Marc Lütgehetmann
Dr. med.
Marc Lütgehetmann
  • 1.Arbeitsbereich
Sprachen
Deutsch (Muttersprache)
Englisch

Tätigkeitsschwerpunkte

Publikationen

Zurück
  • 2022
  • 2021
  • 2020
  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • 2011
  • 2010
  • 2008
  • 2007
  • 2006
  • 2005
Vor

Infant immunity against viral infections is advanced by the placenta-dependent vertical transfer of maternal antibodies
Albrecht M, Pagenkemper M, Wiessner C, Spohn M, Lütgehetmann M, Jacobsen H, Gabriel G, Zazara-Giannou D, Haertel C, Hecher K, Diemert A, Arck P
VACCINE. 2022;40(11):1563-1571.

Therapeutic shutdown of HBV transcripts promotes reappearance of the SMC5/6 complex and silencing of the viral genome in vivo
Allweiss L, Giersch K, Pirosu A, Volz T, Muench R, Beran R, Urban S, Javanbakht H, Fletcher S, Lütgehetmann M, Dandri-Petersen M
GUT. 2022;71(2):372-381.

Detection of human herpes virus 6 DNA and chromosomal integration after allogeneic hematopoietic stem cell transplantation: a retrospective single center analysis
Berneking L, Both A, Langebrake C, Aepfelbacher M, Lütgehetmann M, Kröger N, Christopeit M
TRANSPL INFECT DIS. 2022;24(3):e13836.

Evaluation of a syndromic panel polymerase chain reaction (spPCR) assay for the diagnosis of device associated bone and joint infections (BJI)
Berneking L, Haas M, Frielinghaus L, Berinson B, Lütgehetmann M, Christner M, Aepfelbacher M, Gerlach U, Seide K, Both A, Rohde H
INT J INFECT DIS. 2022;116:283-288.

Mucha-Habermann disease: a pediatric case report and proposal of a risk score
Blohm M, Ebenebe C, Rau C, Escherich C, Johannsen J, Escherich G, Driemeyer J, Nagel P, Kobbe R, Lütgehetmann M, Lennartz M, Booken N, Schneider S, Singer D
INT J DERMATOL. 2022;61(4):401-409.

Clinical efficacy and in vitro neutralization capacity of monoclonal antibodies for severe acute respiratory syndrome coronavirus 2 delta and omicron variants
Brehm T, Pfefferle S, von Possel R, Karolyi M, Zoufaly A, Wichmann D, Kobbe R, Emmerich P, Nörz D, Aepfelbacher M, Schulze Zur Wiesch J, Addo M, Schmiedel S, Lütgehetmann M
J MED VIROL. 2022;94(10):5038-5043.

Three Separate Spike Antigen Exposures by COVID-19 Vaccination or SARS-CoV-2 Infection Elicit Strong Humoral Immune Responses in Healthcare Workers
Brehm T, Ullrich F, Thompson M, Küchen J, Schwinge D, Spier A, Huber S, Knobloch J, Aepfelbacher M, Addo M, Lohse A, Lütgehetmann M, Schulze Zur Wiesch J
VACCINES-BASEL. 2022;10(7):.

High burden and diversity of carbapenemase-producing Enterobacterales observed in wastewater of a tertiary care hospital in Germany
Carlsen L, Büttner H, Christner M, Franke G, Indenbirken D, Knobling B, Lütgehetmann M, Knobloch J
INT J HYG ENVIR HEAL. 2022;242:.

Integration of sequencing and epidemiological data for surveillance of SARS-CoV-2 infections in a tertiary-care hospital
Czech-Sioli M, Günther T, Robitaille A, Roggenkamp H, Büttner H, Indenbirken D, Christner M, Lütgehetmann M, Knobloch J, Aepfelbacher M, Grundhoff A, Fischer N
CLIN INFECT DIS. 2022 [Epub ahead of print].

SARS-CoV-2 vaccination response in patients with autoimmune hepatitis and autoimmune cholestatic liver disease
Duengelhoef P, Hartl J, Rüther D, Steinmann S, Brehm T, Weltzsch J, Glaser F, Schaub G, Sterneck M, Sebode M, Weiler-Normann C, Addo M, Lütgehetmann M, Haag F, Schramm C, Schulze Zur Wiesch J, Lohse A
UNITED EUR GASTROENT. 2022;10(3):319-329.

Long-term antibody response to SARS-CoV-2 in children
Dunay G, Barroso M, Woidy M, Danecka M, Engels G, Hermann K, Neumann F, Paul K, Beime J, Escherich G, Fehse K, Grinstein L, Haniel F, Haupt L, Hecher L, Kehl T, Kemen C, Kemper M, Kobbe R, Kohl A, Klokow T, Nörz D, Olfe J, Schlenker F, Schmiesing J, Schrum J, Sibbertsen F, Stock P, Tiede S, Vettorazzi E, Zazara D, Zapf A, Lütgehetmann M, Oh J, Mir T, Muntau A, Gersting S
2022.

Natural killer cell-mediated ADCC in SARS-CoV-2-infected individuals and vaccine recipients
Hagemann K, Riecken K, Jung J, Hildebrandt H, Menzel S, Bunders M, Fehse B, Koch-Nolte F, Heinrich F, Peine S, Schulze Zur Wiesch J, Brehm T, Addo M, Lütgehetmann M, Altfeld M
EUR J IMMUNOL. 2022;52(8):1297-1307.

Analysis of the humoral and cellular response after the third COVID-19 vaccination in patients with autoimmune hepatitis
Hartl J, Rüther D, Duengelhoef P, Brehm T, Steinmann S, Weltzsch J, Glaser F, Sterneck M, Sebode M, Weiler-Normann C, Lütgehetmann M, Schaub G, Haag F, Schramm C, Schulze Zur Wiesch J, Lohse A
LIVER INT. 2022 [Epub ahead of print].

Correction: Broadly directed SARS-CoV-2-specific CD4+ T cell response includes frequently detected peptide specificities within the membrane and nucleoprotein in patients with acute and resolved COVID-19
Heide J, Schulte S, Kohsar M, Brehm T, Herrmann M, Karsten H, Marget M, Peine S, Johansson A, Sette A, Lütgehetmann M, Kwok W, Sidney J, Schulze Zur Wiesch J
PLOS PATHOG. 2022;18(1):.

Dying of VOC-202012/01 - multimodal investigations in a death case of the SARS-CoV-2 variant
Heinrich F, Romich C, Zimmermann T, Kniep I, Fitzek A, Steurer S, Glatzel M, Nörz D, Günther T, Czech-Sioli M, Fischer N, Grundhoff A, Lütgehetmann M, Ondruschka B
INT J LEGAL MED. 2022;136(1):193-202.

Tecovirimat therapy for severe monkeypox infection: Longitudinal assessment of viral titers and clinical response pattern-A first case-series experience
Hermanussen L, Grewe I, Tang H, Nörz D, Bal L, Pfefferle S, Unger S, Hoffmann C, Berzow D, Kohsar M, Aepfelbacher M, Lohse A, Addo M, Lütgehetmann M, Schulze Zur Wiesch J, Schmiedel S
J MED VIROL. 2022 [Epub ahead of print].

Peptide microarrays coupled to machine learning reveal individual epitopes from human antibody responses with neutralizing capabilities against SARS-CoV-2
Hotop S, Reimering S, Shekhar A, Asgari E, Beutling U, Dahlke C, Fathi A, Khan F, Lütgehetmann M, Ballmann R, Gerstner A, Tegge W, Cicin-Sain L, Bilitewski U, McHardy A, Brönstrup M
EMERG MICROBES INFEC. 2022;11(1):1037-1048.

Mechanisms of CD8+ T cell failure in chronic hepatitis E virus infection
Kemming J, Gundlach S, Panning M, Huzly D, Huang J, Lütgehetmann M, Fischer N, Neumann-Haefelin C
J HEPATOL. 2022;77(4):978-990.

Vertical anti-SARS-CoV-2 monoclonal antibody transfer from mothers to HIV-exposed and unexposed infants
Kobbe R, Schulze-Sturm U, Kurnaz P, Rau C, Tallarek A, Lütgehetmann M, Jordan S, Schmiedel S
AIDS. 2022;36(11):1613-1615.

Comparing susceptibility and contagiousness in concurrent outbreaks with a non-VOC and the VOC SARS-CoV-2 variant B.1.1.7 in daycare centers in Hamburg, Germany
Nakel J, Robitaille A, Günther T, Rosenau L, Czech-Sioli M, Plenge-Bönig A, Bühler S, Wille A, Jakubowski E, Pruskil S, Wahlen M, Indenbirken D, Nörz D, Lütgehetmann M, Aepfelbacher M, Grundhoff A, Grolle B, Fischer N
INT J HYG ENVIR HEAL. 2022;240:.

