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IL-6 trans-signaling is essential for the development of hepatocellular carcinoma in mice
Bergmann J, Müller M, Baumann N, Reichert M, Heneweer C, Bolik J, Lücke K, Gruber S, Carambia A, Boretius S, Leuschner I, Becker T, Rabe B, Herkel J, Wunderlich F, Mittrücker H, Rose-John S, Schmidt-Arras D
HEPATOLOGY. 2017;65(1):89-103.

Assessment of the HIV-1 reservoir in CD4+ regulatory T cells by a Droplet Digital PCR based approach
Dunay G, Solomatina A, Kummer S, Hüfner A, Bialek J, Eberhard J, Tolosa E, Hauber J, Wiesch J
VIRUS RES. 2017 [Epub ahead of print].

Pregnancy-Related Immune Adaptation Promotes the Emergence of Highly Virulent H1N1 Influenza Virus Strains in Allogenically Pregnant Mice
Engels G, Hierweger A, Hoffmann J, Thieme R, Thiele S, Bertram S, Dreier C, Resa-Infante P, Jacobsen H, Thiele K, Alawi M, Indenbirken D, Grundhoff A, Siebels S, Fischer N, Stojanovska V, Muzzio D, Jensen F, Karimi K, Mittrücker H, Arck P, Gabriel G
CELL HOST MICROBE. 2017;21(3):321-333.

Human leucocyte antigen (HLA-DR) gene expression is reduced in sepsis and correlates with impaired TNFα response: A diagnostic tool for immunosuppression?
Winkler M, Rissiek A, Priefler M, Schwedhelm E, Robbe L, Bauer A, Zahrte C, Zoellner C, Kluge S, Nierhaus A
PLOS ONE. 2017;12(8):e0182427.

Immunosuppressive Yersinia Effector YopM Binds DEAD Box Helicase DDX3 to Control Ribosomal S6 Kinase in the Nucleus of Host Cells
Berneking L, Schnapp M, Rumm A, Trasak C, Ruckdeschel K, Alawi M, Grundhoff A, Kikhney A, Nolte F, Buck F, Perbandt M, Betzel C, Svergun D, Hentschke M, Aepfelbacher M
PLOS PATHOG. 2016;12(6):e1005660.

The binary toxin CDT enhances Clostridium difficile virulence by suppressing protective colonic eosinophilia
Cowardin C, Buonomo E, Saleh M, Wilson M, Burgess S, Kuehne S, Schwan C, Eichhoff A, Nolte F, Lyras D, Aktories K, Minton N, Petri W
Nat Microbiol. 2016;1(8):16108.

Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation
Danquah W, Meyer-Schwesinger C, Rissiek B, Pinto C, Serracant-Prat A, Amadi M, Iacenda D, Knop J, Hammel A, Bergmann P, Schwarz N, Assunção J, Rotthier W, Haag F, Tolosa E, Bannas P, Boué-Grabot E, Magnus T, Laeremans T, Stortelers C, Nolte F
SCI TRANSL MED. 2016;8(366):366ra162.

Fetal thymus size in human pregnancies reveals inverse association with regulatory T cell frequencies in cord blood
Diemert A, Hartwig I, Pagenkemper M, Mehnert R, Hansen G, Tolosa E, Hecher K, Arck P
J REPROD IMMUNOL. 2016;113:76-82.

Parallel assessment of Th17 cell frequencies by surface marker co-expression versus ex vivo IL-17 production in HIV-1 infection
Dunay G, Tóth I, Eberhard J, Degen O, Tolosa E, Lunzen J, Hauber J, Zur Wiesch J
CYTOMETRY B CLIN CYTOM. 2016;90(6):486-492.

Liver-Resident Memory CD8(+) T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection
Fernandez-Ruiz D, Ng W, Holz L, Ma J, Zaid A, Wong Y, Lau L, Mollard V, Cozijnsen A, Collins N, Li J, Davey G, Kato Y, Devi S, Skandari R, Pauley M, Manton J, Godfrey D, Braun A, Tay S, Tan P, Bowen D, Nolte F, Rissiek B, Carbone F, Crabb B, Lahoud M, Cockburn I, Mueller S, Bertolino P, McFadden G, Caminschi I, Heath W
IMMUNITY. 2016;45(4):889-902.

Toll-Like Receptor 2 Recognizes Orientia tsutsugamushi and Increases Susceptibility to Murine Experimental Scrub Typhus
Gharaibeh M, Hagedorn M, Lilla S, Hauptmann M, Heine H, Fleischer B, Keller C
INFECT IMMUN. 2016;84(12):3379-3387.

Protective and Pathogenic Roles of CD8+ T Lymphocytes in Murine Orientia tsutsugamushi Infection
Hauptmann M, Kolbaum J, Lilla S, Wozniak D, Gharaibeh M, Fleischer B, Keller C
PLOS NEGLECT TROP D. 2016;10(9):e0004991.

Interleukin 17, Produced by γδ T Cells, Contributes to Hepatic Inflammation in a Mouse Model of Biliary Atresia and Is Increased in Livers of Patients
Klemann C, Schröder A, Dreier A, Möhn N, Dippel S, Winterberg T, Wilde A, Yu Y, Thorenz A, Gueler F, Jörns A, Tolosa E, Leonhardt J, Haas J, Prinz I, Vieten G, Petersen C, Kuebler J
GASTROENTEROLOGY. 2016;150(1):229-241.e5.

Common variable immunodeficiency, impaired neurological development and reduced numbers of T regulatory cells in a 10-year-old boy with a STAT1 gain-of-function mutation
Kobbe R, Kolster M, Fuchs S, Schulze-Sturm U, Jenderny J, Kochhan L, Staab J, Tolosa E, Grimbacher B, Meyer T
GENE. 2016;586(2):234-8.

Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney
Krebs C, Paust H, Krohn S, Koyro T, Brix S, Riedel J, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch C, Mittrücker H, Steinhoff U, Stockinger B, Perez L, Wenzel U, Janneck M, Steinmetz O, Gagliani N, Stahl R, Huber S, Turner J, Panzer U
IMMUNITY. 2016;45(5):1078-1092.

Immuno-targeting the multifunctional CD38 using nanobody
Li T, Qi S, Unger M, Hou Y, Deng Q, Liu J, Lam C, Wang X, Xin D, Zhang P, Nolte F, Hao Q, Zhang H, Lee H, Zhao Y
SCI REP-UK. 2016;6:27055.

Interferon Regulatory Factor 4 controls TH1 cell effector function and metabolism
Mahnke J, Schumacher V, Ahrens S, Käding N, Feldhoff L, Huber M, Rupp J, Raczkowski F, Mittrücker H
SCI REP-UK. 2016;6:35521.

CD4+ T Cells Are as Protective as CD8+ T Cells against Rickettsia typhi Infection by Activating Macrophage Bactericidal Activity
Moderzynski K, Papp S, Rauch J, Heine L, Kuehl S, Richardt U, Fleischer B, Osterloh A
PLOS NEGLECT TROP D. 2016;10(11):e0005089.

IL-23 prevents IL-13-dependent tissue repair associated with Ly6C(lo) monocytes in Entamoeba histolytica-induced liver damage
Noll J, Helk E, Fehling H, Bernin H, Marggraff C, Jacobs T, Huber S, Pelczar P, Ernst T, Ittrich H, Otto B, Mittrücker H, Hölscher C, Tacke F, Bruchhaus I, Tannich E, Lotter H
J HEPATOL. 2016;64(5):1147-57.

Persisting Rickettsia typhi Causes Fatal Central Nervous System Inflammation
Osterloh A, Papp S, Moderzynski K, Kuehl S, Richardt U, Fleischer B
INFECT IMMUN. 2016;84(5):1615-32.

Liver Necrosis and Lethal Systemic Inflammation in a Murine Model of Rickettsia typhi Infection: Role of Neutrophils, Macrophages and NK Cells
Papp S, Moderzynski K, Rauch J, Heine L, Kuehl S, Richardt U, Mueller H, Fleischer B, Osterloh A
PLOS NEGLECT TROP D. 2016;10(8):e0004935.

CXCR3+ Regulatory T Cells Control TH1 Responses in Crescentic GN
Paust H, Riedel J, Krebs C, Turner J, Brix S, Krohn S, Velden J, Wiech T, Kaffke A, Peters A, Bennstein S, Kapffer S, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Thaiss F, Mittrücker H, Steinmetz O, Stahl R, Panzer U
J AM SOC NEPHROL. 2016;27(7):1933-42.

Staphylococcus aureus recruits Cdc42GAP through recycling endosomes and the exocyst to invade human endothelial cells
Rauch L, Hennings K, Trasak C, Röder A, Schröder B, Nolte F, Rivera-Molina F, Toomre D, Aepfelbacher M
J CELL SCI. 2016;129(15):2937-49.

The European antibody network's practical guide to finding and validating suitable antibodies for research
Roncador G, Engel P, Maestre L, Anderson A, Cordell J, Cragg M, Šerbec V, Jones M, Lisnic V, Kremer L, Li D, Nolte F, Pascual N, Rodríguez-Barbosa J, Torensma R, Turley H, Pulford K, Banham A
MABS-AUSTIN. 2016;8(1):27-36.

A transplant “immunome” screening platform defines a targetable epitope fingerprint of multiple myeloma
Schieferdecker A, Oberle A, Thiele B, Hofmann F, Göthel M, Miethe S, Hust M, Braig F, Voigt M, Pein U, Nolte F, Haag F, Alawi M, Indenbirken D, Grundhoff A, Bokemeyer C, Bacher U, Kröger N, Binder M
BLOOD. 2016;127(25):3202-14.

Antenatal endogenous and exogenous glucocorticoids and their impact on immune ontogeny and long-term immunity
Solano M, Holmes M, Mittelstadt P, Chapman K, Tolosa E
SEMIN IMMUNOPATHOL. 2016;38(6):739-763.

IL-17 production by CSF lymphocytes as a biomarker for cerebral vasculitis
Thom V, Schmidt S, Gelderblom M, Hackbusch R, Kolster M, Schuster S, Thomalla G, Keminer O, Pleß O, Bernreuther C, Glatzel M, Wegscheider K, Gerloff C, Magnus T, Tolosa E
Neurol Neuroimmunol Neuroinflamm. 2016;3(2):e214.

Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy
Tomas N, Hoxha E, Reinicke A, Fester L, Helmchen U, Gerth J, Bachmann F, Budde K, Nolte F, Zahner G, Rune G, Lambeau G, Meyer-Schwesinger C, Stahl R
J CLIN INVEST. 2016;126(7):2519-32.

Influenza pathogenicity during pregnancy in women and animal models
van Riel D, Mittrücker H, Engels G, Klingel K, Markert U
SEMIN IMMUNOPATHOL. 2016;38(6):719-726.

Opposing role of tumor necrosis factor receptor 1 signaling in T cell-mediated hepatitis and bacterial infection in mice
Wroblewski R, Armaka M, Kondylis V, Pasparakis M, Walczak H, Mittrücker H, Schramm C, Lohse A, Kollias G, Ehlken H
HEPATOLOGY. 2016;64(2):508-521.

ADAM17 controls IL-6 signaling by cleavage of the murine IL-6Rα from the cell surface of leukocytes during inflammatory responses
Yan I, Schwarz J, Lücke K, Schumacher N, Schumacher V, Schmidt S, Rabe B, Saftig P, Donners M, Rose-John S, Mittrücker H, Chalaris A
J LEUKOCYTE BIOL. 2016;99(5):749-60.

Validation of Nanobody and Antibody Based In Vivo Tumor Xenograft NIRF-imaging Experiments in Mice Using Ex Vivo Flow Cytometry and Microscopy
Bannas P, Lenz A, Kunick V, Fumey W, Rissiek B, Schmid J, Haag F, Leingärtner A, Trepel M, Adam G, Koch-Nolte F
JOVE-J VIS EXP. 2015;(98):52462.

Molecular imaging of tumors with nanobodies and antibodies: Timing and dosage are crucial factors for improved in vivo detection
Bannas P, Lenz A, Kunick V, Well L, Fumey W, Rissiek B, Haag F, Schmid J, Schütze K, Eichhoff A, Trepel M, Adam G, Ittrich H, Koch-Nolte F
CONTRAST MEDIA MOL I. 2015;10(5):367-378.

Screening for depression in pregnant women from Côte d׳Ivoire and Ghana: Psychometric properties of the Patient Health Questionnaire-9
Barthel D, Barkmann C, Ehrhardt S, Schoppen S, Bindt C
J AFFECT DISORDERS. 2015;187:232-40.

Blockade of P2X7 receptors or pannexin-1 channels similarly attenuates postischemic damage
Cisneros-Mejorado A, Gottlieb M, Cavaliere F, Magnus T, Nolte F, Scemes E, Pérez-Samartín A, Matute C
J CEREBR BLOOD F MET. 2015;35(5):843-50.

