Björn Busse
Univ.-Prof. Dr. rer. medic.
Björn Busse
  • Wissenschaftler
  • Forschungsgruppenleiter


Lottestraße 55a, 22529 Hamburg, EG, Raumnummer 05
Deutsch (Muttersprache)




Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica
Chan W, Steiner M, Witkos T, Egerer J, Busse B, Mizumoto S, Pestka J, Zhang H, Hausser I, Khayal L, Ott C, Kolanczyk M, Willie B, Schinke T, Paganini C, Rossi A, Sugahara K, Amling M, Knaus P, Chan D, Lowe M, Mundlos S, Kornak U
PLOS GENET. 2018 [Epub ahead of print];14(3):e1007242.

Perturbed bone composition and integrity with disorganized osteoblast function in zinc receptor/Gpr39-deficient mice
Jovanovic M, Schmidt F, Guterman-Ram G, Khayyeri H, Hiram-Bab S, Orenbuch A, Katchkovsky S, Aflalo A, Isaksson H, Busse B, Jähn K, Levaot N
FASEB J. 2018.

Perturbed bone composition and integrity with disorganized osteoblast function in zinc receptor/Gpr39-deficient mice
Jovanovic M, Schmidt F, Guterman-Ram G, Khayyeri H, Hiram-Bab S, Orenbuch A, Katchkovsky S, Aflalo A, Isaksson H, Busse B, Jähn K, Levaot N
FASEB J. 2018 [Epub ahead of print];fj201700661RR.

Early bone tissue aging in human auditory ossicles is accompanied by excessive hypermineralization, osteocyte death and micropetrosis
Rolvien T, Schmidt F, Milovanovic P, Jähn K, Riedel C, Butscheidt S, Püschel K, Jeschke A, Amling M, Busse B
SCI REP-UK. 2018;8(1):1920.

Physiological and pathological osteocyte osteolysis
Tsourdi E, Jähn K, Rauner M, Busse B, Bonewald L
Journal of Musculoskeletal and Neuronal Interactions. 2018 [Epub ahead of print].


Calcium and vitamin-D deficiency marginally impairs fracture healing but aggravates posttraumatic bone loss in osteoporotic mice
Fischer V, Haffner-Luntzer M, Prystaz K, Scheidt A, Busse B, Schinke T, Amling M, Ignatius A
SCI REP-UK. 2017;7(1):Art. 7223.

Cobalt deposition in mineralized bone tissue after metal-on-metal hip resurfacing: Quantitative μ-X-ray-fluorescence analysis of implant material incorporation in periprosthetic tissue
Hahn M, Busse B, Procop M, Zustin J, Amling M, Katzer A
J BIOMED MATER RES B. 2017;105(7):1855-1862.

Association between regional heterogeneity in the mid-facial bone micro-architecture and increased fragility along Le Fort lines
Janovic A, Milovanovic P, Hahn M, Rakocevic Z, Amling M, Busse B, Dimitrijevic M, Djuric M
DENT TRAUMATOL. 2017;33(4):300-306.

Atypical fracture with long-term bisphosphonate therapy is associated with altered cortical composition and reduced fracture resistance
Lloyd A, Gludovatz B, Riedel C, Luengo E, Saiyed R, Marty E, Lorich D, Lane J, Ritchie R, Busse B, Donnelly E
P NATL ACAD SCI USA. 2017;114(33):8722-8727.

Region-dependent patterns of trabecular bone growth in the human proximal femur: A study of 3D bone microarchitecture from early postnatal to late childhood period
Milovanovic P, Djonic D, Hahn M, Amling M, Busse B, Djuric M
AM J PHYS ANTHROPOL . 2017;164(2):281-291.

The Formation of Calcified Nanospherites during Micropetrosis Represents a Unique Mineralization Mechanism in Aged Human Bone
Milovanovic P, Zimmermann E, vom Scheidt A, Hoffmann B, Sarau G, Yorgan T, Schweizer M, Amling M, Christiansen S, Busse B
SMALL. 2017;13(3):n/a-n/a.

The incorporation of fluoride and strontium in hydroxyapatite affects the composition, structure, and mechanical properties of human cortical bone
Riedel C, Zimmermann E, Zustin J, Niecke M, Amling M, Grynpas M, Busse B
J BIOMED MATER RES A. 2017;105(2):433-442.