Clinical Evaluation of a Fully-Automated High-Throughput Multiplex Screening-Assay to Detect and Differentiate the SARS-CoV-2 B.1.1.529 (Omicron) and B.1.617.2 (Delta) Lineage Variants
Nörz D, Grunwald M, Tang H, Weinschenk C, Günther T, Robitaille A, Giersch K, Fischer N, Grundhoff A, Aepfelbacher M, Pfefferle S, Lütgehetmann M
VIRUSES-BASEL. 2022;14(3):.

Evidence of surface contamination in hospital rooms occupied by patients infected with monkeypox, Germany, June 2022
Nörz D, Pfefferle S, Brehm T, Franke G, Grewe I, Knobling B, Aepfelbacher M, Huber S, Klupp E, Jordan S, Addo M, Schulze Zur Wiesch J, Schmiedel S, Lütgehetmann M, Knobloch J
EUROSURVEILLANCE. 2022;27(26):.

Anti-SARS-CoV-2 antibodies in breast milk during lactation after infection or vaccination: A cohort study
Olearo F, Radmanesh L, Felber N, von Possel R, Emmerich P, Pekarek N, Pfefferle S, Nörz D, Hansen G, Diemert A, Aepfelbacher M, Hecher K, Lütgehetmann M, Arck P, Tallarek A
J REPROD IMMUNOL. 2022;153:.

The effects of SARS-CoV-2 virus type and of vaccination status on causes of death over the course of the COVID-19 pandemic
Paparoupa M, Schröder A, Braunsteiner J, Addo M, Lütgehetmann M, Roedl K, Kluge S, Ondruschka B, Wichmann D
DTSCH ARZTEBL INT. 2022;2022(119):607-608.

Specific CD4+ T Cell Responses to Ancestral SARS-CoV-2 in Children Increase With Age and Show Cross-Reactivity to Beta Variant
Paul K, Sibbertsen F, Weiskopf D, Lütgehetmann M, Barroso M, Danecka M, Glau L, Hecher L, Hermann K, Kohl A, Oh J, Wiesch J, Sette A, Tolosa E, Vettorazzi E, Woidy M, Zapf A, Zazara D, Mir T, Muntau A, Gersting S, Dunay G
FRONT IMMUNOL. 2022;13:867577.

SARS-CoV2-specific humoral and T-cell immune response after second vaccination in liver cirrhosis and transplant patients
Ruether D, Schaub G, Duengelhoef P, Haag F, Brehm T, Fathi A, Wehmeyer M, Jahnke-Triankowski J, Mayer L, Hoffmann A, Fischer L, Addo M, Lütgehetmann M, Lohse A, Schulze Zur Wiesch J, Sterneck M
CLIN GASTROENTEROL H. 2022;20(1):162-172.e9.

Risk factors for poor humoral response to primary and booster SARS-CoV-2 vaccination in hematologic and oncological outpatients-COVIDOUT study
Schönlein M, Wrage V, Ghandili S, Mellinghoff S, Brehm T, Leypoldt L, Utz N, Schrader R, Alsdorf W, Börschel N, Bußmann L, Schönrock M, Perlick D, Schön G, Verpoort K, Lütgehetmann M, Schulze Zur Wiesch J, Weisel K, Bokemeyer C, Schafhausen P, Sinn M
CANCER CELL. 2022;40(6):581-583.

Impact of Oral Rinsing with Octenidine Based Solution on SARS-CoV-2 Loads in Saliva of Infected Patients an Exploratory Study
Smeets R, Pfefferle S, Büttner H, Knobloch J, Lütgehetmann M
INT J ENV RES PUB HE. 2022;19(9):.

OP03.03: Factors influencing transplacental transmission of IgG antibodies providing newborns with maternal passive immunity after COVID-19 in pregnancy
Tallarek A, Hollwitz B, Lütgehetmann M, Arck P, Diemert A, Hecher K
ULTRASOUND OBST GYN. 2022;58(S1):65-66.

First report from the German COVID-19 autopsy registry
von Stillfried S, Bülow R, Röhrig R, Boor P
LANCET REG HEALTH-EU. 2022;15:.

Intracranial hemorrhage in COVID-19 patients during extracorporeal membrane oxygenation for acute respiratory failure: a nationwide register study report
von Stillfried S, Bülow R, Röhrig R, Meybohm P, Boor P
CRIT CARE. 2022;26(1):.

Molecular consequences of SARS-CoV-2 liver tropism
Wanner N, Andrieux G, Badia-I-Mompel P, Edler C, Pfefferle S, Lindenmeyer M, Schmidt-Lauber C, Czogalla J, Wong M, Okabayashi Y, Braun F, Lütgehetmann M, Meister E, Lu S, Noriega M, Günther T, Grundhoff A, Fischer N, Bräuninger H, Lindner D, Westermann D, Haas F, Roedl K, Kluge S, Addo M, Huber S, Lohse A, Reiser J, Ondruschka B, Sperhake J, Saez-Rodriguez J, Boerries M, Hayek S, Aepfelbacher M, Scaturro P, Puelles V, Huber T
NAT METAB. 2022;4(3):310-319.

Lack of Evidence of Hepatitis E Virus Infections in a Cohort of Boars and Deer Species in a Game Reserve in Northern Germany
Westphal T, Delling M, Mader M, Ackermann C, Horvatits T, Lütgehetmann M, Schulze zur Wiesch J, Pischke S, Beisel C
Zoonotic Diseases. 2022;2(4):228-233.

New Safety Aspects in Corneal Donation-Studies on SARS-CoV-2-Positive Corneal Donors
Wille D, Heinzelmann J, Kehlen A, Lütgehetmann M, Nörz D, Siebolts U, Mueller A, Karrasch M, Hofmann N, Viestenz A, Börgel M, Kuhn F, Viestenz A
J CLIN MED. 2022;11(12):.

Fatal COVID-19 in a Child with Persistence of SARS-CoV-2 Despite Extensive Multidisciplinary Treatment: A Case Report
Apostolidou S, Harbauer T, Lasch P, Biermann D, Hempel M, Lütgehetmann M, Pfefferle S, Herrmann J, Rüffer A, Reinshagen K, Kozlik-Feldmann R, Gieras A, Kniep I, Oh J, Singer D, Ebenebe C, Kobbe R
CHILDREN-BASEL. 2021;8(7):.

HEV-Associated Neuralgic Amyotrophy : A Multicentric Case Series
Bannasch J, Berger B, Schwartkopp C, Berning M, Goetze O, Panning M, Fritz-Weltin M, Trendelenburg G, Gelderblom M, Lütgehetmann M, Stute F, Horvatits T, Dirks M, Antoni C, Behrendt P, Pischke S
PATHOGENS. 2021;10(6):.

Usefulness of Biofire FilmArray BCID2 for blood culture processing in clinical practice
Berinson B, Both A, Berneking L, Christner M, Lütgehetmann M, Aepfelbacher M, Rohde H
J CLIN MICROBIOL. 2021;59(8):e0054321.

Performance of a loop-mediated isothermal amplification assay (Isoplex CRE-ART) to detect common carbapenemase-encoding genes in Gram-negative bacteria
Berneking L, Asar L, Both A, Berinson B, Aepfelbacher M, Lütgehetmann M, Rohde H
J MED MICROBIOL. 2021;70(7):.

Performance of the BD Phoenix CPO detect assay for detection and classification of carbapenemase-producing organisms
Berneking L, Both A, Berinson B, Hoffmann A, Lütgehetmann M, Aepfelbacher M, Rohde H
EUR J CLIN MICROBIOL. 2021;40(5):979-985.

Lower Levels of Transaminases but Higher Levels of Serum Creatinine in Patients with Acute Hepatitis E in Comparison to Patients with Hepatitis A
Brehm T, Mazaheri O, Horvatits T, Lütgehetmann M, Schulze Zur Wiesch J, Lohse A, Polywka S, Pischke S
PATHOGENS. 2021;10(1):60.

SARS-CoV-2 Reinfection in a Healthcare Worker Despite the Presence of Detectable Neutralizing Antibodies
Brehm T, Pfefferle S, von Possel R, Kobbe R, Nörz D, Schmiedel S, Grundhoff A, Olearo F, Emmerich P, Robitaille A, Günther T, Braun P, Andersen G, Knobloch J, Addo M, Lohse A, Aepfelbacher M, Fischer N, Schulze Zur Wiesch J, Lütgehetmann M
VIRUSES-BASEL. 2021;13(4):.

Seroprevalence of SARS-CoV-2 antibodies among hospital workers in a German tertiary care center: A sequential follow-up study
Brehm T, Schwinge D, Lampalzer S, Schlicker V, Küchen J, Thompson M, Ullrich F, Huber S, Schmiedel S, Addo M, Lütgehetmann M, Knobloch J, Schulze Zur Wiesch J, Lohse A
INT J HYG ENVIR HEAL. 2021;232:.

