Publikationen im Institut für Biochemie und Signaltransduktion

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Epidemiology of invasive aspergillosis and azole resistance in patients with acute leukaemia:the SEPIA Study
Koehler P, Hamprecht A, Bader O, Bekeredjian-Ding I, Buchheidt D, Doelken G, Elias J, Haase G, Hahn-Ast C, Karthaus M, Kekulé A, Keller P, Kiehl M, Krause S, Krämer C, Neumann S, Rohde H, La Rosée P, Ruhnke M, Schafhausen P, Schalk E, Schulz K, Schwartz S, Silling G, Staib P, Ullmann A, Vergoulidou M, Weber T, Cornely O, Vehreschild M
INT J ANTIMICROB AG. 2017;49(2):218-223.

Runx1 downregulates stem cell and megakaryocytic transcription programs that support niche interactions.
Behrens K, Triviai I, Schwieger M, Nilgun T, Alawi M, Spohn M, Indenbirken D, Ziegler M, Müller U, WS A, Stocking C
BLOOD. 2016;127(26):3369-81.

Outcome and features of acute kidney injury complicating hypoxic hepatitis at the medical intensive care unit
Drolz A, Horvatits T, Roedl K, Rutter K, Staufer K, Haider D, Zauner C, Heinz G, Schellongowski P, Kluge S, Trauner M, Fuhrmann V
ANN INTENSIVE CARE. 2016;6(1):61.

Control of aromatase in hippocampal neurons
Fester L, Brandt N, Windhorst S, Pröls F, Bläute C, Rune G
J STEROID BIOCHEM. 2016;160:9-14.

Downregulation of AKT3 Increases Migration and Metastasis in Triple Negative Breast Cancer Cells by Upregulating S100A4
Grottke A, Ewald F, Lange T, Nörz D, Herzberger C, Bach J, Grabinski N, Gräser L, Höppner F, Nashan B, Schumacher U, Jücker M
PLOS ONE. 2016;11(1):e0146370.

AllergoOncology - the impact of allergy in oncology
Jensen-Jarolim E, Bax H, Bianchini R, Capron M, Corrigan C, Castells M, Dombrowicz D, Daniels-Wells T, Fazekas J, Fiebiger E, Gatault S, Gould H, Janda J, Josephs D, Karagiannis P, Levi-Schaffer F, Meshcheryakova A, Mechtcheriakova D, Mekori Y, Mungenast F, Nigro E, Penichet M, Redegeld F, Saul L, Singer J, Spicer J, Siccardi A, Spillner E, Turner M, Untersmayr E, Vangelista L, Karagiannis S
ALLERGY. 2016 [Epub ahead of print].

Inositol-1,4,5-trisphosphate-3-kinase-A controls morphology of hippocampal dendritic spines
Köster J, Leggewie B, Blechner C, Brandt N, Fester L, Rune G, Schweizer M, Kindler S, Windhorst S
CELL SIGNAL. 2016;28(1):83-90.

Human serum substitution by artificial sera of scalable allergen reactivity based on polyclonal antibodies and chimeras of human FcγRI and IgE domains
Offermann N, Plum M, Hübner U, Rathloff K, Braren I, Fooke M, Spillner E
ALLERGY. 2016;71(12):1794-1799.

The catalytic domain of inositol-1,4,5-trisphosphate 3-kinase-a contributes to ITPKA-induced modulation of F-actin
Ashour D, Pelka B, Jaaks P, Wundenberg T, Blechner C, Zobiak B, Failla A, Windhorst S
Cytoskeleton (Hoboken). 2015;72(2):93-100.

The tumor suppressor SHIP1 colocalizes in nucleolar cavities with p53 and components of PML nuclear bodies
Ehm P, Nalaskowski M, Wundenberg T, Jücker M
Nucleus. 2015;6(2):154-64.

Vertical Targeting of AKT and mTOR as Well as Dual Targeting of AKT and MEK Signaling Is Synergistic in Hepatocellular Carcinoma
Ewald F, Nörz D, Grottke A, Bach J, Herzberger C, Hofmann B, Nashan B, Jücker M
J CANCER. 2015;6(12):1195-205.

COSMC knockdown mediated aberrant O-glycosylation promotes oncogenic properties in pancreatic cancer
Hofmann B, Schlüter L, Lange P, Mercanoglu B, Ewald F, Fölster A, Picksak A, Harder S, El Gammal A, Grupp K, Güngör C, Drenckhan A, Schlüter H, Wagener C, Izbicki J, Jücker M, Bockhorn M, Wolters-Eisfeld G
MOL CANCER. 2015;14(1):109.

ErbB2 signaling activates the Hedgehog pathway via PI3K-Akt in human esophageal adenocarcinoma: Identification of novel targets for concerted therapy concepts
Kebenko M, Drenckhan A, Gros S, Jücker M, Grabinski N, Ewald F, Grottke A, Schultze A, Izbicki J, Bokemeyer C, Wellbrock J, Fiedler W
CELL SIGNAL. 2015;27(2):373-81.

Drosophila homologue of Diaphanous 1 (DIAPH1) controls the metastatic potential of colon cancer cells by regulating microtubule-dependent adhesion
Lin Y, Bhuwania R, Gromova K, Failla A, Lange T, Riecken K, Linder S, Kneussel M, Izbicki J, Windhorst S
ONCOTARGET. 2015;6(21):18577-89.

Ex vivo aorta patch model for analysis of cellular adhesion
Lin Y, Thata R, Failla A, Geissen M, Daum G, Windhorst S
TISSUE CELL. 2015;47(3):266-72.

Discontinuing MEK inhibitors in tumor cells with an acquired resistance increases migration and invasion
Nörz D, Grottke A, Bach J, Herzberger C, Hofmann B, Nashan B, Jücker M, Ewald F
CELL SIGNAL. 2015;27(11):2191-200.

The new InsP3Kinase inhibitor BIP-4 is competitive to InsP3 and blocks proliferation and adhesion of lung cancer cells
Schröder D, Tödter K, Gonzalez B, Franco-Echevarría E, Rohaly G, Blechner C, Lin H, Mayr G, Windhorst S
BIOCHEM PHARMACOL. 2015;96(2):143-50.

Venomics of the Australian eastern brown snake (Pseudonaja textilis): Detection of new venom proteins and splicing variants
Viala V, Hildebrand D, Trusch M, Fucase T, Sciani J, Pimenta D, Arni R, Schlüter H, Betzel C, Mirtschin P, Dunstan N, Spencer P
TOXICON. 2015;107(Pt B):252-65.

Proteomic analysis of the rare Uracoan rattlesnake Crotalus vegrandis venom
Viala V, Hildebrand D, Fucase T, Sciani J, Prezotto-Neto J, Riedner M, Sanches L, Nishimura P, Oguiura N, Pimenta D, Schlüter H, Betzel C, Arni R, Spencer P
TOXICON. 2015;107(Pt B):234-51.

Expression of Hedgehog Pathway Mediator GLI Represents a Negative Prognostic Marker in Human Acute Myeloid Leukemia and Its Inhibition Exerts Antileukemic Effects
Wellbrock J, Latuske E, Köhler J, Wagner K, Stamm H, Vettorazzi E, Vohwinkel G, Klokow M, Uibeleisen R, Ehm P, Riecken K, Loges S, Thol F, Schubert C, Amling M, Jücker M, Bokemeyer C, Heuser M, Krauter J, Fiedler W
CLIN CANCER RES. 2015.

Suppression of early hematogenous dissemination of human breast cancer cells to bone marrow by retinoic acid induced 2
Werner S, Brors B, Eick J, Marques E, Pogenberg V, Parret A, Kemming D, Wood A, Edgren H, Neubauer H, Streichert T, Riethdorf S, Bedi U, Baccelli I, Jücker M, Eils R, Fehm T, Trumpp A, Johnsen S, Klefstrom J, Wilmanns M, Müller V, Pantel K, Wikman-Kocher H
CANCER DISCOV. 2015;5(5):506-19.

"Alkohol und Nikotin"-Konzept und Evaluation eines interdisziplinären Wahlfachs mit OSPE im Studienabschnitt Medizin 1
Bergelt C, Lauke-Wettwer H, Petersen-Ewert C, Jücker M, Bauer C
GMS Z Med Ausbild. 2014;31(1):1-20.

