Experimental Electrophysiology and Neuroimaging (xENi)

  • xENi
  • xENi

    Das xENi Labor beschäftigt sich mit der neuronalen Kontrolle von Sensomotorik im menschlichen Gehirn. Unser Ziel ist es, die Mechanismen neuroplastischer Anpassungsvorgänge zu verstehen. Diese bilden die Grundlage für sensomotorisches Lernen, kontextgerechte Auswahl von Aktionen und die Erholung nach zerebralen Läsionen (z.B. Schlaganfall).

    Unsere Hauptkompetenz liegt in der elektrophysiologischen und bildmorphologischen Darstellung physiologischer und pathologischer zerebraler Funktionen. Zur Messung von Hirnaktivität bei Patienten und gesunden Versuchspersonen wird ein multimodaler Ansatz moderner Imaging-Verfahren angewandt:

    • Multi-Kanal-EEG
    • neuronavigierte transkranielle Magnetstimulation (TMS)
    • funktionelle Kernspintomographie (fMRT)
    • transkranielle Gleichstromstimulation (tDCS)

  • Head of the group

    Prof. Dr. med. Christian Gerloff

    Academic and research staff

    • Dr. med. Gunnar Birke
    • Dr. med. Marlene Bönstrup
    • Dr. med. Dipl. phys. Hanna Braaß
    • Dipl.-Inf. Jan-Frederik Feldheim
    • Stephanie Guder
    • Focko Higgen
    • Dr. med. Lutz Krawinkel
    • Dr. med. Robert Schulz
    • Jan Timmermann
    • Dr. med. Fanny Quandt
    • Silke Wolf, MSc
    • Dr. rer. biol. hum. Winifried Backhaus

    Doctoral students

    • cand. med. Julia Forisch
    • cand. med. Dilan Aytan
    • cand. med. Eirene Ismene Germanidis

    Research assistents

    • Meike Mund
    • Antonia Ramin

  • Für unsere laufenden Projekte suchen wir jederzeit neue Versuchsteilnehmer. Diese helfen uns, durch den Vergleich mit anderen gesunden Probanden und mit erkrankten Patienten ein immer genaueres Bild der funktionellen Aufgaben des Gehirns und seiner Veränderungsmöglichkeiten nach Erkrankungen (z.B. Schlaganfall) zu verstehen. Wir möchten erreichen, daß auch nach einer so schweren Erkrankung wie einem Schlaganfall eine größtmögliche Wiedereingliederung in das alltägliche Umfeld möglich wird. Für Ihre Unterstützung dazu wären wir sehr dankbar.

    Natürlich wird Ihnen die Teilnahme finanziell vergütet. Bei Interesse melden Sie sich bitte unter +49 (0) 40 7410 - 53772 . Vielen Dank!

Stroke recovery

  • XENI SFB
    SFB 936 - project C1

    This project is geared to understand dynamic changes of multi-site communication, especially of ‘small-world network’ properties of the sensorimotor system, in the course of hand motor recovery after stroke. In a longitudinal design, connectivity will be measured with functional magnetic resonance imaging (fMRI), electroencephalography (EEG), and transcranial magnetic stimulation (TMS) in 60 patients. It is the project’s goal to create a statistical model of stroke recovery which can predict functional outcome, e.g., providing odds ratios for good recovery of dexterity. Beyond this, a computational model of the neural network serves motor control will be designed to simulate prospectively the effects of focal brain lesions on neural activity and behavior.


    Funding

    Sonderforschungsbereich 936 “Multi-Site Communication in the Brain“


    Publications

    Bönstrup M, Schulz R, Cheng B, Feldheim J, Zimerman M, Thomalla G, Hummel FC, Gerloff C (2015) Evolution of brain activation after stroke in a constant-effort versus constant-output motor task. Restor Neurol Neurosci. 2015;33(6):845-64. doi: 10.3233/RNN-150527.

    Schulz R, Frey BM, Koch P, Zimerman M, Bönstrup M, Feldheim J, Timmermann JE, Schön G, Cheng B, Thomalla G, Gerloff C, Hummel FC (2015) Cortico-Cerebellar Structural Connectivity Is Related to Residual Motor Output in Chronic Stroke. Cereb Cortex. 2015 Oct 27. pii: bhv251. [Epub ahead of print]

    Bönstrup M, Schulz R, Feldheim J, Hummel FC, Gerloff C (2015) Dynamic causal modelling of EEG and fMRI to characterize network architectures in a simple motor task. Neuroimage. 2016 Jan 1;124(Pt A):498-508. doi: 10.1016/j.neuroimage.2015.08.052.

    Schulz R, Braass H, Liuzzi G, Hoerniss V, Lechner P, Gerloff C, Hummel FC (2015) White matter integrity of premotor-motor connections is associated with motor output in chronic stroke patients. Neuroimage Clin. 2014 Nov 18;7:82-6. doi: 10.1016/j.nicl.2014.11.006.

    Zavaglia M, Forkert ND, Cheng B, Gerloff C, Thomalla G, Hilgetag CC (2015) Mapping causal functional contributions derived from the clinical assessment of brain damage after stroke. Neuroimage Clin. 2015 Aug 1;9:83-94. doi: 10.1016/j.nicl.2015.07.009.

    Boenstrup M, Feldheim J, Heise K, Gerloff C, Hummel FC (2014) The control of complex finger movements by directional information flow between mesial frontocentral areas and the primary motor cortex. Eur J Neurosci. 2014 Sep;40(6):2888-97. doi: 10.1111/ejn.12657.

    Cheng B, Forkert ND, Zavaglia M, Hilgetag CC, Golsari A, Siemonsen S, Fiehler J, Pedraza S, Puig J, Cho TH, Alawneh J, Baron JC, Ostergaard L, Gerloff C, Thomalla G (2014) Influence of stroke infarct location on functional outcome measured by the modified Rankin Scale. Stroke. 2014 Jun;45(6):1695-702. doi: 10.1161/STROKEAHA.114.005152.

    Liuzzi G, Hörniß V, Lechner P, Hoppe J, Heise K, Zimerman M, Gerloff C, Hummel FC (2014) Development of movement-related intracortical inhibition in acute to chronic subcortical stroke. Neurology. 2014 Jan 21;82(3):198-205. doi: 10.1212/WNL.0000000000000028.

    Schröder J, Cheng B, Ebinger M, Köhrmann M, Wu O, Kang DW, Liebeskind DS, Tourdias T, Singer OC, Christensen S, Campbell B, Luby M, Warach S, Fiehler J, Fiebach JB, Gerloff C, Thomalla G (2014) Validity of acute stroke lesion volume estimation by diffusion-weighted imaging-Alberta Stroke Program Early Computed Tomographic Score depends on lesion location in 496 patients with middle cerebral artery stroke. Stroke. 2014 Dec;45(12):3583-8. doi: 10.1161/STROKEAHA.114.006694.

    Engel AK, Gerloff C, Hilgetag CC, Nolte G (2013) Intrinsic coupling modes: multiscale interactions in ongoing brain activity. Neuron. 2013 Nov 20;80(4):867-86. doi: 10.1016/j.neuron.2013.09.038

    Schulz R, Park CH, Boudrias MH, Gerloff C, Hummel FC, Ward NS (2012) Assessing the integrity of corticospinal pathways from primary and secondary cortical motor areas after stroke. Stroke. 2012 Aug;43(8):2248-51. doi: 10.1161/STROKEAHA.112.662619.

