Sun T, Zhao Y, Poburski M, Woestemeier A, Thieme M, Zazara D, Alawi M, Fischer N, Heeren J, Vladimirov N, Woehler A, Puelles V, Bonn S, Gagliani N, Hanganu-Opatz I, Arck P
NAT COMMUN. 2022;13(1):.

Sparser and Less Efficient Hippocampal-Prefrontal Projections account for Developmental Network Dysfunction in a Model of Psychiatric Risk Mediated by Gene-Environment Interaction
Song L, Xu X, Putthoff P, Fleck D, Spehr M, Hanganu-Opatz I
J NEUROSCI. 2022;42(4):601-618.

A transient developmental increase in prefrontal activity alters network maturation and causes cognitive dysfunction in adult mice
Bitzenhofer S, Pöpplau J, Chini M, Marquardt A, Hanganu-Opatz I
NEURON. 2021;109(8):1350-1364.e6.

Prefrontal Cortex Development in Health and Disease: Lessons from Rodents and Humans
Chini M, Hanganu-Opatz I
TRENDS NEUROSCI. 2021;44(3):227-240.

The Logic of Developing Neocortical Circuits in Health and Disease
Hanganu-Opatz I, Butt S, Hippenmeyer S, De Marco García N, Cardin J, Voytek B, Muotri A
J NEUROSCI. 2021;41(5):813-822.

Knock-Down of Hippocampal DISC1 in Immune-Challenged Mice Impairs the Prefrontal-Hippocampal Coupling and the Cognitive Performance Throughout Development
Xu X, Song L, Hanganu-Opatz I
CEREB CORTEX. 2021;31(2):1240-1258.

Developmental decrease of entorhinal-hippocampal communication in immune-challenged DISC1 knockdown mice
Xu X, Song L, Kringel R, Hanganu-Opatz I
NAT COMMUN. 2021;12(1):.

Anesthetics fragment hippocampal network activity, alter spine dynamics, and affect memory consolidation
Yang W, Chini M, Pöpplau J, Formozov A, Dieter A, Piechocinski P, Rais C, Morellini F, Sporns O, Hanganu-Opatz I, Wiegert J
PLOS BIOL. 2021;19(4):e3001146.

Gamma activity accelerates during prefrontal development
Bitzenhofer S, Pöpplau J, Hanganu-Opatz I
ELIFE. 2020;9:e56795.

Resolving and Rescuing Developmental Miswiring in a Mouse Model of Cognitive Impairment
Chini M, Pöpplau J, Lindemann C, Carol-Perdiguer L, Hnida M, Oberländer V, Xu X, Ahlbeck J, Bitzenhofer S, Mulert C, Hanganu-Opatz I
NEURON. 2020;105(1):60-74.e7.

Bursting mitral cells time the oscillatory coupling between olfactory bulb and entorhinal networks in neonatal mice
Kostka J, Gretenkord S, Spehr M, Hanganu-Opatz I
J PHYSIOL-LONDON. 2020;598(24):5753-5769.

Synchronous Infra-Slow Oscillations Organize Ensembles of Accessory Olfactory Bulb Projection Neurons into Distinct Microcircuits
Tsitoura C, Malinowski S, Mohrhardt J, Degen R, DiBenedictis B, Gao Y, Watznauer K, Gerhold K, Nagel M, Weber M, Rothermel M, Hanganu-Opatz I, Ben-Shaul Y, Davison I, Spehr M
J NEUROSCI. 2020;40(21):4203-4218.

Cross-Talk of Low-Level Sensory and High-Level Cognitive Processing: Development, Mechanisms, and Relevance for Cross-Modal Abilities of the Brain
Xu X, Hanganu-Opatz I, Bieler M
FRONT NEUROROBOTICS. 2020;14:7.

Neural Correlates of Anesthesia in Newborn Mice and Humans
Chini M, Gretenkord S, Kostka J, Pöpplau J, Cornelissen L, Berde C, Hanganu-Opatz I, Bitzenhofer S
FRONT NEURAL CIRCUIT. 2019;13:38.

