Malte Mohme
Priv.-Doz. Dr. med.
Malte Mohme
FEBNS
  • Oberarzt
  • Arbeitsgruppenleiter
  • Facharzt für Neurochirurgie
  • Prüfarzt (Arzneimittelgesetz)
  • Zertifikat „Spezielle Neurochirurgische Onkologie“ (NCA)
  • AG Leiter "CNS Tumor-Immunology"
Arbeitsbereich

Kontakt

Standort

Hauptgebäude O10 , 2. Etage
Sprachen
Deutsch (Muttersprache)
Englisch

Fachgebiete

Tätigkeitsschwerpunkte

Auszeichnungen

Mitgliedschaften

Publikationen

2024

Unveiling breast cancer metastasis through an advanced X-ray imaging approach
Conceição A, Müller V, Burandt E, Mohme M, Nielsen L, Liebi M, Haas S
SCI REP-UK. 2024;14(1):1448.

Unclassifiable CNS tumors in DNA methylation-based classification: clinical challenges and prognostic impact
Drexler R, Brembach F, Sauvigny J, Ricklefs F, Eckhardt A, Bode H, Gempt J, Lamszus K, Westphal M, Schüller U, Mohme M
ACTA NEUROPATHOL COM. 2024;12(1):9.

Temporal change of DNA methylation subclasses between matched newly diagnosed and recurrent glioblastoma
Drexler R, Khatri R, Schüller U, Eckhardt A, Ryba A, Sauvigny T, Dührsen L, Mohme M, Ricklefs T, Bode H, Hausmann F, Huber T, Bonn S, Voß H, Neumann J, Silverbush D, Hovestadt V, Suvà M, Lamszus K, Gempt J, Westphal M, Heiland D, Hänzelmann S, Ricklefs F
ACTA NEUROPATHOL. 2024;147(1):21.

SARS-CoV-2-associated T-cell infiltration in the central nervous system
Mohme M, Schultheiß C, Piffko A, Fitzek A, Paschold L, Thiele B, Püschel K, Glatzel M, Westphal M, Lamszus K, Matschke J, Binder M
CLIN TRANSL IMMUNOL. 2024;13(2):e1487.

Circulating Tumor Cells and Thromboembolic Events in Patients with Glioblastoma
Rolling C, Mohme M, Bokemeyer C, Westphal M, Riethdorf S, Lamszus K, Pantel K, Klingler F, Langer F
HAMOSTASEOLOGIE. 2024 [Epub ahead of print].

Insights from a Multicenter Study on Adult H3 K27M-Mutated Glioma: Surgical Resection's Limited Influence on Overall Survival, ATRX as Molecular Prognosticator
Ryba A, Özdemir Z, Nissimov N, Hönikl L, Neidert N, Jakobs M, Kalasauskas D, Krigers A, Thomé C, Freyschlag C, Ringel F, Unterberg A, Dao Trong P, Beck J, Heiland D, Meyer B, Vajkoczy P, Onken J, Stummer W, Suero Molina E, Gempt J, Westphal M, Schüller U, Mohme M
NEURO-ONCOLOGY. 2024 [Epub ahead of print].

2023

Epigenetic neural glioblastoma enhances synaptic integration and predicts therapeutic vulnerability
Drexler R, Khatri R, Sauvigny T, Mohme M, Maire C, Ryba A, Zghaibeh Y, Dührsen L, Salviano-Silva A, Lamszus K, Westphal M, Gempt J, Wefers A, Neumann J, Bode H, Hausmann F, Huber T, Bonn S, Jütten K, Delev D, Weber K, Harter P, Onken J, Vajkoczy P, Capper D, Wiestler B, Weller M, Snijder B, Buck A, Weiss T, Keough M, Ni L, Monje M, Silverbush D, Hovestadt V, Suvà M, Krishna S, Hervey-Jumper S, Schüller U, Heiland D, Hänzelmann S, Ricklefs F
bioRxiv. 2023.

