Prof. Dr. Dr.
Thomas Renné
  • Institutsdirektor
  • Facharzt für Laboratoriumsmedizin
Arbeitsbereich

Standort

O26 , 1. Etage, Raumnummer 195
Sprachen
Deutsch (Muttersprache)
Englisch

Fachgebiete

Tätigkeitsschwerpunkte

Publikationen

Zurück
  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • 2011
  • 2010
  • 2009
  • 2008
  • 2007
  • 2006
  • 2005
  • 2004
  • 2003
  • 2002
  • 2001
  • 2000
  • 1999
  • 1998
  • 1997
  • 1996
Vor

Neutrophils engage the kallikrein-kinin system to open up the endothelial barrier in acute inflammation
Kenne E, Rasmuson J, Renné T, Vieira M, Müller-Esterl W, Herwald H, Lindbom L
FASEB J. 2019;33(2):2599-2609.

Polyphosphate as a Target for Interference With Inflammation and Thrombosis
Mailer R, Hänel L, Allende M, Renné T
Frontiers in medicine. 2019;6:76.

Structural and Functional Analyses of the Shedding Protease ADAM17 in HoxB8-Immortalized Macrophages and Dendritic-like Cells
Cabron A, El Azzouzi K, Boss M, Arnold P, Schwarz J, Rosas M, Dobert J, Pavlenko E, Schumacher N, Renné T, Taylor P, Linder S, Rose-John S, Zunke F
J IMMUNOL. 2018;201(10):3106-3118.

A systems-approach reveals human nestin is an endothelial-enriched, angiogenesis-independent intermediate filament protein
Dusart P, Fagerberg L, Perisic L, Civelek M, Struck E, Hedin U, Uhlén M, Trégouët D, Renné T, Odeberg J, Butler L
SCI REP-UK. 2018;8(1):14668.

Human cytomegalovirus replication induces endothelial cell interleukin-11
Gustafsson K, Renné T, Söderberg-Naucler C, Butler L
CYTOKINE. 2018;111:563-566.

Circulating extracellular DNA is an independent predictor of mortality in elderly patients with venous thromboembolism
Jiménez-Alcázar M, Limacher A, Panda R, Méan M, Bitterling J, Peine S, Renné T, Beer J, Aujesky D, Lämmle B, Fuchs T
PLOS ONE. 2018;13(2):e0191150.

A Flow Cytometry-Based Assay for Procoagulant Platelet Polyphosphate
Labberton L, Long A, Gendler S, Snozek C, Stavrou E, Nickel K, Maas C, Blankenberg S, Hernandez J, Renné T
CYTOMETRY B CLIN CYTOM. 2018;94(2):369-373.

Coagulation factor XII in thrombosis and inflammation
Maas C, Renné T
BLOOD. 2018;131(17):1903-1909.

Atherothrombosis and Thromboembolism: Position Paper from the Second Maastricht Consensus Conference on Thrombosis
Spronk H, Padro T, Siland J, Prochaska J, Winters J, van der Wal A, Posthuma J, Lowe G, d'Alessandro E, Wenzel P, Coenen D, Reitsma P, Ruf W, van Gorp R, Koenen R, Vajen T, Alshaikh N, Wolberg A, Macrae F, Asquith N, Heemskerk J, Heinzmann A, Moorlag M, Mackman N, van der Meijden P, Meijers J, Heestermans M, Renné T, Dólleman S, Chayouâ W, Ariëns R, Baaten C, Nagy M, Kuliopulos A, Posma J, Harrison P, Vries M, Crijns H, Dudink E, Buller H, Henskens Y, Själander A, Zwaveling S, Erküner O, Eikelboom J, Gulpen A, Peeters F, Douxfils J, Olie R, Baglin T, Leader A, Schotten U, Scaf B, van Beusekom H, Mosnier L, van der Vorm L, Declerck P, Visser M, Dippel D, Strijbis V, Pertiwi K, Ten Cate-Hoek A, Ten Cate H
THROMB HAEMOSTASIS. 2018;118(2):229-250.

Laboratory diagnostics of murine blood for detection of mouse cytomegalovirus (MCMV)-induced hepatitis
Stahl F, Jung R, Jazbutyte V, Ostermann E, Tödter S, Brixel R, Kemmer A, Halle S, Rose-John S, Messerle M, Arck P, Brune W, Renné T
SCI REP-UK. 2018;8(1):14823.