Coordinated electrical activity in the olfactory bulb gates the oscillatory entrainment of entorhinal networks in neonatal mice
Gretenkord S, Kostka J, Hartung H, Watznauer K, Fleck D, Minier-Toribio A, Spehr M, Hanganu-Opatz I
PLOS BIOL. 2019;17(1):e2006994.

Developmental dysfunction of prefrontal-hippocampal networks in mouse models of mental illness
Oberlander V, Xu X, Chini M, Hanganu-Opatz I
EUR J NEUROSCI. 2019;50(6):3072-3084.

Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling
Richter M, Murtaza N, Scharrenberg R, White S, Johanns O, Walker S, Yuen R, Schwanke B, Bedürftig B, Henis M, Scharf S, Kraus V, Dörk R, Hellmann J, Lindenmaier Z, Ellegood J, Hartung H, Kwan V, Sedlacik J, Fiehler J, Schweizer M, Lerch J, Hanganu-Opatz I, Morellini F, Scherer S, Singh K, Calderon de Anda F
MOL PSYCHIATR. 2019;24(9):1329-1350.

Cognitive impairment and autistic-like behaviour in SAPAP4-deficient mice
Schob C, Morellini F, Ohana O, Bakota L, Hrynchak M, Brandt R, Brockmann M, Cichon N, Hartung H, Hanganu-Opatz I, Kraus V, Scharf S, Herrmans-Borgmeyer I, Schweizer M, Kuhl D, Wöhr M, Vörckel K, Calzada-Wack J, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Garner C, Kreienkamp H, Kindler S
TRANSL PSYCHIAT. 2019;9(1):7.

Transient Knock-Down of Prefrontal DISC1 in Immune-Challenged Mice Causes Abnormal Long-Range Coupling and Cognitive Dysfunction throughout Development
Xu X, Chini M, Bitzenhofer S, Hanganu-Opatz I
J NEUROSCI. 2019;39(7):1222-1235.

Glutamatergic drive along the septo-temporal axis of hippocampus boosts prelimbic oscillations in the neonatal mouse
Ahlbeck J, Song L, Chini M, Bitzenhofer S, Hanganu-Opatz I
ELIFE. 2018;7:e33158.

Multisensory integration in rodent tactile but not visual thalamus
Bieler M, Xu X, Marquardt A, Hanganu-Opatz I
SCI REP-UK. 2018;8(1):15684.

WITHDRAWN: P.2.002 Glutamatergic dysfunction within neonatal prefrontal circuitry in a genetic-environmental model of mental disorders
Chinin M, Lindemann C, Pöpplau J, Xu X, Ahlbeck J, Bitzenhofer S, Hanganu-Opatz I
EUR NEUROPSYCHOPHARM. 2018;28 Suppl 1:S22.

Prenatal Immune and Endocrine Modulators of Offspring's Brain Development and Cognitive Functions Later in Life
Schepanski S, Buss C, Hanganu-Opatz I, Arck P
FRONT IMMUNOL. 2018;9:2186.

Tapered Fibers Combined With a Multi-Electrode Array for Optogenetics in Mouse Medial Prefrontal Cortex
Sileo L, Bitzenhofer S, Spagnolo B, Pöpplau J, Holzhammer T, Pisanello M, Pisano F, Bellistri E, Maglie E, De Vittorio M, Ruther P, Hanganu-Opatz I, Pisanello F
FRONT NEUROSCI-SWITZ. 2018;12:771.

Rate and Temporal Coding Convey Multisensory Information in Primary Sensory Cortices
Bieler M, Sieben K, Cichon N, Schildt S, Röder B, Hanganu-Opatz I
ENEURO. 2017;4(2):UNSP e0037.

Visual-tactile processing in primary somatosensory cortex emerges before cross-modal experience
Bieler M, Sieben K, Schildt S, Röder B, Hanganu-Opatz I
SYNAPSE. 2017;71(6):UNSP e21958.

Methodological Approach for Optogenetic Manipulation of Neonatal Neuronal Networks
Bitzenhofer S, Ahlbeck J, Hanganu-Opatz I
FRONT CELL NEUROSCI. 2017;11:239.

Layer-specific optogenetic activation of pyramidal neurons causes beta-gamma entrainment of neonatal networks
Bitzenhofer S, Ahlbeck J, Wolff A, Wiegert J, Gee C, Oertner T, Hanganu-Opatz I
NAT COMMUN. 2017;8:14563.

