Edzard Schwedhelm
Prof. Dr. rer. nat.
Edzard Schwedhelm
  • Forschungsgruppenleiter
  • Fachpharmakologe DGPT
Arbeitsbereich

Standort

N30 Fritz Schumacher-Haus, 1. Etage, Raumnummer 111a
Sprachen
Deutsch (Muttersprache)
Englisch

Tätigkeitsschwerpunkte

Lebenslauf

Publikationen

2021

Association of lipid levels with motor and cognitive function and decline in advanced Parkinson's disease in the Mark-PD study
Choe C, Petersen E, Lezius S, Cheng B, Schulz R, Buhmann C, Pötter-Nerger M, Daum G, Blankenberg S, Gerloff C, Schwedhelm E, Zeller T
PARKINSONISM RELAT D. 2021;85:5-10.

Reply to: "Parkin Deficiency Appears Not to Be Associated with Cardiac Damage in Parkinson's Disease"
Choe C, Pötter-Nerger M, Buhmann C, Blankenberg S, Gerloff C, Schwedhelm E, Zeller T
MOVEMENT DISORD. 2021;36(1):273-274.

Reference ranges for sphingosine-1-phosphate in neonates
Ebenebe C, von Lucadou M, Moritz E, Schwedhelm E, Daum G, Singer D, Deindl P, Winkler M
J PERINAT MED. 2021;49(7):932-935.

Elevated serum SDMA and ADMA at hospital admission predict in-hospital mortality of COVID-19 patients
Hannemann J, Balfanz P, Schwedhelm E, Hartmann B, Ule J, Müller-Wieland D, Dahl E, Dreher M, Marx N, Böger R
SCI REP-UK. 2021;11(1):.

Arginine:Glycine Amidinotransferase Is Essential for Creatine Supply in Mice During Chronic Hypoxia
Hannemann J, Cordts K, Seniuk A, Choe C, Schmidt-Hutten L, Duque Escobar J, Weinberger F, Böger R, Schwedhelm E
FRONT PHYSIOL. 2021;12:703069.

Anti-inflammatory HDL effects are impaired in atrial fibrillation
Holzwirth E, Fischer-Schaepmann T, Obradovic D, von Lucadou M, Schwedhelm E, Daum G, Hindricks G, Marsche G, Trieb M, Thiele H, Kornej J, Büttner P
HEART VESSELS. 2021 [Epub ahead of print].

Intrathecal and systemic alterations of L-arginine metabolism in patients after intracerebral hemorrhage
Mader M, Böger R, Appel D, Schwedhelm E, Haddad M, Mohme M, Lamszus K, Westphal M, Czorlich P, Hannemann J
J CEREBR BLOOD F MET. 2021;41(8):1964-1977.

Homoarginine and blood pressure: a 10-year prospective relationship in normotensives
Mokhaneli M, Botha-Le Roux S, Fourie C, Böger R, Schwedhelm E, Mels C
J HUM HYPERTENS. 2021 [Epub ahead of print].

L-homoarginine is associated with decreased cardiovascular- and all-cause mortality
Mokhaneli M, Botha-Le Roux S, Fourie C, Böger R, Schwedhelm E, Mels C
EUR J CLIN INVEST. 2021;51(5):.

Increased Sphingosine-1-Phosphate Serum Concentrations in Subjects with Periodontitis: A Matter of Inflammation
Moritz E, Jedlitschky G, Negnal J, Tzvetkov M, Daum G, Dörr M, Felix S, Völzke H, Nauck M, Schwedhelm E, Meisel P, Kocher T, Rauch B, Holtfreter B
J INFLAMM RES. 2021;14:2883-2896.

Trimethyllysine, vascular risk factors and outcome in acute ischemic stroke (MARK-STROKE)
Schwedhelm E, von Lucadou M, Peine S, Lezius S, Thomalla G, Böger R, Gerloff C, Choe C
AMINO ACIDS. 2021;53(4):555-561.

Blood pressure and nitric oxide synthesis capacity in physically active and inactive groups: the SABPA study
van Niekerk E, Botha Le Roux S, Atzler D, Schwedhelm E, Böger R, van Rooyen J, Moss S, Mels C
J HUM HYPERTENS. 2021;35(4):325-333.

Associations of circulating dimethylarginines with the metabolic syndrome in the Framingham Offspring study
Yola I, Moser C, Duncan M, Schwedhelm E, Atzler D, Maas R, Hannemann J, Böger R, Vasan R, Xanthakis V
PLOS ONE. 2021;16(9):e0254577.

2020

Arginine derivatives in atrial fibrillation progression phenotypes
Büttner P, Bahls M, Böger R, Hindricks G, Thiele H, Schwedhelm E, Kornej J
J MOL MED. 2020;98(7):999-1008.

Low homoarginine/SDMA ratio is associated with poor short- and long-term outcome after stroke in two prospective studies
Choe C, Lezius S, Cordts K, Gerloff C, Böger R, Schwedhelm E, Grant P
NEUROL SCI. 2020;41(1):149-153.

Subclinical Cardiac Microdamage, Motor Severity, and Cognition in Parkinson's Disease
Choe C, Niemann L, Englisch C, Petersen E, Buhmann C, Pötter-Nerger M, Blankenberg S, Gerloff C, Schwedhelm E, Zeller T
MOVEMENT DISORD. 2020;35(10):1863-1868.

Reply to: "N-Terminal Pro-B-Type Natriuretic Peptide Levels in Parkinson's Disease"
Choe C, Petersen E, Pötter-Nerger M, Buhmann C, Blankenberg S, Gerloff C, Schwedhelm E, Zeller T
MOVEMENT DISORD. 2020;35(10):1888.

Determinants of Serum- and Plasma Sphingosine-1-Phosphate Concentrations in a Healthy Study Group
Daum G, Winkler M, Moritz E, Müller T, Geffken M, von Lucadou M, Haddad M, Peine S, Böger R, Larena-Avellaneda A, Debus E, Gräler M, Schwedhelm E
TH Open. 2020;4(1):e12-e19.

Increased Serum Levels of Asymmetric Dimethylarginine and Symmetric Dimethylarginine and Decreased Levels of Arginine in Sudanese Patients with Essential Hypertension
Gamil S, Erdmann J, Schwedhelm E, Bakheit K, Abdalrahman I, Mohamed A
Kidney Blood Press Res. 2020;45(5):727-736.

Arginine Derivatives in Cerebrovascular Diseases: Mechanisms and Clinical Implications
Grosse G, Schwedhelm E, Worthmann H, Choe C
INT J MOL SCI. 2020;21(5):.

Analysis of L-arginine:glycine amidinotransferase-, creatine- and homoarginine-dependent gene regulation in the murine heart
Jensen M, Müller C, Choe C, Schwedhelm E, Zeller T
SCI REP-UK. 2020;10(1):.

Homoarginine- and Creatine-Dependent Gene Regulation in Murine Brains with l-Arginine:Glycine Amidinotransferase Deficiency
Jensen M, Müller C, Schwedhelm E, Arunachalam P, Gelderblom M, Magnus T, Gerloff C, Zeller T, Choe C
INT J MOL SCI. 2020;21(5):.

Asymmetric dimethylarginine and L-homoarginine prospectively relate to carotid wall thickness in a South African cohort
Mokhaneli M, Fourie C, Botha-Le Roux S, Böger R, Schwedhelm E, Mels C
AMINO ACIDS. 2020;52(6-7):965-973.

Creatine, guanidinoacetate and homoarginine in statin-induced myopathy
Neu A, Hornig S, Sasani A, Isbrandt D, Gerloff C, Tsikas D, Schwedhelm E, Choe C
AMINO ACIDS. 2020;52(6-7):1067-1069.

Personalised haemodynamic management targeting baseline cardiac index in high-risk patients undergoing major abdominal surgery: a randomised single-centre clinical trial
Nicklas J, Diener O, Leistenschneider M, Sellhorn C, Schön G, Winkler M, Daum G, Schwedhelm E, Schröder J, Fisch M, Schmalfeldt B, Izbicki J, Bauer M, Coldewey S, Reuter D, Saugel B
BRIT J ANAESTH. 2020;125(2):122-132.