Low SARS-CoV-2 infection rates and high vaccine-induced immunity among German healthcare workers at the end of the third wave of the COVID-19 pandemic
Brehm T, Thompson M, Ullrich F, Schwinge D, Addo M, Spier A, Knobloch J, Aepfelbacher M, Lohse A, Lütgehetmann M, Schulze Zur Wiesch J
INT J HYG ENVIR HEAL. 2021;238:.

Comparison of clinical characteristics and disease outcome of COVID-19 and seasonal influenza
Brehm T, van der Meirschen M, Hennigs A, Roedl K, Jarczak D, Wichmann D, Frings D, Nierhaus A, Oqueka T, Fiedler W, Christopeit M, Kraef C, Schultze A, Lütgehetmann M, Addo M, Schmiedel S, Kluge S, Schulze Zur Wiesch J
SCI REP-UK. 2021;11(1):.

Presence of SARS-CoV-2 RNA in the Cornea of Viremic Patients With COVID-19
Casagrande M, Fitzek A, Spitzer M, Püschel K, Glatzel M, Krasemann S, Nörz D, Lütgehetmann M, Pfefferle S, Schultheiss M
JAMA OPHTHALMOL. 2021;139(4):383-388.

Innate immunity in hepatitis B and D virus infection: consequences for viral persistence, inflammation, and T cell recognition
Dandri M, Bertoletti A, Lütgehetmann M
SEMIN IMMUNOPATHOL. 2021;43(4):535-548.

Prospective postmortem evaluation of 735 consecutive SARS-CoV-2-associated death cases
Fitzek A, Schädler J, Dietz E, Ron A, Gerling M, Kammal A, Lohner L, Falck C, Möbius D, Goebels H, Gerberding A, Schröder A, Sperhake J, Klein A, Fröb D, Mushumba H, Wilmes S, Anders S, Kniep I, Heinrich F, Langenwalder F, Meißner K, Lange P, Zapf A, Püschel K, Heinemann A, Glatzel M, Matschke J, Aepfelbacher M, Lütgehetmann M, Steurer S, Thorns C, Edler C, Ondruschka B
SCI REP-UK. 2021;11(1):19342.

An automated room disinfection system using ozone is highly active against surrogates for SARS-CoV-2
Franke G, Knobling B, Brill F, Becker B, Klupp E, Belmar Campos C, Pfefferle S, Lütgehetmann M, Knobloch J
J HOSP INFECT. 2021;112:108-113.

Clinical evaluation of a laboratory-developed quantitative BK virus-PCR assay using the cobas® omni Utility Channel
Fritzsche A, Berneking L, Nörz D, Reucher S, Fischer N, Roggenkamp H, Aepfelbacher M, Rohde H, Pfefferle S, Lütgehetmann M
J VIROL METHODS. 2021;290:114093.

Low incidence of COVID-19 in a prospective cohort of patients with liver cirrhosis and hepatocellular carcinoma treated at a tertiary medical center during the 2020 pandemic
Fründt T, Kuballa L, Lütgehetman M, Nörz D, Arend H, Brehm T, Schulze Zur Wiesch J, Horvatits T, Horvatits K, Huber S, Wege H, Kluwe J
PLOS ONE. 2021;16(12):e0258450.

Post-Vaccination Anti-SARS-CoV-2-Antibody Response in Patients with Multiple Myeloma Correlates with Low CD19+ B-Lymphocyte Count and Anti-CD38 Treatment
Ghandili S, Schönlein M, Lütgehetmann M, Wiesch J, Becher H, Bokemeyer C, Sinn M, Weisel K, Leypoldt L
CANCERS. 2021;13(15):.

Lymphocytopenia and Anti-CD38 Directed Treatment Impact the Serological SARS-CoV-2 Response after Prime Boost Vaccination in Patients with Multiple Myeloma
Ghandili S, Schönlein M, Wiessner C, Becher H, Lütgehetmann M, Brehm T, Wiesch J, Bokemeyer C, Sinn M, Weisel K, Leypoldt L
J CLIN MED. 2021;10(23):.

Murine hepatocytes do not support persistence of Hepatitis D Virus mono-infection in vivo
Giersch K, Hermanussen L, Volz T, Kah J, Allweiss L, Casey J, Sureau C, Dandri M, Lütgehetmann M
LIVER INT. 2021;41(2):410-419.

Strong Replication Interference Between Hepatitis Delta Viruses in Human Liver Chimeric Mice
Giersch K, Hermanussen L, Volz T, Volmari A, Allweiss L, Sureau C, Casey J, Huang J, Fischer N, Lütgehetmann M, Dandri M
FRONT MICROBIOL. 2021;12:671466.

Broadly directed SARS-CoV-2-specific CD4+ T cell response includes frequently detected peptide specificities within the membrane and nucleoprotein in patients with acute and resolved COVID-19
Heide J, Schulte S, Kohsar M, Brehm T, Herrmann M, Karsten H, Marget M, Peine S, Johansson A, Sette A, Lütgehetmann M, Kwok W, Sidney J, Schulze Zur Wiesch J
PLOS PATHOG. 2021;17(9):.

Polymicrobial enteric infections in african infants with diarrhoea - Results from a longitudinal prospective case-control study
Heinemann M, Strauchs C, Lütgehetmann M, Aepfelbacher M, Klupp E, Owusu-Dabo E, Rolling T, Cramer J, Vinnemeier C
CLIN MICROBIOL INFEC. 2021;27(12):1792-1798.

Postmortem Stability of SARS-CoV-2 in Nasopharyngeal Mucosa
Heinrich F, Meißner K, Langenwalder F, Püschel K, Hoffmann A, Lütgehetmann M, Aepfelbacher M, Bibiza-Freiwald E, Pfefferle S, Heinemann A
EMERG INFECT DIS. 2021;27(1):329-331.

SARS-CoV-2 Blood RNA Load Predicts Outcome in Critically Ill COVID-19 Patients
Heinrich F, Nentwich M, Bibiza-Freiwald E, Nörz D, Roedl K, Christner M, Hoffmann A, Olearo F, Kluge S, Aepfelbacher M, Wichmann D, Lütgehetmann M, Pfefferle S
OPEN FORUM INFECT DI. 2021;8(11):.

Hepatitis E virus persists in the ejaculate of chronically infected men
Horvatits T, Wißmann J, Johne R, Groschup M, Gadicherla A, Wiesch J, Eiden M, Todt D, Reimer R, Dähnert L, Schöbel A, Horvatits K, Lübke R, Wolschke C, Ayuk F, Rybczynski M, Lohse A, Addo M, Herker E, Lütgehetmann M, Steinmann E, Pischke S
J HEPATOL. 2021;75(1):55-63.

KIR3DS1 directs NK cell-mediated protection against human adenovirus infections
Jung J, Ching W, Baumdick M, Hofmann-Sieber H, Bosse J, Koyro T, Möller K, Wegner L, Niehrs A, Russu K, Ohms M, Zhang W, Ehrhardt A, Duisters K, Spierings E, Hölzemer A, Körner C, Jansen S, Peine S, Königs I, Lütgehetmann M, Perez D, Reinshagen K, Lindemans C, Altfeld M, Belderbos M, Dobner T, Bunders M
SCI IMMUNOL. 2021;6(63):.

SARS-CoV-2-Zufallsentdeckungen bei Hamburger Todesfällen: ein epidemiologisches Monitoring während des dynamischen Infektionsgeschehens im Frühjahr 2020
Klein A, Langenwalder F, Heinrich F, Meißner K, Schröder A, Püschel K, Ondruschka B, Lütgehetmann M, Heinemann A
RECHTSMEDIZIN. 2021;31:427-433.

Evaluation of a fully automated high-throughput SARS-CoV-2 multiplex qPCR assay with built-in screening functionality for del-HV69/70- and N501Y variants such as B.1.1.7
Nörz D, Grunwald M, Olearo F, Fischer N, Aepfelbacher M, Pfefferle S, Lütgehetmann M
J CLIN VIROL. 2021;141:.

Rapid Automated Screening for SARS-CoV-2 B.1.617 Lineage Variants (Delta/Kappa) through a Versatile Toolset of qPCR-Based SNP Detection
Nörz D, Grunwald M, Tang H, Olearo F, Günther T, Robitaille A, Fischer N, Grundhoff A, Aepfelbacher M, Pfefferle S, Lütgehetmann M
DIAGNOSTICS. 2021;11(10):.

Clinical evaluation of a fully automated, laboratory-developed multiplex RT-PCR assay integrating dual-target SARS-CoV-2 and influenza A/B detection on a high-throughput platform
Nörz D, Hoffmann A, Aepfelbacher M, Pfefferle S, Lütgehetmann M
J MED MICROBIOL. 2021;70(2):.

Multicenter Evaluation of a Fully Automated High-Throughput SARS-CoV-2 Antigen Immunoassay
Nörz D, Olearo F, Perisic S, Bauer M, Riester E, Schneider T, Schönfeld K, Laengin T, Lütgehetmann M
INFECT DIS THER. 2021;10(4):2371-2379.