CXCL5 drives neutrophil recruitment in TH17-mediated GN
Disteldorf E, Krebs C, Paust H, Turner J, Nouailles G, Tittel A, Meyer-Schwesinger C, Stege G, Brix S, Velden J, Wiech T, Helmchen U, Steinmetz O, Peters A, Bennstein S, Kaffke A, Llanto C, Lira S, Mittrücker H, Stahl R, Kurts C, Kaufmann S, Panzer U
J AM SOC NEPHROL. 2015;26(1):55-66.

Identification and analysis of ADP-ribosylated proteins
Haag F, Buck F
CURR TOP MICROBIOL. 2015;384:33-50.

Babies Galore; or recent findings and future perspectives of pregnancy cohorts with a focus on immunity
Hartwig I, Diemert A, Tolosa E, Hecher K, Arck P
J REPROD IMMUNOL. 2015;108:6-11.

Glomerulopathy Induced by Immunization with a Peptide Derived from the Goodpasture Antigen α3IV-NC1
Hopfer H, Hünemörder S, Treder J, Turner J, Paust H, Meyer-Schwesinger C, Hopfer U, Sachs M, Peters A, Bucher-Kocaoglu B, Ahrens S, Panzer U, Mittrücker H
J IMMUNOL. 2015;194(8):3646-55.

TH1 and TH17 cells promote crescent formation in experimental autoimmune glomerulonephritis
Hünemörder S, Treder J, Ahrens S, Schumacher V, Paust H, Menter T, Matthys P, Kamradt T, Meyer-Schwesinger C, Panzer U, Hopfer H, Mittrücker H
J PATHOL. 2015;237(1):62-71.

Inflammation-Induced IL-6 Functions as a Natural Brake on Macrophages and Limits GN
Luig M, Kluger M, Goerke B, Meyer M, Nosko A, Yan I, Scheller J, Mittrücker H, Rose-John S, Stahl R, Panzer U, Steinmetz O
J AM SOC NEPHROL. 2015;26(7):1597-1607.

Nucleotide-Induced Membrane-Proximal Proteolysis Controls the Substrate Specificity of T Cell Ecto-ADP-Ribosyltransferase ARTC2.2
Menzel S, Rissiek B, Bannas P, Jakoby T, Miksiewicz M, Schwarz N, Nissen M, Haag F, Tholey A, Nolte F
J IMMUNOL. 2015;195(5):2057-2066.

Mannose 6 phosphorylation of lysosomal enzymes controls B cell functions
Otomo T, Schweizer M, Kollmann K, Schumacher V, Muschol N, Tolosa E, Mittrücker H, Braulke T
J CELL BIOL. 2015;208(2):171-80.

Association of hepatitis E virus and essential cryoglobulinemia?
Pischke S, Polywka S, Haag F, Iking-Konert C, Sterneck M, Lütgehetmann M, Dammermann W, Lüth S, Schirmer J
J CLIN VIROL. 2015;67:23-24.

The expression of CD39 on regulatory T cells is genetically driven and further upregulated at sites of inflammation
Rissiek A, Baumann I, Cuapio A, Mautner A, Kolster M, Arck P, Dodge-Khatami A, Mittrücker H, Nolte F, Haag F, Tolosa E
J AUTOIMMUN. 2015;58:12-20.

ADP-Ribosylation of P2X7 - A Matter of Life and Death for Regulatory T Cells and Natural Killer T Cells
Rissiek B, Haag F, Boyer O, Nolte F, Adriouch S
CURR TOP MICROBIOL. 2015;384:107-126.

P2X7 on Mouse T Cells: One Channel, Many Functions
Rissiek B, Haag F, Boyer O, Nolte F, Adriouch S
Front Immunol. 2015;6:204.

Function of the Th17/interleukin-17A immune response in murine lupus nephritis
Schmidt T, Paust H, Krebs C, Turner J, Kaffke A, Bennstein S, Koyro T, Peters A, Velden J, Hünemörder S, Haag F, Steinmetz O, Mittrücker H, Stahl R, Panzer U
ARTHRITIS RHEUM-US. 2015;67(2):475-87.

CD38 is expressed on inflammatory cells of the intestine and promotes intestinal inflammation
Schneider M, Schumacher V, Lischke T, Lücke K, Meyer-Schwesinger C, Velden J, Nolte F, Mittrücker H
PLOS ONE. 2015;10(5):e0126007.

Tuning IL-2 signaling by ADP-ribosylation of CD25
Teege S, Hann A, Miksiewicz M, MacMillan C, Rissiek B, Buck F, Menzel S, Nissen M, Bannas P, Haag F, Boyer O, Seman M, Adriouch S, Nolte F
SCI REP-UK. 2015;10(5):8959.

Selection of Nanobodies that Block the Enzymatic and Cytotoxic Activities of the Binary Clostridium Difficile Toxin CDT
Unger M, Eichhoff A, Schumacher L, Strysio M, Menzel S, Schwan C, Alzogaray V, Zylberman V, Seman M, Brandner J, Rohde H, Zhu K, Haag F, Mittrücker H, Goldbaum F, Aktories K, Nolte F
SCI REP-UK. 2015;5:7850.

Frontrunners of T cell activation: Initial, localized Ca2+ signals mediated by NAADP and the type 1 ryanodine receptor
Wolf I, Diercks B, Gattkowski E, Czarniak F, Kempski J, Werner R, Schetelig D, Mittrücker H, Schumacher V, von Osten M, Lodygin D, Flügel A, Fliegert R, Guse A
SCI SIGNAL. 2015;8(398):Art. ra102.

In vivo near-infrared fluorescence targeting of T cells: comparison of nanobodies and conventional monoclonal antibodies
Bannas P, Well L, Lenz A, Rissiek B, Haag F, Schmid J, Hochgräfe K, Trepel M, Adam G, Ittrich H, Nolte F
CONTRAST MEDIA MOL I. 2014;9(2):135-42.

Immune activation in amyloid-β-related angiitis correlates with decreased parenchymal amyloid-β plaque load
Bogner S, Bernreuther C, Matschke J, Barrera-Ocampo A, Sepulveda-Falla D, Leypoldt F, Magnus T, Haag F, Bergmann M, Brück W, Vogelgesang S, Glatzel M
NEURODEGENER DIS. 2014;13(1):38-44.

Mucolipidosis II-related mutations inhibit the exit from the endoplasmic reticulum and proteolytic cleavage of GlcNAc-1-phosphotransferase precursor protein (GNPTAB)
De Pace R, Coutinho M, Nolte F, Haag F, Prata M, Alves S, Braulke T, Pohl S
HUM MUTAT. 2014;35(3):368-76.

Evidence of promiscuous endothelial binding by Plasmodium falciparum-infected erythrocytes
Esser C, Bachmann A, Kuhn D, Schuldt K, Förster B, Thiel M, May J, Nolte F, Yáñez-Mó M, Sánchez-Madrid F, Schinkel A, Jalkanen S, Craig A, Bruchhaus I, Horstmann R
CELL MICROBIOL. 2014;16(5):701-8.

IRF4 and BATF are critical for CD8(+) T-cell function following infection with LCMV
Grusdat M, McIlwain D, Xu H, Pozdeev V, Knievel J, Crome S, Robert-Tissot C, Dress R, Pandyra A, Speiser D, Lang E, Maney S, Elford A, Hamilton S, Scheu S, Pfeffer K, Bode J, Mittrücker H, Lohoff M, Huber M, Häussinger D, Ohashi P, Mak T, Lang K, Lang P
CELL DEATH DIFFER. 2014;21(7):1050-60.

The Function of the Chemokine Receptor CXCR6 in the T Cell Response of Mice against Listeria monocytogenes
Heesch K, Raczkowski F, Schumacher V, Hünemörder S, Panzer U, Mittrücker H
PLOS ONE. 2014;9(5):e97701.

Dissemination of Orientia tsutsugamushi and inflammatory responses in a murine model of scrub typhus
Keller C, Hauptmann M, Kolbaum J, Gharaibeh M, Neumann M, Glatzel M, Fleischer B
PLOS NEGLECT TROP D. 2014;8(8):e3064.

Stat3 Programs Th17-Specific Regulatory T Cells to Control GN
Kluger M, Luig M, Wegscheid C, Goerke B, Paust H, Brix S, Yan I, Mittrücker H, Hagl B, Renner E, Tiegs G, Wiech T, Stahl R, Panzer U, Steinmetz O
J AM SOC NEPHROL. 2014;25(6):1291-302.

Functional autoantibodies against SSX-2 and NY-ESO-1 in multiple myeloma patients after allogeneic stem cell transplantation
Luetkens T, Kobold S, Cao Y, Ristic M, Schilling G, Tams S, Bartels B, Templin J, Bartels K, Hildebrandt Y, Yousef S, Marx A, Haag F, Bokemeyer C, Kröger N, Atanackovic D
CANCER IMMUNOL IMMUN. 2014;63(11):1151-62.

Lack of microbiota reduces innate responses and enhances adaptive immunity against Listeria monocytogenes infection
Mittrücker H, Seidel D, Bland P, Zarzycka A, Kaufmann S, Visekruna A, Steinhoff U
EUR J IMMUNOL. 2014;44(6):1710-5.

Heterogeneity in the Differentiation and Function of CD8(+) T Cells
Mittrücker H, Visekruna A, Huber M
ARCH IMMUNOL THER EX. 2014;62(6):449-458.

CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis
Nouailles G, Dorhoi A, Koch M, Zerrahn J, Weiner J, Faé K, Arrey F, Kuhlmann S, Bandermann S, Loewe D, Mollenkopf H, Vogelzang A, Meyer-Schwesinger C, Mittrücker H, McEwen G, Kaufmann S
J CLIN INVEST. 2014;124(3):1268-82.

Multidimensional scaling analysis identifies pathological and prognostically relevant profiles of circulating T-cells in chronic lymphocytic leukemia
Rissiek A, Schulze C, Bacher U, Schieferdecker A, Thiele B, Jacholkowski A, Flammiger A, Horn C, Haag F, Tiegs G, Zirlik K, Trepel M, Tolosa E, Binder M
INT J CANCER. 2014;135(10):2370-2379.

Technical Advance: a new cell preparation strategy that greatly improves the yield of vital and functional Tregs and NKT cells
Rissiek B, Danquah W, Haag F, Nolte F
J LEUKOCYTE BIOL. 2014;95(3):543-9.

Nanobodies as modulators of inflammation: potential applications for acute brain injury
Rissiek B, Nolte F, Magnus T
FRONT CELL NEUROSCI. 2014;8:344.

Clostridium difficile toxin CDT hijacks microtubule organization and reroutes vesicle traffic to increase pathogen adherence
Schwan C, Kruppke A, Nölke T, Schumacher L, Nolte F, Kudryashev M, Stahlberg H, Aktories K
P NATL ACAD SCI USA. 2014;111(6):2313-8.

Advancing the detection of maternal haematopoietic microchimeric cells in fetal immune organs in mice by flow cytometry
Solano M, Thiele K, Stelzer I, Mittrücker H, Arck P
Chimerism. 2014;0(0):1-4.

CD4+ T-cell help is required for effective CD8+ T cell-mediated resolution of acute viral hepatitis in mice
Trautmann T, Kozik J, Carambia A, Richter K, Lischke T, Schwinge D, Mittrücker H, Lohse A, Oxenius A, Wiegard C, Herkel J
PLOS ONE. 2014;9(1):e86348.

Exploring the MHC-peptide matrix of central tolerance in the human thymus
Adamopoulou E, Tenzer S, Hillen N, Klug P, Rota I, Tietz S, Gebhardt M, Stevanovic S, Schild H, Tolosa E, Melms A, Stoeckle C
NAT COMMUN. 2013;4:2039.

Cytokine concentrations and regulatory T cells in living donor and deceased donor liver transplant recipients
Briem-Richter A, Leuschner A, Haag F, Grabhorn E, Ganschow R
PEDIATR TRANSPLANT. 2013;17(2):185-90.

Peripheral blood biomarkers for the characterization of alloimmune reactivity after pediatric liver transplantation
Briem-Richter A, Leuschner A, Krieger T, Grabhorn E, Fischer L, Nashan B, Haag F, Ganschow R
PEDIATR TRANSPLANT. 2013;17(8):757-64.

Effect of prenatal steroid treatment on the developing immune system
Diepenbruck I, Much C, Krumbholz A, Kolster M, Thieme R, Thieme D, Diepenbruck S, Solano M, Arck P, Tolosa E
J MOL MED. 2013;91(11):1293-302.

4th EFIS-EJI South East European Summer School Immunology in Sarajevo
Fleischer B
EUR J IMMUNOL. 2013;43(1):10-2.

IL-6 controls the innate immune response against Listeria monocytogenes via classical IL-6 signaling
Hoge J, Yan I, Jänner N, Schumacher V, Chalaris A, Steinmetz O, Engel D, Scheller J, Rose-John S, Mittrücker H
J IMMUNOL. 2013;190(2):703-11.

IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis.
Huber M, Heink S, Pagenstecher A, Reinhard K, Ritter J, Visekruna A, Guralnik A, Bollig N, Jeltsch K, Heinemann C, Wittmann E, Buch T, Olivia P, Brüstle A, Brenner D, Mak T, Mittrücker H, Tackenberg B, Kamradt T, Lohoff M
J CLIN INVEST. 2013;123(1):247-260.

Relapsing cerebral aspergilloma associated with pregnancy.
Krützelmann A, Sobottka I, Fiehler J, Tolosa E, Gerloff C, Rosenkranz M
CLIN NEUROL NEUROSUR. 2013;115(7):1154-1156.

CD38 controls the innate immune response against Listeria monocytogenes
Lischke T, Heesch K, Schumacher V, Schneider M, Haag F, Nolte F, Mittrücker H
INFECT IMMUN. 2013;81(11):4091-9.

CD8-β ADP-ribosylation affects CD8(+) T-cell function
Lischke T, Schumacher V, Wesolowski J, Hurwitz R, Haag F, Nolte F, Mittrücker H
EUR J IMMUNOL. 2013;43(7):1828-38.

The art of blocking ADP-ribosyltransferases (ARTs): nanobodies as experimental and therapeutic tools to block mammalian and toxin ARTs
Menzel S, Rissiek B, Haag F, Goldbaum F, Nolte F
FEBS J. 2013;280(15):3543-50.

Physiology of ADP-ribosylation
Nolte F, Ziegler M
FEBS J. 2013;280(15):3483.

DNA-Encoded Flagellin Activates Toll-Like Receptor 5 (TLR5), Nod-like Receptor Family CARD Domain-Containing Protein 4 (NRLC4), and Acts as an Epidermal, Systemic, and Mucosal-Adjuvant
Nyström S, Bråve A, Falkeborn T, Devito C, Rissiek B, Johansson D, Schröder U, Uematsu S, Akira S, Hinkula J, Applequist S
Vaccines. 2013;1(4):415-443.

A new monoclonal anti-human CD83 antibody for flow cytometry, western blot analysis, and ELISA
Papp S, Richardt U, Fleischer B, Osterloh A
Monoclon Antib Immunodiagn Immunother. 2013;32(2):98-104.

The transcription factor Interferon Regulatory Factor 4 is required for the generation of protective effector CD8+ T cells
Raczkowski F, Ritter J, Heesch K, Schumacher V, Guralnik A, Höcker L, Raifer H, Klein M, Bopp T, Harb H, Kesper D, Pfefferle P, Grusdat M, Lang P, Mittrücker H, Huber M
P NATL ACAD SCI USA. 2013;110(37):15019-24.

Short-term TNFα shedding is independent of cytoplasmic phosphorylation or furin cleavage of ADAM17
Schwarz J, Broder C, Helmstetter A, Schmidt S, Yan I, Müller M, Schmidt-Arras D, Becker-Pauly C, Nolte F, Mittrücker H, Rabe B, Rose-John S, Chalaris A
BBA-MOL CELL RES. 2013;1833(12):3355-67.

Isolation of myeloid dendritic cells and epithelial cells from human thymus
Stoeckle C, Rota I, Tolosa E, Haller C, Melms A, Adamopoulou E
JOVE-J VIS EXP. 2013;(79):e50951.

Fine mapping and functional analysis of the multiple sclerosis risk gene CD6
Swaminathan B, Cuapio A, Alloza I, Matesanz F, Alcina A, García-Barcina M, Fedetz M, Fernández O, Lucas M, Orpez T, Pinto-Medel M, Otaegui D, Olascoaga J, Urcelay E, Ortiz M, Arroyo R, Oksenberg J, Antigüedad A, Tolosa E, Vandenbroeck K
PLOS ONE. 2013;8(4):e62376.

Plasmodium berghei sporozoite challenge of vaccinated BALB/c mice leads to the induction of humoral immunity and improved function of CD8(+) memory T cells
Tartz S, Deschermeier C, Retzlaff S, Heussler V, Sebo P, Fleischer B, Jacobs T
EUR J IMMUNOL. 2013;43(3):693-704.

Differential regulation of marginal zone and follicular B cell responses by CD83
Uhde M, Kuehl S, Richardt U, Fleischer B, Osterloh A
INT IMMUNOL. 2013;25(9):507-20.

Extracellular NAD(+): a danger signal hindering regulatory T cells.
Adriouch S, Haag F, Boyer O, Seman M, Koch Nolte F
MICROBES INFECT. 2012;14(14):1284-1292.

Extracellular NAD(+)
Adriouch S, Haag F, Boyer O, Seman M, Nolte F
MICROBES INFECT. 2012;14(14):1284-92.

Decreased hydrocortisone sensitivity of T cell function in multiple sclerosis-associated major depression.
Fischer A, Otte C, Krieger T, Nicholls R, Krüger S, Ziegler K, Schulz K, Heesen C, Gold S
PSYCHONEUROENDOCRINO. 2012;37(10):1712-1718.

Immunology for the Balkans.
Fleischer B
EUR J IMMUNOL. 2012;42(3):560-562.

The flavonoid fisetin attenuates postischemic immune cell infiltration, activation and infarct size after transient cerebral middle artery occlusion in mice.
Gelderblom M, Leypoldt F, Lewerenz J, Birkenmayer G, Orozco D, Ludewig P, Thundyil J, Arumugam T, Gerloff C, Tolosa E, Maher P, Magnus T
J CEREBR BLOOD F MET. 2012;32(5):835-843.

Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke.
Gelderblom M, Weymar A, Bernreuther C, Velden J, Arunachalam P, Steinbach K, Orthey E, Arumugam T, Leypoldt F, Simova O, Thom V, Friese M, Prinz I, Hölscher C, Glatzel M, Korn T, Gerloff C, Tolosa E, Magnus T
BLOOD. 2012;120(18):3793-3802.

Dynamic development of glucocorticoid resistance during autoimmune neuroinflammation.
Gold S, Sasidhar M, Lagishetty V, Spence R, Umeda E, Ziehn M, Krieger T, Schulz K, Heesen C, Hewison M, Voskuhl R
J CLIN ENDOCR METAB. 2012;97(8):1402-1410.

The sorting receptor Sortilin exhibits a dual function in exocytic trafficking of interferon-γ and granzyme A in T cells.
Herda S, Raczkowski F, Mittrücker H, Willimsky G, Gerlach K, Kühl A, Breiderhoff T, Willnow T, Dörken B, Höpken U, Rehm A
IMMUNITY. 2012;37(5):854-866.

Characterization of the renal CD4(+) T-cell response in experimental autoimmune glomerulonephritis.
Hopfer H, Holzer J, Hünemörder S, Paust H, Sachs M, Meyer-Schwesinger C, Turner J, Panzer U, Mittrücker H
KIDNEY INT. 2012;82(1):60-71.

Longitudinal analysis of tetanus- and influenza-specific IgG antibodies in myeloma patients.
Kobold S, Luetkens T, Bartels B, Cao Y, Hildebrandt Y, Sezer O, Reinhard H, Templin J, Bartels K, Lajmi N, Haag F, Bokemeyer C, Kröger N, Atanackovic D
Clin Dev Immunol. 2012;2012:134081.

IFN-γ production by allogeneic Foxp3+ regulatory T cells is essential for preventing experimental graft-versus-host disease.
Koenecke C, Lee C, Thamm K, Föhse L, Schafferus M, Mittrücker H, Floess S, Huehn J, Ganser A, Förster R, Prinz I
J IMMUNOL. 2012;189(6):2890-2896.

Efficient control of Plasmodium yoelii infection in BALB/c and C57BL/6 mice with pre-existing Strongyloides ratti infection.
Kolbaum J, Eschbach M, Steeg C, Jacobs T, Fleischer B, Breloer M
PARASITE IMMUNOL. 2012;34(7):388-393.

Nematode-induced interference with the anti-Plasmodium CD8+ T-cell response can be overcome by optimizing antigen administration.
Kolbaum J, Tartz S, Hartmann W, Helm S, Nagel A, Heussler V, Sebo P, Fleischer B, Jacobs T, Breloer M
EUR J IMMUNOL. 2012;42(4):890-900.

Expansion of HIV-specific T follicular helper cells in chronic HIV infection.
Lindqvist M, van Lunzen J, Soghoian D, Kuhl B, Ranasinghe S, Kranias G, Flanders M, Cutler S, Yudanin N, Muller M, Davis I, Farber D, Hartjen P, Haag F, Alter G, Schulze Zur Wiesch J, Streeck H
J CLIN INVEST. 2012;122(9):3271-3280.

Vaccination with Strongyloides ratti heat shock protein 60 increases susceptibility to challenge infection by induction of Th1 response.
Nouir N, Eschbach M, Piedavent M, Osterloh A, Kingsley M, Erttmann K, Brattig N, Liebau E, Fleischer B, Breloer M
VACCINE. 2012;30(5):862-871.

Chemokines play a critical role in the cross-regulation of Th1 and Th17 immune responses in murine crescentic glomerulonephritis.
Paust H, Turner J, Riedel J, Disteldorf E, Peters A, Schmidt T, Krebs C, Velden J, Mittrücker H, Steinmetz O, Stahl R, Panzer U
KIDNEY INT. 2012;82(1):72-83.

Antigen-specificity of oligoclonal abnormal protein bands in multiple myeloma after allogeneic stem cell transplantation.
Rahlff J, Trusch M, Haag F, Bacher U, Horst A, Schlüter H, Binder M
CANCER IMMUNOL IMMUN. 2012;61(10):1639-1651.

Immature renal dendritic cells recruit regulatory CXCR6(+) invariant natural killer T cells to attenuate crescentic GN.
Riedel J, Paust H, Turner J, Tittel A, Krebs C, Disteldorf E, Wegscheid C, Tiegs G, Velden J, Mittrücker H, Garbi N, Stahl R, Steinmetz O, Kurts C, Panzer U
J AM SOC NEPHROL. 2012;23(12):1987-2000.

Alternative splicing of the N-terminal cytosolic and transmembrane domains of P2X7 controls gating of the ion channel by ADP-ribosylation.
Schwarz N, Drouot L, Nicke A, Fliegert R, Boyer O, Guse A, Haag F, Adriouch S, Koch-Nolte F
PLOS ONE. 2012;7(7):41269.

Melittin modulates keratinocyte function through P2 receptor-dependent ADAM activation.
Sommer A, Fries A, Cornelsen I, Speck N, Koch Nolte F, Gimpl G, Andrä J, Bhakdi S, Reiss K
J BIOL CHEM. 2012;287(28):23678-23689.

Cathepsin S dominates autoantigen processing in human thymic dendritic cells.
Stoeckle C, Quecke P, Rückrich T, Burster T, Reich M, Weber E, Kalbacher H, Driessen C, Melms A, Tolosa E
J AUTOIMMUN. 2012;38(4):332-343.

Protective role for CCR5 in murine lupus nephritis.
Turner J, Paust H, Mathey S, Bramke P, Krebs C, Steinmetz O, Velden J, Haag F, Stahl R, Panzer U
AM J PHYSIOL-RENAL. 2012;302(11):1503-1515.

Renal IL-17 expression in human ANCA-associated glomerulonephritis.
Velden J, Paust H, Hoxha E, Turner J, Steinmetz O, Wolf G, Jabs W, Özcan F, Beige J, Heering P, Schröder S, Kneißler U, Disteldorf E, Mittrücker H, Stahl R, Helmchen U, Panzer U
AM J PHYSIOL-RENAL. 2012;302(12):1663-1673.

Single-domain llama antibodies as specific intracellular inhibitors of SpvB, the actin ADP-ribosylating toxin of Salmonella typhimurium.
Alzogaray V, Danquah W, Aguirre A, Urrutia M, Berguer P, Eleonora G, Haag F, Koch Nolte F, Goldbaum F
FASEB J. 2011;25(2):526-534.

Transgenic overexpression of toxin-related ecto-ADP-ribosyltransferase ART2.2 sensitizes T cells but not B cells to NAD-induced cell death.
Bannas P, Scheuplein F, Well L, Hermans-Borgmeyer I, Haag F, Koch Nolte F
MOL IMMUNOL. 2011;48(15-16):1762-1770.

Contrast-Enhanced [(18)F]fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography for Staging and Radiotherapy Planning in Patients with Anal Cancer.
Bannas P, Weber C, Adam G, Frenzel T, Derlin T, Mester J, Klutmann S
INT J RADIAT ONCOL. 2011;81(2):445-451.

Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail.
Behnke J, Schneppenheim J, Koch Nolte F, Haag F, Saftig P, Schröder B
FEBS LETT. 2011;585(19):2951-2957.

[Diagnosis and therapy of cutaneous and mucocutaneous Leishmaniasis in Germany].
Boecken G, Sunderkötter C, Bogdan C, Weitzel T, Fischer M, Müller A, Löbermann M, Anders G, von Stebut E, Schunk M, Burchard G, Grobusch M, Bialek R, Harms-Zwingenberger G, Fleischer B, Pietras M, Faulde M, Erkens K, Dermatology G, Medicine G, Chemotherapy G
J DTSCH DERMATOL GES. 2011;9 Suppl 8:1-51.