H2S preconditioning of human adipose tissue-derived stem cells increases their efficacy in an in vitro model of cell therapy for simulated ischemia
Dongó E, Benkő Z, Csizmazia Á, Marosi G, Grottke A, Jücker M, Schumacher U, Kiss L
LIFE SCI. 2014;113(1-2):14-21.

Dual Inhibition of PI3K-AKT-mTOR- and RAF-MEK-ERK-signaling is synergistic in cholangiocarcinoma and reverses acquired resistance to MEK-inhibitors
Ewald F, Nörz D, Grottke A, Hofmann B, Nashan B, Jücker M
INVEST NEW DRUG. 2014;32(6):1144-54.

AKT3 regulates ErbB2, ErbB3 and estrogen receptor α expression and contributes to endocrine therapy resistance of ErbB2(+) breast tumor cells from Balb-neuT mice
Grabinski N, Möllmann K, Milde-Langosch K, Müller V, Schumacher U, Brandt B, Pantel K, Jücker M
CELL SIGNAL. 2014;26(5):1021-9.

Ibrutinib (ImbruvicaTM) potently inhibits ErbB receptor phosphorylation and cell viability of ErbB2-positive breast cancer cells
Grabinski N, Ewald F
INVEST NEW DRUG. 2014;32(6):1096-1104.

Efficacious inhibition of Importin α/β-mediated nuclear import of human inositol phosphate multikinase
Kublun I, Ehm P, Brehm M, Nalaskowski M
BIOCHIMIE. 2014;102:117-23.

Expression of DIAPH1 is up-regulated in colorectal cancer and its down-regulation strongly reduces the metastatic capacity of colon carcinoma cells
Lin Y, Izbicki J, König A, Habermann J, Blechner C, Lange T, Schumacher U, Windhorst S
INT J CANCER. 2014;134(7):1571-82.

Expression, Purification and preliminary X-Ray diffraction of a pathogenic bacterial protease from Stenotrophomonas maltophilia
Negm A, Windhorst S, Betzel C, Akrem A, Weber W
World J Pharm Pharm Sci. 2014;3(10):13-23.

Cellular internalisation of an inositol phosphate visualised by using fluorescent InsP5
Riley A, Windhorst S, Lin H, Potter B
CHEMBIOCHEM. 2014;15(1):57-67.

Discovery of InsP6-kinases as InsP6 dephosphorylating enzymes provides a new mechanism of cytosolic InsP6 degradation driven by the cellular ATP/ADP ratio
Wundenberg T, Grabinski N, Lin H, Mayr G
BIOCHEM J. 2014.

A non-catalytic role for inositol 1,3,4,5,6-pentakisphosphate 2-kinase in the synthesis of ribosomal RNA
Brehm M, Wundenberg T, Williams J, Mayr G, Shears S
J CELL SCI. 2013;126(Pt 2):437-44.

Expression Regulation of the Metastasis-Promoting Protein InsP3-Kinase-A in Tumor Cells.
Chang L, Schwarzenbach H, Meyer-Staeckling S, Brandt B, Mayr G, Weitzel J, Windhorst S
MOL CANCER RES. 2013.

Combined targeting of AKT and mTOR using MK-2206 and RAD001 is synergistic in the treatment of cholangiocarcinoma
Ewald F, Grabinski N, Grottke A, Windhorst S, Nörz D, Carstensen L, Staufer K, Hofmann B, Diehl F, David K, Schumacher U, Nashan B, Jücker M
INT J CANCER. 2013;133(9):2065-76.

Malignant H1299 tumour cells preferentially internalize iron-bound inositol hexakisphosphate
Helmis C, Blechner C, Lin H, Schweizer M, Mayr G, Nielsen P, Windhorst S
BIOSCIENCE REP . 2013;33(5):.

Structure-activity relationship of adenosine 5'-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel: rational design of antagonists
Moreau C, Kirchberger T, Swarbrick J, Bartlett S, Fliegert R, Yorgan T, Bauche A, Harneit A, Guse A, Potter B
J MED CHEM. 2013;56(24):10079-102.

Dissection of cell cycle-dependent dynamics of Dnmt1 by FRAP and diffusion-coupled modeling
Schneider K, Fuchs C, Dobay A, Rottach A, Qin W, Wolf P, Álvarez-Castro J, Nalaskowski M, Kremmer E, Schmid V, Leonhardt H, Schermelleh L
NUCLEIC ACIDS RES. 2013;41(9):4860-76.

Identification of a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A
Schröder D, Rehbach C, Seyffarth C, Neuenschwander M, Kries J, Windhorst S
BIOCHEM BIOPH RES CO. 2013;439(2):228-34.

Tumour cells can employ extracellular Ins(1,2,3,4,5,6)P(6) and multiple inositol-polyphosphate phosphatase 1 (MINPP1) dephosphorylation to improve their proliferation
Windhorst S, Lin H, Blechner C, Fanick W, Brandt L, Brehm M, Mayr G
BIOCHEM J. 2013;450(1):115-25.

Functional characterization and immune recognition of the extracellular superoxide dismutase from the human pathogenic parasite Onchocerca volvulus (OvEC-SOD).
Ajonina-Ekoti I, Ndjonka D, Tanyi M, Wilbertz M, Younis A, Boursou D, Kurosinski M, Eberle R, Lüersen K, Perbandt M, Breloer M, Brattig N, Liebau E
ACTA TROP. 2012;124(1):15-26.

Leukemia-associated mutations in SHIP1 inhibit its enzymatic activity, interaction with the GM-CSF receptor and Grb2, and its ability to inactivate PI3K/AKT signaling.
Brauer H, Strauss J, Wegner W, Müller-Tidow C, Horstmann M, Jücker M
CELL SIGNAL. 2012;24(11):2095-2101.

Structure of the recombinant BPTI/Kunitz-type inhibitor rShPI-1A from the marine invertebrate Stichodactyla helianthus.
García-Fernández R, Pons T, Meyer A, Perbandt M, González-González Y, Gil D, de Los Angeles Chávez M, Betzel C, Redecke L
ACTA CRYSTALLOGR F. 2012;68(Pt 11):1289-1293.

Structural insights into serine protease inhibition by a marine invertebrate BPTI Kunitz-type inhibitor.
García-Fernández R, Pons T, Perbandt M, Valiente P, Talavera A, González-González Y, Rehders D, Chávez M, Betzel C, Redecke L
J STRUCT BIOL. 2012;180(2):271-279.

Combined targeting of AKT and mTOR synergistically inhibits proliferation of hepatocellular carcinoma cells.
Grabinski N, Ewald F, Hofmann B, Staufer K, Schumacher U, Nashan B, Jücker M
MOL CANCER. 2012;11:85.

Linking NAADP to ion channel activity: a unifying hypothesis.
Guse A, Andreas H
SCI SIGNAL. 2012;5(221):18.

Activation of PI3K/Akt signaling by n-terminal SH2 domain mutants of the p85α regulatory subunit of PI3K is enhanced by deletion of its c-terminal SH2 domain.
Hofmann B, Jücker M
CELL SIGNAL. 2012;24(10):1950-1954.

A novel Entamoeba histolytica inositol phosphate kinase catalyzes the formation of 5PP-Ins(1,2,3,4,6)P(5)
Löser B, Nalaskowski M, Fanick W, Lin H, Tannich E, Mayr G
MOL BIOCHEM PARASIT. 2012;181(1):49-52.

Nucleocytoplasmic shuttling of human inositol phosphate multikinase is influenced by CK2 phosphorylation.
Meyer R, Nalaskowski M, Ehm P, Schröder C, Naj X, Brehm M, Mayr G
BIOL CHEM. 2012;393(3):149-160.

Aberrant cyclization affords a C-6 modified cyclic adenosine 5'-diphosphoribose analogue with biological activity in Jurkat T cells.
Moreau C, Kirchberger T, Zhang B, Thomas M, Weber K, Guse A, Potter B
J MED CHEM. 2012;55(4):1478-1489.

A toolkit for graded expression of green fluorescent protein fusion proteins in mammalian cells.
Nalaskowski M, Ehm P, Giehler S, Mayr G
ANAL BIOCHEM. 2012;428(1):24-27.

The inositol 5-phosphatase SHIP1 is a nucleo-cytoplasmic shuttling protein and enzymatically active in cell nuclei.
Nalaskowski M, Metzner A, Brehm M, Labiadh S, Brauer H, Grabinski N, Mayr G, Jücker M
CELL SIGNAL. 2012;24(3):621-628.