Muscle phenotype of AGAT- and GAMT-deficient mice after simvastatin exposure
Sasani A, Hornig S, Grzybowski R, Cordts K, Hanff E, Tsikas D, Böger R, Gerloff C, Isbrandt D, Neu A, Schwedhelm E, Choe C
AMINO ACIDS. 2020;52(1):73-85.

Association of Lower Plasma Homoarginine Concentrations with Greater Risk of All-Cause Mortality in the Community: The Framingham Offspring Study
Schwedhelm E, Song R, Vasan R, van den Heuvel E, Hannemann J, Xanthakis V, Böger R
J CLIN MED. 2020;9(6):.

Circulating metabolites differentiate acute ischemic stroke from stroke mimics
Tiedt S, Brandmaier S, Kollmeier H, Duering M, Artati A, Adamski J, Klein M, Liebig T, Holdt L, Teupser D, Wang-Sattler R, Schwedhelm E, Gieger C, Dichgans M
ANN NEUROL. 2020;88(4):736-746.

2019

Evidence by GC-MS that lysine is an arginase-catalyzed metabolite of homoarginine in vitro and in vivo in humans
Bollenbach A, Cordts K, Hanff E, Atzler D, Choe C, Schwedhelm E, Tsikas D
ANAL BIOCHEM. 2019;577:59-66.

Guanidino compound ratios are associated with stroke etiology, internal carotid artery stenosis and CHA(2)DS(2)-VASc score in three cross-sectional studies
Cordts K, Grzybowski R, Lezius S, Lüneburg N, Atzler D, Neu A, Hornig S, Böger R, Gerloff C, Magnus T, Thomalla G, Schwedhelm E, Grant P, Choe C
J NEUROL SCI. 2019;397:156-161.

Association of Asymmetric Dimethylarginine and Diastolic Dysfunction in Patients with Hypertrophic Cardiomyopathy
Cordts K, Seelig D, Lund N, Carrier L, Böger R, Avanesov M, Tahir E, Schwedhelm E, Patten M
BIOMOLECULES. 2019;9(7):.

Myeloid-Derived Suppressor Cells Mediate Immunosuppression After Cardiopulmonary Bypass
Hübner M, Tomasi R, Effinger D, Wu T, Klein G, Bender M, Kilger E, Juchem G, Schwedhelm E, Kreth S
CRIT CARE MED. 2019;47(8):e700-e709.

Analyses of sphingosine-1-phosphate in the context of transfusion: how much is in stored blood products and in patient blood?
Poppe A, Moritz E, Geffken M, Schreiber J, Greiwe G, Amschler K, Wruck M, Schwedhelm E, Daum G, Kluge S, Peine S, Winkler M
TRANSFUSION. 2019;59(10):3071-3076.

Effect of ranolazine on plasma arginine derivatives and urinary isoprostane 8-iso-PGF2α in patients with myocardial infarction in the randomized RIMINI-Trial
Schwemer T, Deutscher N, Diermann N, Böger R, Schwedhelm E, Blankenberg S, Friedrich F
SCI REP-UK. 2019;9(1):5708.

Asymmetric Dimethylarginine at Sea Level Is a Predictive Marker of Hypoxic Pulmonary Arterial Hypertension at High Altitude
Siques P, Brito J, Schwedhelm E, Pena E, León-Velarde F, De La Cruz J, Böger R, Hannemann J
FRONT PHYSIOL. 2019;10:651.

Loss of sphingosine 1-phosphate (S1P) in septic shock is predominantly caused by decreased levels of high-density lipoproteins (HDL)
Winkler M, Märtz K, Nierhaus A, Daum G, Schwedhelm E, Kluge S, Gräler M
Journal of intensive care. 2019;7:23.

2018

Asymmetric and Symmetric Dimethylarginines are Markers of Delayed Cerebral Ischemia and Neurological Outcome in Patients with Subarachnoid Hemorrhage
Appel D, Seeberger M, Schwedhelm E, Czorlich P, Goetz A, Böger R, Hannemann J
NEUROCRIT CARE. 2018;29(1):84-93.

Low-Circulating Homoarginine is Associated with Dilatation and Decreased Function of the Left Ventricle in the General Population
Bahls M, Atzler D, Markus M, Friedrich N, Böger R, Völzke H, Felix S, Schwedhelm E, Dörr M
BIOMOLECULES. 2018;8(3):e63.

Relationship between exercise intervention and NO pathway in patients with heart failure with preserved ejection fraction
Baldassarri F, Schwedhelm E, Atzler D, Böger R, Cordts K, Haller B, Pressler A, Müller S, Suchy C, Wachter R, Düngen H, Hasenfuss G, Pieske B, Halle M, Edelmann F, Duvinage A
BIOMARKERS. 2018;23(6):540-550.

Oxidative stress in drug-naïve first episode patients with schizophrenia and major depression: effects of disease acuity and potential confounders
Jordan W, Dobrowolny H, Bahn S, Bernstein H, Brigadski T, Frodl T, Isermann B, Lessmann V, Pilz J, Rodenbeck A, Schiltz K, Schwedhelm E, Tumani H, Wiltfang J, Guest P, Steiner J
EUR ARCH PSY CLIN N. 2018;268(2):129-143.

Serum Biomarkers of Endothelial Dysfunction in Fabry Associated Cardiomyopathy
Loso J, Lund N, Avanesov M, Muschol N, Lezius S, Cordts K, Schwedhelm E, Patten M
FRONT CARDIOVASC MED. 2018;5:108.

Platelet activation parameters and platelet-leucocyte-conjugate formation in glioblastoma multiforme patients
Marx S, Splittstöhser M, Kinnen F, Moritz E, Joseph C, Paul S, Paland H, Seifert C, Marx M, Böhm A, Schwedhelm E, Holzer K, Singer S, Ritter C, Bien-Möller S, Schroeder H, Rauch B
ONCOTARGET. 2018;9(40):25860-25876.

Cross-Sectional Associations between Homoarginine, Intermediate Phenotypes, and Atrial Fibrillation in the Community-The Gutenberg Health Study
Niekamp C, Atzler D, Ojeda F, Sinning C, Lackner K, Böger R, Munzel T, Beutel M, Schmidtmann I, Pfeiffer N, Leuschner A, Blankenberg S, Wild P, Zeller T, Schwedhelm E, Schnabel R
BIOMOLECULES. 2018;8(3):E86.

Cognitive performance of 20 healthy humans supplemented with L-homoarginine for 4 weeks
Schönhoff M, Weineck G, Hoppe J, Hornig S, Cordts K, Atzler D, Gerloff C, Böger R, Neu A, Schwedhelm E, Choe C
J CLIN NEUROSCI. 2018;50:237-241.

Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone loss
Weske S, Vaidya M, Reese A, von Wnuck Lipinski K, Keul P, Bayer J, Fischer J, Flögel U, Nelsen J, Epple M, Scatena M, Schwedhelm E, Dörr M, Völzke H, Moritz E, Hannemann A, Rauch B, Gräler M, Heusch G, Levkau B
NAT MED. 2018;24(5):667-678.

Symmetrical (SDMA) and asymmetrical dimethylarginine (ADMA) in sepsis: high plasma levels as combined risk markers for sepsis survival
Winkler M, Nierhaus A, Rösler G, Lezius S, Harlandt O, Schwedhelm E, Böger R, Kluge S
CRIT CARE. 2018;22(1):216.

2017

Dietary Supplementation with Homoarginine Preserves Cardiac Function in a Murine Model of Post-Myocardial Infarction Heart Failure
Atzler D, McAndrew D, Cordts K, Schneider J, Zervou S, Schwedhelm E, Neubauer S, Lygate C
CIRCULATION. 2017;135(4):400-402.

Akrinor(TM), a Cafedrine/ Theodrenaline Mixture (20:1), Increases Force of Contraction of Human Atrial Myocardium But Does Not Constrict Internal Mammary Artery In Vitro
Kloth B, Pecha S, Moritz E, Schneeberger Y, Söhren K, Schwedhelm E, Reichenspurner H, Eschenhagen T, Böger R, Christ T, Stehr S
FRONT PHARMACOL. 2017;8:272.

Plasma Nitrate and Incidence of Cardiovascular Disease and All-Cause Mortality in the Community: The Framingham Offspring Study
Maas R, Xanthakis V, Göen T, Müller J, Schwedhelm E, Böger R, Vasan R
J AM HEART ASSOC. 2017;6(11):.