Modifying a Diagnostic SARS-CoV-2 Spike PCR to Turn a Del69/70 Dropout into a Discriminatory On-Target Assay
Nörz D, Pfefferle S, Grunwald M, Fischer N, Aepfelbacher M, Lütgehetmann M
J MOL DIAGN. 2021;23(6):777-778.

Handling and accuracy of four rapid antigen tests for the diagnosis of SARS-CoV-2 compared to RT-qPCR
Olearo F, Nörz D, Heinrich F, Sutter J, Roedl K, Schultze A, Wiesch J, Braun P, Oestereich L, Kreuels B, Wichmann D, Aepfelbacher M, Pfefferle S, Lütgehetmann M
J CLIN VIROL. 2021;137:.

Clinical performance and accuracy of a qPCR-based SARS-CoV-2 mass-screening workflow for healthcare-worker surveillance using pooled self-sampled gargling solutions: a cross-sectional study
Olearo F, Nörz D, Hoffman A, Grunwald M, Gatzemeyer K, Christner M, Both A, Campos C, Braun P, Andersen G, Pfefferle S, Zapf A, Aepfelbacher M, Knobloch J, Lütgehetmann M
J INFECTION. 2021;83(5):589-593.

Multiorgan tropism of SARS-CoV-2 lineage B.1.1.7
Ondruschka B, Heinrich F, Lindenmeyer M, Edler C, Möbius D, Czogalla J, Heinemann A, Braun F, Aepfelbacher M, Lütgehetmann M, Huber T
INT J LEGAL MED. 2021;135(6):2347-2349.

SARS Coronavirus-2 variant tracing within the first Coronavirus Disease 19 clusters in northern Germany
Pfefferle S, Günther T, Kobbe R, Czech-Sioli M, Nörz D, Santer R, Oh J, Kluge S, Oestereich L, Peldschus K, Indenbirken D, Huang J, Grundhoff A, Aepfelbacher M, Knobloch J, Lütgehetmann M, Fischer N
CLIN MICROBIOL INFEC. 2021;27(1):130.e5-130.e8.

Clinical establishment of a laboratory developed quantitative HDV PCR assay on the cobas6800 high-throughput system
Pflüger L, Nörz D, Volz T, Giersch K, Giese A, Goldmann N, Glebe D, Bockmann J, Pfefferle S, Dandri M, Schulze Zur Wiesch J, Lütgehetmann M
JHEP REP. 2021;3(6):.

Hepatitis delta virus propagation enabled by hepatitis C virus - scientifically intriguing; but is it relevant to clinical practice?
Pflüger L, Schulze Zur Wiesch J, Polywka S, Lütgehetmann M
J VIRAL HEPATITIS. 2021;28(1):213-216.

Viral Dynamics of SARS-CoV-2 in Critically Ill Allogeneic Hematopoietic Stem Cell Transplant Recipients and Immunocompetent Patients with COVID-19
Roedl K, Heidenreich S, Pfefferle S, Jarczak D, Urbanowicz T, Nörz D, Aepfelbacher M, Kröger N, Kluge S, Lütgehetmann M, Christopeit M, Wichmann D
AM J RESPIR CRIT CARE MED. 2021;203(2):242-245.

Severe liver dysfunction complicating course of COVID-19 in the critically ill: multifactorial cause or direct viral effect?
Roedl K, Jarczak D, Drolz A, Wichmann D, Boenisch O, de Heer G, Burdelski C, Frings D, Sensen B, Nierhaus A, Lütgehetmann M, Kluge S, Fuhrmann V
ANN INTENSIVE CARE. 2021;11(1):.

The handling of SARS-CoV-2 associated deaths - infectivity of the body
Schröder A, Edler C, Ondruschka B, Püschel K, Schädler J, Heinemann A, Heinrich F, Lütgehetmann M, Pfefferle S, Aepfelbacher M, Fitzek A, Sperhake J
FORENSIC SCI MED PAT. 2021;17(3):411-418.

Inefficient Placental Virus Replication and Absence of Neonatal Cell-Specific Immunity Upon Sars-CoV-2 Infection During Pregnancy
Tallarek A, Urbschat C, Fonseca Brito L, Stanelle-Bertram S, Krasemann S, Frascaroli G, Thiele K, Wieczorek A, Felber N, Lütgehetmann M, Markert U, Hecher K, Brune W, Stahl F, Gabriel G, Diemert A, Arck P
FRONT IMMUNOL. 2021;12:698578.

B cell analysis in SARS‐CoV‐2 versus malaria: Increased frequencies of plasmablasts and atypical memory B cells in COVID‐19
Wildner N, Ahmadi P, Schulte S, Brauneck F, Kohsar M, Lütgehetmann M, Beisel C, Addo M, Haag F, Schulze zur Wiesch J
J LEUKOCYTE BIOL. 2021;109(1):77-90.

Control of SARS-CoV-2 infection in rituximab-treated neuroimmunological patients
Woo M, Steins D, Häußler V, Kohsar M, Haag F, Elias-Hamp B, Heesen C, Lütgehetmann M, Schulze Zur Wiesch J, Friese M
J NEUROL. 2021;268(1):5-7.

Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients
Zhao Y, Kilian C, Turner J, Bosurgi L, Roedl K, Bartsch P, Gnirck A, Cortesi F, Schultheiß C, Hellmig M, Enk L, Hausmann F, Borchers A, Wong M, Paust H, Siracusa F, Scheibel N, Herrmann M, Rosati E, Bacher P, Kylies D, Jarczak D, Lütgehetmann M, Pfefferle S, Steurer S, Zur Wiesch J, Puelles V, Sperhake J, Addo M, Lohse A, Binder M, Huber S, Huber T, Kluge S, Bonn S, Panzer U, Gagliani N, Krebs C
SCI IMMUNOL. 2021;6(56):.

High rates of cirrhosis and severe clinical events in patients with HBV/HDV co-infection:longitudinal analysis of a German cohort:longitudinal analysis of a German cohort
Bockmann J, Grube M, Hamed V, von Felden J, Landahl J, Wehmeyer M, Giersch K, Hall M, Murray J, Dandri M, Lüth S, Lohse A, Lütgehetmann M, Schulze Zur Wiesch J
BMC GASTROENTEROL. 2020;20(1):24.

Rapid identification of the vanA/vanB resistance determinant in Enterococcus sp. from blood cultures using the Cepheid Xpert vanA/vanB cartridge system
Both A, Berneking L, Berinson B, Lütgehetmann M, Christner M, Aepfelbacher M, Rohde H
DIAGN MICR INFEC DIS. 2020;96(4):114977.

SARS-CoV-2 renal tropism associates with acute kidney injury
Braun F, Lütgehetmann M, Pfefferle S, Wong M, Carsten A, Lindenmeyer M, Nörz D, Heinrich F, Meißner K, Wichmann D, Kluge S, Gross O, Pueschel K, Schröder A, Edler C, Aepfelbacher M, Puelles V, Huber T
LANCET. 2020;396(10251):597-598.

Risk factors for different intestinal pathogens among patients with traveler's diarrhea: A retrospective analysis at a German travel clinic (2009-2017)
Brehm T, Lütgehetmann M, Tannich E, Addo M, Lohse A, Rolling T, Vinnemeier C
TRAVEL MED INFECT DI. 2020;37:101706.

High effectiveness of multimodal infection control interventions in preventing SARS−CoV−2 infections in healthcare professionals: a prospective longitudinal seroconversion study
Brehm T, Schwinge D, Lampalzer S, Schlicker V, Küchen J, Thompson M, Ullrich F, Huber S, Schmiedel S, Addo M, Lütgehetmann M, Knobloch J, Schulze zur Wiesch J, Lohse A
medRxiv BMJ. 2020.

Correction to:Dying with SARS-CoV-2 infection-an autopsy study of the first consecutive 80 cases in Hamburg, Germany
Edler C, Schröder A, Aepfelbacher M, Fitzek A, Heinemann A, Heinrich F, Klein A, Langenwalder F, Lütgehetmann M, Meißner K, Püschel K, Schädler J, Steurer S, Mushumba H, Sperhake J
INT J LEGAL MED. 2020;134(5):1977.

Dying with SARS-CoV-2 infection-an autopsy study of the first consecutive 80 cases in Hamburg, Germany
Edler C, Schröder A, Aepfelbacher M, Fitzek A, Heinemann A, Heinrich F, Klein A, Langenwalder F, Lütgehetmann M, Meißner K, Püschel K, Schädler J, Steurer S, Mushumba H, Sperhake J
INT J LEGAL MED. 2020;134(4):1275-1284.

Detection of C. difficile toxin as a model assay for performing fully automated high-throughput RT-PCR on clinical stool samples
Eigner U, Nörz D, Reucher S, Furrer J, Sun J, Chu K, Kolb M, Hefner N, Pfefferle S, Lütgehetmann M
J MICROBIOL METH. 2020;172:105882.