Rhizochalinin Exhibits Anticancer Activity and Synergizes with EGFR Inhibitors in Glioblastoma In Vitro Models
Dyshlovoy S, Hauschild J, Venz S, Krisp C, Kolbe K, Zapf S, Heinemann S, Fita K, Shubina L, Makarieva T, Guzii A, Rohlfing T, Kaune M, Busenbender T, Mair T, Moritz M, Poverennaya E, Schlüter H, Serdyuk V, Stonik V, Dierlamm J, Bokemeyer C, Mohme M, Westphal M, Lamszus K, von Amsberg G, Maire C
MOL PHARMACEUT. 2023;20(10):4994-5005.

A framework for standardised tissue sampling and processing during resection of diffuse intracranial glioma: joint recommendations from four RANO groups
Karschnia P, Smits M, Reifenberger G, Le Rhun E, Ellingson B, Galldiks N, Kim M, Huse J, Schnell O, Harter P, Mohme M, von Baumgarten L, Albert N, Huang R, Mehta M, van den Bent M, Weller M, Vogelbaum M, Chang S, Berger M, Tonn J
LANCET ONCOL. 2023;24(11):e438-e450.

Chimeric Antigen Receptor T Cells in Glioblastoma-Current Concepts and Promising Future
Kringel R, Lamszus K, Mohme M
CELLS-BASEL. 2023;12(13):1770.

Microbial peptides activate tumour-infiltrating lymphocytes in glioblastoma
Naghavian R, Faigle W, Oldrati P, Wang J, Toussaint N, Qiu Y, Medici G, Wacker M, Freudenmann L, Bonté P, Weller M, Regli L, Amigorena S, Rammensee H, Walz J, Brugger S, Mohme M, Zhao Y, Sospedra M, Neidert M, Martin R
NATURE. 2023;617(7962):807-817.

A 64-year progression of an intradiploic epidermoid of the frontal skull: illustrative case
Ott S, Lübke A, Mohme M, Westphal M
Journal of neurosurgery. Case lessons. 2023;6(25):.

Cavernous Malformations and Hemangioblastomas of the Spinal Cord Show Distinct Differences in Clinical Course - A Retrospective Single-Center Analysis of 112 Patients
Pantel T, Mende K, Mohme T, Mohme M, Viezens L, Matschke J, Westphal M, Eicker S
GLOB SPINE J. 2023 [Epub ahead of print];21925682231214363.

Corticosteroid-Dependent Leukocytosis Masks the Predictive Potential of White Blood Cells for Delayed Cerebral Ischemia and Ventriculoperitoneal Shunt Dependency in Aneurysmatic Subarachnoid Hemorrhage
Piffko A, Ricklefs F, Schweingruber N, Sauvigny T, Mader M, Mohme M, Dührsen L, Westphal M, Regelsberger J, Schmidt N, Czorlich P
J CLIN MED. 2023;12(3):.

Polio Virotherapy Targets the Malignant Glioma Myeloid Infiltrate with Diffuse Microglia Activation Engulfing the CNS
Yang Y, Brown M, Zhang G, Stevenson K, Mohme M, Kornahrens R, Bigner D, Ashley D, López G, Gromeier M
NEURO-ONCOLOGY. 2023;25(9):1631-1643.

2022

Operative Therapie spinaler Metastasen
Eicker S, Mohme M
ONKOLOGE. 2022;28:371–380.

17th German Spine Congress, Annual Meeting of the German Spine Society: Influence of psychological stress on outpatient treatment of patients with spinal disorders
Mohme M, Mende K, Mohme T, Stangenberg M, Pantel T, Heuer A, Fritsch G, Viezens L, Dreimann M, Eicker S
EUR SPINE J. 2022;31(11):3177-3177.

Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism
Monteiro C, Miarka L, Perea-García M, Priego N, García-Gómez P, Álvaro-Espinosa L, de Pablos-Aragoneses A, Yebra N, Retana D, Baena P, Fustero-Torre C, Graña-Castro O, Troulé K, Caleiras E, Tezanos P, Muela P, Cintado E, Trejo J, Sepúlveda J, González-León P, Jiménez-Roldán L, Moreno L, Esteban O, Pérez-Núñez Á, Hernández-Lain A, Mazarico Gallego J, Ferrer I, Suárez R, Garrido-Martín E, Paz-Ares L, Dalmasso C, Cohen-Jonathan Moyal E, Siegfried A, Hegarty A, Keelan S, Varešlija D, Young L, Mohme M, Goy Y, Wikman H, Fernández-Alén J, Blasco G, Alcázar L, Cabañuz C, Grivennikov S, Ianus A, Shemesh N, Faria C, Lee R, Lorigan P, Le Rhun E, Weller M, Soffietti R, Bertero L, Ricardi U, Bosch-Barrera J, Sais E, Teixidor E, Hernández-Martínez A, Calvo A, Aristu J, Martin S, Gonzalez A, Adler O, Erez N, Valiente M
NAT MED. 2022;28(4):752-765.