Asymmetric dimethylarginine and symmetric dimethylarginine prospectively relates to carotid wall thickening in black men - the SABPA study
Mels C, Schutte A, Huisman H, Smith W, Kruger R, Van Rooyen J, Schwedhelm E, Atzler D, Böger R, Malan N, Malan L
AMINO ACIDS. 2017;49(11):1843-1853.

Data on subgroup specific baseline characteristics and serum sphingosine-1-phosphate concentrations in the Study of Health in Pomerania
Moritz E, Wegner D, Groß S, Bahls M, Dörr M, Felix S, Ittermann T, Oswald S, Nauck M, Friedrich N, Böger R, Daum G, Schwedhelm E, Rauch B
Data Brief. 2017;12:46-50.

Reference intervals for serum sphingosine-1-phosphate in the population-based Study of Health in Pomerania
Moritz E, Wegner D, Groß S, Bahls M, Dörr M, Felix S, Ittermann T, Oswald S, Nauck M, Friedrich N, Böger R, Daum G, Schwedhelm E, Rauch B
CLIN CHIM ACTA. 2017;468:25-31.

A Label-Free Continuous Fluorescence-Based Assay for Monitoring Ornithine Decarboxylase Activity with a Synthetic Putrescine Receptor
Nilam M, Gribbon P, Reinshagen J, Cordts K, Schwedhelm E, Nau W, Hennig A
SLAS Discov. 2017;22(7):906-914.

Prasugrel as opposed to clopidogrel improves endothelial nitric oxide bioavailability and reduces platelet-leukocyte interaction in patients with unstable angina pectoris. A randomized controlled trial
Rudolph T, Fuchs A, Klinke A, Schlichting A, Friedrichs K, Hellmich M, Mollenhauer M, Schwedhelm E, Baldus S, Rudolph V
INT J CARDIOL. 2017;248:7-13.

Markers of nitric oxide are associated with sepsis severity: an observational study
Winkler M, Kluge S, Holzmann M, Moritz E, Robbe L, Bauer A, Zahrte C, Priefler M, Schwedhelm E, Böger R, Goetz A, Nierhaus A, Zoellner C
CRIT CARE. 2017;21(1):189.

Human leucocyte antigen (HLA-DR) gene expression is reduced in sepsis and correlates with impaired TNFα response: A diagnostic tool for immunosuppression?
Winkler M, Rissiek A, Priefler M, Schwedhelm E, Robbe L, Bauer A, Zahrte C, Zoellner C, Kluge S, Nierhaus A
PLOS ONE. 2017;12(8):e0182427.

Higher serum asymmetric dimethylarginine is related to higher risk of heart failure in the EPIC-Potsdam study
Wirth J, Atzler D, di Giuseppe R, Cordts K, Menzel J, Böger R, Boeing H, Weikert C, Schwedhelm E
AMINO ACIDS. 2017;49(1):173-182.

Cardiomyocyte dimethylarginine dimethylaminohydrolase-1 (DDAH1) plays an important role in attenuating ventricular hypertrophy and dysfunction
Xu X, Zhang P, Kwak D, Fassett J, Yue W, Atzler D, Hu X, Liu X, Wang H, Lu Z, Guo H, Schwedhelm E, Böger R, Chen P, Chen Y
BASIC RES CARDIOL. 2017;112(5):55.

Symmetric dimethylarginine, high-density lipoproteins and cardiovascular disease
Zewinger S, Kleber M, Rohrer L, Lehmann M, Triem S, Jennings R, Petrakis I, Dressel A, Lepper P, Scharnagl H, Ritsch A, Thorand B, Heier M, Meisinger C, de Las Heras Gala T, Koenig W, Wagenpfeil S, Schwedhelm E, Böger R, Laufs U, Eckardstein A, Landmesser U, Lüscher T, Fliser D, März W, Meinitzer A, Speer T
EUR HEART J. 2017;38(20):1597-1607.

2016

Reference intervals of plasma homoarginine from the German Gutenberg Health Study
Atzler D, Appelbaum S, Cordts K, Ojeda F, Wild P, Münzel T, Blankenberg S, Böger R, Blettner M, Beutel M, Pfeiffer N, Zeller T, Lackner K, Schwedhelm E
CLIN CHEM LAB MED. 2016;54(7):1231-7.

Low Homoarginine Levels in the Prognosis of Patients With Acute Chest Pain
Atzler D, Baum C, Ojeda F, Keller T, Cordts K, Schnabel R, Choe C, Lackner K, Münzel T, Böger R, Blankenberg S, Schwedhelm E, Zeller T
J AM HEART ASSOC. 2016;5(4):e002565.

Homoarginine predicts mortality in treatment-naive patients with pulmonary arterial hypertension
Atzler D, Cracowski J, Cordts K, Böger R, Humbert M, Schwedhelm E
INT J CARDIOL. 2016;217:12-5.

Oral supplementation with L-homoarginine in young volunteers
Atzler D, Schönhoff M, Cordts K, Ortland I, Hoppe J, Hummel F, Gerloff C, Jaehde U, Jagodzinski A, Böger R, Choe C, Schwedhelm E
BRIT J CLIN PHARMACO. 2016;82(6):1477-1485.

ADMA and arginine derivatives in relation to non-invasive vascular function in the general population
Baum C, Johannsen S, Zeller T, Atzler D, Ojeda F, Wild P, Sinning C, Lackner K, Gori T, Schwedhelm E, Böger R, Blankenberg S, Münzel T, Schnabel R
ATHEROSCLEROSIS. 2016;244:149-56.

Homoarginine and l-Arginine/Glycine Amidinotransferase in Stroke
Choe C, Schwedhelm E, Atzler D
2016. L-Arginine in Clinical Nutrition. Patel V, Preedy V, Rajendram R (Hrsg.). 1. Aufl. Springer International Publishing, 213-223.

Ranolazine antagonizes catecholamine-induced dysfunction in isolated cardiomyocytes, but lacks long-term therapeutic effects in vivo in a mouse model of hypertrophic cardiomyopathy
Flenner F, Friedrich F, Ungeheuer N, Christ T, Geertz B, Reischmann S, Wagner S, Stathopoulou K, Söhren K, Weinberger F, Schwedhelm E, Cuello F, Maier L, Eschenhagen T, Carrier L
CARDIOVASC RES. 2016;109(1):90-102.

L-Arginine Derivatives Are Associated with the Hyperthyroid State in the General Population
Ittermann T, Bahls M, Atzler D, Friedrich N, Schwedhelm E, Böger R, Felix S, Völzke H, Dörr M
THYROID. 2016;26(2):212-8.

Development of nonfibrotic left ventricular hypertrophy in an ANG II-induced chronic ovine hypertension model
Klatt N, Scherschel K, Schad C, Lau D, Reitmeier A, Kuklik P, Muellerleile K, Yamamura J, Zeller T, Steven D, Baldus S, Schäffer B, Jungen C, Eickholt C, Wassilew K, Schwedhelm E, Willems S, Meyer C
Physiol Rep. 2016;4(17):e12897.

The relationship of nitric oxide synthesis capacity, oxidative stress, and albumin-to-creatinine ratio in black and white men: the SABPA study
Mels C, Huisman H, Smith W, Schutte R, Schwedhelm E, Atzler D, Böger R, Ware L, Schutte A
AGE (DORDR). 2016;38(1):9.

Nitric oxide synthesis capacity, ambulatory blood pressure and end organ damage in a black and white Population: the SABPA study
Mels C, Loots I, Schwedhelm E, Atzler D, Böger R, Schutte A
AMINO ACIDS. 2016;48(3):801-10.

ADMA, subclinical changes and atrial fibrillation in the general population
Ramuschkat M, Appelbaum S, Atzler D, Zeller T, Bauer C, Ojeda F, Sinning C, Hoffmann B, Lackner K, Böger R, Wild P, Münzel T, Blankenberg S, Schwedhelm E, Schnabel R
INT J CARDIOL. 2016;203:640-6.

Asymmetric dimethylarginine, related arginine derivatives, and incident atrial fibrillation
Schnabel R, Maas R, Wang N, Yin X, Larson M, Levy D, Ellinor P, Lubitz S, McManus D, Magnani J, Atzler D, Böger R, Schwedhelm E, Vasan R, Benjamin E
AM HEART J. 2016;176:100-6.

