Liver X receptor unlinks intestinal regeneration and tumorigenesis
Das S, Parigi S, Luo X, Fransson J, Kern B, Okhovat A, Diaz O, Sorini C, Czarnewski P, Webb A, Morales R, Lebon S, Monasterio G, Castillo F, Tripathi K, He N, Pelczar P, Schaltenberg N, De la Fuente M, López-Köstner F, Nylén S, Larsen H, Kuiper R, Antonson P, Hermoso M, Huber S, Biton M, Scharaw S, Gustafsson J, Katajisto P, Villablanca E
NATURE. 2025;637(8048):1198-1206.

Podcasts zur Psychoedukation bei Reizdarmsyndrom: Eine mixed methods-Analyse
Gerhold P, Löwe B, Huber S, Weigel A
Z GASTROENTEROL. 2025.

Testosterone affects female CD4+ T cells in healthy individuals and autoimmune liver diseases
Henze L, Will N, Lee D, Haas V, Casar C, Meyer J, Stein S, Mangler F, Steinmann S, Poch T, Krause J, Fuss J, Schröder J, Kulle A, Holterhus P, Bonn S, Altfeld M, Huber S, Lohse A, Schwinge D, Schramm C
JCI INSIGHT. 2025;10(8):e184544.

PSC and colitis: A complex relationship
Horst L, Kempski J, Walmsley M, Huber S, Schramm C
HEPATOLOGY. 2025 [Epub ahead of print].

Recompensation of Liver Cirrhosis by TIPS Reduces Epithelial Cell Death Markers, Translating Into Improved Clinical Outcome
Piecha F, Jahn B, Köntopf J, Koop A, Ozga A, Al-Jawazneh A, Harberts A, Riedel C, Buggisch P, Benten D, Hübener P, Adam G, Huber S, Lohse A, Bannas P, Kluwe J
LIVER INT. 2025;45(4):e16156.

Metabolomic liquid biopsy dynamics predict early-stage HCC and actionable candidates of human hepatocarcinogenesis
Schulze K, Rose T, Adlung L, Peschka M, Pagani F, Gorgulho J, Fründt T, Labgaa I, Haber P, Zimpel C, Castven D, Weinmann A, Garzia-Lezana T, Waldmann M, Renné T, Voß H, Moritz M, Orlikowski D, Schlüter H, Baumbach J, Schwartz M, Lohse A, Huber S, Sangro B, Macias R, Izquierdo-Sanchez L, Banales J, Wege H, Marquardt J, Villanueva A, Pauling J, von Felden J
JHEP REP. 2025;7(5):101340.

Reply to: Challenges in interpreting the role of gentamicin in treatment of invasive listeriosis: immortal timebias and confounding
Sutter J, Kocheise L, Kempski J, Christner M, Wichmann D, Pinnschmidt H, Schmiedel S, Lohse A, Huber S, Brehm T
INFECTION. 2025;53(3):1249-1250.

Author Correction: Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer
Tintelnot J, Xu Y, Lesker T, Schönlein M, Konczalla L, Giannou A, Pelczar P, Kylies D, Puelles V, Bielecka A, Peschka M, Cortesi F, Riecken K, Jung M, Amend L, Bröring T, Trajkovic-Arsic M, Siveke J, Renné T, Zhang D, Boeck S, Strowig T, Uzunoglu F, Güngör C, Stein A, Izbicki J, Bokemeyer C, Sinn M, Kimmelman A, Huber S, Gagliani N
NATURE. 2025;641(8065):E12-E13.

Protective function of sclerosing cholangitis on IBD
Bedke T, Stumme F, Tomczak M, Steglich B, Jia R, Bohmann S, Wittek A, Kempski J, Göke E, Böttcher M, Reher D, Franke A, Lennartz M, Clauditz T, Sauter G, Fründt T, Weidemann S, Tiegs G, Schramm C, Gagliani N, Pelczar P, Huber S
GUT. 2024;73(8):1292-1301.

Clinical Presentation and Outcome of Critically Ill Patients with Inflammatory Bowel Disease
Böttcher M, Bertram F, Sabihi M, Lücke J, Ahmadi P, Kluge S, Roedl K, Huber S, Wichmann D, Manthey C
VISC MED. 2024;40(2):75-81.

Targeting T cell plasticity in kidney and gut inflammation by pooled single-cell CRISPR screening
Enk L, Hellmig M, Riecken K, Kilian C, Datlinger P, Jauch-Speer S, Neben T, Sultana Z, Sivayoganathan V, Borchers A, Paust H, Zhao Y, Asada N, Liu S, Agalioti T, Pelczar P, Wiech T, Bock C, Huber T, Huber S, Bonn S, Gagliani N, Fehse B, Panzer U, Krebs C
SCI IMMUNOL. 2024;9(96):eadd6774.

Pro- and antitumorigenic functions of γδ T cells
Fiala G, Lücke J, Huber S
EUR J IMMUNOL. 2024;54(8):.

Intestinal epithelia and myeloid immune cells shape colitis severity and colorectal carcinogenesis via High-mobility group box protein 1
Foelsch K, Pelczar P, Zierz E, Kondratowicz S, Qi M, Müller C, Alawi M, Huebener S, Clauditz T, Gagliani N, Huber S, Huebener P
J CROHNS COLITIS. 2024;18(7):1122-1133.

Soluble and EV-bound CD27 act as antagonistic biomarkers in patients with solid tumors undergoing immunotherapy
Gorgulho J, Loosen S, Masood R, Giehren F, Pagani F, Buescher G, Kocheise L, Joerg V, Schmidt C, Schulze K, Roderburg C, Kinkel E, Fritzsche B, Wehmeyer S, Schmidt B, Kachel P, Rolling C, Götze J, Busch A, Sinn M, Pereira-Veiga T, Wikman H, Geffken M, Peine S, Matschl U, Altfeld M, Huber S, Lohse A, Beier F, Brümmendorf T, Bokemeyer C, Luedde T, von Felden J
J EXP CLIN CANC RES. 2024;43(1):298.

Nmes1 is a novel regulator of mucosal response influencing intestinal healing potential
Hamley M, Leyk S, Casar C, Liebold I, Jawazneh A, Lanzloth C, Böttcher M, Haas H, Richardt U, Rothlin C, Jacobs T, Huber S, Adlung L, Pelczar P, Henao-Mejia J, Bosurgi L
EUR J IMMUNOL. 2024;54(2):e2350434.

Longitudinal single-cell data informs deterministic modelling of inflammatory bowel disease
Kilian C, Ulrich H, Zouboulis V, Sprezyna P, Schreiber J, Landsberger T, Büttner M, Biton M, Villablanca E, Huber S, Adlung L
NPJ SYST BIOL APPL. 2024;10(1):69.

Corrigendum: PD-1/PD-L1 immune checkpoint therapy demonstrates favorable safety profile in patients with autoimmune and cholestatic liver disease
Kocheise L, Piseddu I, Vonderlin J, Tjwa E, Buescher G, Meunier L, Goeggelmann P, Fianchi F, Dumortier J, Barciela M, Gevers T, Beretta-Piccoli B, Londoño M, Frankova S, Roesner T, Joerg V, Schmidt C, Glaser F, Sutter J, Fründt T, Lohse A, Huber S, von Felden J, Sebode M, Schulze K
FRONT IMMUNOL. 2024;15:1369747.

Master-naadp: a membrane permeable precursor of the Ca2+ mobilizing second messenger NAADP
Krukenberg S, Möckl F, Weiß M, Dekiert P, Hofmann M, Gerlach F, Winterberg K, Kovacevic D, Khansahib I, Troost B, Hinrichs M, Granato V, Nawrocki M, Hub T, Tsvilovskyy V, Medert R, Woelk L, Förster F, Li H, Werner R, Altfeld M, Huber S, Clarke O, Freichel M, Diercks B, Meier C, Guse A
NAT COMMUN. 2024;15(1):.

IFNγ and CTLA-4 Drive Hepatic CD4 T-Cell Tolerance and Protection From Autoimmunity in Mice
Krzikalla D, Laschtowitz A, Leypoldt L, Gottwick C, Averhoff P, Weidemann S, Lohse A, Huber S, Schramm C, Schwinge D, Herkel J, Carambia A
CELL MOL GASTROENTER. 2024;17(1):79-91.

Apoptotic cell identity induces distinct functional responses to IL-4 in efferocytic macrophages
Liebold I, Al Jawazneh A, Casar C, Lanzloth C, Leyk S, Hamley M, Wong M, Kylies D, Gräfe S, Edenhofer I, Aranda-Pardos I, Kriwet M, Haas H, Krause J, Hadjilaou A, Schromm A, Richardt U, Eggert P, Tappe D, Weidemann S, Ghosh S, Krebs C, A-Gonzalez N, Worthmann A, Lohse A, Huber S, Rothlin C, Puelles V, Jacobs T, Gagliani N, Bosurgi L
SCIENCE. 2024;384(6691):eabo7027.

Obesity and diabetes mellitus are associated with SARS-CoV-2 outcomes without influencing signature genes of extrapulmonary immune compartments at the RNA level
Lücke J, Böttcher M, Nawrocki M, Meins N, Schnell J, Heinrich F, Bertram F, Sabihi M, Seeger P, Pfaff M, Notz S, Blankenburg T, Zhang T, Kempski J, Reeh M, Wolter S, Mann O, Lütgehetmann M, Hackert T, Izbicki J, Duprée A, Huber S, Ondruschka B, Giannou A
HELIYON. 2024;10(2):e24508.

E. coli´s fight against TYROnny: Designing a bacterial strain to tackle tyrosinemia type 1
Lücke J, Huber S
J HEPATOL. 2024;80(3):394-396.

Mouse models of spontaneous liver and lung metastasis for colorectal cancer
Lücke J, Mercanoglu B, Zhang T, Zazara D, Zigmond E, Seeger P, Mann O, Izbicki J, Hackert T, Huber S, Giannou A
STAR PROTOC. 2024;5(1):102811.

Protocol for generating lung and liver metastasis in mice using models that bypass intravasation
Lücke J, Zhang T, Zazara D, Seeger P, Izbicki J, Hackert T, Huber S, Giannou A
STAR PROTOC. 2024;5(1):102696.

Mutual regulation of CD4+ T cells and intravascular fibrin in infections
Mueller T, Pilartz M, Thakur M, LangHeinrich T, Luo J, Block R, Hoeflinger J, Meister S, Karaj F, Perez L, Öllinger R, Engleitner T, Thoss J, Voelkl M, Tersteeg C, Koedel U, Kohlmaier A, Teupser D, Wygrecka M, Ye H, Preissner K, Radbruch H, Elezkurtaj S, Mack M, Von Hundelshausen P, Weber C, Massberg S, Schulz C, Rad R, Huber S, Ishikawa-Ankerhold H, Engelmann B
HAEMATOLOGICA. 2024;109(8):2487-2499.

