Boris Fehse
Prof. Dr. rer. nat. Dipl.-Med.
Boris Fehse
  • 1.Arbeitsbereich
Sprachen
Deutsch (Muttersprache)
Russisch
Englisch

Fachgebiete

Tätigkeitsschwerpunkte

Publikationen

2017

Cetuximab resistance in head and neck cancer is mediated by EGFR-K521 polymorphism
Braig F, Kriegs M, Habel B, Voigtländer M, Grob T, Biskup K, Blanchard V, Sack M, Thalhammer A, Ben Batalla I, Braren I, Laban S, Danielczyk A, Goletz S, Jakubowicz E, Märkl B, Trepel M, Knecht R, Riecken K, Fehse B, Loges S, Bokemeyer C, Binder M
CANCER RES. 2017;77(5):1188–1199.

Impact of Molecular Genetics on Outcome in Myelofibrosis Patients after Allogeneic Stem Cell Transplantation
Kröger N, Panagiota V, Badbaran A, Zabelina T, Triviai I, Araujo Cruz M, Shahswar R, Ayuketang F, Gehlhaar M, Wolschke C, Bollin R, Walter C, Dugas M, Wiehlmann L, Lehmann U, Koenecke C, Chaturvedi A, Alchalby H, Stadler M, Eder M, Christopeit M, Göhring G, Koenigsmann M, Schlegelberger B, Kreipe H, Ganser A, Stocking C, Fehse B, Thol F, Heuser M
BIOL BLOOD MARROW TR. 2017 [Epub ahead of print].

Optical Barcoding for Single-Clone Tracking to Study Tumor Heterogeneity
Mohme M, Maire C, Riecken K, Zapf S, Aranyossy T, Westphal M, Lamszus K, Fehse B
MOL THER. 2017;25(3):621-633.

ГЕННАЯ КЛЕТОЧНАЯ ТЕРАПИЯ ВИЧ И ЗЛОКАЧЕСТВЕННЫХ ОПУХОЛЕЙ КРОВЕТВОРНОЙ И ЛИМФАТИЧЕСКОЙ ТКАНИ НА ОСНОВЕ ТРАНСПЛАНТАЦИИ ГЕМОПОЭТИЧЕСКИХ СТВОЛОВЫХ КЛЕТОК С ИСПОЛЬЗОВАНИЕМ САЙТ-СПЕЦИФИЧЕСКОГО РЕДАКТИРОВАНИЯ ГЕНОМА
Popova M, Sergeev V, Lepik K, Shakirova A, Potter A, Barkhatov I, Fehse B, Afanasyev B
Zhurnal infektologii. 2017;9(1):31-39.

IL-33-Mediated Expansion of Type 2 Innate Lymphoid Cells Protects from Progressive Glomerulosclerosis
Riedel J, Becker M, Kopp K, Düster M, Brix S, Meyer-Schwesinger C, Kluth L, Gnirck A, Attar M, Krohn S, Fehse B, Stahl R, Panzer U, Turner J
J AM SOC NEPHROL. 2017 [Epub ahead of print].

Limitations and challenges of genetic barcode quantification
Thielecke L, Aranyossy T, Dahl A, Tiwari R, Roeder I, Geiger H, Fehse B, Glauche I, Cornils K
SCI REP-UK. 2017;7:43249.

2016

Mesenchymal Stromal/Stem Cells Do Not Ameliorate Experimental Autoimmune Encephalomyelitis and Are Not Detectable in the Central Nervous System of Transplanted Mice
Abramowski P, Krasemann S, Ernst T, Lange C, Ittrich H, Schweizer M, Zander A, Martin R, Fehse B
STEM CELLS DEV. 2016;25(15):1134-48.

Digital-PCR assay for screening and quantitative monitoring of calreticulin (CALR) type-2 positive patients with myelofibrosis following allogeneic stem cell transplantation
Badbaran A, Fehse B, Christopeit M, Aranyossy T, Ayuketang F, Wolschke C, Kröger N
BONE MARROW TRANSPL. 2016;51(6):872-3.

Primary Human Hepatocytes Repopulate Livers of Mice After In Vitro Culturing and Lentiviral-Mediated Gene Transfer
Bierwolf J, Volz T, Lütgehetmann M, Allweiss L, Riecken K, Warlich M, Fehse B, Kalff J, Dandri-Petersen M, Pollok J
TISSUE ENG. 2016;22(9-10):742-53.

Investigation of the Mesenchymal Stem Cell Compartment by Means of a Lentiviral Barcode Library
Bigildeev A, Cornils K, Aranyossy T, Sats N, Petinati N, Shipounova I, Surin V, Pshenichnikova O, Riecken K, Fehse B, Drize N
BIOCHEMISTRY (MOSC). 2016;81(4):373-81.

Similar outcome of calreticulin type I and calreticulin type II mutations following RIC allogeneic haematopoietic stem cell transplantation for myelofibrosis
Christopeit M, Badbaran A, Zabelina T, Zeck G, Fehse B, Ayuketang F, Wolschke C, Kröger N
BONE MARROW TRANSPL. 2016;51(10):1391-1393.

Microglia regulate hippocampal neurogenesis during chronic neurodegeneration
De Lucia C, Rinchon A, Olmos-Alonso A, Riecken K, Fehse B, Boche D, Perry V, Gomez-Nicola D
BRAIN BEHAV IMMUN. 2016;55:179-190.

Lentiviral HSV-Tk.007-mediated suicide gene therapy is not toxic for normal brain cells
Hossain J, Ystaas L, Mrdalj J, Välk K, Riecken K, Fehse B, Bjerkvig R, Grønli J, Miletic H
J GENE MED. 2016;18(9):234-43.

Alpharetroviral self-inactivating vectors produced by a superinfection-resistant stable packaging cell line allow genetic modification of primary human T lymphocytes
Labenski V, Suerth J, Barczak E, Heckl D, Levy C, Bernadin O, Charpentier E, Williams D, Fehse B, Verhoeyen E, Schambach A
BIOMATERIALS. 2016;97:97-109.