Serum-Sphingosine-1-Phosphate Concentrations Are Inversely Associated with Atherosclerotic Diseases in Humans
Soltau I, Mudersbach E, Geissen M, Schwedhelm E, Winkler M, Geffken M, Peine S, Schoen G, Debus E, Larena-Avellaneda A, Daum G
PLOS ONE. 2016;11(12):e0168302.

Differential effects of nebivolol vs. metoprolol on microvascular function in hypertensive humans
Velasco A, Solow E, Price A, Wang Z, Arbique D, Arbique G, Adams-Huet B, Schwedhelm E, Lindner J, Vongpatanasin W
AM J PHYSIOL-HEART C. 2016;311(1):H118-24.

2015

L-homoarginine and cardiovascular disease
Atzler D, Schwedhelm E, Choe C
CURR OPIN CLIN NUTR. 2015;18(1):83-8.

L-Arginine and SDMA Serum Concentrations Are Associated with Subclinical Atherosclerosis in the Study of Health in Pomerania (SHIP)
Bahls M, Friedrich N, Atzler D, Felix S, Nauck M, Böger R, Völzke H, Schwedhelm E, Dörr M
PLOS ONE. 2015;10(6):Art. UNSP e0131293.

Measurement of homoarginine in human and mouse plasma by LC-MS/MS and ELISA: a comparison and a biological application
Cordts K, Atzler D, Qaderi V, Sydow K, Böger R, Choe C, Schwedhelm E
AMINO ACIDS. 2015;47(9):2015-22.

Biosynthesis of homoarginine (hArg) and asymmetric dimethylarginine (ADMA) from acutely and chronically administered free L-arginine in humans
Kayacelebi A, Langen J, Weigt-Usinger K, Chobanyan-Jürgens K, Mariotti F, Schneider J, Rothmann S, Frölich J, Atzler D, Choe C, Schwedhelm E, Huneau J, Lücke T, Tsikas D
AMINO ACIDS. 2015;47(9):1893-908.

FoxO1 regulates asymmetric dimethylarginine via downregulation of dimethylaminohydrolase 1 in human endothelial cells and subjects with atherosclerosis
Menghini R, Casagrande V, Cardellini M, Ballanti M, Davato F, Cardolini I, Stoehr R, Fabrizi M, Morelli M, Anemona L, Bernges I, Schwedhelm E, Ippoliti A, Mauriello A, Böger R, Federici M
ATHEROSCLEROSIS. 2015;242(1):230-5.

Homoarginine supplementation improves blood glucose in diet-induced obese mice
Stockebrand M, Hornig S, Neu A, Atzler D, Cordts K, Böger R, Isbrandt D, Schwedhelm E, Choe C
AMINO ACIDS. 2015;47(9):1921-9.

Decreased serum concentrations of sphingosine-1-phosphate in sepsis
Winkler M, Nierhaus A, Holzmann M, Mudersbach E, Bauer A, Robbe L, Zahrte C, Geffken M, Peine S, Schwedhelm E, Daum G, Kluge S, Zoellner C
CRIT CARE. 2015;19(1):372.

2014

Genetic and environmental determinants of dimethylarginines and association with cardiovascular disease in patients with type 2 diabetes
Anderssohn M, McLachlan S, Lüneburg N, Robertson C, Schwedhelm E, Williamson R, Strachan M, Ajjan R, Grant P, Böger R, Price J
DIABETES CARE. 2014;37(3):846-854.

Homoarginine and cardiovascular outcome in the population-based Dallas Heart Study
Atzler D, Gore M, Ayers C, Choe C, Böger R, de Lemos J, McGuire D, Schwedhelm E
ARTERIOSCL THROM VAS. 2014;34(11):2501-7.

Serum reference intervals of homoarginine, ADMA, and SDMA in the Study of Health in Pomerania
Atzler D, Schwedhelm E, Nauck M, Ittermann T, Böger R, Friedrich N
CLIN CHEM LAB MED. 2014;52(12):1835-1842.

Integrated genomics and metabolomics in nephrology
Atzler D, Schwedhelm E, Zeller T
NEPHROL DIAL TRANSPL. 2014;29(8):1467-1474.

Pathophysiology of isoprostanes in the cardiovascular System: implications of isoprostane-mediated thromboxane A2 receptor activation
Bauer J, Ripperger A, Frantz S, Ergün S, Schwedhelm E, Benndorf R
BRIT J PHARMACOL. 2014;171(13):3115-3131.

Genome-Wide Association Study of L-Arginine and Dimethylarginines Reveals Novel Metabolic Pathway for Symmetric Dimethylarginine
Lüneburg N, Lieb W, Zeller T, Chen M, Maas R, Carter A, Xanthakis V, Glazer N, Schwedhelm E, Seshadri S, Ikram M, Longstreth W, Fornage M, König I, Loley C, Ojeda Echevarria F, Schillert A, Wang T, Sticht H, Kittel A, König J, Benjamin E, Sullivan L, Bernges I, Anderssohn M, Ziegler A, Gieger C, Illig T, Meisinger C, Wichmann H, Wild P, Schunkert H, Psaty B, Wiggins K, Heckbert S, Smith N, Lackner K, Lunetta K, Blankenberg S, Erdmann J, Münzel T, Grant P, Vasan R, Böger R
CIRC-CARDIOVASC GENE. 2014.

Incidence of all-cause and cardiovascular mortality predicted by symmetric dimethylarginine in the population-based study of health in pomerania
Schwedhelm E, Wallaschofski H, Atzler D, Dörr M, Nauck M, Völker U, Kroemer H, Völzke H, Böger R, Friedrich N
PLOS ONE. 2014;9(5):e96875.

Association of multiple biomarkers and classical risk factors with early carotid atherosclerosis: results from the Gutenberg Health Study
Sinning C, Kieback A, Wild P, Schnabel R, Ojeda Echevarria F, Appelbaum S, Zeller T, Lubos E, Schwedhelm E, Lackner K, Debus E, Munzel T, Blankenberg S, Espinola-Klein C
CLIN RES CARDIOL. 2014;103(6):477-85.

Hamburger Pharmakologie-Repetitorium: Eine Übersicht klinisch relevanter arzneitherapeutischer Fakten
Wuttke A, Eschenhagen T, Hirt M, Hansen A, Stenzig J, Weinberger F, Werner U, Friedrich F, Schwedhelm E, Lüneburg N, Anderssohn M
2014. Hamburger Pharmakologie-Repetitorium. Wuttke A, Eschenhagen T (Hrsg.). 3. Aufl. Hamburg: Eigenverlag, .

2013

Homoarginine--an independent marker of mortality in heart failure
Atzler D, Rosenberg M, Anderssohn M, Choe C, Lutz M, Zugck C, Böger R, Frey N, Schwedhelm E
INT J CARDIOL. 2013;168(5):4907-9.

Increased symmetrical dimethylarginine in ischemic acute kidney injury as a causative factor of renal L-arginine deficiency
Betz B, Möller-Ehrlich K, Kress T, Kniepert J, Schwedhelm E, Böger R, Wanner C, Sauvant C, Schneider R
TRANSL RES. 2013;162(2):67-76.

Homoarginine levels are regulated by L-arginine:glycine amidinotransferase and affect stroke outcome: results from human and murine studies
Choe C, Atzler D, Wild P, Carter A, Böger R, Ojeda Echevarria F, Simova O, Stockebrand M, Lackner K, Nabuurs C, Marescau B, Streichert T, Müller C, Lüneburg N, De Deyn P, Benndorf R, Baldus S, Gerloff C, Blankenberg S, Heerschap A, Grant P, Magnus T, Zeller T, Isbrandt D, Schwedhelm E
CIRCULATION. 2013;128(13):1451-61.

Isoprostanes and neuroprostanes: total synthesis, biological activity and biomarkers of oxidative stress in humans
Galano J, Mas E, Barden A, Mori T, Signorini C, De Felice C, Barrett A, Opere C, Pinot E, Schwedhelm E, Benndorf R, Roy J, Le Guennec J, Oger C, Durand T
PROSTAGLANDINS OTHER LIPID MEDIAT. 2013;107:95-102.