Nicotinic acid adenine dinucleotide phosphate (NAADP) degradation by alkaline phosphatase.
Schmid F, Fliegert R, Westphal T, Bauche A, Guse A
J BIOL CHEM. 2012;287(39):32525-32534.

Alternative splicing of the N-terminal cytosolic and transmembrane domains of P2X7 controls gating of the ion channel by ADP-ribosylation.
Schwarz N, Drouot L, Nicke A, Fliegert R, Boyer O, Guse A, Haag F, Adriouch S, Koch-Nolte F
PLOS ONE. 2012;7(7):41269.

A Plasmodium multi-domain protein possesses multiple inositol phosphate kinase activities.
Stritzke C, Nalaskowski M, Fanick W, Lin H, Mayr G
MOL BIOCHEM PARASIT. 2012;186(2):134-138.

Nicotinic Acid Adenine Dinucleotide 2-Phosphate (NAADP) Binding Proteins in T-Lymphocytes
Walseth T, Lin-Moshier Y, Weber K, Marchant J, Slama J, Guse A
Messenger. 2012;1(1):86-94.

Anti-tumor activity of a B-cell receptor-targeted peptide in a novel disseminated lymphoma xenograft model.
Wehr C, Müller F, Schüler J, Tomann T, Nitschke C, Seismann H, Spillner E, Klingner K, Schneider-Merck T, Binder M, Fiebig H, Mertelsmann R, Trepel M
INT J CANCER. 2012;131(2):10-20.

Inositol-1,4,5-trisphosphate 3-kinase A regulates dendritic morphology and shapes synaptic Ca2+ transients.
Windhorst S, Minge D, Bähring R, Hüser S, Schob C, Blechner C, Lin H, Mayr G, Kindler S
CELL SIGNAL. 2012;24(3):750-757.

Synthesis and biological actions of diphosphoinositol phosphates (inositol pyrophosphates), regulators of cell homeostasis.
Wundenberg T, Mayr G
BIOL CHEM. 2012;393(9):979-998.

Distinct functional roles of Akt isoforms for proliferation, survival, migration and EGF-mediated signalling in lung cancer derived disseminated tumor cells.
Grabinski N, Bartkowiak K, Grupp K, Brandt B, Pantel K, Jücker M
CELL SIGNAL. 2011;23(12):1952-1960.

Posttranscriptional regulation of the p85α adapter subunit of phosphatidylinositol 3-kinase in human leukemia cells
Hofmann B, Hoxha E, Mohr E, Schulz K, Jücker M
LEUKEMIA LYMPHOMA. 2011;52(3):467-77.

Posttranscriptional regulation of the p85 adapter subunit of phosphatidylinositol 3-kinase in human leukemia cells.
Hofmann B, Hoxha E, Mohr E, Schulz K, Jücker M
LEUKEMIA LYMPHOMA. 2011;52(3):467-477.

Synthesis of cyclic adenosine 5'-diphosphate ribose analogues: a C2'endo/syn "southern" ribose conformation underlies activity at the sea urchin cADPR receptor.
Moreau C, Ashamu G, Bailey V, Galione A, Guse A, Potter B
ORG BIOMOL CHEM. 2011;9(1):278-290.

Venom peptide analysis of Vipera ammodytes meridionalis (Viperinae) and Bothrops jararacussu (Crotalinae) demonstrates subfamily-specificity of the peptidome in the family Viperidae.
Munawar A, Trusch M, Georgieva D, Spencer P, Frochaux V, Harder S, Arni R, Duhalov D, Genov N, Schlüter H, Betzel C
Mol Biosyst. 2011;7(12):3298-3307.

Human inositol 1,4,5-trisphosphate 3-kinase isoform B (IP3KB) is a nucleocytoplasmic shuttling protein specifically enriched at cortical actin filaments and at invaginations of the nuclear envelope.
Nalaskowski M, Fliegert R, Ernst O, Brehm M, Fanick W, Windhorst S, Lin H, Giehler S, Hein J, Lin Y, Mayr G
J BIOL CHEM. 2011;286(6):4500-4510.

A novel membrane-permeant cADPR antagonist modified in the pyrophosphate bridge.
Qi N, Jung K, Wang M, Na L, Yang Z, Zhang L, Guse A, Zhang L
CHEM COMMUN. 2011;47(33):9462-9464.

CD38: a NAADP degrading enzyme.
Schmid F, Bruhn S, Weber K, Mittrücker H, Guse A
FEBS LETT. 2011;585(22):3544-3548.

Human regulatory T cells rapidly suppress T cell receptor-induced Ca(2+), NF-κB, and NFAT signaling in conventional T cells.
Schmidt A, Oberle N, Weiss E, Vobis D, Frischbutter S, Baumgrass R, Falk C, Haag M, Brügger B, Lin H, Mayr G, Reichardt P, Gunzer M, Suri-Payer E, Krammer P
SCI SIGNAL. 2011;4(204):90.

Risk of recurrence and survival after relapse in patients with Ewing sarcoma.
Stahl M, Ranft A, Paulussen M, Bölling T, Vieth V, Bielack S, Görtitz I, Braun-Munzinger G, Hardes J, Jürgens H, Dirksen U
PEDIATR BLOOD CANCER. 2011;57(4):549-553.

Functional role of inositol-1,4,5-trisphosphate-3-kinase-A for motility of malignant transformed cells.
Windhorst S, Kalinina T, Schmid K, Blechner C, Kriebitzsch N, Hinsch R, Chang L, Herich L, Schumacher U, Mayr G
INT J CANCER. 2011;129(6):1300-1309.

CHL1 is a selective organizer of the presynaptic machinery chaperoning the SNARE complex.
Andreyeva A, Leshchyns´ka I, Knepper M, Betzel C, Redecke L, Sytnyk V, Schachner M
PLOS ONE. 2010;5(8):12018.

Diadenosine homodinucleotide products of ADP-ribosyl cyclases behave as modulators of the purinergic receptor P2X7.
Bruzzone S, Basile G, Chothi M, Nobbio L, Usai C, Jacchetti E, Schenone A, Guse A, Francesco D, Antonio D, Zocchi E
J BIOL CHEM. 2010;285(27):21165-21174.

Nicotinic acid adenine dinucleotide phosphate-mediated calcium signalling in effector T cells regulates autoimmunity of the central nervous system.
Cordiglieri C, Francesca O, Zhang B, Nebel M, Kawakami N, Klinkert W, Lodygin D, Lühder F, Breunig E, Schild D, Ulaganathan V, Dornmair K, Dammermann W, Potter B, Guse A, Flügel A
BRAIN. 2010;133(7):1930-1943.

Quality control of inclusion bodies in Escherichia coli.
Jürgen B, Breitenstein A, Urlacher V, Büttner K, Lin H, Hecker M, Schweder T, Neubauer P
MICROB CELL FACT. 2010;9:41.

Novel nucleobase-simplified cyclic ADP-ribose analogue: A concise synthesis and Ca(2+)-mobilizing activity in T-lymphocytes.
Li L, Siebrands C, Yang Z, Zhang L, Guse A, Zhang L
ORG BIOMOL CHEM. 2010;8(8):1843-1848.

Synthesis and nonradioactive micro-analysis of diphosphoinositol phosphates by HPLC with postcolumn complexometry.
Lin H, Lindner K, Mayr G
Methods Mol Biol. 2010;645:103-122.

Percutaneous tissue-engineered pulmonary valved stent implantation.
Lutter G, Metzner A, Jahnke T, Bombien R, Boldt J, Iino K, Cremer J, Stock U
ANN THORAC SURG. 2010;89(1):259-263.

Percutaneous pulmonary polyurethane valved stent implantation.
Metzner A, Iino K, Steinseifer U, Uebing A, de Buhr W, Cremer J, Lutter G
J THORAC CARDIOV SUR. 2010;139(3):748-752.

Percutaneous pulmonary valve replacement: autologous tissue-engineered valved stents.
Metzner A, Stock U, Iino K, Fischer G, Huemme T, Boldt J, Braesen J, Bein B, Renner J, Cremer J, Lutter G
CARDIOVASC RES. 2010;88(3):453-461.

