- Forschungsgruppenleiterin
Fachgebiete
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Virologie
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Medizinische Mikrobiologie
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Infektiologie
Tätigkeitsschwerpunkte
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Humane Tumorviren: Mechanismen der Pathogenese
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Klinisch relevante humane Polyomaviren: BK Virus; JC Virus und MCPyV
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Metagenomik/Metatranskriptomik zum Nachweis und Identifizierung von Infektionserregern in klinischen Proben
Lebenslauf
Mitgliedschaften
Publikationen
Pregnancy-Related Immune Adaptation Promotes the Emergence of Highly Virulent H1N1 Influenza Virus Strains in Allogenically Pregnant Mice
Engels G, Hierweger A, Hoffmann J, Thieme R, Thiele S, Bertram S, Dreier C, Resa-Infante P, Jacobsen H, Thiele K, Alawi M, Indenbirken D, Grundhoff A, Siebels S, Fischer N, Stojanovska V, Muzzio D, Jensen F, Karimi K, Mittrücker H, Arck P, Gabriel G
CELL HOST MICROBE. 2017;21(3):321-333.
Spontaneous lung metastasis formation of human Merkel cell carcinoma cell lines transplanted into scid mice
Knips J, Czech-Sioli M, Spohn M, Heiland M, Moll I, Grundhoff A, Schumacher U, Fischer N
INT J CANCER. 2017;141(1):160-171.
Pegivirus Infection in Domestic Pigs, Germany
Baechlein C, Grundhoff A, Fischer N, Alawi M, Hoeltig D, Waldmann K, Becher P
EMERG INFECT DIS. 2016;22(7):1312-4.
Suspected encephalitis with Candida tropicalis and Fusarium detected by unbiased RNA sequencing
Christopeit M, Grundhoff A, Rohde H, Belmar-Campos C, Grzyska U, Fiehler J, Wolschke C, Kröger N, Fischer N
ANN HEMATOL. 2016;95(11):1919-1921.
Investigation of Viral and Host Chromatin by ChIP-PCR or ChIP-Seq Analysis
Günther T, Theiss J, Fischer N, Grundhoff A
Curr Protoc Microbiol. 2016;40:1E.10.1-1E.10.21.
Multicenter quality assessment of 16S ribosomal DNA-sequencing for microbiome analyses reveals high inter-center variability
Hiergeist A, Reischl U, , Gessner A
INT J MED MICROBIOL. 2016;306(5):334-42.
Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney
Krebs C, Paust H, Krohn S, Koyro T, Brix S, Riedel J, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch C, Mittrücker H, Steinhoff U, Stockinger B, Perez L, Wenzel U, Janneck M, Steinmetz O, Gagliani N, Stahl R, Huber S, Turner J, Panzer U
IMMUNITY. 2016;45(5):1078-1092.
Replication of merkel cell polyomavirus induces reorganization of promyelocytic leukemia nuclear bodies
Neumann F, Czech-Sioli M, Dobner T, Grundhoff A, Schreiner S, Fischer N
J GEN VIROL. 2016;97(11):2926-2938.
Frequent presence of hepaci and pegiviruses in commercial equine serum pools
Postel A, Cavalleri J, Pfaender S, Walter S, Steinmann E, Fischer N, Feige K, Haas L, Becher P
VET MICROBIOL. 2016;182:8-14.
Presence of atypical porcine pestivirus (APPV) genomes in newborn piglets correlates with congenital tremor
Postel A, Hansmann F, Baechlein C, Fischer N, Alawi M, Grundhoff A, Derking S, Tenhündfeld J, Pfankuche V, Herder V, Baumgärtner W, Wendt M, Becher P
SCI REP-UK. 2016;6:27735.
Tropheryma whipplei in children with diarrhoea in rural Ghana
Vinnemeier C, Klupp E, Krumkamp R, Rolling T, Fischer N, Owusu-Dabo E, Addo M, Adu-Sarkodie Y, Käsmaier J, Aepfelbacher M, Cramer J, May J, Tannich E
CLIN MICROBIOL INFEC. 2016;22(1):65.e1 - 65.e3.
Highly divergent hepaciviruses from African cattle
Corman V, Grundhoff A, Baechlein C, Fischer N, Gmyl A, Wollny R, Dei D, Ritz D, Binger T, Adankwah E, Marfo K, Annison L, Annan A, Adu-Sarkodie Y, Oppong S, Becher P, Drosten C, Drexler J
J VIROL. 2015;89(11):5876-82.
