• 2016
  • 2016

    Ainsbury EA, Higueras M, Puig P, Einbeck J, Samaga D, Barquinero JF, Barrios L, Brzozowska B, Fattibene P, Gregoire E, Jaworska A, Lloyd D, Oestreicher U, Romm H, Rothkamm K, Roy L, Sommer S, Terzoudi G, Thierens H, Trompier F, Vral A, Woda C. Uncertainty of fast biological radiation dose assessment for emergency response scenarios. Int J Radiat Biol. 2016 Aug 30:1-37.

    Bakr A, Köcher S, Volquardsen J, Petersen C, Borgmann K, Dikomey E, Rothkamm K, Mansour WY. Impaired 53BP1/RIF1 DSB mediated end-protection stimulates CtIP-dependent end resection and switches the repair to PARP1-dependent end joining in G1. Oncotarget. 2016 Aug 2. doi: 10.18632/oncotarget.11023.

    Bakr A, Köcher S, Volquardsen J, Reimer R, Borgmann K, Dikomey E, Rothkamm K, Mansour WY. Functional crosstalk between DNA damage response proteins 53BP1 and BRCA1 regulates double strand break repair choice. Radiother Oncol 119(2):276-81. doi: 10.1016/j.radonc.2015.11.001.

    Berte N, Piee-Staffa A, Piecha N, Wang M, Borgmann K, Kaina B, Nikolova T. Targeting homologous recombination by pharmacological inhibitors enhances the killing response of glioblastoma cells treated with alkylating drugs. Mol Cancer Ther. 2016 Jul 29. pii: molcanther.0176.2016.

    Borgmann K, Köcher S, Kriegs M, Mansour WY, Parplys AC, Rieckmann T, Rothkamm K. DNA Repair. Recent Results Cancer Res 198:1-24. doi: 10.1007/978-3-662-49651-0_1.

    Braig F, Voigtlaender M, Schieferdecker A, Busch CJ, Laban S, Grob T, Kriegs M, Knecht R, Bokemeyer C, Binder M. Liquid biopsy monitoring uncovers acquired RAS-mediated resistance to cetuximab in a substantial proportion of patients with head and neck squamous cell carcinoma. Oncotarget. 2016 Apr 22. doi: 10.18632/oncotarget.8943.

    Busch CJ, Becker B, Kriegs M, Gatzemeier F, Krüger K, Möckelmann N, Fritz G, Petersen C, Knecht R, Rothkamm K, Rieckmann T. Similar cisplatin sensitivity of HPV-positive and -negative HNSCC cell lines. Oncotarget. 2016 Apr 26. doi: 10.18632/oncotarget.9028. [Epub ahead of print] PubMed PMID: 27127883.

    Bussmann L, Busch CJ, Lörincz BB, Rieckmann T, Block A, Knecht R. Perspectives in chemosensitivity and chemoresistance assays and their implementation in head and neck cancer. Eur Arch Otorhinolaryngol. 2016 Jan 11. [Epub ahead of print] PubMed PMID: 26755047.

    Dickreuter E, Eke I, Krause M, Borgmann K, van Vugt MA, Cordes N. Targeting of β1 integrins impairs DNA repair for radiosensitization of head and neck cancer cells. Oncogene 35(11):1353-62. doi: 10.1038/onc.2015.212.

    Dikomey E, Borgmann K, Kriegs M, Mansour Khalfallah W, Petersen C, Rieckmann T. DNA repair after oncological therapy (radiotherapy and chemotherapy). Oxford Textbook of Oncology. Kerr D, Haller D, van de Velde C, Baumann M (Hrsg.). Third Edition. Aufl. Oxford: Oxford University Press, 82-85.

    Dikomey E, Borgmann K, Köcher S, Kriegs M, Mansour Khalfallah W, Parplys A, Rieckmann T, Rothkamm K. Radiation DNA damage and use in cancer/therapeutics-translation of radiation modifiers. DNA Repair in Cancer Therapy. Kelley M, Fishel M (Hrsg.). 2. Aufl. London: 329 - 352.

    Eberle F, Saulich MF, Leinberger FH, Seeger W, Engenhart-Cabillic R, Dikomey E, Hänze J, Hattar K, Subtil FS. Cancer cell motility is affected through 3D cell culturing and SCF/c-Kit pathway but not by X-irradiation. Radiother Oncol 119(3):537-43. doi: 10.1016/j.radonc.2016.04.036.

    Foertsch F, Szambowska A, Weise A, Zielinski A, Schlott B, Kraft F, Mrasek K, Borgmann K, Pospiech H, Grosse F, Melle C. S100A11 plays a role in homologous recombination and genome maintenance by influencing the persistence of RAD51 in DNA repair foci. Cell Cycle. 2016 Aug 11:1-14.