Male offspring born to mildly ZIKV-infected mice are at risk of developing neurocognitive disorders in adulthood
Stanelle-Bertram S, Walendy-Gnirß K, Speiseder T, Thiele S, Asante I, Dreier C, Kouassi N, Preuß A, Pilnitz-Stolze G, Müller U, Thanisch S, Richter M, Scharrenberg R, Kraus V, Dörk R, Schau L, Herder V, Gerhauser I, Pfankuche V, Käufer C, Waltl I, Moraes T, Sellau J, Hoenow S, Schmidt-Chanasit J, Jansen S, Schattling B, Ittrich H, Bartsch U, Renné T, Bartenschlager R, Arck P, Cadar D, Friese M, Vapalahti O, Lotter H, Benites S, Rolling L, Gabriel M, Baumgärtner W, Morellini F, Hölter S, Amarie O, Fuchs H, Hrabe de Angelis M, Löscher W, Calderon de Anda F, Gabriel G
Nat Microbiol. 2018;3(10):1161-1174.

Factor XII and uPAR upregulate neutrophil functions to influence wound healing
Stavrou E, Fang C, Bane K, Long A, Naudin C, Kucukal E, Gandhi A, Brett-Morris A, Mumaw M, Izadmehr S, Merkulova A, Reynolds C, Alhalabi O, Nayak L, Yu W, Qu C, Meyerson H, Dubyak G, Gurkan U, Nieman M, Sen Gupta A, Renné T, Schmaier A
J CLIN INVEST. 2018;128(3):944-959.

Innate immune responses to toll-like receptor stimulation are altered during the course of pregnancy
Ziegler S, Feldmann C, Hagen S, Richert L, Barkhausen T, Goletzke J, Jazbutyte V, Martrus G, Salzberger W, Renné T, Hecher K, Diemert A, Arck P, Altfeld M
J REPROD IMMUNOL. 2018;128(SI):30-37.

Factor XII-Driven Inflammatory Reactions with Implications for Anaphylaxis
Bender L, Weidmann H, Rose-John S, Renné T, Long A
FRONT IMMUNOL. 2017;8:1115.

Novel targets for anticoagulants lacking bleeding risk
Bickmann J, Baglin T, Meijers J, Renné T
CURR OPIN HEMATOL. 2017;24(5):419-426.

Cross-talk between inflammation and coagulation
Bickmann J, Kiencke V, Long A, Renne T
2017. Hematology Education, 2017. 188 - 190.

MicroRNA-210 Enhances Fibrous Cap Stability in Advanced Atherosclerotic Lesions
Eken S, Jin H, Chernogubova E, Li Y, Simon N, Sun C, Korzunowicz G, Busch A, Bäcklund A, Österholm C, Razuvaev A, Renné T, Eckstein H, Pelisek J, Eriksson P, Gonzalez Diez M, Matic Perisic L, Schellinger I, Raaz U, Leeper N, Hansson G, Paulsson-Berne G, Hedin U, Maegdefessel L
CIRC RES. 2017;120(4):633-644.

Cleaved kininogen as a biomarker for bradykinin release in hereditary angioedema
Hofman Z, de Maat S, Suffritti C, Zanichelli A, van Doorn C, Sebastian S, Veszeli N, Csuka D, Renné T, Pasterkamp G, Cicardi M, Farkas H, Hack C, Maas C
J ALLERGY CLIN IMMUN. 2017;140(6):1700-1703.e8.

Host DNases prevent vascular occlusion by neutrophil extracellular traps
Jiménez-Alcázar M, Rangaswamy C, Panda R, Bitterling J, Simsek Y, Long A, Bilyy R, Krenn V, Renné C, Renné T, Kluge S, Panzer U, Mizuta R, Mannherz H, Kitamura D, Herrmann M, Napirei M, Fuchs T
SCIENCE. 2017;358(6367):1202-1206.

Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension
Kossmann S, Lagrange J, Jäckel S, Jurk K, Ehlken M, Schönfelder T, Weihert Y, Knorr M, Brandt M, Xia N, Li H, Daiber A, Oelze M, Reinhardt C, Lackner K, Gruber A, Monia B, Karbach S, Walter U, Ruggeri Z, Renné T, Ruf W, Münzel T, Wenzel P
SCI TRANSL MED. 2017;9(375):.

Thalidomide treatment prevents chronic graft rejection after aortic transplantation in rats
Miller K, Wang D, Hu X, Hua X, Deuse T, Neofytou E, Renne T, Velden J, Reichenspurner H, Schrepfer S, Bernstein D
TRANSPL INT. 2017;30(11):1181-1189.

Factor XII Contact Activation
Naudin C, Burillo E, Blankenberg S, Butler L, Renné T
SEMIN THROMB HEMOST. 2017;43(8):814-826.

Early diagnosis of acute myocardial infarction using high-sensitivity troponin I
Neumann J, Sörensen N, Ojeda F, Renné T, Schnabel R, Zeller T, Karakas M, Blankenberg S, Westermann D
PLOS ONE. 2017;12(3):e0174288.