Clinical determinants impacting overall survival of patients with operable brain metastases from non-small cell lung cancer
Piffko A, Asey B, Dührsen L, Ristow I, Salamon J, Wikman H, Maire C, Lamszus K, Westphal M, Sauvigny T, Mohme M
FRONT ONCOL. 2022;12:.

Genetic and epigenetic profiling identifies two distinct classes of spinal meningiomas
Ricklefs F, Fita K, Mohme M, Mawrin C, Rahmanzade R, Sahm F, Dührsen L, Göbel C, Lamszus K, Westphal M, Schüller U, Eicker S
ACTA NEUROPATHOL. 2022;144(5):1057-1059.

Circulating tumor cells and extracellular vesicles as liquid biopsy markers in neuro-oncology: prospects and limitations
Westphal M, Pantel K, Ricklefs F, Maire C, Riethdorf S, Mohme M, Wikman H, Lamszus K
NEURO-ONCOL ADV. 2022;4(Suppl 2):ii45-ii52.

2021

Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling
Brown M, Mosaheb M, Mohme M, McKay Z, Holl E, Kastan J, Yang Y, Beasley G, Hwang E, Ashley D, Bigner D, Nair S, Gromeier M
NAT COMMUN. 2021;12(1):1858.

Carbon fiber-reinforced PEEK versus titanium implants - an in vitro comparison of susceptibility artifacts in CT and MR imaging
Krätzig T, Mende K, Mohme M, Kniep H, Dreimann M, Stangenberg M, Westphal M, Gauer T, Eicker S
NEUROSURG REV. 2021;44(4):2163-2170.

Bacterial adhesion characteristics on implant materials for intervertebral cages: titanium or PEEK for spinal infections?
Krätzig T, Mende K, Mohme M, von Kroge S, Stangenberg M, Dreimann M, Westphal M, Weisselberg S, Eicker S
EUR SPINE J. 2021;30(6):1774-1782.

CD74 and CD44 Expression on CTCs in Cancer Patients with Brain Metastasis
Loreth D, Schuette M, Zinke J, Mohme M, Piffko A, Schneegans S, Stadler J, Janning M, Loges S, Joosse S, Lamszus K, Westphal M, Müller V, Glatzel M, Matschke J, Gebhardt C, Schneider S, Belczacka I, Volkmer B, Greinert R, Yaspo M, Harter P, Pantel K, Wikman H
INT J MOL SCI. 2021;22(13):.

Intrathecal and systemic alterations of L-arginine metabolism in patients after intracerebral hemorrhage
Mader M, Böger R, Appel D, Schwedhelm E, Haddad M, Mohme M, Lamszus K, Westphal M, Czorlich P, Hannemann J
J CEREBR BLOOD F MET. 2021;41(8):1964-1977.

P02.01 A strategy to personalize the use of radiation in patients with brain metastasis based on S100A9-mediated resistance
Miarka L, Monteiro C, Dalmasso C, Yebra N, Fustero-Torre C, Hegarty A, Keelan S, Goy Y, Mohme M, Caleiras E, Vareslija D, Young L, Soffietti R, Fernández-Alén J, Blasco G, Alcázar L, Sepúlveda J, Pérez A, Lain A, Siegfried A, Wikman H, Cohen-Jonathan Moyal E, Valiente M
NEURO-ONCOLOGY. 2021;23(Supplement_2):ii17-ii17.

Intraoperative blood loss in oncological spine surgery
Mohme M, Mende K, Pantel T, Viezens L, Westphal M, Eicker S, Dreimann M, Krätzig T, Stangenberg M
NEUROSURG FOCUS. 2021;50(5):E14.