    Thomalla G, Cheng B, Ebinger M, Hao Q, Tourdias T, Wu O, Kim JS, Breuer L, Singer OC, Warach S, Christensen S, Treszl A, Forkert ND, Galinovic I, Rosenkranz M, Engelhorn T, Köhrmann M, Endres M, Kang DW, Dousset V, Sorensen AG, Liebeskind DS, Fiebach JB, Fiehler J, Gerloff C (2011). DWIFLAIR mismatch for the identification of patients with acute ischaemic stroke within 4·5 h of symptom onset (PRE-FLAIR): a multicentre observational study. Lancet Neurol. 2011 Nov;10(11):978-86. doi: 10.1016/S1474-4422(11)70192-2.

  • The overall goal of this project is to understand adaptive changes of the cerebral motor network after stroke. In the first funding period, a central multimodal stroke database has been created and various network analyses have been implemented (DCM for fMRI/EEG, graph and game theory, machine learning, oscillator models). In the second funding period, different types of network characterization will be compared and related to clinical parameters. To move on towards causal relations between network dynamics and behavior, we will modulate networks with non-invasive brain stimulation, measure the effects, and apply modeling to predict them. With this thematic continuation and extension into modeling, modulation, and simulation, the project will move towards network-based, individualized outcome prediction and therapeutical applications.


    Funding

    Sonderforschungsbereich 931 “Multi-Site Interactions in the Brain“


    Publications

    Schulz R, Buchholz A, Frey BM, Bönstrup M, Cheng B, Thomalla G, Hummel FC, Gerloff C (2016) Enhanced Effective Connectivity Between Primary Motor Cortex and Intraparietal Sulcus in Well-Recovered Stroke Patients. Stroke. 2016 Feb;47(2):482-9. doi: 10.1161/STROKEAHA.115.011641.

    Finger H, Bönstrup M, Cheng B, Messé A, Hilgetag C, Thomalla G, Gerloff C, König P (2016) Modeling of Large-Scale Functional Brain Networks Based on Structural Connectivity from DTI: Comparison with EEG Derived Phase Coupling Networks and Evaluation of Alternative Methods along the Modeling Path. PLoS Comput Biol. 2016 Aug 9;12(8):e1005025. doi: 10.1371/journal.pcbi.1005025.

    Zavaglia M, Forkert ND, Cheng B, Gerloff C, Thomalla G, Hilgetag CC (2016) Technical considerations of a game-theoretical approach for lesion symptom mapping. BMC Neurosci. 2016 Jun 27;17(1):40. doi: 10.1186/s12868-016-0275-6.

  • XENINETS
    NETS study

    We aim to optimize the functional outcome after ischemic lesion affecting the upper extremity. Based on previous studies showing a beneficial effect of tDCS on hand motor function in chronic stroke patients we initiated a European multicentre, randomized controlled clinical trial (NETS). The double-blind interventional trial investigates the hypothesis that tDCS combined with functional training will enhance upper limb recovery in subacute stroke patients after their first-ever stroke. Eight centres are cooperating including centres in Northern and Southern Germany, as well as in Italy, Rome.


    Funding

    Deutsche Forschungsgemeinschaft; ClinicalTrials.gov Identifier: NCT00909714


    Publications

    Wessel MJ, Zimerman M, Timmermann JE, Heise KF, Gerloff C, Hummel FC (2015) Enhancing Consolidation of a New Temporal Motor Skill by Cerebellar Noninvasive Stimulation. Cereb Cortex. 2016 Apr;26(4):1660-7. doi: 10.1093/cercor/bhu335.

    Heise KF, Niehoff M, Feldheim JF, Liuzzi G, Gerloff C, Hummel FC (2014) Differential behavioral and physiological effects of anodal transcranial direct current stimulation in healthy adults of younger and older age. Front Aging Neurosci. 2014 Jul 10;6:146. doi: 10.3389/fnagi.2014.00146.

    Hummel FC, Gerloff C (2012) Transkranielle Hirnstimulation nach Schlaganfall. Nervenarzt. 2012 Aug:83(8):957-965. doi:10.1007/s00115-012-3566-x.

    Schulz R, Gerloff C, Hummel FC (2012) Non-invasive brain stimulation in neurological diseases. Neuropharmacology. 2013 Jan;64:579-87. doi: 10.1016/j.neuropharm.2012.05.016.

    Zimerman M, Heise KF, Hoppe J, Cohen LG, Gerloff C, Hummel FC (2012) Modulation of Training by Single-Session Transcranial Direct Current Stimulation to the Intact Motor Cortex Enhances Motor Skill Acquisition of the Paretic Hand. Stroke. 2012 Aug;43(8):2185-91. doi: 10.1161/STROKEAHA.111.645382.

    Gerloff C, Brandt SA (2010) Pro und Kontra: Kann Hirnstimulation die Erholung nach Schlaganfall fördern? INFO Neurologie & Psychiatrie 12 (4), 2-5.

    Hummel FC, Celnik P, Pascual-Leone A, Fregni F, Byblow WD, Butefisch C, Rothwell J, Cohen LG, Gerloff C (2008) Controversy: Noninvasive and invasive cortical stimulation show efficacy in treating stroke patients. Brain Stimul. 2008 Oct;1(4):370-82. doi: 10.1016/j.brs.2008.09.003.

    Hummel F, Celnik P, Giraux P, Floel A, Wan-Hsun Wu WH, Gerloff C, Cohen LG (2005) Effects of noninvasive cortical stimulation on skilled motor function in chronic stroke. Brain. 2005 Mar;128(Pt 3):490-9.

  • XENI Improve
    Lupe zum Vergrößern des Bildes
    Treffen der Kooperationspartner im März 2017

    Ziel dieses Projektes ist es, Erkenntnisse über Neuroplastizität und die Mechanismen des Wiedererlernens von Funktionen nach einem Schlaganfall aus dem Labor in die Praxis zu transferieren. In Kooperation mit den Rehabilitationskliniken RehaCentrum Hamburg, dem Klinikum Bad Bramstedt, dem MediClin Klinikum Soltau sowie der Helios Klinik Geesthacht findet zunächst eine Evaluation der aktuellen Praxis der Neurorehabilitation statt. In einem zweiten Schritt werden wir neurophysiologische und Imaging-basierte Biomarker für die Prognose des Rehabilitationsergebnisses mit Fokus auf der Handfunktion untersuchen. Im Weiteren soll der Einfluss evidenzbasierter Patienteninformation auf das Rehabilitationsergebnis analysiert werden. Auf Grundlage dieser Ergebnisse sollen neue therapeutische Ansätze wie nicht-invasive Hirnstimulation und Eigentraining zu Hause erforscht und Algorithmen für personalisierte Therapiepfade für Schlaganfallpatienten entwickelt werden.

    This project aimsat tranferring knowledge and expertise about neuroplasticity and recovery mechanisms after stroke from an experimental level into clinical practice. In a cooperation with the rehabilitation clinics RehaCentrum Hamburg, Klinikum Bad Bramstedt, Klinikum Soltau and Helios Klinik Geesthacht an evaluation of the current practice of rehabilitation of stroke patients in the post-acute phase is undertaken. As a second step we will investigate neurophysiological and imaging-based biomarkers for the prognosis of rehabilitation outcome with a focus on hand function. Furthermore, the influence of evidence-based patient information on the rehabilitation outcome will be studied. Based on these results new therapeutic approaches like non-invasive brain stimulation and home-based training will be investigated to develop algorithms of personalised therapy protocols for stroke patients.


    Funding

    Deutsche Rentenversicherung Nord

Multisensory integration and motor learning in the aging brain

  • XENI Integration
    Lupe zum Vergrößern des Bildes
    Scheme of TRR 169

    In this project, we examine the neural dynamics of crossmodal learning in healthy elderly individuals. We analyze neural signals associated with visuo-tactile integration and learning using EEG and MEG. Furthermore, we employ non-invasive brain stimulation to modulate related brain areas in attempt to enhance performance and aim to build computational models accounting for age-related differences. Our investigations will focus specifically on oscillatory neural activity and large-scale dynamic coupling between brain regions.