Neocortical Layer 6B as a Remnant of the Subplate - A Morphological Comparison
Marx M, Qi G, Hanganu-Opatz I, Kilb W, Luhmann H, Feldmeyer D
CEREB CORTEX. 2017;27(2):1011-1026.

Early-life stress impairs recognition memory and perturbs the functional maturation of prefrontal-hippocampal-perirhinal networks
Reincke S, Hanganu-Opatz I
SCI REP-UK. 2017;7:42042.

Glutamatergic deficit and schizophrenia-like negative symptoms: new evidence from ketamine-induced mismatch negativity alterations in healthy male humans
Thiebes S, Leicht G, Curic S, Steinmann S, Polomac N, Andreou C, Eichler I, Eichler L, Zöllner C, Gallinat J, Hanganu-Opatz I, Mulert C
J PSYCHIATR NEUROSCI. 2017;42(4):273-283.

Interdependent Conductances Drive Infraslow Intrinsic Rhythmogenesis in a Subset of Accessory Olfactory Bulb Projection Neurons
Gorin M, Tsitoura C, Kahan A, Watznauer K, Drose D, Arts M, Mathar R, O'Connor S, Hanganu-Opatz I, Ben-Shaul Y, Spehr M
J NEUROSCI. 2016;36(11):3127-44.

Thalamic and Entorhinal Network Activity Differently Modulates the Functional Development of Prefrontal-Hippocampal Interactions
Hartung H, Brockmann M, Pöschel B, De Feo V, Hanganu-Opatz I
J NEUROSCI. 2016;36(13):3676-90.

From Shortage to Surge: A Developmental Switch in Hippocampal-Prefrontal Coupling in a Gene-Environment Model of Neuropsychiatric Disorders
Hartung H, Cichon N, De Feo V, Riemann S, Schildt S, Lindemann C, Mulert C, Gogos J, Hanganu-Opatz I
CEREB CORTEX. 2016;26(11):4265-4281.

Spindle Activity Orchestrates Plasticity during Development and Sleep
Lindemann C, Ahlbeck J, Bitzenhofer S, Hanganu-Opatz I
NEURAL PLAST. 2016;5787423.

Balancing family with a successful career in neuroscience
Poirazi P, Belin D, Gräff J, Hanganu-Opatz I, López-Bendito G
EUR J NEUROSCI. 2016;44(2):1797-803.

The road to independence. How to get funding in neuroscience
Yaksi E, Poirazi P, Hanganu-Opatz I
EUR J NEUROSCI. 2016;43(5):603-7.

Resting-state theta-band connectivity and verbal memory in schizophrenia and in the high-risk state
Andreou C, Leicht G, Nolte G, Polomac N, Moritz S, Karow A, Hanganu-Opatz I, Engel A, Mulert C
SCHIZOPHR RES. 2015;161(2-3):299-307.

Increased Resting-State Gamma-Band Connectivity in First-Episode Schizophrenia
Andreou C, Nolte G, Leicht G, Polomac N, Hanganu-Opatz I, Lambert M, Engel A, Mulert C
SCHIZOPHRENIA BULL. 2015;41(4):930-939.

Oscillatory activity in developing prefrontal networks results from theta-gamma-modulated synaptic inputs.
Bitzenhofer S, Sieben K, Spehr M, Hanganu-Opatz I
CELL REP. 2015;11(3):486-497.

Neonatal hypoxia-ischemia impairs juvenile recognition memory by disrupting the maturation of prefrontal-hippocampal networks
Domnick N, Gretenkord S, De Feo V, Sedlacik J, Brockmann M, Hanganu-Opatz I
EXP NEUROL. 2015;273:202-14.

Introduction to the Special Issue on Multisensory Development and Plasticity
Gori M, Hanganu-Opatz I
MULTISENS RES. 2015;28(1-2):31-32.

You are not alone: selecting your group members and leading an outstanding research team
Hanganu-Opatz I, Mameli M, Káradóttir R, Spires-Jones T
EUR J NEUROSCI. 2015;42(12):3012-7.

