AXL BLOCKADE BY BGB324 INHIBITS BCR-ABL TYROSINE KINASE INHIBITOR-SENSITIVE AND -RESISTANT CHRONIC MYELOID LEUKEMIA
Ben Batalla I, Erdmann R, Jørgensen H, Mitchell R, Ernst T, von Amsberg G, Schafhausen P, Velthaus J, Rankin S, Clark R, Koschmieder S, Schultze A, Mitra S, Vandenberghe P, Brümmendorf T, Carmeliet P, Hochhaus A, Pantel K, Bokemeyer C, Helgason G, Holyoake T, Loges S
CLIN CANCER RES. 2017;23(9):2289-2300.

The marine triterpene glycoside frondoside A induces p53-independent apoptosis and inhibits autophagy in urothelial carcinoma cells
Dyshlovoy S, Madanchi R, Hauschild J, Otte K, Alsdorf W, Schumacher U, Kalinin V, Silchenko A, Avilov S, Honecker F, Stonik V, Bokemeyer C, von Amsberg G
BMC CANCER. 2017;17(1):93.

A nonrandomized, prospective, clinical study on the impact of circulating tumor cells on outcomes of urothelial carcinoma of the bladder patients treated with radical cystectomy with or without adjuvant chemotherapy
Soave A, Riethdorf S, Dahlem R, von Amsberg G, Minner S, Weisbach L, Engel O, Fisch M, Pantel K, Rink M
INT J CANCER. 2017;140(2):381-389.

The marine triterpene glycoside frondoside A exhibits activity in vitro and in vivo in prostate cancer
Dyshlovoy S, Menchinskaya E, Venz S, Rast S, Amann K, Hauschild J, Otte K, Kalinin V, Silchenko A, Avilov S, Alsdorf W, Madanchi R, Bokemeyer C, Schumacher U, Walther R, Aminin D, Fedorov S, Shubina L, Stonik V, Balabanov S, Honecker F, von Amsberg G
INT J CANCER. 2016;138(10):2450-65.

Marine compound rhizochalinin shows high in vitro and in vivo efficacy in castration resistant prostate cancer
Dyshlovoy S, Otte K, Alsdorf W, Hauschild J, Lange T, Venz S, Bauer C, Bähring R, Amann K, Mandanchi R, Schumacher U, Schröder-Schwarz J, Makarieva T, Guzii A, Tabakmakher K, Fedorov S, Shubina L, Kasheverov I, Ehmke H, Steuber T, Stonik V, Bokemeyer C, Honecker F, von Amsberg G
ONCOTARGET. 2016;7(43):69703 - 69717.

Guanidine Alkaloids from the Marine Sponge Monanchora pulchra Show Cytotoxic Properties and Prevent EGF-Induced Neoplastic Transformation in Vitro
Dyshlovoy S, Tabakmakher K, Hauschild J, Shchekaleva R, Otte K, Guzii A, Makarieva T, Kudryashova E, Fedorov S, Shubina L, Bokemeyer C, Honecker F, Stonik V, von Amsberg G
MAR DRUGS. 2016;14(7):E133.

Anti-migratory activity of marine alkaloid monanchocidin A - proteomics-based discovery and confirmation
Dyshlovoy S, Venz S, Hauschild J, Tabakmakher K, Otte K, Madanchi R, Walther R, Guzii A, Makarieva T, Shubina L, Fedorov S, Stonik V, Bokemeyer C, Balabanov S, Honecker F, von Amsberg G
PROTEOMICS. 2016;16(10):1590-603.

Cabazitaxel overcomes cisplatin resistance in germ cell tumour cells
Gerwing M, Jacobsen C, Dyshlovoy S, Hauschild J, Rohlfing T, Oing C, Venz S, Oldenburg J, Oechsle K, Bokemeyer C, von Amsberg G, Honecker F
J CANCER RES CLIN. 2016;142(9):1979-94.

Melonoside A: An ω-Glycosylated Fatty Acid Amide from the Far Eastern Marine Sponge Melonanchora kobjakovae
Guzii A, Makarieva T, Denisenko V, Dmitrenok P, Kuzmich A, Dyshlovoy S, von Amsberg G, Krasokhin V, Stonik V
ORG LETT. 2016;18(14):3478-81.

Platinum-refractory germ cell tumors
Oing C, Alsdorf W, von Amsberg G, Oechsle K, Bokemeyer C
WORLD J UROL. 2016 [Epub ahead of print].