Functional cooperation between CREM and GCNF directs gene expression in haploid male germ cells.
Rajkovic M, Iwen K, Hofmann P, Harneit A, Weitzel J
NUCLEIC ACIDS RES. 2010;38(7):2268-2278.

Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha.
Sun M, Hillmann P, Hofmann B, Hart J, Vogt P
P NATL ACAD SCI USA. 2010;107(35):15547-15552.

Inositol-1,4,5-trisphosphate-3-kinase-A is a new cell motility-promoting protein that increases the metastatic potential of tumour cells by two functional activities.
Windhorst S, Fliegert R, Blechner C, Möllmann K, Hosseini Z, Guenther T, Eiben M, Chang L, Lin H, Fanick W, Schumacher U, Brandt B, Mayr G
J BIOL CHEM. 2010;285(8):5541-5554.

NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP antagonist.
Dammermann W, Zhang B, Nebel M, Cordiglieri C, Francesca O, Kirchberger T, Kawakami N, Dowden J, Schmid F, Dornmair K, Hohenegger M, Flügel A, Guse A, Potter B
P NATL ACAD SCI USA. 2009;106(26):10678-10683.

Second messenger signaling: multiple receptors for NAADP.
Guse A
CURR BIOL. 2009;19(13):521-523.

[Medical education in a bachelors and masters system]
Harendza S, Guse A
BUNDESGESUNDHEITSBLATT. 2009;52(9):929-932.

8-Bromo-cyclic inosine diphosphoribose: towards a selective cyclic ADP-ribose agonist.
Kirchberger T, Moreau C, Wagner G, Fliegert R, Siebrands C, Nebel M, Schmid F, Harneit A, Francesca O, Flügel A, Potter B, Guse A
BIOCHEM J. 2009.

Emerging roles of NAD+ and its metabolites in cell signaling.
Koch Nolte F, Haag F, Guse A, Lund F, Ziegler M
SCI SIGNAL. 2009;2(57):1.

Structural analysis and detection of biological inositol pyrophosphates reveals that the VIP/PPIP5K family are 1/3-kinases.
Lin H, Fridy P, Ribeiro A, Choi J, Barma D, Vogel G, Falck J, Shears S, York J, Mayr G
J BIOL CHEM. 2009;284(3):1863-1872.

Reduced proliferation of CD34(+) cells from patients with acute myeloid leukemia after gene transfer of INPP5D.
Metzner A, Precht C, Fehse B, Fiedler W, Stocking C, Günther A, Mayr G, Jücker M
GENE THER. 2009;16(4):570-573.

Einführung eines Mentorenprogramms für den Ersten Abschnitt des Studiums der Humanmedizin: Ergebnisse eines Pilotprojektes
Petersen-Ewert C, Kurré J, Scholl J, Guse A, Bullinger M
GMS Z Med Ausbild. 2009;26(3):1-6.

Phosphoinositide and inositol phosphate analysis in lymphocyte activation.
Sauer K, Huang Y, Lin H, Sandberg M, Mayr G
Curr Protoc Immunol. 2009;11:1.

Activation of the P2X7 ion channel by soluble and covalently bound ligands.
Schwarz N, Fliegert R, Adriouch S, Seman M, Guse A, Haag F, Koch Nolte F
PURINERG SIGNAL. 2009;5(2):139-149.

Prostate specific antigen: one out of five disulfide bridges determines inactivation by reduction.
Weber W, Buck F, Meyer A, Hilz H
BIOCHEM BIOPH RES CO. 2009;379(4):1101-1106.

ADP-ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site.
Adriouch S, Bannas P, Schwarz N, Fliegert R, Guse A, Seman M, Haag F, Koch Nolte F
FASEB J. 2008;22(3):861-869.

Corepressor CtBP and nuclear speckle protein Pnn/DRS differentially modulate transcription and splicing of the E-cadherin gene.
Alpatov R, Shi Y, Munguba G, Moghimi B, Joo J, Bungert J, Sugrue S
MOL CELL BIOL. 2008;28(5):1584-1595.

Assembly and structural analysis of a covalently closed nano-scale DNA cage.
Andersen F, Knudsen B, Oliveira C, Frøhlich R, Krüger D, Bungert J, Agbandje-McKenna M, McKenna R, Juul S, Veigaard C, Koch J, Rubinstein J, Guldbrandtsen B, Hede M, Karlsson G, Andersen A, Pedersen J, Knudsen B
NUCLEIC ACIDS RES. 2008;36(4):1113-1119.

Adoptive transfer of autologous, HER2-specific, cytotoxic T lymphocytes for the treatment of HER2-overexpressing breast cancer.
Bernhard H, Neudorfer J, Gebhard K, Conrad H, Hermann C, Nährig J, Fend F, Weber W, Busch D, Peschel C
CANCER IMMUNOL IMMUN. 2008;57(2):271-280.

Chronic lithium salt treatment reduces CRE/CREB-directed gene transcription and reverses its upregulation by chronic psychosocial stress in transgenic reporter gene mice.
Böer U, Cierny I, Krause D, Heinrich A, Lin H, Mayr G, Hiemke C, Knepel W
NEUROPSYCHOPHARMACOL. 2008;33(10):2407-2415.

Non-transferrin-bound iron in plasma following administration of oral iron drugs.
Dresow B, Petersen D, Fischer R, Nielsen P
BIOMETALS. 2008;21(3):273-276.

Back from the dormant stage: second messenger cyclic ADP-ribose essential for Toxoplasma gondii pathogenicity.
Guse A
SCI SIGNAL. 2008;1(17):18.

NAADP: a universal Ca2+ trigger.
Guse A, Lee H
SCI SIGNAL. 2008;1(44):10.

Mutations in the catalytic subunit of class IA PI3K confer leukemogenic potential to hematopoietic cells.
Horn S, Bergholz U, Jücker M, McCubrey J, Trümper L, Stocking C, Bäsecke J
ONCOGENE. 2008;27(29):4096-4106.

Overexpression of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase inhibits GM-CSF-dependent colony formation of CD34+ hematopoietic progenitor cells.
Hoxha E, Fehse B, Ortmeyer G, Stocking C, Mayr G, Jücker M
LEUKEMIA LYMPHOMA. 2008;49(6):1206-1208.

Ins(1,4,5)P3 3-kinase-A overexpression induces cytoskeletal reorganization via a kinase-independent mechanism.
Windhorst S, Blechner C, Lin H, Elling C, Nalaskowski M, Kirchberger T, Guse A, Mayr G
BIOCHEM J. 2008;414(3):407-417.

2'-deoxy cyclic adenosine 5'-diphosphate ribose derivatives: importance of the 2'-hydroxyl motif for the antagonistic activity of 8-substituted cADPR derivatives.
Zhang B, Wagner G, Weber K, Garnham C, Morgan A, Galione A, Guse A, Potter B
J MED CHEM. 2008;51(6):1623-1636.

Intracellular localization of human Ins(1,3,4,5,6)P5 2-kinase.
Brehm M, Schenk T, Zhou X, Fanick W, Lin H, Windhorst S, Nalaskowski M, Kobras M, Shears S, Mayr G
BIOCHEM J. 2007;408(3):335-345.

Regulation of calcium signalling by adenine-based second messengers.
Fliegert R, Gasser A, Guse A
BIOCHEM SOC T. 2007;35(1):109-114.

Modulation of Ca2+ entry and plasma membrane potential by human TRPM4b.
Fliegert R, Glassmeier G, Schmid F, Cornils K, Genisyuerek S, Harneit A, Schwarz J, Guse A
FEBS J. 2007;274(3):704-713.

Mutations at different sites in members of the Gpr1/Fun34/YaaH protein family cause hypersensitivity to acetic acid in Saccharomyces cerevisiae as well as in Yarrowia lipolytica.
Gentsch M, Kuschel M, Schlegel S, Barth G
FEMS YEAST RES. 2007;7(3):380-390.

Radiosensitization of tumour cell lines by the polyphenol Gossypol results from depressed double-strand break repair and not from enhanced apoptosis.
Kasten-Pisula U, Windhorst S, Dahm-Daphi J, Mayr G, Dikomey E
RADIOTHER ONCOL. 2007;83(3):296-303.

CD83 modulates B Cell function in vitro: increased IL-10 and reduced Ig secretion by CD83Tg B cells.
Kretschmer B, Lüthje K, Guse A, Ehrlich S, Koch Nolte F, Haag F, Fleischer B, Breloer M
PLOS ONE. 2007;2(1):755.