Unraveling Cross-Modal Development in Animals: Neural Substrate, Functional Coding and Behavioral Readout
Hanganu-Opatz I, Rowland B, Bieler M, Sieben K
MULTISENS RES. 2015;28(1-2):33-69.

Event-related potential evidence for a dynamic (re-)weighting of somatotopic and external coordinates of touch during visual-tactile interactions
Ley P, Steinberg U, Hanganu-Opatz I, Röder B
EUR J NEUROSCI. 2015;41(11):1466-74.

Treatment during a vulnerable developmental period rescues a genetic epilepsy
Marguet S, Le-Schulte V, Merseburg A, Neu A, Eichler R, Jakovcevski I, Ivanov A, Hanganu-Opatz I, Bernard C, Morellini F, Isbrandt D
NAT MED. 2015;21(12):1436-44.

Neonatal Restriction of Tactile Inputs Leads to Long-Lasting Impairments of Cross-Modal Processing
Sieben K, Bieler M, Röder B, Hanganu-Opatz I
PLOS BIOL. 2015;13(11):Art. e1002304.

Resting-state connectivity in the prodromal phase of schizophrenia: insights from EEG microstates
Andreou C, Faber P, Leicht G, Schoettle D, Polomac N, Hanganu-Opatz I, Lehmann D, Mulert C
SCHIZOPHR RES. 2014;152(2-3):513-20.

Oscillatory coupling within neonatal prefrontal-hippocampal networks is independent of selective removal of GABAergic neurons in the hippocampus
Bitzenhofer S, Hanganu-Opatz I
NEUROPHARMACOLOGY. 2014;77:57-67.

Activation of glycine receptors modulates spontaneous epileptiform activity in the immature rat hippocampus
Chen R, Okabe A, Sun H, Sharopov S, Hanganu-Opatz I, Kolbaev S, Fukuda A, Luhmann H, Kilb W
J PHYSIOL-LONDON. 2014;592(Pt 10):2153-68.

Unsupervised classification of neocortical activity patterns in neonatal and pre-juvenile rodents
Cichon N, Denker M, Grün S, Hanganu-Opatz I
FRONT NEURAL CIRCUIT. 2014;8:50.

Hypoxia-ischemia disrupts directed interactions within neonatal prefrontal-hippocampal networks
Brockmann M, Kukovic M, Schönfeld M, Sedlacik J, Hanganu-Opatz I
PLOS ONE. 2013;8(12):e83074.

Neonatal cholinergic lesion alters the acoustic structure of infant rat vocalization but not the early cognitive development.
Krüger H, Hanganu-Opatz I
DEV PSYCHOBIOL. 2013;55(3):294-308.

Oscillatory entrainment of primary somatosensory cortex encodes visual control of tactile processing.
Sieben K, Röder B, Hanganu-Opatz I
J NEUROSCI. 2013;33(13):5736-5749.

Cholinergic control in developing prefrontal-hippocampal networks.
Janiesch P, Krüger H, Pöschel B, Hanganu-Opatz I
J NEUROSCI. 2012;31(49):17955-17970.

Neonatal hippocampal lesion alters the functional maturation of the prefrontal cortex and the early cognitive development in pre-juvenile rats.
Krüger H, Brockmann M, Salamon J, Ittrich H, Hanganu-Opatz I
NEUROBIOL LEARN MEM. 2012;97(4):470-481.

Coupled oscillations mediate directed interactions between prefrontal cortex and hippocampus of the neonatal rat.
Brockmann M, Pöschel B, Cichon N, Hanganu-Opatz I
NEURON. 2011;71(2):332-347.

Between molecules and experience: role of early patterns of coordinated activity for the development of cortical maps and sensory abilities.
Hanganu-Opatz I, Ileana L
BRAIN RES REV. 2010;64(1):160-176.

Subplate cells: amplifiers of neuronal activity in the developing cerebral cortex.
Luhmann H, Kilb W, Hanganu-Opatz I
FRONT NEUROANAT. 2009;3:19.

Three patterns of oscillatory activity differentially synchronize developing neocortical networks in vivo.
Yang J, Hanganu-Opatz I, Sun J, Luhmann H
J NEUROSCI. 2009;29(28):9011-9025.

Letzte Aktualisierung aus dem FIS: 01.08.2025 - 00:32 Uhr