Second Line Chemotherapy for Advanced and Metastatic Urothelial Carcinoma: Vinflunine and Beyond-A Comprehensive Review of the Current Literature
Oing C, Rink M, Oechsle K, Seidel C, von Amsberg G, Bokemeyer C
J UROLOGY. 2016;195(2):254-63.

Pharmacotherapeutic treatment of germ cell tumors - standard of care and recent developments
Oing C, Seidel C, von Amsberg G, Oechsle K, Bokemeyer C
EXPERT OPIN PHARMACO. 2016;17(4):545-60.

Absolute Configuration and Body Part Distribution of the Alkaloid 6-epi-Monanchorin from the Marine Polychaete Chaetopterus variopedatus
Shubina L, Makarieva T, Denisenko V, Dmitrenok P, Dyshlovoy S, von Amsberg G, Glazunov V, Silchenko A, Stonik V
NAT PROD COMMUN. 2016;11(9):1253-1257.

Pallidopenillines: Polyketides from the Alga-Derived Fungus Penicillium thomii Maire KMM 4675
Sobolevskaya M, Leshchenko E, Hoai T, Denisenko V, Dyshlovoy S, Kirichuk N, Khudyakova Y, Kim N, Berdyshev D, Pislyagin E, Kuzmich A, Gerasimenko A, Popov R, von Amsberg G, Antonov A, Afiyatullov S
J NAT PROD. 2016;79(12):3031-3038.

Activity of nintedanib in germ cell tumors
Steinemann G, Jacobsen C, Gerwing M, Hauschild J, Amsberg G, Höpfner M, Nitzsche B, Honecker F
ANTI-CANCER DRUG. 2016;27(2):89-98.

Fortschritte in der Therapie urogenitaler Tumoren
von Amsberg G, Bokemeyer C
Im Focus Onkologie. 2016;19(7-8):64.

Pretrichodermamides D-F from a Marine Algicolous Fungus Penicillium sp. KMM 4672
Yurchenko A, Smetanina O, Ivanets E, Kalinovsky A, Khudyakova Y, Kirichuk N, Popov R, Bokemeyer C, von Amsberg G, Chingizova E, Afiyatullov S, Dyshlovoy S
MAR DRUGS. 2016;14(7):E122.

Marine alkaloid Monanchocidin a overcomes drug resistance by induction of autophagy and lysosomal membrane permeabilization
Dyshlovoy S, Hauschild J, Amann K, Tabakmakher K, Venz S, Walther R, Guzii A, Makarieva T, Shubina L, Fedorov S, Stonik V, Bokemeyer C, Balabanov S, Honecker F, Amsberg G
ONCOTARGET. 2015;6(19):17328-41.

Systemic treatment of vulvar cancer
Mahner S, Prieske K, Grimm D, Trillsch F, Prieske S, von Amsberg G, Petersen C, Müller V, Jänicke F, Woelber L
EXPERT REV ANTICANC. 2015;15(6):629-37.

Beyond Bevacizumab: An Outlook to New Anti-Angiogenics for the Treatment of Ovarian Cancer
Mahner S, Woelber L, Müller V, Witzel I, Prieske K, Grimm D, von Amsberg G, Trillsch F
Front Oncol. 2015;5:211.

Management of advanced bladder cancer in the era of targeted therapies
Soave A, Engel O, von Amsberg G, Becker A, Dahlem R, Shariat S, Fisch M, Rink M
MINERVA UROL NEFROL. 2015;67(2):103-15.

Viele innovative Substanzen
von Amsberg G, Steuber T, Bokemeyer C
Deut Arzteblatt. 2015;112(20):8-10.

Bosutinib
Amsberg G, Brümmendorf T
2014. Molekular zielgerichtete Therapie der chronischen myeloischen Leukämie (CML). Brümmendorf T, Koschmieder S (Hrsg.). 1. Aufl. Bremen-London-Boston: Uni-Med Verlag, 71-75.

Aktuelle Therapiekonzepte bei kastrationsresistenten Prostatakarzinom
Amsberg G, Strölin P, Bokemeyer C, Steuber T
DEUT MED WOCHENSCHR. 2014;139(41):2086-90.

Aaptamines from the marine sponge Aaptos sp. display anticancer activities in human cancer cell lines and modulate AP-1-, NF-κB-, and p53-dependent transcriptional activity in mouse JB6 Cl41 cells
Dyshlovoy S, Fedorov S, Shubina L, Kuzmich A, Bokemeyer C, Amsberg G, Honecker F
BIOMED RES INT . 2014;2014:469309.