A comparison of the association between glomerular filtration and L-arginine status in HIV-infected and uninfected African men: the SAfrEIC study.
Glyn M, Van Rooyen J, Schutte R, Huisman H, Böger R, Schwedhelm E, Lüneburg N, Mels C, Schutte A
J HUM HYPERTENS. 2013;27(9):557-563.

Symmetrical dimethylarginine predicts mortality in the general Population: observations from the Dallas heart study
Gore M, Lüneburg N, Schwedhelm E, Ayers C, Anderssohn M, Khera A, Atzler D, de Lemos J, Grant P, McGuire D, Böger R
ARTERIOSCL THROM VAS. 2013;33(11):2682-8.

Aliskiren accumulation in the kidney: no major role for binding to renin or prorenin
Lange S, Fraune C, Alenina N, Bader M, Danser A, Frenay A, van Goor H, Stahl R, Nguyen G, Schwedhelm E, Wenzel U
J HYPERTENS. 2013;31(4):713-9.

Asymmetric and symmetric dimethylarginine and risk of secondary cardiovascular disease events and mortality in patients with stable coronary heart disease: the KAROLA follow-up study.
Siegerink B, Maas R, Vossen C, Schwedhelm E, Koenig W, Böger R, Rothenbacher D, Brenner H, Breitling L
CLIN RES CARDIOL. 2013;102(3):193-202.

2012

The L-Arginine-asymmetric dimethylarginine ratio is an independent predictor of mortality in dilated cardiomyopathy.
Anderssohn M, Rosenberg M, Schwedhelm E, Zugck C, Lutz M, Lüneburg N, Frey N, Böger R
J CARD FAIL. 2012;18(12):904-911.

Dimethylarginines, homocysteine metabolism, and cerebrospinal fluid markers for Alzheimer's disease.
Arlt S, Schwedhelm E, Kölsch H, Jahn H, Linnebank M, Smulders Y, Jessen F, Böger R, Popp J
J ALZHEIMERS DIS. 2012;31(4):751-758.

Independent association of urinary F2-isoprostanes with survival in pulmonary arterial hypertension.
Cracowski J, Degano B, Chabot F, Labarère J, Schwedhelm E, Monneret D, Iuliano L, Schwebel C, Chaouat A, Reynaud-Gaubert M, Faure P, Maas R, Renversez J, Cracowski C, Sitbon O, Yaïci A, Simonneau G, Humbert M
CHEST. 2012;142(4):869-876.

AT1 antagonism and renin inhibition in mice: pivotal role of targeting angiotensin II in chronic kidney disease.
Fraune C, Lange S, Krebs C, Hölzel A, Baucke J, Divac N, Schwedhelm E, Streichert T, Velden J, Garrelds I, Danser A, Frenay A, van Goor H, Jankowski V, Stahl R, Nguyen G, Wenzel U
AM J PHYSIOL-RENAL. 2012;303(7):1037-1048.

Symmetric dimethylarginine is a marker of detrimental outcome in the acute phase after ischaemic stroke: role of renal function.
Lüneburg N, von Holten R, Töpper R, Schwedhelm E, Maas R, Böger R
CLIN SCI. 2012;122(3):105-111.

Myeloperoxidase deficiency preserves vasomotor function in humans.
Rudolph T, Wipper S, Reiter B, Rudolph V, Coym A, Detter C, Lau D, Klinke A, Friedrichs K, Rau T, Pekarova M, Russ D, Knöll K, Stubendorff M, Schroeder B, Wegscheider K, Andresen H, Schwedhelm E, Böger R, Ehmke H, Baldus S
EUR HEART J. 2012;33(13):1625-1634.

Dimethylarginine dimethylaminohydrolase1 is an organ-specific mediator of end organ damage in a murine model of hypertension.
Sydow K, Schmitz C, von Leitner E, von Leitner R, Klinke A, Atzler D, Krebs C, Wieboldt H, Ehmke H, Schwedhelm E, Meinertz T, Blankenberg S, Böger R, Magnus T, Baldus S, Wenzel U
PLOS ONE. 2012;7(10):48150.

2011

Stable isotope dilution assay for liquid chromatography-tandem mass spectrometric determination of L-homoarginine in human plasma.
Atzler D, Mieth M, Maas R, Böger R, Schwedhelm E
J CHROMATOGR B ANALYT TECHNOL BIOMED LIFE SCI. 2011;879(23):2294-2298.

Asymmetric dimethylarginine as an independent risk marker for mortality in ambulatory patients with peripheral arterial disease.
Böger R, Endres H, Schwedhelm E, Darius H, Atzler D, Lüneburg N, von Stritzky B, Maas R, Thiem U, Benndorf R, Diehm C
J INTERN MED. 2011;269(3):349-361.

Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine.
Hu X, Atzler D, Xu X, Zhang P, Guo H, Lu Z, Fassett J, Schwedhelm E, Böger R, Bache R, Chen Y
ARTERIOSCL THROM VAS. 2011;31(7):1540-1546.

Reference intervals for plasma L-arginine and the L-arginine:asymmetric dimethylarginine ratio in the Framingham Offspring Cohort.
Lüneburg N, Xanthakis V, Schwedhelm E, Sullivan L, Maas R, Anderssohn M, Riederer U, Glazer N, Vasan R, Böger R
J NUTR. 2011;141(12):2186-2190.

CLA does not impair endothelial function and decreases body weight as compared with safflower oil in overweight and obese male subjects.
Pfeuffer M, Fielitz K, Laue C, Winkler P, Rubin D, Helwig U, Giller K, Kammann J, Schwedhelm E, Böger R, Bub A, Bell D, Schrezenmeir J
J AM COLL NUTR. 2011;30(1):19-28.

The role of asymmetric and symmetric dimethylarginines in renal disease.
Schwedhelm E, Böger R
NAT REV NEPHROL. 2011;7(5):275-285.

Plasma symmetric dimethylarginine reference limits from the Framingham offspring cohort.
Schwedhelm E, Xanthakis V, Maas R, Sullivan L, Atzler D, Lüneburg N, Glazer N, Riederer U, Vasan R, Böger R
CLIN CHEM LAB MED. 2011;49(11):1907-1910.

Pathogenic cycle between the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine and the leukocyte-derived hemoprotein myeloperoxidase.
von Leitner E, Klinke A, Atzler D, Slocum J, Lund N, Kielstein J, Maas R, Schmidt-Haupt R, Pekarova M, Hellwinkel O, Tsikas D, D'Alecy L, Lau D, Willems S, Kubala L, Ehmke H, Meinertz T, Blankenberg S, Schwedhelm E, Gadegbeku C, Böger R, Baldus S, Sydow K
CIRCULATION. 2011;124(24):2735-2745.

2010

Asymmetric dimethylarginine as a mediator of vascular dysfunction and a marker of cardiovascular disease and mortality: an intriguing interaction with diabetes mellitus.
Anderssohn M, Schwedhelm E, Lüneburg N, Vasan R, Böger R
Diab Vasc Dis Res. 2010;7(2):105-118.

The role of nitric oxide synthase inhibition by asymmetric dimethylarginine in the pathophysiology of preeclampsia.
Böger R, Diemert A, Schwedhelm E, Lüneburg N, Maas R, Hecher K
GYNECOL OBSTET INVES. 2010;69(1):1-13.

Dimethylarginine dimethylaminohydrolase overexpression ameliorates atherosclerosis in apolipoprotein E-deficient mice by lowering asymmetric dimethylarginine.
Jacobi J, Maas R, Cardounel A, Arend M, Pope A, Cordasic N, Heusinger-Ribeiro J, Atzler D, Strobel J, Schwedhelm E, Böger R, Hilgers K
AM J PATHOL. 2010;176(5):2559-2570.

Symmetric dimethylarginine predicts all-cause mortality following ischemic stroke.
Schulze F, Carter A, Schwedhelm E, Ajjan R, Maas R, von Holten R, Atzler D, Grant P, Böger R
ATHEROSCLEROSIS. 2010;208(2):518-523.

Dimethylarginines: their vascular and metabolic roles in Africans and Caucasians.
Schutte A, Schutte R, Huisman H, Johannes V, Fourie C, Malan L, Malan N, Schwedhelm E, Strimbeanu S, Anderssohn M, Böger R
EUR J ENDOCRINOL. 2010;162(3):525-533.