    Heim D, Gil-Ibanez I, Herden J, Parplys AC, Borgmann K, Schmidt-Arras D, Lohse AW, Rose-John S, Wege H. Constitutive gp130 activation rapidly accelerates the transformation of human hepatocytes via an impaired oxidative stress response. Oncotarget. 2016 Jul 30. doi: 10.18632/oncotarget.10956.

    Higueras M, Puig P, Ainsbury EA, Vinnikov VA, Rothkamm K. A new Bayesian model applied to cytogenetic partial body irradiation estimation. Radiat Prot Dosimetry 168(3):330-6. doi: 10.1093/rpd/ncv356.

    Kari V, Mansour WY, Raul SK, Baumgart SJ, Mund A, Grade M, Sirma H, Simon R, Will H, Dobbelstein M, Dikomey E, Johnsen SA. Loss of CHD1 causes DNA repair defects and enhances prostate cancer therapeutic responsiveness. EMBO Rep. 2016 Sep 5. pii: e201642352.

    Köhler C, Koalick D, Fabricius A, Parplys AC, Borgmann K, Pospiech H, Grosse F. Cdc45 is limiting for replication initiation in humans. Cell Cycle 15(7):974-85. doi: 10.1080/15384101.2016.1152424.

    Kriegs M, Kasten-Pisula U, Riepen B, Hoffer K, Struve N, Myllynen L, Braig F, Binder M, Rieckmann T, Grénman R, Petersen C, Dikomey E, Rothkamm K. Radiosensitization of HNSCC cells by EGFR inhibition depends on the induction of cell cycle arrests. Oncotarget. 2016 May 4. doi: 10.18632/oncotarget.9161.

    Krug D, Baumann R, Rieckmann T, Fokas E, Gauer T, Niyazi M. Situation of young radiation oncologists, medical physicists and radiation biologists in German-speaking countries : Results from a web-based survey of the Young DEGRO working group. Strahlenther Onkol 192(8):507-515.

    Möckelmann N, Kriegs M, Lörincz BB, Busch CJ, Knecht R. Molecular targeting in combination with platinum-based chemoradiotherapy in head and neck cancer treatment. Head Neck 38 Suppl 1:E2173-81. doi: 10.1002/hed.24031.

    Möckelmann N, Rieckmann T, Busch CJ, Becker B, Gleißner L, Hoffer K, Omniczynski M, Steinmeister L, Laban S, Grénman R, Petersen C, Rothkamm K, Dikomey E, Knecht R, Kriegs M. Effect of sorafenib on cisplatin-based chemoradiation in head and neck cancer cells. Oncotarget 2016 Mar 22. doi: 10.18632/oncotarget.8275.

    Monteiro Gil O, Vaz P, Romm H, De Angelis C, Antunes AC, Barquinero JF, Beinke C, Bortolin E, Burbidge CI, Cucu A, Domene MM, Fattibene P, Gregoire E, Hadjidekova V, Kulka U, Lindholm C, Meschini R, M'Kacher R, Moquet J, Ostreicher U, Palitti F, Pantelias G, Della Monaca S, Montoro Pastor A, Popescu IA, Quattrini MC, Ricoul M, Rothkamm K, Sabatier L, Sebastià N, Sommer S, Terzoudi G, Testa A, Trompier F, Vral A. Capabilities of the RENEB network for research and large scale radiological and nuclear emergency situations. Int J Radiat Biol. 2016 Aug 24:1-20.

    Nuta O, Somaiah N, Boyle S, Chua ML, Gothard L, Yarnold J, Rothkamm K, Herskind C. Correlation between the radiation responses of fibroblasts cultured from individual patients and the risk of late reaction after breast radiotherapy. Cancer Lett 374(2):324-30. doi: 10.1016/j.canlet.2016.02.036.

    Oliveira M, Einbeck J, Higueras M, Ainsbury E, Puig P, Rothkamm K. Zero-inflated regression models for radiation-induced chromosome aberration data: A comparative study. Biom J. 58(2):259-79. doi: 10.1002/bimj.201400233.

    Penterling C, Drexler GA, Böhland C, Stamp R, Wilke C, Braselmann H, Caldwell RB, Reindl J, Girst S, Greubel C, Siebenwirth C, Mansour WY, Borgmann K, Dollinger G, Unger K, Friedl AA. Depletion of Histone Demethylase Jarid1A Resulting in Histone Hyperacetylation and Radiation Sensitivity Does Not Affect DNA Double-Strand Break Repair. PLoS One 11(6):e0156599. doi: 10.1371/journal.pone.0156599.

    Riedel M, Struve N, Müller-Goebel J, Köcher S, Petersen C, Dikomey E, Rothkamm K, Kriegs M. Sorafenib inhibits cell growth but fails to enhance radio- and chemosensitivity of glioblastoma cell lines. Oncotarget. 2016 Aug 17. doi: 10.18632/oncotarget.11328.

