• Nucleotide-Induced Membrane-Proximal Proteolysis Controls the Substrate Specificity of T Cell Ecto-ADP-Ribosyltransferase ARTC2.2. Menzel S, Rissiek B, Bannas P, Jakoby T, Miksiewicz M, Schwarz N, Nissen M, Haag F, Tholey A, Koch-Nolte F. J Immunol. 2015 Jul 24. pii: 1401677. [Epub ahead of print] PMID:26209623

    P2X7 on Mouse T Cells: One Channel, Many Functions. Rissiek B, Haag F, Boyer O,Koch-Nolte F, Adriouch S. Front Immunol. 2015 May 19;6:204. doi: 10.3389/fimmu.2015.00204. eCollection 2015. Review. PMID:26042119

    TH1 and TH17 cells promote crescent formation in experimental autoimmune glomerulonephritis. Hünemörder S, Treder J, Ahrens S, Schumacher V, Paust HJ, Menter T, Matthys P, Kamradt T, Meyer-Schwesinger C, Panzer U, Hopfer H,Mittrücker HW. J Pathol. 2015 May 12. doi: 10.1002/path.4559. [Epub ahead of print]

    CD38 is expressed on inflammatory cells of the intestine and promotes intestinal inflammation. Schneider M, Schumacher V, Lischke T, Lücke K, Meyer-Schwesinger C, Velden J, Koch-Nolte F, Mittrücker HW. PLoS One. 2015 May 4;10(5):e0126007. doi: 10.1371/journal.pone.0126007. eCollection 2015. PMID:25938500

    Molecular imaging of tumors with nanobodies and antibodies: Timing and dosage are crucial factors for improved in vivo detection. Bannas P, Lenz A, Kunick V, Well L, Fumey W, Rissiek B, Haag F, Schmid J, Schütze K, Eichhoff A, Trepel M, Adam G, Ittrich H, Koch-Nolte F. Contrast Media Mol Imaging. 2015 Apr 27. doi: 10.1002/cmmi.1637. [Epub ahead of print]

    Validation of nanobody and antibody based in vivo tumor xenograft NIRF-imaging experiments in mice using ex vivo flow cytometry and microscopy. Bannas P, Lenz A, Kunick V, Fumey W, Rissiek B, Schmid J, Haag F, Leingärtner A, Trepel M, Adam G,Koch-Nolte F. J Vis Exp. 2015 Apr 6;(98):e52462. doi: 10.3791/52462. PMID:25867711

    Glomerulopathy induced by immunization with a peptide derived from the goodpasture antigen #3IV-NC1. Hopfer H, Hünemörder S, Treder J, Turner JE, Paust HJ, Meyer-Schwesinger C, Hopfer U, Sachs M, Peters A, Bucher-Kocaoglu B, Ahrens S, Panzer U, Mittrücker HW. J Immunol. 2015 Apr 15;194(8):3646-55. doi: 10.4049/jimmunol.1401267. Epub 2015 Mar 13

    Tuning IL-2 signaling by ADP-ribosylation of CD25. Teege S, Hann A, Miksiewicz M, MacMillan C, Rissiek B, Buck F, Menzel S, Nissen M, Bannas P, Haag F, Boyer O, Seman M, Adriouch S, Koch-Nolte F. Sci Rep. 2015 Mar 10;5:8959. doi: 10.1038/srep08959. PMID:25753532

    Inflammation-Induced IL-6 Functions as a Natural Brake on Macrophages and Limits GN. Luig M, Kluger MA, Goerke B, Meyer M, Nosko A, Yan I, Scheller J, Mittrücker HW, Rose-John S, Stahl RA, Panzer U, Steinmetz OM. J Am Soc Nephrol. 2015 Jul;26(7):1597-607. doi: 10.1681/ASN.2014060620. Epub 2015 Feb 5.

    The expression of CD39 on regulatory T cells is genetically driven and further upregulated at sites of inflammation. Rissiek A, Baumann I, Cuapio A, Mautner A, Kolster M, Arck PC, Dodge-Khatami A, Mittrücker HW, Koch-Nolte F, Haag F, Tolosa E. J Autoimmun. 2015 Apr;58:12-20. doi: 10.1016/j.jaut.2014.12.007. Epub 2015 Jan 29. PMID:25640206

    Blockade of P2X7 receptors or pannexin-1 channels similarly attenuates postischemic damage. Cisneros-Mejorado A, Gottlieb M, Cavaliere F, Magnus T, Koch-Nolte F, Scemes E, Pérez-Samartín A, Matute C. J Cereb Blood Flow Metab. 2015 May;35(5):843-50. doi: 10.1038/jcbfm.2014.262. Epub 2015 Jan 21. PMID:25605289

    Mannose 6 phosphorylation of lysosomal enzymes controls B cell functions. Otomo T, Schweizer M, Kollmann K, Schumacher V, Muschol N, Tolosa E, Mittrücker HW, Braulke T. J Cell Biol. 2015 Jan 19;208(2):171-80. doi: 10.1083/jcb.201407077. PMID:25601403

    Selection of nanobodies that block the enzymatic and cytotoxic activities of the binary Clostridium difficile toxin CDT. Unger M, Eichhoff AM, Schumacher L, Strysio M, Menzel S, Schwan C, Alzogaray V, Zylberman V, Seman M, Brandner J, Rohde H, Zhu K, Haag F, Mittrücker HW, Goldbaum F, Aktories K, Koch-Nolte F. Sci Rep. 2015 Jan 19;5:7850. doi: 10.1038/srep07850. PMID:25597743

  • Nanobodies as modulators of inflammation: potential applications for acute brain injury. Rissiek B, Koch-Nolte F, Magnus T. Front Cell Neurosci. 2014 Oct 21;8:344. doi: 10.3389/fncel.2014.00344. eCollection 2014. PMID:25374510

    Multidimensional scaling analysis identifies pathological and prognostically relevant profiles of circulating Tcells in chronic lymphocytic leukemia. Rissiek A, Schulze C, Bacher U, Schieferdecker A, Thiele B, Jacholkowski A, Flammiger A, Horn C, Haag F, Tiegs G, Zirlik K, Trepel M, Tolosa E, Binder M.. Int J Cancer. 2014 Nov 15;135(10):2370-9. PMID: 24723150

    ARTC1-mediated ADP-ribosylation of GRP78/BiP: a new player in endoplasmic-reticulum stress responses. Fabrizio G, Di Paola S, Stilla A, Giannotta M, Ruggiero C, Menzel S, Koch-Nolte F, Sallese M, Di Girolamo M. Cell Mol Life Sci. 2015 Mar;72(6):1209-25. doi: 10.1007/s00018-014-1745-6. Epub 2014 Oct 8. PMID:25292337Advancing the detection of maternal haematopoietic microchimeric cells in fetal immune organs in mice by flow cytometry. Solano ME, Thiele K, Stelzer IA, Mittrücker HW, Arck PC. Chimerism. 2014 Oct 30:1-4. [Epub ahead of print]

    CXCL5 Drives Neutrophil Recruitment in TH17-Mediated GN. Disteldorf EM, Krebs CF, Paust HJ, Turner JE, Nouailles G, Tittel A, Meyer-Schwesinger C, Stege G, Brix S, Velden J, Wiech T, Helmchen U, Steinmetz OM, Peters A, Bennstein SB, Kaffke A, Llanto C, Lira SA, Mittrücker HW, Stahl RA, Kurts C, Kaufmann SH, Panzer U.J Am Soc Nephrol. 2014 Jun 5. pii: ASN.2013101061. [Epub ahead of print] PMID:24904089

    Heterogeneity in the Differentiation and Function of CD8+ T Cells. Mittrücker HW, Visekruna A, Huber M.Arch Immunol Ther Exp (Warsz). 2014 May 31. [Epub ahead of print] PMID:24879097

    ADP-Ribosylation of P2X7: A Matter of Life and Death for Regulatory T Cells and Natural Killer T Cells. Rissiek B, Haag F, Boyer O, Koch-Nolte F, Adriouch S.Curr Top Microbiol Immunol. 2014 Jul 22. [Epub ahead of print] PMID:25048544

    In vivo near-infrared fluorescence targeting of T cells: comparison of nanobodies and conventional monoclonal antibodies.Bannas P, Well L, Lenz A, Rissiek B, Haag F, Schmid J, Hochgräfe K, Trepel M, Adam G, Ittrich H, Koch-Nolte F.Contrast Media Mol Imaging. 2014 Mar-Apr;9(2):135-42. doi: 10.1002/cmmi.1548.PMID:24523058

    The function of the chemokine receptor CXCR6 in the T cell response of mice against Listeria monocytogenes.Heesch K, Raczkowski F, Schumacher V, Hünemörder S, Panzer U, Mittrücker HW. PLoS One. 2014 May 15;9(5):e97701.PMID:24832098

    IRF4 and BATF are critical for CD8b T-cell function following infection with LCMV.Grusdat M, McIlwain DR, Xu HC, Pozdeev VI, Knievel J, Crome SQ, Robert-Tissot C, Dress RJ, Pandyra AA, Speiser DE, Lang E, Maney SK, Elford AR, Hamilton SR, Scheu S, Pfeffer K, Bode J, Mittrücker HW, Lohoff M, Huber M, Häussinger D, Ohashi PS, Mak TW, Lang KS, Lang PA. Cell Death Differ. 2014 Jul;21(7):1050-60. Epub 2014 Feb 14.PMID:24531538

    Stat3 programs Th17-specific regulatory T cells to control GN.Kluger MA, Luig M, Wegscheid C, Goerke B, Paust HJ, Brix SR, Yan I, Mittrücker HW, Hagl B, Renner ED, Tiegs G, Wiech T, Stahl RA, Panzer U, Steinmetz OM.J Am Soc Nephrol. 2014 Jun;25(6):1291-302. Epub 2014 Feb 7.PMID:24511136

    Clostridium difficile toxin CDT hijacks microtubule organization and reroutes vesicle traffic to increase pathogen adherence.Schwan C, Kruppke AS, Nölke T, Schumacher L, Koch-Nolte F, Kudryashev M, Stahlberg H, Aktories K.Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2313-8. Epub 2014 Jan 27.PMID:24469807

    Lack of microbiota reduces innate responses and enhances adaptive immunity against Listeria monocytogenes infection. Mittrücker HW, Seidel D, Bland PW, Zarzycka A, Kaufmann SH, Visekruna A, Steinhoff U.Eur J Immunol. 2014 Jun;44(6):1710-5. Epub 2014 Mar 20.PMID:24643764

    CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis.Nouailles G, Dorhoi A, Koch M, Zerrahn J, Weiner J 3rd, Faé KC, Arrey F, Kuhlmann S, Bandermann S, Loewe D, Mollenkopf HJ, Vogelzang A, Meyer-Schwesinger C, Mittrücker HW, McEwen G, Kaufmann SH.J Clin Invest. 2014 Mar 3;124(3):1268-82. Epub 2014 Feb 10.PMID:24509076

    Evidence of promiscuous endothelial binding by Plasmodium falciparum-infected erythrocytes.Esser C, Bachmann A, Kuhn D, Schuldt K, Förster B, Thiel M, May J,Koch-Nolte F, Yáñez-Mó M, Sánchez-Madrid F, Schinkel AH, Jalkanen S, Craig AG, Bruchhaus I, Horstmann RD.Cell Microbiol. 2014 May;16(5):701-8. Epub 2014 Feb 24.PMID:24444337

    Mucolipidosis II-related mutations inhibit the exit from the endoplasmic reticulum and proteolytic cleavage of GlcNAc-1-phosphotransferase precursor protein (GNPTAB).De Pace R, Coutinho MF, Koch-Nolte F, Haag F, Prata MJ, Alves S, Braulke T, Pohl S.Hum Mutat. 2014 Mar;35(3):368-76. Epub 2014 Jan 15.PMID:24375680

    Technical Advance: a new cell preparation strategy that greatly improves the yield of vital and functional Tregs and NKT cells.Rissiek B, Danquah W, Haag F, Koch-Nolte F.J Leukoc Biol. 2014 Mar;95(3):543-9. Epub 2013 Nov 8.PMID:24212099

    Identification and Analysis of ADP-Ribosylated Proteins. Haag F, Buck F.Curr Top Microbiol Immunol. 2014 Aug 12. [Epub ahead of print] PMID:25113886

    Functional autoantibodies against SSX-2 and NY-ESO-1 in multiple myeloma patients after allogeneic stem cell transplantation.Luetkens T, Kobold S, Cao Y, Ristic M, Schilling G, Tams S, Bartels BM, Templin J, Bartels K, Hildebrandt Y, Yousef S, Marx A, Haag F, Bokemeyer C, Kröger N, Atanackovic D.Cancer Immunol Immunother. 2014 Jul 31. [Epub ahead of print] PMID:25078248

    CD4+ T-cell help is required for effective CD8+ T cell-mediated resolution of acute viral hepatitis in mice.Trautmann T, Kozik JH, Carambia A, Richter K, Lischke T, Schwinge D, Mittrücker HW, Lohse AW, Oxenius A, Wiegard C, Herkel J.PLoS One. 2014 Jan 21;9(1):e86348. PMID:24466045

    Immune activation in amyloid-#-related angiitis correlates with decreased parenchymal amyloid-# plaque load. Bogner S, Bernreuther C, Matschke J, Barrera-Ocampo A, Sepulveda-Falla D, Leypoldt F, Magnus T, Haag F, Bergmann M, Brück W, Vogelgesang S, Glatzel M.Neurodegener Dis. 2014;13(1):38-44. Epub 2013 Sep 6.PMID:24021982

  • Effect of prenatal steroid treatment on the developing immune system. Diepenbruck I, Much CC, Krumbholz A, Kolster M, Thieme R, Thieme D, Solano ME, Arck PC, Tolosa E. J Mol Med (Berl). 2013; 91:1293-1302. PMID: 23851605

    Immune activation in amyloid-#-related angiitis correlates with decreased parenchymal amyloid-# plaque load. Bogner S, Bernreuther C, Matschke J, Barrera-Ocampo A, Sepulveda-Falla D, Leypoldt F, Magnus T, Haag F, Bergmann M, Brück W, Vogelgesang S, Glatzel M.Neurodegener Dis. 2014;13(1):38-44. Epub 2013 Sep 6.PMID:24021982

    Exploring the basis of central tolerance: what do dendritic cells pre-sent in the human thymus? Adamopoulou E, Tenzer S, Hillen N, Quecke P, Tietz S, Gebhardt M, Stevanovic S, Rammensee H-G, Tolosa E, Melms A, Stoeckle C. Nature Communications 2013; 4:2039. PMID: 23783831

    Fine mapping and functional analysis of the multiple sclerosis risk gene CD6.Swaminathan B, Cuapio A, Alloza I, Matesanz F, Alcina A, García-Barcina M, Fedetz M, Fernández O, Izquierdo I, Órpez T, Pinto-Medel MJ, Otaegui D, Olascoaga J, Urcelay E, Ortiz MA, Arroyo R, Oksen-berg JR, Antigüedad A, Tolosa E, Vandenbroeck K. PLoS One 2013 Apr 24;8(4):e62376. PMID: 23638056

    Relapsing cerebral aspergilloma associated with pregnancy. Kruetzelmann A, Sobottka I, Fiehler J, Tolosa E, Gerloff C, Rosenkranz M. Clin Neurol & Neurosurg. 2013; 115: 1154-1156. PMID: 23058744

    Short-term TNF# shedding is independent of cytoplasmic phosphorylation or furin cleavage of ADAM17. Schwarz J, Broder C, Helmstetter A, Schmidt S, Yan I, Müller M, Schmidt-Arras D, Becker-Pauly C, Koch-Nolte F, Mittrücker HW, Rabe B, Rose-John S, Chalaris A. Biochim Biophys Acta. 2013 Dec;1833(12):3355-67. Epub 2013 Oct 14. PMID:24135057

    Peripheral blood biomarkers for the characterization of alloimmune reactivity after pediatric liver transplantation. Briem-Richter A, Leuschner A, Krieger T, Grabhorn E, Fischer L, Nashan B, Haag F,
    Ganschow R. Pediatr Transplant. 2013 Dec;17(8):757-64. doi: 10.1111/petr.12161. Epub 2013 Oct 6. PMID: 24164827

    CD38 controls the innate immune response against Listeria monocytogenes. Lischke T, Heesch K, Schumacher V, Schneider M, Haag F, Koch-Nolte F, Mittrücker HW. Infect Immun. 2013 Nov;81(11):4091-9. Epub 2013 Aug 26. PMID: 23980105

    Isolation of myeloid dendritic cells and epithelial cells from human thymus. Stoeckle C, Rota IA, Tolosa E, Haller C, Melms A, Adamopoulou E. J Vis Exp. 2013 Sep 19;(79):e50951. PMID: 24084687

    The transcription factor Interferon Regulatory Factor 4 is required for the generation of protective effector CD8+ T cells. Raczkowski F, Ritter J, Heesch K, Schumacher V, Guralnik A, Höcker L, Raifer H, Klein M, Bopp T, Harb H, Kesper DA, Pfefferle PI, Grusdat M, Lang PA, Mittrücker HW, Huber M. Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15019-24. Epub 2013 Aug 26. PMID: 23980171

    Physiology of ADP-ribosylation. Koch-Nolte F, Ziegler M. FEBS J. 2013 Aug;280(15):3483. Epub 2013 Jul 12. PMID: 23773547

    The art of blocking ARTs: Nanobodies as experimental and therapeutic tools to block mammalian and toxin ADP-ribosyltransferases. Menzel S, Rissiek B, Haag F, Goldbaum F, Koch-Nolte F. FEBS J. 2013 Apr 29. doi: 10.1111/febs.12313. [Epub ahead of print] PMID: 23627412

    CD8b ADP-ribosylation affects CD8+ T-cell function. Lischke T, Schumacher V, Wesolowski J, Hurwitz R, Haag F, Koch-Nolte F, Mittrücker HW. Eur J Immunol. 2013 Apr 11. doi: 10.1002/eji.201243231. [Epub ahead of print] PMID: 23575529

    IL-6 controls the innate immune response against Listeria monocytogenes via classical IL-6 signaling. Hoge J, Yan I, Jänner N, Schumacher V, Chalaris A, Steinmetz OM, Engel DR, Scheller J, Rose-John S, Mittrücker HW. J Immunol. 2013 Jan 15;190(2):703-11. doi: 10.4049/jimmunol.1201044. Epub 2012 Dec 12.PMID: 23241882

    IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis. Huber M, Heink S, Pagenstecher A, Reinhard K, Ritter J, Visekruna A, Guralnik A, Bollig N, Jeltsch K, Heinemann C, Wittmann E, Buch T, Prazeres da Costa O, Brüstle A, Brenner D, Mak TW, Mittrücker HW, Tackenberg B, Kamradt T, Lohoff M. J Clin Invest. 2013 Jan 2;123(1):247-60. doi: 10.1172/JCI63681. Epub 2012 Dec 10. PMID: 23221338

  • Alternative splicing of the N-terminal cytosolic and transmembrane domains of P2X7 controls gating of the ion channel by ADP-ribosylation. Schwarz N, Drouot L, Nicke A, Fliegert R, Boyer O, Guse AH, Haag F, Adriouch S, Koch-Nolte F. PLoS One. 2012;7(7):e41269. doi: 10.1371/journal.pone.0041269. Epub 2012 Jul 27. PMID: 22848454

    Extracellular NAD(+): a danger signal hindering regulatory T cells. Adriouch S, Haag F, Boyer O, Seman M, Koch-Nolte F. Microbes Infect. 2012 Nov;14(14):1284-92. doi: 10.1016/j.micinf.2012.05.011. Epub 2012 May 24. PMID: 22634347

    Melittin modulates keratinocyte function through P2 receptor-dependent ADAM activation. Sommer A, Fries A, Cornelsen I, Speck N, Koch-Nolte F, Gimpl G, Andrä J, Bhakdi S, Reiss K. J Biol Chem. 2012 Jul 6;287(28):23678-89. doi: 10.1074/jbc.M112.362756. Epub 2012 May 21. PMID: 22613720

    Renal IL-17 expression in human ANCA-associated glomerulonephritis. Velden J, Paust HJ, Hoxha E, Turner JE, Steinmetz OM, Wolf G, Jabs WJ, Özcan F, Beige J, Heering PJ, Schröder S, Kneißler U, Disteldorf E, Mittrücker HW, Stahl RA, Helmchen U, Panzer U. Am J Physiol Renal Physiol. 2012 Jun 15;302(12):F1663-73. doi: 10.1152/ajprenal.00683.2011. Epub 2012 Mar 21. PMID: 22442208

    Characterization of the renal CD4+ T-cell response in experimental autoimmune glomerulonephritis. Hopfer H, Holzer J, Hünemörder S, Paust HJ, Sachs M, Meyer-Schwesinger C, Turner JE, Panzer U, Mittrücker HW. Kidney Int. 2012 Jul;82(1):60-71. doi: 10.1038/ki.2012.73. Epub 2012 Mar 21. PMID: 2243741