Генная терапия на основе трансплантации гемопоэтичеcких стволовых клеток с использованием сайт-специфического редактирования генома
Lepik K, Popova M, Shakirova A, Sergeev V, Potter A, Barkhatov I, Fehse B, Afanasyev B
Genes & cells (гены & клетки) . 2016;XI(2):21-29.

Long-term in vivo single-cell tracking reveals the switch of migration patterns in adult-born juxtaglomerular cells of the mouse olfactory bulb
Liang Y, Li K, Riecken K, Maslyukov A, Gomez-Nicola D, Kovalchuk Y, Fehse B, Garaschuk O
CELL RES. 2016;26(7):805-21.

Digital PCR to assess gene-editing frequencies (GEF-dPCR) mediated by designer nucleases
Mock U, Hauber I, Fehse B
NAT PROTOC. 2016;11(3):598-615.

Potent in vitro and in vivo effects of polyclonal anti-human-myeloma globulins
Schieferdecker A, Shoshani O, Westner B, Zipori D, Fehse B, Kröger N, Ayuketang F
ONCOTARGET. 2016;7(41):67061-67070.

Massive Clonal Selection and Transiently Contributing Clones During Expansion of Mesenchymal Stem Cell Cultures Revealed by Lentiviral RGB-Barcode Technology
Selich A, Daudert J, Hass R, Philipp F, von Kaisenberg C, Paul G, Cornils K, Fehse B, Rittinghausen S, Schambach A, Rothe M
STEM CELL TRANSL MED. 2016;5(5):591-601.

Digital PCR Panel for Sensitive Hematopoietic Chimerism Quantification after Allogeneic Stem Cell Transplantation
Stahl T, Rothe C, Böhme M, Kohl A, Kröger N, Fehse B
INT J MOL SCI. 2016;17(9):E1515.

2015

Combined Application of RGB Marking and Mass Spectrometric Imaging Facilitates Detection of Tumor Heterogeneity
Abramowski P, Kraus O, Rohn S, Riecken K, Fehse B, Schlüter H
Cancer Genomics & Proteomics. 2015;12(4):179-187.

Übersicht - Gentherapeutische Konzepte in der Onkologie
Abramowski P, Fehse B
Tumor Diagnostik & Therapie. 2015;36(06):333-336.

Cyclooxygenase-2 blockade can improve efficacy of VEGF-targeting drugs
Ben-Batalla I, Cubas-Cordova M, Udonta F, Wroblewski M, Waizenegger J, Janning M, Sawall S, Gensch V, Zhao L, Martinez-Zubiaurre I, Riecken K, Fehse B, Pantel K, Bokemeyer C, Loges S
ONCOTARGET. 2015;6(8):6341-58.

Epidermal growth factor receptor mutation mediates cross-resistance to panitumumab and cetuximab in gastrointestinal cancer
Braig F, März M, Schieferdecker A, Schulte A, Voigt M, Stein A, Grob T, Alawi M, Indenbirken D, Kriegs M, Engel E, Vanhoefer U, Grundhoff A, Loges S, Riecken K, Fehse B, Bokemeyer C, Binder M
ONCOTARGET. 2015;6(14):12035-47.

Themenbereich somatische Gentherapie: Translationale und klinische Forschung
Fehse B, Domasch S
2015. Dritter Gentechnologiebericht: Analyse einer Hochtechnologie. Müller-Röber B, Budisa N, Diekämper J, Domasch S, Fehse B, Hampel J, Hucho F, Hümpel A, Köchy K, Marx-Stölting L, Reich J, Rheinberger H, Ropers H, Taupitz J, Walter J, Zenke M (Hrsg.). 1. Aufl. Baden Baden: Nomos, 211-308.

Genetische Manipulation: klinische Anwendung.
Fehse B, Cornils K
2015. Hämatopoetische Stammzellen. Herr W, Theobald M, Ehninger G, Einsele H, Meyer R (Hrsg.). 1. Aufl. Köln: Deutscher Ärzte-Verlag, 21-24.

Gentherapie - zurück in die Zukunft?
Fehse B
BIOspektrum. 2015;15(4):448.

Multicolor RGB Marking Allows Morphometric and Functional Analysis of Hippocampal Granule Neurons at the Single-Cell Level
Gomez-Nicola D, Riecken K, Perry V, Fehse B
HUM GENE THER. 2015;26(6):332-333.

Retroviral insertional mutagenesis in telomerase-immortalized hepatocytes identifies RIPK4 as novel tumor suppressor in human hepatocarcinogenesis
Heim D, Cornils K, Schulze K, Fehse B, Lohse A, Brümmendorf T, Wege H
ONCOGENE. 2015;34(3):385-393.

Donor choice in haploidentical stem cell transplantation: fetal microchimerism is associated with better outcome in pediatric leukemia patients
Kruchen A, Stahl T, Gieseke F, Binder T, Özcan Z, Meisel R, Kreyenberg H, Bader P, Gruhn B, Greil J, Pfeiffer M, Döring M, Handgretinger R, Fehse B, Müller I
BONE MARROW TRANSPL. 2015;50(10):1367-1370.

Impaired bone remodeling and its correction by combination therapy in a mouse model of mucopolysaccharidosis-I
Kühn S, Koehne T, Cornils K, Markmann S, Riedel C, Pestka J, Schweizer M, Baldauf C, Yorgan T, Krause M, Keller J, Neven M, Breyer S, Stücker R, Muschol N, Busse B, Braulke T, Fehse B, Amling M, Schinke T
HUM MOL GENET. 2015;24(24):7075-7086.

mRNA transfection of a novel TAL effector nuclease (TALEN) facilitates efficient knockout of HIV co-receptor CCR5
Mock U, Machowicz R, Hauber I, Horn S, Abramowski P, Berdien B, Hauber J, Fehse B
NUCLEIC ACIDS RES. 2015;43(11):5560-5571.

Gezielter CCR5-Knockout in primären T-Lymphozyten zur Verhinderung der HIV-Infektion
Mock U, Fehse B
2015;14-16.

Targeting species D adenoviruses replication to counteract the epidemic keratoconjunctivitis
Nikitenko N, Speiseder T, Groitl P, Spirin P, Prokofjeva M, Lebedev T, Rubtsov P, Lam E, Riecken K, Fehse B, Dobner T, Prassolov V
BIOCHIMIE. 2015;113:10-16.