    Romm H, Ainsbury EA, Barquinero JF, Barrios L, Beinke C, Cucu A, Domene MM, Filippi S, Monteiro Gil O, Gregoire E, Hadjidekova V, Hatzi V, Lindholm C, M Kacher R, Montoro A, Moquet J, Noditi M, Oestreicher U, Palitti F, Pantelias G, Prieto MJ, Popescu I, Rothkamm K, Sebastià N, Sommer S, Terzoudi G, Testa A, Wojcik A. Web based scoring is useful for validation and harmonisation of scoring criteria within RENEB. Int J Radiat Biol. 2016 Aug 22:1-8.

    Salewsky B, Hildebrand G, Rothe S, Parplys AC, Radszewski J, Kieslich M, Wessendorf P, Krenzlin H, Borgmann K, Nussenzweig A, Sperling K, Digweed M. Directed Alternative Splicing in Nijmegen Breakage Syndrome: Proof of Principle Concerning Its Therapeutical Application. Mol Ther 24(1):117-24. doi: 10.1038/mt.2015.144.

    Somaiah N, Chua ML, Bourne S, Daley F, A' Hern R, Nuta O, Gothard L, Boyle S, Herskind C, Pearson A, Warrington J, Helyer S, Owen R, Rothkamm K, Yarnold J. Correlation between DNA damage responses of skin to a test dose of radiation and late adverse effects of earlier breast radiotherapy. Radiother Oncol. 2016 Apr 19. pii: S0167-8140(16)31046-5. doi: 10.1016/j.radonc.2016.04.012.

    Toulany M, Iida M, Keinath S, Iyi FF, Mueck K, Fehrenbacher B, Mansour WY, Schaller M, Wheeler DL, Peter Rodemann H. Dual targeting of PI3K and MEK enhances the radiation response of K-RAS mutated non-small cell lung cancer. Oncotarget. 2016 May 27. doi: 10.18632/oncotarget.9670.

    Trego KS, Groesser T, Davalos AR, Parplys AC, Zhao W, Nelson MR, Hlaing A, Shih B, Rydberg B, Pluth JM, Tsai MS, Hoeijmakers JH, Sung P, Wiese C, Campisi J, Cooper PK. Non-catalytic Roles for XPG with BRCA1 and BRCA2 in Homologous Recombination and Genome Stability. Mol Cell 61(4):535-46. doi: 10.1016/j.molcel.2015.12.026.

    Wurster S, Hennes F, Parplys AC, Seelbach JI, Mansour WY, Zielinski A, Petersen C, Clauditz TS, Münscher A, Friedl AA, Borgmann K. PARP1 inhibition radiosensitizes HNSCC cells deficient in homologous recombination by disabling the DNA replication fork elongation response. Oncotarget 7(9):9732-41. doi: 10.18632/oncotarget.6947.

  • Bakr A, Köcher S, Volquardsen J, Reimer R, Borgmann K, Dikomey E, Rothkamm K, Mansour WY. Functional crosstalk between DNA damage response proteins 53BP1 and BRCA1 regulates double strand break repair choice. Radiother Oncol. 2015 Nov 23. pii: S0167-8140(15)00592-7. doi: 10.1016/j.radonc.2015.11.001. [Epub ahead of print] PubMed PMID: 26615718.

    Bakr A, Oing C, Köcher S, Borgmann K, Dornreiter I, Petersen C, Dikomey E, Mansour WY. Involvement of ATM in homologous recombination after end resection and RAD51 nucleofilament formation. Nucleic Acids Res. 2015 Mar 31;43(6):3154-66. doi: 10.1093/nar/gkv160. Epub 2015 Mar 9. PubMed PMID: 25753674; PubMed Central PMCID: PMC4381069.

    Barnard S, Ainsbury EA, Al-hafidh J, Hadjidekova V, Hristova R, Lindholm C, Monteiro Gil O, Moquet J, Moreno M, Rößler U, Thierens H, Vandevoorde C, Vral A, Wojewódzka M, Rothkamm K. The first gamma-H2AX biodosimetry intercomparison exercise of the developing European biodosimetry network RENEB. Radiat Prot Dosimetry. 2015 Apr;164(3):265-70. doi: 10.1093/rpd/ncu259. Epub 2014 Aug 12. PubMed PMID: 25118318.

    Bouffler SD, Peters S, Gilvin P, Slack K, Markiewicz E, Quinlan RA, Gillan J, Coster M, Barnard S, Rothkamm K, Ainsbury E. The lens of the eye: exposures in the UK medical sector and mechanistic studies of radiation effects. Ann ICRP. 2015 Jun;44(1 Suppl):84-90. doi: 10.1177/0146645314560693. Epub 2015 Mar 10. PubMed PMID: 25816262.