    Funding

    The Transregional Collaborative Research Centre TRR169 “Crossmodal Learning: Adaptivity, Prediction and Interaction” is funded by the German Research Foundation (DFG) and the National Science Foundation of China (NSFC)


    Publications

    Quandt, F., Bönstrup, M., Schulz, R., Timmermann, J., Zimerman, M., Nolte, G., Hummel, F., 2016. Spectral Variability in the Aged Brain during Fine Motor Control. Front Aging Neurosci 8, 305. doi:10.3389/fnagi.2016.00305

    Engel A K, Gerloff C, Hilgetag, CC, Nolte G (2013) Intrinsic coupling modes: multiscale interactions in ongoing brain activity. Neuron. 2013 Nov 20;80(4):867-86. doi: 10.1016/j.neuron.2013.09.038.

    Heise, KF, Zimerman M, Hoppe J, Gerloff C, Wegscheider K,Hummel FC (2013) The aging motor system as a model for plastic changes of GABA-mediated intracortical inhibition and their behavioral relevance. J Neurosci. 2013 May 22;33(21):9039-49. doi: 10.1523/JNEUROSCI.4094-12.2013.

    Hummel F, Celnik P, Giraux P, Floel A, Wu WH, Gerloff C,Cohen LG (2005) Effects of non-invasive cortical stimulation on skilled motor function in chronic stroke. Brain. 2005 Mar;128(Pt 3):490-9.

    Hummel F,Gerloff C (2005) Larger interregional synchrony is associated with greater behavioral success in a complex sensory integration task in humans. Cereb Cortex. 2005 May;15(5):670-8.

    Hummel FC, Heise K, Celnik P, Floel A, Gerloff C,Cohen LG (2010) Facilitating skilled right hand motor function in older subjects by anodal polarization over the left primary motor cortex. Neurobiol Aging. 2010 Dec;31(12):2160-8. doi: 10.1016/j.neurobiolaging.2008.12.008.

    Krawinkel L.A, Engel AK.,Hummel FC (2015) Modulating pathological oscillations by rhythmic non-invasive brain stimulation-a therapeutic concept? Front Syst Neurosci. 2015 Mar 17;9:33. doi: 10.3389/fnsys.2015.00033.

    Sailer A, Dichgans J, Gerloff C (2000) The influence of normal aging on the cortical processing of a simple motor task [In Process Citation]. Neurology. 2000 Oct 10;55(7):979-85.

    Schulz R, Zimerman M, Timmermann J E, Wessel MJ, Gerloff, C,Hummel FC (2014) White matter integrity of motor connections related to training gains in healthy aging. Neurobiol Aging. 2014 Jun;35(6):1404-11. doi: 10.1016/j.neurobiolaging.2013.11.024.

    Zimerman M, Heise KF, Gerloff C, Cohen LG,Hummel FC (2014) Disrupting the ipsilateral motor cortex interferes with training of a complex motor task in older adults. Cereb Cortex. 2014 Apr;24(4):1030-6. doi: 10.1093/cercor/bhs385.

    Zimerman M,Hummel FC(2010) Non-invasive brain stimulation: enhancing motor and cognitive functions in healthy old subjects. Front Aging Neurosci. 2010 Dec 1;2:149. doi: 10.3389/fnagi.2010.00149.

    Zimerman M, Nitsch M, Giraux P, Gerloff C, Cohen LG,Hummel FC(2013) Neuroenhancement of the aging brain: restoring skill acquisition in old subjects. Ann Neurol. 2013 Jan;73(1):10-5. doi: 10.1002/ana.23761.

  • Motor learning in healthy aging
    Motor learning testing

    As age-related declines in motor performance and skill acquisition affect healthy older people to pursue normal daily activities, the goal of this project is to get a better understanding of procedural learning in the form of fine motor skills over an intensive training period. A group of very old (>65 years) and a control group of young participants perform a sequential finger tapping task. The training is accompanied with extensive transcranial magnetic stimulation (TMS) protocols to examine intracortical changes.

    In a second study arm, transcranial direct current stimulation (tDCS) is applied sham-controlled in healthy older participants. The aim of tDCS application is to alter membrane potential with the potential to achieve cortical changes after stimulation has ended. In an attempt to optimize motor learning older participants receive stimulation during the task.


    Publications

    Schulz R, Zimerman M, Timmermann J, Wessel MJ, Gerloff C, Hummel FC (2014) White matter integrity of motor connections related to training gains in healthy aging. Neurobiol Aging. 2014 Jun;35(6):1404-11. doi: 10.1016/j.neurobiolaging.2013.11.024.

    Liuzzi G, Hoerniss V, Zimerman M, Gerloff C, Hummel FC (2011) Coordination of uncoupled bimanual movements by strictly timed interhemispheric connectivity. J Neurosci. 2011 Jun 22;31(25):9111-7. doi: 10.1523/JNEUROSCI.0046-11.2011.

    Gerloff C, Andres FG (2002) Bimanual coordination and interhemispheric interaction. Acta Psychol (Amst). 2002 Jun;110(2-3):161-86.

    Andres FG, Mima T, Schulman AE, Dichgans J, Hallett M, Gerloff C (1999) Functional coupling of human cortical sensorimotor areas during bimanual skill acquisition. Brain 122, 855-70.

Neurofibromatosis

  • Xeni NF
    Testing in NF patient

    We investigate how neurofibromatosis (NF) affects motor learning and bimanual coordination. The project targets patients with a gene mutation, leading to tumors along the nervous system. We work in collaboration with Prof. Mautner, who oversees the outpatient clinic for neurofibromatosis at the University Medical Center Hamburg. As we revealed in a selected subgroup of well-functioning individuals, procedural learning seems to be impaired in NF patients, going along with intracortical inhibition. The disease provides the unique opportunity to study a model for increased Gamma-aminobutyric acid (GABA)-mediated inhibition as an underlying mechanism affecting learning via long-term potentiation. Our multimodal study design includes Magnetic Resonance Imaging (MRI),Electroencephalography (EEG), behavioral testing and Transcranial Magnetic Stimulation (TMS) in order to advance the understanding of neurofibromatosis along with neurophysiological changes in terms of inter- and intrahemispheric interactions during uni- and bimanual finger movements.


    Funding

    "Forschungsförderungsfonds der Medizinischen Fakultät”, UKE


    Publications

    Farschtschi S, Park SJ, Sawitzki B, Oh SJ, Kluwe L, Mautner VF, Kurtz A (2016) Effector T cell subclasses associate with tumor burden in neurofibromatosis type 1 patients. Cancer Immunol Immunother. 2016 Sep;65(9):1113-21. doi: 10.1007/s00262-016-1871-0.

    Zimerman M, Wessel MJ, Timmermann JE, Granström S, Gerloff C, Mautner VF, Hummel FC (2015) Impairment of Procedural Learning and Motor Intracortical Inhibition in Neurofibromatosis Type 1 Patients. EBioMedicine. 2015 Sep 1;2(10):1430-7. doi: 10.1016/j.ebiom.2015.08.036.

    Rauen KA1, Huson SM, Burkitt-Wright E, Evans DG, Farschtschi S, Ferner RE, Gutmann DH, Hanemann CO, Kerr B, Legius E, Parada LF, Patton M, Peltonen J, Ratner N, Riccardi VM, van der Vaart T, Vikkula M, Viskochil DH, Zenker M, Upadhyaya M (2015) Recent developments in neurofibromatoses and RASopathies: management, diagnosis and current and future therapeutic avenues. Am J Med Genet A. 2015 Jan;167A(1):1-10. doi: 10.1002/ajmg.a.36793.

