- Klinikdirektor
- Heisenberg-Professur für Intestinale Immunregulation
- Leiter der molekularen Gastroenterologie und Immunologie
- Facharzt für Innere Medizin und Gastroenterologie
Tätigkeitsschwerpunkte
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Chronisch entzündliche Darmerkrankungen
Lebenslauf
Auszeichnungen
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2017: Theodor-Frerichs-Preis der DGIM
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2017: Heisenberg Professur für Intestinale Immunregulation
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2013: DACED Zukunftspreis
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2013: Dr.-Liselotte-Brauns-Preis für die beste Klinische Forschungsarbeit im Fachbereich Innere Medizin
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2012: Ernst Jung-Karriere-Förder-Preis für medizinische Forschung
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2012: Peter Hans Hofschneider Stiftungsprofessur
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2010: Postdoctoral Fellowship award der „Crohn's and Colitis Foundation of America“
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2009: Dr. Martini-Preis (geteilt mit Dr. S. Lüth)
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2009: James Hudson Brown - Alexander Brown Coxe Postdoctoral Fellowship award
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2006: Johannes Gutenberg Promotionspreis
Mitgliedschaften
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DGVS
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DGIM
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ECCO
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DACED
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Kompetenznetz Darmerkrankung e.V.
Publikationen
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Brockmann, L., Soukou, S., Steglich, B., Czarnewski, P., Zhao, L., Wende, S., Bedke, T., Ergen, C., Manthey, C., Agalioti, T., Geffken, M., Seiz, O., Parigi, S. M., Sorini, S., Geginat, J., Fujio, K., Jacobs, T., Roesch, T., Izbicki, J. R., Lohse, W. W., Flavell, R. A., Krebs, C., Gustafsson, J. A., Antonson, P., Roncarolo, M. G., Villablanca, E. J., Gagliani, N.*, and Huber, S.* (2018) Molecular and functional heterogeneity of IL-10-producing CD4(+) T cells. Nature communications 9: 5457.
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Brockmann, L., Gagliani, N., Steglich, B., Giannou, A.D., Kempski, J., Pelczar, P., Geffken, M., Mfarrej, B., Huber, F., Herkel, J., Wan, Y.Y., Esplugues, E., Battaglia, M., Krebs, C.F., Flavell, R.A.*, and Huber, S.* (*equally contributing senior authors). (2017) IL-10 Receptor Signaling Is Essential for TR1 Cell Function In Vivo. J Immunol. 198, 1130-1141
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Pelczar, P., Witkowski, M., Perez, L.G., Kempski, J., Hammel, A.G., Brockmann, L., Kleinschmidt, D., Wende, S., Haueis, C., Bedke, T., Witkowski, M., Krasemann, S., Steurer, S., Booth, C.J., Busch, P., Konig, A., Rauch, U., Benten, D., Izbicki, J.R., Rosch, T., Lohse, A.W., Strowig, T., Gagliani, N., Flavell, R.A.*, and Huber, S.* (*equally contributing senior authors). (2016) A pathogenic role for T cell-derived IL-22BP in inflammatory bowel disease. Science 354, 358-362.
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Gagliani, N., M. C. Vesely, A. Iseppon, L. Brockmann, H. Xu, N. W. Palm, M. R. de Zoete, P. Licona-Limon, R. S. Paiva, T. Ching, C. Weaver, X. Zi, X. Pan, R. Fan, L. X. Garmire, M. J. Cotton, Y. Drier, B. Bernstein, J. Geginat, B. Stockinger, E. Esplugues, S. Huber*, and R. A. Flavell* (*equally contributing senior authors). (2015). Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation. Nature 523, 221-225
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Gagliani, N.*, Magnani, C.F.*, Huber, S.* (*equally contributing authors), Gianolini, M.E., Pala, M., Licona-Limon, P., Guo, B., Herbert, D.R., Bulfone, A., Trentini, F., Di Serio, C., Bacchetta, R., Andreani, M., Brockmann, L., Gregori, S., Flavell, R. A., Roncarolo, M. G. (2013). Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells. Nat Med. 19, 739-46.
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Huber, S.*, Gagliani, N.* (*equally contributing authors), Zenewicz, L.A., Huber, F.J., Bosurgi, L., Hu, B., Hedl, M., Zhang, W., O’Connor, W., Murphy, A.J., Valenzuela, D.M., Yancopoulos, G.D., Booth, C.J. Cho, J.H., Ouyang, W., Abraham, C., and Flavell, R.A. (2012). IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature 491, 259-263. (S.H and R.A.F. are co-corresponding authors)
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Esplugues, E.*, Huber, S.* (*equally contributing authors), Gagliani, N., Hauser, A.E., Town, T., Wan, Y.Y., O'Connor, W., Jr., Rongvaux, A., Van Rooijen, N., Haberman, A.M., Iwakura, Y., Kuchroo, V.K., Kolls, J.K., Bluestone, J.A., Herold, K.C., and Flavell, R.A. (2011). Control of TH17 cells occurs in the small intestine. Nature 475, 514-518.
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Huber, S.*, Gagliani, N.*, Esplugues, E.* (*equally contributing authors), O'Connor, W., Jr., Huber, F.J., Chaudhry, A., Kamanaka, M., Kobayashi, Y., Booth, C.J., Rudensky, A.Y., Roncarolo, M.G., Battaglia, M., and Flavell, R.A. (2011). Th17 cells express interleukin-10 receptor and are controlled by Foxp3 and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner. Immunity 34, 554-565.