УНИВЕРСАЛЬНАЯ МОДУЛЬНАЯ СИСТЕМА СКРИНИНГА IN VITRO ПОТЕНЦИАЛЬНЫХ ИНГИБИТОРОВ РЕПЛИКАЦИИ ВИЧ-1
Prokof'eva M, Orlova N, Gornostaeva A, Shul'gin A, Nikitenko N, Senchenko V, Lebedev T, Spirin P, Riecken K, Fehse B, Stocking C, Prasolov V
MOL BIOL (MOSK). 2015;48(2):344-8.

Digital PCR to assess hematopoietic chimerism after allogeneic stem cell transplantation
Stahl T, Böhme M, Kröger N, Fehse B
EXP HEMATOL. 2015;43(6):462-468.

Treatment of multifocal breast cancer by systemic delivery of dual-targeted adeno-associated viral vectors
Trepel M, Körbelin J, Spies E, Heckmann M, Hunger A, Fehse B, Katus H, Kleinschmidt J, Müller O, Michelfelder S
GENE THER. 2015;22(10):840-847.

CD133 marks a stem cell population that drives human Primary Myelofibrosis
Triviai I, Stübig T, Niebuhr B, Hussein K, Tsiftsoglou A, Fehse B, Stocking C, Kröger N
HAEMATOLOGICA. 2015;100(6):768-79.

Role of Growth arrest-specific gene 6-Mer axis in multiple myeloma
Waizenegger J, Ben-Batalla I, Weinhold N, Meissner T, Wroblewski M, Janning M, Riecken K, Binder M, Atanackovic D, Taipaleenmaeki H, Schewe D, Sawall S, Gensch V, Cubas-Cordova M, Seckinger A, Fiedler W, Hesse E, Kröger N, Fehse B, Hose D, Klein B, Raab M, Pantel K, Bokemeyer C, Loges S
LEUKEMIA. 2015;29(3):696-704.

2014

TALEN-mediated editing of endogenous T-cell receptors facilitates efficient reprogramming of T lymphocytes by lentiviral gene transfer
Berdien B, Mock U, Atanackovic D, Fehse B
GENE THER. 2014;21:539–548.

Multiplexing clonality: combining RGB marking and genetic barcoding
Cornils K, Thielecke L, Hüser S, Forgber M, Thomaschewski M, Kleist N, Hussein K, Riecken K, Volz T, Gerdes S, Glauche I, Dahl A, Dandri M, Roeder I, Fehse B
NUCLEIC ACIDS RES. 2014;42(7):e56.

Neural stem cell-based intraocular administration of ciliary neurotrophic factor attenuates the loss of axotomized ganglion cells in adult mice
Flachsbarth K, Kruszewski K, Jung G, Jankowiak W, Riecken K, Wagenfeld L, Richard G, Fehse B, Bartsch U
INVEST OPHTH VIS SCI. 2014;55(11):7029-7039.

Temporal dynamics of hippocampal neurogenesis in chronic neurodegeneration
Gomez-Nicola D, Suzzi S, Vargas-Caballero M, Fransen N, Al-Malki H, Cebrian-Silla A, Garcia-Verdugo J, Riecken K, Fehse B, Perry V
BRAIN. 2014;137(Pt 8):2312-28.

In-vivo RGB marking and multicolour single-cell tracking in the adult brain
Gomez-Nicola D, Riecken K, Fehse B, Perry V
SCI REP-UK. 2014;4:7520.

Selectins mediate small cell lung cancer systemic metastasis
Heidemann F, Schildt A, Schmid K, Bruns O, Riecken K, Jung C, Ittrich H, Wicklein D, Reimer R, Fehse B, Heeren J, Lüers G, Schumacher U, Heine M
PLOS ONE. 2014;9(4):e92327.

Low frequency of calreticulin mutations in MDS patients
Heuser M, Panagiota V, Koenecke C, Fehse B, Alchalby H, Badbaran A, Shahswar R, Stadler M, Eder M, Göhring G, Trummer A, Schroeder T, Kobbe G, Thiede C, Platzbecker U, Schlegelberger B, Kroeger N, Ganser A, Thol F
LEUKEMIA. 2014.

Gentherapie
Köchy K, Domasch S, Fehse B
2014. Handbuch Ethik & Recht der Forschung am Menschen. Lenk C, Duttge G, Fangerau H (Hrsg.). 1. Aufl. Berlin, Heidelberg: Springer-Verlag, 427 - 432.

Novel lentiviral vectors with mutated reverse transcriptase for mRNA delivery of TALE nucleases
Mock U, Riecken K, Berdien B, Qasim W, Chan E, Cathomen T, Fehse B
SCI REP-UK. 2014;4:6409.

Binding of hepatitis B virus to its cellular receptor alters the expression profile of genes of bile acid metabolism
Oehler N, Volz T, Bhadra O, Kah J, Allweiss L, Giersch K, Bierwolf J, Riecken K, Pollok J, Lohse A, Fehse B, Petersen J, Urban S, Lütgehetmann M, Heeren J, Dandri M
HEPATOLOGY. 2014.

Prognostic effect of calreticulin mutations in patients with myelofibrosis after allogeneic hematopoietic stem cell transplantation
Panagiota V, Thol F, Markus B, Fehse B, Alchalby H, Badbaran A, Lehmann U, Koenecke C, Shahswar R, Chaturvedi A, Stadler M, Eder M, Göhring G, Koenigsmann M, Kloos A, Trummer A, Schroeder T, Kobbe G, Thiede C, Platzbecker U, Schlegelberger B, Kreipe H, Ganser A, Kröger N, Heuser M
LEUKEMIA. 2014;28(7):1552-5.

Cancer-testis antigen MAGE-C2/CT10 induces spontaneous CD4+ and CD8+ T-cell responses in multiple myeloma patients
Reinhard H, Yousef S, Luetkens T, Fehse B, Berdien B, Kröger N, Atanackovic D
Blood cancer journal. 2014;4:e212.