Identification of a Novel Hepacivirus in Domestic Cattle from Germany
Fischer N, Baechlein C, Grundhoff A, Alawi M, Indenbirken D, Postel A, Baron A, Offinger J, Becker K, Beineke A, Rehage J, Becher P
J VIROL. 2015;89(14):7007-15.
Evaluation of Unbiased Next-Generation Sequencing of RNA (RNA-seq) as a Diagnostic Method in Influenza Virus-Positive Respiratory Samples
Fischer N, Indenbirken D, Meyer T, Lütgehetmann M, Lellek H, Spohn M, Aepfelbacher M, Alawi M, Grundhoff A
J CLIN MICROBIOL. 2015;53(7):2238-50.
Merkel cell polyomavirus, a highly prevalent virus with tumorigenic potential
Grundhoff A, Fischer N
Curr Opin Virol. 2015;14:129-137.
In Vitro Replication Assay for Merkel Cell Polyomavirus (MCPyV)
Neumann F, Czech-Sioli M, Grundhoff A, Fischer N
Curr Protoc Microbiol. 2015;38:14F.2.1-14F.2.19.
Close relationship of ruminant pestiviruses and classical Swine Fever virus
Postel A, Schmeiser S, Oguzoglu T, Indenbirken D, Alawi M, Fischer N, Grundhoff A, Becher P
EMERG INFECT DIS. 2015;21(4):668-72.
A Comprehensive Analysis of Replicating Merkel Cell Polyomavirus Genomes Delineates the Viral Transcription Program and Suggests a Role for mcv-miR-M1 in Episomal Persistence
Theiss J, Günther T, Alawi M, Neumann F, Tessmer U, Fischer N, Grundhoff A
PLOS PATHOG. 2015;11(7):e1004974.
Complete Genome Sequence of Bovine Pestivirus Strain PG-2, a Second Member of the Tentative Pestivirus Species Giraffe
Becher P, Fischer N, Grundhoff A, Stalder H, Schweizer M, Postel A
Genome Announc. 2014;2(3):.
High-affinity Rb Binding, p53 Inhibition, Subcellular Localization, and Transformation by Wild-Type or Tumor-Derived Shortened Merkel Cell Polyomavirus Large T Antigens
Borchert S, Czech-Sioli M, Neumann F, Schmidt C, Wimmer P, Dobner T, Grundhoff A, Fischer N
J VIROL. 2014;88(6):3144-60.
Merkel Cell Polyomavirus
Fischer N, Adam G
2014. Cancers in People with HIV and AIDS. Yarchoan R (Hrsg.). 1. Aufl. Springer, 113-122.
Nachweis von Bakterien, Pilzen und Viren im Hochdurchsatz
Fischer N, Grundhoff A
BioSpektrum. 2014;20(5):524-527.
Rapid Metagenomic Diagnostics for Suspected Outbreak of Severe Pneumonia
Fischer N, Rohde H, Indenbirken D, Günther T, Reumann K, Lütgehetmann M, Meyer T, Kluge S, Aepfelbacher M, Alawi M, Grundhoff A
EMERG INFECT DIS. 2014;20(6):1072-5.
Merkel cell polyomavirus detection in Merkel cell cancer tumors in Northern Germany using PCR and protein expression
Leitz M, Stieler K, Grundhoff A, Moll I, Brandner J, Fischer N
J MED VIROL. 2014;86 (10):1813-1819.
Complete Genome Sequence of Pronghorn Virus, a Pestivirus.
Neill J, Ridpath J, Fischer N, Grundhoff A, Postel A, Becher P
Genome Announc. 2014;2(3):e00575-14.
Utilization of replication-competent XMRV reporter-viruses reveals severe viral restriction in primary human cells
Stürzel C, Palesch D, Khalid M, Wissing S, Fischer N, Münch J
PLOS ONE. 2013;8(9):e74427.
In-depth investigation of archival and prospectively collected samples reveals no evidence for XMRV infection in prostate cancer.
Lee D, Jaydip D, Gaughan C, Steffen I, Tang N, Luk K, Qiu X, Urisman A, Fischer N, Molinaro R, Broz M, Schochetman G, Klein E, Ganem D, Derisi J, Simmons G, Hackett J, Silverman R, Chiu C
PLOS ONE. 2012;7(9):44954.
XMRV induces cell migration, cytokine expression and tumor angiogenesis: are 22Rv1 cells a suitable prostate cancer model?