CD38 exacerbates focal cytokine production, postischemic inflammation and brain injury after focal cerebral ischemia.
Choe C, Lardong K, Gelderblom M, Ludewig P, Leypoldt F, Koch Nolte F, Gerloff C, Magnus T
PLOS ONE. 2011;6(5):19046.

CXCR3 deficiency exacerbates liver disease and abrogates tolerance in a mouse model of immune-mediated hepatitis.
Erhardt A, Wegscheid C, Claaß B, Carambia A, Herkel J, Mittrücker H, Panzer U, Tiegs G
J IMMUNOL. 2011;186(9):5284-5293.

Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding.
Garbers C, Jänner N, Chalaris A, Moss M, Floss D, Meyer D, Koch Nolte F, Rose-John S, Scheller J
J BIOL CHEM. 2011;286(17):14804-14811.

Endocrine and immune substrates of depressive symptoms and fatigue in multiple sclerosis patients with comorbid major depression.
Gold S, Krüger S, Ziegler K, Krieger T, Schulz K, Otte C, Heesen C
J NEUROL NEUROSUR PS. 2011;82(7):814-818.

A novel and divergent role of granzyme A and B in resistance to helminth infection.
Hartmann W, Marsland B, Otto B, Urny J, Fleischer B, Korten S
J IMMUNOL. 2011;186(4):2472-2481.

Progress in the function and regulation of ADP-Ribosylation.
Hottiger M, Boothby M, Koch Nolte F, Lüscher B, Martin N, Plummer R, Wang Z, Ziegler M
SCI SIGNAL. 2011;4(174):5.

Monoclonal antibodies for the identification and purification of vNAR domains and IgNAR immunoglobulins from the horn shark Heterodontus francisci.
Juarez K, Dubberke G, Lugo P, Koch Nolte F, Buck F, Haag F, Licea A
HYBRIDOMA. 2011;30(4):323-329.

Patients with multiple myeloma develop SOX2-specific autoantibodies after allogeneic stem cell transplantation.
Kobold S, Tams S, Luetkens T, Cao Y, Sezer O, Bartels B, Reinhard H, Templin J, Bartels K, Hildebrandt Y, Lajmi N, Marx A, Haag F, Bokemeyer C, Kröger N, Atanackovic D
Clin Dev Immunol. 2011;2011:302145.

Compartmentation of NAD+-dependent signalling.
Koch Nolte F, Fischer S, Haag F, Ziegler M
FEBS LETT. 2011;585(11):1651-1656.

Strategies for the identification of arginine ADP-ribosylation sites.
Laing S, Koch Nolte F, Haag F, Buck F
J PROTEOMICS. 2011;75(1):169-176.

ADP-ribosylation of arginine.
Laing S, Unger M, Koch Nolte F, Haag F
AMINO ACIDS. 2011;41(2):257-269.

IRF4 deficiency abrogates lupus nephritis despite enhancing systemic cytokine production.
Lech M, Weidenbusch M, Kulkarni O, Ryu M, Darisipudi M, Susanti H, Mittrücker H, Mak T, Anders H
J AM SOC NEPHROL. 2011;22(8):1443-1452.

Regulatory T cells control the Th1 immune response in murine crescentic glomerulonephritis.
Paust H, Ostmann A, Erhardt A, Turner J, Velden J, Mittrücker H, Sparwasser T, Panzer U, Tiegs G
KIDNEY INT. 2011;80(2):154-164.

CD38: a NAADP degrading enzyme.
Schmid F, Bruhn S, Weber K, Mittrücker H, Guse A
FEBS LETT. 2011;585(22):3544-3548.

Characterisation of a novel glycosylphosphatidylinositol-anchored mono-ADP-ribosyltransferase isoform in ovary cells.
Stilla A, Simone D, Dani N, Krebs C, Arrizza A, Corda D, Haag F, Koch Nolte F, Maria D
EUR J CELL BIOL. 2011;90(8):665-677.

Quantitative magnetic resonance imaging of enzyme activity on the cell surface: in vitro and in vivo monitoring of ADP-ribosyltransferase 2 on T cells.
Bannas P, Graumann O, Balcerak P, Peldschus K, Kaul M, Hohenberg H, Haag F, Adam G, Ittrich H, Koch Nolte F
MOL IMAGING. 2010;9(4):211-222.

Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway.
Hubert S, Rissiek B, Klages K, Huehn J, Sparwasser T, Haag F, Koch Nolte F, Boyer O, Seman M, Adriouch S
J EXP MED. 2010;207(12):2561-2568.

Ischemia reperfusion induces IFN regulatory factor 4 in renal dendritic cells, which suppresses postischemic inflammation and prevents acute renal failure.
Lassen S, Lech M, Römmele C, Mittrücker H, Mak T, Anders H
J IMMUNOL. 2010;185(3):1976-1983.

A recombinant heavy chain antibody approach blocks ART2 mediated deletion of an iNKT cell population that upon activation inhibits autoimmune diabetes.
Scheuplein F, Rissiek B, Driver J, Chen Y, Koch Nolte F, Serreze D
J AUTOIMMUN. 2010;34(2):145-154.

TLR2-, TLR4- and Myd88-independent acquired humoral and cellular immunity against Salmonella enterica serovar Typhimurium.
Seibert S, Mex P, Köhler A, Kaufmann S, Mittrücker H
IMMUNOL LETT. 2010;127(2):126-134.

Expression of human cathepsin L or human cathepsin V in mouse thymus mediates positive selection of T helper cells in cathepsin L knock-out mice
Sevenich L, Hagemann S, Stoeckle C, Tolosa E, Peters C, Reinheckel T
BIOCHIMIE. 2010;92(11):1674-80.

CCR6 recruits regulatory T cells and Th17 cells to the kidney in glomerulonephritis.
Turner J, Paust H, Steinmetz O, Peters A, Riedel J, Erhardt A, Wegscheid C, Velden J, Fehr S, Mittrücker H, Tiegs G, Stahl R, Panzer U
J AM SOC NEPHROL. 2010;21(6):974-985.

Characterisation of the R276A gain-of-function mutation in the ectodomain of murine P2X7.
Adriouch S, Scheuplein F, Bähring R, Seman M, Boyer O, Koch Nolte F, Haag F
PURINERG SIGNAL. 2009;5(2):151-161.

Priming of CD8+ and CD4+ T cells in experimental leishmaniasis is initiated by different dendritic cell subtypes.
Brewig N, Kissenpfennig A, Malissen B, Veit A, Bickert T, Fleischer B, Mostböck S, Ritter U
J IMMUNOL. 2009;182(2):774-783.

Phenotypical Characterization of Human Th17 Cells Unambiguously Identified by Surface IL-17A Expression
Brucklacher-Waldert V, Steinbach K, Lioznov M, Kolster M, Hölscher C, Tolosa E
J IMMUNOL. 2009;183:5494-5501.

ATP induces P2X7 receptor-independent cytokine and chemokine expression through P2X1 and P2X3 receptors in murine mast cells.
Bulanova E, Budagian V, Orinska Z, Koch Nolte F, Haag F, Bulfone-Paus S
J LEUKOCYTE BIOL. 2009;85(4):692-702.

Sialylated ligands on pathogenic Trypanosoma cruzi interact with Siglec-E (sialic acid-binding Ig-like lectin-E).
Erdmann H, Steeg C, Koch Nolte F, Fleischer B, Jacobs T
CELL MICROBIOL. 2009;11(11):1600-1611.

Basal and inducible expression of the thiol-sensitive ART2.1 ecto-ADP-ribosyltransferase in myeloid and lymphoid leukocytes.
Hong S, Brass A, Seman M, Haag F, Koch Nolte F, Dubyak G
PURINERG SIGNAL. 2009;5(3):369-383.

Differential regulation of P2X7 receptor activation by extracellular nicotinamide adenine dinucleotide and ecto-ADP-ribosyltransferases in murine macrophages and T cells.
Hong S, Schwarz N, Brass A, Seman M, Haag F, Koch Nolte F, Schilling W, Dubyak G
J IMMUNOL. 2009;183(1):578-592.

CEACAM1+ myeloid cells control angiogenesis in inflammation.
Horst A, Bickert T, Brewig N, Ludewig P, van Rooijen N, Schumacher U, Beauchemin N, Ito W, Fleischer B, Wagener C, Ritter U
BLOOD. 2009;113(26):6726-6736.

A Th17-like developmental process leads to CD8(+) Tc17 cells with reduced cytotoxic activity.
Huber M, Heink S, Grothe H, Guralnik A, Reinhard K, Elflein K, Hünig T, Mittrücker H, Brüstle A, Kamradt T, Lohoff M
EUR J IMMUNOL. 2009;39(7):1716-1725.

Molecular interaction of Siglecs (sialic acid-binding Ig-like lectins) with sialylated ligands on Trypanosoma cruzi.
Jacobs T, Erdmann H, Fleischer B
EUR J CELL BIOL. 2009.

Cloning, expression, purification and crystallization as well as X-ray fluorescence and preliminary X-ray diffraction analyses of human ADP-ribosylhydrolase 1.
Kernstock S, Koch Nolte F, Mueller-Dieckmann J, Weiss M, Mueller-Dieckmann C
ACTA CRYSTALLOGR F. 2009;65(5):529-532.

Emerging roles of NAD+ and its metabolites in cell signaling.
Koch Nolte F, Haag F, Guse A, Lund F, Ziegler M
SCI SIGNAL. 2009;2(57):1.

Orientia tsutsugamushi bacteremia and cytokine levels in Vietnamese scrub typhus patients.
Kramme S, An L, Khoa N, Trin L, Tannich E, Rybniker J, Fleischer B, Drosten C, Panning M
J CLIN MICROBIOL. 2009;47(3):586-589.

Engagement of CD83 on B cells modulates B cell function in vivo.
Kretschmer B, Lüthje K, Schneider S, Fleischer B, Breloer M
J IMMUNOL. 2009;182(5):2827-2834.

Proinflammatory and osteoclastogenic effects of beta-tricalciumphosphate and hydroxyapatite particles on human mononuclear cells in vitro.
Lange T, Schilling A, Peters F, Haag F, Morlock M, Rueger J, Amling M
BIOMATERIALS. 2009;30(29):5312-5318.

Heat shock protein 60 (HSP60) stimulates neutrophil effector functions.
Osterloh A, Geisinger F, Piédavent M, Fleischer B, Brattig N, Breloer M
J LEUKOCYTE BIOL. 2009.

The IL-23/Th17 axis contributes to renal injury in experimental glomerulonephritis.
Paust H, Turner J, Steinmetz O, Peters A, Heymann F, Hölscher C, Wolf G, Kurts C, Mittrücker H, Stahl R, Panzer U
J AM SOC NEPHROL. 2009;20(5):969-979.

The tumor-associated antigen EBAG9 negatively regulates the cytolytic capacity of mouse CD8+ T cells.
Rüder C, Höpken U, Wolf J, Mittrücker H, Engels B, Erdmann B, Wollenzin S, Uckert W, Dörken B, Rehm A
J CLIN INVEST. 2009;119(8):2184-2203.

NAD+ and ATP released from injured cells induce P2X7-dependent shedding of CD62L and externalization of phosphatidylserine by murine T cells.
Scheuplein F, Schwarz N, Adriouch S, Krebs C, Bannas P, Rissiek B, Seman M, Haag F, Koch Nolte F
J IMMUNOL. 2009;182(5):2898-2908.

A role for IL-18 in protective immunity against Mycobacterium tuberculosis.
Schneider B, Korbel D, Hagens K, Koch M, Raupach B, Enders J, Kaufmann S, Mittrücker H, Schaible U
EUR J IMMUNOL. 2009;40(2):396-405.

Deficiency of the tetraspanin CD63 associated with kidney pathology but normal lysosomal function.
Schröder J, Lüllmann-Rauch R, Himmerkus N, Pleines I, Nieswandt B, Orinska Z, Koch Nolte F, Schröder B, Bleich M, Saftig P
MOL CELL BIOL. 2009;29(4):1083-1094.

Activation of the P2X7 ion channel by soluble and covalently bound ligands.
Schwarz N, Fliegert R, Adriouch S, Seman M, Guse A, Haag F, Koch Nolte F
PURINERG SIGNAL. 2009;5(2):139-149.

Detection of aberrant transcription of major histocompatibility complex class II antigen presentation genes in chronic lymphocytic leukaemia identifies HLA-DOA mRNA as a prognostic factor for survival.
Souwer [, Yuri [, Chamuleau [, Martine E, Loosdrecht v, Arjan A, Tolosa E, Eva [, Jorritsma [, Tineke [, Muris [, Jettie J, Poppel D, Marion J, Snel [, Sander N, Corput v, Lisette [, Ossenkoppele [, Gert J, Meijer [, Chris J, Neefjes [, Jacques J, van Ham M
BRIT J HAEMATOL. 2009;145(3):334-343.