Redox-generated isoprostanes are associated with residual platelet activity in aspirin-treated patients with stable coronary heart disease.
Schwedhelm E, Bierend A, Maas R, Trinks R, Kom G, Tsikas D, Böger R
J THROMB HAEMOST. 2010;8(12):2662-2670.

Rapid effect of single-dose rosiglitazone treatment on endothelial function in healthy men with normal glucose tolerance: data from a randomised, placebo-controlled, double-blind study.
Walcher T, Walcher D, Hetzel J, Mielke C, Rau M, Rittig K, Balletshofer B, Schwedhelm E, Hombach V, Böger R, Koenig W, Marx N
Diab Vasc Dis Res. 2010;7(3):178-185.

Interaction of angiotensin receptor type 1 blockers with ATP-binding cassette transporters.
Weiss J, Sauer A, Divac N, Herzog M, Schwedhelm E, Böger R, Haefeli W, Benndorf R
BIOPHARM DRUG DISPOS. 2010;31(2-3):150-161.

2009

Methylarginines and mortality in patients with end stage renal disease: a prospective cohort study.
Aucella F, Maas R, Vigilante M, Tripepi G, Schwedhelm E, Margaglione M, Gesualdo L, Boeger R, Zoccali C
ATHEROSCLEROSIS. 2009.

Angiotensin II type 2 receptor deficiency aggravates renal injury and reduces survival in chronic kidney disease in mice.
Benndorf R, Krebs C, Hirsch-Hoffmann B, Schwedhelm E, Cieslar G, Schmidt-Haupt R, Steinmetz O, Meyer-Schwesinger C, Thaiss F, Haddad M, Fehr S, Heilmann A, Helmchen U, Hein L, Ehmke H, Stahl R, Böger R, Wenzel U
KIDNEY INT. 2009;75(10):1039-1049.

Renal resistance index in renal allograft recipients: a role for ADMA.
Bergmann I, Böger R, Marti E, Frey F, Schwedhelm E, Eisenberger U
AM J KIDNEY DIS. 2009.

Asymmetric dimethylarginine (ADMA) as a prospective marker of cardiovascular disease and mortality-An update on patient populations with a wide range of cardiovascular risk.
Böger R, Maas R, Schulze F, Schwedhelm E
PHARMACOL RES. 2009;60(6):481-487.

Plasma asymmetric dimethylarginine and incidence of cardiovascular disease and death in the community.
Böger R, Sullivan Lisa M, Schwedhelm E, Wang T, Maas R, Benjamin E, Schulze F, Xanthakis V, Benndorf R, Vasan R
CIRCULATION. 2009;119(12):1592-1600.

Urinary excretion of biomarkers of oxidatively damaged DNA and RNA in hereditary hemochromatosis.
Broedbaek K, Poulsen H, Weimann A, Kom G, Schwedhelm E, Nielsen P, Böger R
FREE RADICAL BIO MED. 2009;47(8):1230-1233.

HNO exacerbates ischemic cerebral injury and oxidative neurotoxicity.
Choe C, Lewerenz J, Fischer G, Uliasz T, Espey M, Hummel F, Bruce King S, Schwedhelm E, Böger R, Gerloff C, Hewett S, Magnus T, Donzelli S
J NEUROCHEM. 2009.

Nitroxyl exacerbates ischemic cerebral injury and oxidative neurotoxicity
Choe C, Lewerenz J, Fischer G, Uliasz T, Espey M, Hummel F, King S, Schwedhelm E, Böger R, Gerloff C, Hewett S, Magnus T, Donzelli S
J NEUROCHEM. 2009;110(6):1766-73.

Vascular endothelial-specific dimethylarginine dimethylaminohydrolase-1-deficient mice reveal that vascular endothelium plays an important role in removing asymmetric dimethylarginine.
Hu X, Xu X, Zhu G, Atzler D, Kimoto M, Chen J, Schwedhelm E, Lüneburg N, Böger R, Zhang P, Chen Y
CIRCULATION. 2009;120(22):2222-2229.

Dimethylarginine dimethylaminohydrolase-1 transgenic mice are not protected from ischemic stroke.
Leypoldt F, Choe C, Gelderblom M, von Leitner E, Atzler D, Schwedhelm E, Gerloff C, Sydow K, Böger R, Magnus T
PLOS ONE. 2009;4(10):7337.

Plasma asymmetric dimethylarginine, L-arginine and left ventricular structure and function in a community-based sample.
Lieb W, Benndorf R, Benjamin E, Sullivan Lisa M, Maas R, Xanthakis V, Schwedhelm E, Aragam J, Schulze F, Böger R, Vasan R
ATHEROSCLEROSIS. 2009;204(1):282-287.

Polymorphisms in the promoter region of the dimethylarginine dimethylaminohydrolase 2 gene are associated with prevalence of hypertension.
Maas R, Erdmann J, Lüneburg N, Stritzke J, Schwedhelm E, Meisinger C, Peters A, Weil J, Schunkert H, Böger R, Lieb W
PHARMACOL RES. 2009;60(6):488-493.

Association of the Endogenous Nitric Oxide Synthase Inhibitor ADMA With Carotid Artery Intimal Media Thickness in the Framingham Heart Study Offspring Cohort.
Maas R, Xanthakis V, Polak J, Schwedhelm E, Sullivan Lisa M, Benndorf R, Schulze F, Vasan R, Wolf P, Böger R, Seshadri S
STROKE. 2009;40(8):2715-2719.

Quantification of arginine and its mono- and dimethylated analogs NMMA, ADMA and SDMA in biological fluids by LC-MS/MS: Is LC superfluous?
Martens-Lobenhoffer J, Schwedhelm E, Tsikas D
J CHROMATOGR B ANALYT TECHNOL BIOMED LIFE SCI. 2009;877(27):3261-3266.

Flow-mediated dilation in patients with coronary artery disease is enhanced by high dose atorvastatin compared to combined low dose atorvastatin and ezetimibe: results of the CEZAR study.
Ostad M, Eggeling S, Tschentscher P, Schwedhelm E, Böger R, Wenzel P, Meinertz T, Munzel T, Warnholtz A
ATHEROSCLEROSIS. 2009;205(1):227-232.

Association of plasma ADMA levels with MRI markers of vascular brain injury: Framingham offspring study.
Pikula A, Böger R, Beiser A, Maas R, DeCarli C, Schwedhelm E, Himali J, Schulze F, Au R, Kelly-Hayes M, Kase C, Vasan R, Wolf P, Seshadri S
STROKE. 2009;40(9):2959-2964.

L-Arginine enhances the triglyceride-lowering effect of simvastatin in patients with elevated plasma triglycerides.
Schulze F, Glos S, Petruschka D, Altenburg C, Maas R, Benndorf R, Schwedhelm E, Beil U, Böger R
NUTR RES. 2009;29(5):291-297.

Asymmetric dimethylarginine predicts outcome and time of stay in hospital in patients attending an internal medicine emergency room.
Schulze F, Vollert J, Maas R, Müller R, Schwedhelm E, Müller C, Böger R, Möckel M
CLIN CHIM ACTA. 2009;401(1-2):20-24.

Extensive characterization of the human DDAH1 transgenic mice.
Schwedhelm E, von Leitner E, Atzler D, Schmitz C, Jacobi J, Meinertz T, Münzel T, Baldus S, Cooke J, Böger R, Maas R, Sydow K
PHARMACOL RES. 2009;60(6):494-502.

Asymmetric dimethylarginine reference intervals determined with liquid chromatography-tandem mass spectrometry: results from the Framingham offspring cohort.
Schwedhelm E, Xanthakis V, Maas R, Sullivan Lisa M, Schulze F, Riederer U, Benndorf R, Böger R, Vasan R
CLIN CHEM. 2009.

A study of endothelial function and circulating asymmetric dimethylarginine levels in people with Type 1 diabetes without macrovascular disease or microalbuminuria.
Sibal L, Agarwal S, Schwedhelm E, Lüneburg N, Böger R, Home P
CARDIOVASC DIABETOL. 2009;8:27.