Gene transfer of SHIP-1 inhibits proliferation of juvenile myelomonocytic leukemia cells carrying KRAS2 or PTPN11 mutations.
Metzner A, Horstmann M, Fehse B, Ortmeyer G, Niemeyer C, Stocking C, Mayr G, Jücker M
GENE THER. 2007;14(8):699-703.

Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by adp-ribose, the major product generated by the CD38 enzyme reaction.
Partida-Sanchez S, Gasser A, Fliegert R, Siebrands C, Dammermann W, Shi G, Mousseau B, Sumoza-Toledo A, Bhagat H, Walseth T, Guse A, Lund F
J IMMUNOL. 2007;179(11):7827-7839.

Molecular interaction of droperidol with human ether-a-go-go-related gene channels: prolongation of action potential duration without inducing early afterdepolarization.
Schwoerer A, Blütner C, Brandt S, Binder S, Siebrands C, Ehmke H, Friederich P
ANESTHESIOLOGY. 2007;106(5):967-976.

Nuclear localization of enhanced green fluorescent protein homomultimers.
Seibel N, Eljouni J, Nalaskowski M, Hampe W
ANAL BIOCHEM. 2007;368(1):95-99.

Inhibition of HERG channels by the local anaesthetic articaine.
Siebrands C, Friederich P
EUR J ANAESTH. 2007;24(2):148-153.

Structural requirements of human ether-a-go-go-related gene channels for block by bupivacaine.
Siebrands C, Friederich P
ANESTHESIOLOGY. 2007;106(3):523-531.

NAADP mobilizes calcium from the endoplasmic reticular Ca(2+) store in T-lymphocytes.
Steen M, Kirchberger T, Guse A
J BIOL CHEM. 2007;282(26):18864-18871.

Methyl-CpG binding domain proteins and their involvement in the regulation of the MAGE-A1, MAGE-A2, MAGE-A3, and MAGE-A12 gene promoters.
Wischnewski F, Friese O, Pantel K, Schwarzenbach H
MOL CANCER RES. 2007;5(7):749-759.

T3-mediated gene expression is independent of PGC-1alpha
Wulf A, Harneit A, Weitzel J
MOL CELL ENDOCRINOL. 2007;270(1-2):57-63.

Detection of N-RAS and K-RAS in their active GTP-bound form in acute myeloid leukemia without activating RAS mutations.
Ehmann F, Horn S, Garcia-Palma L, Wegner W, Fiedler W, Giehl K, Mayr G, Jücker M
LEUKEMIA LYMPHOMA. 2006;47(7):1387-1391.

Cellular effects and metabolic stability of N1-cyclic inosine diphosphoribose and its derivatives.
Kirchberger T, Wagner G, Xu J, Cordiglieri C, Wang P, Gasser A, Fliegert R, Bruhn S, Flügel A, Lund F, Zhang L, Potter B, Guse A
BRIT J PHARMACOL. 2006;149(4):337-344.

Subcellular localisation of human inositol 1,4,5-trisphosphate 3-kinase C: species-specific use of alternative export sites for nucleo-cytoplasmic shuttling indicates divergent roles of the catalytic and N-terminal domains.
Nalaskowski M, Windhorst S, Stockebrand M, Mayr G
BIOL CHEM. 2006;387(5):583-593.

Synthesis and agonist activity of cyclic ADP-ribose analogues with substitution of the northern ribose by ether or alkane chains
Xu J, Yang Z, Dammermann W, Zhang L, Guse A, Zhang L
J MED CHEM. 2006;49(18):5501-12.

Prediction of response to neoadjuvant chemotherapy by sequential F-18-fluorodeoxyglucose positron emission tomography in patients with advanced-stage ovarian cancer
Avril N, Sassen S, Schmalfeldt B, Naehrig J, Rutke S, Weber W, Werner M, Graeff H, Schwaiger M, Kuhn W
J CLIN ONCOL. 2005;23(30):7445-53.

Functional ryanodine receptor expression is required for NAADP-mediated local Ca2+ signaling in T-lymphocytes
Dammermann W, Guse A
J BIOL CHEM. 2005;280(22):21394-9.

Up-regulation of the T cell quiescence factor KLF2 in a leukaemic T-cell line after expression of the inositol 5'-phosphatase SHIP-1.
García-Palma L, Horn S, Haag F, Diessenbacher P, Streichert T, Mayr G, Jücker M
BRIT J HAEMATOL. 2005;131(5):628-631.

Aha1 competes with Hop, p50 and p23 for binding to the molecular chaperone Hsp90 and contributes to kinase and hormone receptor activation.
Harst A, Lin H, Obermann Wolfgang M
BIOCHEM J. 2005;387(3):789-796.

Antiproliferative plant and synthetic polyphenolics are specific inhibitors of vertebrate inositol-1,4,5-trisphosphate 3-kinases and inositol polyphosphate multikinase.
Mayr G, Windhorst S, Hillemeier K
J BIOL CHEM. 2005;280(14):13229-13240.

Identification of the actin-binding domain of Ins(1,4,5)P3 3-kinase isoform B (IP3K-B).
Brehm M, Schreiber I, Bertsch U, Wegner A, Mayr G
BIOCHEM J. 2004;382(1):353-362.

Restoration of SHIP activity in a human leukemia cell line downregulates constitutively activated phosphatidylinositol 3-kinase/Akt/GSK-3beta signaling and leads to an increased transit time through the G1 phase of the cell cycle.
Horn S, Endl E, Fehse B, Weck M, Mayr G, Jücker M
LEUKEMIA. 2004;18(11):1839-1849.

Change of extracellular cAMP concentration is a sensitive reporter for bacterial fitness in high-cell-density cultures of Escherichia coli.
Lin H, Hoffmann F, Rozkov A, Enfors S, Rinas U, Neubauer P
BIOTECHNOL BIOENG. 2004;87(5):602-613.

An optimized fixation and extraction technique for high resolution of inositol phosphate signals in rodent brain.
Lorke D, Gustke H, Mayr G
NEUROCHEM RES. 2004;29(10):1887-1896.

The families of kinases removing the Ca2+ releasing second messenger Ins(1,4,5)P3.
Nalaskowski M, Mayr G
CURR MOL MED. 2004;4(3):277-290.

Activated G alpha q inhibits p110 alpha phosphatidylinositol 3-kinase and Akt.
Ballou L, Lin H, Fan G, Jiang Y, Lin R
J BIOL CHEM. 2003;278(26):23472-23479.

An increase in the expression and total activity of endogenous p60(c-Src) in several factor-independent mutants of a human GM-CSF-dependent leukemia cell line (TF-1)
Horn S, Meyer J, Stocking C, Ostertag W, Jücker M
ONCOGENE. 2003;22(46):7170-80.

Analysis of subcellular calcium signals in T-lymphocytes.
Kunerth S, Mayr G, Koch-Nolte F, Guse A
CELL SIGNAL. 2003;15(8):783-792.

Stimulation of the alpha1A adrenergic receptor inhibits PDGF-induced PDGF beta receptor Tyr751 phosphorylation and PI 3-kinase activation.
Lin H, Ballou L, Lin R
FEBS LETT. 2003;540(1-3):106-110.

Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone.
Lotz Gregor P, Lin H, Harst A, Obermann Wolfgang M
J BIOL CHEM. 2003;278(19):17228-17235.

Rat inositol 1,4,5-trisphosphate 3-kinase C is enzymatically specialized for basal cellular inositol trisphosphate phosphorylation and shuttles actively between nucleus and cytoplasm.
Nalaskowski M, Bertsch U, Fanick W, Stockebrand M, Schmale H, Mayr G
J BIOL CHEM. 2003;278(22):19765-19776.

Metabolic load of recombinant protein production: inhibition of cellular capacities for glucose uptake and respiration after induction of a heterologous gene in Escherichia coli.
Neubauer P, Lin H, Mathiszik B
BIOTECHNOL BIOENG. 2003;83(1):53-64.

Hierarchy of stroma-derived factors in supporting growth of stroma-dependent hemopoietic cells membrane-bound SCF is sufficient to confer stroma competence to epithelial cells
Friel J, Itoh K, Bergholz U, Jücker M, Stocking C, Harrison P, Ostertag W
Growth factors (Chur, Switzerland). 2002;20(1):35-51.

