Aktuelle Publikationen:

2021Bunduc CM, Fahrenkamp D, Wald J, Ummels R, Bitter W, Houben ENG, Marlovits TC (2021) Structure and dynamics of a mycobacterial type VII secretion system Nature. doi: 10.1038/s41586-021-03517-z.
 Miletic S, Fahrenkamp D, Goessweiner-Mohr N, Wald J, Pantel M, Vesper O, Kotov V, Marlovits TC. Substrate-engaged type III secretion system structures reveal gating mechanism for unfolded protein translocation. Nat Commun. 2021 Mar 9;12(1):1546. doi: 10.1038/s41467-021-21143-1. PMID: 33750771; PMCID: PMC7943601.
 Kotov V, Mlynek G, Vesper O, Pletzer M, Wald J, Teixeira-Duarte CM, Celia H, Garcia-Alai M, Nussberger S, Buchanan SK, Morais-Cabral JH, Loew C, Djinovic-Carugo K, Marlovits TC (2021) In-depth interrogation of protein thermal unfolding data with MoltenProt. Protein Sci. 30(1):201-217. doi: 10.1002/pro.3986. PMID: 33140490
2020Pinotsis N, Zielinska K, Babuta M, Arolas JL, Kostan J, Khan MB, Schreiner C, Salmazo A, Ciccarelli L, Puchinger M, Gkougkoulia EA, Ribeiro EA Jr, Marlovits TC, Bhattacharya A, Djinovic-Carugo K (2020) Calcium modulates the domain flexibility and function of an α-actinin similar to the ancestral α-actinin. Proc Natl Acad Sci U S A. 117(36):22101-22112. doi: 10.1073/pnas.1917269117.
 Miletic S, Goessweiner-Mohr N, Marlovits TC (2020) The Structure of the Type III Secretion System Needle Complex. Curr Top Microbiol Immunol. 427:67-90. doi: 10.1007/82_2019_178.
 Chabloz A, Schaefer J V, Kozieradzki I, Cronin S J F, Strebinger D, Macaluso F, Wald J, Rabbitts T H, Plückthun A, Marlovits TC, Penninger J M (2020). Salmonella-based platform for efficient delivery of functional binding proteins to the cytosol. Commun Biol 3, 342. doi.org/10.1038/s42003-020-1072-4
2019Kotov V, Vesper O, Alai M G, Loew C, Marlovits TC (2019) Moltenprot: A High-Throughput Analysis Platform to Assess Thermodynamic Stability of Membrane Proteins and Complexes. Biophysical Journal 116 (3), 191a. https://doi.org/10.1016/j.bpj.2018.11.1060
 Miletic S, Goessweiner-Mohr N, Marlovits TC (2019) The Structure of the Type III Secretion System Needle Complex. Current Topics in Microbiology and Immunology. Springer, Berlin, Heidelberg. doi.org/10.1007/82_2019_178
 Wald J, Pasin M, Richter M, Walther CH, Mathai N, Kirchmair J, Makarov VA, Gössweiner-Mohr N, Marlovits TC, Zanella I, Real-Hohn A, Verdaguer N, Blaas D, Schmidtke M. Cryo-EM Structure of Pleconaril-Resistant Rhinovirus-B5 Complexed to the Antiviral OBR-5-340 Reveals Unexpected Binding Site. PNAS 2019 Sept 17;116(38):19109–19115. doi: 10.1073/pnas.1904732116
 Kotov V, Bartels K, Veith K, Josts I, Subhramanyam UKT, Günther C, Labahn J, Marlovits TC, Moraes I, Tidow H, Löw C, Garcia-Alai MM (2019) High-throughput stability screening for detergent-solubilized membrane proteins. Sci Rep. 2019 Jul 17;9(1):10379. doi: 10.1038/s41598-019-46686-8.
 Guo EZ, Desrosiers DC, Zalesak J, Tolchard J, Berbon M, Habenstein B, Marlovits T, Loquet A, Galán JE (2019) A polymorphic helix of a Salmonella needle protein relays signals defining distinct steps in type III secretion. PLoS Biol. 2019 Jul 1;17(7):e3000351. doi: 10.1371/journal.pbio.3000351
2017Beckham KSH, Ciccarelli L., Bunduc CM, Mertens HDT, Ummels R, Lugmayr L, Mayr J, Rettel M, Savitski MM, Svergun DI, Bitter W, Wilmanns M, Marlovits TC*, Parret AHA*, Houben ENG* (2017). Structure of the mycobacterial ESX-5 type VII secretion system membrane complex by single-particle analysis. Nature Microbiology 10;2:17047. doi: 10.1038/nmicrobiol.2017.47
 Song M , Sukovich DJ, Ciccarelli L, Mayr J, Fernandez-Rodriguez J, Mirsky EA, Tucker AC, Gordon DB, Marlovits TC, Voigt CA (2017) Control of type III protein secretion using a minimal genetic system. Nature communications 9;8:14737. doi: 10.1038/ncomms14737.
2016 Dietsche, T., Tesfazgi Mebrhatu, M., Brunner, MJ., Abrusci, P., Yan, J., Franz-Wachtel, M., Schärfe, C., Zilkenat, S., Grin, I., Galán, JE., Kohlbacher, O., Lea, S., Macek, B., Marlovits, TC., Robinson, CV., Wagner, S. (2016). Structural and Functional Characterization of the Bacterial Type III Secretion Export Apparatus. PLoS Pathog.12(12): e1006071
 Smaldone, G., Pirone, L., Pedone, E., Marlovits, T., Vitagliano, L., Ciccarelli, L. (2016). The BTB domains of the potassium channel tetramerization domain proteins prevalently assume petameric states. FEBS Lett. 590(11): 1663-71
2015DiMaio, F., Song, Y., Li, X., Brunner, MJ., Xu, C., Conticello, V., Egelman, E., Marlovits, TC., Cheng, Y., Baker, D. (2015). Atomic-accuracy models from 4.5-Å cryo-electron microscopy data with density-guided iterative local refinement. Nat Methods. 12(4):361-5
2014Galán, JE., Lara-Tejero, M., Marlovits, TC., Wagner, S. (2014). Bacterial type III secretion systems: specialized nanomachines for protein delivery into target cells. Annu Rev Microbiol. 68:415-38
 Hornung, P., Troc, P., Malvezzi, F., Maier, M., Demianova, Z., Zimniak, T., Litos, G., Lampert, F., Schleiffer, A., Brunner, M., Mechtler, K., Herzog, F., Marlovits, TC., Westermann, S. (2014). A cooperative mechanism drives budding yeast kinetochore assembly downstream of CENP-A. J Cell Biol. 206(4):509-24
 Radics, J., Königsmaier, L., Marlovits, TC. (2014). Structure of a pathogenic type 3 secretion system in action. Nat Struct Mol Biol.21(1):82-7
2013Simunovic, M., Mim, C., Marlovits, TC., Resch, G., Unger, VM., Voth, GA. (2013). Protein-mediated transformation of lipid vesicles into tubular networks. Biophys J. 105(3):711-9
2012Fernandez-Rodriguez, J., Marlovits, TC. (2012). Induced heterodimerization and purification of two target proteins by a synthetic coiled-coil tag. Protein Sci. 21(4):511-9
 Kosarewicz, A., Königsmaier, L., Marlovits, TC. (2012). The blueprint of the type-3 injectisome. Philos Trans R Soc Lond B Biol Sci.367(1592):1140-54