DIMEimmune: Robust estimation of infiltrating lymphocytes in CNS tumors from DNA methylation profiles
Safaei S, Mohme M, Niesen J, Schüller U, Bockmayr M
ONCOIMMUNOLOGY. 2021;10(1):.

Landscape of T-cell repertoires with public COVID-19-associated T-cell receptors in pre-pandemic risk cohorts
Simnica D, Schultheiß C, Mohme M, Paschold L, Willscher E, Fitzek A, Püschel K, Matschke J, Ciesek S, Sedding D, Zhao Y, Gagliani N, Maringer Y, Walz J, Heide J, Schulze-Zur-Wiesch J, Binder M
CLIN TRANSL IMMUNOL. 2021;10(9):e1340.

Influence of microbiological diagnosis on the clinical course of spondylodiscitis
Stangenberg M, Mende K, Mohme M, Krätzig T, Viezens L, Both A, Rohde H, Dreimann M
INFECTION. 2021;49(5):1017-1027.

Posterior vertebral column resection as a safe procedure leading to solid bone fusion in metastatic epidural spinal cord compression
Viezens L, Dreimann M, Eicker S, Heuer A, Koepke L, Mohme M, Krätzig T, Stangenberg M
NEUROSURG FOCUS. 2021;50(5):E8.

16th German Spine Congress Annual Meeting of the German Spine Society 9th to 11th December 2021 Muenster, Germany: Posterior vertebral column resection (pVCR) leads to clinically good results and a reliable osseous fusion in cases of epidural tumor growth with concomitant instability
Viezens L, Dreimann M, Eicker S, Heuer A, Köpke L, Mohme M, Mohme T, Stangenberg M
EUR SPINE J. 2021;30(11):3333-3333.

2020

Discovery of Targetable Genetic Alterations in NSCLC Patients with Different Metastatic Patterns Using a MassARRAY-Based Circulating Tumor DNA Assay
Belloum Y, Janning M, Mohme M, Simon R, Kropidlowski J, Sartori A, Irwin D, Westphal M, Lamszus K, Loges S, Riethdorf S, Pantel K, Wikman H
CELLS-BASEL. 2020;9(11):.

Glioma escape signature and clonal development under immune pressure
Maire C, Mohme M, Bockmayr M, Fita K, Riecken K, Börnigen D, Alawi M, Failla A, Kolbe K, Zapf S, Holz M, Neumann K, Dührsen L, Lange T, Fehse B, Westphal M, Lamszus K
J CLIN INVEST. 2020;130(10):5257-5271.

Local intracerebral immunomodulation using interleukin-expressing mesenchymal stem cells in glioblastoma
Mohme M, Maire C, Geumann U, Schliffke S, Dührsen L, Fita K, Akyüz N, Binder M, Westphal M, Guenther C, Lamszus K, Hermann F, Schmidt N
CLIN CANCER RES. 2020;26(11):2626-2639.

Molecular profiling of an osseous metastasis in glioblastoma during checkpoint inhibition: potential mechanisms of immune escape
Mohme M, Maire C, Schliffke S, Joosse S, Alawi M, Matschke J, Schüller U, Dierlamm J, Martens T, Pantel K, Riethdorf S, Lamszus K, Westphal M
ACTA NEUROPATHOL COM. 2020;8(1):.

Tumor-Specific T Cell Activation in Malignant Brain Tumors
Mohme M, Neidert M
FRONT IMMUNOL. 2020;11:205.

Next-Generation Sequencing of T and B Cell Receptor Repertoires from COVID-19 Patients Showed Signatures Associated with Severity of Disease
Schultheiß C, Paschold L, Simnica D, Mohme M, Willscher E, von Wenserski L, Scholz R, Wieters I, Dahlke C, Tolosa E, Sedding D, Ciesek S, Addo M, Binder M
IMMUNITY. 2020;53(2):442-455.e4.

Impact of the localization on disease course and clinical management in spondylodiscitis
Stangenberg M, Mohme M, Mende K, Thiesen D, Krätzig T, Schoof B, Eicker S, Dreimann M
INT J INFECT DIS. 2020;99:122-130.

2019

Immunologic Profiling of Mutational and Transcriptional Subgroups in Pediatric and Adult High-Grade Gliomas
Bockmayr M, Klauschen F, Maire C, Rutkowski S, Westphal M, Lamszus K, Schüller U, Mohme M
CANCER IMMUNOL RES. 2019;7(9):1401-1411.