Novel hydrolysis-resistant analogues of cyclic ADP-ribose: modification of the "northern" ribose and calcium release activity.
Guse A, Cakir-Kiefer C, Fukuoka M, Shuto S, Weber K, Bailey V, Matsuda A, Mayr G, Oppenheimer N, Schuber F, Potter B
BIOCHEMISTRY-US. 2002;41(21):6744-6751.

The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization.
Nalaskowski M, Deschermeier C, Fanick W, Mayr G
BIOCHEM J. 2002;366(2):549-556.

Structure of the functional domain of the major grass-pollen allergen Phlp 5b.
Rajashankar K, Bufe A, Weber W, Eschenburg S, Lindner B, Betzel C
ACTA CRYSTALLOGR D. 2002;58(Pt 7):1175-1181.

Knock-down of the type 3 ryanodine receptor impairs sustained Ca2+ signaling via the T cell receptor/CD3 complex.
Schwarzmann N, Kunerth S, Weber K, Mayr G, Guse A
J BIOL CHEM. 2002;277(52):50636-50642.

Role of the general stress response during strong overexpression of a heterologous gene in Escherichia coli.
Schweder T, Lin H, Jürgen B, Breitenstein A, Riemschneider S, Khalameyzer V, Gupta A, Büttner K, Neubauer P
APPL MICROBIOL BIOT. 2002;58(3):330-337.

The major extracellular protease of the nosocomial pathogen Stenotrophomonas maltophilia: characterization of the protein and molecular cloning of the gene.
Windhorst S, Frank E, Georgieva D, Genov N, Buck F, Borowski P, Weber W
J BIOL CHEM. 2002;277(13):11042-11049.

Dual regulation of glycogen synthase kinase-3beta by the alpha1A-adrenergic receptor
Ballou L, Tian P, Lin H, Jiang Y, Lin R
J BIOL CHEM. 2001;276(44):40910-6.

Physiological responses to mixing in large scale bioreactors.
Enfors S, Jahic M, Rozkov A, Xu B, Hecker M, Jürgen B, Krüger E, Schweder T, Hamer G, O'Beirne D, Noisommit-Rizzi N, Reuss M, Boone L, Hewitt C, McFarlane C, Nienow A, Kovacs T, Trägårdh C, Fuchs L, Revstedt J, Friberg P, Hjertager B, Blomsten G, Skogman H, Hjort S, Hoeks F, Lin H, Neubauer P, van der Lans R, Luyben K, Vrabel P, Manelius A
J BIOTECHNOL. 2001;85(2):175-185.

Transient tyrosine phosphorylation of human ryanodine receptor upon T cell stimulation.
Guse A, Tsygankov A, Weber K, Mayr G
J BIOL CHEM. 2001;276(37):34722-34727.

Determination of the maximum specific uptake capacities for glucose and oxygen in glucose-limited fed-batch cultivations of Escherichia coli.
Lin H, Mathiszik B, Xu B, Enfors S, Neubauer P
BIOTECHNOL BIOENG. 2001;73(5):347-357.

Cellular Responses to Strong Overexpression of Recombinant Genes in Escherichia Coli
Lin H, Hanschke , Nicklisch , Riemschneider , Meyer , Gupta , Neubauer P
2001. Recombinant Protein Production with Prokaryotic and Eukaryotic Cells. A Comparative View on Host Physiology. Springer Netherlands, .

Mechanisms involved in alpha6beta1-integrin-mediated Ca(2+) signalling.
Schöttelndreier H, Potter B, Mayr G, Guse A
CELL SIGNAL. 2001;13(12):895-899.

Assay for ADP-ribosyl cyclase by reverse-phase high-performance liquid chromatography.
Schweitzer K, Mayr G, Guse A
ANAL BIOCHEM. 2001;299(2):218-226.

Inositol hexakisphosphate increases L-type Ca2+ channel activity by stimulation of adenylyl cyclase.
Yang S, Yu J, Mayr G, Hofmann F, Larsson O, Berggren P
FASEB J. 2001;15(10):1753-1763.

Tenascin-R inhibits regrowth of optic fibers in vitro and persists in the optic nerve of mice after injury
Becker T, Anliker B, Becker C, Taylor J, Schachner M, Meyer R, Bartsch U
GLIA. 2000;29(4):330-46.

Nicotinic acid adenine dinucleotide phosphate (NAADP(+)) is an essential regulator of T-lymphocyte Ca(2+)-signaling.
Berg I, Potter B, Mayr G, Guse A
J CELL BIOL. 2000;150(3):581-588.

The second messenger binding site of inositol 1,4,5-trisphosphate 3-kinase is centered in the catalytic domain and related to the inositol trisphosphate receptor site.
Bertsch U, Deschermeier C, Fanick W, Girkontaite I, Hillemeier K, Johnen H, Weglöhner W, Emmrich F, Mayr G
J BIOL CHEM. 2000;275(3):1557-1564.

Monitoring of genes that respond to overproduction of an insoluble recombinant protein in Escherichia coli glucose-limited fed-batch fermentations.
Jürgen B, Lin H, Riemschneider S, Scharf C, Neubauer P, Schmid R, Hecker M, Schweder T
BIOTECHNOL BIOENG. 2000;70(2):217-224.

Diphospho-myo-inositol phosphates during the life cycle of Dictyostelium and Polysphondylium.
Laussmann T, Pikzack C, Thiel U, Mayr G, Vogel G
EUR J BIOCHEM. 2000;267(8):2447-2451.

Influence of controlled glucose oscillations on a fed-batch process of recombinant Escherichia coli.
Lin H, Neubauer P
J BIOTECHNOL. 2000;79(1):27-37.

Stimulation of phosphatidylinositol-4-phosphate 5-kinase by Rho-kinase.
Oude Weernink P, Schulte P, Guo Y, Wetzel J, Amano M, Kaibuchi K, Haverland S, Voss M, Schmidt M, Mayr G, Jakobs K
J BIOL CHEM. 2000;275(14):10168-10174.

A novel A-isoform-like inositol 1,4,5-trisphosphate 3-kinase from chicken erythrocytes exhibits alternative splicing and conservation of intron positions between vertebrates and invertebrates.
Bertsch U, Haefs M, Möller M, Deschermeier C, Fanick W, Kitzerow A, Ozaki S, Meyer H, Mayr G
GENE. 1999;228(1-2):61-71.

Functional expression and characterisation of a new human phosphatidylinositol 4-kinase PI4K230.
Gehrmann T, Gülkan H, Suer S, Herberg F, Balla A, Vereb G, Mayr G, Heilmeyer L
BBA-BIOMEMBRANES. 1999;1437(3):341-356.

Regulation of calcium signalling in T lymphocytes by the second messenger cyclic ADP-ribose.
Guse A, Da Silva C, Berg I, Skapenko A, Weber K, Heyer P, Hohenegger M, Ashamu G, Schulze-Koops H, Potter B, Mayr G
NATURE. 1999;398(6722):70-73.

Pharmacological activation of the ryanodine receptor in Jurkat T-lymphocytes.
Hohenegger M, Berg I, Weigl L, Mayr G, Potter B, Guse A
BRIT J PHARMACOL. 1999;128(6):1235-1240.

Beta1-integrins mediate Ca2+-signalling and T cell spreading via divergent pathways.
Schöttelndreier H, Mayr G, Guse A
CELL SIGNAL. 1999;11(8):611-619.

Growth rate related concentration changes of the starvation response regulators sigmaS and ppGpp in glucose-limited fed-batch and continuous cultures of Escherichia coli.
Teich A, Meyer S, Lin H, Andersson L, Enfors S, Neubauer P
BIOTECHNOL PROGR. 1999;15(1):123-129.

Quantification of intracellular levels of cyclic ADP-ribose by high-performance liquid chromatography.
Da Silva C, Potter B, Mayr G, Guse A
J CHROMATOGR B ANALYT TECHNOL BIOMED LIFE SCI. 1998;707(1-2):43-50.

Ectocellular CD38-catalyzed synthesis and intracellular Ca2+-signalling activity of cyclic ADP-ribose in T-lymphocytes are not functionally related.
Da Silva C, Schweitzer K, Heyer P, Malavasi F, Mayr G, Guse A
FEBS LETT. 1998;439(3):291-296.