Preoperative TIPS and in-hospital mortality in patients with cirrhosis undergoing surgery
Piecha F, Vonderlin J, Frühhaber F, Graß J, Ozga A, Harberts A, Benten D, Hübener P, Reeh M, Riedel C, Bannas P, Izbicki J, Adam G, Huber S, Lohse A, Kluwe J
JHEP REP. 2024;6(1):100914.

Serological indication of chronic inflammatory demyelinating polyneuropathy as an extrahepatic manifestation of hepatitis E virus infection
Pischke S, Kjasimov A, Skripuletz T, Casar C, Bannasch J, Mader M, Huber S, Konen F, Wolski A, Horvatits T, Gingele S, Peine S, Hiller J, Seeliger T, Thayssen G, Lütgehetmann M, Schulze Zur Wiesch J, Golsari A, Gelderblom M
SCI REP-UK. 2024;14(1):19244.

Intergenic risk variant rs56258221 skews the fate of naive CD4+ T cells via miR4464-BACH2 interplay in primary sclerosing cholangitis
Poch T, Bahn J, Casar C, Krause J, Evangelakos I, Gilladi H, Kunzmann L, Laschtowitz A, Iuso N, Schäfer A, Liebig L, Steinmann S, Sebode M, Folseraas T, Engesæter L, Karlsen T, Franke A, Metabolic Sciences, Max Delbrück Centre for Molecular Medicine in the Helmholtz Association C, Schlein C, Galun E, Huber S, Lohse A, Gagliani N, Schwinge D, Schramm C
CELL REP MED. 2024;5(7):101620.

Proof of infectivity of hepatitis E virus particles from the ejaculate of chronically infected patients
Schemmerer M, Bock H, Schattenberg J, Huber S, Polywka S, Mader M, Lohse A, Todt D, Steinmann E, Wenzel J, Horvatits T, Pischke S
J MED VIROL. 2024;96(6):.

Does gamma-glutamyltransferase correlate with liver tumor burden in neuroendocrine tumors?
Schmidt B, Leiderer M, Amin T, Viol F, Huber S, Henes F, Schrader J
ENDOCRINE. 2024;83(2):511-518.

Foxp3 + Treg-derived IL-10 promotes colorectal cancer-derived lung metastasis
Shiri A, Fard-Aghaie M, Bedke T, Papazoglou E, Sabihi M, Zazara D, Zhang S, Lücke J, Seeger P, Evers M, Hackert T, Oldhafer K, Gondolesi G, Huber S, Giannou A
SCI REP-UK. 2024;14(1):.

IL-10 dampens antitumor immunity and promotes liver metastasis via PD-L1 induction
Shiri A, Zhang T, Bedke T, Zazara D, Zhao L, Lücke J, Sabihi M, Fazio A, Zhang S, Tauriello D, Batlle E, Steglich B, Kempski J, Agalioti T, Nawrocki M, Xu Y, Riecken K, Liebold I, Brockmann L, Konczalla L, Bosurgi L, Mercanoglu B, Seeger P, Küsters N, Lykoudis P, Heumann A, Arck P, Fehse B, Busch P, Grotelüschen R, Mann O, Izbicki J, Hackert T, Flavell R, Gagliani N, Giannou A, Huber S
J HEPATOL. 2024;80(4):634-644.

Efficacy and safety of palliative treatment in patients with autoimmune liver disease-associated hepatocellular carcinoma
Stern L, Schmidt C, Kocheise L, Joerg V, Casar C, Walter A, Drenth J, Papp M, Gatselis N, Zachou K, Pinter M, Scheiner B, Vogel A, Kirstein M, Finkelmeier F, Waidmann O, Weinmann A, Milkiewicz P, Thorburn D, Halliday N, Lleo A, Huber S, Dalekos G, Lohse A, Wege H, von Felden J, Schulze K
ANN HEPATOL. 2024;29(6):101534.

A protective effect of inflammatory bowel disease on the severity of sclerosing cholangitis
Stumme F, Steffens N, Steglich B, Mathies F, Nawrocki M, Sabihi M, Soukou-Wargalla S, Göke E, Kempski J, Fründt T, Weidemann S, Schramm C, Gagliani N, Huber S, Bedke T
FRONT IMMUNOL. 2024;15:1307297.

Gentamicin combination treatment is associated with lower mortality in patients with invasive listeriosis - a retrospective analysis
Sutter J, Kocheise L, Kempski J, Christner M, Wichmann D, Pinnschmidt H, Schmiedel S, Lohse A, Huber S, Brehm T
INFECTION. 2024;52(4):1601-1606.

All Three AKT Isoforms Can Upregulate Oxygen Metabolism and Lactate Production in Human Hepatocellular Carcinoma Cell Lines
Tian L, Smit D, Popova N, Horn S, Velasquez L, Huber S, Jucker M
INT J MOL SCI. 2024;25(4):.

Mitochondrial perturbation in the intestine causes microbiota-dependent injury and gene signatures discriminative of inflammatory disease
Urbauer E, Aguanno D, Mindermann N, Omer H, Metwaly A, Krammel T, Faro T, Remke M, Reitmeier S, Bärthel S, Kersting J, Huang Z, Xian F, Schmidt M, Saur D, Huber S, Stecher B, List M, Gómez-Varela D, Steiger K, Allez M, Rath E, Haller D
CELL HOST MICROBE. 2024;32(8):1347-1364.e10.

A Gradient of Intestinal Inflammation in Primary Sclerosing Cholangitis
Wittek A, Steglich B, Casar C, Seiz O, Huber P, Ehlken H, Reher D, Wende S, Bedke T, Kempski J, Böttcher M, Bang C, Thingholm L, Krech T, Lohse A, Sauter G, Rösch T, Franke A, Schramm C, Gagliani N, Pelczar P, Huber S
INFLAMM BOWEL DIS. 2024;30(6):900-910.

IL-22 promotes liver regeneration after portal vein ligation
Zhang T, Seeger P, Simsek Y, Sabihi M, Lücke J, Zazara-Giannou D, Shiri M, Kempski J, Blankenburg T, Zhao L, Belios I, Machicote A, Mercanoglu B, Fard-Aghaie M, Notz S, Lykoudis P, Kemper M, Ghadban T, Mann O, Hackert T, Izbicki J, Renne T, Huber S, Giannou A, Li J
HELIYON. 2024;10(6):e27578.

Cancer associated fibroblasts induce proliferation and therapeutic resistance to everolimus in neuroendocrine tumors through STAT3 activation
Amin T, Viol F, Krause J, Fahl M, Eggers C, Awwad F, Schmidt B, Benten D, Ungefroren H, Fraune C, Clauditz T, Sauter G, Izbicki J, Lohse A, Huber S, Schrader J
NEUROENDOCRINOLOGY. 2023;113(5):501-518.

HLA-DP on Epithelial Cells Enables Tissue Damage by NKp44+ Natural Killer Cells in Ulcerative Colitis
Baumdick M, Niehrs A, Degenhardt F, Schwerk M, Hinrichs O, Jordan-Paiz A, Padoan B, Wegner L, Schloer S, Zecher B, Malsy J, Joshi V, Illig C, Schröder-Schwarz J, Möller K, Martin M, Yuki Y, Ozawa M, Sauter J, Schmidt A, Perez D, Giannou A, Carrington M, Davis R, Schumacher U, Sauter G, Huber S, Puelles V, Melling N, Franke A, Altfeld M, Bunders M
GASTROENTEROLOGY. 2023;165(4):946-962.e13.

Stellenwert von Ernährung und Lebensstil
Bertram F, Huber S, Zyriax B
2023. Schwangerschaft und Stillzeit. Zyriax B (Hrsg.). 1. Aufl. München: Elsevier GmbH, 1-6.

Comparative analysis of characteristics and outcomes in hospitalized COVID-19 patients infected with different SARS-CoV-2 variants between January 2020 and April 2022 - A retrospective single-center cohort study
Brehm T, Heyer A, Woo M, Fischer M, van der Meirschen M, Wichmann D, Jarczak D, Roedl K, Schmiedel S, Addo M, Lütgehetmann M, Christner M, Huber S, Lohse A, Kluge S, Schulze Zur Wiesch J
J INFECT PUBLIC HEAL. 2023;16(11):1806-1812.

T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis
Briukhovetska D, Suarez-Gosalvez J, Voigt C, Markota A, Giannou A, Schübel M, Jobst J, Zhang T, Dörr J, Märkl F, Majed L, Müller P, May P, Gottschlich A, Tokarew N, Lücke J, Oner A, Schwerdtfeger M, Andreu-Sanz D, Grünmeier R, Seifert M, Michaelides S, Hristov M, König L, Cadilha B, Mikhaylov O, Anders H, Rothenfusser S, Flavell R, Cerezo-Wallis D, Tejedo C, Soengas M, Bald T, Huber S, Endres S, Kobold S
IMMUNITY. 2023;56(1):143-161.e11.

Myeloid Cell-Specific Deletion of PDGFR-α Promotes Dysbiotic Intestinal Microbiota and thus Increased Colitis Susceptibility
Dörk R, Pelczar P, Shiri A, Volmari A, Zierz E, Giannou A, Böttcher M, Bosurgi L, Huber S, Manthey C
J CROHNS COLITIS. 2023;17(11):1858-1869.

Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22
Giannou A, Kempski J, Shiri A, Lücke J, Zhang T, Zhao L, Zazara D, Cortesi F, Riecken K, Amezcua Vesely M, Low J, Xu H, Kaffe E, Garcia-Perez L, Agalioti T, Yamada Y, Jungraithmayr W, Zigmond E, Karstens K, Steglich B, Wagner J, Konczalla L, Carambia A, Schulze K, von Felden J, May P, Briukhovetska D, Bedke T, Brockmann L, Starzonek S, Lange T, Koch C, Riethdorf S, Pelczar P, Böttcher M, Sabihi M, Huber F, Reeh M, Grass J, Wahib R, Seese H, Stüben B, Fard-Aghaie M, Duprée A, Scognamiglio P, Plitzko G, Meiners J, Soukou S, Wittek A, Manthey C, Maroulis I, Arck P, Perez D, Gao B, Zarogiannis S, Strowig T, Pasqualini R, Arap W, Gosálvez J, Kobold S, Prinz I, Guse A, Tachezy M, Ghadban T, Heumann A, Li J, Melling N, Mann O, Izbicki J, Pantel K, Schumacher U, Lohse A, Flavell R, Gagliani N, Huber S
IMMUNITY. 2023;56(1):125-142.e12.

IL-22BP controls the progression of liver metastasis in colorectal cancer
Giannou A, Kempski J, Zhang T, Lücke J, Shiri A, Zazara D, Belios I, Machicote A, Seeger P, Agalioti T, Tintelnot J, Sagebiel A, Tomczak M, Bauditz L, Bedke T, Kocheise L, Mercanoglu B, Fard-Aghaie M, Giorgakis E, Lykoudis P, Pikouli A, Grass J, Wahib R, Bardenhagen J, Brunswig B, Heumann A, Ghadban T, Duprée A, Tachezy M, Melling N, Arck P, Stringa P, Gentilini M, Gondolesi G, Nakano R, Thomson A, Perez D, Li J, Mann O, Izbicki J, Gagliani N, Maroulis I, Huber S
FRONT ONCOL. 2023;13:1170502.