    Granström S, Friedrich RE, Langenbruch AK, Augustin M, Mautner VF (2014) Influence of learning disabilities on the tumour predisposition syndrome NF1- survey from adult patients' perspective. Anticancer Res. 2014 Jul;34(7):3675-81.

    Lidzba K, Granström S, Lindenau J, Mautner VF (2012) The adverse influence of attention-deficit disorder with or without hyperactivity on cognition in neurofibromatosis type 1. Dev Med Child Neurol. 2012 Oct;54(10):892-7. doi: 10.1111/j.1469-8749.2012.04377.x.

Publications

  • Leischner H, Flottmann F, Hanning U, Broocks G, Faizy TD, Deb-Chatterji M,
    Bernhardt M, Brekenfeld C, Buhk JH, Gellissen S, Thomalla G, Gerloff C, Fiehler
    J. Reasons for failed endovascular recanalization attempts in stroke patients. J
    Neurointerv Surg. 2018 Nov 24. pii: neurintsurg-2018-014060. doi:
    10.1136/neurintsurg-2018-014060. [Epub ahead of print] PubMed PMID: 30472671.

    Alegiani AC, Dorn F, Herzberg M, Wollenweber FA, Kellert L, Siebert E, Nolte
    CH, von Rennenberg R, Hattingen E, Petzold GC, Bode FJ, Pfeilschifter W, Schäfer
    JH, Wagner M, Röther J, Eckert B, Kraft P, Pham M, Boeckh-Behrens T, Wunderlich
    S, Bernkopf K, Reich A, Wiesmann M, Mpotsaris A, Psychogios M, Liman J, Maier I,
    Berrouschot J, Bormann A, Limmroth V, Spreer J, Petersen M, Krause L, Lowens S,
    Kraemer C, Zweynert S, Lange KS, Thonke S, Kastrup A, Papanagiotou P, Alber B,
    Braun M, Fiehler J, Gerloff C, Dichgans M, Thomalla G. Systematic evaluation of
    stroke thrombectomy in clinical practice: The German Stroke Registry Endovascular
    Treatment. Int J Stroke. 2018 Oct 22:1747493018806199. doi:
    10.1177/1747493018806199. [Epub ahead of print] PubMed PMID: 30346260.

    Diener HC, Gerloff C, Thaler DE, Wöhrle J. Closure of Patent Foramen Ovale and
    Cryptogenic Stroke: Unresolved Issues. Curr Neurol Neurosci Rep. 2018 Oct
    17;18(12):92. doi: 10.1007/s11910-018-0910-y. Review. PubMed PMID: 30328522.

    Nickel A, Cheng B, Pinnschmidt H, Arpa E, Ganos C, Gerloff C, Thomalla G.
    Clinical Outcome of Isolated Cerebellar Stroke-A Prospective Observational Study.
    Front Neurol. 2018 Jul 17;9:580. doi: 10.3389/fneur.2018.00580. eCollection 2018.
    PubMed PMID: 30065696; PubMed Central PMCID: PMC6056646.

    Choe CU, Hidding U, Schaper M, Gulberti A, Köppen J, Buhmann C, Gerloff C,
    Moll CKE, Hamel W, Pötter-Nerger M. Thalamic short pulse stimulation diminishes
    adverse effects in essential tremor patients. Neurology. 2018 Aug
    21;91(8):e704-e713. doi: 10.1212/WNL.0000000000006033. Epub 2018 Jul 25. PubMed
    PMID: 30045955.

    Bönstrup M, Schulz R, Schön G, Cheng B, Feldheim J, Thomalla G, Gerloff C.
    Parietofrontal network upregulation after motor stroke. Neuroimage Clin. 2018 Mar
    7;18:720-729. doi: 10.1016/j.nicl.2018.03.006. eCollection 2018. PubMed PMID:
    29876261; PubMed Central PMCID: PMC5987870.

    Galinovic I, Dicken V, Heitz J, Klein J, Puig J, Guibernau J, Kemmling A,
    Gellissen S, Villringer K, Neeb L, Gregori J, Weiler F, Pedraza S, Thomalla G,
    Fiehler J, Gerloff C, Fiebach JB; WAKE-UP Investigators. Homogeneous application
    of imaging criteria in a multicenter trial supported by investigator training: A
    report from the WAKE-UP study. Eur J Radiol. 2018 Jul;104:115-119. doi:
    10.1016/j.ejrad.2018.05.011. Epub 2018 May 15. PubMed PMID: 29857856.

    Thomalla G, Simonsen CZ, Boutitie F, Andersen G, Berthezene Y, Cheng B,
    Cheripelli B, Cho TH, Fazekas F, Fiehler J, Ford I, Galinovic I, Gellissen S,
    Golsari A, Gregori J, Günther M, Guibernau J, Häusler KG, Hennerici M, Kemmling
    A, Marstrand J, Modrau B, Neeb L, Perez de la Ossa N, Puig J, Ringleb P, Roy P,
    Scheel E, Schonewille W, Serena J, Sunaert S, Villringer K, Wouters A, Thijs V,
    Ebinger M, Endres M, Fiebach JB, Lemmens R, Muir KW, Nighoghossian N, Pedraza S,
    Gerloff C; WAKE-UP Investigators. MRI-Guided Thrombolysis for Stroke with Unknown
    Time of Onset. N Engl J Med. 2018 Aug 16;379(7):611-622. doi:
    10.1056/NEJMoa1804355. Epub 2018 May 16. PubMed PMID: 29766770.

    Schröder J, Cheng B, Malherbe C, Ebinger M, Köhrmann M, Wu O, Kang DW,
    Liebeskind DS, Tourdias T, Singer OC, Campbell B, Luby M, Warach S, Fiehler J,
    Kemmling A, Fiebach JB, Gerloff C, Thomalla G. Impact of Lesion Load Thresholds
    on Alberta Stroke Program Early Computed Tomographic Score in Diffusion-Weighted
    Imaging. Front Neurol. 2018 Apr 23;9:273. doi: 10.3389/fneur.2018.00273.
    eCollection 2018. PubMed PMID: 29740391; PubMed Central PMCID: PMC5926541.

    Haeusler KG, Gröschel K, Köhrmann M, Anker SD, Brachmann J, Böhm M, Diener
    HC, Doehner W, Endres M, Gerloff C, Huttner HB, Kaps M, Kirchhof P, Nabavi DG,
    Nolte CH, Pfeilschifter W, Pieske B, Poli S, Schäbitz WR, Thomalla G, Veltkamp R,
    Steiner T, Laufs U, Röther J, Wachter R, Schnabel R. Expert opinion paper on
    atrial fibrillation detection after ischemic stroke. Clin Res Cardiol. 2018
    Oct;107(10):871-880. doi: 10.1007/s00392-018-1256-9. Epub 2018 Apr 27. Review.
    PubMed PMID: 29704214.

    Löwe B, Gerloff C. Functional Somatic Symptoms Across Cultures: Perceptual
    and Health Care Issues. Psychosom Med. 2018 Jun;80(5):412-415. doi:
    10.1097/PSY.0000000000000594. PubMed PMID: 29677034.

    Meyer-Hamme G, Friedemann T, Greten HJ, Plaetke R, Gerloff C, Schroeder S.
    ACUDIN - ACUpuncture and laser acupuncture for treatment of DIabetic peripheral
    Neuropathy: a randomized, placebo-controlled, partially double-blinded trial. BMC
    Neurol. 2018 Apr 13;18(1):40. doi: 10.1186/s12883-018-1037-0. PubMed PMID:
    29653569; PubMed Central PMCID: PMC5898043.