Immune Characterization in Aneurysmal Subarachnoid Hemorrhage Reveals Distinct Monocytic Activation and Chemokine Patterns
Mohme M, Sauvigny T, Mader M, Schweingruber N, Maire C, Rünger A, Ricklefs F, Regelsberger J, Schmidt N, Westphal M, Lamszus K, Tolosa E, Czorlich P
TRANSL STROKE RES. 2019.

Clonality of circulating tumor cells in breast cancer brain metastasis patients
Riebensahm C, Joosse S, Mohme M, Hanssen A, Matschke J, Goy Y, Witzel I, Lamszus K, Kropidlowski J, Petersen C, Kolb-Kokocinski A, Sauer S, Borgmann K, Glatzel M, Müller V, Westphal M, Riethdorf S, Pantel K, Wikman H
BREAST CANCER RES. 2019;21(1):101.

Rate and risk factors for a hyperactivity delirium in patients with aneurysmal subarachnoid haemorrhage
Sauvigny T, Mohme M, Grensemann J, Dührsen L, Regelsberger J, Kluge S, Schmidt N, Westphal M, Czorlich P
NEUROSURG REV. 2019;42(2):481-488.

EGFR and HER3 expression in circulating tumor cells and tumor tissue from non-small cell lung cancer patients
Scharpenseel H, Hanssen A, Loges S, Mohme M, Bernreuther C, Peine S, Lamszus K, Goy Y, Petersen C, Westphal M, Glatzel M, Riethdorf S, Pantel K, Wikman H
SCI REP-UK. 2019;9(1):7406.

T cell receptor next-generation sequencing reveals cancer-associated repertoire metrics and reconstitution after chemotherapy in patients with hematological and solid tumors
Simnica D, Akyüz N, Schliffke S, Mohme M, V Wenserski L, Mährle T, Fanchi L, Lamszus K, Binder M
ONCOIMMUNOLOGY. 2019;8(11):e1644110.

2018

Subgroup-specific immune and stromal microenvironment in medulloblastoma
Bockmayr M, Mohme M, Klauschen F, Winkler B, Budczies J, Rutkowski S, Schüller U
ONCOIMMUNOLOGY. 2018;7(9):e1462430.

Frequency of Circulating Tumor Cells (CTC) in Patients with Brain Metastases: Implications as a Risk Assessment Marker in Oligo-Metastatic Disease
Hanssen A, Riebensahm C, Mohme M, Joosse S, Velthaus J, Berger L, Bernreuther C, Glatzel M, Loges S, Lamszus K, Westphal M, Riethdorf S, Pantel K, Wikman H
CANCERS. 2018;10(12):E527.

Tectal gliomas: Assessment of malignant progression, clinical management, and quality of life in a supposedly benign neoplasm
Mohme M, Fritzsche F, Mende K, Matschke J, Löbel U, Kammler G, Westphal M, Emami P, Martens T
NEUROSURG FOCUS. 2018;44(6):E15.

Immunophenotyping of Newly Diagnosed and Recurrent Glioblastoma Defines Distinct Immune Exhaustion Profiles in Peripheral and Tumor-infiltrating Lymphocytes
Mohme M, Schliffke S, Maire C, Rünger A, Glau L, Mende K, Matschke J, Gehbauer C, Akyüz N, Zapf S, Holz M, Schaper M, Martens T, Schmidt N, Peine S, Westphal M, Binder M, Tolosa E, Lamszus K
CLIN CANCER RES. 2018;24(17):4187-4200.

Inverse Perfusion Requirements of Supra- and Infratentorial Brain Metastases Formation
Schneider T, Kemmling A, Schroeder J, Pantel K, Glatzel M, Schoen G, Mohme M, Fiehler J, Gellißen S
FRONT NEUROL. 2018;9:391.

2017

Impact of the surgical strategy on the incidence of C5 nerve root palsy in decompressive cervical surgery
Krätzig T, Mohme M, Mende K, Eicker S, Floeth F
PLOS ONE. 2017;12(11):e0188338.

