Immunofluorescent Staining for the Detection of the Hepatitis B Core Antigen in Frozen Liver Sections of Human Liver Chimeric Mice
Allweiss L, Lütgehetmann M, Dandri-Petersen M
2017. Hepatitis B Virus. 135-142.

Proliferation of primary human hepatocytes and prevention of hepatitis B virus reinfection efficiently deplete nuclear cccDNA in vivo
Allweiss L, Volz T, Giersch K, Kah J, Raffa G, Petersen J, Lohse A, Beninati C, Pollicino T, Urban S, Lütgehetmann M, Dandri M
GUT. 2017 [Epub ahead of print].

Dose-dependent T-cell Dynamics and Cytokine Cascade Following rVSV-ZEBOV Immunization
Dahlke C, Kasonta R, Lunemann S, Krähling V, Zinser M, Biedenkopf N, Fehling S, Ly M, Rechtien A, Stubbe H, Olearo F, Borregaard S, Jambrecina A, Stahl F, Strecker T, Eickmann M, Lütgehetmann M, Spohn M, Schmiedel S, Lohse A, Becker S, Addo M
EBioMedicine. 2017;19:107-118.

Serum HBV pgRNA as a clinical marker for cccDNA activity
Giersch K, Allweiss L, Volz T, Dandri-Petersen M, Lütgehetmann M
J HEPATOL. 2017;66(2):460-462.

Both interferon alpha and lambda can reduce all intrahepatic HDV infection markers in HBV/HDV infected humanized mice
Giersch K, Homs M, Volz T, Helbig M, Allweiss L, Lohse A, Petersen J, Buti M, Pollicino T, Sureau C, Dandri M, Lütgehetmann M
SCI REP-UK. 2017;7(1):3757.

High clinical manifestation rate in an imported outbreak of hepatitis E genotype 1 infection in a German group of travellers returning from India
Pischke S, Schulze zur Wiesch J, Lütgehetmann M, Kreuels B, Lüth S, Kapaun P, Benten D, Schmiedel S, Sterneck M, Lohse A, Polywka S
ANN HEPATOL. 2017;16(1):57-62.

Human liver chimeric mice as a new model of chronic hepatitis E virus infection and preclinical drug evaluation
Allweiss L, Gass S, Giersch K, Groth A, Kah J, Volz T, Rapp G, Schöbel A, Lohse A, Polywka S, Pischke S, Herker E, Dandri-Petersen M, Lütgehetmann M
J HEPATOL. 2016;64(5):1033-1040.

Primary Human Hepatocytes Repopulate Livers of Mice After In Vitro Culturing and Lentiviral-Mediated Gene Transfer
Bierwolf J, Volz T, Lütgehetmann M, Allweiss L, Riecken K, Warlich M, Fehse B, Kalff J, Dandri-Petersen M, Pollok J
TISSUE ENG. 2016;22(9-10):742-53.

Efficacy and safety of sofosbuvir/ledipasvir for the treatment of patients with hepatitis C virus re-infection after liver transplantation
Ciesek S, Proske V, Otto B, Pischke S, Costa R, Lütgehetmann M, Polywka S, Klempnauer J, Nashan B, Manns M, von Hahn T, Lohse A, Wedemeyer H, Mix H, Sterneck M
TRANSPL INFECT DIS. 2016;18(3):326-32.

Heme oxygenase-1 polymorphisms can affect HCV replication and treatment responses with different efficacy in humanized mice
Kah J, Volz T, Lütgehetmann M, Groth A, Lohse A, Tiegs G, Sass G, Dandri-Petersen M
LIVER INT. 2016 [Epub ahead of print].

Attenuated viral hepatitis in Trem1-/- mice is associated with reduced inflammatory activity of neutrophils
Kozik J, Trautmann T, Carambia A, Preti M, Lütgehetmann M, Krech T, Wiegard C, Heeren J, Herkel J
SCI REP-UK. 2016;6:28556.