    Immature renal dendritic cells recruit regulatory CXCR6(+) invariant natural killer T cells to attenuate crescentic GN. Riedel JH, Paust HJ, Turner JE, Tittel AP, Krebs C, Disteldorf E, Wegscheid C, Tiegs G, Velden J, Mittrücker HW, Garbi N, Stahl RA, Steinmetz OM, Kurts C, Panzer U. J Am Soc Nephrol. 2012 Dec;23(12):1987-2000. doi: 10.1681/ASN.2012040394. Epub 2012 Nov 8. PMID: 23138484

    Chemokines play a critical role in the cross-regulation of Th1 and Th17 immune responses in murine crescentic glomerulonephritis. Paust HJ, Turner JE, Riedel JH, Disteldorf E, Peters A, Schmidt T, Krebs C, Velden J, Mittrücker HW, Steinmetz OM, Stahl RA, Panzer U. Kidney Int. 2012 Jul;82(1):72-83. doi: 10.1038/ki.2012.101. Epub 2012 Apr 11. PMID: 22495297

    IFN-# production by allogeneic Foxp3+ regulatory T cells is essential for preventing experimental graft-versus-host disease. Koenecke C, Lee CW, Thamm K, Föhse L, Schafferus M, Mittrücker HW, Floess S, Huehn J, Ganser A, Förster R, Prinz I. J Immunol. 2012 Sep 15;189(6):2890-6. doi: 10.4049/jimmunol.1200413. Epub 2012 Aug 6. PMID: 22869903

    The sorting receptor Sortilin exhibits a dual function in exocytic trafficking of interferon-# and granzyme A in T cells. Herda S, Raczkowski F, Mittrücker HW, Willimsky G, Gerlach K, Kühl AA, Breiderhoff T, Willnow TE, Dörken B, Höpken UE, Rehm A. Immunity. 2012 Nov 16;37(5):854-66. doi: 10.1016/j.immuni.2012.07.012. Epub 2012 Oct 16. PMID: 23084031

    Relapsing cerebral aspergilloma associated with pregnancy. Kruetzelmann A, Sobottka I, Fiehler J, Tolosa E, Gerloff C, Rosenkranz M. Clin Neurol Neurosurg. 2013 Jul;115(7):1154-6. doi: 10.1016/j.clineuro.2012.09.024. Epub 2012 Oct 8. No abstract available. PMID: 23058744

    Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke. Gelderblom M, Weymar A, Bernreuther C, Velden J, Arunachalam P, Steinbach K, Orthey E, Arumugam TV, Leypoldt F, Simova O, Thom V, Friese MA, Prinz I, Hölscher C, Glatzel M, Korn T, Gerloff C, Tolosa E, Magnus T. Blood. 2012 Nov 1;120(18):3793-802. doi: 10.1182/blood-2012-02-412726. Epub 2012 Sep 13. PMID: 22976954

  • Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail. Behnke J, Schneppenheim J, Koch-Nolte F, Haag F, Saftig P, Schröder B. FEBS Lett. 2011 Oct 3;585(19):2951-7. Epub 2011 Sep 2. PMID: 21896273

    Monoclonal antibodies for the identification and purification of vNAR domains and IgNAR immunoglobulins from the horn shark Heterodontus francisci. Juarez K, Dubberke G, Lugo P, Koch-Nolte F, Buck F, Haag F, Licea A. Hybridoma (Larchmt). 2011 Aug;30(4):323-9. PMID: 21851231

    Transgenic overexpression of toxin-related ecto-ADP-ribosyltransferase ART2.2 sensitizes T cells but not B cells to NAD-induced cell death. Bannas P, Scheuplein F, Well L, Hermans-Borgmeyer I, Haag F, Koch-Nolte F. Mol Immunol. 2011 Sep;48(15-16):1762-70. PMID: 21641039

    Strategies for the identification of arginine ADP-ribosylation sites. Laing S, Koch-Nolte F, Haag F, Buck F. J Proteomics. 2011 Dec 10;75(1):169-76. doi: 10.1016/j.jprot.2011.07.003. Epub 2011 Jul 19. PMID: 21784185

    CD38 exacerbates focal cytokine production, postischemic inflammation and brain injury after focal cerebral ischemia. Choe CU, Lardong K, Gelderblom M, Ludewig P, Leypoldt F, Koch-Nolte F, Gerloff C, Magnus T. PLoS One. 2011;6(5):e19046. Epub 2011 May 13. PMID: 21625615

    Progress in the function and regulation of ADP-Ribosylation. Hottiger MO, Boothby M,Koch-Nolte F, Lüscher B, Martin NM, Plummer R, Wang ZQ, Ziegler M. Sci Signal. 2011 May 24;4(174):mr5. doi: 10.1126/scisignal.2001645. PMID: 21610250

    Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding. Garbers C, Jänner N, Chalaris A, Moss ML, Floss DM, Meyer D, Koch-Nolte F, Rose-John S, Scheller J. J Biol Chem. 2011 Apr 29;286(17):14804-11. Epub 2011 Mar 15. PMID: 21454673

    Compartmentation of NAD+-dependent signalling. Koch-Nolte F, Fischer S, Haag F, Ziegler M. FEBS Lett. 2011 Jun 6;585(11):1651-6. Epub 2011 Mar 31. Review. PMID: 21443875

    Single-domain llama antibodies as specific intracellular inhibitors of SpvB, the actin ADP-ribosylating toxin of Salmonella typhimurium. Alzogaray V, Danquah W, Aguirre A, Urrutia M, Berguer P, García Véscovi E, Haag F, Koch-Nolte F, Goldbaum FA. FASEB J. 2011 Feb;25(2):526-34. Epub 2010 Oct 12. PMID: 20940265

    ADP-ribosylation of arginine. Laing S, Unger M, Koch-Nolte F, Haag F. Amino Acids. 2011 Jul;41(2):257-69. Epub 2010 Jul 21. Review. PMID: 20652610

    Characterisation of a novel glycosylphosphatidylinositol-anchored mono-ADP-ribosyltransferase isoform in ovary cells. Stilla A, Di Paola S, Dani N, Krebs C, Arrizza A, Corda D, Haag F, Koch-Nolte F, Di Girolamo M. Eur J Cell Biol. 2011 Aug;90(8):665-77. doi: 10.1016/j.ejcb.2011.03.007. Epub 2011 May 26. PMID: 21616557

    CXCR3 deficiency exacerbates liver disease and abrogates tolerance in a mouse model of immune-mediated hepatitis. Erhardt A, Wegscheid C, Claass B, Carambia A, Herkel J, Mittrücker HW, Panzer U, Tiegs G. J Immunol. 2011 May 1;186(9):5284-93. Epub 2011 Mar 25. PMID: 21441449

    Regulatory T cells control the Th1 immune response in murine crescentic glomerulonephritis. Paust HJ, Ostmann A, Erhardt A, Turner JE, Velden J, Mittrücker HW, Sparwasser T, Panzer U, Tiegs G. Kidney Int. 2011 Jul;80(2):154-64. doi: 10.1038/ki.2011.108. Epub 2011 Apr 27. PMID: 21525855CD38: A NAADP degrading enzyme. Schmid F, Bruhn S, Weber K, Mittrücker HW, Guse AH. FEBS Lett. 2011 Nov 16;585(22):3544-8. Epub 2011 Oct 19. PMID: 22020217

  • Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway. Hubert S, Rissiek B, Klages K, Huehn J, Sparwasser T, Haag F,Koch-Nolte F, Boyer O, Seman M, Adriouch S. J Exp Med. 2010 Nov 22;207(12):2561-8. doi: 10.1084/jem.20091154. Epub 2010 Oct 25. PMID: 20975043

    Expression of human cathepsin L or human cathepsin V in mouse thymus mediates positive selection of T helper cells in cathepsin L knock-out mice. Sevenich L, Hagemann S, Stoeckle C, Tolosa E, Peters C, Reinheckel T. Biochimie. 2010 Nov;92(11):1674-80. doi: 10.1016/j.biochi.2010.03.014. Epub 2010 Mar 25. PMID: 20347002

    Quantitative magnetic resonance imaging of enzyme activity on the cell surface: in vitro and in vivo monitoring of ADP-ribosyltransferase 2 on T cells. Bannas P, Graumann O, Balcerak P, Peldschus K, Kaul MG, Hohenberg H, Haag F, Adam G, Ittrich H, Koch-Nolte F. Mol Imaging. 2010 Aug;9(4):211-22. PMID: 20643024

    CCR6 recruits regulatory T cells and Th17 cells to the kidney in glomerulonephritis. Turner JE, Paust HJ, Steinmetz OM, Peters A, Riedel JH, Erhardt A, Wegscheid C, Velden J, Fehr S, Mittrücker HW, Tiegs G, Stahl RA, Panzer U. J Am Soc Nephrol. 2010 Jun;21(6):974-85. doi: 10.1681/ASN.2009070741. Epub 2010 Mar 18. PMID: 20299360

    Toward a unified nomenclature for mammalian ADP-ribosyltransferases. Hottiger MO, Hassa PO, Lüscher B, Schüler H, Koch-Nolte F. Trends Biochem Sci. 2010 Apr;35(4):208-19. doi: 10.1016/j.tibs.2009.12.003. Epub 2010 Jan 26. Review. PMID: 20106667

    A recombinant heavy chain antibody approach blocks ART2 mediated deletion of an iNKT cell population that upon activation inhibits autoimmune diabetes. Scheuplein F, Rissiek B, Driver JP, Chen YG, Koch-Nolte F, Serreze DV. J Autoimmun. 2010 Mar;34(2):145-54. doi: 10.1016/j.jaut.2009.08.012. Epub 2009 Oct 1. PMID: 19796917

    A role for IL-18 in protective immunity against Mycobacterium tuberculosis. Schneider BE, Korbel D, Hagens K, Koch M, Raupach B, Enders J, Kaufmann SH, Mittrücker HW, Schaible UE. Eur J Immunol. 2010 Feb;40(2):396-405. doi: 10.1002/eji.200939583. PMID: 19950174

    TLR2-, TLR4- and Myd88-independent acquired humoral and cellular immunity against Salmonella enterica serovar Typhimurium. Seibert SA, Mex P, Köhler A, Kaufmann SH, Mittrücker HW. Immunol Lett. 2010 Jan 4;127(2):126-34. doi: 10.1016/j.imlet.2009.10.008. Epub 2009 Nov 4. PMID: 19895846##

    Antigen processing and presentation in multiple sclerosis. Stoeckle C, Tolosa E. Results Probl Cell Differ. 2010;51:149-72. doi: 10.1007/400_2009_22. Review. PMID: 19582405

  • Stelekati E, Bahri R, D'Orlando O, Orinska Z, Mittrücker HW, Langenhaun R, Glatzel M, Bollinger A, Paus R, Bulfone-Paus S.#Mast cell-mediated antigen presentation regulates CD8+ T cell effector functions.#Immunity. 2009 Oct 16;31(4):665-76. Epub 2009 Oct 8.##