    Sharott A, Gulberti A, Hamel W, Köppen JA, Münchau A, Buhmann C,
    Pötter-Nerger M, Westphal M, Gerloff C, Moll CKE, Engel AK. Spatio-temporal
    dynamics of cortical drive to human subthalamic nucleus neurons in Parkinson's
    disease. Neurobiol Dis. 2018 Apr;112:49-62. doi: 10.1016/j.nbd.2018.01.001. Epub
    2018 Jan 4. PubMed PMID: 29307661; PubMed Central PMCID: PMC5821899.

    Thomalla G, Boutitie F, Fiebach JB, Simonsen CZ, Pedraza S, Lemmens R,
    Nighoghossian N, Roy P, Muir KW, Ebinger M, Ford I, Cheng B, Galinovic I, Cho TH,
    Puig J, Thijs V, Endres M, Fiehler J, Gerloff C. Clinical characteristics of
    unknown symptom onset stroke patients with and without diffusion-weighted imaging
    and fluid-attenuated inversion recovery mismatch. Int J Stroke. 2018
    Jan;13(1):66-73. doi: 10.1177/1747493017706245. Epub 2017 Apr 20. PubMed PMID:
    28425349.

  • Fründt O, Schulz R, Schöttle D, Cheng B, Thomalla G, Braaß H, Ganos C, David N, Peiker I, Engel AK, Bäumer T, Münchau A. White Matter Microstructure of the Human Mirror Neuron System is Related to Symptom Severity in Adults with Autism. J Autism Dev Disord. 2017 Oct 12. (Epub)

    Schulz R, Frey BM, Koch P, Zimerman M, Bönstrup M, Feldheim J, Timmermann JE, Schön G, Cheng B, Thomalla G, Gerloff C, Hummel FC. Cortico-Cerebellar Structural Connectivity Is Related to Residual Motor Output in Chronic Stroke. Cereb Cortex. 2017 Jan 1;27(1):635-645.

  • Finger H, Bönstrup M, Cheng B, Messé A, Hilgetag C, Thomalla G, Gerloff C, König P. Modeling of Large-Scale Functional Brain Networks Based on Structural Connectivity from DTI: Comparison with EEG Derived Phase Coupling Networks and Evaluation of Alternative Methods along the Modeling Path. PLoS Comput Biol. 2016 Aug 9;12(8):e1005025.

    Backhaus W, Braass H, Renné T, Gerloff C, Hummel FC. Motor Performance Is not Enhanced by Daytime Naps in Older Adults. Front Aging Neurosci. 2016 May 31;8:125.

    Backhaus W, Braaß H, Renné T, Krüger C, Gerloff C, Hummel FC. Daytime sleep has no effect on the time course of motor sequence and visuomotor adaptation learning. Neurobiol Learn Mem. 2016 May;131:147-54.

    Schulz R, Buchholz A, Frey BM, Bönstrup M, Cheng B, Thomalla G, Hummel FC, Gerloff C. Enhanced Effective Connectivity Between Primary Motor Cortex and Intraparietal Sulcus in Well-Recovered Stroke Patients. Stroke. 2016 Feb;47(2):482-9.

    Bönstrup M, Schulz R, Feldheim J, Hummel FC, Gerloff C. Dynamic causal modelling of EEG and fMRI to characterize network architectures in a simple motor task. Neuroimage. 2016 Jan 1;124(Pt A):498-508.

    Zimerman M, Wessel MJ, Timmermann JE, Granström S, Gerloff C, Mautner VF, Hummel FC. Impairment of Procedural Learning and Motor Intracortical Inhibition in Neurofibromatosis Type 1 Patients. EBioMedicine. 2015 Sep 1;2(10):1430-7.

    Wessel MJ, Zimerman M, Timmermann JE, Heise KF, Gerloff C, Hummel FC. Enhancing Consolidation of a New Temporal Motor Skill by Cerebellar Noninvasive Stimulation. Cereb Cortex. 2016 Apr;26(4):1660-7.

  • Meyer S*, Keßner SS*, Cheng B, Bönstrup M, Schulz R, Hummel FC, De Bruyn N, Peeters A, Van Pesch V, Duprez T, Sunaert S, Schrooten M, Feys H, Gerloff C, Thomalla G, Thijs V, Verheyden G. Voxel-based lesion-symptom mapping of stroke lesions underlying somatosensory deficits. Neuroimage Clin. 2015 Dec 11;10:257-66.

    Bönstrup M, Schulz R, Cheng B, Feldheim J, Zimerman M, Thomalla G, Hummel FC, Gerloff C. Evolution of brain activation after stroke in a constant-effort versus constant-output motor task. Restor Neurol Neurosci. 2015;33(6):845-64.

    Bönstrup M, Hagemann J, Gerloff C, Sauseng P, Hummel FC. Alpha oscillatory correlates of motor inhibition in the aged brain. Front Aging Neurosci. 2015 Oct 13;7:193.

    Schulz R, Koch P, Zimerman M, Wessel M, Bönstrup M, Thomalla G, Cheng B, Gerloff C, Hummel FC. Parietofrontal motor pathways and their association with motor function after stroke. Brain. 2015 Jul;138(Pt 7):1949-60.

    Cheng B, Schulz R, Bönstrup M, Hummel FC, Sedlacik J, Fiehler J, Gerloff C, Thomalla G. Structural plasticity of remote cortical brain regions is determined by connectivity to the primary lesion in subcortical stroke. J Cereb Blood Flow Metab. 2015 Sep;35(9):1507-14.

    Schulz R, Wessel MJ, Zimerman M, Timmermann JE, Gerloff C, Hummel FC. White Matter Integrity of Specific Dentato-Thalamo-Cortical Pathways is Associated with Learning Gains in Precise Movement Timing. Cereb Cortex. 2015 Jul;25(7):1707-14.

    Backhaus W, Kempe S, Hummel FC. The effect of sleep on motor learning in the aging and stroke population - a systematic review. Restor Neurol Neurosci. 2015;34(1):153-64.

    Freundlieb N, Backhaus W, Brüggemann N, Gerloff C, Klein C, Pinnschmidt HO, Hummel FC. Differential effects of BDNF val(66)met in repetitive associative learning paradigms. Neurobiol Learn Mem. 2015 Sep;123:11-7.

    Krawinkel L; Engel AK; Hummel FC. Modulating pathological oscillations by rhythmic non-invasive brain stimulation - a therapeutic concept? Frontiers in Systems Neuroscience 2015 Mar 17;9:33.

    Schulz R, Braaß H, Liuzzi GP, Hörniß V, Lechner P, Gerloff C, Hummel FC. White matter integrity of premotor-motor connections is associated with motor impairment in chronic stroke patients. NeuroImage Clin 2015 Nov 18;7:82-6.

  • Freundlieb N, Philipp S, Drabik A, Gerloff C, Forkert N, Hummel FC (2014) Ipsilesional motor area size correlates with functional recovery after stroke: Results from a 6-month follow-up longitudinal TMS motor mapping study. Restorative Neurology and Neuroscience Dec 12.

    Quandt F & Hummel FC (2014) The influence of functional electrical stimulation on hand motor recovery in stroke patients: A review. Experimental & Translational Stroke Medicine Aug 21;6:9.

    Hamann J, Dayan E, Hummel FC & Cohen LG (2014) Baseline frontostriatal-limbic connectivity predicts reward-based memory formation. Human Brain Mapping Dec;35(12):5921-31.

    Heise K, Niehoff M, Feldheim J, Liuzzi G, Gerloff C, Hummel FC (2014) Differential effects of anodal transcranial direct current stimulation in healthy adults of younger and older age: inhibitory neurotransmission and behavior. Frontiers in Ageing Neuroscience. 6:146.