Kinetics of HIV-1 latency reversal quantified on the single cell level using a novel flow-based technique
Martrus G, Niehrs A, Cornelis R, Rechtien A, García-Beltran W, Lütgehetmann M, Hoffmann C, Altfeld M
J VIROL. 2016;90(20):9018-9028.

Variability in long-term hepatitis B virus dynamics under antiviral therapy
Murray J, Stancevic O, Lütgehetmann M, Wursthorn K, Petersen J, Dandri-Petersen M
J THEOR BIOL. 2016;391:74-80.

Blood-borne Hepatitis E Virus Transmission: A Relevant Risk for Immunosuppressed Patients
Pischke S, Hiller J, Lütgehetmann M, Polywka S, Rybczynski M, Ayuketang F, Lohse A
CLIN INFECT DIS. 2016;63(4):569-570.

Changes in HIV-1 Capsid Stability Induced by Common Cytotoxic-T-Lymphocyte-Driven Viral Sequence Mutations
Schommers P, Martrus G, Matschl U, Sirignano M, Lütgehetmann M, Richert L, Hope T, Fätkenheuer G, Altfeld M
J VIROL. 2016;90(16):7579-86.

Experimental Models: Cell Culture and Animal Models
Dandri-Petersen M, Volz T, Lütgehetmann M
2015. Hepatitis B Virus in Human Diseases . Liaw Y, Zoulim F (Hrsg.). 1. Aufl. Springer International Publishing, 35-62.

Evaluation of Unbiased Next-Generation Sequencing of RNA (RNA-seq) as a Diagnostic Method in Influenza Virus-Positive Respiratory Samples
Fischer N, Indenbirken D, Meyer T, Lütgehetmann M, Lellek H, Spohn M, Aepfelbacher M, Alawi M, Grundhoff A
J CLIN MICROBIOL. 2015;53(7):2238-50.

Relevance of chronic hepatitis E in liver transplant recipients: a real-life setting
Galante A, Pischke S, Polywka S, Lütgehetmann M, Suneetha P, Gisa A, Hiller J, Dienes H, Nashan B, Lohse A, Sterneck M
TRANSPL INFECT DIS. 2015;17(4):617-22.

Hepatitis Delta co-infection in humanized mice leads to pronounced induction of innate immune responses in comparison to HBV mono-infection
Giersch K, Allweiss L, Volz T, Helbig M, Bierwolf J, Lohse A, Pollok J, Petersen J, Dandri-Petersen M, Lütgehetmann M
J HEPATOL. 2015;63(2):346-53.

Comparison of autochthonous and imported cases of hepatitis A or hepatitis E
Hartl J, Kreuels B, Polywka S, Addo M, Lütgehetmann M, Dandri-Petersen M, Dammermann W, Sterneck M, Lohse A, Pischke S
Z GASTROENTEROL. 2015;53(7):639-643.

Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody
Mailly L, Xiao F, Lupberger J, Wilson G, Aubert P, Duong F, Calabrese D, Leboeuf C, Fofana I, Thumann C, Bandiera S, Lütgehetmann M, Volz T, Davis C, Harris H, Mee C, Girardi E, Chane-Woon-Ming B, Ericsson M, Fletcher N, Bartenschlager R, Pessaux P, Vercauteren K, Meuleman P, Villa P, Kaderali L, Pfeffer S, Heim M, Neunlist M, Zeisel M, Dandri-Petersen M, McKeating J, Robinet E, Baumert T
NAT BIOTECHNOL. 2015;33(5):549-54.

Association of hepatitis E virus and essential cryoglobulinemia?
Pischke S, Polywka S, Haag F, Iking-Konert C, Sterneck M, Lütgehetmann M, Dammermann W, Lüth S, Schirmer J
J CLIN VIROL. 2015;67:23-24.

