- Wissenschaftliche Mitarbeiterin
- Heisenberg-Professur für Virushepatitis
Fachgebiete
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Virushepatitis
Tätigkeitsschwerpunkte
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Forschung und Lehre
Auszeichnungen
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Preisträgerin einer „EMBO-Long-term Postdoc-Fellowship“ am Heinrich-Pette-Institut, Universität Hamburg (1999-2000).
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Stipendium Deutsche Krebshilfe (1998)
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Bewilligung für eine W3-Heisenberg-Professur (DFG) in Virushepatitis
Mitgliedschaften
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EASL
Publikationen
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1) Giersch K, et al.. Hepatitis Delta co-infection in humanized mice leads to pronounced induction of innate immune responses in comparison to HBV mono-infection. J Hepatol 2015 Mar 17; doi:10.1016/ j.jhep.2015.03.011. [Epub ahead of print]
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2) Oehler N, et al. Binding of hepatitis B virus to its cellular receptor alters the expression profile of genes of bile acid metabolism. Hepatology 2014 Nov;60(5):1483-93
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3) Allweiss L, et al. Immune cell responses are not required to induce substantial hepatitis B virus antigen decline during pegylated interferon-alpha administration. J Hepatol 2014 Mar 60(3):500-7.
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4) Giersch K, Helbig M, et al. Persistent hepatitis D virus mono-infection in humanized mice is efficiently converted by hepatitis B virus to a productive co-infection. J Hepatol 2014 Mar; 60(3):538-44.
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5) Volz T, Allweiss L et al. The entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized mice previously infected with hepatitis B virus. J.Hepatol. 2013; 58: 861-7.
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Belloni L, Allweiss L, et al. J Clin Invest. 2012 Feb 1;122(2):529-37
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7) Lütgehetmann M, Mancke LV,et al. Humanized chimeric uPA mouse model for the study of hepatitis B and D virus interactions and preclinical drug evaluation. Hepatology 2012 Mar;55(3):685-94.
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8) Lütgehetmann M, Bornscheuer T, et al. Hepatitis B Virus Limits Response of Human Hepatocytes to Interferon alpha in Chimeric Mice. Gastroenterology. 2011 Jun;140(7):2074-83.
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9) Lutgehetmann M, Volz T, et al. In vivo proliferation of hepadnavirus-infected hepatocytes induces loss of covalently closed circular DNA in mice Hepatology 2010 52(1):16-24
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10) Petersen J, Dandri M et al. Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein. Nat Biotechnol. 2008; 26:335-41
