ausgewählte Publikationen

Takahashi N, Oertner TG, Hegemann P, Larkum ME (2016) Active cortical dendrites modulate perception. Science 354: 1587-1590

Wietek J, Wiegert JS, Adeishvili N, Schneider F, Watanabe H, Tsunoda SP, Vogt A, Elstner M, Oertner TG, Hegemann P (2014) Conversion of Channelrhodopsin into a light-gated chloride channel. Science 344 (6182): 409-412.

Wiegert JS, Oertner TG (2013) Long-term depression eliminates poorly performing synapses. Proc Natl Acad Sci USA 110 (47): E4510-E4519.

Rose T, Schoenenberger P, Jezek K, Oertner TG (2013) Developmental refinement of vesicle cycling at Schaffer collateral synapses. Neuron 77(6):1109-21.

Huber D, Gutnisky DA, Peron S, O'Connor DH, Wiegert JS, Tian L, Oertner TG, Looger LL, Svoboda K (2012) Multiple dynamic representations in the motor cortex during sensorimotor learning. Nature 484(7395):473-8.

Berndt A, Schoenenberger P, Mattis J, Tye KM, Deisseroth K, Hegemann P, Oertner TG (2011) High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels. Proc Natl Acad Sci USA 108(18):7595-600.

Holbro N, Grunditz A, Wiegert JS, Oertner TG (2010) AMPA receptors gate spine Ca(2+) transients and spike-timing-dependent potentiation. Proc Natl Acad Sci USA 107(36):15975-80.

Holbro N, Grunditz A, Oertner TG (2009) Differential distribution of endoplasmic reticulum controls metabotropic signaling and plasticity at hippocampal synapses. Proc Natl Acad Sci USA 106(35):15055-60.

Grunditz A, Holbro N, Tian L, Zuo Y, Oertner TG (2008) Spine neck plasticity controls postsynaptic calcium signals through electrical compartmentalization. J Neurosci. 28(50):13457-66.

Zhang YP, Holbro N, Oertner TG (2008) Optical induction of plasticity at single synapses reveals input-specific accumulation of alphaCaMKII. Proc Natl Acad Sci USA 105(33):12039-44.

Zhang YP, Oertner TG (2007) Optical induction of synaptic plasticity using a light-sensitive channel. Nat Methods 4(2):139-41.

Vigot R, Barbieri S, Bräuner-Osborne H, Turecek R, Shigemoto R, Zhang YP, Luján R, Jacobson LH, Biermann B, Fritschy JM, Vacher CM, Müller M, Sansig G, Guetg N, Cryan JF, Kaupmann K, Gassmann M, Oertner TG, Bettler B (2006) Differential compartmentalization and distinct functions of GABAB receptor variants. Neuron 50(4):589-601.

Oertner TG, Sabatini BL, Nimchinsky EA, Svoboda K (2002) Facilitation at single synapses probed with optical quantal analysis. Nat Neurosci. 5(7):657-64.

Sabatini BL, Oertner TG, Svoboda K (2002) The life cycle of Ca(2+) ions in dendritic spines. Neuron 33(3):439-52.

  • Bender RA, Zhou L, Vierk R, Brandt N, Keller A, Gee CE, Schäfer MK, Rune GM (2016) Sex-dependent regulation of aromatase-mediated synaptic plasticity in the basolateral amygdala. J Neurosci. 1532-16.

    Takahasi N, Oertner TG, Hegemann P, Larkum ME (2016) Active cortical dendrites modulate perception. Science 354: 1587-1590.

    Wiegert JS, Oertner TG (2016) How (not) to silence long-range projections with light. (News & Views) Nature Neuroscience 19, 527-528.

    Gee CE, Oertner TG (2016) Neurobiology: Pull out the stops for plasticity. (News & Views) Nature 529(7585):164-5.

    Wiegert JS, Gee CE, Ohmert I, Oertner TG (2016) Stimulating neurons with light-gated channels. The Ion Channel Manual. Cold Spring Harbor Press (in press)

    Hernandez-Garzón E, Fernandez AM, Perez-Alvarez A, Genis L, Bascuñana P, Fernandez de la Rosa R, Delgado M, Angel Pozo M, Moreno E, McCormick PJ, Santi A, Trueba-Saiz A, Garcia-Caceres C, Tschöp MH, Araque A, Martin ED, Torres Aleman I.The insulin-like growth factor I receptor regulates glucose transport by astrocytes.Glia.2016 Jul 27. doi: 10.1002/glia.23035.

