- Bioinformatik Facility
Tätigkeitsschwerpunkte
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Developing analysis pipeline for whole genome sequencing data (raw data QC, mapping, marking duplicate, coverage etc.)
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Developing mutation calling and annotation pipeline
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Analyzing next-generation sequencing data using popular NGS analysis tools like BWA, GATK, Samtools, Picard-tools, Bedtools, Bowtie2 etc.
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Analyzing next-generation sequencing data using the publicly available biological databases and servers like NCBI, PDB, dbSNP, KEGG, RefSeq, EntrezGene, GeneBank, Ensembl, Pfam, GO etc.
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Development of bioinformatics tools for RNA secondary structure analysis etc.
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High performance and parallelization computing (SGE, PBS etc.)
Lebenslauf
Publikationen
Distinct clonal lineages and within-host diversification shape invasive Staphylococcus epidermidis populations
Both A, Huang J, Qi M, Lausmann C, Weißelberg S, Büttner H, Lezius S, Failla A, Christner M, Stegger M, Gehrke T, Baig S, Citak M, Alawi M, Aepfelbacher M, Rohde H
PLOS PATHOG. 2021;17(2):e1009304.
Strong Replication Interference Between Hepatitis Delta Viruses in Human Liver Chimeric Mice
Giersch K, Hermanussen L, Volz T, Volmari A, Allweiss L, Sureau C, Casey J, Huang J, Fischer N, Lütgehetmann M, Dandri M
FRONT MICROBIOL. 2021;12:671466.
Simulation of Folding Kinetics for Aligned RNAs
Huang J, Voß B
GENES-BASEL. 2021;12(3):.
An inter‑laboratory study to investigate the impact of the bioinformatics component on microbiome analysis using mock communities
O’Sullivan D, Doyle R, Temisak S, Redshaw N, Whale A, Logan G, Huang J, Fischer N, Amos G, Preston M, Marchesi J, Wagner J, Parkhill J, Motro Y, Denise H, Finn R, Kay G, O'Grady J, Ransom-Jones E, Wu H, Laing E, Benavente E, Phelan J, Clark T, Moran-Gilad J, Huggett J
SCI REP-UK. 2021;11(1):10590.
SARS Coronavirus-2 variant tracing within the first Coronavirus Disease 19 clusters in northern Germany
Pfefferle S, Günther T, Kobbe R, Czech-Sioli M, Nörz D, Santer R, Oh J, Kluge S, Oestereich L, Peldschus K, Indenbirken D, Huang J, Grundhoff A, Aepfelbacher M, Knobloch J, Lütgehetmann M, Fischer N
CLIN MICROBIOL INFEC. 2021;27(1):130.e5-130.e8.
Vertically transferred maternal immune cells promote neonatal immunity against early life infections
Stelzer I, Urbschat C, Schepanski S, Thiele K, Triviai I, Wieczorek A, Alawi M, Ohnezeit D, Kottlau J, Huang J, Fischer N, Mittrücker H, Solano M, Fehse B, Diemert A, Stahl F, Arck P
NAT COMMUN. 2021;12(1):4706.
Benchmark of thirteen bioinformatic pipelines for metagenomic virus diagnostics using datasets from clinical samples
Vries J, Brown J, Fischer N, Sidorov I, Morfopoulou S, Huang J, Claas E
J CLIN VIROL. 2021;141(104908):.
Complete Genome Sequence of a SARS-CoV-2 Strain Isolated in Northern Germany
Pfefferle S, Huang J, Nörz D, Indenbirken D, Lütgehetmann M, Oestereich L, Günther T, Grundhoff A, Aepfelbacher M, Fischer N
Microbiol Resour Announc. 2020;9(23):.
T-lymphocyte-specific knockout of IKK-2 or NEMO induces T17 cells in an experimental nephrotoxic nephritis mouse model
Guo L, Huang J, Chen M, Piotrowski E, Song N, Zahner G, Paust H, Alawi M, Geffers R, Thaiss F
FASEB J. 2019;33(2):2359-2371.
Changes in the composition of the upper respiratory tract microbial community in granulomatosis with polyangiitis
Lamprecht P, Fischer N, Huang J, Burkhardt L, Lütgehetmann M, Arndt F, Rolfs I, Kerstein A, Iking-Konert C, Laudien M
J AUTOIMMUN. 2019;97:29-39.
Emergence of ceftazidime/avibactam non-susceptibility in an MDR Klebsiella pneumoniae isolate
Both A, Büttner H, Huang J, Perbandt M, Belmar Campos C, Christner M, Maurer F, Kluge S, König C, Aepfelbacher M, Wichmann D, Rohde H
J ANTIMICROB CHEMOTH. 2017;72(9):2483-2488.
First report of Escherichia coli co-producing NDM-1 and OXA-232
Both A, Huang J, Kaase M, Hezel J, Wertheimer D, Fenner I, Günther T, Grundhoff A, Büttner H, Aepfelbacher M, Rohde H, Hentschke M
DIAGN MICR INFEC DIS. 2016;86(4):437-438.
Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney
Krebs C, Paust H, Krohn S, Koyro T, Brix S, Riedel J, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch C, Mittrücker H, Steinhoff U, Stockinger B, Perez L, Wenzel U, Janneck M, Steinmetz O, Gagliani N, Stahl R, Huber S, Turner J, Panzer U
IMMUNITY. 2016;45(5):1078-1092.
Analysing RNA-kinetics based on folding space abstraction
Huang J, Voß B
BMC BIOINFORMATICS. 2014;15(1):60.
Abstract folding space analysis based on helices
Huang J, Backofen R, Voß B
RNA. 2012;18(12):2135-2147.
Reducing the search space in RNA helix based folding. European Conference on Computational Biology
Huang J, Voß B
2012. European Conference on Computational Biology (ECCB) 2012. .
RNAHeliCes -- Folding space analysis based on position aware structure abstraction
Huang J, Voß B
2011. In Proceedings of the German Conference on Bioinformatics 2011. RT--31.
Letzte Aktualisierung aus dem FIS: 27.09.2021 - 00:36 Uhr