Immune cell responses are not required to induce substantial hepatitis B virus antigen decline during pegylated interferon-alpha administration
Allweiss L, Volz T, Lütgehetmann M, Giersch K, Bornscheuer T, Lohse A, Petersen J, Ma H, Klumpp K, Fletcher S, Dandri M
J HEPATOL. 2014;60(3):500-7.

Mouse models of hepatitis B and delta virus infection
Dandri M, Lütgehetmann M
J IMMUNOL METHODS. 2014;410:39-49.

Rapid Metagenomic Diagnostics for Suspected Outbreak of Severe Pneumonia
Fischer N, Rohde H, Indenbirken D, Günther T, Reumann K, Lütgehetmann M, Meyer T, Kluge S, Aepfelbacher M, Alawi M, Grundhoff A
EMERG INFECT DIS. 2014;20(6):1072-5.

Persistent hepatitis D virus mono-infection in humanized mice is efficiently converted by hepatitis B virus to a productive co-infection
Giersch K, Helbig M, Volz T, Allweiss L, Mancke L, Lohse A, Polywka S, Pollok J, Petersen J, Taylor J, Dandri M, Lütgehetmann M
J HEPATOL. 2014;60(3):538-44.

Relevance of a Full-Length Genomic RNA Standard and a Thermal-Shock Step for Optimal Hepatitis Delta Virus Quantification
Homs M, Giersch K, Blasi M, Lütgehetmann M, Buti M, Esteban R, Dandri M, Rodriguez-Frias F
J CLIN MICROBIOL. 2014;52(9):3334-8.

Improved Detection of Bacterial Central Nervous System Infections by Use of a Broad-Range PCR Assay
Meyer T, Franke G, Polywka S, Lütgehetmann M, Gbadamosi J, Magnus T, Aepfelbacher M
J CLIN MICROBIOL. 2014;52(5):1751-3.

Binding of hepatitis B virus to its cellular receptor alters the expression profile of genes of bile acid metabolism
Oehler N, Volz T, Bhadra O, Kah J, Allweiss L, Giersch K, Bierwolf J, Riecken K, Pollok J, Lohse A, Fehse B, Petersen J, Urban S, Lütgehetmann M, Heeren J, Dandri M
HEPATOLOGY. 2014.

New foe treated with old guns - supportive role of steroids in the treatment of acute severe hepatitis E
Sebode M, Pischke S, Lütgehetmann M, Polywka S, Quaas A, Lohse A, Wege H
BMC GASTROENTEROL. 2014;14(191):.

Experimental models and therapeutic approaches for HBV
Dandri M, Lütgehetmann M, Petersen J
SEMIN IMMUNOPATHOL. 2013;35(1):7-21.

Herpes simplex virus-1 encephalitis can trigger anti-NMDA receptor encephalitis: case report
Leypoldt F, Titulaer M, Aguilar E, Walther J, Bönstrup M, Havemeister S, Teegen B, Lütgehetmann M, Rosenkranz M, Magnus T, Dalmau J
NEUROLOGY. 2013;81(18):1637-9.

The entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized mice previously infected with hepatitis B virus
Volz T, Allweiss L, Ben MBarek M, Warlich M, Lohse A, Pollok J, Alexandrov A, Urban S, Petersen J, Lütgehetmann M, Dandri M
J HEPATOL. 2013;58(5):861-7.

Primary human hepatocytes from metabolic-disordered children recreate highly differentiated liver-tissue-like spheroids on alginate scaffolds.
Bierwolf J, Lütgehetmann M, Deichmann S, Erbes J, Volz T, Dandri-Petersen M, Cohen S, Nashan B, Pollok J
TISSUE ENG. 2012;18(13-14):1443-1453.

Humanized chimeric uPA mouse model for the study of hepatitis B and D virus interactions and preclinical drug evaluation.
Lütgehetmann M, Mancke L, Volz T, Helbig M, Allweiss L, Bornscheuer T, Pollok J, Lohse A, Petersen J, Urban S, Dandri-Petersen M
HEPATOLOGY. 2012;55(3):685-694.