Evidence for systematic autopsies in COVID-19 positive deceased:Case report of the first German investigated COVID-19 death
Fitzek A, Sperhake J, Edler C, Schröder A, Heinemann A, Heinrich F, Ron A, Mushumba H, Lütgehetmann M, Püschel K
RECHTSMEDIZIN. 2020;1-6.

Autoantibodies to intracellular "rods and rings" structures in two patients with autoimmune hepatitis treated with azathioprine
Galaski J, Koop A, Lütgehetmann M, Lohse A, Weiler-Normann C
AUTOIMMUNITY. 2020;53(6):362-365.

Challenges in treatment of patients with acute leukemia and COVID-19: a series of 12 patients
Ghandili S, Pfefferle S, Roedl K, Sonnemann P, Karagiannis P, Boenisch O, Kluge S, Schmiedel S, Ittrich H, Rohde H, Lütgehetmann M, Weisel K, Bokemeyer C, Wichmann D, Fiedler W, Jarczak D, Modemann F
BLOOD ADV. 2020;4(23):5936-5941.

Antibiotic sensitivity in correlation to the origin of secondary peritonitis: a single center analysis
Grotelüschen R, Heidelmann L, Lütgehetmann M, Melling N, Reeh M, Ghadban T, Dupree A, Izbicki J, Bachmann K
SCI REP-UK. 2020;10(1):18588.

Germany's first COVID-19 deceased:a 59-year-old man presenting with diffuse alveolar damage due to SARS-CoV-2 infection
Heinrich F, Sperhake J, Heinemann A, Mushumba H, Lennartz M, Nörz D, Glatzel M, Lütgehetmann M, Püschel K
VIRCHOWS ARCH. 2020;477(3):335-339.

Significance of Anti-Nuclear Antibodies and Cryoglobulins in Patients with Acute and Chronic HEV Infection
Horvatits T, Schulze Zur Wiesch J, Polywka S, Buescher G, Lütgehetmann M, Hussey E, Horvatits K, Peine S, Haag F, Addo M, Lohse A, Weiler-Normann C, Pischke S
PATHOGENS. 2020;9(9):.

No link between male infertility and HEV genotype 3 infection
Horvatits T, Varwig-Janssen D, Schulze Zur Wiesch J, Lübke R, Reucher S, Frerk S, Addo M, Schneider S, Lohse A, Luetgehetmann M, Pischke S
GUT. 2020;69(6):1150-1151.

Targeting Endothelial Dysfunction in Eight Extreme-Critically Ill Patients with COVID-19 Using the Anti-Adrenomedullin Antibody Adrecizumab (HAM8101)
Karakas M, Jarczak D, Becker M, Roedl K, Addo M, Hein F, Bergmann A, Zimmermann J, Simon T, Marx G, Lütgehetmann M, Nierhaus A, Kluge S
BIOMOLECULES. 2020;10(8):.

Sustained response after remdesivir and convalescent plasma therapy in a B-cell depleted patient with protracted COVID-19
Malsy J, Veletzky L, Heide J, Hennigs A, Gil-Ibanez I, Stein A, Lütgehetmann M, Rosien U, Jasper D, Peine S, Hiller J, Haag F, Schmiedel S, Huber S, Jordan S, Addo M, Schulze Zur Wiesch J
CLIN INFECT DIS. 2020.

Neuropathology of patients with COVID-19 in Germany: a post-mortem case series
Matschke J, Lütgehetmann M, Hagel C, Sperhake J, Schröder A, Edler C, Mushumba H, Fitzek A, Allweiss L, Dandri M, Dottermusch M, Heinemann A, Pfefferle S, Schwabenland M, Sumner Magruder D, Bonn S, Prinz M, Gerloff C, Püschel K, Krasemann S, Aepfelbacher M, Glatzel M
LANCET NEUROL. 2020;19(11):919-929.

Clinical evaluation of a SARS-CoV-2 RT-PCR assay on a fully automated system for rapid on-demand testing in the hospital setting
Nörz D, Fischer N, Schultze A, Kluge S, Mayer-Runge U, Aepfelbacher M, Pfefferle S, Lütgehetmann M
J CLIN VIROL. 2020;128:104390.

Pushing beyond specifications:Evaluation of linearity and clinical performance of the cobas 6800/8800 SARS-CoV-2 RT-PCR assay for reliable quantification in blood and other materials outside recommendations
Nörz D, Frontzek A, Eigner U, Oestereich L, Wichmann D, Kluge S, Fischer N, Aepfelbacher M, Pfefferle S, Lütgehetmann M
J CLIN VIROL. 2020;132:104650.

Implementation of the FilmArray ME panel in laboratory routine using a simple sample selection strategy for diagnosis of meningitis and encephalitis
Pfefferle S, Christner M, Aepfelbacher M, Lütgehetmann M, Rohde H
BMC INFECT DIS. 2020;20(1):170.

Complete Genome Sequence of a SARS-CoV-2 Strain Isolated in Northern Germany
Pfefferle S, Huang J, Nörz D, Indenbirken D, Lütgehetmann M, Oestereich L, Günther T, Grundhoff A, Aepfelbacher M, Fischer N
Microbiol Resour Announc. 2020;9(23):.

Evaluation of a quantitative RT-PCR assay for the detection of the emerging coronavirus SARS-CoV-2 using a high throughput system
Pfefferle S, Reucher S, Nörz D, Lütgehetmann M
EUROSURVEILLANCE. 2020;25(9):.

Clinical evaluation of five different automated SARS-CoV-2 serology assays in a cohort of hospitalized COVID-19 patients
Pflüger L, Bannasch J, Brehm T, Pfefferle S, Hoffmann A, Nörz D, van der Meirschen M, Kluge S, Haddad M, Pischke S, Hiller J, Addo M, Lohse A, Wiesch J, Peine S, Aepfelbacher M, Lütgehetmann M
J CLIN VIROL. 2020;130:104549.

Multiorgan and Renal Tropism of SARS-CoV-2
Puelles V, Lütgehetmann M, Lindenmeyer M, Sperhake J, Wong M, Allweiss L, Chilla S, Heinemann A, Wanner N, Liu S, Braun F, Lu S, Pfefferle S, Schröder A, Edler C, Gross O, Glatzel M, Wichmann D, Wiech T, Kluge S, Pueschel K, Aepfelbacher M, Huber T
NEW ENGL J MED. 2020;383(6):590-592.

Hepatitis Delta Virus Acts as an Immunogenic Adjuvant in Hepatitis B Virus-Infected Hepatocytes
Tham C, Kah J, Tan A, Volz T, Chia A, Giersch K, Ladiges Y, Loglio A, Borghi M, Sureau C, Lampertico P, Lütgehetmann M, Dandri-Petersen M, Bertoletti A
CELL REP MED. 2020;1(4):100060.

Autopsy Findings and Venous Thromboembolism in Patients With COVID-19: A Prospective Cohort Study
Wichmann D, Sperhake J, Lütgehetmann M, Steurer S, Edler C, Heinemann A, Heinrich F, Mushumba H, Kniep I, Schröder A, Burdelski C, de Heer G, Nierhaus A, Frings D, Pfefferle S, Becker H, Bredereke-Wiedling H, de Weerth A, Paschen H, Sheikhzadeh-Eggers S, Stang A, Schmiedel S, Bokemeyer C, Addo M, Aepfelbacher M, Püschel K, Kluge S
ANN INTERN MED. 2020;173(4):268-277.

DAMIAN an open source bioinformatics tool for fast, systematic and cohort based analysis of microorganisms in diagnostic samples
Alawi M, Burkhardt L, Indenbirken D, Reumann K, Christopeit M, Kröger N, Lütgehetmann M, Aepfelbacher M, Fischer N, Grundhoff A
SCI REP-UK. 2019;9(1):16841.

Influence of local epidemiology on the performance of common colistin drug susceptibility testing methods
Asar L, Pfefferle S, Lütgehetmann M, Hoffmann A, Katchanov J, Aepfelbacher M, Rohde H, Maurer F
PLOS ONE. 2019;14(6):e0217468.

Clinical evaluation of multiplex RT-PCR assays for the detection of influenza A/B and respiratory syncytial virus using a high throughput system
Eigner U, Reucher S, Hefner N, Staffa-Peichl S, Kolb M, Betz U, Holfelder M, Spier G, Pfefferle S, Lütgehetmann M
J VIROL METHODS. 2019;269:49-54.

Hepatitis delta virus persists during liver regeneration and is amplified through cell division both in vitro and in vivo
Giersch K, Bhadra O, Volz T, Allweiss L, Riecken K, Fehse B, Lohse A, Petersen J, Sureau C, Urban S, Dandri M, Lütgehetmann M
GUT. 2019;68(1):150-157.

Microbial findings, sensitivity and outcome in patients with postoperative peritonitis a retrospective cohort study
Grotelueschen R, Luetgehetmann M, Erbes J, Heidelmann L, Grupp K, Karstens K, Ghadban T, Reeh M, Izbicki J, Bachmann K
INT J SURG. 2019;70:63-69.