Protocol for orthotopic single-lung transplantation in mice as a tool for lung metastasis studies
Giannou A, Ohm B, Zazara D, Lücke J, Zhang T, Sabihi M, Seeger P, Oh J, Grotelüschen R, Busch P, Mann O, Hackert T, Izbicki J, Yamada Y, Huber S, Jungraithmayr W
STAR PROTOC. 2023;4(4):102701.

Interferon-induced IL-10 drives systemic T-cell dysfunction during chronic liver injury
Hackstein C, Spitzer J, Symeonidis K, Horvatic H, Bedke T, Steglich B, Klein S, Assmus L, Odainic A, Szlapa J, Kessler N, Beyer M, Schmithausen R, Latz E, Flavell R, Garbi N, Kurts C, Kümmerer B, Trebicka J, Roers A, Huber S, Schmidt S, Knolle P, Abdullah Z
J HEPATOL. 2023;79(1):150-166.

DISCERN: deep single-cell expression reconstruction for improved cell clustering and cell subtype and state detection
Hausmann F, Ergen C, Khatri R, Marouf M, Hänzelmann S, Gagliani N, Huber S, Machart P, Bonn S
GENOME BIOL. 2023;24(1):212.

Cell-Autonomous Constitutive gp130 Signaling in T Cells Amplifies TH17 Cell Responses and Causes Severe Lung Inflammation
Heinig L, Huth E, Yan K, Schumacher N, Nawrocki M, Lory N, Bradtke P, Bertram T, Rattay G, Schmid J, Huber S, Wiech T, Biosciences and Medical Biology, Paris Lodron University Salzburg, Salzburg, Austria D, Rose-John S, Mittrücker H
J IMMUNOL. 2023;210(11):1717-1727.

MELD-Lactate Predicts Poor Outcome in Variceal Bleeding in Cirrhosis
Horvatits T, Mahmud N, Serper M, Seiz O, Reher D, Drolz A, Sarnast N, Gu W, Erasmus H, Allo G, Ferstl P, Wittmann S, Piecha F, Groth S, Zeuzem S, Schramm C, Huber S, Rösch T, Lohse A, Trebicka J, Ogola G, Asrani S, Kluwe J
DIGEST DIS SCI. 2023;68(3):1042-1050.

Efficacy and safety of atezolizumab/bevacizumab in patients with HCC after prior systemic therapy: A global, observational study
Joerg V, Scheiner B, D Alessio A, Fulgenzi C, Schönlein M, Kocheise L, Lohse A, Huber S, Wege H, Kaseb A, Wang Y, Mathew A, Kuang A, Muzaffar M, Abugabal Y, Chamseddine S, Phen S, Cheon J, Lee P, Balcar L, Krall A, Ang C, Wu L, Saeed A, Huang Y, Bengsch B, Rimassa L, Weinmann A, Stauber R, Korolewicz J, Pinter M, Singal A, Chon H, Pinato D, Schulze K, von Felden J
HEPATOL COMMUN. 2023;7(11):.

Macrophages and glia are the dominant P2X7-expressing cell types in the gut nervous system-No evidence for the role of neuronal P2X7 receptors in colitis
Jooss T, Zhang J, Zimmer B, Rezzonico-Jost T, Rissiek B, Felipe Pelczar P, Seehusen F, Koch-Nolte F, Magnus T, Zierler S, Huber S, Schemann M, Grassi F, Nicke A
MUCOSAL IMMUNOL. 2023;16(2):180-193.

PD-1/PD-L1 immune checkpoint therapy demonstrates favorable safety profile in patients with autoimmune and cholestatic liver disease
Kocheise L, Piseddu I, Vonderlin J, Tjwa E, Buescher G, Meunier L, Goeggelmann P, Fianchi F, Dumortier J, Riveiro Barciela M, Gevers T, Terziroli Beretta-Piccoli B, Londoño M, Frankova S, Roesner T, Joerg V, Schmidt C, Glaser F, Sutter J, Fründt T, Lohse A, Huber S, von Felden J, Sebode M, Schulze K
FRONT IMMUNOL. 2023;14:1326078.

EpCAM-positive circulating tumor cells and serum AFP levels predict outcome after curative resection of hepatocellular carcinoma
Kocheise L, Schoenlein M, Behrends B, Joerg V, Casar C, Fründt T, Renné T, Heumann A, Li J, Huber S, Lohse A, Pantel K, Riethdorf S, Wege H, Schulze K, von Felden J
SCI REP-UK. 2023;13(1):20827.

Intestinal B cells license metabolic T-cell activation in NASH microbiota/antigen-independently and contribute to fibrosis by IgA-FcR signalling
Kotsiliti E, Leone V, Schuehle S, Govaere O, Li H, Wolf M, Horvatic H, Bierwirth S, Hundertmark J, Inverso D, Zizmare L, Sarusi-Portuguez A, Gupta R, O'Connor T, Giannou A, Shiri A, Schlesinger Y, Beccaria M, Rennert C, Pfister D, Öllinger R, Gadjalova I, Ramadori P, Rahbari M, Rahbari N, Healy M, Fernández-Vaquero M, Yahoo N, Janzen J, Singh I, Fan C, Liu X, Rau M, Feuchtenberger M, Schwaneck E, Wallace S, Cockell S, Wilson-Kanamori J, Ramachandran P, Kho C, Kendall T, Leblond A, Keppler S, Bielecki P, Steiger K, Hofmann M, Rippe K, Zitzelsberger H, Weber A, Malek N, Luedde T, Vucur M, Augustin H, Flavell R, Parnas O, Rad R, Pabst O, Henderson N, Huber S, Macpherson A, Knolle P, Claassen M, Geier A, Trautwein C, Unger K, Elinav E, Waisman A, Abdullah Z, Haller D, Tacke F, Anstee Q, Heikenwalder M
J HEPATOL. 2023;79(2):296-313.

Intestinal IL-1β Plays a Role in Protecting against SARS-CoV-2 Infection
Lücke J, Heinrich F, Malsy J, Meins N, Schnell J, Böttcher M, Nawrocki M, Zhang T, Bertram F, Sabihi M, Kempski J, Blankenburg T, Duprée A, Reeh M, Wolter S, Mann O, Izbicki J, Lohse A, Gagliani N, Lütgehetmann M, Bunders M, Altfeld M, Sauter G, Giannou A, Krasemann S, Ondruschka B, Huber S
J IMMUNOL. 2023;211(6):1052-1061.

TNFα aggravates detrimental effects of SARS-CoV-2 infection in the liver
Lücke J, Nawrocki M, Schnell J, Meins N, Heinrich F, Zhang T, Bertram F, Sabihi M, Böttcher M, Blankenburg T, Pfaff M, Notz S, Kempski J, Reeh M, Wolter S, Mann O, Izbicki J, Lütgehetmann M, Duprée A, Giannou A, Ondruschka B, Huber S
FRONT IMMUNOL. 2023;14:1151937.

Muscle quality determined by computed tomography predicts short-term and long-term survival after liver transplantation
Molwitz I, Recklies F, Stark M, Horvatits T, Salamon J, Huber S, Fischer L, Adam G, Lohse A, Sterneck M, Horvatits K
SCI REP-UK. 2023;13(1):7631.

IRF4 is required for migration of CD4+ T cells to the intestine but not for Th2 and Th17 cell maintenance
Schmidt C, Harberts A, Reimers D, Bertram T, Voß L, Schmid J, Lory N, Spohn M, Koch-Nolte F, Huber S, Raczkowski F, Breloer M, Mittrücker H
FRONT IMMUNOL. 2023;14:1182502.

Short-term dietary changes can result in mucosal and systemic immune depression
Siracusa F, Schaltenberg N, Kumar Y, Lesker T, Steglich B, Liwinski T, Cortesi F, Frommann L, Diercks B, Bönisch F, Fischer A, Scognamiglio P, Pauly M, Casar C, Cohen Y, Pelczar P, Agalioti T, Delfs F, Worthmann A, Wahib R, Jagemann B, Mittrücker H, Kretz O, Guse A, Izbicki J, Lassen K, Strowig T, Schweizer M, Villablanca E, Elinav E, Huber S, Heeren J, Gagliani N
NAT IMMUNOL. 2023;24(9):1473-1486.

Tr1 Cells Emerge and Suppress Effector Th17 Cells in Glomerulonephritis
Soukou-Wargalla S, Kilian C, Velasquez L, Machicote A, Letz P, Tran H, Domanig S, Bertram F, Stumme F, Bedke T, Giannou A, Kempski J, Sabihi M, Song N, Paust H, Borchers A, Garcia Perez L, Pelczar P, Liu B, Ergen C, Steglich B, Muscate F, Huber T, Panzer U, Gagliani N, Krebs C, Huber S
J IMMUNOL. 2023;211(11):1669-1679.

Enabling X-ray fluorescence imaging for in vivo immune cell tracking
Staufer T, Körnig C, Liu B, Liu Y, Lanzloth C, Schmutzler O, Bedke T, Machicote A, Parak W, Feliu N, Bosurgi L, Huber S, Grüner F
SCI REP-UK. 2023;13(1):11505.

Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer
Tintelnot J, Xu Y, Lesker T, Schönlein M, Konczalla L, Giannou A, Pelczar P, Kylies D, Puelles V, Bielecka A, Peschka M, Cortesi F, Riecken K, Jung M, Amend L, Bröring T, Trajkovic-Arsic M, Siveke J, Renné T, Zhang D, Boeck S, Strowig T, Uzunoglu F, Güngör C, Stein A, Izbicki J, Bokemeyer C, Sinn M, Kimmelman A, Huber S, Gagliani N
NATURE. 2023;615(7950):168-174.

Adhesion to laminin-1 and collagen IV induces the formation of Ca2+ microdomains that sensitize mouse T cells for activation
Weiß M, Hernandez L, Gil Montoya D, Löhndorf A, Krüger A, Kopdag M, Uebler L, Landwehr M, Nawrocki M, Huber S, Woelk L, Werner R, Failla A, Flügel A, Dupont G, Guse A, Diercks B
SCI SIGNAL. 2023;16(790):eabn9405.

Evidence for broad cross-reactivity of the SARS-CoV-2 NSP12-directed CD4+ T-cell response with pre-primed responses directed against common cold coronaviruses
Westphal T, Mader M, Karsten H, Cords L, Knapp M, Schulte S, Hermanussen L, Peine S, Ditt V, Grifoni A, Addo M, Huber S, Sette A, Lütgehetmann M, Pischke S, Kwok W, Sidney J, Schulze Zur Wiesch J
FRONT IMMUNOL. 2023;14:.