    Berger B, Minarik T, Liuzzi GP, Hummel FC, Sauseng P (2014) EEG oscillatory phase-dependent markers for cortico-spinal excitability in the resting brain. BioMed Research International 2014:936096.

    Lefaucheur J-P, André-Obadia N, Antal A, Ayache SS, Baeken C, Benninger DH, Cantelloi RM, Cincotta M, De Carvalho M, De Ridder D, Devanne H, Di Lazzaro V, Filipovic SR, Hummel FC, Jääskeläinen SK, Kimiskidis VK, Koch G, Langguth G, Nyffeler T, Oliviero A, Padberg F, Pouletz E, Rossi S, Rossini PM, Rothwell JC, Schönfeldt-Lecuona C, Siebner HR, Slotema SW, Stagg CJ, Valls-Sole J, Ziemann U, Paulus W, Garcia-Larrea L (2014) Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS). Clinical Neurophysiology Jun 5. pii: S1388-2457(14)00296-X.

    Boenstrup M, Feldheim J, Heise K, Gerloff C, Hummel FC (2014) The control of complex finger movements by directional information flow between mesial frontocentral areas and the primary motor cortex. European J Neuroscience Sep;40(6):2888-97.

    Hummel FC (2014) Kombination von TMS und MRT zum Verständnis neurologischer Erkrankungen [Combination of TMS and MRT to understand neurological diseases.] Nervenarzt. May 23. [Epub ahead of print].

    Birbaumer N, Hummel FC. (2014) Habit learning and brain-machine interfaces (BMI): a tribute to Valentino Braitenberg's "Vehicles". Biol Cybern. [Epub ahead of print].

    Schulz R, Wessel MJ, Zimerman M, Timmermann JE, Gerloff C, Hummel FC (2014) White Matter Integrity of Specific Dentato-Thalamo-Cortical Pathways is Associated with Learning Gains in Precise Movement Timing. Cereb Cortex. [Epub ahead of print].

    Schulz R, Zimerman M, Timmermann JE, Wessel MJ, Gerloff C, Hummel FC (2014) White matter integrity of motor connections related to training gains in healthy aging. Neurobiol Aging.35(6):1404-11.

    Cheng B, Braass H, Ganos C, Treszl A, Biermann-Ruben K, Hummel FC, Müller-Vahl K, Schnitzler A, Gerloff C, Münchau A, Thomalla G (2014) Altered intrahemispheric structural connectivity in Gilles de la Tourette syndrome. Neuroimage Clin.4:174-81.

    Liuzzi G, Hörniß V, Lechner P, Hoppe J, Heise K, Zimerman M, Gerloff C, Hummel FC (2014) Development of movement-related intracortical inhibition in acute to chronic subcortical stroke. Neurology. Jan 21;82(3):198-205

    Thomalla G, Jonas M, Bäumer T, Siebner HR, Biermann-Ruben K, Ganos C, Orth M, Hummel FC, Gerloff C, Müller-Vahl K, Schnitzler A, Münchau A (2014) Costs of control: decreased motor cortex engagement during a Go/NoGo task in Tourette's syndrome. Brain. Jan;137(Pt 1):122-36.

    Zimerman M, Heise KF, Gerloff C, Cohen LG, Hummel FC (2014) Disrupting the ipsilateral motor cortex interferes with training of a complex motor task in older adults.Cereb Cortex. Apr;24(4):1030-6.

  • Zimerman M, Nitsch M, Giraux P, Gerloff C, Cohen LG, Hummel FC.(2013) Neuroenhancement of the aging brain: restoring skill acquisition in old subjects. Ann Neurol. Jan;73(1):10-5

    Wessel M, Zimerman M, Timmermann JE, Hummel FC. (2013) Eyelid myokymia in an older subject after repetitive sessions of anodal transcranial direct current stimulation.Brain Stimul. May;6(3):463-5.

    Heise KF, Zimerman M, Hoppe J, Gerloff C, Wegscheider K, Hummel FC (2013) The aging motor system as a model for plastic changes of GABA-mediated intracortical inhibition and their behavioral relevance. J Neurosci. May 22;33(21):9039-49.

    Sauseng P, Gerloff C, Hummel FC.(2013) Two brakes are better than one: the neural bases of inhibitory control of motor memory traces. Neuroimage. Jan 15;65:52-8

  • Jaenecke, T.; Heise, K.-F.; Hummel, F.C. Orthesengestütztes Eigentraining im häuslichen Umfeld führt zu motorisch-funktioneller Verbesserung bei einem Patienten nach Schlaganfall. Physioscience

    Freundlieb, N., Phillip, S.; Schneider, S.; Brüggemann, N.; Klein, C.; Gerloff, C.; Hummel, F.C. No association of the BDNF val66met polymorphism with short-term associative vocabulary and implicit motor learning. Plos One 7(11):e48327

    Sauseng, P., Gerloff, C., Hummel, F.C. Cognitive control of memory traces: decoupling of interregional alpha activity during sustained inhibition of a motor memory trace. Neuroimage Sep 29;65C:52-58

    Hummel, F.C. & Gerloff, C. (2012) Leitthema: Transkranielle Hirnstimulation nach Schlaganfall, Nervenarzt Aug;83(8):957-65

    Schulz, R., Park, C.,Boudrias, M.-H., Gerloff, C., Hummel, F.C.*, Ward, N.* (2012) Corticospinal tracts originating in primary and secondary motor areas predict grip-strength in chronic stroke patients Stroke Aug;43(8):2248-51. *both authors contributed equally

    Schulz R, Gerloff C, Hummel FC (2012) Non-invasive brain stimulation in neurological diseases, Neuropharmacology Jan;64(1):579-87

    Zimerman, M., Heise, K., Hoppe, J., Cohen, L.G., Gerloff, C., Hummel, F.C. (2012) Modulation of Training by tDCS to the Intact Motor Cortex Enhances Motor Skill Acquisition of the Paretic Hand Stroke Aug;43(8):2185-91.

    Freundlieb, N., Riddder, V., Dobel, C., Enriquez-Geppert, S., Baumgärtner, A.; Zwitserlood, P., Gerloff, C., Hummel, F.C.*; Liuzzi, G.P.* (2012) Associative vocabulary learning: Development and testing of two paradigms for the (re-) acquisition of action- and object-related words Plos One 7(6):e37033. *both authors contributed equally

    Sitaram, R., Veit, R., Steven, B., Caria, A., Gerloff, C., Birbaumer, N., Hummel, F.C. (2012) Acquired control of ventral premotor cortex activity by feedback training: An exploratory real-time fMRI and TMS study. Neurorehabilitation and Neural Repair Mar-Apr;26(3):256-65

  • Sauseng P, Feldheim JF, Freunberger R, Hummel FC.(2011) Right Prefrontal TMS Disrupts Interregional Anticipatory EEG Alpha Activity during Shifting of Visuospatial Attention. Front Psychol. 2011;2:241

    Ganos, C. & Hummel, F.C. (2011) My urge, my tic - a missing link between urges and tic inhibition Cognitive Neuroscience

    Liuzzi, G.P., Hörniss, V., Zimerman, M., Gerloff, C., Hummel, F.C. (2011) Coordination of uncoupled bimanual movements by strictly timed interhemispheric connectivity Journal of Neuroscience Jun 22;31(25):9111-9117

  • Zimerman, M., Hummel, F.C. (2010) Non-invasive brain stimulation: enhancing declined motor and cognitive functions in healthy old subjects. Frontiers in Ageing Neuroscience Dec 1;2:149

    Baumer, T.; Thomalla, G.; Kroeger, J.;Jonas, M.; Gerloff, C.; Hummel, F. C.; Muller-Vahl, K.; Schnitzler, A.; Siebner, H. R.; Orth, M.; Munchau, A. (2010) Interhemispheric motor networks are abnormal in patients with Gilles de la Tourette syndrome. Movement Disorders Oct 19.