Denosumab mimics the natural decoy receptor osteoprotegerin by interacting with its major binding site on RANKL
Schieferdecker A, Voigt M, Riecken K, Braig F, Schinke T, Loges S, Bokemeyer C, Fehse B, Binder M
ONCOTARGET. 2014;5(16):6647-53.

5-azacytidine promotes an inhibitory T-cell phenotype and impairs immune mediated antileukemic activity
Stübig T, Badbaran A, Luetkens T, Hildebrandt Y, Atanackovic D, Binder T, Fehse B, Kröger N
MEDIAT INFLAMM. 2014;2014:418292.

Endogenous retrovirus induces leukemia in a xenograft mouse model for primary myelofibrosis
Triviai I, Ziegler M, Bergholz U, Oler A, Stübig T, Prassolov V, Fehse B, Kozak C, Kröger N, Stocking C
P NATL ACAD SCI USA. 2014;111(23):8595 - 8600.

2013

Axl, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine crosstalk of leukemia cells with bone marrow stroma
Ben Batalla I, Schultze A, Wroblewski M, Erdmann R, Heuser M, Waizenegger J, Riecken K, Binder M, Schewe D, Sawall S, Witzke V, Cubas Cordova M, Janning M, Wellbrock J, Fehse B, Hagel C, Krauter J, Ganser A, Lorens J, Fiedler W, Carmeliet P, Pantel K, Bokemeyer C, Loges S
BLOOD. 2013;122(14):2443-52.

Influenza virus-specific TCR-transduced T cells as a model for adoptive immunotherapy
Berdien B, Reinhard H, Meyer S, Spöck S, Kröger N, Atanackovic D, Fehse B
Human vaccines & immunotherapeutics. 2013;9(6):1205-16.

Comparative clonal analysis of reconstitution kinetics after transplantation of hematopoietic stem cells gene marked with a lentiviral SIN or a γ-retroviral LTR vector
Cornils K, Bartholomae C, Thielecke L, Lange C, Arens A, Glauche I, Mock U, Riecken K, Gerdes S, von Kalle C, Schmidt M, Roeder I, Fehse B
EXP HEMATOL. 2013;41(1):28-38.e3.

Stem cell clonality -- theoretical concepts, experimental techniques, and clinical challenges
Glauche I, Bystrykh L, Eaves C, Roeder I, , Fehse B
BLOOD CELL MOL DIS. 2013;50(4):232-40.

Genetically modified neural stem cells for a local and sustained delivery of neuroprotective factors to the dystrophic mouse retina
Jung G, Sun J, Petrowitz B, Riecken K, Kruszewski K, Jankowiak W, Kunst F, Skevas C, Richard G, Fehse B, Bartsch U
STEM CELL TRANSL MED. 2013;2(12):1001-10.

Impact of high-risk cytogenetics and achievement of molecular remission on long-term freedom from disease after autologous-allogeneic tandem transplantation in patients with multiple myeloma.
Kröger N, Badbaran A, Zabelina T, Ayuketang F, Wolschke C, Alchalby H, Klyuchnikov E, Atanackovic D, Schilling G, Hansen T, Schwarz S, Heinzelmann M, Zeschke S, Bacher U, Stübig T, Fehse B, Zander A
BIOL BLOOD MARROW TR. 2013;19(3):398-404.

A new system for parallel drug screening against multiple-resistant HIV mutants based on lentiviral self-inactivating (SIN) vectors and multi-colour analyses
Prokofjeva M, Riecken K, Spirin P, Yanvarév D, Düsedau A, Ellinger B, Fehse B, Stocking C, Prassolov V
AIDS research and therapy. 2013;10(1):1.

Fucoidans as potential inhibitors of HIV-1
Prokofjeva M, Imbs T, Shevchenko N, Spirin P, Horn S, Fehse B, Zvyagintseva T, Prassolov V
MAR DRUGS. 2013;11(8):3000-14.

Production and first-in-man use of T cells engineered to express a HSVTK-CD34 sort-suicide gene
Zhan H, Gilmour K, Chan L, Farzaneh F, McNicol A, Xu J, Adams S, Fehse B, Veys P, Thrasher A, Gaspar H, Qasim W
PLOS ONE. 2013;8(10):e77106.

2012

SOCS3 promotes interleukin-17 expression of human T cells.
Kleinsteuber K, Heesch K, Schattling S, Sander-Juelch C, Mock U, Riecken K, Fehse B, Fleischer B, Jacobsen M
BLOOD. 2012;120(22):4374-4382.

Efficient lentiviral transduction and transgene expression in primary human B cells.
Mock U, Thiele R, Uhde A, Fehse B, Horn S
HUM GENE THER METHOD. 2012;23(6):408-415.

Screening of Potential HIV-1 Inhibitors/Replication Blockers Using Secure Lentiviral in Vitro System.
Prokofjeva M, Spirin P, Yanvarev D, Ivanov A, Novikov M, Stepanov O, Gottikh M, Kochetkov S, Fehse B, Stocking C, Prassolov V
Acta Naturae. 2012;3(4):55-65.

RGB marking : Vielfarbige Zellmarkierung zur klonalen Analyse
Riecken K, Thomaschewski M, Warlich M, Cornils K, Benten D, Fehse B
Laborwelt. 2012;13(1):7-9.

RGB marking with lentiviral vectors for multicolor clonal cell tracking.
Riecken K, Thomaschewski M, Benten D, Fehse B
NAT PHYS. 2012;7(5):839-849.

p65-Dependent production of interleukin-1β by osteolytic prostate cancer cells causes an induction of chemokine expression in osteoblasts.
Schulze J, Riecken K, Baranowsky A, Streichert T, Lange T, Spiro A, Albers J, Seitz S, Zustin J, Amling M, Fehse B, Schinke T
CANCER LETT. 2012;317(1):106-113.

2011

Control of bone formation by the serpentine receptor Frizzled-9.
Albers J, Schulze J, Beil F, Gebauer M, Baranowsky A, Keller J, Marshall R, Wintges K, Friedrich F, Priemel M, Schilling A, Rueger J, Cornils K, Fehse B, Streichert T, Sauter G, Jakob F, Insogna K, Pober B, Knobeloch K, Francke U, Amling M, Schinke T
J CELL BIOL. 2011;192(6):1057-1072.