ß-TCP bone substitutes in tibial plateau depression fractures
Rolvien T, Barvencik F, Klatte T, Busse B, Hahn M, Rueger J, Rupprecht M
KNEE. 2017;24(5):1138-1145.

Vertebral bone microarchitecture and osteocyte characteristics of three toothed whale species with varying diving behaviour
Rolvien T, Hahn M, Siebert U, Püschel K, Wilke H, Busse B, Amling M, Oheim R
SCI REP-UK. 2017;7(1):1604.

Vitamin D regulates osteocyte survival and perilacunar remodeling in human and murine bone
Rolvien T, Krause M, Jeschke A, Yorgan T, Püschel K, Schinke T, Busse B, Demay M, Amling M
BONE. 2017;103:78-87.

Assessment of collagen quality associated with non-enzymatic cross-links in human bone using Fourier-transform infrared imaging
Schmidt F, Zimmermann E, Campbell G, Sroga G, Püschel K, Amling M, Tang S, Vashishth D, Busse B
BONE. 2017;97:243-251.


Application of reference point indentation for micro-mechanical surface characterization of calcium silicate based dental materials
Antonijevic D, Milovanovic P, Riedel C, Hahn M, Amling M, Busse B, Djurić M

The assessment of adipocere to estimate the post-mortem interval - a skeleton from the tidelands
Jopp-van Well E, Augustin C, Busse B, Fuhrmann A, Hahn M, Tsokos M, Verhoff M, Schulz F
ANTHROPOL ANZ. 2016;73(3):235-247.

Zellulärer vs. azellulärer Knochen Eine Übersicht mit Hauptaugenmerk auf Echten Knochenfischen (Teleostei)
Rolvien T, Busse B
OSTEOLOGIE. 2016;25(2):77-82.

How the European eel (Anguilla anguilla) loses its skeletal framework across lifetime
Rolvien T, Nagel F, Milovanovic P, Wuertz S, Marshall R, Jeschke A, Schmidt F, Hahn M, Witten P, Amling M, Busse B
P ROY SOC B-BIOL SCI. 2016;283(1841):pii: 20161550.

Chronic skin inflammation leads to bone loss by IL-17-mediated inhibition of Wnt signaling in osteoblasts
Uluçkan Ö, Jimenez M, Karbach S, Jeschke A, Graña O, Keller J, Busse B, Croxford A, Finzel S, Koenders M, van den Berg W, Schinke T, Amling M, Waisman A, Schett G, Wagner E
SCI TRANSL MED. 2016;8(330):330ra37.

Eigenschaften des Osteozytennetzwerks in gesundem und erkranktem Knochen
Vom Scheidt A, Busse B
OSTEOLOGIE. 2016;25(2):69-76.

Osteoblast-specific Notch2 inactivation causes increased trabecular bone mass at specific sites of the appendicular skeleton
Yorgan T, Vollersen N, Riedel C, Jeschke A, Peters S, Busse B, Amling M, Schinke T
BONE. 2016;87:136-46.

Intrinsic mechanical behavior of femoral cortical bone in young, osteoporotic and bisphosphonate-treated individuals in low- and high energy fracture conditions
Zimmermann E, Schaible E, Gludovatz B, Schmidt F, Riedel C, Krause M, Vettorazzi E, Acevedo C, Hahn M, Püschel K, Tang S, Amling M, Ritchie R, Busse B
SCI REP-UK. 2016;6:21072.


Alendronate treatment alters bone tissues at multiple structural levels in healthy canine cortical bone
Acevedo C, Bale H, Gludovatz B, Wat A, Tang S, Wang M, Busse B, Zimmermann E, Schaible E, Allen M, Burr D, Ritchie R
BONE. 2015;81:352-363.

Addition of a Fluoride-containing Radiopacifier Improves Micromechanical and Biological Characteristics of Modified Calcium Silicate Cements
Antonijevic D, Jeschke A, Colovic B, Milovanovic P, Jevremovic D, Kisic D, Scheidt A, Hahn M, Amling M, Jokanovic V, Busse B, Djuric M
J ENDOD. 2015;41(12):2050-2057.