    Steinmetz OM, Turner JE, Paust HJ, Lindner M, Peters A, Heiss K, Velden J, Hopfer H, Fehr S, Krieger T, Meyer-Schwesinger C, Meyer TN, Helmchen U, Mittrücker HW, Stahl RA, Panzer U.#
    CXCR3 mediates renal Th1 and Th17 immune response in murine lupus nephritis.#J Immunol. 2009 Oct 1;183(7):4693-704. Epub 2009 Sep 4.##

    Rüder C, Höpken UE, Wolf J, Mittrücker HW, Engels B, Erdmann B, Wollenzin S, Uckert W, Dörken B, Rehm A.#The tumor-associated antigen EBAG9 negatively regulates the cytolytic capacity of mouse CD8+ T cells.#J Clin Invest. 2009 Aug;119(8):2184-203. doi: 10.1172/JCI37760. Epub 2009 Jul 20.# #

    Huber M, Heink S, Grothe H, Guralnik A, Reinhard K, Elflein K, Hünig T, Mittrücker HW, Brüstle A, Kamradt T, Lohoff M.#A Th17-like developmental process leads to CD8(+) Tc17 cells with reduced cytotoxic activity.#Eur J Immunol. 2009 Jul;39(7):1716-25.# #

    Erdmann H, Steeg C, Koch-Nolte F, Fleischer B, Jacobs T.# Sialylated ligands on pathogenic Trypanosoma cruzi interact with Siglec-E (sialic acid-binding Ig-like lectin-E).#Cell Microbiol. 2009 Nov;11(11):1600-11. Epub 2009 Jun 22.##

    Hong S, Schwarz N, Brass A, Seman M, Haag F, Koch-Nolte F, Schilling WP, Dubyak GR. #Differential regulation of P2X7 receptor activation by extracellular nicotinamide adenine dinucleotide and ecto-ADP-ribosyltransferases in murine macrophages and T cells. #J Immunol. 2009 Jul 1;183(1):578-92.##

    Wesolowski J, Alzogaray V, Reyelt J, Unger M, Juarez K, Urrutia M, Cauerhff A, Danquah W, Rissiek B, Scheuplein F, Schwarz N, Adriouch S, Boyer O, Seman M, Licea A, Serreze DV, Goldbaum FA, Haag F, Koch-Nolte F#. Single domain antibodies: promising experimental and therapeutic tools in infection and immunity#Med Microbiol Immunol. 2009 Jun 16.##

    Kernstock S, Koch-Nolte F, Mueller-Dieckmann J, Weiss MS, Mueller-Dieckmann C. #Cloning, expression, purification and crystallization as well as X-ray fluorescence and preliminary X-ray diffraction analyses of human ADP-ribosylhydrolase 1.#Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 May 1;65(Pt 5):529-32. Epub 2009 Apr 28.##

    Schwarz N, Fliegert R, Adriouch S, Seman M, Guse AH, Haag F, Koch-Nolte F.#Activation of the P2X7 ion channel by soluble and covalently bound ligands. #Purinergic Signal. 2009 Mar 3. [Epub ahead of print]# #

    Adriouch S, Scheuplein F, Bähring R, Seman M, Boyer O, Koch-Nolte F, Haag F.#Characterisation of the R276A gain-of-function mutation in the ectodomain of murine P2X7.# Purinergic Signal. 2009 Feb 21. [Epub ahead of print]# #

    Scheuplein F, Schwarz N, Adriouch S, Krebs C, Bannas P, Rissiek B, Seman M, Haag F, Koch-Nolte F.#NAD+ and ATP released from injured cells induce P2X7-dependent shedding of CD62L and externalization of phosphatidylserine by murine T cells. #J Immunol. 2009 Mar 1;182(5):2898-908# #

    Koch-Nolte F, Haag F, Guse AH, Lund F, Ziegler M.#Emerging roles of NAD+ and its metabolites in cell signaling.# Sci Signal. 2009 Feb 10;2(57):mr1.# #

    Bulanova E, Budagian V, Orinska Z, Koch-Nolte F, Haag F, Bulfone-Paus S.#ATP induces P2X7 receptor-independent cytokine and chemokine expression through P2X1 and P2X3 receptors in murine mast cells.# #

    Paust H-J, Turner J-E, Steinmetz OM, Peters A, Heymann F, Hölscher C, Wolf G, Kurts C, Mittrücker H-W, Stahl RAK, Panzer U.#The IL-23/Th17 axis contributes to renal injury in experimental glomerulonephritis.#J Am Soc Nephrol. 2009 May;20(5):969-79. Epub 2009 Apr 1.

  • Schröder J, Lüllmann-Rauch R, Himmerkus N, Pleines I, Nieswandt B, Orinska Z, Koch-Nolte F, Schröder B, Bleich M, Saftig P.
    Deficiency of the tetraspanin CD63 associated with kidney pathology but normal lysosomal function.
    Mol Cell Biol. 2008 Dec 15. [Epub ahead of print]

    Adriouch S, Bannas P, Schwarz N, Fliegert R, Guse AH, Seman M, Haag F, Koch-Nolte F.
    ADP-ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site.
    FASEB J. 2008 Mar;22(3):861-9.

    Heiss K, Jänner N, Mähnss B, Schumacher V, Koch-Nolte F, Haag F, Mittrücker HW.
    High sensitivity of intestinal CD8+ T cells to nucleotides indicates P2X7 as a regulator for intestinal T cell responses.
    J Immunol. 2008 Sep 15;181(6):3861-9.

    Niere M, Kernstock S, Koch-Nolte F, Ziegler M.
    Functional localization of two poly-ADP-ribose degrading enzymes to the mitochondrial matrix.
    Mol Cell Biol. 2008 Jan;28(2):814-24.

    Koch-Nolte F, Kernstock S, Mueller-Dieckmann C, Weiss MS, Haag F.
    Mammalian ADP-ribosyltransferases and ADP-ribosylhydrolases.
    Front Biosci. 2008 May 1;13:6716-29. Review.

    Kursar M, Jänner N, Pfeffer K, Brinkmann V, Kaufmann SH, Mittrücker HW.
    Requirement of secondary lymphoid tissues for the induction of primary and secondary T cell responses against Listeria monocytogenes.
    Eur J Immunol. 2008 Jan;38(1):127-38.

    Mansour WY, Schumacher S, Rosskopf R, Rhein T, Schmidt-Petersen F, Gatzemeier F, Haag F, Borgmann K, Willers H, Dahm-Daphi J.
    Hierarchy of nonhomologous end-joining, single-strand annealing and gene conversion at site-directed DNA double-strand breaks.
    Nucleic Acids Res. 2008 Jul;36(12):4088-98.

    Seifert A, Klonisch T, Wulfaenger J, Haag F, Dralle H, Langner J, Hoang-Vu C, Kehlen A.
    The cellular localization of autotaxin impacts on its biological functions in human thyroid carcinoma cells.
    Oncol Rep. 2008 Jun;19(6):1485-91.

    Niere M, Kernstock S, Koch-Nolte F, Ziegler M.
    Functional localization of two poly-ADP-ribose degrading enzymes to the mitochondrial matrix.
    Mol Cell Biol. 2008 Jan;28(2):814-24.

    Kursar M, Jänner N, Pfeffer K, Brinkmann V, Kaufmann SHE, Mittrücker H-W.
    Requirement of secondary lymphoid tissues for the induction of primary and secondary T cell responses against Listeria monocytogenes.
    Eur. J. Immunol. 2008. 38:127-138.

    Jänner N, Hahnke K, Mollenkopf H-J, Steinhoff U, Kaufmann SHE, Mittrücker H-W.
    Restricted expression of C-type lectin-like NK receptors by CD8 T cells in the murine small intestine.
    Immunology. 2008. 125:38-47.

    Heiss K, Jänner N, Mähnß B, Schumacher V, Koch-Nolte F, Haag F, Mittrücker H-W.
    High sensitivity of intestinal CD8+ T cells to nucleotides indicates P2X7 as a regulator for intestinal T cell responses.
    J. Immunol. 2008. 181:3861-3869.

    Turner J-E, Paust H-J, Steinmetz OM, Peters A, Meyer-Schwesinger C, Heymann F, Helmchen U, Horuk R, Wenzel U, Kurts C, Mittrücker H-W, Stahl RAK, Panzer U.
    CCR5 deficiency aggravates crescentic glomerulonephritis in mice.
    J. Immunol. 2008. 181:6546-6556.

  • Koch-Nolte F, Reyelt R, Schössow B, Schwarz N, Scheuplein F, Rothenburg S, Haag F, Alzogaray V, Cauerhff A, Goldbaum F.
    Single domain antibodies from llama effectively and specifically block T cell ecto-ADP-ribosyltransferase ART2.2 in vivo.
    FASEB J. 2007, Nov;21(13):3490-8.

    Möller M, Jung C, Adriouch S, Dubberke G, Seyfried F, Seman M, Haag F, Koch-Nolte F.
    Monitoring the expression of purinoceptors and nucleotide-metabolizing ecto-enzymes with antibodies directed against proteins in native conformation.
    Purinergic Signalling 2007 3:359-366

    Hansen K, Wagner B, Hamel W, Schweizer M, Haag F, Westphal M, Lamszus K.
    Autophagic cell death induced by TrkA receptor activation in human glioblastoma cells.
    J Neurochem. 2007 Oct;103(1):259-75. Epub 2007 Jul 17.

    Hong S, Brass A, Seman M, Haag F, Koch-Nolte F, Dubyak GR.
    Lipopolysaccharide, IFN-{gamma}, and IFN-beta Induce Expression of the Thiol-Sensitive ART2.1 Ecto-ADP-Ribosyltransferase in Murine Macrophages.
    J Immunol. 2007 Nov 1;179(9):6215-27.

    Kretschmer B, Luthje K, Guse AH, Ehrlich S, Koch-Nolte F, Haag F, Fleischer B, Breloer M.
    CD83 modulates B Cell function in vitro: increased IL-10 and reduced Ig secretion by CD83Tg B cells.
    PLoS ONE. 2007 Aug 15;2(1):e755.

    Adriouch S, Hubert S, Pechberty S, Koch-Nolte F, Haag F, Seman M.
    NAD+ Released during Inflammation Participates in T Cell Homeostasis by Inducing ART2-Mediated Death of Naive T Cells In Vivo.
    J Immunol. 2007 Jul 1;179(1):186-94.