Minimal residual disease diagnostics and chimerism in the post-transplant period in acute myeloid leukemia.
Bacher U, Haferlach T, Fehse B, Schnittger S, Kröger N
SCI WORLD J. 2011;11:310-319.

Functional p53 is required for effective execution of telomerase inhibition in BCR-ABL-positive CML cells.
Brassat U, Balabanov S, Bali D, Dierlamm J, Balabanov M, Hartmann U, Sirma H, Günes C, Wege H, Fehse B, Gontarewicz A, Dikomey E, Borgmann K, Brümmendorf T
EXP HEMATOL. 2011;39(1):62-66.

Gentherapie in Deutschland. Eine Einführung
Domasch S, Fehse B
2011. Gentherapie in Deutschland: Eine interdisziplinäre Bestandsaufnahme. Themenband des Gentechnologieberichts. Forum W - Wissenschaftlicher Verlag: 31-40.

Genetic Modifications – Possibilities and Limits of Gene Therapy
Fehse B
2011. Human Nature and Self Design. mentis Verlag Paderborn: 113-136.

Stand wissenschaftlicher und medizinischer Entwicklungen
Fehse B, Baum C, Schmidt M, Kalle C
2011. Gentherapie in Deutschland: Eine interdisziplinäre Bestandsaufnahme. Themenband des Gentechnologieberichts. Forum W - Wissenschaftlicher Verlag: 41-126.

Purification of CD4(+) T cells for adoptive immunotherapy after allogeneic hematopoietic stem cell transplantation.
Klyuchnikov E, Sputtek A, Slesarchuk O, Lioznov M, Stübig T, Bacher U, Amtsfeld G, Merle E, Reckhaus M, Fehse B, Wolschke C, Adjalle R, Ayuketang Ayuk F, Zander A, Kröger N
BIOL BLOOD MARROW TR. 2011;17(3):374-383.

Purification of CD4+ T cells for adoptive immunotherapy after allogeneic hematopoietic stem cell transplantation
Klyuchnikov E, Sputtek A, Slesarchuk O, Lioznov M, Stübig T, Bacher U, Amtsfeld G, Merle E, Reckhaus M, Fehse B, Wolschke C, Adjallé R, Ayuketang F, Zander A, Kröger N
BIOL BLOOD MARROW TR. 2011;17(3):374-83.

Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells
Michaelis M, Rothweiler F, Barth S, Cinatl J, van Rikxoort M, Löschmann N, Voges Y, Breitling R, von Deimling A, Rödel F, Riecken K, Fehse B, Mack E, Stiewe T, Doerr H, Speidel D, Cinatl J, Riecken K
CELL DEATH DIS. 2011;2:e243.

Retroviral insertional mutagenesis can contribute to immortalization of mature T lymphocytes.
Newrzela S, Cornils K, Heinrich T, Schläger J, Yi J, Lysenko O, Kimpel J, Fehse B, Dorothee V
MOL MED. 2011;17(11-12):1223-1232.

Cancer suicide gene therapy with TK.007: superior killing efficiency and bystander effect.
Preuß E, Muik A, Riecken K, Otte J, von Laer D, Fehse B
J MOL MED. 2011;89(11):1113-1124.

RGB marking facilitates multicolor clonal cell tracking.
Riecken K, Thomaschewski M, Warlich M, Volz T, Cornils K, Niebuhr B, Täger M, Lütgehetmann M, Pollok J, Stocking C, Dandri-Petersen M, Benten D, Fehse B
NAT MED. 2011;17(4):504-509.

Gene therapy strategies: can we eradicate HIV?
van Lunzen J, Fehse B, Hauber J
Curr HIV/AIDS Rep. 2011;8(2):78-84.

2010

Impact of JAK2V617F mutation status, allele burden, and clearance after allogeneic stem cell transplantation for myelofibrosis.
Alchalby H, Badbaran A, Zabelina T, Kobbe G, Hahn J, Wolff D, Bornhäuser M, Christian T, Baurmann H, Bethge W, Hildebrandt Y, Bacher U, Fehse B, Zander A, Kröger N
BLOOD. 2010;116(18):3572-3581.

Screening and monitoring of MPL W515L mutation with real-time PCR in patients with myelofibrosis undergoing allogeneic-SCT.
Alchalby H, Badbaran A, Bock O, Fehse B, Bacher U, Zander A, Kröger N
BONE MARROW TRANSPL. 2010;45(9):1404-1407.

Neue Wege der Stammzellforschung: Reprogrammierung von differenzierten Körperzellen
Beier H, Fehse B, Friedrich B, Götz M, Hansmann I, Hucho F, Köchy K, Müller-Röber B, Rheinberger H, Reich J, Robpers H, Schöler H, Schöne-Seifert B, Sperling K, Tanner K, Taupitz J, Wobus A
J Reprodmed Endokrinol. 2010;7:68-77.

Influence of mannose-binding lectin genotypes and serostatus in allo-SCT
Neth O, Bacher U, Das P, Zabelina T, Kabisch H, Kroeger N, Ayuketang F, Lioznov M, Waschke O, Fehse B, Thiébaut R, Haston R, Klein N, Zander A
BONE MARROW TRANSPL. 2010;45(1):13-9.

TK.007: A novel, codon-optimized HSVtk(A168H) mutant for suicide gene therapy.
Preuß E, Treschow A, Newrzela S, Brücher D, Riecken K, Felldin U, Alici E, Gahrton G, von Laer D, Dilber M, Fehse B
HUM GENE THER. 2010;21(8):929-941.

Anticancer effects of the nitric oxide-modified saquinavir derivative saquinavir-NO against multidrug-resistant cancer cells.
Rothweiler F, Michaelis M, Brauer P, Otte J, Riecken K, Fehse B, Doerr H, Wiese M, Kreuter J, Al-Abed Y, Nicoletti F, Cinatl J
NEOPLASIA. 2010;12(12):1023-1030.

Minimal residual disease diagnostics in patients with acute myeloid leukemia in the post-transplant period: comparison of peripheral blood and bone marrow analysis.
Stahl T, Badbaran A, Kröger N, Klyuchnikov E, Zabelina T, Zeschke S, Schafhausen P, Schultz W, Asenova S, Smirnova A, Wolschke C, Ayuketang Ayuk F, Zander A, Fehse B, Bacher U
LEUKEMIA LYMPHOMA. 2010;51(10):1837-1843.