Multicytokine-producing CD4+ T cells characterize the livers of patients with NASH
Woestemeier A, Scognamiglio P, Zhao Y, Wagner J, Muscate F, Casar C, Siracusa F, Cortesi F, Agalioti T, Müller S, Sagebiel A, Konczalla L, Wahib R, Karstens K, Giannou A, Duprée A, Wolter S, Wong M, Mühlig A, Bielecka A, Bansal V, Zhang T, Mann O, Puelles V, Huber T, Lohse A, Izbicki J, Palm N, Bonn S, Huber S, Gagliani N
JCI INSIGHT. 2023;8(1):.

CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis
Zhang T, Wahib R, Zazara D, Lücke J, Shiri A, Kempski J, Zhao L, Agalioti T, Machicote A, Giannou O, Belios I, Jia R, Zhang S, Tintelnot J, Seese H, Grass J, Mercanoglu B, Stern L, Scognamiglio P, Fard-Aghaie M, Seeger P, Wakker J, Kemper M, Brunswig B, Duprée A, Lykoudis P, Pikouli A, Giorgakis E, Stringa P, Lausada N, Gentilini M, Gondolesi G, Bachmann K, Busch P, Grotelüschen R, Maroulis I, Arck P, Nakano R, Thomson A, Ghadban T, Tachezy M, Melling N, Achilles E, Puelles V, Nickel F, Hackert T, Mann O, Izbicki J, Li J, Gagliani N, Huber S, Giannou A
ONCOIMMUNOLOGY. 2023;12(1):2269634.

Characterization of serum biomarkers and antibody responses against Prevotella spp. in preclinical and new-onset phase of rheumatic diseases
Amend L, Gilbert B, Pelczar P, Böttcher M, Huber S, Witte T, Finckh A, Strowig T
FRONT CELL INFECT MI. 2022;12:1096211.

Th17 cell plasticity towards a T-bet-dependent Th1 phenotype is required for bacterial control in Staphylococcus aureus infection
Bartsch P, Kilian C, Hellmig M, Paust H, Borchers A, Sivayoganathan A, Enk L, Zhao Y, Shaikh N, Büttner H, Wong M, Puelles V, Wiech T, Flavell R, Huber T, Turner J, Bonn S, Huber S, Gagliani N, Mittrücker H, Rohde H, Panzer U, Krebs C
PLOS PATHOG. 2022;18(4):e1010430.

Three Separate Spike Antigen Exposures by COVID-19 Vaccination or SARS-CoV-2 Infection Elicit Strong Humoral Immune Responses in Healthcare Workers
Brehm T, Ullrich F, Thompson M, Küchen J, Schwinge D, Spier A, Huber S, Knobloch J, Aepfelbacher M, Addo M, Lohse A, Lütgehetmann M, Schulze Zur Wiesch J
VACCINES-BASEL. 2022;10(7):.

Transabdominal Ultrasound and Magnetic Resonance Enterography in Inflammatory Bowel Disease: Results of an Observational Retrospective Single-Center Study
Calavrezos L, Bannas P, Warncke M, Wiegard C, Huber S, Manthey C
ULTRASOUND INT OPEN. 2022;8(1):E22-E28.

High and Sustained Ex Vivo Frequency but Altered Phenotype of SARS-CoV-2-Specific CD4+ T-Cells in an Anti-CD20-Treated Patient with Prolonged COVID-19
Cords L, Knapp M, Woost R, Schulte S, Kummer S, Ackermann C, Beisel C, Peine S, Johansson A, Kwok W, Günther T, Fischer N, Wittner M, Addo M, Huber S, Schulze Zur Wiesch J
VIRUSES-BASEL. 2022;14(6):.

Possible tumour cell reimplantation during curative endoscopic therapy of superficial Barrett's carcinoma
Ehlken H, Schmitz R, Riethdorf S, Riethdorf L, Krause J, Karstens K, Schrader J, Viol F, Giannou A, Sterlacci W, Vieth M, Clauditz T, Kähler C, Mann O, Izbicki J, Huber S, Pantel K, Rösch T
GUT. 2022;71(2):277-286.

DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon
Fazio A, Bordoni D, Kuiper J, Weber-Stiehl S, Stengel S, Arnold P, Ellinghaus D, Ito G, Tran F, Messner B, Henning A, Bernardes J, Häsler R, Luzius A, Imm S, Hinrichsen F, Franke A, Huber S, Nikolaus S, Aden K, Schreiber S, Sommer F, Natoli G, Mishra N, Rosenstiel P
NAT COMMUN. 2022;13:.

Equal Efficacy and Safety Profile in Elderly Patients with Hepatocellular Carcinoma Receiving Palliative Treatment
Fründt T, Casar C, von Felden J, Schöler U, Priebe M, Kraczyk J, Ahrend H, Salamon J, Adam G, Huber S, Lohse A, Wege H, Schulze K
CANCERS. 2022;14(3):.

Circulating tumor cells as a preoperative risk marker for occult metastases in patients with resectable cholangiocarcinoma
Fründt T, von Felden J, Krause J, Heumann A, Li J, Riethdorf S, Pantel K, Huber S, Lohse A, Wege H, Schulze K
FRONT ONCOL. 2022;12:.

A Critical Role of the IL-22-IL-22 Binding Protein Axis in Hepatocellular Carcinoma
Giannou A, Lücke J, Kleinschmidt D, Shiri A, Steglich B, Nawrocki M, Zhang T, Zazara D, Kempski J, Zhao L, Giannou O, Agalioti T, Brockmann L, Bertram F, Sabihi M, Böttcher M, Ewald F, Schulze K, von Felden J, Machicote A, Maroulis I, Arck P, Graß J, Mercanoglu B, Reeh M, Wolter S, Tachezy M, Seese H, Theodorakopoulou M, Lykoudis P, Heumann A, Uzunoglu F, Ghadban T, Mann O, Izbicki J, Li J, Duprée A, Melling N, Gagliani N, Huber S
CANCERS. 2022;14(24):.

Microplastics detected in cirrhotic liver tissue
Horvatits T, Tamminga M, Liu B, Sebode M, Carambia A, Fischer L, Püschel K, Huber S, Fischer E
EBIOMEDICINE. 2022;82:.

High-resolution analysis of individual spike peptide-specific CD4+ T-cell responses in vaccine recipients and COVID-19 patients
Karsten H, Cords L, Westphal T, Knapp M, Brehm T, Hermanussen L, Omansen T, Schmiedel S, Woost R, Ditt V, Peine S, Lütgehetmann M, Huber S, Ackermann C, Wittner M, Addo M, Sette A, Sidney J, Schulze Zur Wiesch J
CLIN TRANSL IMMUNOL. 2022;11(8):.

Das Darmmikrobiom in der Pathogenese und Therapie chronisch-entzündlicher Darmerkrankungen
Kempski J, Huber S
INNERE MED. 2022;63(10):1022-1027.

In-situ x-ray fluorescence imaging of the endogenous iodine distribution in murine thyroids
Körnig C, Staufer T, Schmutzler O, Bedke T, Machicote A, Liu B, Liu Y, Gargioni E, Feliu N, Parak W, Huber S, Grüner F
SCI REP-UK. 2022;12(1):2903.

Magen/Darm- und Lebererkrankungen
Lohse A, Huber S
2022. Arzneiverordnungs-Report 2022. Ludwig W, Mühlbauer B, Seifert R (Hrsg.). 1. Aufl. Berlin: Springer-Verlag Berlin, Heidelberg, 303-329.

TRPM2 Is Not Required for T-Cell Activation and Differentiation
Lory N, Nawrocki M, Corazza M, Schmid J, Schumacher V, Bedke T, Menzel S, Koch-Nolte F, Guse A, Huber S, Mittrücker H
FRONT IMMUNOL. 2022;12:.

Disturbed lipid and amino acid metabolisms in COVID-19 patients
Masoodi M, Peschka M, Schmiedel S, Haddad M, Frye M, Maas C, Lohse A, Huber S, Kirchhof P, Nofer J, Renné T
J MOL MED. 2022;100(4):555-568.

Evidence of surface contamination in hospital rooms occupied by patients infected with monkeypox, Germany, June 2022
Nörz D, Pfefferle S, Brehm T, Franke G, Grewe I, Knobling B, Aepfelbacher M, Huber S, Klupp E, Jordan S, Addo M, Schulze Zur Wiesch J, Schmiedel S, Lütgehetmann M, Knobloch J
EUROSURVEILLANCE. 2022;27(26):.

Chronisch-entzündliche Darmerkrankungen: Therapiealgorithmus 2021
Reher D, Manthey C, Huber S
tägliche praxis. 2022;2022(66/3):373-389.

Novel preclinical gastroenteropancreatic neuroendocrine neoplasia models demonstrate the feasibility of mutation-based targeted therapy
Viol F, Sipos B, Fahl M, Clauditz T, Amin T, Kriegs M, Nieser M, Izbicki J, Huber S, Lohse A, Schrader J
CELL ONCOL. 2022;45(6):1401-1419.

High risk of complications and acute-on-chronic liver failure in cirrhosis patients with acute pancreatitis
Vogel M, Ehlken H, Kluge S, Roesch T, Lohse A, Huber S, Sterneck M, Hübener P
EUR J INTERN MED. 2022;102:54-62.

Tissue Sampling and Homogenization with NIRL Enables Spatially Resolved Cell Layer Specific Proteomic Analysis of the Murine Intestine
Voß H, Moritz M, Pelczar P, Gagliani N, Huber S, Nippert V, Schlüter H, Hahn J
INT J MOL SCI. 2022;23(11):.

Molecular consequences of SARS-CoV-2 liver tropism
Wanner N, Andrieux G, Badia-I-Mompel P, Edler C, Pfefferle S, Lindenmeyer M, Schmidt-Lauber C, Czogalla J, Wong M, Okabayashi Y, Braun F, Lütgehetmann M, Meister E, Lu S, Noriega M, Günther T, Grundhoff A, Fischer N, Bräuninger H, Lindner D, Westermann D, Haas F, Roedl K, Kluge S, Addo M, Huber S, Lohse A, Reiser J, Ondruschka B, Sperhake J, Saez-Rodriguez J, Boerries M, Hayek S, Aepfelbacher M, Scaturro P, Puelles V, Huber T
NAT METAB. 2022;4(3):310-319.

Transcriptional Pattern Analysis of Virus-Specific CD8+ T Cells in Hepatitis C Infection: Increased Expression of TOX and Eomesodermin During and After Persistent Antigen Recognition
Wildner N, Walker A, Brauneck F, Ditt V, Peine S, Huber S, Haag F, Beisel C, Timm J, Schulze Zur Wiesch J
FRONT IMMUNOL. 2022;13:.