Microstructure and wettability of root canal dentine and root canal filling materials after different chemical irrigation
Antonijevic D, Milovanovic P, Brajkovic D, Ilic D, Hahn M, Amling M, Rakocevic Z, Djuric M, Busse B
APPL SURF SCI. 2015;355:369-378.

Bone microarchitecture at muscle attachment sites: The relationship between macroscopic scores of entheses and their cortical and trabecular microstructural design
Djukic K, Milovanovic P, Hahn M, Busse B, Amling M, Djuric M
AM J PHYS ANTHROPOL . 2015;157(1):81-93.

Impaired bone remodeling and its correction by combination therapy in a mouse model of mucopolysaccharidosis-I
Kühn S, Koehne T, Cornils K, Markmann S, Riedel C, Pestka J, Schweizer M, Baldauf C, Yorgan T, Krause M, Keller J, Neven M, Breyer S, Stücker R, Muschol N, Busse B, Braulke T, Fehse B, Amling M, Schinke T
HUM MOL GENET. 2015;24(24):7075-7086.

Age- and Sex-Specific Bone Structure Patterns Portend Bone Fragility in Radii and Tibiae in Relation to Osteodensitometry: A High-Resolution Peripheral Quantitative Computed Tomography Study in 385 Individuals
Milovanovic P, Adamu U, Simon M, Rolvien T, Djuric M, Amling M, Busse B
J GERONTOL A BIOL SCI MED SCI. 2015;70(10):1269-75.

Multi-level characterization of human femoral cortices and their underlying osteocyte network reveal trends in quality of young, aged, osteoporotic and antiresorptive-treated bone
Milovanovic P, Zimmermann E, Riedel C, Scheidt A, Herzog L, Krause M, Djonic D, Djuric M, Püschel K, Amling M, Ritchie R, Busse B
BIOMATERIALS. 2015;45:46-55.

The fracture mechanics of human bone: influence of disease and treatment
Zimmermann E, Busse B, Ritchie R
Bonekey Rep. 2015;4:743.

Modifications to nano- and microstructural quality and the effects on mechanical integrity in Paget's disease of bone
Zimmermann E, Köhne T, Bale H, Panganiban B, Gludovatz B, Zustin J, Hahn M, Amling M, Ritchie R, Busse B
J BONE MINER RES. 2015;30(2):264-73.


Altered lacunar and vascular porosity in osteogenesis imperfecta mouse bone as revealed by synchrotron tomography contributes to bone fragility
Carriero A, Doube M, Vogt M, Busse B, Zustin J, Levchuk A, Schneider P, Müller R, Shefelbine S
BONE. 2014;61:116-24.

How tough is brittle bone? Investigating osteogenesis imperfecta in mouse bone
Carriero A, Zimmermann E, Paluszny A, Tang S, Bale H, Busse B, Alliston T, Kazakia G, Ritchie R, Shefelbine S
J BONE MINER RES. 2014;29(6):1392-1401.

Microstructural properties of the mid-facial bones in relation to the distribution of occlusal loading
Janovic A, Milovanovic P, Saveljic I, Nikolic D, Hahn M, Rakocevic Z, Filipovic N, Amling M, Busse B, Djuric M
BONE. 2014;68:108-14.

Bisphosphonate-osteoclasts: changes in osteoclast morphology and function induced by antiresorptive nitrogen-containing bisphosphonate treatment in osteoporosis patients
Jobke B, Milovanovic P, Amling M, Busse B
BONE. 2014;59:37-43.

Trends in trabecular architecture and bone mineral density distribution in 152 individuals aged 30-90 years
Koehne T, Vettorazzi E, Küsters N, Lüneburg R, Kahl-Nieke B, Püschel K, Amling M, Busse B
BONE. 2014.

Effects of long-term alendronate treatment on bone mineralisation, resorption parameters and biomechanics of single human vertebral trabeculae
Krause M, Soltau M, Zimmermann E, Hahn M, Kornet J, Hapfelmeier A, Breer S, Morlock M, Wulff B, Püschel K, Glueer C, Amling M, Busse B
EUR CELLS MATER. 2014;28:152-165.