Immediate Rule-Out of Acute Myocardial Infarction Using Electrocardiogram and Baseline High-Sensitivity Troponin I
Neumann J, Sörensen N, Ojeda F, Schwemer T, Lehmacher J, Gönner S, Jarsetz N, Keller T, Schaefer S, Renné T, Landmesser U, Clemmensen P, Makarova N, Schnabel R, Zeller T, Karakas M, Pickering J, Than M, Parsonage W, Greenslade J, Cullen L, Westermann D, Blankenberg S
CLIN CHEM. 2017;63(1):394-402.

Discrimination of patients with type 2 myocardial infarction
Neumann J, Sörensen N, Rübsamen N, Ojeda F, Renné T, Qaderi V, Teltrop E, Kramer S, Quantius L, Zeller T, Karakas M, Blankenberg S, Westermann D
EUR HEART J. 2017;38(47):3514-3520.

Factor XII as a Therapeutic Target in Thromboembolic and Inflammatory Diseases
Nickel K, Long A, Fuchs T, Butler L, Renné T
ARTERIOSCL THROM VAS. 2017;37(1):13-20.

Neutrophil Extracellular Traps Contain Selected Antigens of Anti-Neutrophil Cytoplasmic Antibodies
Panda R, Krieger T, Hopf L, Renné T, Haag F, Röber N, Conrad K, Csernok E, Fuchs T
FRONT IMMUNOL. 2017;8:439.

Neues vom Faktor XII
Renne T
Trillium Diagnostik. 2017;15(4):252-255.

Challenging the 99th percentile: A lower troponin cutoff leads to low mortality of chest pain patients
Sörensen N, Neumann J, Ojeda F, Schwemer T, Renné T, Schnabel R, Zeller T, Karakas M, Blankenberg S, Westermann D
INT J CARDIOL. 2017;232:289-293.

Polyphosphate nanoparticles on the platelet surface trigger contact system activation
Verhoef J, Barendrecht A, Nickel K, Dijkxhoorn K, Kenne E, Labberton L, McCarty O, Schiffelers R, Heijnen H, Hendrickx A, Schellekens H, Fens M, de Maat S, Renné T, Maas C
BLOOD. 2017;129(12):1707-1717.

The plasma contact system, a protease cascade at the nexus of inflammation, coagulation and immunity
Weidmann H, Heikaus L, Long A, Naudin C, Schlüter H, Renné T
BBA-MOL CELL RES. 2017;1864(11 Pt B):2118-2127.

Motor Performance Is not Enhanced by Daytime Naps in Older Adults
Backhaus W, Braass H, Renné T, Gerloff C, Hummel F
FRONT AGING NEUROSCI. 2016;8:125.

Daytime sleep has no effect on the time course of motor sequence and visuomotor adaptation learning
Backhaus W, Braaß H, Renné T, Krüger C, Gerloff C, Hummel F
NEUROBIOL LEARN MEM. 2016;131:147-54.

Analysis of Body-wide Unfractionated Tissue Data to Identify a Core Human Endothelial Transcriptome
Butler L, Hallström B, Fagerberg L, Pontén F, Uhlén M, Renné T, Odeberg J
Cell Syst. 2016;3(3):287-301.e3.

Plasmin is a natural trigger for bradykinin production in patients with hereditary angioedema with factor XII mutations
de Maat S, Björkqvist J, Suffritti C, Wiesenekker C, Nagtegaal W, Koekman A, van Dooremalen S, Pasterkamp G, de Groot P, Cicardi M, Renné T, Maas C
J ALLERGY CLIN IMMUN. 2016;138(5):1414-1423.e9.

The Selective JAK1/3-Inhibitor R507 Mitigates Obliterative Airway Disease Both With Systemic Administration and Aerosol Inhalation
Deuse T, Hua X, Stubbendorff M, Spin J, Neofytou E, Taylor V, Chen Y, Park G, Fink J, Renne T, Kiefmann M, Kiefmann R, Reichenspurner H, Robbins R, Schrepfer S
TRANSPLANTATION. 2016;100(5):1022-31.

A comparison of the effects of factor XII deficiency and prekallikrein deficiency on thrombus formation
Kokoye Y, Ivanov I, Cheng Q, Matafonov A, Dickeson S, Mason S, Sexton D, Renné T, McCrae K, Feener E, Gailani D
THROMB RES. 2016;140:118-124.

Neutralizing blood-borne polyphosphate in vivo provides safe thromboprotection
Labberton L, Kenne E, Long A, Nickel K, Di Gennaro A, Rigg R, Hernandez J, Butler L, Maas C, Stavrou E, Renné T
NAT COMMUN. 2016;7:12616.

Contact system revisited: an interface between inflammation, coagulation, and innate immunity
Long A, Kenne E, Jung R, Fuchs T, Renné T
J THROMB HAEMOST. 2016;14(3):427-37.

Urticaria as a Presenting Prodromal Manifestation of Attacks of Hereditary Angioedema
Martin L, Renné T, Drouet C
ACTA DERM-VENEREOL. 2016;96(4):574-5.