The Clinical Perspective on Hepatitis E
Horvatits T, Schulze Zur Wiesch J, Lütgehetmann M, Lohse A, Pischke S
VIRUSES-BASEL. 2019;11(7):.

Changes in the composition of the upper respiratory tract microbial community in granulomatosis with polyangiitis
Lamprecht P, Fischer N, Huang J, Burkhardt L, Lütgehetmann M, Arndt F, Rolfs I, Kerstein A, Iking-Konert C, Laudien M
J AUTOIMMUN. 2019;97:29-39.

Detection of a Broad Range of Low-Level Major Histocompatibility Complex Class II-Restricted, Hepatitis Delta Virus (HDV)-Specific T-Cell Responses Regardless of Clinical Status
Landahl J, Bockmann J, Scheurich C, Ackermann C, Matzat V, Heide J, Nuurei T, D'Antonio G, von Felden J, Sette A, Peine S, Lohse A, Lütgehetmann M, Marget M, Sidney J, Schulze Zur Wiesch J
J INFECT DIS. 2019;219(4):568-577.

Potential Role for Urine Polymerase Chain Reaction in the Diagnosis of Whipple's Disease
Moter A, Janneck M, Wolters M, Iking-Konert C, Wiessner A, Loddenkemper C, Hartleben B, Lütgehetmann M, Schmidt J, Langbehn U, Janssen S, Geelhaar-Karsch A, Schneider T, Moos V, Rohde H, Kikhney J, Wiech T
CLIN INFECT DIS. 2019;68(7):1089-1097.

Chronic Hepatitis E in Rheumatology and Internal Medicine Patients: A Retrospective Multicenter European Cohort Study
Pischke S, Peron J, von Wulffen M, von Felden J, Höner Zu Siederdissen C, Fournier S, Lütgehetmann M, Iking-Konert C, Bettinger D, Par G, Thimme R, Cantagrel A, Lohse A, Wedemeyer H, de Man R, Mallet V
VIRUSES-BASEL. 2019;11(2):.

Fatal PCR-negative herpes simplex virus-1 encephalitis with GABAA receptor antibodies
Schuster S, Abrante L, Matschke J, Lütgehetmann M, Holst B, Gelderblom M, Braass H, Leypoldt F, Magnus T
NEUROL-NEUROIMMUNOL. 2019;6(6):.

T cell receptor grafting allows virological control of Hepatitis B virus infection
Wisskirchen K, Kah J, Malo A, Asen T, Volz T, Allweiss L, Wettengel J, Lütgehetmann M, Urban S, Bauer T, Dandri M, Protzer U
J CLIN INVEST. 2019;129(7):2932-2945.

Proliferation of primary human hepatocytes and prevention of hepatitis B virus reinfection efficiently deplete nuclear cccDNA in vivo
Allweiss L, Volz T, Giersch K, Kah J, Raffa G, Petersen J, Lohse A, Beninati C, Pollicino T, Urban S, Lütgehetmann M, Dandri M
GUT. 2018;67(3):542-552.

A humanized mouse model of liver fibrosis following expansion of transplanted hepatic stellate cells
Benten D, Kluwe J, Wirth J, Thiele N, Follenzi A, Bhargava K, Palestro C, Koepke M, Tjandra R, Volz T, Lutgehetmann M, Gupta S
LAB INVEST. 2018;98(4):525-536.

Epidemiology, clinical and laboratory features of 24 consecutive cases of leptospirosis at a German infectious disease center.
Brehm T, Schulze zur Wiesch J, Lütgehetmann M, Tappe D, Eisermann P, Lohse A, Addo M, Schmiedel S
INFECTION. 2018;46(6):847-853.

Hepatitis E seroprevalence in the Americas: A systematic review and meta-analysis
Horvatits T, Ozga A, Westhölter D, Hartl J, Manthey C, Lütgehetmann M, Rauch G, Kriston L, Lohse A, Bendall R, Wedemeyer H, Dalton H, Pischke S
LIVER INT. 2018;38(11):1951-1964.

Lack of evidence for human serum albumin as major source of HEV infections
Horvatits T, Westhölter D, Peine S, Schulze Zur Wiesch J, Lohse A, Lütgehetmann M, Pischke S
TRANSFUSION MED. 2018;28(6):470-471.

Efficacy of NVR 3-778, Alone and in Combination With Pegylated Interferon, vs Entecavir in uPA/SCID Mice With Humanized Livers and HBV Infection
Klumpp K, Shimada T, Allweiss L, Volz T, Lütgehetmann M, Hartman G, Flores O, Lam A, Dandri-Petersen M
GASTROENTEROLOGY. 2018;154(3):652-662.e8.

Course of HEV viremia and anti-HEV IgM/IgG response in asymptomatic blood donors
Kraef C, Schlein C, Hiller J, Westhölter D, Denzer U, Horvatits T, Peine S, Lohse A, Lütgehetmann M, Polywka S, Pischke S
J CLIN VIROL. 2018;105:26-30.

Colitis Promotes a Pathological Condition of the Liver in the Absence of Foxp3 Regulatory T Cells
Mathies F, Steffens N, Kleinschmidt D, Stuhlmann F, Huber F, Roy U, Meyer T, Luetgehetmann M, von Petersdorff M, Seiz O, Herkel J, Schramm C, Flavell R, Gagliani N, Krebs C, Panzer U, Abdullah Z, Strowig T, Bedke T, Huber S
J IMMUNOL. 2018;201(12):3558-3568.

A Novel Orally Available Small Molecule That Inhibits Hepatitis B Virus Expression
Mueller H, Wildum S, Luangsay S, Walther J, Lopez A, Tropberger P, Ottaviani G, Lu W, John Parrott N, Zhang J, Schmucki R, Racek T, Hoflack J, Kueng E, Point F, Zhou X, Steiner G, Lütgehetmann M, Rapp G, Volz T, Dandri M, Yang S, Young J, Javanbakht H
J HEPATOL. 2018;68(3):412-420.

Hepatitis E: Still Waters Run Deep
von Wulffen M, Westhölter D, Lütgehetmann M, Pischke S
J Clin Transl Hepatol. 2018;6(1):40-47.

Comprehensive Molecular Approach for Characterization of Hepatitis E Virus Genotype 3 Variants
Wang B, Harms D, Papp C, Niendorf S, Jacobsen S, Lütgehetmann M, Pischke S, Wedermeyer H, Hofmann J, Bock C
J CLIN MICROBIOL. 2018;56(5):e01686-17.

HEV-positive blood donations represent a relevant infection risk for immunosuppressed recipients
Westhölter D, Hiller J, Denzer U, Polywka S, Ayuk F, Rybczynski M, Horvatits T, Gundlach S, Blöcker J, Schulze Zur Wiesch J, Fischer N, Addo M, Peine S, Göke B, Lohse A, Lütgehetmann M, Pischke S
J HEPATOL. 2018;69(1):36-42.

Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection
Winer B, Shirvani-Dastgerdi E, Bram Y, Sellau J, Low B, Johnson H, Huang T, Hrebikova G, Heller B, Sharon Y, Giersch K, Gerges S, Seneca K, Pais M, Frankel A, Chiriboga L, Cullen J, Nahass R, Lutgehetmann M, Toettcher J, Wiles M, Schwartz R, Ploss A
SCI TRANSL MED. 2018;10(447):eaap9328.

Immunofluorescent Staining for the Detection of the Hepatitis B Core Antigen in Frozen Liver Sections of Human Liver Chimeric Mice
Allweiss L, Lütgehetmann M, Dandri M
Methods Mol Biol. 2017;1540:135-142.

Two-tier approach combining molecular and culture-based techniques for optimized detection of vancomycin-resistant enterococci
Both A, Franke G, Mirwald N, Lütgehetmann M, Christner M, Klupp E, Belmar Campos C, Büttner H, Aepfelbacher M, Rohde H
DIAGN MICR INFEC DIS. 2017;89(4):253-257.

Dose-dependent T-cell Dynamics and Cytokine Cascade Following rVSV-ZEBOV Immunization
Dahlke C, Kasonta R, Lunemann S, Krähling V, Zinser M, Biedenkopf N, Fehling S, Ly M, Rechtien A, Stubbe H, Olearo F, Borregaard S, Jambrecina A, Stahl F, Strecker T, Eickmann M, Lütgehetmann M, Spohn M, Schmiedel S, Lohse A, Becker S, Addo M
EBIOMEDICINE. 2017;19:107-118.

Serum HBV pgRNA as a clinical marker for cccDNA activity
Giersch K, Allweiss L, Volz T, Dandri-Petersen M, Lütgehetmann M
J HEPATOL. 2017;66(2):460-462.

Both interferon alpha and lambda can reduce all intrahepatic HDV infection markers in HBV/HDV infected humanized mice
Giersch K, Homs M, Volz T, Helbig M, Allweiss L, Lohse A, Petersen J, Buti M, Pollicino T, Sureau C, Dandri M, Lütgehetmann M
SCI REP-UK. 2017;7(1):3757.