Crystallization and preliminary X-ray crystallographic analysis of the EGF receptor ectodomain.
Degenhardt M, Weber W, Eschenburg S, Dierks K, Funari S, Rapp G, Betzel C
ACTA CRYSTALLOGR D. 1998;54(Pt 5):999-1001.

Enhanced hippocampal CA1 LTP but normal spatial learning in inositol 1,4,5-trisphosphate 3-kinase(A)-deficient mice.
Jun K, Choi G, Yang S, Choi K, Kim H, Chan G, Storm D, Albert C, Mayr G, Lee C, Shin H
LEARN MEMORY. 1998;5(4-5):317-330.

Amplification of ColE1 related plasmids in recombinant cultures of Escherichia coli after IPTG induction.
Teich A, Lin H, Andersson L, Meyer S, Neubauer P
J BIOTECHNOL. 1998;64(2-3):197-210.

Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells.
Albert C, Safrany S, Bembenek M, Reddy K, Reddy K, Falck J, Bröcker M, Shears S, Mayr G
BIOCHEM J. 1997;327(2):553-560.

Vicinal thiols are involved in inositol 1,2,3,5,6-pentakisphosphate 5-phosphatase activity from fetal calf thymus.
Bandyopadhyay U, Kaiser T, Rudolf M, Schultz C, Guse A, Mayr G
BIOCHEM BIOPH RES CO. 1997;240(1):146-149.

Suppression of thyrotropin receptor-G protein-phospholipase C coupling by activation of protein kinase C in thyroid carcinoma cells.
Broecker M, Mayr G, Derwahl M
ENDOCRINOLOGY. 1997;138(9):3787-3796.

1-(5-phospho-beta-D-ribosyl)2'-phosphoadenosine 5'-phosphate cyclic anhydride induced Ca2+ release in human T-cell lines.
Guse A, Da Silva C, Weber K, Armah C, Ashamu G, Schulze C, Potter B, Mayr G, Hilz H
EUR J BIOCHEM. 1997;245(2):411-417.

Ca(2+)-signalling in human T-lymphocytes. Potential roles for cyclic ADP-ribose and 2'-phospho-cyclic ADP-ribose.
Guse A, Da Silva C, Potter B, Mayr G
ADV EXP MED BIOL. 1997;419:431-436.

Ca2+ entry induced by cyclic ADP-ribose in intact T-lymphocytes.
Guse A, Berg I, Da Silva C, Potter B, Mayr G
J BIOL CHEM. 1997;272(13):8546-8550.

Unique properties of the capacitative Ca(2+)-entry antagonist LU 52396: its inhibitory activity depends on the activation state of the cells.
Guse A, de Wit C, Klokow T, Schweitzer K, Mayr G
CELL CALCIUM. 1997;22(2):91-97.

Inhibition of phosphatases and increased Ca2+ channel activity by inositol hexakisphosphate.
Larsson O, Barker C, Sjöholm A, Carlqvist H, Michell R, Bertorello A, Nilsson T, Honkanen R, Mayr G, Zwiller J, Berggren P
SCIENCE. 1997;278(5337):471-474.

Formation of multinucleated giant cells in vitro is dependent on the stage of monocyte to macrophage maturation.
Möst J, Spötl L, Mayr G, Gasser A, Sarti A, Dierich M
BLOOD. 1997;89(2):662-671.

Integrin-mediated intracellular Ca2+ signaling in Jurkat T lymphocytes.
Weismann M, Guse A, Sorokin L, Bröker B, Frieser M, Hallmann R, Mayr G
J IMMUNOL. 1997;158(4):1618-1627.

Characterization of the C-terminal domain of ras-GTPase-activating protein (ras-GAP) as substrate for epidermal growth factor receptor and p60c-src kinase.
Borowski P, Kornetzky L, Heiland M, Roloff S, Weber W, Laufs R
Biochem Mol Biol Int. 1996;39(3):635-646.

Regulation of cADP-ribose-induced Ca2+ release by Mg2+ and inorganic phosphate.
Guse A, Silva C, Weber K, Ashamu G, Potter B, Mayr G
J BIOL CHEM. 1996;271(39):23946-23953.

Expression of the neural adhesion molecule L1 in the deafferented dentate gyrus
Jucker M, D'Amato F, Mondadori C, Mohajeri H, Magyar J, Bartsch U, Schachner M
NEUROSCIENCE. 1996;75(3):703-15.

Inositol phosphate structural requisites for Ca2+ influx.
DeLisle S, Mayr G, Welsh M
AM J PHYSIOL-HEART C. 1995;268(6 Pt 1):1485-1491.

Characterization of cyclic adenosine diphosphate-ribose-induced Ca2+ release in T lymphocyte cell lines.
Guse A, Da Silva C, Emmrich F, Ashamu G, Potter B, Mayr G
J IMMUNOL. 1995;155(7):3353-3359.

Non-radioactive, isomer-specific inositol phosphate mass determinations: high-performance liquid chromatography-micro-metal-dye detection strongly improves speed and sensitivity of analyses from cells and micro-enzyme assays.
Guse A, Goldwich A, Weber K, Mayr G
J Chromatogr B Biomed Appl. 1995;672(2):189-198.

Transient upregulation of NCAM mRNA in astrocytes in response to entorhinal cortex lesions and ischemia
Jucker M, Mondadori C, Mohajeri H, Bartsch U, Schachner M
MOL BRAIN RES. 1995;28(1):149-56.

Serine phosphorylation in the NH2 terminus of p53 facilitates transactivation.
Mayr G, Reed M, Wang P, Wang Y, Schweds J, Tegtmeyer P
CANCER RES. 1995;55(11):2410-2417.

Highly cooperative Ca2+ elevations in response to Ins(1,4,5)P3 microperfusion through a patch-clamp pipette.
Schrenzel J, Demaurex N, Foti M, Van Delden C, Jacquet J, Mayr G, Lew D, Krause K
BIOPHYS J. 1995;69(6):2378-2391.

Isolation of the myc transcription factor nucleoside diphosphate kinase and the multifunctional enzyme glyceraldehyde-3-phosphate dehydrogenase by cAMP affinity chromatography.
Weber B, Weber W, Buck F, Hilz H
INT J BIOCHEM CELL B. 1995;27(2):215-224.

Crystallization of the EGF receptor ectodomain on US space mission STS-47.
Chr B, Gunther N, Poll S, Moore K, DeLucas L, ChE B, Weber W
Microgravity Sci Technol. 1994;7(3):242-245.

Second messenger specificity of the inositol trisphosphate receptor: reappraisal based on novel inositol phosphates.
DeLisle S, Radenberg T, Wintermantel M, Tietz C, Parys J, Pittet D, Welsh M, Mayr G
AM J PHYSIOL-HEART C. 1994;266(2 Pt 1):429-436.

Role of phospholipase C in Dictyostelium: formation of inositol 1,4,5-trisphosphate and normal development in cells lacking phospholipase C activity.
Drayer [, Kaay V, Mayr G, Haastert V
EMBO J. 1994;13(7):1601-1609.

p53 oligomerization and DNA looping are linked with transcriptional activation.
Stenger J, Tegtmeyer P, Mayr G, Reed M, Wang Y, Wang P, Hough P, Mastrangelo I
EMBO J. 1994;13(24):6011-6020.

Protein microheterogeneity and crystal habits: the case of epidermal growth factor receptor isoforms as isolated in a multicompartment electrolyzer with isoelectric membranes.
Weber W, Wenisch E, Günther N, Marnitz U, Betzel C, Righetti P
J CHROMATOGR A. 1994;679(1):181-189.

Crystallization and preliminary X-ray analysis of leukemia inhibitory factor.
Betzel C, Visanji M, Dauter Z, Fourme R, Weber W, Marnitz U, Boone T, Pope J, Miller J, Hawkins N
FEBS LETT. 1993;336(2):236-238.

Calcium signalling: comparison of the role of Ca2+ influx in excitable endocrine and non-excitable myeloid cells.
Schlegel W, Mollard P, Demaurex N, Theler J, Chiavaroli C, Guérineau N, Vacher P, Mayr G, Krause K, Wollheim C
Adv Second Messenger Phosphoprotein Res. 1993;28:143-152.

The detection, purification, structural characterization, and metabolism of diphosphoinositol pentakisphosphate(s) and bisdiphosphoinositol tetrakisphosphate(s).
Stephens L, Radenberg T, Thiel U, Vogel G, Khoo K, Dell A, Jackson T, Hawkins P, Mayr G
J BIOL CHEM. 1993;268(6):4009-4015.