Stieler K, Schumacher U, Horst A, Fischer N
PLOS ONE. 2012;7(7):42321.
S100A7/psoriasin expression in the human lung: unchanged in patients with COPD, but upregulated upon positive S. aureus detection.
Andresen E, Lange C, Strodthoff D, Goldmann T, Fischer N, Sahly H, Branscheid D, Heine H
BMC PULM MED. 2011;11:10.
Replication, gene expression and particle production by a consensus Merkel Cell Polyomavirus (MCPyV) genome.
Neumann F, Borchert S, Schmidt C, Reimer R, Hohenberg H, Fischer N, Grundhoff A
PLOS ONE. 2011;6(12):29112.
No detection of XMRV in blood samples and tissue sections from prostate cancer patients in Northern Europe.
Stieler K, Schindler S, Schlomm T, Hohn O, Bannert N, Simon R, Minner S, Schindler M, Fischer N
PLOS ONE. 2011;6(10):25592.
Detection of Merkel cell polyomavirus (MCPyV) in Merkel cell carcinoma cell lines
Fischer N, Brandner J, Fuchs F, Moll I, Grundhoff A
INT J CANCER. 2010;126(9):2133-42.
Xenotropic murine leukemia virus-related gammaretrovirus in respiratory tract.
Fischer N, Schulz C, Stieler K, Hohn O, Lange C, Drosten C, Aepfelbacher M
EMERG INFECT DIS. 2010;16(6):1000-1002.
Apobec 3G efficiently reduces infectivity of the human exogenous gammaretrovirus XMRV.
Stieler K, Fischer N
PLOS ONE. 2010;5(7):11738.
Host range and cellular tropism of the human exogenous gammaretrovirus XMRV.
Stieler K, Schulz C, Lavanya M, Aepfelbacher M, Stocking C, Fischer N
VIROLOGY. 2010;399(1):23-30.
Detection of Merkel cell polyomavirus (MCPyV) in Merkel cell carcinoma cell lines: Cell morphology and growth phenotype do not reflect presence of the virus
Fischer N, Brandner J, Fuchs F, Moll I, Adam G
INT J CANCER. 2009;126(9):2133-2142.
Prevalence of human gammaretrovirus XMRV in sporadic prostate cancer.
Fischer N, Hellwinkel O, Schulz C, Chun F, Huland H, Aepfelbacher M, Schlomm T
J CLIN VIROL. 2008;43(3):277-283.
Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant.
Urisman A, Molinaro R, Fischer N, Plummer S, Casey G, Klein E, Malathi K, Magi-Galluzzi C, Tubbs R, Ganem D, Silverman R, DeRisi J
PLOS PATHOG. 2006;2(3):25.
Yeast poly(A)-binding protein Pab1 shuttles between the nucleus and the cytoplasm and functions in mRNA export.
Brune C, Munchel S, Fischer N, Podtelejnikov A, Weis K
RNA. 2005;11(4):517-531.
The DEAD box protein Dhh1 stimulates the decapping enzyme Dcp1.
Fischer N, Weis K
EMBO J. 2002;21(11):2788-2797.
Functional analysis of different LMP1 proteins isolated from Epstein-Barr virus-positive carriers.
Fischer N, Kopper B, Graf N, Schlehofer J, Grässer F, Mueller-Lantzsch N
VIRUS RES. 1999;60(1):41-54.
A potential NES of the Epstein-Barr virus nuclear antigen 1 (EBNA1) does not confer shuttling.
Fischer N, Voss M, Mueller-Lantzsch N, Grässer F
FEBS LETT. 1999;447(2-3):311-314.
Isolation and analysis of two strongly transforming isoforms of the Epstein-Barr-Virus(EBV)-encoded latent membrane protein-1 (LMP1) from a single Hodgkin's lymphoma.
Mehl A, Fischer N, Rowe M, Hartmann F, Daus H, Trümper L, Pfreundschuh M, Müller-Lantzsch N, Grässer F
INT J CANCER. 1998;76(2):194-200.
Epstein-Barr virus nuclear antigen 1 forms a complex with the nuclear transporter karyopherin alpha2.
Fischer N, Kremmer E, Lautscham G, Mueller-Lantzsch N, Grässer F
J BIOL CHEM. 1997;272(7):3999-4005.
Letzte Aktualisierung aus dem FIS: 17.07.2017 - 00:04 Uhr