    Ana M. Fernandez, Edwin Hernandez-Garzón, P. Perez-Domper, Alberto PerezAlvarez, Sara Mederos, Takashi Matsui, Andrea Santi, Lucía García-Guerra,Julia Pose-Utrilla, Jens Fielitz, Eric N. Olson, Ruben Fernandez de la Rosa, Luis GarciaGarcia, Miguel Angel Pozo, Teresa Iglesias, Alfonso Araque, Hideaki Soya, GertrudisPerea, Eduardo D. Martin, Ignacio Torres Aleman, INSULIN REGULATES ASTROCYTIC GLUCOSE HANDLING THROUGH COOPERATION WITH INSULIN-LIKE GROWTH FACTOR I; Diabetes (In press)

  • Wietek J, Beltramo R, Scanziani M, Hegemann P, Oertner TG, Wiegert JS (2015) An improved chloride-conducting channelrhodopsin for light-induced inhibition of neuronal activity in vivo.Scientific Reports 5, 14807.

    Scheib U, Stehfest K, Gee CE, Körschen HG, Fudim R, Oertner TG, Hegemann P (2015) The rhodopsin-guanylyl cyclase of the aquatic fungus Blastocladiella emersonii enables fast optical control of cGMP signaling. Science Signaling 8(389):rs8.

    Wiegert JS, Oertner TG (2015) Neighborly synapses help each other out. Nature Neuroscience 18(3):326-7.

    Blumer C, Vivien C, Genoud C, Perez-Alvarez A, Wiegert JS, Vetter T, Oertner TG (2015) Automated analysis of spine dynamics on live CA1 pyramidal cells. Medical Image Analysis 19(1):87-97.

    Behnke D, Cotesta S, Hintermann S, Fendt M, Gee CE, Jacobson LH, Laue G, Meyer A, Wagner T, Badiger S, Chaudhari V, Chebrolu M, Pandit C, Hoyer D, Betschart C (2015) Discovery of 1H-pyrazolo[3,4-b]pyridines as potent dual orexin receptor antagonists (DORAs). Bioorg Med Chem Lett. 25(23):5555-60

    Kanatsou S, Fearey BC, Kuil LE, Lucassen PJ, Harris AP, Seckl JR, Krugers H, Joels M. (2015) Overexpression of Mineralocorticoid Receptors Partially Prevents Chronic Stress-Induced Reductions in Hippocampal Memory and Structural Plasticity. PLoS One.2015 Nov23;10(11):e0142012

  • Perez-Alvarez A, Navarrete M, Covelo A, Martin ED, Araque A (2014) Structural and functional plasticity of astrocyte processes and dendritic spine interactions. Journal of Neuroscience, 34(38):12738-44.

    Wietek J*, Wiegert JS*, Adeishvili N, Schneider F, Watanabe H, Tsunoda SP, Vogt A, Elstner M, Oertner TG, Hegemann P (2014) Conversion of Channelrhodopsin into a light-gated chloride channel. Science 344 (6182): 409-412.

    Oertner TG (2014) Active dendrites under parental supervision. Neuron 81(6):1217-19.

    Gee CE, Peterlik D, Neuhäuser C, Bouhelal R, Kaupmann K, Laue G, Uschold-Schmidt N, Feuerbach D, Zimmermann K, Ofner S, Cryan JF, van der Putten H, Fendt M, Vranesic I, Glatthar R, Flor PJ (2014) Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the venus flytrap domain (VFTD) inhibits amygdala plasticity, stress and anxiety-related behavior. Journal of Biological Chemistry 289(16):10975-87.

    Biermann B, Sokoll S, Klueva J, Missler M, Wiegert JS, Sibarita JB, Heine M (2014) Imaging of molecular surface dynamics in brain slices using single-particle tracking. Nature Communications 5: 3024.

  • Callander GE, Olorunda M, Monna D, Schuepbach E, Langenegger D, Betschart C, Hintermann S, Behnke D, Cotesta S, Fendt M, Laue G, Ofner S, Briard E, Gee CE, Jacobson LH, Hoyer D (2013) Kinetic properties of "dual" orexin receptor antagonists at OX1R and OX2R orexin receptors. Frontiers in Neuroscience 7: 230.

    Hoyer D, Dürst T, Fendt M, Jacobson LH, Betschart C, Hintermann S, Behnke D, Cotesta S, Laue G, Ofner S, Legangneux E, Gee CE (2013) Distinct effects of IPSU and suvorexant on mouse sleep architecture. Frontiers in Neuroscience 7: 235.

    Wiegert JS, Oertner TG (2013) Long-term depression triggers the selective elimination of weakly integrated synapses. Proc Natl Acad Sci USA 110 (47): E4510-E4519.

    Rose T, Schoenenberger P, Jezek K, Oertner TG (2013) Developmental refinement of vesicle cycling at Schaffer collateral synapses. Neuron 77(6):1109-21.