Regulation of Ca2+ influx in myeloid cells. Role of plasma membrane potential, inositol phosphates, cytosolic free [Ca2+], and filling state of intracellular Ca2+ stores.
Demaurex N, Schlegel W, Varnai P, Mayr G, Lew D, Krause K
J CLIN INVEST. 1992;90(3):830-839.

Metabolism of inositol phosphates in the protozoan Paramecium. Characterization of a novel inositol-hexakisphosphate-dephosphorylating enzyme.
Freund W, Mayr G, Tietz C, Schultz J
EUR J BIOCHEM. 1992;207(1):359-367.

Epigenetic activation of Gi-2 protein, the product of a putative protooncogene, mediates tumor promotion in vitro.
Harbers M, Borowski P, Fanick W, Lengyel H, Buck F, Hinsch K, Hilz H
CARCINOGENESIS. 1992;13(12):2403-2406.

A simple and rapid technique to process formalin-fixed, paraffin-embedded tissues for the detection of viruses by the polymerase chain reaction
Kiene P, Milde-Langosch K, Runkel M, Schulz K, Löning T
Virchows Arch A Pathol Anat Histopathol. 1992;420(3):269-73.

Inositol tetrakisphosphate isomers and elevation of cytosolic Ca2+ in vasopressin-stimulated insulin-secreting RINm5F cells.
Li G, Pralong W, Pittet D, Mayr G, Schlegel W, Wollheim C
J BIOL CHEM. 1992;267(7):4349-4356.

Binding of sugar phosphates, inositol phosphates and phosphorylated amino acids to actin.
Gaertner A, Mayr G, Wegner A
EUR J BIOCHEM. 1991;198(1):67-71.

Masses of inositol phosphates in resting and tetanically stimulated vertebrate skeletal muscles.
Mayr G, Thieleczek R
BIOCHEM J. 1991;280(3):631-640.

3-Aminobenzamide inhibits cytotoxicity and adhesion of phorbol-ester-stimulated granulocytes to fibroblast monolayer cultures.
Meyer T, Lengyel H, Fanick W, Hilz H
EUR J BIOCHEM. 1991;197(1):127-133.

The secreted form of the epidermal growth factor receptor. Characterization and crystallization of the receptor-ligand complex.
Günther N, Betzel C, Weber W
J BIOL CHEM. 1990;265(36):22082-22085.

Relation of phosphatidylinositol metabolism to glycolytic pathway in skeletal muscle membranes.
Heilmeyer L, Han J, Thieleczek R, Varsanyi M, Mayr G
MOL CELL BIOCHEM. 1990;99(2):111-116.

Synthesis and application of photoaffinity analogues of inositol 1,4,5-trisphosphate selectively substituted at the 1-phosphate group.
Schäfer R, Nehls-Sahabandu M, Grabowsky B, Dehlinger-Kremer M, Schulz I, Mayr G
BIOCHEM J. 1990;272(3):817-825.

Inositol 1,4-bisphosphate is an allosteric activator of muscle-type 6-phosphofructo-1-kinase.
Mayr G
BIOCHEM J. 1989;259(2):463-470.

Chemoattractant receptor promotion of Ca2+ influx across the plasma membrane of HL-60 cells. A role for cytosolic free calcium elevations and inositol 1,3,4,5-tetrakisphosphate production.
Pittet D, Lew D, Mayr G, Monod A, Schlegel W
J BIOL CHEM. 1989;264(13):7251-7261.

Mass changes in inositol tetrakis- and pentakisphosphate isomers induced by chemotactic peptide stimulation in HL-60 cells.
Pittet D, Schlegel W, Lew D, Monod A, Mayr G
J BIOL CHEM. 1989;264(31):18489-18493.

The quantitative spectrum of inositol phosphate metabolites in avian erythrocytes, analysed by proton n.m.r. and h.p.l.c. with direct isomer detection.
Radenberg T, Scholz P, Bergmann G, Mayr G
BIOCHEM J. 1989;264(2):323-333.

Inositol polyphosphate-mediated repartitioning of aldolase in skeletal muscle triads and myofibrils.
Thieleczek R, Mayr G, Brandt N
J BIOL CHEM. 1989;264(13):7349-7356.

Semisynthetic derivatives of inositol 1,4,5-trisphosphate substituted at the 1-phosphate group. Effects on calcium release from permeabilized guinea-pig parotid acinar cells and comparison with binding to aldolase A.
Henne V, Mayr G, Grabowski B, Koppitz B, Söling H
EUR J BIOCHEM. 1988;174(1):95-101.

A novel metal-dye detection system permits picomolar-range h.p.l.c. analysis of inositol polyphosphates from non-radioactively labelled cell or tissue specimens.
Mayr G
BIOCHEM J. 1988;254(2):585-591.

ADP-ribosyl proteins formed by pertussis toxin are specifically cleaved by mercury ions.
Meyer T, Koch R, Fanick W, Hilz H
Biol Chem Hoppe Seyler. 1988;369(7):579-583.

Characterization of the calmodulin-binding sites of muscle phosphofructokinase and comparison with known calmodulin-binding domains.
Buschmeier B, Meyer H, Mayr G
J BIOL CHEM. 1987;262(20):9454-9462.

Interaction of calmodulin with phosphofructokinase: binding studies and evaluation of enzymatic and physicochemical changes.
Mayr G
METHOD ENZYMOL. 1987;139:745-763.

The only inositol tetrakisphosphate detectable in avian erythrocytes is the isomer lacking phosphate at position 3: a NMR study.
Mayr G, Dietrich W
FEBS LETT. 1987;213(2):278-282.

N pi-methylhistidine in myosin-light-chain kinase.
Meyer H, Mayr G
Biol Chem Hoppe Seyler. 1987;368(12):1607-1611.

5S-rRNA-containing ribonucleoproteins from rabbit muscle and liver. Complex and partial primary structures.
Nendza R, Digweed M, Meyer H, Erdmann V, Mayr G
EUR J BIOCHEM. 1987;169(1):85-95.

2'-Phosphoadenylylation of eukaryotic proteins: a type of covalent modification.
Hilz H, Fanick W, Klapproth K
P NATL ACAD SCI USA. 1986;83(17):6267-6271.

Mammalian aldolases are isomer-selective high-affinity inositol polyphosphate binders.
Koppitz B, Vogel F, Mayr G
EUR J BIOCHEM. 1986;161(2):421-433.

Steady-state kinetics of skeletal muscle myosin light chain kinase indicate a strong down regulation by products.
Geuss U, Mayr G, Heilmeyer L
EUR J BIOCHEM. 1985;153(2):327-334.

Nonenzymic ADP-ribosylation of specific mitochondrial polypeptides.
Hilz H, Koch R, Fanick W, Klapproth K, Adamietz P
P NATL ACAD SCI USA. 1984;81(13):3929-3933.

Interaction of calmodulin with muscle phosphofructokinase. Interplay with metabolic effectors of the enzyme under physiological conditions.
Mayr G
EUR J BIOCHEM. 1984;143(3):521-529.

Interaction of calmodulin with muscle phosphofructokinase. Changes of the aggregation state, conformation and catalytic activity of the enzyme.
Mayr G
EUR J BIOCHEM. 1984;143(3):513-520.

Shape and substructure of skeletal muscle myosin light chain kinase.
Mayr G, Heilmeyer L
BIOCHEMISTRY-US. 1983;22(18):4316-4326.

Skeletal muscle myosin light chain kinase. A refined structural model.
Mayr G, Heilmeyer L
FEBS LETT. 1983;157(2):225-231.

Phosphofructokinase is a calmodulin binding protein.
Mayr G, Heilmeyer L
FEBS LETT. 1983;159(1-2):51-57.

Divergent denaturation of proteases by urea and dodecylsulfate in the absence of substrate.
Hilz H, Fanick W
Hoppe Seylers Z Physiol Chem. 1978;359(10):1447-1450.

[Steroid-cardiomyopathy: experimental generation, demonstration and quantification of its hemodynamic and contractile effects]
Strauer B, Beer K, Bürger S, Hübner G, Löhrs U, Mayr G, Meinardus A, Scherpe A
Verh Dtsch Ges Inn Med. 1978;84:679-682.

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