CD4+ T-cell-derived IL-10 promotes CNS inflammation in mice by sustaining effector T cell survival
Yogev N, Bedke T, Kobayashi Y, Brockmann L, Lukas D, Regen T, Croxford A, Nikolav A, Hövelmeyer N, von Stebut E, Prinz M, Ubeda C, Maloy K, Gagliani N, Flavell R, Waisman A, Huber S
CELL REP. 2022;38(13):.

Patient Characteristics and Clinical Course of COVID-19 Patients Treated at a German Tertiary Center during the First and Second Waves in the Year 2020
Brehm T, Heyer A, Roedl K, Jarczak D, Nierhaus A, Nentwich M, van der Meirschen M, Schultze A, Christner M, Fiedler W, Kröger N, Huber T, Klose H, Sterneck M, Jordan S, Kreuels B, Schmiedel S, Addo M, Huber S, Lohse A, Kluge S, Schulze Zur Wiesch J
J CLIN MED. 2021;10(11):.

Seroprevalence of SARS-CoV-2 antibodies among hospital workers in a German tertiary care center: A sequential follow-up study
Brehm T, Schwinge D, Lampalzer S, Schlicker V, Küchen J, Thompson M, Ullrich F, Huber S, Schmiedel S, Addo M, Lütgehetmann M, Knobloch J, Schulze Zur Wiesch J, Lohse A
INT J HYG ENVIR HEAL. 2021;232:.

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
Cossarizza A, Chang H, Radbruch A, Abrignani S, Addo R, Akdis M, Andrä I, Andreata F, Annunziato F, Arranz E, Bacher P, Bari S, Barnaba V, Barros-Martins J, Baumjohann D, Beccaria C, Bernardo D, Boardman D, Borger J, Böttcher C, Brockmann L, Burns M, Busch D, Cameron G, Cammarata I, Cassotta A, Chang Y, Chirdo F, Christakou E, Čičin-Šain L, Cook L, Corbett A, Cornelis R, Cosmi L, Davey M, De Biasi S, De Simone G, Del Zotto G, Delacher M, Di Rosa F, Santo J, Diefenbach A, Dong J, Dörner T, Dress R, Dutertre C, Eckle S, Eede P, Evrard M, Falk C, Feuerer M, Fillatreau S, Fiz-Lopez A, Follo M, Foulds G, Fröbel J, Gagliani N, Galletti G, Gangaev A, Garbi N, Garrote J, Geginat J, Gherardin N, Gibellini L, Ginhoux F, Godfrey D, Gruarin P, Haftmann C, Hansmann L, Harpur C, Hayday A, Heine G, Hernández D, Herrmann M, Hoelsken O, Huang Q, Huber S, Huber J, Huehn J, Hundemer M, Hwang W, Iannacone M, Ivison S, Jäck H, Jani P, Keller B, Kessler N, Ketelaars S, Knop L, Knopf J, Koay H, Kobow K, Kriegsmann K, Kristyanto H, Krueger A, Kuehne J, Kunze-Schumacher H, Kvistborg P, Kwok I, Latorre D, Lenz D, Levings M, Lino A, Liotta F, Long H, Lugli E, MacDonald K, Maggi L, Maini M, Mair F, Manta C, Manz R, Mashreghi M, Mazzoni A, McCluskey J, Mei H, Melchers F, Melzer S, Mielenz D, Monin L, Moretta L, Multhoff G, Muñoz L, Muñoz-Ruiz M, Muscate F, Natalini A, Neumann K, Ng L, Niedobitek A, Niemz J, Almeida L, Notarbartolo S, Ostendorf L, Pallett L, Patel A, Percin G, Peruzzi G, Pinti M, Pockley A, Pracht K, Prinz I, Pujol-Autonell I, Pulvirenti N, Quatrini L, Quinn K, Radbruch H, Rhys H, Rodrigo M, Romagnani C, Saggau C, Sakaguchi S, Sallusto F, Sanderink L, Sandrock I, Schauer C, Scheffold A, Scherer H, Schiemann M, Schildberg F, Schober K, Schoen J, Schuh W, Schüler T, Schulz A, Schulz S, Schulze J, Simonetti S, Singh J, Sitnik K, Stark R, Starossom S, Stehle C, Szelinski F, Tan L, Tarnok A, Tornack J, Tree T, van Beek J, van de Veen W, van Gisbergen K, Vasco C, Verheyden N, von Borstel A, Ward-Hartstonge K, Warnatz K, Waskow C, Wiedemann A, Wilharm A, Wing J, Wirz O, Wittner J, Yang J, Yang J
EUR J IMMUNOL. 2021;51(12):2708-3145.

T cell cytokines in the diagnostic of early-onset sepsis
Froeschle G, Bedke T, Boettcher M, Huber S, Singer D, Ebenebe C
PEDIATR RES. 2021;90(1):191-196.

Low incidence of COVID-19 in a prospective cohort of patients with liver cirrhosis and hepatocellular carcinoma treated at a tertiary medical center during the 2020 pandemic
Fründt T, Kuballa L, Lütgehetman M, Nörz D, Arend H, Brehm T, Schulze Zur Wiesch J, Horvatits T, Horvatits K, Huber S, Wege H, Kluwe J
PLOS ONE. 2021;16(12):e0258450.

Liver transplantation for acute‐on‐chronic liver failure predicts post‐transplant mortality and impaired long‐term quality of life
Goosmann L, Buchholz A, Bangert K, Fuhrmann V, Kluge S, Lohse A, Huber S, Fischer L, Sterneck M, Hübener P
LIVER INT. 2021;41(3):574-584.

Validation of a Prospective Urinalysis-Based Prediction Model for ICU Resources and Outcome of COVID-19 Disease: A Multicenter Cohort Study
Gross O, Moerer O, Rauen T, Böckhaus J, Hoxha E, Jörres A, Kamm M, Elfanish A, Windisch W, Dreher M, Floege J, Kluge S, Schmidt-Lauber C, Turner J, Huber S, Addo M, Scheithauer S, Friede T, Braun G, Huber T, Blaschke S
J CLIN MED. 2021;10(14):.

Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca2+ signaling during T cell activation
Gu F, Krüger A, Roggenkamp H, Alpers R, Lodygin D, Jaquet V, Möckl F, Hernandez C L, Winterberg K, Bauche A, Rosche A, Grasberger H, Kao J, Schetelig D, Werner R, Schröder K, Carty M, Bowie A, Huber S, Meier C, Mittrücker H, Heeren J, Krause K, Flügel A, Diercks B, Guse A
SCI SIGNAL. 2021;14(709):.

Tissue Sampling and Homogenization in the Sub-Microliter Scale with a Nanosecond Infrared Laser (NIRL) for Mass Spectrometric Proteomics
Hahn J, Moritz M, Voß H, Pelczar P, Huber S, Schlüter H
INT J MOL SCI. 2021;22(19):.

Malaria in the Time of COVID-19: Do Not Miss the Real Cause of Illness
Jochum J, Kreuels B, Tannich E, Huber S, Schulze Zur Wiesch J, Schmiedel S, Ramharter M, Addo M
TROP MED INFECT DIS. 2021;6(2):.

Convalescent plasma treatment for early post-kidney-transplant acquired COVID-19
Kluger M, Czogalla J, Schmidt-Lauber C, Peine S, Schmiedel S, Bangert K, Kluge S, Huber S, Puelles V, Fischer L, Huber T, Grahammer F
TRANSPL INFECT DIS. 2021;23(4):e13685.

Magen-Darm-Mittel und Lebertherapeutika
Lohse A, Huber S
2021. Arzneiverordnungs-Report 2021. Ludwig W, Mühlbauer B, Seifert R (Hrsg.). 1. Aufl. Berlin: Springer-Verlag, Berlin, 523-550.

The good and the bad about separation anxiety: roles of IL-22 and IL-22BP in liver pathologies
Lücke J, Sabihi M, Zhang T, Bauditz L, Shiri A, Giannou A, Huber S
SEMIN IMMUNOPATHOL. 2021;43(4):591-607.

Rationalizing heptadecaphobia: TH 17 cells and associated cytokines in cancer and metastasis
Lücke J, Shiri A, Zhang T, Kempski J, Giannou A, Huber S
FEBS J. 2021;288(24):6942-6971.

Was ist gesichert in der Therapie chronisch-entzündlicher Darmerkrankungen
Manthey C, Reher D, Huber S
INTERNIST. 2021;62(12):1269-1279.

Trans-Ned 19-Mediated Antagonism of Nicotinic Acid Adenine Nucleotide—Mediated Calcium Signaling Regulates Th17 Cell Plasticity in Mice
Nawrocki M, Lory N, Bedke T, Stumme F, Diercks B, Guse A, Meier C, Gagliani N, Mittrücker H, Huber S
CELLS-BASEL. 2021;10(11):.

Interleukin-10 improves stroke outcome by controlling the detrimental Interleukin-17A response
Piepke M, Clausen B, Ludewig P, Vienhues J, Bedke T, Javidi E, Rissiek B, Jank L, Brockmann L, Sandrock I, Degenhardt K, Jander A, Roth V, Schädlich I, Prinz I, Flavell R, Kobayashi Y, Renné T, Gerloff C, Huber S, Magnus T, Gelderblom M
J NEUROINFLAMM. 2021;18(1):.

Single-cell atlas of hepatic T cells reveals expansion of liver-resident naive-like CD4+ T cells in primary sclerosing cholangitis
Poch T, Krause J, Casar C, Liwinski T, Glau L, Kaufmann M, Ahrenstorf A, Hess L, Ziegler A, Martrus G, Lunemann S, Sebode M, Li J, Schwinge D, Krebs C, Franke A, Friese M, Oldhafer K, Fischer L, Altfeld M, Lohse A, Huber S, Tolosa E, Gagliani N, Schramm C
J HEPATOL. 2021;75(2):414-423.

Induction of IL-22-Producing CD4+ T Cells by Segmented Filamentous Bacteria Independent of Classical Th17 Cells
Roy U, de Oliveira R, Galvez E, Gronow A, Basic M, Perez L, Gagliani N, Bleich A, Huber S, Strowig T
FRONT IMMUNOL. 2021;12:671331.

X-ray-Based Techniques to Study the Nano-Bio Interface
Sanchez-Cano C, Alvarez-Puebla R, Abendroth J, Beck T, Blick R, Cao Y, Caruso F, Chakraborty I, Chapman H, Chen C, Cohen B, Conceição A, Cormode D, Cui D, Dawson K, Falkenberg G, Fan C, Feliu N, Gao M, Gargioni E, Glüer C, Grüner F, Hassan M, Hu Y, Huang Y, Huber S, Huse N, Kang Y, Khademhosseini A, Keller T, Körnig C, Kotov N, Koziej D, Liang X, Liu B, Liu S, Liu Y, Liu Z, Liz-Marzán L, Ma X, Machicote A, Maison W, Mancuso A, Megahed S, Nickel B, Otto F, Palencia C, Pascarelli S, Pearson A, Peñate-Medina O, Qi B, Rädler J, Richardson J, Rosenhahn A, Rothkamm K, Rübhausen M, Sanyal M, Schaak R, Schlemmer H, Schmidt M, Schmutzler O, Schotten T, Schulz F, Sood A, Spiers K, Staufer T, Stemer D, Stierle A, Sun X, Tsakanova G, Weiss P, Weller H, Westermeier F, Xu M, Yan H, Zeng Y, Zhao Y, Zhao Y, Zhu D, Zhu Y, Parak W
ACS NANO. 2021;15(3):3754-3807.