Minimal residual disease diagnostics in patients with acute myeloid leukemia in the post-transplant period
Stahl T, Badbaran A, Kröger N, Klyuchnikov E, Zabelina T, Zeschke S, Schafhausen P, Schultz W, Asenova S, Smirnova A, Wolschke C, Ayuketang F, Zander A, Fehse B, Bacher U
LEUKEMIA LYMPHOMA. 2010;51(10):1837-43.

Cell and virus genetics at the roots of gene therapy, retrovirology, and hematopoietic stem cell biology: Wolfram Ostertag (1937-2010).
Stocking C, Grez M, Fehse B, von Laer D, Itoh K, Prassolov V, Nowock J, Kühlcke K, Just U, Schröder T, Klump H, Schiedlmeier B, Grassman E, Meyer J, Li Z, Schambach A, Modlich U, Kustikova O, Galla M, Jürgen B, Zander A, Baum C
HUM GENE THER. 2010;21(11):1501-1503.

Highly efficient lentiviral transduction of phenotypically and genotypically characterized endothelial progenitor cells from adult peripheral blood.
Stockschlaeder M, Shardakova O, Riecken K, Stoldt V, Fehse B, Giers G, Scharf R
BLOOD COAGUL FIBRIN. 2010;21(5):464-473.

Mammary epithelial reconstitution with gene-modified stem cells assigns roles to Stat5 in luminal alveolar cell fate decisions, differentiation, involution, and mammary tumor formation.
Vafaizadeh V, Klemmt P, Brendel C, Riecken K, Doebele C, Britt K, Grez M, Fehse B, Desriviéres S, Groner B
STEM CELLS. 2010;28(5):928-938.

Chimerism studies with quantitative real-time PCR in stem cell recipients with acute myeloid leukemia.
Wiedemann B, Klyuchnikov E, Kröger N, Zabelina T, Stahl T, Zeschke S, Badbaran A, Ayuketang Ayuk F, Alchalby H, Wolschke C, Bokemeyer C, Fehse B, Zander A, Bacher U
EXP HEMATOL. 2010;38(12):1261-1271.

2009

Quantitative monitoring of NPM1 mutations provides a valid minimal residual disease parameter following allogeneic stem cell transplantation.
Bacher U, Badbaran A, Fehse B, Zabelina T, Zander A, Kröger N
EXP HEMATOL. 2009;37(1):135-142.

Bone marrow mesenchymal stromal cells remain of recipient origin after allogeneic SCT and do not harbor the JAK2V617F mutation in patients with myelofibrosis.
Bacher U, Asenova S, Badbaran A, Zander A, Alchalby H, Fehse B, Kröger N, Lange C, Ayuketang Ayuk F
CLIN EXP MED. 2009.

Stem cell marking with promotor-deprived self-inactivating retroviral vectors does not lead to induced clonal imbalance.
Cornils K, Lange C, Schambach A, Brugman M, Nowak R, Lioznov M, Baum C, Fehse B
MOL THER. 2009;17(1):131-143.

JAK2-V617F-triggered preemptive and salvage adoptive immunotherapy with donor-lymphocyte infusion in patients with myelofibrosis after allogeneic stem cell transplantation.
Kröger N, Alchalby H, Klyuchnikov E, Badbaran A, Hildebrandt Y, Ayuketang Ayuk F, Bacher U, Bock O, Kvasnicka M, Fehse B, Zander A
BLOOD. 2009;113(8):1866-1868.

Post-transplant immunotherapy with donor-lymphocyte infusion and novel agents to upgrade partial into complete and molecular remission in allografted patients with multiple myeloma.
Kröger N, Badbaran A, Lioznov M, Schwartz S, Zeschke S, Hildebrandt Y, Ayuketang Ayuk F, Atanackovic D, Schilling G, Zabelina T, Bacher U, Klyuchnikov E, Shimoni A, Nagler A, Corradini P, Fehse B, Zander A
EXP HEMATOL. 2009;37(7):791-798.

Retroviral insertion site analysis in dominant haematopoietic clones.
Kustikova O, Modlich U, Fehse B
Methods Mol Biol. 2009;506:373-390.

Lenalidomide as salvage therapy after allo-SCT for multiple myeloma is effective and leads to an increase of activated NK (NKp44(+)) and T (HLA-DR(+)) cells.
Lioznov M, El-Cheikh J, Hoffmann F, Hildebrandt Y, Ayuketang Ayuk F, Wolschke C, Atanackovic D, Schilling G, Badbaran A, Bacher U, Fehse B, Zander A, Blaise D, Mohty M, Kröger N
BONE MARROW TRANSPL. 2009.

Concordance of assays designed for the quantification of JAK2V617F: a multicenter study.
Lippert E, Girodon F, Hammond E, Jelinek J, Reading N, Fehse B, Hanlon K, Hermans M, Richard C, Swierczek S, Ugo V, Carillo S, Harrivel V, Marzac C, Pietra D, Sobas M, Mounier M, Migeon M, Ellard S, Kröger N, Herrmann R, Prchal J, Skoda R, Hermouet S
HAEMATOLOGICA. 2009;94(1):38-45.

Reduced proliferation of CD34(+) cells from patients with acute myeloid leukemia after gene transfer of INPP5D.
Metzner A, Precht C, Fehse B, Fiedler W, Stocking C, Günther A, Mayr G, Jücker M
GENE THER. 2009;16(4):570-573.

Reversal of P-glycoprotein-mediated multidrug resistance by the murine double minute 2 antagonist nutlin-3.
Michaelis M, Rothweiler F, Klassert D, von Deimling A, Riecken K, Fehse B, Kammerer B, Doerr H, Cinatl J
CANCER RES. 2009;69(2):416-421.

Influence of mannose-binding lectin genotypes and serostatus in allo-SCT: analysis of 131 recipients and donors.
Neth O, Bacher U, Das P, Zabelina T, Kabisch H, Kröger N, Ayuketang Ayuk F, Lioznov M, Waschke O, Fehse B, Thiébaut R, Haston R, Klein N, Zander A
BONE MARROW TRANSPL. 2009.