    Panzer U, Steinmetz OM, Paust HJ, Meyer-Schwesinger C, Peters A, Turner JE, Zahner G, Heymann F, Kurts C, Hopfer H, Helmchen U, Haag F, Schneider A, Stahl RA.
    Chemokine Receptor CXCR3 Mediates T Cell Recruitment and Tissue Injury in Nephrotoxic Nephritis in Mice.
    J Am Soc Nephrol. 2007 May 30

    Lepenies B, Gaworski I, Tartz S, Langhorne J, Fleischer B, Jacobs T.
    CTLA-4 blockade differentially influences the outcome of non-lethal and lethal Plasmodium yoelii infections.
    Microbes Infect. 2007 May;9(6):687-94. Epub 2007 Feb 23.

    Breloer M, Kretschmer B, Luthje K, Ehrlich S, Ritter U, Bickert T, Steeg C, Fillatreau S, Hoehlig K, Lampropoulou V, Fleischer B.
    CD83 is a regulator of murine B cell function in vivo.
    Eur J Immunol. 2007 Mar;37(3):634-48.

    Wulff H, Krieger T, Krueger K, Stahmer I, Thaiss F, Schaefer H, Block A
    Cloning and characterization of an adenoviral vector for highly efficient and doxycycline - suppressible expression of bioactive human single - chain interleukin 12 in colon cancer
    BMC Biotechnology 2007, 7:35 (26 June 2007)

    Schrepfer S, Deuse T, Koch-Nolte F, Krieger T, Haddad M, Schafer H, Pelletier MP, Robbins RC, Reichenspurner H.
    FK778 in experimental xenotransplantation: a detailed analysis of drug efficacy.
    J Heart Lung Transplant. 2007 Jan;26(1):70-7.

    Lewerenz J, Ding X, Matschke J, Schnabel C, Emami P, von Borczyskowski D, Buchert R, Krieger T, de Wit M, Munchau A.
    Dementia and leukoencephalopathy due to lymphomatosis cerebri.
    J Neurol Neurosurg Psychiatry. 2007 Jan 8;

    Sack U, Conrad K, Csernok E, Frank I, Haass M, Krieger T, Seyfarth M, Schlosser U, Schmidt RE, Witte T.
    Standardization of autoimmune diagnostics in Germany: activities of the German group in the European Autoimmune Standardization Initiative.
    Ann N Y Acad Sci. 2007 Aug;1109:31-6.

    Gajendran N, Mittrucker HW, Bordasch K, Heinemann E, Koch M, Kaufmann SH.
    Regional IFN{gamma} expression is insufficient for efficacious control of food-borne bacterial pathogens at the gut epithelial barrier.
    Int Immunol. 2007 Sep;19(9):1075-81. Epub 2007 Aug 13.

    Mittrücker HW, Steinhoff U, Kohler A, Krause M, Lazar D, Mex P, Miekley D, Kaufmann
    Poor correlation between BCG vaccination-induced T cell responses and protection against tuberculosis.
    Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12434-9. Epub 2007 Jul 18.

    Kursar M, Koch M, Mittrucker HW, Nouailles G, Bonhagen K, Kamradt T, Kaufmann SH.
    Cutting Edge: Regulatory T cells prevent efficient clearance of Mycobacterium tuberculosis.
    J Immunol. 2007 Mar 1;178(5):2661-5.

    Kursar M, Koch M, Mittrücker H-W, Nouailles G, Kamradt T, Bonhagen K, Kaufmann SHE.
    Regulatory T cells prevent efficient clearance of Mycobacterium tuberculosis.
    J. Immunol. 2007. 178: 2661-2665.

    Mittrücker H-W, Steinhoff U, Köhler A, Krause M, Lazar D, Mex P, Miekley D, Kaufmann SHE.
    Poor correlation between BCG vaccination-induced T cell responses and protection against tuberculosis.
    Proc. Natl. Acad. Sci. USA. 2007. 104:12434-12439.

    Gajendran G, Mittrücker H-W, Bordasch K, Heinemann E, Koch M, Kaufmann SHE.
    Regional interferon-gamma expression is insufficient for efficacious control of food-borne bacterial pathogens at the gut epithelial barrier.
    Int. Immunol. 2007. 19:1075-1081.

  • Billington RA, Bruzzone S, De Flora A, Genazzani AA, Koch-Nolte F, Ziegler M, Zocchi E.
    Emerging functions of extracellular pyridine nucleotides.
    Mol Med. 2006 Nov-Dec;12(11-12):324-7.

    Deigendesch N, Koch-Nolte F, Rothenburg S
    ZBP1 subcellular localization and association with stress granules is controlled by its Z-DNA binding domains
    Nucl. Acids Res. 2006 Oct; 34(18):5007-5020

    Mueller-Dieckmann C, Kernstock S, Lisurek M, von Kries JP, Haag F, Weiss M, Koch-Nolte F
    The structure of human ADP-ribosylhydrolase 3 (ARH3) provides insights into the reversibility of protein ADP-ribosylation
    PNAS 2006 Oct; 103(41):15026-15031

    Koch-Nolte F, Adriouch S, Bannas P, Krebs C, Scheuplein F, Seman M, Haag F
    ADP-ribosylation of membrane proteins: Unveiling the secrets of a crucial regulatory mechanism in mammalian cells
    Ann Med. 2006 May; 38(3):188-199

    Chen J, Chen Y-G, Reifsnyder PC, Schott WH, Lee C-H, Osborne M, Scheuplein F, Haag F, Koch-Nolte F, Serreze D, Leiter EH
    Targeted Disruption of CD38 Accelerates Autoimmune Diabetes in NOD/Lt Mice by Enhancing Autoimmunity in an ADP-Ribosyltransferase 2-Dependent Fashion
    J Immunol. 2006 Apr 16; 176(8): 4590-4599

    Kernstock S, Koch-Nolte F, Mueller-Dieckmann J, Weiss MS, Mueller-Dieckmann C
    Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of human ARH3, the first eukaryotic protein-ADP ribosylhydrolase
    Acta Cryst F. 2006 Mar 1; 62(Pt3): 224-227

    Friedrich M, Grahnert A, Paasch U, Tannapfel A, Koch-Nolte F, Hauschildt S
    Expression of toxin-related human mono-ADP-ribosyltransferase 3 in human testis
    Asian J Androl. 2006 May; 8(3):281-287

    Deuse T, Schrepfer S, Koch-Nolte F, Haddad M, Schafer H, Detter C, Reichenspurner H
    Sirolimus and FK778: a comparison of two anti-proliferative immunosuppressants for prevention of experimental obliterative airway disease
    Transpl Int. 2006 Apr; 19(4):310-318

    Schrepfer S, Deuse T, Koch-Nolte F, Detter C, Reichenspurner H
    FK778: new cellular and molecular mechanisms of action
    Transpl Proc. 2006 Apr; 38(3):757-761

  • Deuse T, Schrepfer S, Koch-Nolte F, Haddad M, Schwedhelm E, Boger R, Schafer H, Detter C, Reichenspurner H
    FK778 and tacrolimus prevent the development of obliterative airway disease after heterotopic rat tracheal transplantation
    J Heart Lung Transplant. 2005 Nov; 24(11):1844-1854

    Koch-Nolte F, Glowacki G, Bannas P, Braasch F, Dubberke G, Ortolan E, Funaro A, Malavasi F, Haag F
    Use of genetic immunization to raise antibodies recognizing toxin-related cell surface ADP-ribosyltransferases in native conformation
    Cell Immunol. 2005 Jul-Aug; 236(1-2):66-71

    Chen J, Reifsnyder PC, Scheuplein F, Schott WH, Mileikovsky M, Soodeen-Karamath S, Nagy A, Dosch MH, Ellis J, Koch-Nolte F, Leiter EH
    "Agouti NOD": identification of a CBA-derived Idd locus on Chromosome 7 and its use for chimera production with NOD embryonic stem cells
    Mamm Genome. 2005 Oct; 16(10):775-783

    Schrepfer S, Deuse T, Schafer H, Koch-Nolte F, Braendle W, Reichenspurner H
    The phytoestrogen biochaninA weakens acute cardiac allograft rejection without affecting the reproductive system
    Transpl Immunol. 2005 Oct; 15(1):45-53

    Otto H, Reche PA, Bazan F, Dittmar K, Haag F, Koch-Nolte F
    In silico characterization of the family of PARP-like poly(ADP-ribosyl)transferases (pARTs)
    BMC Genomics. 2005 Oct 4; 6:139

    Rothenburg S, Haag F, Koch-Nolte F, Carter C, Graham M, Butcher GW
    Characterization of multiple alleles of the T-cell differentiation marker ART2 (RT6) in inbred and wild rats
    Immunogenetics. 2005 Nov; 57(10): 739-749

    Parusel I, Kahl S, Braasch F, Glowacki G, Halverson GR, Reid ME, Schawalder A, Ortolan E, Funaro A, Malavasi F, Hardie D, Halder S, Buckley CD, Haag F, Koch-Nolte F
    A panel of monoclonal antibodies recognizing GPI-anchored ADP-ribosyltransferase ART4 the carrier of the Dombrock blood group antigens
    Cell Immunol. 2005 Jul-Aug; 236(1-2): 59-65

    Adriouch S, Dubberke G, Diessenbacher P, Rassendren F, Seman M, Haag F, Koch-Nolte F
    Probing the expression and function of the P2X7 purinoceptor with antibodies raised by genetic immunization
    Cell Immunol. 2005 Jul-Aug; 236(1-2): 72-77

    McKinnell C, Sharpe RM, Mahood K, Hallmark N, Scott H, Ivell R, Staub C, Jegou B, Haag F, Koch-Nolte F, Hartung S
    Expression of insulin-like factor 3 protein in the rat testis during fetal and postnatal development and in relation to cryptorchidism induced by in utero exposure to di (n-Butyl) phthalate
    Endocrinology. 2005 Oct; 146(10): 4536-4544

    Krebs C, Adriouch S, Braasch F, Koestner W, Leiter EH, Seman M, Lund FE, Oppenheimer N, Haag F, Koch-Nolte F
    CD38 controls ADP-ribosyltransferase-2-catalyzed ADP-Ribosylation of T cell surface proteins
    J Immunol. 2005 Mar 15; 174(6): 3298-3305

    Kawamura H, Aswad F, Minagawa M, Malone K, Kaslow H, Koch-Nolte F, Schott WH, Leiter EH, Dennert G
    P2X7 receptor-dependent and -independent T cell death is induced by nicotinamide adenine dinucleotide
    J Immunol. 2005 Feb 15; 174(4): 1971-1979

    Rothenburg S, Deigendesch N, Dittmar K, Koch-Nolte F, Haag F, Lowenhaupt K, Rich A
    A PKR-like eukaryotic initiation factor 2alpha kinase from zebrafish contains Z-DNA binding domains instead of dsRNA binding domains
    Proc Natl Acad Sci U S A. 2005 Feb 1; 102(5): 1602-1607

    Peter Bannas, Sahil Adriouch, Sarah Kahl, Fenja Braasch, Friedrich Haag, and Friedrich Koch-Nolte
    Activity and specifity of toxin-related mouse T cell ecto-ADP-ribosyltransferase ART2.2 depends on its association with lipid rafts
    Blood. 2005 May 1; 105(9):3663-3670

    Garcia-Palma L, Horn S, Haag F, Diessenbacher P, Streichert T, Mayr GW, Jucker M
    Up-regulation of the T cell quiescence factor KLF2 in a leukaemic T-cell line after expression of the inositol 5'-phosphatase SHIP-1
    Br J Haematol. 2005 Dec; 131(5): 628-631

    Kim C, Gajendran N, Mittrücker H-W, Weiwad M, Song Y-H, Hurwitz R, Wilmanns M, Fischer G, Kaufmann SHE.
    Human #-defensins neutralize anthrax lethal toxin and protect against its fatal consequences.
    Proc. Natl. Acad. Sci. USA. 2005. 102:4830-4835.