Entecavir plus tenofovir combination as rescue therapy in pre-treated chronic hepatitis B patients
Petersen J, Ratziu V, Buti M, Janssen H, Brown A, Lampertico P, Schollmeyer J, Zoulim F, Wedemeyer H, Sterneck M, Berg T, Sarrazin C, Lutgehetmann M, Buggisch P
J HEPATOL. 2012;56(3):520-6.

Entecavir plus tenofovir combination as rescue therapy in pre-treated chronic hepatitis B patients: an international multicenter cohort study.
Petersen J, Ratziu V, Buti M, Janssen H, Brown A, Lampertico P, Schollmeyer J, Zoulim F, Wedemeyer H, Sterneck M, Berg T, Sarrazin C, Lütgehetmann M, Buggisch P
J HEPATOL. 2012;56(3):520-526.

Strong antiviral activity of the new l-hydroxycytidine derivative, l-Hyd4FC, in HBV-infected human chimeric uPA/SCID mice.
Volz T, Lütgehetmann M, Allweiss L, Warlich M, Bierwolf J, Pollok J, Petersen J, Matthes E, Dandri-Petersen M
ANTIVIR THER. 2012;17(4):623-631.

Primary rat hepatocyte culture on 3D nanofibrous polymer scaffolds for toxicology and pharmaceutical research.
Bierwolf J, Lütgehetmann M, Feng K, Erbes J, Deichmann S, Toronyi E, Stieglitz C, Nashan B, Ma P, Pollok J
BIOTECHNOL BIOENG. 2011;108(1):141-150.

Hepatitis B virus limits response of human hepatocytes to interferon-α in chimeric mice.
Lütgehetmann M, Bornscheuer T, Volz T, Allweiss L, Bockmann J, Pollok J, Lohse A, Petersen J, Dandri-Petersen M
GASTROENTEROLOGY. 2011;140(7):1-2, 2074-2083.

Desperately seeking diarrhoea: outbreak of haemolytic uraemic syndrome caused by emerging sorbitol-fermenting shiga toxin-producing Escherichia coli O157:H-, Germany, 2009.
Nielsen S, Frank C, Fruth A, Spode A, Prager R, Graff A, Plenge-Bönig A, Loos S, Lütgehetmann M, Kemper M, Müller-Wiefel D, Werber D
ZOONOSES PUBLIC HLTH. 2011;58(8):567-572.

RGB marking facilitates multicolor clonal cell tracking.
Riecken K, Thomaschewski M, Warlich M, Volz T, Cornils K, Niebuhr B, Täger M, Lütgehetmann M, Pollok J, Stocking C, Dandri-Petersen M, Benten D, Fehse B
NAT MED. 2011;17(4):504-509.

Primary human hepatocytes on biodegradable poly(l-lactic acid) matrices: a promising model for improving transplantation efficiency with tissue engineering.
Török-Pollok E, Lütgehetmann M, Bierwolf J, Melbeck S, Düllmann J, Nashan B, Ma P, Pollok J
LIVER TRANSPLANT. 2011;17(2):104-114.

Forced activation of β-catenin signaling supports the transformation of hTERT-immortalized human fetal hepatocytes.
Wege H, Heim D, Lütgehetmann M, Dierlamm J, Lohse A, Brümmendorf T
MOL CANCER RES. 2011;9(9):1222-1231.

Entecavir treatment for chronic hepatitis B
Zoutendijk R, Reijnders J, Brown A, Zoulim F, Mutimer D, Deterding K, Petersen J, Hofmann W, Buti M, Santantonio T, van Bömmel F, Pradat P, Oo Y, Lütgehetmann M, Berg T, Hansen B, Wedemeyer H, Janssen H
HEPATOLOGY. 2011;54(2):443-51.