2008

Asymmetrical dimethylarginine is increased in plasma and decreased in cerebrospinal fluid of patients with Alzheimer's disease.
Arlt S, Schulze F, Eichenlaub M, Maas R, Lehmbeck J, Schwedhelm E, Jahn H, Böger R
DEMENT GERIATR COGN. 2008;26(1):58-64.

P2Y12 polymorphisms and antiplatelet effects of aspirin in patients with coronary artery disease.
Bierend A, Rau T, Maas R, Schwedhelm E, Böger R
BRIT J CLIN PHARMACO. 2008;65(4):540-547.

Antiproteinuric effects of angiotensin receptor blockers: telmisartan versus valsartan in hypertensive patients with type 2 diabetes mellitus and overt nephropathy.
Galle J, Schwedhelm E, Pinnetti S, Böger R, Wanner C
NEPHROL DIAL TRANSPL. 2008;23(10):3174-3183.

Simultaneous assessment of endothelial function, nitric oxide synthase activity, nitric oxide-mediated signaling, and oxidative stress in individuals with and without hypercholesterolemia.
Maas R, Schwedhelm E, Kahl L, Li H, Benndorf R, Lüneburg N, Förstermann U, Böger R
CLIN CHEM. 2008;54(2):292-300.

Effects of moderate hyperhomocysteinaemia induced by 4 weeks methionine-enriched diet on metabolite profile and mesenteric artery function in rats.
Pexa A, Böger R, Henle T, Schwedhelm E, Deussen A
BRIT J NUTR. 2008;99(5):993-999.

Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism.
Schwedhelm E, Maas R, Freese R, Jung D, Lukacs Z, Jambrecina A, Spickler W, Schulze F, Böger R
BRIT J CLIN PHARMACO. 2008;65(1):51-59.

2007

Pharmacokinetics of oral doses of telmisartan and nisoldipine, given alone and in combination, in patients with essential hypertension.
Bajcetic M, Benndorf R, Appel D, Schwedhelm E, Schulze F, Riekhof D, Maas R, Böger R
J CLIN PHARMACOL. 2007;47(3):295-304.

Telmisartan improves endothelial function in patients with essential hypertension.
Benndorf R, Appel D, Maas R, Schwedhelm E, Wenzel U, Böger R
J CARDIOVASC PHARM. 2007;50(4):367-371.

Mobilization of putative high-proliferative-potential endothelial colony-forming cells during antihypertensive treatment in patients with essential hypertension.
Benndorf R, Gehling U, Appel D, Maas R, Schwedhelm E, Schlagner K, Silberhorn E, Hossfeld D, Rogiers X, Böger R
STEM CELLS DEV. 2007;16(2):329-338.

Asymmetric dimethylarginine determines the improvement of endothelium-dependent vasodilation by simvastatin: Effect of combination with oral L-arginine.
Böger G, Rudolph T, Maas R, Schwedhelm E, Dumbadze E, Bierend A, Benndorf R, Böger R
J AM COLL CARDIOL. 2007;49(23):2274-2282.

Plasma concentrations of asymmetric dimethylarginine (ADMA) in metabolic syndrome.
Garcia R, Perez M, Maas R, Schwedhelm E, Böger R, López-Jaramillo P
INT J CARDIOL. 2007;122(2):176-178.

Impact of atorvastatin treatment on platelet-activating factor acetylhydrolase and 15-F(2trans)-isoprostane in hypercholesterolaemic patients.
Kom G, Schwedhelm E, Maas R, Schneider L, Benndorf R, Böger R
BRIT J CLIN PHARMACO. 2007;63(6):672-679.

Elevated plasma concentrations of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine predict adverse events in patients undergoing noncardiac surgery.
Maas R, Dentz L, Schwedhelm E, Thoms W, Kuß O, Hiltmeyer N, Haddad M, Klöss T, Standl T, Böger R
CRIT CARE MED. 2007;35(8):1876-1881.

Asymmetrical dimethylarginine (ADMA) and coronary endothelial function in patients with coronary artery disease and mild hypercholesterolemia.
Maas R, Quitzau K, Schwedhelm E, Spieker L, Rafflenbeul W, Steenpass A, Lüscher T, Böger R
ATHEROSCLEROSIS. 2007;191(1):211-219.

Asymmetric dimethylarginine, smoking, and risk of coronary heart disease in apparently healthy men: prospective analysis from the population-based Monitoring of Trends and Determinants in Cardiovascular Disease/Kooperative Gesundheitsforschung in der Region Augsburg study and experimental data.
Maas R, Schulze F, Baumert J, Löwel H, Hamraz K, Schwedhelm E, Koenig W, Böger R
CLIN CHEM. 2007;53(4):693-701.

A stable-isotope based technique for the determination of dimethylarginine dimethylaminohydrolase (DDAH) activity in mouse tissue.
Maas R, Tan-Andreesen J, Schwedhelm E, Schulze F, Böger R
J CHROMATOGR B ANALYT TECHNOL BIOMED LIFE SCI. 2007;851(1-2):220-228.

Acute effects of various fast-food meals on vascular function and cardiovascular disease risk markers: the Hamburg Burger Trial.
Rudolph T, Ruempler K, Schwedhelm E, Tan-Andresen J, Riederer U, Böger R, Maas R
AM J CLIN NUTR. 2007;86(2):334-340.

High-throughput liquid chromatographic-tandem mass spectrometric determination of arginine and dimethylated arginine derivatives in human and mouse plasma.
Schwedhelm E, Maas R, Tan-Andresen J, Schulze F, Riederer U, Böger R
J CHROMATOGR B ANALYT TECHNOL BIOMED LIFE SCI. 2007;851(1-2):211-219.

AT1-receptor blockade with irbesartan improves peripheral but not coronary endothelial dysfunction in patients with stable coronary artery disease.
Warnholtz A, Ostad M, Heitzer T, Thuneke F, Fröhlich M, Tschentscher P, Schwedhelm E, Böger R, Meinertz T, Munzel T
ATHEROSCLEROSIS. 2007;194(2):439-445.

2006

Telmisartan improves insulin sensitivity in nondiabetic patients with essential hypertension.
Benndorf R, Rudolph T, Appel D, Schwedhelm E, Maas R, Schulze F, Silberhorn E, Böger R
METABOLISM. 2006;55(9):1159-1164.

Postocclusive reactive hyperemia inversely correlates with urinary 15-F2t-isoprostane levels in systemic sclerosis.
Cracowski J, Kom G, Salvat-Melis M, Renversez J, McCord G, Boignard A, Carpentier P, Schwedhelm E
FREE RADICAL BIO MED. 2006;40(10):1732-1737.

Clopidogrel improves systemic endothelial nitric oxide bioavailability in patients with coronary artery disease: evidence for antioxidant and antiinflammatory effects.
Heitzer T, Rudolph V, Schwedhelm E, Karstens M, Sydow K, Ortak M, Tschentscher P, Meinertz T, Böger R, Baldus S
ARTERIOSCL THROM VAS. 2006;26(7):1648-1652.

Increased urinary excretion of 8-iso-prostaglandin F2alpha in patients with HFE-related hemochromatosis: a case-control study.
Kom G, Schwedhelm E, Nielsen P, Böger R
FREE RADICAL BIO MED. 2006;40(7):1194-1200.

Asymmetric dimethylarginine is an independent risk factor for coronary heart disease: results from the multicenter Coronary Artery Risk Determination investigating the Influence of ADMA Concentration (CARDIAC) study.
Schulze F, Lenzen H, Hanefeld C, Bartling A, Osterziel K, Goudeva L, Schmidt-Lucke C, Kusus M, Maas R, Schwedhelm E, Strödter D, Simon B, Mügge A, Daniel W, Tillmanns H, Maisch B, Streichert T, Böger R
AM HEART J. 2006;152(3):1-8.

Comparison of HPLC method and commercial ELISA assay for asymmetric dimethylarginine (ADMA) determination in human serum.
Schulze F, Schwedhelm E, Maas R, Böger R
J CHROMATOGR B ANALYT TECHNOL BIOMED LIFE SCI. 2006;831(1-2):333.

Direct technique for the fabrication of acrylic provisional restorations.
Schwedhelm E
J Contemp Dent Pract. 2006;7(1):157-173.