    Braig F, März M, Schieferdecker A, Schulte A, Voigt M, Stein A, Grob T, Alawi M, Indenbirken D, Kriegs M, Engel E, Vanhoefer U, Grundhoff A, Loges S, Riecken K, Fehse B, Bokemeyer C, Binder M. Epidermal growth factor receptor mutation mediates cross-resistance to panitumumab and cetuximab in gastrointestinal cancer. Oncotarget. 2015 May 20;6(14):12035-47. PubMed PMID: 26059438; PubMed Central PMCID: PMC4494921.

    Burdak-Rothkamm S, Rothkamm K, McClelland K, Al Rashid ST, Prise KM. BRCA1, FANCD2 and Chk1 are potential molecular targets for the modulation of a radiation-induced DNA damage response in bystander cells. Cancer Lett. 2015 Jan 28;356(2 Pt B):454-61. doi: 10.1016/j.canlet.2014.09.043. Epub 2014 Oct 7. PubMed PMID: 25304378; PubMed Central PMCID: PMC4259524.

    Cook R, Zoumpoulidou G, Luczynski MT, Rieger S, Moquet J, Spanswick VJ, Hartley JA, Rothkamm K, Huang PH, Mittnacht S. Direct involvement of retinoblastoma family proteins in DNA repair by non-homologous end-joining. Cell Rep. 2015 Mar 31;10(12):2006-18. doi: 10.1016/j.celrep.2015.02.059. Epub 2015 Mar 26. PubMed PMID: 25818292; PubMed Central PMCID: PMC4386026.

    Higueras M, Puig P, Ainsbury EA, Rothkamm K. A new inverse regression model applied to radiation biodosimetry. Proc Math Phys Eng Sci. 2015 Feb 8;471(2174):20140588. PubMed PMID: 25663804; PubMed Central PMCID: PMC4309124.

    Jaworska A, Ainsbury EA, Fattibene P, Lindholm C, Oestreicher U, Rothkamm K, Romm H, Thierens H, Trompier F, Voisin P, Vral A, Woda C, Wojcik A. Operational guidance for radiation emergency response organisations in Europe for using biodosimetric tools developed in EU MULTIBIODOSE project. Radiat Prot Dosimetry. 2015 Apr;164(1-2):165-9. doi: 10.1093/rpd/ncu294. Epub 2014 Oct 1. Review. PubMed PMID: 25274532.

    Kriegs M, Gurtner K, Can Y, Brammer I, Rieckmann T, Oertel R, Wysocki M, Dorniok F, Gal A, Grob TJ, Laban S, Kasten-Pisula U, Petersen C, Baumann M, Krause M, Dikomey E. Radiosensitization of NSCLC cells by EGFR inhibition is the result of an enhanced p53-dependent G1 arrest. Radiother Oncol. 2015 Apr;115(1):120-7. doi: 10.1016/j.radonc.2015.02.018. Epub 2015 Mar 18. PubMed PMID: 25796091.

    Kulka U, Ainsbury L, Atkinson M, Barnard S, Smith R, Barquinero JF, Barrios L, Bassinet C, Beinke C, Cucu A, Darroudi F, Fattibene P, Bortolin E, Monaca SD, Gil O, Gregoire E, Hadjidekova V, Haghdoost S, Hatzi V, Hempel W, Herranz R, Jaworska A, Lindholm C, Lumniczky K, M'kacher R, Mörtl S, Montoro A, Moquet J, Moreno M, Noditi M, Ogbazghi A, Oestreicher U, Palitti F, Pantelias G, Popescu I, Prieto MJ, Roch-Lefevre S, Roessler U, Romm H, Rothkamm K, Sabatier L, Sebastià N, Sommer S, Terzoudi G, Testa A, Thierens H, Trompier F, Turai I, Vandevoorde C, Vaz P, Voisin P, Vral A, Ugletveit F, Wieser A, Woda C, Wojcik A. Realising the European network of biodosimetry: RENEB-status quo. Radiat Prot Dosimetry. 2015 Apr;164(1-2):42-5. doi: 10.1093/rpd/ncu266. Epub 2014 Sep 9. PubMed PMID: 25205835; PubMed Central PMCID: PMC4401036.

    Markiewicz E, Barnard S, Haines J, Coster M, van Geel O, Wu W, Richards S, Ainsbury E, Rothkamm K, Bouffler S, Quinlan RA. Nonlinear ionizing radiation-induced changes in eye lens cell proliferation, cyclin D1 expression and lens shape. Open Biol. 2015 Apr;5(4):150011. doi: 10.1098/rsob.150011. PubMed PMID: 25924630; PubMed Central PMCID: PMC4422125.

    Moriña D, Higueras M, Puig P, Ainsbury EA, Rothkamm K. radir package: an R implementation for cytogenetic biodosimetry dose estimation. J Radiol Prot. 2015 Sep;35(3):557-69. doi: 10.1088/0952-4746/35/3/557. Epub 2015 Jul 10. PubMed PMID: 26160852.