Syngenic graft-versus-chronic-myeloid-leukemia-effect?
Ocheni S, Schafhausen P, Bacher U, Fehse B, Kröger N
CTT-Cell Ther Transpl. 2009;1(3):66-68.

Lentiviral gene ontology (LeGO) vectors equipped with novel drug-selectable fluorescent proteins: new building blocks for cell marking and multi-gene analysis.
Riecken K, Mock U, Petrowitz B, Bartsch U, Fehse B
GENE THER. 2009.

Diva-Fit: A step-by-step manual for generating high-resolution graphs and histogram overlays of flow cytometry data obtained with FACSDiva software
Riecken K, Fehse B
CTT-Cell Ther Transpl. 2009;1(4):1-4.

2008

CD4+CD25+FOXP3+ T regulatory cells reconstitute and accumulate in the bone marrow of patients with multiple myeloma following allogeneic stem cell transplantation.
Atanackovic D, Cao Y, Luetkens T, Panse J, Faltz C, Arfsten J, Bartels K, Wolschke C, Eiermann T, Zander A, Fehse B, Bokemeyer C, Kröger N
HAEMATOLOGICA. 2008;93(3):423-430.

Anti-thymocyte globulin overcomes the negative impact of HLA mismatching in transplantation from unrelated donors.
Ayuketang Ayuk F, Diyachenko G, Zabelina T, Panse J, Wolschke C, Eiermann T, Binder T, Fehse B, Erttmann R, Kabisch H, Bacher U, Kröger N, Zander A
EXP HEMATOL. 2008;36(8):1047-1054.

Complement-dependent and complement-independent cytotoxicity of polyclonal antithymocyte globulins in chronic lymphocytic leukemia.
Ayuketang Ayuk F, Atassi N, Schuch G, Mina S, Fang L, Bokemeyer C, Fehse B, Zander A, Kröger N
LEUKEMIA RES. 2008;32(8):1200-1206.

Comparison of two doses of antithymocyte globulin in patients undergoing matched unrelated donor allogeneic stem cell transplantation.
Ayuketang Ayuk F, Diyachenko G, Zabelina T, Wolschke C, Fehse B, Bacher U, Erttmann R, Kröger N, Zander A
BIOL BLOOD MARROW TR. 2008;14(8):913-919.

Minimal residual disease diagnostics in myeloid malignancies in the post transplant period.
Bacher U, Zander A, Haferlach T, Schnittger S, Fehse B, Kröger N
BONE MARROW TRANSPL. 2008;42(3):145-157.

Abnormal expression of only the CD34 part of a transgenic CD34/herpes simplex virus-thymidine kinase fusion protein is associated with ganciclovir resistance.
Bennour E, Ferrand C, Rémy-Martin J, Certoux J, Gorke S, Qasim W, Gaspar H, Baumert T, Duperrier A, Deschamps M, Fehse B, Tiberghien P, Robinet E
HUM GENE THER. 2008;19(7):699-709.

Insertional mutagenesis and clonal dominance: biological and statistical considerations.
Fehse B, Roeder I
GENE THER. 2008;15(2):143-153.

Clinical application of a retroviral gene transfer protocol based on centrifugation-mediated vector preloading.
Fehse B
HUM GENE THER. 2008;19(6):655-658.

Overexpression of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase inhibits GM-CSF-dependent colony formation of CD34+ hematopoietic progenitor cells.
Hoxha E, Fehse B, Ortmeyer G, Stocking C, Mayr G, Jücker M
LEUKEMIA LYMPHOMA. 2008;49(6):1206-1208.

Retroviral integration site analysis in hematopoietic stem cells.
Kustikova O, Baum C, Fehse B
Methods Mol Biol. 2008;430:255-267.

Transportation and cryopreservation may impair haematopoietic stem cell function and engraftment of allogeneic PBSCs, but not BM.
Lioznov M, Dellbrügger C, Sputtek A, Fehse B, Kröger N, Zander A
BONE MARROW TRANSPL. 2008;42(2):121-128.

Monitoring of minimal residual disease in multiple myeloma after allo-SCT: flow cytometry vs PCR-based techniques.
Lioznov M, Badbaran A, Fehse B, Bacher U, Zander A, Kröger N
BONE MARROW TRANSPL. 2008;41(10):913-916.

Resistance of mature T cells to oncogene transformation.
Newrzela S, Cornils K, Li Z, Baum C, Brugman M, Hartmann M, Meyer J, Hartmann S, Hansmann M, Fehse B, von Laer D
BLOOD. 2008;112(6):2278-2286.

Differences in proportion and dynamics of recipient hematopoiesis following hematopoietic cell transplantation in CML and IMF.
Siebolts U, Thiele J, Zander T, Ditschkowski M, Beelen D, Kröger N, Fehse B, Wickenhauser C
ONCOL REP. 2008;19(1):287-292.

A multicolor panel of novel lentiviral "gene ontology" (LeGO) vectors for functional gene analysis.
Weber K, Bartsch U, Stocking C, Fehse B
MOL THER. 2008;16(4):698-706.

2007

Monitoring of the JAK2-V617F mutation by highly sensitive quantitative real-time PCR after allogeneic stem cell transplantation in patients with myelofibrosis.
Kröger N, Badbaran A, Holler E, Hahn J, Kobbe G, Bornhäuser M, Reiter A, Zabelina T, Zander A, Fehse B
BLOOD. 2007;109(3):1316-1321.

Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways.
Kustikova O, Geiger H, Li Z, Brugman M, Chambers S, Shaw C, Pike-Overzet K, de Ridder D, Staal F, von Keudell G, Cornils K, Nattamai K, Modlich U, Wagemaker G, Goodell M, Fehse B, Baum C
BLOOD. 2007;109(5):1897-1907.

CD34 modulates the trafficking behavior of hematopoietic cells in vivo.
Lange C, Li Z, Fang L, Baum C, Fehse B
STEM CELLS DEV. 2007;16(2):297-304.