    Oertner TG, Helmchen F, de Lecea L, Beck H, Konnerth A, Kaupp B, Knöpfel T, Yawo H, Häusser M (2013) Optogenetic analysis of mammalian neural circuits. In Hegemann P & Sigrist S (Eds.), Optogenetics (pp. 109-126). Berlin: De Gryter. ISBN: 978-3-11-027072-3.

    Betschart C, Hintermann S, Behnke D, Cotesta S, Fendt M, Gee CE, Jacobson LH, Laue G, Ofner S, Chaudhari V, Badiger S, Pandit C, Wagner J, Hoyer D (2013) Identification of a Novel Series of Orexin Receptor Antagonists with a Distinct Effect on Sleep Architecture for the Treatment of Insomnia. J Med Chem. 56(19): 7590-607.

    Fendt M, Imobersteg S, Peterlik D, Chaperon F, Mattes C, Wittmann C, Olpe HR, Mosbacher J, Vranesic I, van der Putten H, McAllister KH, Flor PJ, Gee CE. Differential roles of mGlu(7) and mGlu(8) in amygdala-dependent behavior and physiology. Neuropharmacology 72: 215-23.

    Pérez-Alvarez A, Araque A, Martín ED (2013) Confocal microscopy for astrocyte in vivo imaging: Recycle and reuse in microscopy. Front Cell Neurosci. 7: 51.

    Pérez-Alvarez A, Araque A (2013) Astrocyte-Neuron Interaction At Tripartite Synapses. Curr Drug Targets 14(11): 1220-4.

  • Huber D, Gutnisky DA, Peron S, O'Connor DH, Wiegert JS, Tian L, Oertner TG, Looger LL, Svoboda K (2012) Multiple dynamic representations in the motor cortex during sensorimotor learning. Nature 484(7395):473-8.

    Hao J, Oertner TG (2012) Depolarization gates spine calcium transients and spike-timing-dependent potentiation. Curr Opin Neurobiol. 22(3):509-15.

    Bonapace L, Wyckoff J, Oertner TG, Van Rheenen J, Junt T, Bentires-Alj M (2012) If you don't look, you won't see: intravital multiphoton imaging of primary and metastatic breast cancer. J Mammary Gland Biol Neoplasia 17(2):125-9.

    Mang GM, Dürst T, Bürki H, Imobersteg S, Abramowski D, Schuepbach E, Hoyer D, Fendt M, Gee CE (2012) The dual orexin receptor antagonist almorexant induces sleep and decreases orexin-induced locomotion by blocking orexin 2 receptors. Sleep 35(12):1625-35.

    Chaperon F, Fendt M, Kelly PH, Lingenhoehl K, Mosbacher J, Olpe HR, Schmid P, Sturchler C, McAllister KH, van der Putten PH, Gee CE (2012) Gastrin-releasing peptide signaling plays a limited and subtle role in amygdala physiology and aversive memory. PLoS One 7(4):e34963.

    Luo W, Ruan D, Yan C, Yin S, Chen J (2012) Effects of chronic lead exposure on functions of nervous system in Chinese children and developmental rats. Neurotoxicology 33(4):862-71.

  • Berndt A, Schoenenberger P, Mattis J, K, Tye KM, Deisseroth K, Hegemann P, Oertner TG (2011) High-efficiency Channelrhodopsins for fast neuronal stimulation at low light levels. Proc Natl Acad Sci USA 108(18): 7595-7600.

    Wiegert JS, Oertner TG (2011) Shapeshifting for memory: Biochemical and electrical signaling in dendritic spines. e-Neuroforum 2011(2): 6-12.

    Stierl M, Stumpf P, Udwari D, Gueta R, Hagedorn R, Losi A, Gärtner W, Petereit L, Efetova M, Schwarzel M, Oertner TG, Nagel G, Hegemann P (2011) Light-modulation of cellular cAMP by a small bacterial photoactivated adenylyl cyclase, bPAC, of the soil bacteriumBeggiatoa. J Biol Chem. 286(2): 1181-8.

    Blumer C, Vivien C, Oertner TG, Vetter T (2011) Fluorescence image segmentation by using digitally reconstructed fluorescence images. Proceedings of the Sixth Workshop on Microscopic Image Analysis with Applications in Biology (MIAAB 2011), Heidelberg.

    Oertner TG (2011) The Lego-logic of optogenetics. Nat Methods 8(12):1011-3.

    Wiegert JS, Bading H (2011) Activity-dependent calcium signaling and ERK-MAP kinases in neurons: a link to structural plasticity of the nucleus and gene transcription regulation. Cell Calcium 49(5):296-305.