    Myllynen L, Kwiatkowski M, Gleißner L, Riepen B, Hoffer K, Wurlitzer M, Petersen C, Dikomey E, Rothkamm K, Schlüter H, Kriegs M. Quantitative proteomics unveiled: Regulation of DNA double strand break repair by EGFR involves PARP1. Radiother Oncol. 2015 Sep;116(3):423-30. doi: 10.1016/j.radonc.2015.09.018. Epub 2015 Sep 25. PubMed PMID: 26422459.

    Parplys AC, Seelbach JI, Becker S, Behr M, Wrona A, Jend C, Mansour WY, Joosse SA, Stuerzbecher HW, Pospiech H, Petersen C, Dikomey E, Borgmann K. High levels of RAD51 perturb DNA replication elongation and cause unscheduled origin firing due to impaired CHK1 activation. Cell Cycle. 2015;14(19):3190-202. doi: 10.1080/15384101.2015.1055996. PubMed PMID: 26317153; PubMed Central PMCID: PMC4825602.

    Parplys AC, Zhao W, Sharma N, Groesser T, Liang F, Maranon DG, Leung SG, Grundt K, Dray E, Idate R, Østvold AC, Schild D, Sung P, Wiese C. NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability. Nucleic Acids Res. 2015 Nov 16;43(20):9817-34. doi: 10.1093/nar/gkv859. Epub 2015 Aug 31. PubMed PMID: 26323318; PubMed Central PMCID: PMC4787752.

    Reuther S, Szymczak S, Raabe A, Borgmann K, Ziegler A, Petersen C, Dikomey E, Hoeller U. Association between SNPs in defined functional pathways and risk of early or late toxicity as well as individual radiosensitivity. Strahlenther Onkol. 2015 Jan;191(1):59-66. doi: 10.1007/s00066-014-0741-y. Epub 2014 Aug 26. PubMed PMID: 25156511.

    Rothkamm K, Barnard S, Moquet J, Ellender M, Rana Z, Burdak-Rothkamm S. DNA damage foci: Meaning and significance. Environ Mol Mutagen. 2015 Jul;56(6):491-504. doi: 10.1002/em.21944. Epub 2015 Mar 12. Review. PubMed PMID: 25773265.

    Smith RW, Eakins JS, Hager LG, Rothkamm K, Tanner RJ. Development of a retrospective/fortuitous accident dosimetry service based on OSL of mobile phones. Radiat Prot Dosimetry. 2015 Apr;164(1-2):89-92. doi: 10.1093/rpd/ncu370. PubMed PMID: 25841040.

    Somaiah N, Rothkamm K, Yarnold J. Where Do We Look for Markers of Radiotherapy Fraction Size Sensitivity? Clin Oncol (R Coll Radiol). 2015 Oct;27(10):570-8. doi: 10.1016/j.clon.2015.06.006. Epub 2015 Jun 21. PubMed PMID: 26108884.

    Srinivas US, Dyczkowski J, Beißbarth T, Gaedcke J, Mansour WY, Borgmann K, Dobbelstein M. 5-Fluorouracil sensitizes colorectal tumor cells towards double stranded DNA breaks by interfering with homologous recombination repair. Oncotarget. 2015 May 20;6(14):12574-86. PubMed PMID: 25909291; PubMed Central PMCID: PMC4494959.

    Struve N, Riedel M, Schulte A, Rieckmann T, Grob TJ, Gal A, Rothkamm K, Lamszus K, Petersen C, Dikomey E, Kriegs M. EGFRvIII does not affect radiosensitivity with or without gefitinib treatment in glioblastoma cells. Oncotarget. 2015 Oct 20;6(32):33867-77. doi: 10.18632/oncotarget.5293. PubMed PMID: 26418954; PubMed Central PMCID: PMC4741808.

  • Laban S, Atanackovic D, Luetkens T, Knecht R, Busch CJ, Freytag M, Spagnoli G, Ritter G, Hoffmann TK, Knuth A, Sauter G, Wilczak W, Blessmann M, Borgmann K, Muenscher A, Clauditz TS. Simultaneous cytoplasmic and nuclear protein expression of melanoma antigen-A family and NY-ESO-1 cancer-testis antigens represents an independent marker for poor survival in head and neck cancer.Int J Cancer. 2014; 135:1142-1152

    Kötter A, Cornils K, Borgmann K, Dahm-Daphi J, Petersen C, Dikomey E, Mansour WY. Inhibition of PARP1-dependent end joining contributes to olaparib-mediated radiosensitization in tumor cells. Mol Oncol 2014; 8:1616-1625.

    Reuther S, Szymczak S, Raabe A, Borgmann K, Ziegler A, Petersen C, Dikomey E, Hoeller U. Association between SNPs in defined functional pathways and risk of early or late toxicity as well as individual radiosensitivity. Strahlenther Onkol 2014; 191:59-66.