Insertional mutagenesis by replication-deficient retroviral vectors encoding the large T oncogene.
Li Z, Kustikova O, Kamino K, Neumann T, Rhein M, Grassman E, Fehse B, Baum C
ANN NY ACAD SCI. 2007;1106:95-113.

Gene transfer of SHIP-1 inhibits proliferation of juvenile myelomonocytic leukemia cells carrying KRAS2 or PTPN11 mutations.
Metzner A, Horstmann M, Fehse B, Ortmeyer G, Niemeyer C, Stocking C, Mayr G, Jücker M
GENE THER. 2007;14(8):699-703.

Remarkable leukemogenic potency and quality of a constitutively active neurotrophin receptor, deltaTrkA.
Meyer J, Rhein M, Schiedlmeier B, Kustikova O, Rudolph C, Kamino K, Neumann T, Yang M, Wahlers A, Fehse B, Reuther G, Schlegelberger B, Ganser A, Baum C, Li Z
LEUKEMIA. 2007;21(10):2171-2180.

2006

Mutagenesis and oncogenesis by chromosomal insertion of gene transfer vectors.
Baum C, Kustikova O, Modlich U, Li Z, Fehse B
HUM GENE THER. 2006;17(3):253-263.

Sensitive balance of suppressing and activating effects of mesenchymal stem cells on T-cell proliferation.
Fang L, Lange C, Engel M, Zander A, Fehse B
TRANSPLANTATION. 2006;82(10):1370-1373.

Retroviral vector insertions in T-lymphocytes used for suicide gene therapy occur in gene groups with specific molecular functions.
Giordano F, Fehse B, Hotz-Wagenblatt A, Jonnakuty S, Del Val C, Appelt J, Nagy K, Kuehlcke K, Naundorf S, Zander A, Zeller W, Ho A, Fruehauf S, Laufs S
BONE MARROW TRANSPL. 2006;38(3):229-235.

Kinetics of plasma-cell chimerism after allogeneic stem cell transplantation by highly sensitive real-time PCR based on sequence polymorphism and its value to quantify minimal residual disease in patients with multiple myeloma.
Kröger N, Zagrivnaja M, Schwartz S, Badbaran A, Zabelina T, Lioznov M, Ayuketang Ayuk F, Zander A, Fehse B
EXP HEMATOL. 2006;34(5):688-694.

CD34(+)-selected stem cell boost for delayed or insufficient engraftment after allogeneic stem cell transplantation.
Oyekunle A, Koehl U, Schieder H, Ayuketang Ayuk F, Renges H, Fehse N, Zabelina T, Fehse B, Klingebiel T, Sputtek A, Zander A, Kröger N
CYTOTHERAPY. 2006;8(4):375-380.

Allogeneic stem-cell transplantation in patients with refractory acute leukemia: a long-term follow-up.
Oyekunle A, Kröger N, Zabelina T, Ayuketang Ayuk F, Schieder H, Renges H, Fehse N, Waschke O, Fehse B, Kabisch H, Zander A
BONE MARROW TRANSPL. 2006;37(1):45-50.

2005

Analysis of progenitor cell mobilization and erythropoietin plasma levels in patients with acute myocardial infarction
Krause K, Fehse B, Jaquet K, Lange C, Kyriazis K, Boczor S, Zander A, Kuck K
EXP CLIN CARDIOL. 2005;10(2):104-7.

2004

Low-dose thalidomide and donor lymphocyte infusion as adoptive immunotherapy after allogeneic stem cell transplantation in patients with multiple myeloma.
Kröger N, Shimoni A, Zagrivnaja M, Ayuketang Ayuk F, Lioznov M, Schieder H, Renges H, Fehse B, Zabelina T, Nagler A, Zander A
BLOOD. 2004;104(10):3361-3363.

2003

Influence of anti-thymocyte globulin as part of the conditioning regimen on immune reconstitution following matched related bone marrow transplantation.
Fehse N, Fehse B, Kröger N, Zabelina T, Freiberger P, Krüger W, Kabisch H, Erttmann R, Zander A
J Hematother Stem Cell Res. 2003;12(2):237-242.

Hepatic lineages isolated from developing rat liver show different ways of maturation.
Fiegel H, Kluth J, Lioznov M, Holzhüter S, Fehse B, Zander A, Kluth D
BIOCHEM BIOPH RES CO. 2003;305(1):46-53.

Predictable and efficient retroviral gene transfer into murine bone marrow repopulating cells using a defined vector dose
Li Z, Schwieger M, Lange C, Kraunus J, Sun H, van den Akker E, Modlich U, Serinsöz E, Will E, von Laer D, Stocking C, Fehse B, Schiedlmeier B, Baum C
Experimental hematology. 2003;31(12):1206-14.

2002

Autologous stem cell transplantation followed by a dose-reduced allograft induces high complete remission rate in multiple myeloma.
Kröger N, Schwerdtfeger R, Kiehl M, Sayer H, Renges H, Zabelina T, Fehse B, Tögel F, Wittkowsky G, Kuse R, Zander A
BLOOD. 2002;100(3):755-760.

1999

Rapid and efficient cloning of proviral flanking fragments by kanamycin resistance gene complementation
Fehse B, Kühlcke K, Langer A, Ostertag W, Lother H
NUCLEIC ACIDS RES. 1999;27(2):706-7.

1998

Highly-efficient gene transfer with retroviral vectors into human T lymphocytes on fibronectin
Fehse B, Schade U, Li Z, Uhde A, Koch S, Goller B, Rüger R, Fehse N, Stockschläder M, Zander A
BRIT J HAEMATOL. 1998;102(2):566-74.

Dominant selection of hematopoietic progenitor cells with retroviral MDR1 co-expression vectors
Hildinger M, Fehse B, Hegewisch-Becker S, John J, Rafferty J, Ostertag W, Baum C
HUM GENE THER. 1998;9(1):33-42.

1995

Excision of specific DNA-sequences from integrated retroviral vectors via site-specific recombination
Bergemann J, Kühlcke K, Fehse B, Ratz I, Ostertag W, Lother H
NUCLEIC ACIDS RES. 1995;23(21):4451-6.

Letzte Aktualisierung aus dem FIS: 24.05.2017 - 00:25 Uhr