IL-17 receptor c signaling controls CD4⁺T_H17 immune responses and tissue injury in immune-mediated kidney diseases
Schmidt T, Luebbe J, Kilian C, Riedel J, Hiekmann S, Asada N, Ginsberg P, Robben L, Song N, Kaffke A, Peters A, Borchers A, Flavell R, Gagliani N, Pelzcar P, Huber S, Huber T, Turner J, Paust H, Krebs C, Panzer U
J AM SOC NEPHROL. 2021;32(12):3081-3098.

T cell plasticity in renal autoimmune disease
Soukou S, Huber S, Krebs C
CELL TISSUE RES. 2021;385(2):323-333.

Leukocyte-Derived High-Mobility Group Box 1 Governs Hepatic Immune Responses to Listeria monocytogenes
Volmari A, Foelsch K, Zierz E, Yan K, Qi M, Bartels K, Kondratowicz S, Boettcher M, Reimers D, Nishibori M, Liu K, Schwabe R, Lohse A, Huber S, Mittruecker H, Hübener P
HEPATOL COMMUN. 2021;5(12):2104-2120.

Multi-dimensional and longitudinal systems profiling reveals predictive pattern of severe COVID-19
Woo M, Haag F, Nierhaus A, Jarczak D, Roedl K, Mayer C, Brehm T, van der Meirschen M, Hennigs A, Christopeit M, Fiedler W, Karagiannis P, Burdelski C, Schultze A, Huber S, Addo M, Schmiedel S, Friese M, Kluge S, Schulze Zur Wiesch J
ISCIENCE. 2021;24(7):102752.

Efferocytosis fuels malignant pleural effusion through TIMP1
Zhao L, Giannou A, Xu Y, Shiri A, Liebold I, Steglich B, Bedke T, Zhang T, Lücke J, Scognamiglio P, Kempski J, Woestemeier A, Chen J, Agalioti T, Zazara D, Lindner D, Janning M, Hennigs J, Jagirdar R, Kotsiou O, Zarogiannis S, Kobayashi Y, Izbicki J, Ghosh S, Rothlin C, Bosurgi L, Huber S, Gagliani N
SCI ADV. 2021;7(33):.

Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients
Zhao Y, Kilian C, Turner J, Bosurgi L, Roedl K, Bartsch P, Gnirck A, Cortesi F, Schultheiß C, Hellmig M, Enk L, Hausmann F, Borchers A, Wong M, Paust H, Siracusa F, Scheibel N, Herrmann M, Rosati E, Bacher P, Kylies D, Jarczak D, Lütgehetmann M, Pfefferle S, Steurer S, Zur Wiesch J, Puelles V, Sperhake J, Addo M, Lohse A, Binder M, Huber S, Huber T, Kluge S, Bonn S, Panzer U, Gagliani N, Krebs C
SCI IMMUNOL. 2021;6(56):.

Defining the CD39/CD73 Axis in SARS-CoV-2 Infection: The CD73- Phenotype Identifies Polyfunctional Cytotoxic Lymphocytes
Ahmadi P, Hartjen P, Kohsar M, Kummer S, Schmiedel S, Bockmann J, Fathi A, Huber S, Haag F, Schulze Zur Wiesch J
CELLS-BASEL. 2020;9(8):.

NK cell receptor NKG2D enforces proinflammatory features and pathogenicity of Th1 and Th17 cells
Babic M, Dimitropoulos C, Hammer Q, Stehle C, Heinrich F, Sarsenbayeva A, Eisele A, Durek P, Mashreghi M, Lisnic B, Van Snick J, Löhning M, Fillatreau S, Withers D, Gagliani N, Huber S, Flavell R, Polic B, Romagnani C
J EXP MED. 2020;217(8):.

IgG Fc sialylation is regulated during the germinal center reaction following immunization with different adjuvants
Bartsch Y, Eschweiler S, Leliavski A, Lunding H, Wagt S, Petry J, Lilienthal G, Rahmöller J, de Haan N, Hölscher A, Erapaneedi R, Giannou A, Aly L, Sato R, de Neef L, Winkler A, Braumann D, Hobusch J, Kuhnigk K, Krémer V, Steinhaus M, Blanchard V, Gemoll T, Habermann J, Collin M, Salinas G, Manz R, Fukuyama H, Korn T, Waisman A, Yogev N, Huber S, Germany I, Rose-John S, Busch H, Berberich-Siebelt F, Hölscher C, Netherlands C, Ehlers M
J ALLERGY CLIN IMMUN. 2020;146(3):652-666.e11.

Microbiota-Propelled T Helper 17 Cells in Inflammatory Diseases and Cancer
Bellone M, Brevi A, Huber S
MICROBIOL MOL BIOL R. 2020;84(2):.

High effectiveness of multimodal infection control interventions in preventing SARS−CoV−2 infections in healthcare professionals: a prospective longitudinal seroconversion study
Brehm T, Schwinge D, Lampalzer S, Schlicker V, Küchen J, Thompson M, Ullrich F, Huber S, Schmiedel S, Addo M, Lütgehetmann M, Knobloch J, Schulze zur Wiesch J, Lohse A
medRxiv BMJ. 2020.

Systemic interleukin 10 levels indicate advanced stages while interleukin 17A levels correlate with reduced survival in esophageal adenocarcinomas
Karstens K, Kempski J, Giannou A, Freiwald E, Reeh M, Tachezy M, Izbicki J, Lohse A, Gagliani N, Huber S, Pelczar P
PLOS ONE. 2020;15(4):e0231833.

Anti-inflammatory microenvironment of esophageal adenocarcinomas negatively impacts survival
Karstens K, Kempski J, Giannou A, Pelczar P, Steglich B, Steurer S, Freiwald E, Woestemeier A, Konczalla L, Tachezy M, Reeh M, Bockhorn M, Perez D, Mann O, Lohse A, Roesch T, Izbicki J, Gagliani N, Huber S
CANCER IMMUNOL IMMUN. 2020;69(6):1043-1056.

IL22BP Mediates the Anti-Tumor Effects of Lymphotoxin Against Colorectal Tumors in Mice and Humans
Kempski J, Giannou A, Riecken K, Zhao L, Steglich B, Lücke J, Garcia-Perez L, Karstens K, Wöstemeier A, Nawrocki M, Pelczar P, Witkowski M, Nilsson S, Konczalla L, Shiri A, Kempska J, Wahib R, Brockmann L, Huber P, Gnirck A, Turner J, Zazara D, Arck P, Stein A, Simon R, Daubmann A, Meiners J, Perez D, Strowig T, Koni P, Kruglov A, Sauter G, Izbicki J, Guse A, Roesch T, Lohse A, Flavell R, Gagliani N, Huber S
GASTROENTEROLOGY. 2020;159(4):1417-1430.e3.

Therapeutic Targeting of Myeloperoxidase Attenuates NASH in Mice
Koop A, Thiele N, Steins D, Michaëlsson E, Wehmeyer M, Scheja L, Steglich B, Huber S, Schulze zur Wiesch J, Lohse A, Heeren J, Kluwe J
HEPATOL COMMUN. 2020;4(10):1441-1458.

Pathogen-induced tissue-resident memory TH17 (TRM17) cells amplify autoimmune kidney disease
Krebs C, Reimers D, Zhao Y, Paust H, Bartsch P, Nuñez S, Rosemblatt M, Hellmig M, Kilian C, Borchers A, Enk L, Zinke M, Becker M, Schmid J, Klinge S, Wong M, Puelles V, Schmidt C, Bertram T, Stumpf N, Hoxha E, Meyer-Schwesinger C, Lindenmeyer M, Cohen C, Rink M, Kurts C, Franzenburg S, Koch-Nolte F, Turner J, Riedel J, Huber S, Gagliani N, Huber T, Wiech T, Rohde H, Bono M, Bonn S, Panzer U, Mittrücker H
SCI IMMUNOL. 2020;5(50):.

Monocytes as potential mediators of pathogen-induced Th17 differentiation in patients with primary sclerosing cholangitis (PSC)
Kunzmann L, Schoknecht T, Poch T, Henze L, Stein S, Kriz M, Grewe I, Preti M, Hartl J, Pannicke N, Peiseler M, Sebode M, Zenouzi R, Horvatits T, Böttcher M, Petersen B, Weiler-Normann C, Hess L, Ahrenstorf A, Lunemann S, Martrus G, Fischer L, Li J, Carambia A, Kluwe J, Huber S, Lohse A, Franke A, Herkel J, Schramm C, Schwinge D
HEPATOLOGY. 2020;72(4):1310-1326.

Decreased Frequency of Intestinal CD39+ γδ+ T Cells With Tissue-Resident Memory Phenotype in Inflammatory Bowel Disease
Libera J, Wittner M, Kantowski M, Woost R, Eberhard J, de Heer J, Reher D, Huber S, Haag F, Schulze Zur Wiesch J
FRONT IMMUNOL. 2020;11:567472.

Sustained response after remdesivir and convalescent plasma therapy in a B-cell depleted patient with protracted COVID-19
Malsy J, Veletzky L, Heide J, Hennigs A, Gil-Ibanez I, Stein A, Lütgehetmann M, Rosien U, Jasper D, Peine S, Hiller J, Haag F, Schmiedel S, Huber S, Jordan S, Addo M, Schulze Zur Wiesch J
CLIN INFECT DIS. 2020;73(11):e4020–e4024.

Publisher Correction: TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer
Perez L, Kempski J, McGee H, Pelzcar P, Agalioti T, Giannou A, Konczalla L, Brockmann L, Wahib R, Xu H, Vesely M, Soukou S, Steglich B, Bedke T, Manthey C, Seiz O, Diercks B, Gnafakis S, Guse A, Perez D, Izbicki J, Gagliani N, Flavell R, Huber S
NAT COMMUN. 2020.

TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer
Perez L, Kempski J, M McGee H, Pelzcar P, Agalioti T, Giannou A, Konczalla L, Brockmann L, Wahib R, Xu H, Vesely M, Soukou S, Steglich B, Bedke T, Manthey C, Seiz O, Diercks B, Gnafakis S, Guse A, Perez D, Izbicki J, Gagliani N, Flavell R, Huber S
NAT COMMUN. 2020;11(1):.

Microbiota-Dependent Effects of IL-22
Sabihi M, Böttcher M, Pelczar P, Huber S
CELLS-BASEL. 2020;9(10):2205.