    Parplys AC, Kratz K, Speed MC, Leung SG, Schild D, Wiese C. RAD51AP1-deficiency in vertebrate cells impairs DNA replication. DNA Repair 2014; 24:87-97.

    Güster JD, Weissleder S, Busch CJ, Kriegs M, Tribius S, Knecht R, Petersen C, Dikomey E, Rieckmann. Inhibition of PARP but not EGFR results in radiosensitzation of HPV and p16-positive HNSCC cell lines. Radiother Oncol 2014; 113:345-351.

  • Mansour WY, Borgmann K, Petersen C, Dikomey E, Dahm-Daphi J. The absence of Ku but not defects in classical non-homologous end-joining is required to trigger PARP1-dependent end-joining. DNA Repair (Amst). 2013;12:1134-42.

    Baumann M, Bodis S, Dikomey E, van der Kogel A, Overgaard J, Rodemann HP, Wouters B. Molecular radiation biology/oncology at its best: Cutting edge research presented at the 13th International Wolfsberg Meeting on Molecular Radiation Biology/Oncology. Radiother Oncol. 2013;108:357-61.

    Busch CJ, Kriegs M, Laban S, Tribius S, Knecht R, Petersen C, Dikomey E, Rieckmann T. HPV-positive HNSCC cell lines but not primary human fibroblasts are radiosensitized by the inhibition of Chk1. Radiother Oncol. 2013; 108:495-9.

    Dikomey E. Predictive marker for acute normal tissue toxicity in radiotherapy of non-small cell lung cancer. Strahlenther Onkol. 2013; 189:806-8.

    Reuther S, Reiter M, Raabe A, Dikomey E. Effect of irradiation on the expression of DNA repair genes studied in human fibroblasts by real-time qPCR using three methods of reference gene validation. Radiat Environ Biophys. 2013; 52:463-9.

    Rieckmann T, Tribius S, Grob TJ, Meyer F, Busch CJ, Petersen C, Dikomey E, Kriegs M. HNSCC cell lines positive for HPV and p16 possess higher cellular radiosensitivity due to an impaired DSB repair capacity. Radiother Oncol. 2013; 107:242-6

    Saker J, Kriegs M, Zenker M, Heldt JM, Eke I, Pietzsch HJ, Grénman R, Cordes N, Petersen C, Baumann M, Steinbach J, Dikomey E, Kasten-Pisula U. Inactivation of HNSCC cells by 90Y-labeled cetuximab strictly depends on the number of induced DNA double-strand breaks. J Nucl Med. 2013; 54:416-23.

    Mansour WY, Bogdanova NV, Kasten-Pisula U, Rieckmann T, Köcher S, Borgmann K, Baumann M, Krause M, Petersen C, Hu H, Gatti RA, Dikomey E, Dörk T, Dahm-Daphi J. Aberrant overexpression of miR-421 downregulates ATM and leads to a pronounced DSB repair defect and clinical hypersensitivity in SKX squamous cell carcinoma. Radiother Oncol. 2013; 106:147-54.

    Tennstedt P, Fresow R, Simon R, Marx A, Terracciano L, Petersen C, Sauter G, Dikomey E, Borgmann K. RAD51 overexpression is a negative prognostic marker for colorectal adenocarcinoma. Int J Cancer. 2013; 132:2118-26.

    Reuther S, Metzke E, Bonin M, Petersen C, Dikomey E, Raabe A. No effect of the transforming growth factor β1 promoter polymorphism C-509T on TGFB1 gene expression, protein secretion, or cellular radiosensitivity. Int J Radiat Oncol Biol Phys. 2013; 85:460-5.

    Rieckmann T, Kriegs M, Nitsch L, Hoffer K, Rohaly G, Kocher S, Petersen C, Dikomey E, Dornreiter I, Dahm-Daphi J. p53 modulates homologous recombination at I-SceI-induced double-strand breaks through cell-cycle regulation. Oncogene. 2013; 32:968-75.

    Nikkilä J, Parplys AC, Pylkäs K, Bose M, Huo Y, Borgmann K, Rapakko K, Nieminen P, Xia B, Pospiech H, Winqvist R. Heterozygous mutations in PALB2 cause DNA replication and damage response defects. Nat Commun. 2013;4:2578.

    Laban S, Steinmeister L, Gleißner L, Grob TJ, Grénman R, Petersen C, Gal A, Knecht R, Dikomey E, Kriegs M. Sorafenib sensitizes head and neck squamous cell carcinoma cells to ionizing radiation. Radiother Oncol. 2013;109:286-92.

    Pfäffle HN, Wang M, Gheorghiu L, Ferraiolo N, Greninger P, Borgmann K, Settleman J, Benes CH, Sequist LV, Zou L, Willers H. EGFR-activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity. Cancer Res. 2013; 73:6254-63.