    Liuzzi, G.P., Freundlieb, N., Riddder, V., Hoppe, J., Heise, K., Zimerman, M., Dobel, C., Enriquez-Geppert, S., Gerloff, C., Zwitserlood, P., Hummel, F.C. (2010) The Involvement of the Left Motor Cortex in Learning of a Novel Action Word Lexicon. Current Biology 2010 Oct 12;20(19):1745-51. Epub 2010 Sep 30.

    Heise, K., Steven, B., Liuzzi, G.P., Thomalla G, Jonas M, Müller-Vahl K, Sauseng, P., Münchau A. Gerloff, C., Hummel, F.C. (2010) Altered modulation of intracortical excitability during movement preparation in Gilles de la Tourette. Brain 2010 133: 580-590, Brain Advance Access published on December 11, 2009

    Liuzzi, G.P., Hörniß, V., Hoppe, J., Heise, K., Zimerman, M., Gerloff, C., Hummel, F.C. (2010) Distinct temporospatial interhemispheric interactions in the human primary and premotor cortex during movement preparation. Cerebral Cortex Jun;20(6):1323-31. Epub 2009 Nov 11.

    Duque, J., Davare, M., Delaunay, L., Jacob, B., Saur, R., Hummel, F., Hermoye, L., Rossion, B., Olivier, E. (2010). Monitoring coordination during bimanual movements;where is the mastermind?. J. Cogn Neuroscience Mar;22(3):526-42.

    Hummel FC, Heise K, Celnik P, Floel A, Gerloff C, Cohen LG (2010) Facilitating skilled right hand motor function in older subjects by anodal polarization over the left primary motor cortex. Neurobiol Aging, 2010. 31(12): p. 2160-8.

  • Sauseng P, Klimesch W, Heise KF, Gruber WR, Holz E, Karim AA, Glennon M, Gerloff C, Birbaumer N, Hummel FC. (2009): Brain oscillatory substrates of visual short-term memory capacity. Curr Biol. 2009 Nov 17;19(21):1846-52.

    Choe, C., Lewerenz, J., Fischer, G., Uliasz, T.F., Espey, M.G., Hummel, F.C., King, B., Schwedhelm, E., Böger, R.H., Gerloff, C., Hewett, S.J., Magnus, T., Donzelli, S. (2009): HNO exacerbates ischemic cerebral injury and oxidative neurotoxicity. Journal of Neurochemistry Jul 8.

    Hummel, F.C. (2009). Transkranielle Stimulation in der Neurorehabilitation (Transcranial Stimulation in Neurological Rehabilitation). Klin Neurophys; 40: 134-141

    Duque, J., Davare, M., Delaunay, L., Jacob, B., Saur, R., Hummel, F., Hermoye, L., Rossion, B., Olivier, E. (2009). Monitoring coordination during bimanual movements;where is the mastermind?. J. Cogn Neuroscience Mar 23.

    Färber, M., Hummel, F., Gerloff, C., Handels, H. (2009). Virtual Reality Simulator for the Training of Lumbar Punctures. Methods Inf Med. May 15;48(4).

    Hummel, F., Heise, K., Floel, A., Celnik, P., Gerloff, C., Cohen, L.G. (2009): Improvement of skilled motor functions in healthy elderly subjects by cortical stimulation Neurobiology of Aging Feb 5.

    Hummel, F., Steven, B., Hoppe, J., Heise, K., Thomalla, G., Cohen, L.G., Gerloff, C., (2009) Deficient intracortical inhibition (SICI) during movement preparation after chronic stroke, Neurology 72(20):1766-72.

    Thomalla G, Siebner HR, Jonas M, Bäumer T, Biermann-Ruben K, Hummel F, Gerloff C, Müller-Vahl K, Schnitzler A, Orth M, Münchau A. (2009) Structural changes in somatosensory pathways correlate with tic severity in Gilles de la Tourette syndrome. Brain 132(Pt 3):765-7

    Sauseng, P., Klimesch, W., Gerloff, C., Hummel, F. (2009): Spontaneous locally restricted EEG alpha activity determines cortical excitability in the motor cortex. Neuropsychologica 47(1):284-8. Epub 2008 Aug 3.

    Ruiz, M.H., Senghaas, P., Grossbach, M., Jabusch, H.-C., Bangert, M., Hummel, F.C., Gerloff, C., Altenmüller, E. (2009) ,Defective inhibition and inter-regional phase synchronization in pianists with musician's dystonia (MD): an EEG study. Human Brain Mapping Aug;30(8):2689-700. Dec 31.

  • Jansen, A*, Liuzzi G*, Deppe M, Kanowski M, Ölschläger C, Albers JM, Knecht S (in press) Structural correlates of functional language dominance: A voxel based morphometry study. Journal of Neuroimaging (*shared first authors)

    Liuzzi G., Ellger T., Floel A., Breitenstein C., Jansen A., Knecht S. (2008): Walking the Talk - Speech Activates the Leg Motor Cortex. Neuropsychologia 46(11):2824-30

    Sauseng, P., Klimesch, W., Gerloff, C., Hummel, F. (2008): Spontaneous locally restricted EEG alpha activity determines cortical excitability in the motor cortex. Neuropsychologica 2008 Aug 3

    Reis, J., Robertson, E., Marshall, L., Gerloff, C., Wassermann, E., Pascual-Leone, A., Krakauer, J., Hummel, F., Celnik, P., Classen, J., Floel, A., Ziemann, U., Paulus, W., Siebner, H., Rothwell, J., Born, J., Cohen L.G. (2008): Controversy: "Can tDCS and TMS enhance motor learning and memory formation?" Brain Stimulation. 1(4):363-369

    Nitsche, M.A, Cohen, L.G., Wassermann, E., Priori, A., Lang, N., Antal, A., Paulus, W., Hummel, F., Boggio, P.S., Fregni, F., Pascual-Leone, A. (2008). Transcranial direct current stimulation: state of the art 2008. Brain Stimulation. 1(3):206-223

    Hummel, F., Celnik, P., Pascual-Leone, A. Fregni, F., Byblow, W.D., Butefisch, C., Rothwell, J., Cohen, L.G., Gerloff, C. (2008) Controversy: Noninvasive and invasive cortical stimulation show efficacy in treating stroke patients. Brain Stimulation 1(4):370-382

    Floel, A., Hummel, F., Duque, J., Knecht, S., Cohen, L.G. (2008) Influence of Somatosensory Input on Interhemispheric Interactions in Patients With Chronic Stroke. Neurorehabil Neural Repair. Jul 21.

    Färber, M., Hoeborn, E., Dalek, D., Hummel, F., Gerloff, C., Bohn, C.A., Handels, H. (2008). Training and evaluation of lumbar punctures in a VR-environment using a 6DOF haptic device. Stud Health Technol Inform;132:112-4.

    Plewnia, C., Rilk, A., Soekadar, S., Huber, H., Sauseng, P., Hummel, F., Gerloff, C. (2008) Enhancement of long-range EEG coherence by synchronous bifocal transcranial magnetic stimulation. Eur J Neurosci Mar;27(6):1577-83.

    Duque J, Mazzocchio R, Stefan K, Hummel F, Olivier E, Cohen LG (2008) Memory Formation in the Motor Cortex Ipsilateral to a Training Hand Cereb Cortex. Jun;18(6):1395-406.