Nano-structural, compositional and micro-architectural signs of cortical bone fragility at the superolateral femoral neck in elderly hip fracture patients vs. healthy aged controls
Milovanovic P, Rakocevic Z, Djonic D, Zivkovic V, Hahn M, Nikolic S, Amling M, Busse B, Djuric M
EXP GERONTOL. 2014;55:19-28.

High fluoride and low calcium levels in drinking water is associated with low bone mass, reduced bone quality and fragility fractures in sheep
Simon M, Beil F, Ruther W, Busse B, Koehne T, Steiner M, Pogoda P, Ignatius A, Amling M, Oheim R
OSTEOPOROSIS INT. 2014;25(7):1891-1903.

Fracture resistance of human cortical bone across multiple length-scales at physiological strain rates
Zimmermann E, Gludovatz B, Schaible E, Busse B, Ritchie R
BIOMATERIALS. 2014;35(21):5472-5481.


Micro-morphological properties of osteons reveal changes in cortical bone stability during aging, osteoporosis, and bisphosphonate treatment in women
Bernhard A, Milovanovic P, Zimmermann E, Hahn M, Djonic D, Krause M, Breer S, Püschel K, Djuric M, Amling M, Busse B
OSTEOPOROSIS INT. 2013;24(10):2671-80.

Vitamin D deficiency induces early signs of aging in human bone, increasing the risk of fracture
Busse B, Bale H, Zimmermann E, Panganiban B, Barth H, Carriero A, Vettorazzi E, Zustin J, Hahn M, Ager J, Püschel K, Amling M, Ritchie R
SCI TRANSL MED. 2013;5(193):193ra88.

Osteocytic canalicular Networks: morphological implications for altered mechanosensitivity
Milovanovic P, Zimmermann E, Hahn M, Djonic D, Püschel K, Djuric M, Amling M, Busse B
ACS NANO. 2013;7(9):7542-51.

Impaired bone mineralization accompanied by low vitamin D and secondary hyperparathyroidism in patients with femoral neck fracture.
Seitz S, Koehne T, Ries C, Novo De Oliveira A, Barvencik F, Busse B, zu Eulenburg C, Schinke T, Püschel K, Rueger J, Amling M, Pogoda P
OSTEOPOROSIS INT. 2013;24(2):641-649.

Scaling of Haversian canal surface area to secondary osteon bone volume in ribs and limb bones
Skedros J, Knight A, Clark G, Crowder C, Dominguez V, Qiu S, Mulhern D, Donahue S, Busse B, Hulsey B, Zedda M, Sorenson S
AM J PHYS ANTHROPOL . 2013;151(2):230-44.


Analysis of retrieved hip resurfacing arthroplasties reveals the interrelationship between interface hyperosteoidosis and demineralization of viable bone trabeculae.
Breer S, Krause M, Busse B, Hahn M, Rüther W, Morlock M, Amling M, Zustin J
J ORTHOP RES. 2012;30(7):1155-1161.

Divergent resorbability and effects on osteoclast formation of commonly used bone substitutes in a human in vitro-assay.
Keller J, Brink S, Busse B, Schilling A, Schinke T, Amling M, Lange T
PLOS ONE. 2012;7(10):46757.

Changes to the cell, tissue and architecture levels in cranial suture synostosis reveal a problem of timing in bone development.
Regelsberger J, Milovanovic P, Schmidt T, Hahn M, Zimmermann E, Tsokos M, Zustin J, Ritchie R, Amling M, Busse B
EUR CELLS MATER. 2012;24:441-458.

Accelerated growth plate mineralization and foreshortened proximal limb bones in fetuin-A knockout mice
Seto J, Busse B, Gupta H, Schäfer C, Krauss S, Dunlop J, Masic A, Kerschnitzki M, Zaslansky P, Boesecke P, Catalá-Lehnen P, Schinke T, Fratzl P, Jahnen-Dechent W
PLOS ONE. 2012;7(10):e47338.


Skeletal mineralization defects in adult hypophosphatasia-a clinical and histological analysis.
Barvencik F, Beil F, Gebauer M, Busse B, Köhne T, Seitz S, Zustin J, Pogoda P, Schinke T, Amling M
OSTEOPOROSIS INT. 2011;22(10):2667-2675.