    Kari V, Karpiuk O, Tieg B, Kriegs M, Dikomey E, Krebber H, Begus-Nahrmann Y, Johnsen SA. A subset of histone H2B genes produces polyadenylated mRNAs under a variety of cellular conditions. PLoS One. 2013; 8:e63745.

    Kluth M, Hesse J, Heinl A, Krohn A, Steurer S, Sirma H, Simon R, Mayer PS, Schumacher U, Grupp K, Izbicki JR, Pantel K, Dikomey E, Korbel JO, Plass C, Sauter G, Schlomm T, Minner S. Genomic deletion of MAP3K7 at 6q12-22 is associated with early PSA recurrence in prostate cancer and absence of TMPRSS2:ERG fusions. Mod Pathol. 2013; 26:975-83.

    Clauditz T, Wang CJ, Gontarewicz A, Blessmann M, Tennstedt P, Borgmann K, Tribius A, Sauter G, Dalchow C, Knecht R, Münscher A, Wilczak W. Expression of insulin-like growth factor II mRNA-binding protein 3 in squamous cell carcinomas of the head and neck. Oral Pathol Med 2013; 42:125-132

    Holmström F, Pasetto A, Nähr V, Brass A, Kriegs M, Hildt E, Broderick KE, Chen M, Ahlén G, Frelin L. A synthetic codon-optimized hepatitis C virus nonstructural 5A DNA vaccine primes polyfunctional CD8+ T cell responses in wild-type and NS5A-transgenic mice. J Immunol. 2013; 190:1113-24.

  • Parplys AC, Petermann E, Petersen C, Dikomey E, Borgmann K. DNA double-strand breaks are the irradiation-induced lesions that interfere most strongly with replication forks. Radiother Oncol. 2012; 102:466-471.

    Runge R, Hiemann R, Wendisch M, Kasten-Pisula U, Storch K, Zoephel K, Fritz C, Roggenbuck D, Wunderlich G, Conrad K, Kotzerke J. Fully automated interpretation of ionizing radiation-induced γH2AX foci by the novel pattern recognition system AKLIDES®. Int J Radiat Biol. 2012; 88:439-47.

    Köcher S, Rieckmann T, Rohaly G, Mansour WY, Dikomey E, Dornreiter I, Dahm-Daphi J. Radiation-induced double-strand breaks require ATM but not Artemis for Homologous recombination during S-ohase. Nuclear Acids Res, 2012 Jun 22. [Epub ahead of print]

    Raabe A, Derda K, Reuther S, Szymczak S, Borgmann K, Hoeller U, Ziegler A, Petersen C, Dikomey E. Association of single nucleotide polymorphisms in the genes ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with risk of severe erythema after breast conserving radiotherapy. Radiother Oncol, 2012: 7:65

    Jung H, Beck-Bornholdt H-P, Svoboda V, Alberti W, Herrmann T. Late complications after radiotherapy for prostate cancer. Strahlenther Oncol, 2012; 188:965-974Dikomey E, Dahm-Daphi J, Distel L. Prädiktion von Normal- und Tumorreaktion nach Strahlentherapie. Strahlenther Onkol 2012; 188:304-307

    Dikomey E., Borgmann K., Kriegs M., Mansour W., Rieckmann T. Petersen C. Strahlenempfindlichkeit von Tumorzellen. In: Onkologie: Grundlagen, Diagnostik, Therapie, Entwicklungen (Hrsg. Zeller, zur Hausen), ecomed, München, 2012, pp1-19.

    Andreassen CN, Dikomey E, Parliament M, West CML. Will SNPs be useful predictors of normal tissue radiosensitivity in the future? Highlights from a scientific debate held at the ESTRO 31 meeting. Radiother Oncol, 105;283-288.

    Barnett GC, Elliott RM, Alsner J, Andreassen CN, Abdelhay O, Burnet NG, Chang-Claude J, Coles CE, Gutiérrez-Enríquez S, Fuentes MJ, Alonso MC, Kerns S, Raabe A, Symonds RP, Seibold P, Talbot CJ, Wenz F, Wilkinson J, Yarnold J, Dunning AM, Rosenstein B, West CML, Bentzen SM. Individual patient data meta-analysis shows no association between a SNP regulating TGF-beta 1 secretion and late radiotherapy toxicity. Radiother Oncol, 105:289-295

    Mund A, Schubert T, Staege H, Kinkley S, Reumann K, Kriegs M, Fritsch L, Battisti V, Ait-Si-Ali S, Hoffbeck AS, Soutoglou E, Will H. SPOC1 modulates DNA repair by regulating key determinants of chromatin compaction and DNA damage response. Nucleic Acids Res. 2012; 40:11363-79.