    Floel, A., Hummel, F., Duque, J., Knecht, S., Cohen, L.G. (2008) Influence of Somatosensory Input on Interhemispheric Interactions in Patients With Chronic Stroke. Neurorehabil Neural Repair. 22(5):477-85. Epub 2008 Jul 21.

  • Celnik, P., Hummel, F., Harris-Love, M., Wolk, R., Cohen, L.G. (2007): Somatosensory Stimulation Enhances Learning of Functional Tasks after Stroke. Arch Phys Med Rehabil. Nov;88(11):1369-76.

    Sauseng, P., Hoppe, J., Klimesch, W., Gerloff, C., Hummel, F. (2007): Dissociation of sustained attention from central executive functions: Local activity and interregional connectivity in the theta range. Eur J Neurosci. 25(2):587-93.

    Duque, J., Murase, N., Celnik, P., Hummel, F., Harris-Love, M., Mazzocchio, R., Olivier, E., Cohen, L.G. (2007): Intermanual differences in movement-related interhemispheric inhibition. J Cogn Neurosci. 19(2):204-13.

  • Hummel, F., Voller, B., Celnik, P., Floel, A., Giraux, P., Gerloff,C., Cohen, L.G. (2006): Effects of cortical stimulation on primary motor cortex function after stroke. BMC Neuroscience Nov 3;7:73.

    Hummel, F. (2006): Nicht invasive Hinrstimulation. Eine innovative Strategie zur Verbesserung der Erholung nach Schlaganfall. Neurodate Nov 20 (158), 28-33.

    Hummel, F. & Gerloff, C. (2006). Chapter 15 Interregional long-range and short-range synchrony: a basis for complex sensorimotor processing. Prog Brain Res 159:223-36.

    Hummel, F. & Cohen, L.G. (2006): Noninvasive brainstimulation: a novel strategy to enhance functional recovery? Lancet Neurology Aug;5(8):708-712.

    Gandiga, P*., Hummel, F*., Cohen, L.G. (2006): Transcranial DC Stimulation (tDCS): a tool for double-blind sham-controlled clinical studies in brain stimulation. Clinical Neurophysiology Apr;117(4):845-50. Epub 2006 Jan 19. *both authors contributed equally

    Celnik, P., Stefan, K., Hummel, F., Duque, J., Cohen, L.G. (2006): Encoding a motor memory in the elder by action observation. NeuroImage 15;29(2):677-684. Epub 2005 Aug 24.

  • Hummel, F. & Cohen, L.G. (2005): Drivers of brain plasticity. Current Opinion in Neurology 18(6):667-674.

    Duque, J., Hummel, F., Murase, N., Celnik, P, Mazzocchio, R., Cohen, L.G. (2005) Transcallosal inhibition in chronic subcortical stroke. NeuroImage 28 (4): 940-946, Epub 2005 Aug 3.

    Floel, A., Hummel, F., Breitenstein, C., Knecht, S., Cohen, L.G. (2005) Dopaminergic effects on encoding of a motor memory in chronic stroke. Neurology 65(3), 472-474.

    Floel, A., Breitenstein, C., Hummel, F., Celnik, P., Gingert, C., Sawaki, L., Knecht, S., Cohen, L.G. (2005) Dopaminergic influence on formation of a motor memory. Ann Neurol 58, 121-130.

    Hummel, F. & Gerloff, C. (2005): Larger interregional synchrony predicts greater behavioral success in a complex sensory integration task in humans. Cereb Cortex May;15(5):670-8. Epub 2004 Sep 1.

    Hummel, F. & Cohen, L.G. (2005): Improvement of motor function with noninvasive cortical stimulation in a patient with chronic stroke. Neurorehabilitation and Neural Repair Mar;19(1):14-9.

    Hummel, F., Celnik, P., Giraux, P., Floel, A., Wu, W.-H., Gerloff, C., Cohen, L.G. (2005): Effects of noninvasive cortical stimulation on skilled motor function in chronic stroke. Brain Mar;128(Pt 3):490-9. Epub 2005 Jan 5.

  • Hummel, F., Saur, R., Lasogga, S., Plewnia, C., Erb, M., Wildgruber, D., Grodd, W., Gerloff, C. (2004): To act or not to act. Neural correlates of executive control of learned motor behavior. NeuroImage 23(4), 1391-1401.

    Hummel, F., Gerloff, C. & Cohen, L.G. (2004): Cross-modal plasticity in sighted and blind individuals. Cognitive Processing 5, 152-158.

    Fridman, E., Hanakawa, T., Chung, M., Hummel, F., Leiguarda, R., Cohen, L.G. (2004): Reorganization of the human ipsilesional premotor cortex after stroke. Brain 127, 747-58.

    Rau, C., Hummel, F., Gerloff, C. (2004). Cortical involvement in the generation of 'involuntary' movements in restless-legs syndrome. Neurology, 23, 62(6):998-1000.

  • Gerloff, C. & Hummel, F. (2003): Inhibitory control of acquired motor programs in the human brain. Suppl Clin Neurophysiol 56:170-4.

    Rau, C., Plewnia, C., Hummel, F., Gerloff, C. (2003): Event-related desynchronization and excitability of the ipsilateral motor cortex during simple self-paced finger movements. Clinical Neurophysiology 114, 1819-1826.

    Hummel, F., Kirsammer, R., Gerloff, C. (2003): Ipsilateral cortical activation during finger sequences of increasing complexity: representation of movement difficulty or memory load? Clinical Neurophysiology 114, 605-613.

  • Hummel, F., Andres, F., Altenmüller, E., Dichgans, J., Gerloff, C. (2002): Inhibitory control of acquired motor programs in the human brain. Brain 125, 404-420.

  • Pulvermuller, F., Harle, M., Hummel, F. (2001): Walking or Talking? : Behavioral and Neurophysiological Correlates of Action Verb Processing. Brain Lang 78, 143-68.

    Pulvermuller, F., Harle, M., Hummel, F. (2000): Neurophysiological distinction of verb categories. Neuroreport 11, 2789-93.

  • Zimerman, M. & Hummel, F.C. & Celnik, P. (2014) Chapter 12: Brain Stimulation and its Role in Neurological Diseases (page 333-370). The Stimulated Brain - Cognitive Enhancement using non-invasive brain stimulation. Edited by R.C.Kadosh. Academic Press

    Hummel, F. (in press). Hirnstimulation in der Neurorehabilitation (Kapitel. 6) in Evidenzbasierte Therapie in der Neurorehabilitation.

    Floel, A., Hummel, F. & Gerloff, C. (2008). Kapitel VIII Modulation von Hirnfunktionen - Therapeutische Ansätze. VIII 56 Schlaganfall. In Transkranielle Magnetstimulation. Edited by U. Ziemann, H.R. Siebner.

    Hummel, F. & Cohen, L.G. (2008). Brain stimulation in neurorehabilitation. In Oxford Handbook of Transcranial Stimulation. Section VI. Therapeutic Applications of TMS. Edited by Sarah H. Lisanby.

    Hummel, F. & Steinbach, J. (2007). H 9. Zerebrale Missbildungen. In Therapie und Verlauf neurologischer Erkrankungen (5. Auflage). Edited by T. Brandt, J. Dichgans & H. Diener.

    Gerloff, C. & Hummel, F. (2006). Role of inhibition in motor control of finger functions. In Music, Motor Control and the Brain. Edited by E. Altenmueller, J. Kesselring, M. Wiesendanger.

    Hummel, F., Gerloff, C., Cohen, L.G. (2005). Modulation of cortical function and plasticity in the human brain. In Neural plasticity in adult somatic sensory-motor systems. Topic 3: Motor system plasticity due to experience or brain damage. Edited by Ford Ebner.