The induction and function of the anti-inflammatory fate of TH17 cells
Xu H, Agalioti T, Zhao J, Steglich B, Wahib R, Vesely M, Bielecki P, Bailis W, Jackson R, Perez D, Izbicki J, Licona-Limón P, Kaartinen V, Geginat J, Esplugues E, Tolosa E, Huber S, Flavell R, Gagliani N
NAT COMMUN. 2020;11(1):3334.

A prenatally disrupted airway epithelium orchestrates the fetal origin of asthma in mice
Zazara-Giannou D, Wegmann M, Giannou A, Hierweger A, Alawi M, Thiele K, Huber S, Pincus M, Muntau A, Solano M, Arck P
J ALLERGY CLIN IMMUN. 2020;145(6):1641-1654.

IL-10-producing T cells and their dual functions
Bedke T, Muscate F, Soukou S, Gagliani N, Huber S
SEMIN IMMUNOL. 2019;44:101335.

Endogenous IL-22 is dispensable for experimental glomerulonephritis
Gnirck A, Wunderlich M, Becker M, Xiong T, Weinert E, Meyer-Schwesinger C, Dumoutier L, Renauld J, Huber S, Panzer U, Turner J
AM J PHYSIOL-RENAL. 2019;316(4):F712-F722.

Interferon-γ-dependent immune responses contribute to the pathogenesis of sclerosing cholangitis in mice
Ravichandran G, Neumann K, Berkhout L, Weidemann S, Langeneckert A, Schwinge D, Poch T, Huber S, Schiller B, Hess L, Ziegler A, Oldhafer K, Barikbin R, Schramm C, Altfeld M, Tiegs G
J HEPATOL. 2019;71(4):773-782.

Dendritic Cell Accumulation in the Gut and Central Nervous System Is Differentially Dependent on α4 Integrins
Sie C, Perez L, Kreutzfeldt M, Potthast M, Ohnmacht C, Merkler D, Huber S, Krug A, Korn T
J IMMUNOL. 2019;203(6):1417-1427.

Dietary Habits and Intestinal Immunity: From Food Intake to CD4(+) T-H Cells
Siracusa F, Schaltenberg N, Villablanca E, Huber S, Gagliani N
FRONT IMMUNOL. 2019;9:3177.

Comparison of the integrin α4β7 expression pattern of memory T cell subsets in HIV infection and ulcerative colitis
Wittner M, Schlicker V, Libera J, Bockmann J, Horvatits T, Seiz O, Kummer S, Manthey C, Hüfner A, Kantowski M, Rösch T, Degen O, Huber S, Eberhard J, Schulze Zur Wiesch J
PLOS ONE. 2019;14(7):e0220008.

T17 cell plasticity: The role of dendritic cells and molecular mechanisms
Agalioti T, Villablanca E, Huber S, Gagliani N
J AUTOIMMUN. 2018;87:50-60.

Molecular and functional heterogeneity of IL-10-producing CD4+ T cells
Brockmann L, Soukou S, Steglich B, Czarnewski P, Zhao L, Wende S, Bedke T, Ergen C, Manthey C, Agalioti T, Geffken M, Seiz O, Parigi S, Sorini C, Geginat J, Fujio K, Jacobs T, Roesch T, Izbicki J, Lohse A, Flavell R, Krebs C, Gustafsson J, Antonson P, Roncarolo M, Villablanca E, Gagliani N, Huber S
NAT COMMUN. 2018;9(1):5457.

Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression
Calcinotto A, Brevi A, Chesi M, Ferrarese R, Garcia Perez L, Grioni M, Kumar S, Garbitt V, Sharik M, Henderson K, Tonon G, Tomura M, Miwa Y, Esplugues E, Flavell R, Huber S, Canducci F, Rajkumar V, Bergsagel P, Bellone M
NAT COMMUN. 2018;9:4832.

Interleukin-22-deficiency and microbiota contribute to the exacerbation of Toxoplasma gondii-induced intestinal inflammation
Couturier-Maillard A, Froux N, Piotet-Morin J, Michaudel C, Brault L, Le Bérichel J, Sénéchal A, Robinet P, Chenuet P, Jejou S, Dumoutier L, Renauld J, Iovanna J, Huber S, Quesniaux V, Sokol H, Ryffel B
MUCOSAL IMMUNOL. 2018;11(4):1181-1190.

IL-10 Receptor Signaling Empowers Regulatory T Cells to Control Th17 Responses and Protect from GN
Diefenhardt P, Nosko A, Kluger M, Richter J, Wegscheid C, Kobayashi Y, Tiegs G, Huber S, Flavell R, Stahl R, Steinmetz O
J AM SOC NEPHROL. 2018;29(7):1825-1837.

Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation
Emgård J, Kammoun H, García-Cassani B, Chesné J, Parigi S, Jacob J, Cheng H, Evren E, Das S, Czarnewski P, Sleiers N, Melo-Gonzalez F, Kvedaraite E, Svensson M, Scandella E, Hepworth M, Huber S, Ludewig B, Peduto L, Villablanca E, Veiga-Fernandes H, Pereira J, Flavell R, Willinger T
IMMUNITY. 2018;48(1):120-132.

Colitis Promotes a Pathological Condition of the Liver in the Absence of Foxp3 Regulatory T Cells
Mathies F, Steffens N, Kleinschmidt D, Stuhlmann F, Huber F, Roy U, Meyer T, Luetgehetmann M, von Petersdorff M, Seiz O, Herkel J, Schramm C, Flavell R, Gagliani N, Krebs C, Panzer U, Abdullah Z, Strowig T, Bedke T, Huber S
J IMMUNOL. 2018;201(12):3558-3568.

Flt3 ligand expands bona fide innate lymphoid cell precursors in vivo
Parigi S, Czarnewski P, Das S, Steeg C, Brockmann L, Fernandez-Gaitero S, Yman V, Forkel M, Höög C, Mjösberg J, Westerberg L, Färnert A, Huber S, Jacobs T, Villablanca E
SCI REP-UK. 2018;8(1):154.

Colitis Ulcerosa – Behandlung nach der aktuellen S3-Leitlinie
Reher D, Manthey C, Bläker M, Huber S
Hamb Ärztebl. 2018;(11):22-24.

Role of IL-10 Receptor Signaling in the Function of CD4+ T-Regulatory Type 1 cells: T-Cell Therapy in Patients with Inflammatory Bowel Disease
Soukou S, Brockmann L, Bedke T, Gagliani N, Flavell R, Huber S
CRIT REV IMMUNOL. 2018;38(5):415-431.

Regulation of IL-22BP in psoriasis
Voglis S, Moos S, Kloos L, Wanke F, Zayoud M, Pelczar P, Giannou A, Pezer S, Albers M, Luessi F, Huber S, Schäkel K, Kurschus F
SCI REP-UK. 2018;8:5085.

Recipe for IBD: can we use food to control inflammatory bowel disease
Witkowski M, Witkowski M, Gagliani N, Huber S
SEMIN IMMUNOPATHOL. 2018;40(2):145-156.

IL-33 modulates inflammatory brain injury but exacerbates systemic immunosuppression following ischemic stroke
Zhang S, Piepke M, Chu H, Broughton B, Shim R, Wong C, Lee S, Evans M, Vinh A, Sakkal S, Arumugam T, Magnus T, Huber S, Gelderblom M, Drummond G, Sobey C, Kim H
JCI INSIGHT. 2018;3(18):.

IL-10 Receptor Signaling Is Essential for TR1 Cell Function In Vivo
Brockmann L, Gagliani N, Steglich B, Giannou A, Kempski J, Pelczar P, Geffken M, Mfarrej B, Huber F, Herkel J, Wan Y, Esplugues E, Battaglia M, Krebs C, Flavell R, Huber S
J IMMUNOL. 2017;198(3):1130-1141.

Regulation of TH17 Cells and Associated Cytokines in Wound Healing, Tissue Regeneration, and Carcinogenesis
Brockmann L, Giannou A, Gagliani N, Huber S
INT J MOL SCI. 2017;18(5):.

Basic Aspects of T Helper Cell Differentiation
Gagliani N, Huber S
Methods Mol Biol. 2017;1514:19-30.

CD4+ T Helper Cell Plasticity in Infection, Inflammation, and Autoimmunity
Huber S, Gagliani N, O'Connor W, Geginat J, Caprioli F
MEDIAT INFLAMM. 2017;2017:7083153.

TH17 Cell and Epithelial Cell Crosstalk during Inflammatory Bowel Disease and Carcinogenesis
Kempski J, Brockmann L, Gagliani N, Huber S
FRONT IMMUNOL. 2017;8:1373.

A Protective Function of IL-22BP in Ischemia Reperfusion and Acetaminophen-Induced Liver Injury
Kleinschmidt D, Giannou A, McGee H, Kempski J, Steglich B, Huber F, Ernst T, Shiri A, Wegscheid C, Tasika E, Hübener P, Huber P, Bedke T, Steffens N, Agalioti T, Fuchs T, Noll J, Lotter H, Tiegs G, Lohse A, Axelrod J, Galun E, Flavell R, Gagliani N, Huber S
J IMMUNOL. 2017;199(12):4078-4090.

TH17 cells express ST2 and are controlled by the alarmin IL-33 in the small intestine
Pascual-Reguant A, Bayat Sarmadi J, Baumann C, Noster R, Cirera-Salinas D, Curato C, Pelczar P, Huber S, Zielinski C, Löhning M, Hauser A, Esplugues E
MUCOSAL IMMUNOL. 2017;10(6):1431-1442.

Distinct Microbial Communities Trigger Colitis Development upon Intestinal Barrier Damage via Innate or Adaptive Immune Cells
Roy U, Gálvez E, Iljazovic A, Lesker T, Błażejewski A, Pils M, Heise U, Huber S, Flavell R, Strowig T
CELL REP. 2017;21(4):994-1008.

Dysfunction of hepatic regulatory T cells in experimental sclerosing cholangitis is related with IL-12 signaling
Schwinge D, von Haxthausen F, Quaas A, Carambia A, Otto B, Glaser F, Höh B, Thiele N, Schoknecht T, Huber S, Steffens N, Lohse A, Herkel J, Schramm C
J HEPATOL. 2017;66(4):798-805.

Intestinal type 1 regulatory T cells migrate to periphery to suppress diabetogenic T cells and prevent diabetes development
Yu H, Gagliani N, Ishigame H, Huber S, Zhu S, Esplugues E, Herold K, Wen L, Flavell R
P NATL ACAD SCI USA. 2017;114(39):10443-10448.

Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney
Krebs C, Paust H, Krohn S, Koyro T, Brix S, Riedel J, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch C, Mittrücker H, Steinhoff U, Stockinger B, Perez L, Wenzel U, Janneck M, Steinmetz O, Gagliani N, Stahl R, Huber S, Turner J, Panzer U
IMMUNITY. 2016;45(5):1078-1092.