Limited role of CD4+Foxp3+ regulatory T cells in the control of experimental cerebral malaria.
Steeg C, Adler G, Sparwasser T, Fleischer B, Jacobs T
J IMMUNOL. 2009;183(11):7014-7022.

CXCR3 mediates renal Th1 and Th17 immune response in murine lupus nephritis.
Steinmetz O, Turner J, Paust H, Lindner M, Peters A, Heiss K, Velden J, Hopfer H, Fehr S, Krieger T, Meyer-Schwesinger C, Meyer T, Helmchen U, Mittrücker H, Stahl R, Panzer U
J IMMUNOL. 2009;183(7):4693-4704.

Mast cell-mediated antigen presentation regulates CD8+ T cell effector functions.
Stelekati E, Bahri R, D'Orlando O, Orinska Z, Mittrücker H, Langenhaun R, Glatzel M, Bollinger A, Paus R, Bulfone-Paus S
IMMUNITY. 2009;31(4):665-676.

Cathepsin W expressed exclusively in CD8+ T cells and NK cells, is secreted during target cell killing but is not essential for cytotoxicity in human CTLs.
Stoeckle C, Gouttefangeas C, Hammer M, Weber E, Melms A, Tolosa E
EXP HEMATOL. 2009;37(2):266-275.

Cathepsin G is differentially expressed in primary human antigen-presenting cells.
Stoeckle C, Sommandas V, Adamopoulou E, Belisle K, Schiekofer S, Melms A, Weber E, Driessen C, Fleischer B, Tolosa E, Burster T
CELL IMMUNOL. 2009;255(1-2):41-45.

Single domain antibodies: promising experimental and therapeutic tools in infection and immunity.
Wesolowski J, Alzogaray V, Reyelt J, Unger M, Juarez K, Urrutia M, Cauerhff A, Danquah W, Rissiek B, Scheuplein F, Schwarz N, Adriouch S, Boyer O, Seman M, Licea A, Serreze D, Goldbaum F, Haag F, Koch Nolte F
MED MICROBIOL IMMUN. 2009.

ADP-ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site.
Adriouch S, Bannas P, Schwarz N, Fliegert R, Guse A, Seman M, Haag F, Koch Nolte F
FASEB J. 2008;22(3):861-869.

Natural killer cells are required for accelerated type 1 diabetes driven by interferon-beta
Alba A, Planas R, Clemente X, Carrillo J, Ampudia R, Puertas M, Pastor X, Tolosa E, Pujol-Borrell R, Verdaguer J, Vives-Pi M
CLIN EXP IMMUNOL. 2008;151(3):467-75.

CD83 regulates lymphocyte maturation, activation and homeostasis.
Breloer M, Fleischer B
TRENDS IMMUNOL. 2008;29(4):186-194.

ICOS controls the pool size of effector-memory and regulatory T cells.
Burmeister Y, Lischke T, Dahler A, Mages H, Lam K, Coyle A, Kroczek R, Hutloff A
J IMMUNOL. 2008;180(2):774-782.

High sensitivity of intestinal CD8+ T cells to nucleotides indicates P2X7 as a regulator for intestinal T cell responses.
Heiss K, Jänner N, Mähnss B, Schumacher V, Koch Nolte F, Haag F, Mittrücker H
J IMMUNOL. 2008;181(6):3861-3869.

Restricted expression of C-type lectin-like natural killer receptors by CD8 T cells in the murine small intestine.
Jänner N, Hahnke K, Mollenkopf H, Steinhoff U, Kaufmann S, Mittrücker H
IMMUNOLOGY. 2008;125(1):38-47.

Human cytomegalovirus infection interferes with major histocompatibility complex type II maturation and endocytic proteases in dendritic cells at multiple levels.
Kessler T, Reich M, Jahn G, Tolosa E, Beck A, Kalbacher H, Overkleeft H, Schempp S, Driessen C
J GEN VIROL. 2008;89(Pt 10):2427-2436.

Q fever in young children, Ghana
Kobbe R, Kramme S, Kreuels B, Adjei S, Kreuzberg C, Panning M, Adjei O, Fleischer B, May J
EMERG INFECT DIS. 2008;14(2):344-6.

Mammalian ADP-ribosyltransferases and ADP-ribosylhydrolases.
Koch Nolte F, Kernstock S, Mueller-Dieckmann C, Weiss M, Haag F
FRONT BIOSCI-LANDMRK. 2008;13:6716-6729.

CD83 on murine APC does not function as a costimulatory receptor for T cells.
Kretschmer B, Lüthje K, Ehrlich S, Osterloh A, Piedavent M, Fleischer B, Breloer M
IMMUNOL LETT. 2008;120(1-2):87-95.

Requirement of secondary lymphoid tissues for the induction of primary and secondary T cell responses against Listeria monocytogenes.
Kursar M, Jänner N, Pfeffer K, Brinkmann V, Kaufmann S, Mittrücker H
EUR J IMMUNOL. 2008;38(1):127-138.

CD83 regulates splenic B cell maturation and peripheral B cell homeostasis.
Lüthje K, Kretschmer B, Fleischer B, Breloer M
INT IMMUNOL. 2008;20(8):949-960.

Hierarchy of nonhomologous end-joining, single-strand annealing and gene conversion at site-directed DNA double-strand breaks.
Mansour W, Schumacher S, Rosskopf R, Rhein T, Schmidt-Petersen F, Gatzemeier F, Haag F, Borgmann K, Willers H, Dahm-Daphi J
NUCLEIC ACIDS RES. 2008;36(12):4088-4098.

Structure of mouse ADP-ribosylhydrolase 3 (mARH3).
Mueller-Dieckmann C, Kernstock S, Mueller-Dieckmann J, Weiss M, Koch Nolte F
ACTA CRYSTALLOGR F. 2008;64(3):156-162.

Functional localization of two poly(ADP-ribose)-degrading enzymes to the mitochondrial matrix.
Niere M, Kernstock S, Koch Nolte F, Ziegler M
MOL CELL BIOL. 2008;28(2):814-824.

Hsp60-mediated T cell stimulation is independent of TLR4 and IL-12.
Osterloh A, Veit A, Gessner A, Fleischer B, Breloer M
INT IMMUNOL. 2008;20(3):433-443.

The cellular localization of autotaxin impacts on its biological functions in human thyroid carcinoma cells.
Seifert A, Klonisch T, Wulfaenger J, Haag F, Dralle H, Langner J, Hoang-Vu C, Kehlen A
ONCOL REP. 2008;19(6):1485-1491.

Complete protection against P. berghei malaria upon heterologous prime/boost immunization against circumsporozoite protein employing Salmonella type III secretion system and Bordetella adenylate cyclase toxoid.
Tartz S, Rüssmann H, Kamanova J, Sebo P, Sturm A, Heussler V, Fleischer B, Jacobs T
VACCINE. 2008;26(47):5935-5943.

CCR5 deficiency aggravates crescentic glomerulonephritis in mice.
Turner J, Paust H, Steinmetz O, Peters A, Meyer-Schwesinger C, Heymann F, Helmchen U, Fehr S, Horuk R, Wenzel U, Kurts C, Mittrücker H, Stahl R, Panzer U
J IMMUNOL. 2008;181(9):6546-6556.

Human CD4+ T cells displaying viral epitopes elicit a functional virus-specific memory CD8+ T cell response.
Adamopoulou E, Diekmann J, Tolosa E, Kuntz G, Einsele H, Rammensee H, Topp M
J IMMUNOL. 2007;178(9):5465-5472.

NAD+ released during inflammation participates in T cell homeostasis by inducing ART2-mediated death of naive T cells in vivo.
Adriouch S, Hubert S, Pechberty S, Koch Nolte F, Haag F, Seman M
J IMMUNOL. 2007;179(1):186-194.

CD83 is a regulator of murine B cell function in vivo.
Breloer M, Kretschmer B, Lüthje K, Ehrlich S, Ritter U, Bickert T, Steeg C, Fillatreau S, Hoehlig K, Lampropoulou V, Fleischer B
EUR J IMMUNOL. 2007;37(3):634-648.

Interferon-gamma regulates cathepsin G activity in microglia-derived lysosomes and controls the proteolytic processing of myelin basic protein in vitro
Burster T, Beck A, Poeschel S, Øren A, Baechle D, Reich M, Roetzschke O, Falk K, Boehm B, Youssef S, Kalbacher H, Overkleeft H, Tolosa E, Driessen C
IMMUNOLOGY. 2007;121(1):82-93.

Increased frequency of CD4+ CD25+ regulatory T cells in the cerebrospinal fluid but not in the blood of multiple sclerosis patients
Feger U, Luther C, Poeschel S, Melms A, Tolosa E, Wiendl H
CLIN EXP IMMUNOL. 2007;147(3):412-8.

HLA-G expression defines a novel regulatory T-cell subset present in human peripheral blood and sites of inflammation.
Feger U, Tolosa E, Huang Y, Waschbisch A, Biedermann T, Melms A, Wiendl H
BLOOD. 2007;110(2):568-577.

Regional IFNgamma expression is insufficient for efficacious control of food-borne bacterial pathogens at the gut epithelial barrier.
Gajendran N, Mittrücker H, Bordasch K, Heinemann E, Koch M, Kaufmann S
INT IMMUNOL. 2007;19(9):1075-1081.

Extracellular NAD and ATP: Partners in immune cell modulation.
Haag F, Adriouch S, Brass A, Jung C, Hübener S, Scheuplein F, Bannas P, Seman M, Koch-Nolte F
PURINERG SIGNAL. 2007;3(1-2):71-81.

Autophagic cell death induced by TrkA receptor activation in human glioblastoma cells.
Hansen K, Wagner B, Hamel W, Schweizer M, Haag F, Westphal M, Lamszus K
J NEUROCHEM. 2007;103(1):259-275.

Lipopolysaccharide, IFN-gamma, and IFN-beta induce expression of the thiol-sensitive ART2.1 Ecto-ADP-ribosyltransferase in murine macrophages.
Hong S, Brass A, Seman M, Haag F, Koch Nolte F, Dubyak G
J IMMUNOL. 2007;179(9):6215-6227.

Monitoring the expression of purinoceptors and nucleotide-metabolizing ecto-enzymes with antibodies directed against proteins in native conformation.
Hübener S, Jung C, Adriouch S, Dubberke G, Seyfried F, Seman M, Haag F, Koch Nolte F
PURINERG SIGNAL. 2007;3(4):359-366.

Single domain antibodies from llama effectively and specifically block T cell ecto-ADP-ribosyltransferase ART2.2 in vivo.
Koch Nolte F, Reyelt J, Schössow B, Schwarz N, Scheuplein F, Rothenburg S, Haag F, Alzogaray V, Cauerhff A, Goldbaum F
FASEB J. 2007;21(13):3490-3498.

CD83 modulates B Cell function in vitro: increased IL-10 and reduced Ig secretion by CD83Tg B cells.
Kretschmer B, Lüthje K, Guse A, Ehrlich S, Koch Nolte F, Haag F, Fleischer B, Breloer M
PLOS ONE. 2007;2(1):755.

Cutting Edge: Regulatory T cells prevent efficient clearance of Mycobacterium tuberculosis.
Kursar M, Koch M, Mittrücker H, Nouailles G, Bonhagen K, Kamradt T, Kaufmann S
J IMMUNOL. 2007;178(5):2661-2665.

CTLA-4 blockade differentially influences the outcome of non-lethal and lethal Plasmodium yoelii infections.
Lepenies B, Gaworski I, Tartz S, Langhorne J, Fleischer B, Jacobs T
MICROBES INFECT. 2007;9(6):687-694.

Dementia and leukoencephalopathy due to lymphomatosis cerebri.
Lewerenz J, Ding X, Matschke J, Schnabel C, Emami P, von Borczyskowski D, Buchert R, Krieger T, De Wit M, Münchau A
J NEUROL NEUROSUR PS. 2007;78(7):777-778.

Poor correlation between BCG vaccination-induced T cell responses and protection against tuberculosis.
Mittrücker H, Steinhoff U, Köhler A, Krause M, Lazar D, Mex P, Miekley D, Kaufmann S
P NATL ACAD SCI USA. 2007;104(30):12434-12439.

Chemokine receptor CXCR3 mediates T cell recruitment and tissue injury in nephrotoxic nephritis in mice.
Panzer U, Steinmetz O, Paust H, Meyer-Schwesinger C, Peters A, Turner J, Zahner G, Heymann F, Kurts C, Hopfer H, Helmchen U, Haag F, Schneider A, Stahl R
J AM SOC NEPHROL. 2007;18(7):2071-2084.

Higher frequency of regulatory T cells in the elderly and increased suppressive activity in neurodegeneration.
Rosenkranz D, Weyer S, Tolosa E, Gaenslen A, Berg D, Leyhe T, Gasser T, Stoltze L
J NEUROIMMUNOL. 2007;188(1-2):117-127.