    Rohrbach F, Weth R, Kursar M, Sloots A, Mittrücker H-W, Wels WS.
    Targeted delivery of the ErbB2/HER2 tumor antigen to professional antigen presenting cells results in effective antitumor immunity.
    J. Immunol. 2005. 174:5481-5489.

    Kursar M, Höpken UE, Koch M, Köhler A, Lipp M, Kaufmann SHE, Mittrücker H-W.
    Differential requirements for the chemokine receptor CCR7 in T-cell activation during Listeria monocytogenes infection.
    J. Exp. Med. 2005. 201:1447-1457.

    Wiemann K, Mittrücker H-W, Feger U, Welte SA, Yokoyama WM, Spies T, Rammensee H-G, Steinle A.
    Systemic NKG2D down-regulation impairs NK and CD8 T Cell responses in vivo.
    J. Immunol. 2005. 175:720-729.

    Prinz I, Kursar M, Mittrücker H-W, Aguado E, Steinhoff U, Kaufmann SHE, Malissen B.
    Autistic effector T cells in mice with a point mutation in the LAT adaptor fail to respond to Listeria monocytogenes infection.
    Int. Immunol. 2005. 17:951-957.

    Mittrücker H-W, Kaufmann SHE.
    Natural regulatory T cells and infection.
    Curr. Opin. Organ Transplant. 2005. 10:320-325.

  • Lieke T, Graefe SE, Klauenberg U, Fleischer B, Jacobs T.
    NK cells contribute to the control of Trypanosoma cruzi infection by killing free parasites by perforin-independent mechanisms.
    Infect Immun. 2004 Dec;72(12):6817-25.

    Hammer E, Kutsche K, Haag F, Ullrich K, Sudbrak R, Willig RP, Braulke T, Kubler B
    Mono-allelic expression of the IGF-I receptor does not affect IGF responses in human fibroblasts
    Eur J Endocrinol. 2004 Oct; 151(4): 521-529

    F. Scheuplein, C. Krebs, S. Adriouch, M. Seman, F. Haag, F. Koch-Nolte
    Comparative analyses of ATP and NAD induced Celldeath
    In: "Immunology 2004" (The Proceedings of the 12th International Congress of Immunology) ed: E. Skamene, Medimond S.r.l., Bologna, Italy
    Cytokine Network, Regulatory Cells, Signalling, and Apoptosis; pp. 505-509, 2004

    Deuse T, Schrepfer S, Schafer H, Koch-Nolte F, Schwedhelm E, Boger RH, Reichenspurner H
    FK778 attenuates lymphocyte-endothelium interaction after cardiac transplantation: in vivo and in vitro studies.
    Transplantation. 2004 Jul 15; 78(1):71-77

    Seman M, Adriouch S, Haag F, Koch-Nolte F.
    Ecto-ADP-ribosyltransferases (ARTs): emerging actors in cell communication and signaling.
    Curr Med Chem. 2004 Apr; 11(7):857-872

    Jacobs T, Plate T, Gaworski I, Fleischer B.
    CTLA-4-dependent mechanisms prevent T cell induced-liver pathology during the erythrocyte stage of Plasmodium berghei malaria.
    Eur J Immunol. 2004 Apr;34(4):972-80.

    Graefe SE, Jacobs T, Wachter U, Broker BM, Fleischer B.
    CTLA-4 regulates the murine immune response to Trypanosoma cruzi infection.
    Parasite Immunol. 2004 Jan;26(1):19-28.

    Kursar M, Bonhagen K, Köhler A, Kamradt T, Kaufmann SHE, Mittrücker H-W.
    Antigen-specific CD8+ T cell response in intestinal tissues during murine listeriosis.
    Microbes Infect. 2004. 6:8-16

    Kursar M, Mittrücker H-W, Koch M, Köhler A, Herma M, Kaufmann SHE.
    Protective T cell response against intracellular pathogens in the absence of Toll-like receptor signaling via Myeloid differentiation factor 88.
    Int. Immunol. 2004. 16:415-421

    Kursar M, Köhler A, Kaufmann SHE, Mittrücker H-W.
    Depletion of CD4+ T cells during immunization with non-viable Listeria monocytogenes causes enhanced CD8+ T cell mediated protection against listeriosis.
    J. Immunol. 2004. 172:3167-3172.

    Lohoff M, Mittrücker H-W, Brüstle A, Sommer F, Casper B, Ferrick DA, Duncan GS, Mak TW.
    Enhanced TCR-induced apoptosis in Interferon-Regulatory-Factor 4-deficient CD4+ cells.
    J. Exp. Med. 2004. 200:247-253.

    Qimron U, Madar N, Mittrücker H-W, Zilka A, Yosef I, Bloushtain N, Kaufmann SHE, Rosenshine I, Apte RN, Porgador A.
    Identification of Salmonella typhimurium genes responsible for interference with peptide presentation on MHC class I molecules: #yej Salmonella mutants induce superior CD8+ T cell responses.
    Cell. Microbiol. 2004. 6:1057-1070.

    Kretschmer U, Bonhagen K, Debes GF, Mittrücker H-W, Erb KJ, Liesenfeld O, Zaiss D, Kamradt T, Hamann A.
    Expression of selectin ligands on murine effector- and IL-10 producing CD4+ T cells from non-infected and infected tissues.
    Eur. J. Immunol. 2004. 34:3070-3081.

    Mittrücker H-W, Kaufmann SHE.
    Regulatory T cells and infection: suppression revisited.
    Eur. J. Immunol. 2004. 34:306-312.

    Kaufmann SHE, Mittrücker H-W.
    Vaccination against tuberculosis: current status and future promise.
    Semin. Respir. Crit. Care Med. 2004. 25:345-352.

  • Scheuplein F, Adriouch S, Glowacki G, Haag F, Seman M, Koch-Nolte F.
    Triggering of T-cell apoptosis by toxin-related ecto-ADP-ribosyltransferase ART2.
    Ann N Y Acad Sci. 2003 Dec; 1010:296-299

    Diessenbacher P, Bartels K, Koch-Nolte F, Haag F.
    T-cell survival regulator LKLF is not involved in inappropriate apoptosis of diabetes-prone BBDP rat T cells.
    Ann N Y Acad Sci. 2003 Dec; 1010:548-551

    Seman M, Adriouch S, Scheuplein F, Krebs C, Freese D, Glowacki G, Deterre P, Haag F, Koch-Nolte F.
    NAD-induced T cell death: ADP-ribosylation of cell surface proteins by ART2 activates the cytolytic P2X7 purinoceptor.
    Immunity. 2003 Oct; 19(4):571-582.

    Krebs C, Koestner W, Nissen M, Welge V, Parusel I, Malavasi F, Leiter EH, Santella RM, Haag F, Koch-Nolte F.
    Flow cytometric and immunoblot assays for cell surface ADP-ribosylation using a monoclonal antibody specific for ethenoadenosine.
    Anal Biochem. 2003 Mar 1; 314(1):108-115

    Gbadamosi J, Buhmann C, Tessmer W, Moench A, Haag F, Heesen C.
    Effects of Mitoxantrone on Multiple Sclerosis Patients' Lymphocyte Subpopulations and Production of Immunoglobulin, TNF-alpha and IL-10.
    Eur Neurol. 2003; 49(3):137-141.

    Ritter H, Koch-Nolte F, Marquez VE, Schulz GE.
    Substrate Binding and Catalysis of Ecto-ADP-ribosyltransferase 2.2 from Rat.
    Biochemistry. 2003 Sep 2; 42(34):10155-10162

    Kunerth S, Mayr GW, Koch-Nolte F, Guse AH.
    Analysis of subcellular calcium signals in T-lymphocyes.
    Cell Signal. 2003 Aug; 15(8):783-792

  • Friedrich Haag, Dunja Freese, Felix Scheublein, Wiebke Ohlrogge, Sahil Adriouch, Michel Seman, Friedrich Koch-Nolte
    T Cells of Different Developmental Stages Differ in Sensitivity to Apoptosis Induced by Extracellular NAD
    Dev Immunol. 2002 Dec; 9(4):197-202.

