AG Saugel

Prof. Dr. med. Bernd Saugel
Clinic/Institute: Department of Anesthesiology, Center of Anesthesiology & Intensive Care Medicine
Phone: +49 (0) 40 7410 - 18866

Research Focus and Main research questions

Our research focus is the hemodynamic management of patients having major surgery and of critically ill patients. The superordinated goal of our research is to improve patient-centered outcomes in perioperative and intensive care medicine. We specifically focus on concepts of "personalized hemodynamic management" (Saugel B, et al. Curr Opin Crit Care. 2017. 23:334-341) using advanced innovative hemodynamic monitoring methods. We develop and investigate strategies to optimize blood pressure, blood flow, oxygen delivery, and microcirculatory perfusion in surgical patients before, during, and after surgery and in critically ill patients treated in the intensive care unit.

  • Methods
  • Methods


    • Clinical (multicenter) randomized-controlled trials in perioperative and intensive care medicine
    • Innovative hemodynamic monitoring methods to measure blood pressure, blood flow, oxygen delivery, and microcirculatory perfusion

  • Publications:

    1. Fortin J, Rogge D, Fellner C, Flotzinger D, Grond J, Lerche K, Saugel B: A novel art of continuous noninvasive blood pressure measurement. Nat Commun 2021; 12:1387.

    2. Saugel B, Sessler DI: Perioperative Blood Pressure Management. Anesthesiology 2021; 134:250-261.

    3. Schumann R, Meidert AS, Bonney I, Koutentis C, Wesselink W, Kouz K, Saugel B: Intraoperative Blood Pressure Monitoring in Obese Patients. Anesthesiology 2021; 134:179-188.

    4. Nicklas JY, Diener O, Leistenschneider M, Sellhorn C, Schon G, Winkler M, Daum G, Schwedhelm E, Schroder J, Fisch M, Schmalfeldt B, Izbicki JR, Bauer M, Coldewey SM, Reuter DA, Saugel B: Personalised haemodynamic management targeting baseline cardiac index in high-risk patients undergoing major abdominal surgery: a randomised single-centre clinical trial. Br J Anaesth 2020; 125:122-132.

    5. Saugel B, Reese PC, Sessler DI, Burfeindt C, Nicklas JY, Pinnschmidt HO, Reuter DA, Sudfeld S: Automated Ambulatory Blood Pressure Measurements and Intraoperative Hypotension in Patients Having Noncardiac Surgery with General Anesthesia: A Prospective Observational Study. Anesthesiology 2019; 131:74-83.

    6. Saugel B, Grothe O, Nicklas JY: Error Grid Analysis for Arterial Pressure Method Comparison Studies. Anesth Analg 2018; 126:1177-1185.

    7. Sudfeld S, Brechnitz S, Wagner JY, Reese PC, Pinnschmidt HO, Reuter DA, Saugel B: Post-induction hypotension and early intraoperative hypotension associated with general anaesthesia. Br J Anaesth 2017; 119:57-64.

    8. Saugel B, Vincent JL, Wagner JY: Personalized hemodynamic management. Curr Opin Crit Care 2017; 23:334-341.

  • Recent Funding:

    • The effect of intraoperative cardiac output-guided goal-directed hemodynamic therapy on perioperative oxygen delivery and consumption as well as microcirculatory perfusion in comparison to routine hemodynamic management.
    Werner Otto Stiftung (Hamburg, Germany)

    • Impact of perioperative personalized blood pressure management on postoperative complications and mortality in high-risk patients having major surgery: a multicenter prospective randomized controlled interventional clinical study (IMPROVE-multi).
    Deutsche Gesellschaft für Anästhesiologie und lntensivmedizin (DGAI; Nürnberg, Germany)

    • Personalized perioperative blood pressure management.
    Else Kröner-Fresenius-Stiftung (Bad Homburg, Germany)

    • Continuous and non-invasive determination of blood pressure and cardiac output: a triple comparison in clinical practice.
    CNSystems Medizintechnik GmbH (Graz, Austria)

    • Cardiac output estimation using "long time interval analysis”. Retia Medical (Valhalla, NY, USA) • Individualized perioperative hemodynamic goal-directed therapy in major abdominal surgery (iPEGASUS-trial): a multi-center, prospective, randomized trial.
    Pulsion Medical Systems (Feldkirchen, Germany)

Research Team