Standardization of autoimmune diagnostics in Germany: activities of the German group in the European Autoimmune Standardization Initiative.
Sack U, Conrad K, Csernok E, Frank I, Haass M, Krieger T, Seyfarth M, Schlosser U, Schmidt R, Witte T
ANN NY ACAD SCI. 2007;1109:31-36.

FK778 in experimental xenotransplantation: a detailed analysis of drug efficacy.
Schrepfer S, Deuse T, Koch Nolte F, Krieger T, Haddad M, Schäfer H, Pelletier M, Robbins R, Reichenspurner H
J HEART LUNG TRANSPL. 2007;26(1):70-77.

Polymorphisms in the cathepsin L2 (CTSL2) gene show association with type 1 diabetes and early-onset myasthenia gravis.
Viken M, Sollid H, Joner G, Dahl-Jørgensen K, Rønningen K, Undlien D, Flatø B, Selvaag A, Førre Ø, Kvien T, Thorsby E, Melms A, Tolosa E, Lie B
HUM IMMUNOL. 2007;68(9):748-755.

Cloning and characterization of an adenoviral vector for highly efficient and doxycycline-suppressible expression of bioactive human single-chain interleukin 12 in colon cancer.
Wulff H, Krieger T, Krüger K, Stahmer I, Thaiss F, Schäfer H, Block A
BMC BIOTECHNOL. 2007;7:35.

Characterization of a conduit system containing laminin-5 in the human thymus
Drumea-Mirancea M, Wessels J, Müller C, Essl M, Eble J, Tolosa E, Koch M, Reinhardt D, Sixt M, Sorokin L, Stierhof Y, Schwarz H, Klein G
J CELL SCI. 2006;119(Pt 7):1396-405.

Medical patients' attitudes toward emotional problems and their treatment. What do they really want?
Löwe B, Schulz U, Gräfe K, Wilke S
J GEN INTERN MED. 2006;21(1):39-45.

Thymus and myasthenia gravis
Melms A, Luther C, Stoeckle C, Pöschel S, Schroth P, Varga M, Wienhold W, Tolosa E
Acta neurologica Scandinavica. Supplementum. 2006;183:12-3.

Differential processing of autoantigens in lysosomes from human monocyte-derived and peripheral blood dendritic cells
Burster T, Beck A, Tolosa E, Schnorrer P, Weissert R, Reich M, Kraus M, Kalbacher H, Häring H, Weber E, Overkleeft H, Driessen C
J IMMUNOL. 2005;175(9):5940-9.

Human alpha-defensins neutralize anthrax lethal toxin and protect against its fatal consequences
Kim C, Gajendran N, Mittrücker H, Weiwad M, Song Y, Hurwitz R, Wilmanns M, Fischer G, Kaufmann S
P NATL ACAD SCI USA. 2005;102(13):4830-5.

Differential requirements for the chemokine receptor CCR7 in T cell activation during Listeria monocytogenes infection
Kursar M, Höpken U, Koch M, Köhler A, Lipp M, Kaufmann S, Mittrücker H
J EXP MED. 2005;201(9):1447-57.

Detecting and monitoring depression with a two-item questionnaire (PHQ-2).
Löwe B, Kroenke K, Gräfe K
J PSYCHOSOM RES. 2005;58(2):163-171.

Decreased frequency of intrathymic regulatory T cells in patients with myasthenia-associated thymoma
Luther C, Poeschel S, Varga M, Melms A, Tolosa E
J NEUROIMMUNOL. 2005;164(1-2):124-8.

Alternatively spliced transcripts of the thymus-specific protease PRSS16 are differentially expressed in human thymus
Luther C, Wienhold W, Oehlmann R, Heinemann M, Melms A, Tolosa E
GENES IMMUN . 2005;6(1):1-7.

Expression of insulin-like factor 3 protein in the rat testis during fetal and postnatal development and in relation to cryptorchidism induced by in utero exposure to di (n-Butyl) phthalate
McKinnell C, Sharpe R, Mahood K, Hallmark N, Scott H, Ivell R, Staub C, Jégou B, Haag F, Koch-Nolte F, Hartung S
ENDOCRINOLOGY. 2005;146(10):4536-44.

Autistic effector T cells in mice with a point mutation in the LAT adaptor fail to respond to Listeria monocytogenes infection
Prinz I, Kursar M, Mittrücker H, Aguado E, Steinhoff U, Kaufmann S, Malissen B
INT IMMUNOL. 2005;17(7):951-7.

Targeted delivery of the ErbB2/HER2 tumor antigen to professional APCs results in effective antitumor immunity
Rohrbach F, Weth R, Kursar M, Sloots A, Mittrücker H, Wels W
J IMMUNOL. 2005;174(9):5481-9.

Systemic NKG2D down-regulation impairs NK and CD8 T cell responses in vivo
Wiemann K, Mittrücker H, Feger U, Welte S, Yokoyama W, Spies T, Rammensee H, Steinle A
J IMMUNOL. 2005;175(2):720-9.

Different patterns of nicotinic acetylcholine receptor subunit transcription in human thymus
Bruno R, Sabater L, Tolosa E, Sospedra M, Ferrer-Francesch X, Coll J, Foz M, Melms A, Pujol-Borrell R
J NEUROIMMUNOL. 2004;149(1-2):147-59.

Cathepsin G, and not the asparagine-specific endoprotease, controls the processing of myelin basic protein in lysosomes from human B lymphocytes
Burster T, Beck A, Tolosa E, Marin-Esteban V, Rötzschke O, Falk K, Lautwein A, Reich M, Brandenburg J, Schwarz G, Wiendl H, Melms A, Lehmann R, Stevanovic S, Kalbacher H, Driessen C
J IMMUNOL. 2004;172(9):5495-503.

Vaccination against tuberculosis
Kaufmann S, Mittrücker H
Seminars in respiratory and critical care medicine. 2004;25(3):345-52.

Expression of selectin ligands on murine effector and IL-10-producing CD4+ T cells from non-infected and infected tissues
Kretschmer U, Bonhagen K, Debes G, Mittrücker H, Erb K, Liesenfeld O, Zaiss D, Kamradt T, Syrbe U, Hamann A
EUR J IMMUNOL. 2004;34(11):3070-81.

Antigen-specific CD8+ T cell responses in intestinal tissues during murine listeriosis
Kursar M, Bonhagen K, Köhler A, Kamradt T, Kaufmann S, Mittrücker H, Mittrücker H
MICROBES INFECT. 2004;6(1):8-16.

Depletion of CD4+ T cells during immunization with nonviable Listeria monocytogenes causes enhanced CD8+ T cell-mediated protection against listeriosis
Kursar M, Köhler A, Kaufmann S, Mittrücker H
J IMMUNOL. 2004;172(5):3167-72.

Protective T cell response against intracellular pathogens in the absence of Toll-like receptor signaling via myeloid differentiation factor 88
Kursar M, Mittrücker H, Koch M, Köhler A, Herma M, Kaufmann S
INT IMMUNOL. 2004;16(3):415-21.

Enhanced TCR-induced apoptosis in interferon regulatory factor 4-deficient CD4(+) Th cells
Lohoff M, Mittrücker H, Brüstle A, Sommer F, Casper B, Huber M, Ferrick D, Duncan G, Mak T
J EXP MED. 2004;200(2):247-53.

Anxiety and depression in patients with pulmonary hypertension.
Löwe B, Gräfe K, Ufer C, Kroenke K, Grünig E, Herzog W, Borst M
PSYCHOSOM MED. 2004;66(6):831-836.

Diagnosing ICD-10 depressive episodes: superior criterion validity of the Patient Health Questionnaire.
Löwe B, Gräfe K, Zipfel S, Witte S, Loerch B, Herzog W
PSYCHOTHER PSYCHOSOM. 2004;73(6):386-390.

Measuring depression outcome with a brief self-report instrument: sensitivity to change of the Patient Health Questionnaire (PHQ-9).
Löwe B, Kroenke K, Herzog W, Gräfe K
J AFFECT DISORDERS. 2004;81(1):61-66.

Comparative validity of three screening questionnaires for DSM-IV depressive disorders and physicians' diagnoses.
Löwe B, Spitzer R, Gräfe K, Kroenke K, Quenter A, Zipfel S, Buchholz C, Witte S, Herzog W
J AFFECT DISORDERS. 2004;78(2):131-140.

Mini-review
Mittrücker H, Kaufmann S
EUR J IMMUNOL. 2004;34(2):306-12.

Identification of Salmonella typhimurium genes responsible for interference with peptide presentation on MHC class I molecules
Qimron U, Madar N, Mittrücker H, Zilka A, Yosef I, Bloushtain N, Kaufmann S, Rosenshine I, Apte R, Porgador A
CELL MICROBIOL. 2004;6(11):1057-70.

Predictors of psychiatric comorbidity in medical outpatients.
Löwe B, Gräfe K, Kroenke K, Zipfel S, Quenter A, Wild B, Fiehn C, Herzog W
PSYCHOSOM MED. 2003;65(5):764-770.

Detecting panic disorder in medical and psychosomatic outpatients: comparative validation of the Hospital Anxiety and Depression Scale, the Patient Health Questionnaire, a screening question, and physicians' diagnosis.
Löwe B, Gräfe K, Zipfel S, Spitzer R, Herrmann-Lingen C, Witte S, Herzog W
J PSYCHOSOM RES. 2003;55(6):515-519.

Expression of the B7-related molecule ICOSL by human glioma cells in vitro and in vivo
Schreiner B, Wischhusen J, Mitsdoerffer M, Schneider D, Bornemann A, Melms A, Tolosa E, Weller M, Wiendl H
GLIA. 2003;44(3):296-301.

Cathepsin V is involved in the degradation of invariant chain in human thymus and is overexpressed in myasthenia gravis
Tolosa E, Li W, Yasuda Y, Wienhold W, Denzin L, Lautwein A, Driessen C, Schnorrer P, Weber E, Stevanovic S, Kurek R, Melms A, Bromme D
J CLIN INVEST. 2003;112(4):517-26.

Antigen processing and presentation in human muscle
Wiendl H, Lautwein A, Mitsdörffer M, Krause S, Erfurth S, Wienhold W, Morgalla M, Weber E, Overkleeft H, Lochmüller H, Melms A, Tolosa E, Driessen C
J NEUROIMMUNOL. 2003;138(1-2):132-43.

The CD28 related molecule ICOS
Wiendl H, Neuhaus O, Mehling M, Wintterle S, Schreiner B, Mitsdoerffer M, Wienhold W, Weissert R, Wessels J, Hartung H, Weller M, Tolosa E, Melms A
J NEUROIMMUNOL. 2003;140(1-2):177-87.

Macrophage migration inhibitory factor (MIF) plays a pivotal role in immunity against Salmonella typhimurium
Koebernick H, Grode L, David J, Rohde W, Rolph M, Mittrücker H, Kaufmann S
P NATL ACAD SCI USA. 2002;99(21):13681-6.

Regulatory CD4+CD25+ T cells restrict memory CD8+ T cell responses
Kursar M, Bonhagen K, Fensterle J, Köhler A, Hurwitz R, Kamradt T, Kaufmann S, Mittrücker H
J EXP MED. 2002;196(12):1585-92.

Organ-specific CD4+ T cell response during Listeria monocytogenes infection
Kursar M, Bonhagen K, Köhler A, Kamradt T, Kaufmann S, Mittrücker H
J IMMUNOL. 2002;168(12):6382-7.

Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4
Lohoff M, Mittrücker H, Prechtl S, Bischof S, Sommer F, Kock S, Ferrick D, Duncan G, Gessner A, Mak T
P NATL ACAD SCI USA. 2002;99(18):11808-12.

Characterization of the murine T-lymphocyte response to Salmonella enterica serovar Typhimurium infection
Mittrücker H, Köhler A, Kaufmann S
INFECT IMMUN. 2002;70(1):199-203.

Inducible costimulator protein controls the protective T cell response against Listeria monocytogenes
Mittrücker H, Kursar M, Köhler A, Yanagihara D, Yoshinaga S, Kaufmann S
J IMMUNOL. 2002;169(10):5813-7.

Role of CD28 for the generation and expansion of antigen-specific CD8(+) T lymphocytes during infection with Listeria monocytogenes
Mittrücker H, Kursar M, Köhler A, Hurwitz R, Kaufmann S
J IMMUNOL. 2001;167(10):5620-7.

Deficiency in the transcription factor interferon regulatory factor (IRF)-2 leads to severely compromised development of natural killer and T helper type 1 cells
Lohoff M, Duncan G, Ferrick D, Mittrücker H, Bischof S, Prechtl S, Röllinghoff M, Schmitt E, Pahl A, Mak T
J EXP MED. 2000;192(3):325-36.

Immune response to infection with Salmonella typhimurium in mice
Mittrücker H, Kaufmann S
J LEUKOCYTE BIOL. 2000;67(4):457-63.