Comparison of one commercial and two in-house TaqMan multiplex real-time PCR assays for detection of enteropathogenic, enterotoxigenic and enteroaggregative Escherichia coli
Hahn A, Lütgehetmann M, Landt O, Schwarz N, Frickmann H
TROP MED INT HEALTH. 2017;22(11):1371-1376.

Lymphocytes transiently expressing virus-specific T cell receptors reduce hepatitis B virus infection
Kah J, Koh S, Volz T, Ceccarello E, Allweiss L, Lütgehetmann M, Bertoletti A, Dandri M
J CLIN INVEST. 2017;127(8):3177-3188.

Heme oxygenase-1 polymorphisms can affect HCV replication and treatment responses with different efficacy in humanized mice
Kah J, Volz T, Lütgehetmann M, Groth A, Lohse A, Tiegs G, Sass G, Dandri-Petersen M
LIVER INT. 2017;37(8):1128-1137.

Multi-color RGB marking enables clonality assessment of liver tumors in a murine xenograft model
Thomaschewski M, Riecken K, Unrau L, Volz T, Cornils K, Ittrich H, Heim D, Wege H, Akgün E, Lütgehetmann M, Dieckhoff J, Köpke M, Dandri M, Benten D, Fehse B
ONCOTARGET. 2017;8(70):115582-115595.

Human liver chimeric mice as a new model of chronic hepatitis E virus infection and preclinical drug evaluation
Allweiss L, Gass S, Giersch K, Groth A, Kah J, Volz T, Rapp G, Schöbel A, Lohse A, Polywka S, Pischke S, Herker E, Dandri-Petersen M, Lütgehetmann M
J HEPATOL. 2016;64(5):1033-1040.

Primary Human Hepatocytes Repopulate Livers of Mice After In Vitro Culturing and Lentiviral-Mediated Gene Transfer
Bierwolf J, Volz T, Lütgehetmann M, Allweiss L, Riecken K, Warlich M, Fehse B, Kalff J, Dandri-Petersen M, Pollok J
TISSUE ENG. 2016;22(9-10):742-53.

Efficacy and safety of sofosbuvir/ledipasvir for the treatment of patients with hepatitis C virus re-infection after liver transplantation
Ciesek S, Proske V, Otto B, Pischke S, Costa R, Lütgehetmann M, Polywka S, Klempnauer J, Nashan B, Manns M, von Hahn T, Lohse A, Wedemeyer H, Mix H, Sterneck M
TRANSPL INFECT DIS. 2016;18(3):326-32.

Attenuated viral hepatitis in Trem1-/- mice is associated with reduced inflammatory activity of neutrophils
Kozik J, Trautmann T, Carambia A, Preti M, Lütgehetmann M, Krech T, Wiegard C, Heeren J, Herkel J
SCI REP-UK. 2016;6:28556.

Kinetics of HIV-1 latency reversal quantified on the single cell level using a novel flow-based technique
Martrus G, Niehrs A, Cornelis R, Rechtien A, García-Beltran W, Lütgehetmann M, Hoffmann C, Altfeld M
J VIROL. 2016;90(20):9018-9028.

Variability in long-term hepatitis B virus dynamics under antiviral therapy
Murray J, Stancevic O, Lütgehetmann M, Wursthorn K, Petersen J, Dandri-Petersen M
J THEOR BIOL. 2016;391:74-80.

Blood-borne Hepatitis E Virus Transmission: A Relevant Risk for Immunosuppressed Patients
Pischke S, Hiller J, Lütgehetmann M, Polywka S, Rybczynski M, Ayuketang F, Lohse A
CLIN INFECT DIS. 2016;63(4):569-570.

Changes in HIV-1 Capsid Stability Induced by Common Cytotoxic-T-Lymphocyte-Driven Viral Sequence Mutations
Schommers P, Martrus G, Matschl U, Sirignano M, Lütgehetmann M, Richert L, Hope T, Fätkenheuer G, Altfeld M
J VIROL. 2016;90(16):7579-86.

Experimental Models: Cell Culture and Animal Models
Dandri-Petersen M, Volz T, Lütgehetmann M
2015. Hepatitis B Virus in Human Diseases . Liaw Y, Zoulim F (Hrsg.). 1. Aufl. Springer International Publishing, 35-62.

Evaluation of Unbiased Next-Generation Sequencing of RNA (RNA-seq) as a Diagnostic Method in Influenza Virus-Positive Respiratory Samples
Fischer N, Indenbirken D, Meyer T, Lütgehetmann M, Lellek H, Spohn M, Aepfelbacher M, Alawi M, Grundhoff A
J CLIN MICROBIOL. 2015;53(7):2238-50.

Relevance of chronic hepatitis E in liver transplant recipients: a real-life setting
Galante A, Pischke S, Polywka S, Lütgehetmann M, Suneetha P, Gisa A, Hiller J, Dienes H, Nashan B, Lohse A, Sterneck M
TRANSPL INFECT DIS. 2015;17(4):617-22.

Hepatitis Delta co-infection in humanized mice leads to pronounced induction of innate immune responses in comparison to HBV mono-infection
Giersch K, Allweiss L, Volz T, Helbig M, Bierwolf J, Lohse A, Pollok J, Petersen J, Dandri-Petersen M, Lütgehetmann M
J HEPATOL. 2015;63(2):346-53.

Comparison of autochthonous and imported cases of hepatitis A or hepatitis E
Hartl J, Kreuels B, Polywka S, Addo M, Lütgehetmann M, Dandri-Petersen M, Dammermann W, Sterneck M, Lohse A, Pischke S
Z GASTROENTEROL. 2015;53(7):639-643.

Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody
Mailly L, Xiao F, Lupberger J, Wilson G, Aubert P, Duong F, Calabrese D, Leboeuf C, Fofana I, Thumann C, Bandiera S, Lütgehetmann M, Volz T, Davis C, Harris H, Mee C, Girardi E, Chane-Woon-Ming B, Ericsson M, Fletcher N, Bartenschlager R, Pessaux P, Vercauteren K, Meuleman P, Villa P, Kaderali L, Pfeffer S, Heim M, Neunlist M, Zeisel M, Dandri-Petersen M, McKeating J, Robinet E, Baumert T
NAT BIOTECHNOL. 2015;33(5):549-54.

Association of hepatitis E virus and essential cryoglobulinemia?
Pischke S, Polywka S, Haag F, Iking-Konert C, Sterneck M, Lütgehetmann M, Dammermann W, Lüth S, Schirmer J
J CLIN VIROL. 2015;67:23-24.

Immune cell responses are not required to induce substantial hepatitis B virus antigen decline during pegylated interferon-alpha administration
Allweiss L, Volz T, Lütgehetmann M, Giersch K, Bornscheuer T, Lohse A, Petersen J, Ma H, Klumpp K, Fletcher S, Dandri M
J HEPATOL. 2014;60(3):500-7.

Mouse models of hepatitis B and delta virus infection
Dandri M, Lütgehetmann M
J IMMUNOL METHODS. 2014;410:39-49.

Rapid Metagenomic Diagnostics for Suspected Outbreak of Severe Pneumonia
Fischer N, Rohde H, Indenbirken D, Günther T, Reumann K, Lütgehetmann M, Meyer T, Kluge S, Aepfelbacher M, Alawi M, Grundhoff A
EMERG INFECT DIS. 2014;20(6):1072-5.

Persistent hepatitis D virus mono-infection in humanized mice is efficiently converted by hepatitis B virus to a productive co-infection
Giersch K, Helbig M, Volz T, Allweiss L, Mancke L, Lohse A, Polywka S, Pollok J, Petersen J, Taylor J, Dandri M, Lütgehetmann M
J HEPATOL. 2014;60(3):538-44.

Relevance of a Full-Length Genomic RNA Standard and a Thermal-Shock Step for Optimal Hepatitis Delta Virus Quantification
Homs M, Giersch K, Blasi M, Lütgehetmann M, Buti M, Esteban R, Dandri M, Rodriguez-Frias F
J CLIN MICROBIOL. 2014;52(9):3334-8.

Improved Detection of Bacterial Central Nervous System Infections by Use of a Broad-Range PCR Assay
Meyer T, Franke G, Polywka S, Lütgehetmann M, Gbadamosi J, Magnus T, Aepfelbacher M
J CLIN MICROBIOL. 2014;52(5):1751-3.

Binding of hepatitis B virus to its cellular receptor alters the expression profile of genes of bile acid metabolism
Oehler N, Volz T, Bhadra O, Kah J, Allweiss L, Giersch K, Bierwolf J, Riecken K, Pollok J, Lohse A, Fehse B, Petersen J, Urban S, Lütgehetmann M, Heeren J, Dandri M
HEPATOLOGY. 2014.

New foe treated with old guns - supportive role of steroids in the treatment of acute severe hepatitis E
Sebode M, Pischke S, Lütgehetmann M, Polywka S, Quaas A, Lohse A, Wege H
BMC GASTROENTEROL. 2014;14(191):.