A technique for locating implant abutment screws of posterior cement-retained metal-ceramic restorations with ceramic occlusal surfaces.
Schwedhelm E, Raigrodski A
J PROSTHET DENT. 2006;95(2):165-167.

2005

Elevated levels of asymmetric dimethylarginine (ADMA) as a marker of cardiovascular disease and mortality.
Böger R, Maas R, Schulze F, Schwedhelm E
CLIN CHEM LAB MED. 2005;43(10):1124-1129.

ADMA and oxidative stress may relate to the progression of renal disease: rationale and design of the VIVALDI study.
Böger R, Schwedhelm E, Maas R, Quispe-Bravo S, Skamira C
VASC MED. 2005;10(1):97-102.

FK778 and tacrolimus prevent the development of obliterative airway disease after heterotopic rat tracheal transplantation.
Deuse T, Schrepfer S, Koch-Nolte F, Haddad M, Schwedhelm E, Böger R, Schäfer H, Detter C, Reichenspurner H
J HEART LUNG TRANSPL. 2005;24(11):1844-1854.

Elevation of asymmetrical dimethylarginine (ADMA) and coronary artery disease in men with erectile dysfunction.
Maas R, Wenske S, Zabel M, Ventura R, Schwedhelm E, Steenpass A, Klemm H, Noldus J, Böger R
EUR UROL. 2005;48(6):1002-1004.

Determination of a reference value for N(G), N(G)-dimethyl-L-arginine in 500 subjects.
Schulze F, Maas R, Freese R, Schwedhelm E, Silberhorn E, Böger R
EUR J CLIN INVEST. 2005;35(10):622-626.

Quantification of ADMA: analytical approaches.
Schwedhelm E
VASC MED. 2005;10(1):89-95.

Liquid chromatography-tandem mass spectrometry method for the analysis of asymmetric dimethylarginine in human plasma.
Schwedhelm E, Tan-Andresen J, Maas R, Riederer U, Schulze F, Böger R
CLIN CHEM. 2005;51(7):1268-1271.

Unusual collision-induced dissociation of fluorated and non-fluorated alpha-nitrotoluene analogs in a gas chromatograph triple-stage quadrupole mass spectrometer under electron-capturing negative-ion chemical ionization conditions.
Tsikas D, Schwedhelm E, Frölich J
J CHROMATOGR A. 2005;1067(1-2):337-345.

2004

Determination of NG,NG-dimethyl-L-arginine, an endogenous NO synthase inhibitor, by gas chromatography-mass spectrometry.
Albsmeier J, Schwedhelm E, Schulze F, Kastner M, Böger R
J CHROMATOGR B ANALYT TECHNOL BIOMED LIFE SCI. 2004;809(1):59-65.

[Biomarkers as prognostic factors in pulmonary arterial hypertension. Rationale and study design]
Cracowski J, Yaici A, Sitbon O, Reynaud-Gaubert M, Renversez J, Pison C, Faure P, Cracowski C, Chouri N, Chaouat A, Chabot F, Schwedhelm E, Maas R, Degano B, Mornex J, Humbert M
REV MAL RESPIR. 2004;21(6 Pt 1):1137-1143.

FK778 attenuates lymphocyte-endothelium interaction after cardiac transplantation: in vivo and in vitro studies.
Deuse T, Schrepfer S, Schäfer H, Koch-Nolte F, Schwedhelm E, Böger R, Reichenspurner H
TRANSPLANTATION. 2004;78(1):71-77.

Acetylsalicylic acid inhibits monocyte adhesion to endothelial cells by an antioxidative mechanism.
Eisele G, Schwedhelm E, Schieffer B, Tsikas D, Böger R
J CARDIOVASC PHARM. 2004;43(4):514-521.

Plasma concentrations of asymmetric dimethylarginine (ADMA) in Colombian women with pre-eclampsia.
Maas R, Böger R, Schwedhelm E, Casas J, López-Jaramillo P, Serrano N, Díaz L
JAMA-J AM MED ASSOC. 2004;291(7):823-824.

Comparative effects of AT1-antagonism and angiotensin-converting enzyme inhibition on markers of inflammation and platelet aggregation in patients with coronary artery disease.
Schieffer B, Bünte C, Witte J, Hoeper K, Böger R, Schwedhelm E, Drexler H
J AM COLL CARDIOL. 2004;44(2):362-368.

Determination of asymmetric dimethylarginine (ADMA) using a novel ELISA assay.
Schulze F, Wesemann R, Schwedhelm E, Sydow K, Albsmeier J, Cooke J, Böger R
CLIN CHEM LAB MED. 2004;42(12):1377-1383.

Urinary 8-iso-prostaglandin F2alpha as a risk marker in patients with coronary heart disease: a matched case-control study.
Schwedhelm E, Bartling A, Lenzen H, Tsikas D, Maas R, Brümmer J, Gutzki F, Berger J, Frölich J, Böger R
CIRCULATION. 2004;109(7):843-848.

2003

Application of gas chromatography-mass spectrometry for analysis of isoprostanes: their role in cardiovascular disease.
Schwedhelm E, Böger R
CLIN CHEM LAB MED. 2003;41(12):1552-1561.

A crown venting technique for the cementation of implant-supported crowns.
Schwedhelm E, Lepe X, Aw T
J PROSTHET DENT. 2003;89(1):89-90.

Clinical pharmacokinetics of antioxidants and their impact on systemic oxidative stress.
Schwedhelm E, Maas R, Troost R, Böger R
CLIN PHARMACOKINET. 2003;42(5):437-459.

ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst(e)inemia: effects of L-arginine and B vitamins.
Sydow K, Schwedhelm E, Arakawa N, Bode-Böger S, Tsikas D, Hornig B, Frölich J, Böger R
CARDIOVASC RES. 2003;57(1):244-252.

Accurate quantification of basal plasma levels of 3-nitrotyrosine and 3-nitrotyrosinoalbumin by gas chromatography-tandem mass spectrometry.
Tsikas D, Schwedhelm E, Stutzer F, Gutzki F, Iris R, Mehls C, Frölich J
J CHROMATOGR B ANALYT TECHNOL BIOMED LIFE SCI. 2003;784(1):77-90.

Divergence in urinary 8-iso-PGF(2alpha) (iPF(2alpha)-III, 15-F(2t)-IsoP) levels from gas chromatography-tandem mass spectrometry quantification after thin-layer chromatography and immunoaffinity column chromatography reveals heterogeneity of 8-iso-PGF(2alpha). Possible methodological, mechanistic and clinical implications.
Tsikas D, Schwedhelm E, Suchy M, Niemann J, Gutzki F, Erpenbeck V, Hohlfeld J, Surdacki A, Frölich J
J CHROMATOGR B ANALYT TECHNOL BIOMED LIFE SCI. 2003;794(2):237-255.

2002

The pathophysiology of erectile dysfunction related to endothelial dysfunction and mediators of vascular function.
Maas R, Schwedhelm E, Albsmeier J, Böger R
VASC MED. 2002;7(3):213-225.

Methodological considerations on the detection of 3-nitrotyrosine in the cardiovascular system.
Tsikas D, Schwedhelm E, Frölich J
CIRC RES. 2002;90(6):70.

2000

Normal oxidative stress and enhanced lipoprotein resistance to in vitro oxidation in hypertriglyceridemia: effects of bezafibrate therapy.
de Man F, Jonkers I, Schwedhelm E, Smelt A, Onkenhout W, VanDDuyvenvoorde W, Buytenhek R, Leuven J, Troost R, van Der Laarse A, Princen H
ARTERIOSCL THROM VAS. 2000;20(11):2434-2440.

Tandem mass spectrometric quantification of 8-iso-prostaglandin F2alpha and its metabolite 2,3-dinor-5,6-dihydro-8-iso-prostaglandin F2alpha in human urine.
Schwedhelm E, Tsikas D, Durand T, Gutzki F, Guy A, Rossi J, Frölich J
J CHROMATOGR B ANALYT TECHNOL BIOMED LIFE SCI. 2000;744(1):99-112.

Nebivolol decreases systemic oxidative stress in healthy volunteers.
Troost R, Schwedhelm E, Rojczyk S, Tsikas D, Frölich J
BRIT J CLIN PHARMACO. 2000;50(4):377-379.

Letzte Aktualisierung aus dem FIS: 03.12.2021 - 00:36 Uhr