Substantial in vivo proliferation of CD4(+) and CD8(+) T lymphocytes during secondary Listeria monocytogenes infection
Mittrücker H, Köhler A, Kaufmann S
EUR J IMMUNOL. 2000;30(4):1053-9.

Cutting edge
Mittrücker H, Raupach B, Köhler A, Kaufmann S
J IMMUNOL. 2000;164(4):1648-52.

Critical role of leukocyte function-associated antigen-1 in liver accumulation of CD4+NKT cells
Emoto M, Mittrücker H, Schmits R, Mak T, Kaufmann S
J IMMUNOL. 1999;162(9):5094-8.

Genomic instability in Gadd45a-deficient mice
Hollander M, Sheikh M, Bulavin D, Lundgren K, Augeri-Henmueller L, Shehee R, Molinaro T, Kim K, Tolosa E, Ashwell J, Rosenberg M, Zhan Q, Fernández-Salguero P, Morgan W, Deng C, Fornace A
NAT GENET. 1999;23(2):176-84.

A dominant-negative mutant of c-Jun inhibits cell cycle progression during the transition of CD4(-)CD8(-) to CD4(+)CD8(+) thymocytes
King L, Tolosa E, Lenczowski J, Lu F, Lind E, Hunziker R, Petrie H, Ashwell J
INT IMMUNOL. 1999;11(8):1203-16.

Critical role of CD28 in protective immunity against Salmonella typhimurium
Mittrücker H, Köhler A, Mak T, Kaufmann S
J IMMUNOL. 1999;163(12):6769-76.

Thymus-derived glucocorticoids and the regulation of antigen-specific T-cell development
Tolosa E, Ashwell J
NEUROIMMUNOMODULAT. 1999;6(1-2):90-6.

Receptor-specific allelic exclusion of TCRV alpha-chains during development
Boyd R, Kozieradzki I, Chidgey A, Mittrücker H, Bouchard D, Timms E, Kishihara K, Ong C, Chui D, Marth J, Mak T, Penninger J
J IMMUNOL. 1998;161(4):1718-27.

Cytokine-dependent abortion in CBA x DBA/2 mice is mediated by the procoagulant fgl2 prothrombinase [correction of prothombinase]
Clark D, Chaouat G, Arck P, Mittrücker H, Levy G
J IMMUNOL. 1998;160(2):545-9.

Thymocyte glucocorticoid resistance alters positive selection and inhibits autoimmunity and lymphoproliferative disease in MRL-lpr/lpr mice
Tolosa E, King L, Ashwell J
IMMUNITY. 1998;8(1):67-76.

Triptolide induces apoptotic death of T lymphocyte
Yang Y, Liu Z, Tolosa E, Yang J, Li L
Immunopharmacology. 1998;40(2):139-49.

Interferon regulatory factor-1 is required for a T helper 1 immune response in vivo
Lohoff M, Ferrick D, Mittrucker H, Duncan G, Bischof S, Rollinghoff M, Mak T
IMMUNITY. 1997;6(6):681-9.

Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function
Mittrücker H, Matsuyama T, Grossman A, Kündig T, Potter J, Shahinian A, Wakeham A, Patterson B, Ohashi P, Mak T
SCIENCE. 1997;275(5299):540-3.

The interferon regulatory transcription factor IRF-1 controls positive and negative selection of CD8+ thymocytes
Penninger J, Sirard C, Mittrücker H, Chidgey A, Kozieradzki I, Nghiem M, Hakem A, Kimura T, Timms E, Boyd R, Taniguchi T, Matsuyama T, Mak T
IMMUNITY. 1997;7(2):243-54.

Hyperexpression of transporter in antigen processing-1 (TAP-1) in thyroid glands affected by autoimmunity
Sospedra M, Tolosa E, Armengol P, Ashhab Y, Urlinger S, Lucas-Martin A, Foz-Sala M, Jaraquemada D, Pujol-Borrell R
CLIN EXP IMMUNOL. 1997;109(1):98-106.

CD2-mediated signaling in T cells lacking the zeta-chain-specific immune receptor tyrosine-based activation (ITAM) motif
Steeg C, von Bonin A, Mittrücker H, Malissen B, Fleischer B
EUR J IMMUNOL. 1997;27(9):2233-8.

The T-cell receptor associated zeta-chain is required but not sufficient for CD26 (dipeptidylpeptidase IV) mediated signaling
von Bonin A, Steeg C, Mittrücker H, Fleischer B
IMMUNOL LETT. 1997;55(3):179-82.

Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice
Amakawa R, Hakem A, Kundig T, Matsuyama T, Simard J, Timms E, Wakeham A, Mittrücker H, Griesser H, Takimoto H, Schmits R, Shahinian A, Ohashi P, Penninger J, Mak T, Mittrücker H
CELL. 1996;84(4):551-62.

The transcription factor interferon regulatory factor-1 is essential for natural killer cell function in vivo
Duncan G, Mittrücker H, Kägi D, Matsuyama T, Mak T
J EXP MED. 1996;184(5):2043-8.

Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25
Grossman A, Mittrücker H, Nicholl J, Suzuki A, Chung S, Antonio L, Suggs S, Sutherland G, Siderovski D, Mak T
GENOMICS. 1996;37(2):229-33.

Duration of TCR stimulation determines costimulatory requirement of T cells
Kündig T, Shahinian A, Kawai K, Mittrücker H, Sebzda E, Bachmann M, Mak T, Ohashi P
IMMUNITY. 1996;5(1):41-52.

Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4
Marengère L, Waterhouse P, Duncan G, Mittrücker H, Feng G, Mak T
SCIENCE. 1996;272(5265):1170-3.

Induction of unresponsiveness and impaired T cell expansion by staphylococcal enterotoxin B in CD28-deficient mice
Mittrücker H, Shahinian A, Bouchard D, Kündig T, Mak T
J EXP MED. 1996;183(6):2481-8.

A fluorogenic assay of endogenous phosphatase for assessment of cell adhesion
Tolosa E, Shaw S
J IMMUNOL METHODS. 1996;192(1-2):165-72.

CTLA-4, a negative regulator of T-lymphocyte activation
Waterhouse P, Marengère L, Mittrücker H, Mak T
Immunological reviews. 1996;153:183-207.

Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE)
Matsuyama T, Grossman A, Mittrücker H, Siderovski D, Kiefer F, Kawakami T, Richardson C, Taniguchi T, Yoshinaga S, Mak T
NUCLEIC ACIDS RES. 1995;23(12):2127-36.

T-lymphocyte development and function in gene-targeted mutant mice
Mittrücker H, Pfeffer K, Schmits R, Mak T
Immunological reviews. 1995;148:115-50.

The cytoplasmic tail of the T cell receptor zeta chain is required for signaling via CD26
Mittrücker H, Steeg C, Malissen B, Fleischer B
EUR J IMMUNOL. 1995;25(1):295-7.

MSH2 deficient mice are viable and susceptible to lymphoid tumours
Reitmair A, Schmits R, Ewel A, Bapat B, Redston M, Mitri A, Waterhouse P, Mittrücker H, Wakeham A, Liu B
NAT GENET. 1995;11(1):64-70.

Hyperinducibility of HLA class II expression of thyroid follicular cells from Graves' disease. A primary defect?
Sospedra M, Obiols G, Babi L, Tolosa E, Vargas F, Roura-Mir C, Lucas-Martin A, Ercilla G, Pujol-Borrell R
J IMMUNOL. 1995;154(8):4213-22.

Characterization of neural cell adhesion molecule (NCAM) expression in thyroid follicular cells
Vargas F, Tolosa E, Sospedra M, Catálfamo M, Lucas-Martín A, Obiols G, Pujol-Borrell R
CLIN EXP IMMUNOL. 1994;98(3):478-88.

Blood B, T, CD4+ and CD8+ lymphocytes in female Wistar rats
Franch A, Castellote C, Pelegrí C, Tolosa E, Castell M
ANN HEMATOL. 1993;67(3):115-8.

Enzymatic activity of CD26 (dipeptidylpeptidase IV) is not required for its signalling function in T cells
Hegen M, Mittrücker H, Hug R, Demuth H, Neubert K, Barth A, Fleischer B
IMMUNOBIOLOGY. 1993;189(5):483-93.

Herpes virus saimiri-transformed human T lymphocytes
Mittrücker H, Müller-Fleckenstein I, Fleckenstein B, Fleischer B
INT IMMUNOL. 1993;5(8):985-90.

Prognostic impact of mutated K-ras gene in surgically resected non-small cell lung cancer patients
Rosell R, Li S, Skacel Z, Mate J, Maestre J, Canela M, Tolosa E, Armengol P, Barnadas A, Ariza A
ONCOGENE. 1993;8(9):2407-12.

Gamma delta lymphocytes in endocrine autoimmunity
Roura-Mir I, Alcalde L, Vargas F, Tolosa E, Obiols G, Foz M, Jaraquemada D, Pujol-Borrell R
CLIN EXP IMMUNOL. 1993;92(2):288-95.

Functional localization of an exocytosis-triggering G-protein in human cytotoxic T lymphocytes
Mittrücker H, Fleischer B
IMMUNOLOGY. 1992;76(4):610-5.

Stimulator cell-dependent requirement for CD2- and LFA-1-mediated adhesions in T lymphocyte activation by superantigenic toxins
Mittrücker H, Fleischer B
CELL IMMUNOL. 1992;139(1):108-17.

CD2-mediated autocrine growth of herpes virus saimiri-transformed human T lymphocytes
Mittrücker H, Müller-Fleckenstein I, Fleckenstein B, Fleischer B
J EXP MED. 1992;176(3):909-13.

Expression of intercellular adhesion molecule-1 in thyroid follicular cells in autoimmune, non-autoimmune and neoplastic diseases of the thyroid gland
Tolosa E, Roura C, Catálfamo M, Martí M, Lucas-Martín A, Sanmartí A, Salinas I, Obiols G, Foz-Sala M, Pujol-Borrell R
J AUTOIMMUN. 1992;5(1):107-18.

Induction of intercellular adhesion molecule-1 but not of lymphocyte function-associated antigen-3 in thyroid follicular cells
Tolosa E, Roura C, Martí M, Belfiore A, Pujol-Borrell R
J AUTOIMMUN. 1992;5(1):119-35.

Evidence for T cell receptor-HLA class II molecule interaction in the response to superantigenic bacterial toxins
Fleischer B, Mittrücker H
EUR J IMMUNOL. 1991;21(5):1331-3.

Mitogenic toxins as MHC class II-dependent probes for T cell antigen receptors
Fleischer B, Mittrücker H, Metzroth B, Braun M, Hartwig U
Behring Institute Mitteilungen. 1991;(88):170-6.

Selective loss of pertussis toxin-sensitive G-proteins from the plasma membrane after antibody-induced internalization of T-cell surface molecules
Gerardy-Schahn R, Mittrücker H, Schultze U, Fleischer B
J BIOL CHEM. 1991;266(11):6942-7.

Letzte Aktualisierung aus dem FIS: 17.08.2017 - 00:01 Uhr

Dissertationen

  • Isabell Yan (Dr. med.)
    Die Bedeutung von Interleukin-6 für die Immunantwort gegenListeria monocytogenes

  • Stephan Menzel (Dr. rer. nat.)
    Regulation der ADP-Ribosyltransferase ARTC2.2 durch Nukleotid-induzierte Proteolyse

    Christina Helmis (Master thesis)
    Die Regulation von T-Lymphozyten durch den Transkriptionsfaktor Interferon Regulatory Factor-4 (IRF4)

    Christina Pekar (Master thesis)
    Antenatal steroid treatment: Influence on Tcell selection and the development of the immune system

  • Kira Heesch (Dr. rer. nat.)
    Die Funktion des Chemokinrezeptors CXCR6 in der T-Zellantwort der Maus gegenListeria monozytogenes

    Stefanie Hünemörder (Dr. rer. nat.)
    Die Rolle verschiedener T Zellsubpopulationen in der Experimentellen Autoimmunen Glumerulonephritis der Maus

    Anne Rissiek (Dr. rer. nat.)
    A single nucleotide polymorphism in the ENTPD1 gene determines CD39 expression levels in regulatory T cells and impinges on their function

    Friedericke Raczkowski (Dr. rer. nat.)
    Interferon Regulatory Factor 4 ist ein Schlüsselregulatory der Differenzierung von peripheren CD8 T Zellen

    Michael Schneider (Dr. med.)
    Die Rolle von CD38 in intestinalen Entzündungen

    Vivien Thom (Dr. med.)
    The role of inflammatory cells in postischemic inflammation: From mice to men

    Andrea Mautner (Master thesis)
    Regulation of inflammatiory millieu through the ATP/adenosine axis

    Karsten Lücke (Master Thesis)
    Role of the interleukin 6 in the immune response of the mouse

    Malte Klüssendorf (Master Thesis)
    Analyse und Modifikation der Expression des Interferon Regulatory Factor 4 in humanen T-Lymphozyten