Plasticity of Th17 Cells in Autoimmune Kidney Diseases
Krebs C, Turner J, Paust H, Kapffer S, Koyro T, Krohn S, Ufer F, Friese M, Flavell R, Stockinger B, Steinmetz O, Stahl R, Huber S, Panzer U
J IMMUNOL. 2016;197(2):449-57.

IL-23 prevents IL-13-dependent tissue repair associated with Ly6C(lo) monocytes in Entamoeba histolytica-induced liver damage
Noll J, Helk E, Fehling H, Bernin H, Marggraff C, Jacobs T, Huber S, Pelczar P, Ernst T, Ittrich H, Otto B, Mittrücker H, Hölscher C, Tacke F, Bruchhaus I, Tannich E, Lotter H
J HEPATOL. 2016;64(5):1147-57.

A pathogenic role for T cell-derived IL-22BP in inflammatory bowel disease
Pelczar P, Witkowski M, Perez L, Kempski J, Hammel A, Brockmann L, Kleinschmidt D, Wende S, Haueis C, Bedke T, Krasemann S, Steurer S, Booth C, Busch C, König A, Rauch U, Benten D, Izbicki J, Rösch T, Lohse A, Strowig T, Gagliani N, Flavell R, Huber S
SCIENCE. 2016;354(6310):358-362.

IL-22 dampens the T cell response in experimental malaria
Sellau J, Alvarado C, Hoenow S, Mackroth M, Kleinschmidt D, Huber S, Jacobs T
SCI REP-UK. 2016;6:28058.

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice
Carambia A, Freund B, Schwinge D, Bruns O, Salmen S, Ittrich H, Reimer R, Heine M, Huber S, Waurisch C, Eychmüller A, Wraith D, Korn T, Nielsen P, Weller H, Schramm C, Lüth S, Lohse A, Heeren J, Herkel J
J HEPATOL. 2015;62(6):1349-1356.

Intestinal Regulatory CD4+ T cells
Gagliani N, Huber S, Flavell R
2015. Mucosal Immunology. Mestecky J, Strober W, Russell M, Cheroutre H, Lambrecht B, Kelsall B (Hrsg.). 4. Aufl. Academic Press, 777-785.

Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation
Gagliani N, Vesely M, Iseppon A, Brockmann L, Xu H, Palm N, de Zoete M, Licona-Limón P, Paiva R, Ching T, Weaver C, Zi X, Pan X, Fan R, Garmire L, Cotton M, Drier Y, Bernstein B, Geginat J, Stockinger B, Esplugues E, Huber S, Flavell R
NATURE. 2015;523(7559):221-5.

Der klinisch und wissenschaftlich tätige Arzt– aktueller Stand und Perspektiven
Huber S, Schramm C
Z GASTROENTEROL. 2015;53(2):137-8.

Prenatal Acetaminophen Affects Maternal Immune and Endocrine Adaptation to Pregnancy, Induces Placental Damage, and Impairs Fetal Development in Mice
Thiele K, Solano M, Huber S, Flavell R, Kessler T, Barikbin R, Jung R, Karimi K, Tiegs G, Arck P
AM J PATHOL. 2015;185(10):2805-2818.

TGF-β-dependent induction of CD4⁺CD25⁺Foxp3⁺ Tregs by liver sinusoidal endothelial cells
Carambia A, Freund B, Schwinge D, Heine M, Laschtowitz A, Huber S, Wraith D, Korn T, Schramm C, Lohse A, Heeren J, Herkel J
J HEPATOL. 2014;61(3):594-9.

The Fire Within: Microbes Inflame Tumors
Gagliani N, Hu B, Huber S, Elinav E, Flavell R
CELL. 2014;157(4):776-783.

Hepatocytes contribute to immune regulation in the liver by activation of the Notch signaling pathway in T cells
Burghardt S, Erhardt A, Claass B, Huber S, Adler G, Jacobs T, Chalaris A, Schmidt-Arras D, Rose-John S, Karimi K, Tiegs G
J IMMUNOL. 2013;191(11):5574-82.

Inhibition of inflammatory CD4 T cell activity by murine liver sinusoidal endothelial cells
Carambia A, Frenzel C, Bruns O, Schwinge D, Reimer R, Hohenberg H, Huber S, Tiegs G, Schramm C, Lohse A, Herkel J
J HEPATOL. 2013;58(1):112-8.

Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells.
Gagliani N, Magnani C, Huber S, Gianolini M, Pala M, Licona-Limon P, Guo B, Herbert D, Bulfone A, Trentini F, Clelia D, Bacchetta R, Andreani M, Brockmann L, Gregori S, Flavell R, Roncarolo M
NAT MED. 2013;19(6):739-746.

Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer.
Hu B, Elinav E, Huber S, Strowig T, Hao L, Hafemann A, Jin C, Eisenbarth S, Flavell R
P NATL ACAD SCI USA. 2013;110(24):9862-9867.

Innate immune cells in inflammation and cancer
Nowarski R, Gagliani N, Huber S, Flavell R
CANCER IMMUNOL RES. 2013;1(2):77-84.

Regulatory T Cell-Derived IL-10 Ameliorates Crescentic GN.
Ostmann A, Paust H, Panzer U, Wegscheid C, Kapffer S, Huber S, Flavell R, Erhardt A, Tiegs G
J AM SOC NEPHROL. 2013;24(6):930-942.

Balancing pro- and anti-inflammatory CD4+ T helper cells in the intestine
Gagliani N, Huber S
2012. Autoimmune Diseases - Contributing Factors, Specific Cases of Autoimmune Diseases, and Stem Cell and Other Therapies. Intech open Science: 51-76.

The Intestine: where amazing things happen.
Gagliani N, Huber S, Flavell R
CELL RES. 2012;22(2):277-279.

Life, death, and miracles: Th17 cells in the intestine.
Huber S, Gagliani N, Flavell R
EUR J IMMUNOL. 2012;42(9):2238-2245.

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine
Huber S, Gagliani N, Zenewicz L, Huber F, Bosurgi L, Hu B, Hedl M, Zhang W, O'Connor W, Murphy A, Valenzuela D, Yancopoulos G, Booth C, Cho J, Ouyang W, Abraham C, Flavell R
NATURE. 2012;491(7423):259-263.

Control of TH17 cells occurs in the small intestine.
Esplugues E, Huber S, Gagliani N, Hauser A, Town T, Wan Y, O'Connor W, Rongvaux A, Nico V, Haberman A, Iwakura Y, Kuchroo V, Kolls J, Bluestone J, Herold K, Flavell R
NATURE. 2011;475(7357):514-518.

Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner
Huber S, Gagliani N, Esplugues E, O'Connor W, Huber F, Chaudhry A, Kamanaka M, Kobayashi Y, Booth C, Rudensky A, Roncarolo M, Battaglia M, Flavell R
IMMUNITY. 2011;34(4):554-565.

Role of activin A in the induction of Foxp3+ and Foxp3- CD4+ regulatory T cells.
Huber S, Schramm C
CRIT REV IMMUNOL. 2011;31(1):53-60.

Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology.
Kamanaka M, Huber S, Zenewicz L, Gagliani N, Rathinam C, O'Connor W, Wan Y, Nakae S, Iwakura Y, Hao L, Flavell R
J EXP MED. 2011;208(5):1027-1040.

Chronic inflammatory IFN-γ signaling suppresses hepatocarcinogenesis in mice by sensitizing hepatocytes for apoptosis.
Lüth S, Schrader J, Zander S, Carambia A, Buchkremer J, Huber S, Reifenberg K, Yamamura K, Schirmacher P, Lohse A, Herkel J
CANCER RES. 2011;71(11):3763-3771.

The induction of mild hypothermia improves systolic function of the resuscitated porcine heart at no further sympathetic activation
Schwarzl M, Steendijk P, Huber S, Truschnig-Wilders M, Obermayer-Pietsch B, Maechler H, Pieske B, Post H
ACTA PHYSIOL. 2011;203(4):409-18.

Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4
Hu B, Elinav E, Huber S, Booth C, Strowig T, Jin C, Eisenbarth S, Flavell R
P NATL ACAD SCI USA. 2010.

Activin a promotes the TGF-beta-induced conversion of CD4+CD25- T cells into Foxp3+ induced regulatory T cells.
Huber S, Stahl F, Schrader J, Lüth S, Presser K, Carambia A, Flavell R, Werner S, Blessing M, Herkel J, Schramm C
J IMMUNOL. 2009;182(8):4633-4640.

P38 MAP kinase signaling is required for the conversion of CD4+CD25- T cells into iTreg.
Huber S, Schrader J, Fritz G, Presser K, Schmitt S, Waisman A, Lüth S, Blessing M, Herkel J, Schramm C
PLOS ONE. 2008;3(10):3302.

Ectopic expression of neural autoantigen in mouse liver suppresses experimental autoimmune neuroinflammation by inducing antigen-specific Tregs
Lüth S, Huber S, Schramm C, Buch T, Zander S, Stadelmann C, Brück W, Wraith D, Herkel J, Lohse A
J CLIN INVEST. 2008;118(10):3403-3410.

Coexpression of TGF-beta1 and IL-10 enables regulatory T cells to completely suppress airway hyperreactivity
Presser K, Schwinge D, Wegmann M, Huber S, Schmitt S, Quaas A, Maxeiner J, Finotto S, Lohse A, Blessing M, Schramm C
J IMMUNOL. 2008;181(11):7751-7758.

TGF-beta and CD4+CD25+ regulatory T cells
Huber S, Schramm C
FRONT BIOSCI-LANDMRK. 2006;11(1):1014-1023.

TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling
Becker C, Fantini M, Schramm C, Lehr H, Wirtz S, Nikolaev A, Burg J, Strand S, Kiesslich R, Huber S, Ito H, Nishimoto N, Yoshizaki K, Kishimoto T, Galle P, Blessing M, Rose-John S, Neurath M
IMMUNITY. 2004;21(4):491-501.

Cutting edge: TGF-beta signaling is required for the in vivo expansion and immunosuppressive capacity of regulatory CD4+CD25+ T cells
Huber S, Schramm C, Lehr H, Mann A, Schmitt S, Becker C, Protschka M, Galle P, Neurath M, Blessing M
J IMMUNOL. 2004;173(11):6526-31.

TGFbeta regulates the CD4+CD25+ T-cell pool and the expression of Foxp3 in vivo
Schramm C, Huber S, Protschka M, Czochra P, Burg J, Schmitt E, Lohse A, Galle P, Blessing M
INT IMMUNOL. 2004;16(9):1241-1249.

Susceptibility to collagen-induced arthritis is modulated by TGFbeta responsiveness of T cells
Schramm C, Kriegsmann J, Protschka M, Huber S, Hansen T, Schmitt E, Galle P, Blessing M
ARTHRITIS RES THER. 2004;6(2):R114-R119.

Letzte Aktualisierung aus dem FIS: 14.07.2025 - 00:51 Uhr