Experimental models and therapeutic approaches for HBV
Dandri M, Lütgehetmann M, Petersen J
SEMIN IMMUNOPATHOL. 2013;35(1):7-21.

Herpes simplex virus-1 encephalitis can trigger anti-NMDA receptor encephalitis: case report
Leypoldt F, Titulaer M, Aguilar E, Walther J, Bönstrup M, Havemeister S, Teegen B, Lütgehetmann M, Rosenkranz M, Magnus T, Dalmau J
NEUROLOGY. 2013;81(18):1637-9.

The entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized mice previously infected with hepatitis B virus
Volz T, Allweiss L, Ben MBarek M, Warlich M, Lohse A, Pollok J, Alexandrov A, Urban S, Petersen J, Lütgehetmann M, Dandri M
J HEPATOL. 2013;58(5):861-7.

Primary human hepatocytes from metabolic-disordered children recreate highly differentiated liver-tissue-like spheroids on alginate scaffolds.
Bierwolf J, Lütgehetmann M, Deichmann S, Erbes J, Volz T, Dandri-Petersen M, Cohen S, Nashan B, Pollok J
TISSUE ENG. 2012;18(13-14):1443-1453.

Humanized chimeric uPA mouse model for the study of hepatitis B and D virus interactions and preclinical drug evaluation.
Lütgehetmann M, Mancke L, Volz T, Helbig M, Allweiss L, Bornscheuer T, Pollok J, Lohse A, Petersen J, Urban S, Dandri-Petersen M
HEPATOLOGY. 2012;55(3):685-694.

Entecavir plus tenofovir combination as rescue therapy in pre-treated chronic hepatitis B patients: an international multicenter cohort study.
Petersen J, Ratziu V, Buti M, Janssen H, Brown A, Lampertico P, Schollmeyer J, Zoulim F, Wedemeyer H, Sterneck M, Berg T, Sarrazin C, Lütgehetmann M, Buggisch P
J HEPATOL. 2012;56(3):520-526.

Strong antiviral activity of the new l-hydroxycytidine derivative, l-Hyd4FC, in HBV-infected human chimeric uPA/SCID mice.
Volz T, Lütgehetmann M, Allweiss L, Warlich M, Bierwolf J, Pollok J, Petersen J, Matthes E, Dandri-Petersen M
ANTIVIR THER. 2012;17(4):623-631.

Primary rat hepatocyte culture on 3D nanofibrous polymer scaffolds for toxicology and pharmaceutical research.
Bierwolf J, Lütgehetmann M, Feng K, Erbes J, Deichmann S, Toronyi E, Stieglitz C, Nashan B, Ma P, Pollok J
BIOTECHNOL BIOENG. 2011;108(1):141-150.

Hepatitis B virus limits response of human hepatocytes to interferon-α in chimeric mice.
Lütgehetmann M, Bornscheuer T, Volz T, Allweiss L, Bockmann J, Pollok J, Lohse A, Petersen J, Dandri-Petersen M
GASTROENTEROLOGY. 2011;140(7):1-2, 2074-2083.

Desperately seeking diarrhoea: outbreak of haemolytic uraemic syndrome caused by emerging sorbitol-fermenting shiga toxin-producing Escherichia coli O157:H-, Germany, 2009.
Nielsen S, Frank C, Fruth A, Spode A, Prager R, Graff A, Plenge-Bönig A, Loos S, Lütgehetmann M, Kemper M, Müller-Wiefel D, Werber D
ZOONOSES PUBLIC HLTH. 2011;58(8):567-572.

RGB marking facilitates multicolor clonal cell tracking.
Riecken K, Thomaschewski M, Warlich M, Volz T, Cornils K, Niebuhr B, Täger M, Lütgehetmann M, Pollok J, Stocking C, Dandri-Petersen M, Benten D, Fehse B
NAT MED. 2011;17(4):504-509.

Primary human hepatocytes on biodegradable poly(l-lactic acid) matrices: a promising model for improving transplantation efficiency with tissue engineering.
Török-Pollok E, Lütgehetmann M, Bierwolf J, Melbeck S, Düllmann J, Nashan B, Ma P, Pollok J
LIVER TRANSPLANT. 2011;17(2):104-114.

Forced activation of β-catenin signaling supports the transformation of hTERT-immortalized human fetal hepatocytes.
Wege H, Heim D, Lütgehetmann M, Dierlamm J, Lohse A, Brümmendorf T
MOL CANCER RES. 2011;9(9):1222-1231.

Entecavir treatment for chronic hepatitis B: adaptation is not needed for the majority of naïve patients with a partial virological response
Zoutendijk R, Reijnders J, Brown A, Zoulim F, Mutimer D, Deterding K, Petersen J, Hofmann W, Buti M, Santantonio T, van Bömmel F, Pradat P, Oo Y, Lütgehetmann M, Berg T, Hansen B, Wedemeyer H, Janssen H
HEPATOLOGY. 2011;54(2):443-51.

Wissensstand, Präventionsverhalten und Therapieadhärenz von Patienten mit chronischer Hepatitis B in einem großen tertiären Zentrum in Deutschland
Lutgehetmann M, Meyer F, Volz T, Lohse A, Fischer C, Dandri M, Petersen J
Z GASTROENTEROL. 2010;48(9):1126-32.

[Knowledge about HBV, prevention behaviour and treatment adherence of patients with chronic hepatitis B in a large referral centre in Germany].
Lütgehetmann M, Meyer F, Volz T, Lohse A, Fischer C, Dandri-Petersen M, Petersen J
Z GASTROENTEROL. 2010;48(9):1126-1132.

In vivo proliferation of hepadnavirus-infected hepatocytes induces loss of covalently closed circular DNA in mice.
Lütgehetmann M, Volz T, Köpke A, Broja T, Tigges E, Lohse A, Fuchs E, Murray J, Petersen J, Dandri-Petersen M
HEPATOLOGY. 2010;52(1):16-24.

Virion half-life in chronic hepatitis B infection is strongly correlated with levels of viremia.
Dandri-Petersen M, Murray J, Lütgehetmann M, Volz T, Lohse A, Petersen J
HEPATOLOGY. 2008;48(4):1079-1086.

Sequential combination therapy leads to biochemical and histological improvement despite low ongoing intrahepatic hepatitis B virus replication.
Lütgehetmann M, Volz T, Quaas A, Zankel M, Fischer C, Dandri-Petersen M, Petersen J
ANTIVIR THER. 2008;13(1):57-66.

Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein.
Petersen J, Dandri-Petersen M, Mier W, Lütgehetmann M, Volz T, von Weizsäcker F, Haberkorn U, Fischer L, Pollok J, Erbes B, Seitz S, Urban S
NAT BIOTECHNOL. 2008;26(3):335-341.

Impaired intrahepatic hepatitis B virus productivity contributes to low viremia in most HBeAg-negative patients.
Volz T, Lütgehetmann M, Wachtler P, Jacob A, Quaas A, Murray J, Dandri-Petersen M, Petersen J
GASTROENTEROLOGY. 2007;133(3):843-852.

Small animal model systems for studying hepatitis B virus replication and pathogenesis.
Dandri-Petersen M, Lütgehetmann M, Volz T, Petersen J
SEMIN LIVER DIS. 2006;26(2):181-191.

Morphological and functional analysis of rat hepatocyte spheroids generated on poly(L-lactic acid) polymer in a pulsatile flow bioreactor.
Török E, Vogel C, Lütgehetmann M, Ma P, Dandri-Petersen M, Petersen J, Burda M, Siebert K, Düllmann J, Rogiers X, Pollok J
TISSUE ENG. 2006;12(7):1881-1890.

Temporary HBV resolution in an HIV-coinfected patient during HBV-directed combination therapy followed by relapse of HBV.
Wursthorn K, Buggisch P, Lütgehetmann M, Zollner B, Petersen J
ANTIVIR THER. 2006;11(5):647-652.

Peginterferon alpha-2b plus adefovir induce strong cccDNA decline and HBsAg reduction in patients with chronic hepatitis B.
Wursthorn K, Lütgehetmann M, Dandri-Petersen M, Volz T, Buggisch P, Zollner B, Longerich T, Schirmacher P, Metzler F, Zankel M, Fischer C, Currie G, Brosgart C, Petersen J
HEPATOLOGY. 2006;44(3):675-684.

Animal models for the study of HBV replication and its variants.
Dandri-Petersen M, Volz T, Lütgehetmann M, Petersen J
J CLIN VIROL. 2005;34(1):54-62.

The liver stage of Plasmodium berghei inhibits host cell apoptosis.
van de Sand C, Horstmann S, Schmidt A, Sturm A, Bolte S, Krueger A, Lütgehetmann M, Pollok J, Libert C, Heussler V
MOL MICROBIOL. 2005;58(3):731-742.

Letzte Aktualisierung aus dem FIS: 04.12.2022 - 00:37 Uhr