    S. Adriouch, C. Dox, W. Koestner, V.Welge, M. Seman, F. Koch-Nolte, & F. Haag:
    Cutting edge: A natural P451L mutation in the cytoplasmic domain impairs the function of the mouse P2X7 receptor
    J. Immunol. 169: 4108-4112 (2002)

    W. Ohlrogge, F. Haag, M. Nissen, H. Löhler, M. Seman, D. Littman, N. Killeen & F. Koch-Nolte:
    Generation and characterization of ecto-ADP-ribosyltransferase ART2.1/ART2.2-deficient mice
    Mol. Cell. Biol. 22: 7535-7542 (2002)

    C. Mueller-Dieckmann, H. Ritter, F. Haag, F. Koch-Nolte & G. Schulz:
    Structure of the ecto-ADP-ribosyltransferase ART2.2 from rat
    J. Mol. Biol. 322: 687-696 (2002)

    G. Glowacki, R. Braren,K. Firner, M. Nissen, M. Kühl, P. Reche, F. Bazan, M. Cetkovic-Cvrlje, E. H. Leiter, F. Haag, & F. Koch-Nolte:
    The gene family of toxin related ecto-ADP-ribosyltransferases in man and mouse
    Protein Science 11: 1657-1670 (2002)

    H.J. Stellbrink, J. van Lunzen, M. Westby, E. O'Sullivan E, C. Schneider C, M. Kurowski, A. Adam, L. Weitner, B. Kuhlmann B, C. Hoffmann C, S. Fenske S, S.P. Aries SP, O. Degen O, C. Eggers C, H. Petersen H, F. Haag F, H.A. Horst, K. Dalhoff , C. Möcklinghoff, N. Cammack, K. Tenner-Racz & P. Racz:
    Virological and Immunological Effects of Highly Active Anti-Retroviral Therapy (HAART) Combined with Interleukin-2 in the Treatment of Asymptomatic HIV-1 Infection - Results of a randomized trial (COSMIC)
    AIDS 16: 1479-1487 (2002)

    S. Rothenburg, M. Eiben, F. Koch-Nolte, & F. Haag:
    Independent integration of rodent identifier (ID) elements into some RT6 alleles of rattus norvegicus and rattus rattus.
    J. Mol. Evol. 55: 251-259 (2002)

    C. Mueller-Dieckmann, T. Scheuermann, K. Wursthorn, J. Schröder, G. Schulz, F. Haag, & F. Koch-Nolte "
    Expression, purification, crystallization and preliminary X-ray analysis of rat ecto-ADP-ribosyltransferase 2 (ART2.2)
    Acta Crystallogr D. 58: 1211-1213 (2002)

    A. Grahnert, M. Friedrich, M.Pfister, F. Haag, F. Koch-Nolte & S. Hauschildt:
    Mono ADP-ribosyltransferases in human monocytes: regulation by lipopolysaccharide
    Biochem J., 362: 717-723 (2002)

    S. Rothenburg, T. Schwartz, F. Koch-Nolte, & F. Haag:
    Complex regulation of the human gene for the Z-DNA binding protein DLM-1
    Nucl. Acids. Res. 30: 993-1000 (2002)

    Mittrücker H-W, Köhler A, Kaufmann SHE.
    Characterization of the murine T-lymphocyte response to Salmonella enterica serovar Typhimurium Infection.
    Infect. Immun. 2002. 70:199-203.

    Kursar M, Bonhagen K, Köhler A, Kamradt T, Kaufmann SHE, Mittrücker H-W.
    Organ-specific CD4+ T cell response during Listeria monocytogenes infection,
    J. Immunol. 2002. 168:6382-6387.

    Lohoff M, Mittrücker H-W, Prechtl S, Bischof S, Sommer F, Kock S, Ferrick DA, Duncan GS, Gessner A, Mak TW.
    IL-4 triggers T helper 1 cell differentiation in the absence of Interferon-regulatory-factor 4.
    Proc. Natl. Acad. Sci. USA. 2002. 99:11808-11812.

    Köbernick H, Grode L, David JR, Rohde W, Rolph MS, Mittrücker H-W, Kaufmann SHE.
    Macrophage migration inhibitory factor (MIF) plays a pivotal role in protective immunity against Salmonella typhimurium.
    Proc. Natl. Acad. Sci. USA. 2002. 99:13681-13686.

    Mittrücker H-W, Kursar M, Köhler A, Yanagihara D, Yoshinaga SK, Kaufmann SHE.
    Inducible costimulator protein (ICOS) controls the T cell response against Listeria monocytogenes.
    J. Immunol. 2002. 169:5813-5817.

    Kursar M, Bonhagen K, Fensterle J, Köhler A, Hurwitz R, Kamradt T, Kaufmann SHE, Mittrücker H-W.
    Regulatory CD4+ CD25+ T cells restrict memory CD8+ T cell responses.
    J. Exp. Med. 2002. 196:1585-1592.

  • S. Rothenburg, F. Koch-Nolte, A. Rich, & F. Haag:
    A polymorphic dinucleotide repeat in the rat nucleolin gene forms Z-DNA and inhibits promoter activity
    Proc. Natl. Acad. Sci. 98:8985-8990 (2001)

    S. Rothenburg, F. Koch-Nolte, & F. Haag:
    DNA methylation and Z-DNA formation as mediators of quantitative differences in the expression of alleles
    Immunological Reviews 184: 286-298 (2001)

    H.G. Thiele, & F. Haag:
    The RT6 System of the Rat
    Immunological Reviews 184: 96-108 (2001)

    G. Glowacki, R. Braren, M. Nissen, F. Haag, & F. Koch-Nolte:
    Molecular characterization of the gene for mouse NAD+:arginine ecto-mono(ADP-ribosyl)transferase, Art 5
    Gene 275: 267-277 (2001)

    S. Adriouch, W. Ohlrogge, F. Haag, F. Koch-Nolte, & M. Serman:
    Rapid induction of naive T cell apoptosis by ecto-nicotinamide adenine dinucleotide: requirement for mono(ADP-ribosyl)transferase 2 and a downstream effector
    J. Immunol. 167, 196-203 (2001)

    V. Ablamunits, F. Koch-Nolte, P.Reche, F. Haag & E.H. Leiter:
    Changing patterns of cell surface mono (ADP-ribosyl) transferase antigen Art2.2 on resting versus cytopathically-activated T cells in NOD/Lt mice
    Diabetologia. 44, 848-858 (2001)

    F. Koch-Nolte, P.Reche, F. Haag & F. Bazan:
    ADP-ribosyltransferases: plastic tools for inactivating proteins and small molecular weight targets
    J. Biotechnol. 92:81-87 (2001)

    S. Rothenburg, F. Koch-Nolte, H.G. Thiele & F. Haag:
    DNA methylation contributes to tissue- and allele-specific expression of the T cell differentiation marker RT6
    Immunogenetics 52, 231-241 (2001)

    F. Koch-Nolte, F. Haag, U. Lindberg & M. Rhen:
    The best defense is a good offense - Salmonella deploys an ADP-ribosylating toxin: response
    Trends in Microbiol. 9, 4-5 (2001)

    D. Tezcan-Merdol, T. Nyman, U. Lindberg, F. Haag, F. Koch-Nolte & M. Rhen:
    Actin is ADP-ribosylated by the Salmonella enterica virulence-associated protein SpvB
    Mol. Microbiol. 39: 606-619 (2001)

    F. Koch-Nolte, H.Otto, G. Glowacki, D. Teczan, M. Rhen & F.Haag:
    Using PSI-Blast to analyze the relation of bacterial toxins and mammalian ADP-ribosyltransferases and to discover a new, potentially interesting family member
    The Infectious Disease Review Supl. 3, 62-69 (2001)

    Mittrücker H-W, Kursar M, Köhler A, Hurwitz R, Kaufmann SHE.
    Role of CD28 for the generation and expansion of antigen-specific CD8+ T lymphocytes during infection with Listeria monocytogenes.
    J. Immunol. 2001. 167:5620-5627.

  • S. Kahl, M. Nissen, R. Girisch, T. Duffy, F. Haag, E.H. Leiter & F. Koch- Nolte:
    Metalloprotease-mediated shedding of enzymically active mouse ecto-ADP-ribosyltransferase ART2.2 upon T cell activation
    J. Immunol. 165: 4463-4469 (2000)

    H. Otto, D. Teczan-Merdol, R. Gririsch, F. Haag, M. Rhen & F. Koch-Nolte:
    The SpvB gene product of the Salmonella enterica virulence plasmid is a mono(ADP-ribosyl)transferase
    Mol. Microbiol. 37: 1106-1115 (2000)

    F. Koch-Nolte, P.Reche, F. Haag & F. Bazan:
    Can the catalytic domain of ADP-ribosyltransferases be redesigned to inactivate new targets?
    in: Proceedings of the 4th International Congress of Biochemical Engineering Fraunhofer IRB Verlag, Stuttgart, FRG: 30-34 (2000)

    F. Koch-Nolte, M. Aberomeit, A. Gerber, S. Kahl, W. Ohlrogge, G. Glowacki, R. Braren, J. Fang, S. Rothenburg, & F. Haag:
    Molecular characterization of a family of NAD+-metabolizing ectoenzymes in mice and men: endogenous relatives of ADP-ribosylating bacterial toxins
    in: Ecto ATPases and related Ecto-Nucleotidases ( L. Vanduffel, ed.) Shaker Publishing BV, Maastricht, NL: 221-233 (2000)

    Mittrücker H-W, Raupach B, Köhler A, Kaufmann SHE.
    Role of B lymphocytes in protective immunity against Salmonella typhimurium infection.
    J. Immunol. 2000. 164:1648-1652.

    Mittrücker H-W, Köhler A, Kaufmann SHE.
    Substantial in vivo proliferation of CD4+ and CD8+ T lymphocytes during secondary Listeria monocytogenes infection.
    Eur. J. Immunol. 2000. 30:1053-1059.

    Lohoff M, Duncan GS, Ferrick D, Mittrücker H-W, Bischof S, Prechtl S, Röllinghoff M, Schmitt E, Pahl A, Mak TW.
    Deficiency in the transcription factor interferon regulatory factor (IRF)-2 leads to severely compromised development of natural killer and T helper type 1 cells.
    J. Exp. Med. 2000. 192:325-335.

    Mittrücker H-W, Kaufmann SHE.
    Immune response to infection with Salmonella typhimurium in mice.
    J. Leukoc. Biol. 2000. 67:457-463.

  • Berlin-Rufenach C, Otto F, Mathies M, Westermann J, Owen MJ, Hamann A, Hogg N.:
    Lymphocyte migration in lymphocyte function-associated antigen (LFA)-1-deficient mice
    J. Exp. Med. 189:1467-1478 (1999)

    F. Koch-Nolte, T. Duffy, M. Nissen, S. Kahl, N. Killeen, V. Ablumatis, F. Haag & E.H. Leiter:
    A new monoclonal antibody detects a developmentally-regulated ecto-ADP-ribosyltransferase on T cells: subset distribution, inbred strain variation, and modulation upon T cell activation
    J. Immunol. 163: 6014-6022 (1999)

    S. Rothenburg, F. Koch-Nolte, H.G. Thiele & F. Haag:
    Evidence that allelic variations inthe main RT6 promoter modulate transcriptional activity
    Transpl. Proc. 31: 1626-1628 (1999)

    J. Fang, S. Rothenburg, F. Koch-Nolte, H.G. Thiele & F. Haag:
    Mutation of a putative TATA motif does not affect transcription bz the promoter of the rat T cell differentiation marker RT6
    Transpl. Proc. 31: 1629-1630 (1999)

    S. Rothenburg, F. Koch-Nolte, H.G. Thiele & F. Haag:
    Expression of the T-cell differentiation antigen RT6.2 in T-cell lines correlates with hypomethylation of the RT6 promotes
    Transpl. Proc. 31: 1624-1625(1999)

    F. Haag & F.Koch- Nolte:
    Oberflächenenzyme von T-Zellen modulieren die Signalübermittlung an der "immunologischen Synapse
    BIOforum, 22: 534-536 (1999)