  • Zschenker O, Raabe A, Böckelmann IK, Borstelmann S, Szymczak, Wellek S, Rades D, Hoeller U, Ziegler A, Dikomey E, Borgmann K, Association of single nucleotide polymorphisms in ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with clinical and cellular radiosensitivity. Radiother Oncol 2010; 2010;97:26-32

    El-Awady RA, Saleh EM, Dahm-Daphi J, Targeting DNA double-strand break repair: is it the right way for sensitizing cells to 5-fluorouracil? Anti-Cancer Drugs 2010; 21:277-287

    Storch K, Eke I, Borgmann K, Krause M, Richter C, Becker K, Schröck E, Cordes N, Three-dimensional cell growth confers radioresistance by chromatin density. Cancer Research 2010; 2010;70:3925-3934

    Borgmann K, Raabe A, Reuther S, Szymczak S, Schlomm T, Isbarn H, Gomolka M, Busjahn A, Bonin M, Ziegler A, Dikomey E, The potential role of G2- but not of G0-radiosensitivity for predisposition of prostate cancer. Radiotherapy & Oncology 2010; 96:19-24

    Mansour WY, Rhein T, Dahm-Daphi J, The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies. Nucleic Acids Research, 2010;38:6065-6077

    Kriegs M, Kasten-Pisula, Rieckmann T, Holst K, Saker J, Dahm-Daphi J, Dikomey E, The epidermal growth factor receptor modulates DNA double-strand break repair by regulating non-homologous end-joining. DNA Repair 2010, 2010;9:889-897

    Steinberg F, Gerber SD, Rieckmann T, Trueb B. Rapid fusion and syncytium formation of heterologous cells upon expression of the FGFRL1 receptor. J Biol Chem 2010, 285:37704-37715.

    Dikomey E. Determination of DNA damage in vitro. Nuklearmedizin. 2010;49:S64-S68.

    Brassat U, Balabanov S, Bali D, Dierlamm J, Braig M, Hartmann U, Sirma H, Gunes C, Wege H, Fehse B, Gontarewicz A, Dikomey E, Borgmann K, Brummendorf TH. Functional p53 is required for effective execution of telomerase inhibition in BCR-ABL-positive CML cells. Exp Hematol 2011;39:66-76.

    Tribius S., Ihloff AS, Rieckmann T, Petersen C, Hoffmann M, Impact of HPV status on treatment of squamous cell cancer of the oropharynx: What we know and what we need to know. Cancer Letters 2011; 304:71-79.

    Kachnic LA, Li L, Fournier L, Ferraiolo N, Dahm-Daphi J, Borgmann K, Willers H. FANCD2 but not FANCA promotes cellular resistance to type II topoisomerase poisons. Cancer Letters 2011, 305:86-93.

    Meyer-Schwesinger C., Lange C., Bröcker V., Agustian PA., Lehmann U., Raabe A., Brinkmeyer M., Kobayashi E., Schiffer M.,_ Büsche G., Kreipe HH:, Thaiss F, Becker JU, Bone marrow–derived progenitor cells do not contribute to podocyte turnover in the puromycin aminoglycoside and renal ablation models in rats. Am J Pathol 2011, 178; 494-499.

    Kasten-Pisula U, Saker J, Eicheler W, Krause M, Yaromina A, Meyer-Staeckling S, Scherkl B, Kriegs M, Brandt B, Petersen C, Baumann M, Dikomey E. Cellular and tumour radiosensitivity is correlated to EGFR protein expression level in tumours without egfr amplification. Int J Radiat Oncol Biol Phys 2011, 80:1181-1188.

    Moyal L, Lerenthal Y, Gana-Weisz M, Mass G, So S, Wang SH, Eppink B, Chung YM, Shalev G, Shema E, Shkedy D, Smorodinsky N, van Vliet N, Kuster B, Mann M, Ciechanover A, Dahm-Daphi J, Kanaar R, Hu MCT, Chen DJ, Oren M, Shiloh Y, Requirement of ATM-Dependent Monoubiquitylation of Histone H2B for Timely Repair of DNA Double-Strand Breaks. Molecular Cell 2011, 41; 529-542.

    Myllynen L, Rieckmann T, Dahm-Daphi J, Kasten-Pisula U, Petersen C, Dikomey E, Kriegs M. In tumour cells regulation of DNA double strand break repair through EGF receptor involves both NHEJ and HR and is independent of p53 and K-Ras status. Radiother Oncol. 2011, 101:147-151.

    Wang M., Morsbach F., Sander D., Gheorghiu L., Nanda A., Benes C., Kriegs M., Dikomey E., Dahm-Daphi J., Settleman J., Willers H. Inhibition of the EGFR sensitizes NSCLC cells to radiation and etoposide via DNA double-strand break inducible senescence. Cancer Res, 2011; 71:6261-6269.

    Dikomey E., Borgmann K., Raabe A., Reuther S. Individuelle Strahlenempfindlichkeit: Molekulare Mechanismen der Zellinaktivierung. Ver. Strahlenschutzkommission, Band 66: 96-110.