Wissensstand, Präventionsverhalten und Therapieadhärenz von Patienten mit chronischer Hepatitis B in einem großen tertiären Zentrum in Deutschland
Lutgehetmann M, Meyer F, Volz T, Lohse A, Fischer C, Dandri M, Petersen J
Z GASTROENTEROL. 2010;48(9):1126-32.

[Knowledge about HBV, prevention behaviour and treatment adherence of patients with chronic hepatitis B in a large referral centre in Germany].
Lütgehetmann M, Meyer F, Volz T, Lohse A, Fischer C, Dandri-Petersen M, Petersen J
Z GASTROENTEROL. 2010;48(9):1126-1132.

In vivo proliferation of hepadnavirus-infected hepatocytes induces loss of covalently closed circular DNA in mice.
Lütgehetmann M, Volz T, Köpke A, Broja T, Tigges E, Lohse A, Fuchs E, Murray J, Petersen J, Dandri-Petersen M
HEPATOLOGY. 2010;52(1):16-24.

Virion half-life in chronic hepatitis B infection is strongly correlated with levels of viremia.
Dandri-Petersen M, Murray J, Lütgehetmann M, Volz T, Lohse A, Petersen J
HEPATOLOGY. 2008;48(4):1079-1086.

Sequential combination therapy leads to biochemical and histological improvement despite low ongoing intrahepatic hepatitis B virus replication.
Lütgehetmann M, Volz T, Quaas A, Zankel M, Fischer C, Dandri-Petersen M, Petersen J
ANTIVIR THER. 2008;13(1):57-66.

Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein.
Petersen J, Dandri-Petersen M, Mier W, Lütgehetmann M, Volz T, von Weizsäcker F, Haberkorn U, Fischer L, Pollok J, Erbes B, Seitz S, Urban S
NAT BIOTECHNOL. 2008;26(3):335-341.

Impaired intrahepatic hepatitis B virus productivity contributes to low viremia in most HBeAg-negative patients.
Volz T, Lütgehetmann M, Wachtler P, Jacob A, Quaas A, Murray J, Dandri-Petersen M, Petersen J
GASTROENTEROLOGY. 2007;133(3):843-852.

Small animal model systems for studying hepatitis B virus replication and pathogenesis.
Dandri-Petersen M, Lütgehetmann M, Volz T, Petersen J
SEMIN LIVER DIS. 2006;26(2):181-191.

Morphological and functional analysis of rat hepatocyte spheroids generated on poly(L-lactic acid) polymer in a pulsatile flow bioreactor.
Török E, Vogel C, Lütgehetmann M, Ma P, Dandri-Petersen M, Petersen J, Burda M, Siebert K, Düllmann J, Rogiers X, Pollok J
TISSUE ENG. 2006;12(7):1881-1890.

Temporary HBV resolution in an HIV-coinfected patient during HBV-directed combination therapy followed by relapse of HBV.
Wursthorn K, Buggisch P, Lütgehetmann M, Zollner B, Petersen J
ANTIVIR THER. 2006;11(5):647-652.

Peginterferon alpha-2b plus adefovir induce strong cccDNA decline and HBsAg reduction in patients with chronic hepatitis B.
Wursthorn K, Lütgehetmann M, Dandri-Petersen M, Volz T, Buggisch P, Zollner B, Longerich T, Schirmacher P, Metzler F, Zankel M, Fischer C, Currie G, Brosgart C, Petersen J
HEPATOLOGY. 2006;44(3):675-684.

Animal models for the study of HBV replication and its variants.
Dandri-Petersen M, Volz T, Lütgehetmann M, Petersen J
J CLIN VIROL. 2005;34(1):54-62.

The liver stage of Plasmodium berghei inhibits host cell apoptosis.
van de Sand C, Horstmann S, Schmidt A, Sturm A, Bolte S, Krueger A, Lütgehetmann M, Pollok J, Libert C, Heussler V
MOL MICROBIOL. 2005;58(3):731-742.

Letzte Aktualisierung aus dem FIS: 17.07.2017 - 00:04 Uhr