    F. Koch-Nolte, F. Haag, F. Iglauer & J. Dimigen:
    DNA immunization - an interesting option for raising antibodies against molecularily characterized proteins
    in: Versuchstierkunde: Mittler zwischen Forschung und Tierschutz Zentrale Universitätsdruckerei, Berlin: 71-87 (1999)

  • J. Siveke, A. Hamann:
    Cutting edge: Th1 and Th2 cells respond differentially to chemokines
    J. Immunol. 160: 550-554 (1998)

    W. Tietz, Y. Allemand, E. Borges, D. v. Laer, R. Hallmann, D. Vestweber, A. Hamann:
    CD4+ T-cells only migrate into inflamed skin if they express ligands for E- und P-selection
    J. Immunol. 161: 963-970 (1998)

    F. Haag & F. Koch-Nolte:
    Endogenous relatives of ADP-ribosylating bacterial toxins in mice and men: potential regulators of immune cell functions
    J. Biol. Reg. Homeos Ag. 12: 53-62 (1998)

    R. Braren, G. Glowacki, M. Nissen, F. Haag & F. Koch-Nolte:
    Molecular characterization and expression of the gene for mouse NAD+:arginine ecto-mono(ADP-ribosyl)transferase, Art1
    Biochem. J. 336: 561-8 (1998)

    S. Thoma, K. Bonhagen, D. Vestweber, A. Hamann, J. Reimann:
    Expression of selectin-binding epitopes and cytokines by CD4+ T cells repopulating scid mice with colitis
    Eur. J. Immunol. 28: 1785-1797 (1998)

    P. Jonas, B. Holzmann, D. Jablonski-Westrich, A. Hamann:
    The dissemination capacity of murine lymphoma cells is not dependent on efficient homing
    Int. J. Cancer 77: 402-407 (1998)

    A. Scheffold, M. Löhning, A. Richter, M. Assenmacher, R. Manz, F. Austrup, A. Hamann, A. Radbruch:
    Analysis and sorting of T-cells according to cytokine expression
    Eur. Cytokine Netw. 9, Suppl. 3, 5-11 (1998)

    A. Hamann:
    Adhäsionsmoleküle, zelluläre Interaktionen und Zellmigration
    In: Aktuelle Allergologie. W. Heppt, H. Renz, M. Röcken, eds. Springer Verlag, Heidelberg, p.61-68 (1998)

  • F. Austrup, D. Vestweber, E. Borges, M. Löhning, R. Bräuer, U. Herz, H. Renz, R. Hallmann, A. Scheffold, A. Radbruch, A. Hamann:
    P- and E-selectin mediate recruitment of T helper 1 but not T helper 2 cells into inflamed tissues
    Nature 385: 81-83 (1997)

    M. Wroblewski, A. Hamann:
    CD45-mediated signals can trigger shedding of lymphocyte L-selectin
    Int. Immunol. 9: 555-562 (1997)

    F. Haag & F. Koch-Nolte (eds):
    ADP-Ribosylation in Animal Tissues: Structure, Function and Biology of Mono(ADPribosyl)transferases and Related Enzymes
    Plenum Press, New York 1997

    A. Hamann (ed):
    Adhesion molecules and chemokines in lymphocte trafficking
    Chur: Harwood Academic Publishers 1997

    F. Koch-Nolte, F. Haag, R. Braren, M. Kühl, R. Girisch, S. Balasubramanian, F. Bazan, & H.G. Thiele:
    Two novel human members of an emerging mammalian gene family related to mono-ADP-ribosylating bacterial toxins
    Genomics 39: 370-376 (1997)

    H.G. Thiele, F. Haag, & F. Nolte:
    In vitro survival and RT6 expression kinetics in peripheral T cells of DP-BB and Lewis rats
    Transpl. Proc. 29: 1681-1683 (1997)

    H.G. Thiele, F. Haag, F. Nolte, C. Lischke & S. Bauschus:
    Expression profiles of RT6 and other T cell surface markers in the black ratRattus rattus
    Transpl. Proc. 29: 1697-1698 (1997)

    F. Haag, F. Koch-Nolte, V. Andresen, S. Karsten, J. Schröder & H.-G. Thiele:
    The rat T-cell differentiation alloantigens RT6.1 and RT6.2 are NAD-metabolizing ecto-enzymes that differ in their enzymatic activities
    Transpl. Proc. 29: 1699-1700 (1997)

    G. Kuhlenbäumer, F. Haag, F. Koch-Nolte & H.-G. Thiele:
    Transcription of the gene for the rat T-cell differentiation marker RT6 in adult rat speen cells is mainly mediated by a promoter 5' of exon 2
    Transpl. Proc. 29: 1701-1702 (1997)

    F. Haag, S. Rothenburg, F. Koch-Nolte & H.-G. Thiele:
    Polymorphic microsatellite within the main promoter region of the rat T-cell differentiation antigen RT6
    Transpl. Proc. 29: 1703-1704 (1997)

    H.G. Thiele, F. Haag, & F. Koch-Nolte:
    Molecular cloning and characterization of the RT6 T-cell mono(ADP-ribosyl)transferases and related enzymes
    Adv. Exp. Med. Biol. 419: 109-120 (1997)

    F. Koch-Nolte & F. Haag :
    Mono(ADP-ribosyl)transferases and related enzymes in animal tissues: emerging gene families
    Adv. Exp. Med. Biol. 419: 1-14 (1997)

    F. Haag & F. Koch-Nolte :
    The Gene Family of Mono(ADP-ribosyl)transferases: Proposal for a Unified Nomenclature
    Adv. Exp. Med. Biol. 419: 459-462 (1997)

    R. Braren, K. Firner, S. Balasubramanian, F. Bazan, H.-G. Thiele, F. Haag, & F. Koch-Nolte:
    Use of the EST database resource to identify and clone novel mono(ADP-ribosyl)transferase gene family members
    Adv. Exp. Med. Biol. 419: 163-168 (1997)

    M. Matthes, H. Bertuleit, C. Hollmann, M. Kühl, H.-G. Thiele, F. Haag, & F. Koch-Nolte:
    'Natural' Rt6-1 and Rt6-2 'knock-out' mice
    Adv. Exp. Med. Biol. 419: 271-274 (1997)

    K Bredehorst, K. Wursthorn, H.-G. Thiele, F. Haag, & F. Koch-Nolte:
    Using secondary structure predictions and Site-directed mutagenesis to probe the role of conserved structural motifs in the RT6 mono(ADP-ribosyl)transferases
    Adv. Exp. Med. Biol. 419: 185-190 (1997)

    S. Karsten, J. Schröder, C. da Silva, A. Guse, D. Kahlke, A. Gerber, H.-G. Thiele, F. Koch-Nolte, & F. Haag
    Expression and comparative analysis of recombinant rat and mouse RT6 T cell mono(ADP-ribosyl)transferases in E.coli
    Adv. Exp. Med. Biol. 419: 175-180 (1997)

    G. Kuhlenbäumer, S. Rothenburg, M. Matthes, C. Hollmann, E. Wingender, H.-G. Thiele, F. Koch-Nolte, & F. Haag
    Expression of the RT6 mono(ADP-ribosyl)transferases is regulated by two promotor regions
    Adv. Exp. Med. Biol. 419: 265-270 (1997)

    F. Bazan & F. Koch-Nolte:
    Sequence and structural links between distant ADP-ribosyltransferase families
    Adv. Exp. Med. Biol. 419: 99-108 (1997)

    W. Tietz and A. Hamann:
    The migratory behavior of murine CD4+ cells of memory phenotype
    Eur. J. Immunol. 27:2225-2232 (1997)

    E. Borges, W. Tietz, M. Steegmaier, T. Moll, R. Hallmann, A. Hamann, D. Vestweber:
    P-selectin glycoprotein ligand-1 (PSGl-1) on T helper 1 but not on T helper 2 cells binds to P-selection and supports migration into inflamed skin
    J. Exp. Med. 185:573-578 (1997)

    A. Hamann (1997):
    Specific trafficking: which cells, which function?
    In: Adhesion molecules and chemokines in lymphocyte trafficking. A. Hamann, ed. Cell adhesion and communication Harwood Academic Publishers, Chur, p.1-19

    A. Hamann, P. Jonas:
    The selectins in lymphocyte homing
    In: The Selectins: Initiators of Leucocyte Endothelial Adhesion". D. Vestveber, eds. Advances In: Vascular Biology Harwood Acad. Publ., Amsterdam, p. 105-115 (1997)

  • F. Koch-Nolte, F. Haag, R. Kastelein & F. Bazan:
    Uncovered: The family relationship of a T cell membrane protein and bacterial toxins
    Immunol. Today 17: 402-406 (1996)

    F. Koch-Nolte, D. Petersen, S. Balasubramanian, R. Kastelein, J.F. Bazan, F. Haag, T. Willer, D. Kahlke, & H.G. Thiele:
    Mouse T cell membrane proteins Rt6-1 and Rt6-2 are arginine/protein mono(ADPribosyl)transferases and share secondary structure motifs with ADP-ribosylating bacterial toxins
    J. Biol. Chem. 271, 7686-7693 (1996)

    F. Haag, G. Kuhlenbäumer, F. Koch-Nolte, E. Wingender, & H.G. Thiele:
    Structure of the gene encoding the rat T cell ecto ADP-ribosyltransferase RT6.2
    J. Immunol. 157: 2022-2030 (1996)

    F. Koch-Nolte, M. Kühl, F. Haag, M. Cetkovich-Cvrlje, E. H. Leiter, & H.-G. Thiele:
    Assignment of the human and mouse genes for muscle ecto-mono(ADPribosyl)transferase to a conserved linkage group on human Chromosme 11p15 and mouse Chromosome 7
    Genomics 36: 215-216 (1996)

    C. Hollmann, F. Haag, M. Schlott, A. Damaske, H. Bertuleit, M. Matthes, M. Kühl, & H.G. Thiele, & F. Koch-Nolte
    Molecular characterization of mouse T-cell ecto ADP-ribosyltransferase Rt6: cloning of a second functional gene and identification of the Rt6 gene products
    Mol. Immunol. 33: 807-818 (1996)

    F. Nolte:
    Mit Cholera- und Diphtherietoxinen verwandte Membranproteine bei Vertebraten
    BIOspektrum 3.96, 43-45 (1996)

    A. Hamann, P. Jonas (1996):
    Lymphcyte migration in vivo: the mouse model
    In: Immunology Methods Manual. I. Lefkovits, eds. Academic Press, p. 1333-1341

    U. Gosslar, P. Jonas, A. Lutz, A. Lifka, D. Naor. A. Hamann, B. Holzmann:
    Predominant role of alpha4-integrins for distinct steps of lymphoma metastasis
    Proc. Natl. Acad. Sci., USA 93:4821-4826 (1996)