  • Mandy Unger (Dr. rer. nat.)
    Klonierung und molekulare Charakterisierung von Einzeldomänenantikörpern gegen das membranständige ecto-Enzym CD38 aus Homo sapiens und gegen Toxine ausChlostridium difficile

    Björn Rissiek (Dr. rer. nat.)
    Untersuchung des Einflusses von extrazellulärem Nikotinamidadenindinukleotid (NAD+) auf regulatorische T Zellen der Maus (Mus musculus, Linnaeus, 1758)

    Welbeck Danquah (Dr. rer. nat.)
    Selection and characterization of llama-derived single domain antibodies

    Julia Holzer (Dr. rer. nat.)
    Charakterisierung der T Zell Antwort in der experimentellen autoimmunen Glomerulonephritis der Maus

    Judith Hoge (Dr. med.)
    Die Bedeutung des Trans-Signalweges von Interleukin-6 für die angeborene Immunantwort auf Listeria monocytogenes

    Matthias Schafferus (Dr. med)
    Die Rolle von regulatorischen T-Zellen in der Immunantwort gegen intrazelluläre Bakterien: Analysen im DEREG-Mausmodell

    Birte Carstensen (Bachelor Thesis)
    Die Rolle von CD39 in der Immunantwort der Maus gegen Listeria monocytogenes

  • Janusz Wesolowski (Dr. rer. nat.)
    Klonierung des Lama glama Schwereketten-Antikörper Genlokus und Herstellung von Konstrukten für Lama Antikörper produzierende transgene Mäuse

    Philine Pfeiffer (Dipl. Biochem.)
    Molekulare Charakterisierung des Ekto-Enzyms CD38 und des Purinrezeptors P2X4 als Zielstrukturen für Einzeldomänenantikörper und für die Ekto-ADP-Ribosyltransferase ARTC2

    Merete Bock (Dr. med.)
    Die Rolle des Purinrezeptors P2X7 bei der Regulation von T-Zellen

    Sina Möller (Dr. med.)
    Einsatz von Antikörpern aus Gene-Gun Immunisierungen zur Charakterisierung von membranständigen P2X Purinorezeptoren

    Caroline Jung (Dr. med.)
    Einsatz von Antikörpern aus Gene-Gun Immunisierungen zur Charakterisierung von membranständigen Ekto-Nukleotid-Triphosphat-Diphosphohydrolasen (ENTPDs) und Ekto-Nukleotid-Pyrophosphatasen/Phosphodiesterasen (ENPPs)

  • Sabrina Laing (Dr. rer. nat.)
    Die strukturelle und funktionelle Charakterisierung der ADP-Ribosylierung von humanem Tumor-Nekrose-Faktor durch ADP-Ribosyltransferase-1

    Tanja Schoknecht (Dipl. Biochem.)
    Untersuch der murinem P2X4 und P2X7 Purinrezeptoren mit monoklonalen Antikörpern, die durch genetische Immunisierung generiert wurden

    Denise Orozco (Dipl. Biochem.)
    Induction of the Th1/Th17 axis through stimulation of innate receptors on antigen-presenting cells

  • Nicole Schwarz (Dr. rer. nat.)
    Aktivierung des P2X7-Purinrezeptors durch kovalent und nicht-kovalent gebundene Liganden

    Alexander Hann (Dr. med.)
    Die posttranslationale Proteinmodifikation des IL-2 Rezeptors durch ADP-Ribose

    Welbeck Danquah (Dipl. Biochem.)
    Construction of molecular assembly vaccines on the basis of lumazine synthase from Brucella abortus

    Julia Holzer (M.Sc.)
    Entwicklung eines autoreaktiven monoklonalen Antikörpers gegen alpha3(IV)NC1

    Kira Heesch (M.Sc.)
    Die Rolle des Chemokinrezeptors CXCR3 in der Immunantwort gegen L. monozytogenes

    Friederike Raczkowski (Dipl. Biochem.)
    Die Rolle des Chemokinrezeptors CXCR3 in der Immunantwort gegen L. monozytogenes

    Stephan Menzel (Dipl. Biochem.)
    Rekombinante Produktion, Aufreinigung und Charakterisierung pro- und eukaryotischer ADP-Ribosyl-Hydrolasen (ARHs)s

  • Jan Reyelt (Dr. rer. nat.) Isolierung und Charakterisierung von inhibitorischen Einzeldomänen-Antikörpern aus dem Lama (Lama glama L.) gegen die T-Zell-Ekto-ADP-ribosyltransferase 2.2 der Maus (Mus musculus L.)

    Peter Bannas (Dr. med.)
    Die murine T-Zell Ecto-ADP-Ribosyltransferase ART2.2: Nachweis ihrer Lokalisation in Lipid Rafts und Identifizierung ihrer Zielproteine

    Stefan Kernstock (Dr. rer. nat.)
    In silico Analysen, rekombinante Expression und Struktur-Funktionsanalysen humaner ADP-Ribosyl-X-Hydrolasen

    Anette Braß (Dr. rer. nat.)
    Bedeutung des P2X7 Purinorezeptors und von Ecto-ADP-Ribosyltransferasen (ARTs) für die Reifung und Funktion von antigenpräsentierenden Zellen der Maus (Mus musculus L.)

    Cindy Hempp (Dipl. Biol.)
    Identifizierung und Charakterisierung von humanen Autoantigenen

  • Wolfgang Koestner (Dr. med.)
    Identifizierung und molekulare Charakterisierung von Zielproteinen von Mono-ADP-Ribosyltransferasen (ARTs)

    Claudia Bechstedt (Dr. med.)
    Nukleotide im Immunsystem - Untersuchung zur Bedeutung von ATP und NAD für die Lymphozytenfunktion anhand einer natürlich vorkommenden Mutation im murinen Purinozeptor P2X7

    Kristina Burkert (B.Sc. Biotechnology)
    Cloning and Production of enzyme- inhibiting single-chain Antibodies from Lama glama

  • Felix Scheuplein (Dr. rer. nat.)
    Molekulare Mechanismen und Funktion der durch die ADP-Ribosyltransferase ART2 vermittelten Apoptose muriner T-Zellen

    Wolfgang Koestner (Dr. med.)
    Molekulare Charakterisierung von Zielproteinen der Zelloberflächen ADP-Ribosylierung

    Ines Parusel (Dr. med.)
    Analyse der Expression und Aktivität von membranständigen ADP-Ribosyltransferasen im humanen Immunsystem

    Alexandra Höfs (Dr. med.)
    Molekulare Charakterisierung neuer Protein-ADP-Ribosylhydrolasen

  • Dietmar Kühn (Dr. med.)
    Gewinnung, Aufreinigung und Charakterisierung von polyklonalen Antiseren aus Kaninchen und Ente gegen rekombinante Fusionsproteine aus ß-Galaktosidase und RT6

    Phillip Diessenbacher (Dr. med.)
    Molekulare Charakterisierung des für das T-Zell Überleben essentiellen Transkriptionsfaktors LKLF

    Christian Krebs (Dr. med.)
    Immunoassays für ADP-Ribosylierungen von Zelloberflächenproteinen

    Helge Otto (Dr.med.)
    Molekulare Charakterisierung neuer humaner Poly-ADP-Ribosyltransferasen und der SpvB mono-ADP-Ribosyltransferase von Salmonellen

  • Stefan Kernstock (Dipl.Biochem.)
    Klonierung und molekulare Charakterisierung neuer putativer ADP-Ribosylhydrolasen von Mensch und Maus

    Katrin Firner (Ärztin)
    Molekulare Charakterisierung der murinen ecto-ADP-Ribosyltransferase ART4

    Thorsten Lieke (cand. rer. nat.)
    Beteiligung von murinen Natürlichen Killer (NK)-Zellen an der Immunantwort gegen intrazelluläre und extrazelluläre Trypanosoma cruzi (Trypanosomatidae, Kinetoplastida)

  • Stefan Rothenburg (Dr.med.)
    Identifizierung von cis-regulatorisch wirksamen Differenzen zwischen den Allelen des RT6 Gens

    Sarah Kahl (Dr.med.)
    Charakterisierung von ADP-Ribosyltransferasen mithilfe von durch 'gene-gun' Immunisierungen generierten Antiseren und monoklonalen Antikörpern

    Britta Schössow (Dipl.Biol.)
    Diplomarbeit: Herstellung und Charakterisierung von ADP-Ribosyltransferase-spezifischen Antikörpern in Lamas (Lama glama)

  • Wiebke Ohlrogge (Dr. rer. nat.)
    ADP-Ribosyltransferasen (ARTs) und Immunfunktionen: Folgen von ART-Gendefekten für Immunfunktionen

    Kay Bredehorst (Dr. med.)
    Zielgerichtete Mutagenese der ADP-Ribosyltransferasen Rt6.1/RT6.2: Identifizierung der für die Katalyse essentiellen Aminosäuren

    Rickmer Braren (Dr. med.)
    Klonierung, Charakterisierung und Inaktivierung humaner und muriner Ekto-Mono(ADP-Ribosyl)transferasen

  • Jens Siveke (Dr. med.)
    T-Helferzellen vom Th1/Th2-Typ: Chemokin-induzierte Chemotaxis und Chemokin-rezeptor-Expression

    Gustavo Glowacki (Dr. rer. nat.)
    Molekulare Klonierung und Charakterisierung neuer muriner Mono-ADP-Ribosyltransferasen

    Karsten Wursthorn (Dr. med.)
    Rekombinante Herstellung der Mono-ADP-Ribosyltransferase RT6 im E.coli Expressionssystem

    Dominik Kahlke (Dr. med.)
    Expression rekombinanter Formen des Ratten- und Maus- TZell Differenzierungsmarkers RT6/Rt6 in eukaryontischen und prokaryontischen Systemen, Analyse seiner Enzymfunktionen und Untersuchung endogener ADP-Ribosyltransferaseaktivitäten auf lymphatischen T-Zelllinien der Maus

    Jens Schröder (Dr. med.)
    Rekombinanter Herstellung des T-Zell Differenzierungsmarkers RT6 und Charakterisierung seiner

    Andreas Gerber (Dr. med.)
    Arts in Artfreien Zellen oder: Expression von mono(ADP-ribosyl)transferasen in EL4-Zellen und Darstellung der Effekte der ADP-ribosylierung auf Oberflächenproteine und Zellaggregation

  • Stefan Karsten (Dr. med.)
    "Expression rekombinanter Formen des Ratten T-Zell Differenzierungsmarkers RT6 in eukaryontischen und prokaryontischen Systemen, und Analyse seiner ADP-Ribosyltransferase-Aktivität

    Jing Fang (Dr. med.)
    Regulation der Genexpression des Ratten T-Zell Differenzierungsmarkers RT6

  • Gesina Phillipi (Dr. med.)
    Messung der Zytokin-mRNA in RT6-positiven und -negativen T-Zellpopulationen der Ratte

    Viola Andresen (Dr. med.)
    Der T-Zell Differenzierungsmarkers RT6: ein lymphozytäres Oberflächenenzym aus der Familie der ADP-Ribosyltransferasen

  • Martin Schlott (Dr. med.)
    Immunodetektion und Charakterisierung der murinen Mono(ADP-Ribosyl)transferase mRt6

    Volker Grosse (Dr. med.)
    Rekombinante Expresion des T-Zell Differenzierungsmarkers RT6 auf der Zelloberfläche von COS-Zellen

    Wolfgang Tietz (Dr. rer. nat.)

  • Martina Matthes (Dr. rer. nat.)
    Gezielte Elimination der beiden Rt6 Gene der Maus durch homologe Rekombination

    Andre Damaske (Dr. med.)
    Expression der murinen und menschlichen Homologen des T-Zell Differenzierungsmarkers RT6 als rekombinante Fusionsproteine im prokaryontischen System und seine Verwendung für Immunisierungen und Charakterisierungen von Antiseren

    Gregor Kuhlenbäumer (Dr. med.)
    Semiquantitative mRNA Genexpressionsanalysen der NAD-(Mono)-ADP-Ribosyltransferase Rt6

    Thomas Willer (Dr. med.)
    Nachweis und Charakterisierung des Rt6 der Maus in Überständen PI-PLC-behandelter Zellen mit epitopselektionierten Antikörpern

    Heinrich Bertuleit (Dr. med.)
    Semiquantitative mRNA Genexpressionsanalysen der NAD-(Mono)-ADP-Ribosyltransferase Rt6

  • Dr. Friedrich Haag (Priv. Doz.)
    Der T-Zell-Differenzierungsmarker RT6: ein polymorphes System GPI-verankerter Oberflächenenzyme mit Verwandtschaft zu bakteriellen ADP-ribosylierenden Toxinen

    Johannes Klein (Dr. med.)
    Vergleichende mRNA Expressionsanalysen eines in der Entstehung von Autoimmunität potentiell bedeutsamen T-Zellmarkers in einem Mausmodellsystem für den systemischen Lupus Erythematodes

    Christiane Hollmann (Dr. rer. nat.)
    Molekulare Klonierung und Charakterisierung der RT6-homologen Gene der Maus