Trabecular reorganization in consecutive iliac crest biopsies when switching from bisphosphonate to strontium ranelate treatment.
Jobke B, Burghardt A, Muche B, Hahn M, Semler J, Amling M, Majumdar S, Busse B
PLOS ONE. 2011;6(8):23638.

Age-related changes in the plasticity and toughness of human cortical bone at multiple length scales
Zimmermann E, Schaible E, Bale H, Barth H, Tang S, Reichert P, Busse B, Alliston T, Ager J, Ritchie R
P NATL ACAD SCI USA. 2011;108(35):14416-21.


Decrease in the osteocyte lacunar density accompanied by hypermineralized lacunar occlusion reveals failure and delay of remodeling in aged human bone.
Busse B, Djonic D, Milovanovic P, Hahn M, Püschel K, Ritchie R, Djuric M, Amling M
AGING CELL. 2010;9(6):1065-1075.

Reorganization of the femoral cortex due to age-, sex-, and endoprosthetic-related effects emphasized by osteonal dimensions and remodeling.
Busse B, Hahn M, Schinke T, Püschel K, Duda G, Amling M
J BIOMED MATER RES A. 2010;92(4):1440-1451.

Synchrotron-microcomputed tomography studies of normal and pathological cranial sutures: further insight.
Regelsberger J, Schmidt T, Busse B, Herzen J, Tsokos M, Amling M, Beckmann F
J NEUROSURG-PEDIATR. 2010;5(3):238-242.

Negative regulation of bone formation by the transmembrane Wnt antagonist Kremen-2.
Schulze J, Seitz S, Saito H, Schneebauer M, Marshall R, Baranowsky A, Busse B, Schilling A, Friedrich F, Albers J, Spiro A, Zustin J, Streichert T, Ellwanger K, Niehrs C, Amling M, Baron R, Schinke T
PLOS ONE. 2010;5(4):10309.

High bone turnover and accumulation of osteoid in patients with neurofibromatosis 1.
Seitz S, Schnabel C, Busse B, Schmidt H, Beil F, Friedrich R, Schinke T, Mautner V, Amling M
OSTEOPOROSIS INT. 2010;21(1):119-127.


Increased calcium content and inhomogeneity of mineralization render bone toughness in osteoporosis: mineralization, morphology and biomechanics of human single trabeculae.
Busse B, Hahn M, Soltau M, Zustin J, Püschel K, Duda G, Amling M
BONE. 2009;45(6):1034-1043.


Allocation of nonbirefringent wear debris: darkfield illumination associated with PIXE microanalysis reveals cobalt deposition in mineralized bone matrix adjacent to CoCr implants.
Busse B, Hahn M, Niecke M, Jobke B, Püschel K, Delling G, Katzer A
J BIOMED MATER RES A. 2008;87(2):536-545.


Polyethylen-Abrieb: Ursache oder Folge einer Endoprothesenlockerung? Untersuchungen an festen und gelockerten Hüftendoprothesen
Busse B, Niecke M, Püschel K, Delling G, Katzer A, Hahn M
Z ORTHOP UNFALLCHIR. 2007;145(4):452-60.

[Polyethylene abrasion: cause or consequence of an endoprosthesis loosening? Investigations of firm and loosened hip implants]
Busse B, Niecke M, Püschel K, Delling G, Katzer A, Hahn M
Z ORTHOP UNFALLCHIR. 2007;145(4):452-460.


[Fluorosis--a forgotten entity. Case report of a woman with coxarthrosis and newly diagnosed fluorosis].
Busse B, Jobke B, Werner M, Fuerst M, Rüther W, Delling G
PATHOLOGE. 2006;27(1):73-79.

Fluoridosteopathie--eine vergessene Entität. Gleichzeitiges Auftreten von Coxarthrose und bis dahin unbekannter Fluoridosteopathie bei einer 73-jährigen Patientin
Busse B, Jobke B, Werner M, Fürst M, Ruther W, Delling G
PATHOLOGE. 2006;27(1):73-9.

Letzte Aktualisierung aus dem FIS: 23.04.2018 - 00:04 Uhr