Keyhole approaches to intradural pathologies
Mende K, Krätzig T, Mohme M, Westphal M, Eicker S
NEUROSURG FOCUS. 2017;43(2):E5.

Optical Barcoding for Single-Clone Tracking to Study Tumor Heterogeneity
Mohme M, Maire C, Riecken K, Zapf S, Aranyossy T, Westphal M, Lamszus K, Fehse B
MOL THER. 2017;25(3):621-633.

Impact of spinal cord compression from intradural and epidural spinal tumors on perioperative symptoms-implications for surgical decision making
Mohme M, Mende C, Krätzig T, Plätke R, Beseoglu K, Hagedorn J, Steiger H, Floeth F, Eicker S
NEUROSURG REV. 2017;40(3):377-387.

Circulating Tumour Cell Release after Cement Augmentation of Vertebral Metastases
Mohme M, Riethdorf S, Dreimann M, Werner S, Maire C, Joosse S, Bludau F, Mueller V, Neves R, Stoecklein N, Lamszus K, Westphal M, Pantel K, Wikman H, Eicker S
SCI REP-UK. 2017;7(1):7196.

Circulating and disseminated tumour cells - mechanisms of immune surveillance and escape
Mohme M, Riethdorf S, Pantel K
NAT REV CLIN ONCOL. 2017;14(3):155-167.

Irreversible Total Loss of Brain Function and Organ Donation in Patients with Aneurysmal Subarachnoid Hemorrhage
Mohme M, Sauvigny T, Grensemann J, Söffker G, Kluge S, Westphal M, Czorlich P
WORLD NEUROSURG. 2017;105:492-497.

Edema is not a reliable diagnostic sign to exclude small brain metastases
Schneider T, Kuhne J, Bittrich P, Schroeder J, Magnus T, Mohme M, Grosser M, Schoen G, Fiehler J, Siemonsen S
PLOS ONE. 2017;12(5):e0177217.

Cervical vertebroplasty for osteolytic metastases as a minimally invasive therapeutic option in oncological surgery: outcome in 14 cases
Stangenberg M, Viezens L, Eicker S, Mohme M, Mende K, Dreimann M
NEUROSURG FOCUS. 2017;43(2):E3.

2016

Initial Clinical Status and Spot Sign Are Associated with Intraoperative Aneurysm Rupture in Patients Undergoing Surgical Clipping for Aneurysmal Subarachnoid Hemorrhage
Burkhardt J, Neidert M, Mohme M, Seifert B, Regli L, Bozinov O
J NEUROL SURG PART A. 2016;77(2):130-8.

Secretory Meningiomas: Characteristic Features and Clinical Management of a Unique Subgroup
Mohme M, Emami P, Matschke J, Regelsberger J, Westphal M, Eicker S
NEUROSURG CLIN N AM. 2016;27(2):181-7.

Secretory Meningiomas: Increased Prevalence of Seizures Secondary to Edema Formation in a Rare Histologic Subtype
Mohme M, Emami P, Regelsberger J, Matschke J, Lamszus K, Westphal M, Eicker S
WORLD NEUROSURG. 2016;92:418-25.

The influence of intraoperative resection control modalities on survival following gross total resection of glioblastoma
Neidert M, Hostettler I, Burkhardt J, Mohme M, Held U, Kofmehl R, Eisele G, Woernle C, Regli L, Bozinov O
NEUROSURG REV. 2016;39(3):401-9.

2014

Immunological challenges for peptide-based immunotherapy in glioblastoma
Mohme M, Neidert M, Regli L, Weller M, Martin R
CANCER TREAT REV. 2014;40(2):248-58.

2013

HLA-DR15-derived self-peptides are involved in increased autologous T cell proliferation in multiple sclerosis.
Mohme M, Hotz C, Stevanovic S, Binder T, Lee J, Okoniewski M, Eiermann T, Sospedra M, Rammensee H, Martin R
BRAIN. 2013;136(Pt 6):1783-1798.

2012

Dry beriberi mimicking Guillain-Barre syndrome as the first presenting sign of thiamine deficiency
Faigle R, Mohme M, Levy M
EUR J NEUROL. 2012;19(2):e14-5.

Letzte Aktualisierung aus dem FIS: 23.05.2024 - 00:51 Uhr