Clinical management of epithelial ovarian cancer during pregnancy
Grimm D, Woelber L, Trillsch F, Keller-v. Amsberg G, Mahner S
EUR J CANCER. 2014;50(5):963-971.

Bosutinib: a novel second-generation tyrosine kinase inhibitor
Isfort S, Amsberg G, Schafhausen P, Koschmieder S, Brümmendorf T
Recent Results Cancer Res. 2014;201:81-97.

Quinone-carbohydrate nonglucoside conjugates as a new type of cytotoxic agents: synthesis and determination of in vitro activity
Pelageev D, Dyshlovoy S, Pokhilo N, Denisenko V, Borisova K, Amsberg G, Bokemeyer C, Fedorov S, Honecker F, Anufriev V
EUR J MED CHEM. 2014;77:139-44.

Moderne Systemtherapie des fortgeschrittenen Prostatakarzinoms
Steuber T, Stroeilin P, Amsberg G
Onkologie heute. 2014;(04):22-25.

Bosutinib in the management of chronic myelogenous leukemia
Amsberg G, Schafhausen P
Biologics. 2013;7:115-22.

Combination of a proteomics approach and reengineering of meso scale network models for prediction of mode-of-action for tyrosine kinase inhibitors
Balabanov S, Wilhelm T, Venz S, Amsberg G, Scharf C, Pospisil H, Balabanov M, Barett C, Bokemeyer C, Walther R, Brümmendorf T, Schuppert A
PLOS ONE. 2013;8(1):e53668.

Targeting aurora kinases with danusertib (PHA-739358) inhibits growth of liver metastases from gastroenteropancreatic neuroendocrine tumors in an orthotopic xenograft model.
Fraedrich K, Schrader J, Ittrich H, von Amsberg G, Gontarewicz A, Matzat V, Kromminga A, Pace A, Moll J, Bläker M, Lohse A, Hörsch D, Brümmendorf T, Benten D
CLIN CANCER RES. 2012;18(17):4621-4632.

Novel aspects of therapy with the dual Src and Abl kinase inhibitor bosutinib in chronic myeloid leukemia.
von Amsberg G, Brümmendorf T
EXPERT REV ANTICANC. 2012;12(9):1121-1127.

Abcg2 overexpression represents a novel mechanism for acquired resistance to the multi-kinase inhibitor Danusertib in BCR-ABL-positive cells in vitro.
Balabanov S, Gontarewicz A, von Amsberg G, Raddrizzani L, Balabanov M, Bosotti R, Moll J, Jost E, Barett C, Rohe I, Bokemeyer C, Holyoake T, Brümmendorf T
PLOS ONE. 2011;6(4):19164.

Multi tyrosine kinase inhibitor dasatinib as novel cause of severe pre-capillary pulmonary hypertension?
Hennigs J, von Amsberg G, Baumann H, Honecker F, Kluge S, Bokemeyer C, Brümmendorf T, Klose H
BMC PULM MED. 2011;11:30.

Bosutinib.
von Amsberg G, Schafhausen P, Brümmendorf T
Recent Results Cancer Res. 2010;184:119-127.

Simultaneous targeting of Aurora kinases and Bcr-Abl kinase by the small molecule inhibitor PHA-739358 is effective against imatinib-resistant BCR-ABL mutations including T315I.
Gontarewicz A, Balabanov S, von Amsberg G, Colombo R, Graziano A, Pesenti E, Benten D, Bokemeyer C, Fiedler W, Moll J, Brümmendorf T
BLOOD. 2008;111(8):4355-4364.

PHA-680626 exhibits anti-proliferative and pro-apoptotic activity on Imatinib-resistant chronic myeloid leukemia cell lines and primary CD34+ cells by inhibition of both Bcr-Abl tyrosine kinase and Aurora kinases.
Gontarewicz A, Balabanov S, von Amsberg G, Panse J, Schafhausen P, Bokemeyer C, Fiedler W, Moll J, Brümmendorf T
LEUKEMIA RES. 2008;32(12):1857-1865.

Esophageal squamous cell carcinoma presenting with extensive skin lesions: a case report.
Iwanski G, Block A, von Amsberg G, Münch J, Claus S, Fiedler W, Bokemeyer C
J Med Case Rep. 2008;2:115.

Letzte Aktualisierung aus dem FIS: 17.07.2017 - 00:02 Uhr