Diagnosis of Myocardial Infarction Using a High-Sensitivity Troponin I 1-Hour Algorithm
Neumann J, Sörensen N, Schwemer T, Ojeda F, Bourry R, Sciacca V, Schaefer S, Waldeyer C, Sinning C, Renné T, Than M, Parsonage W, Wildi K, Makarova N, Schnabel R, Landmesser U, Mueller C, Cullen L, Greenslade J, Zeller T, Blankenberg S, Karakas M, Westermann D
JAMA Cardiol. 2016;1(4):397-404.

The polyphosphate/factor XII pathway in cancer-associated thrombosis: novel perspectives for safe anticoagulation in patients with malignancies
Nickel K, Labberton L, Long A, Langer F, Fuchs T, Stavrou E, Butler L, Renné T
THROMB RES. 2016;141 Suppl 2:S4-7.

The Alzheimer's disease peptide Aβ promotes thrombin generation through activation of coagulation factor XII
Zamolodchikov D, Renné T, Strickland S
J THROMB HAEMOST. 2016;14(5):995-1007.

Defective glycosylation of coagulation factor XII underlies hereditary angioedema type III
Björkqvist J, de Maat S, Lewandrowski U, Di Gennaro A, Oschatz C, Schönig K, Nöthen M, Drouet C, Braley H, Nolte M, Sickmann A, Panousis C, Maas C, Renné T
J CLIN INVEST. 2015;125(8):3132-46.

Polyphosphates form antigenic complexes with platelet factor 4 (PF4) and enhance PF4-binding to bacteria
Brandt S, Krauel K, Jaax M, Renné T, Helm C, Hammerschmidt S, Delcea M, Greinacher A
THROMB HAEMOSTASIS. 2015;114(6):1189-98.

Direct infection of primary endothelial cells with human cytomegalovirus prevents angiogenesis and migration
Gustafsson R, Jeffery H, Yaiw K, Wilhelmi V, Kostopoulou O, Davoudi B, Rahbar A, Benard M, Renné T, Söderberg-Nauclér C, Butler L
J GEN VIROL. 2015;96(12):3598-3612.

Impaired DNase1-mediated degradation of neutrophil extracellular traps is associated with acute thrombotic microangiopathies
Jiménez-Alcázar M, Napirei M, Panda R, Köhler E, Kremer Hovinga J, Mannherz H, Peine S, Renné T, Lämmle B, Fuchs T
J THROMB HAEMOST. 2015;13(5):732-42.

Factor XII: a novel target for safe prevention of thrombosis and inflammation
Kenne E, Nickel K, Long A, Fuchs T, Stavrou E, Stahl F, Renné T
J INTERN MED. 2015;278(6):571-85.

New agents for thromboprotection. A role for factor XII and XIIa inhibition
Labberton L, Kenne E, Renné T
HAMOSTASEOLOGIE. 2015;35(4):338-50.

Thrombin generation test in children and adolescents with chronic liver disease
Magnusson M, Berndtsson M, Fischler B, Petrini P, Schulman S, Renne T, Granath A, Sten-Linder M, Németh A
THROMB RES. 2015;135(2):382-7.

The polyphosphate-factor XII pathway drives coagulation in prostate cancer-associated thrombosis
Nickel K, Ronquist G, Langer F, Labberton L, Fuchs T, Bokemeyer C, Sauter G, Graefen M, Mackman N, Stavrou E, Ronquist G, Renné T
BLOOD. 2015;126(11):1379-89.

The vascular side of plasma kallikrein
Renné T
BLOOD. 2015;125(4):589-90.

Plasma contact system activation drives anaphylaxis in severe mast cell-mediated allergic reactions
Sala-Cunill A, Björkqvist J, Senter R, Guilarte M, Cardona V, Labrador M, Nickel K, Butler L, Luengo O, Kumar P, Labberton L, Long A, Di Gennaro A, Kenne E, Jämsä A, Krieger T, Schlüter H, Fuchs T, Flohr S, Hassiepen U, Cumin F, McCrae K, Maas C, Stavrou E, Renné T
J ALLERGY CLIN IMMUN. 2015;135(4):1031-1043.e6.

Thrombin generation in a patient with an acquired high-titre factor V inhibitor
Schmidt D, Steinhagen F, Schnabel C, Spath B, Holstein K, Fiedler W, Bokemeyer C, Renné T, Langer F
BLOOD COAGUL FIBRIN. 2015;26(1):81-87.

First report of a FXII gene mutation in a Brazilian family with hereditary angioedema with normal C1 inhibitor
Stieber C, Grumach A, Cordeiro E, Constantino-Silva R, Barth S, Hoffmann P, Renné T, Nöthen M, Cichon S
BRIT J DERMATOL. 2015;173(4):1102-1104.

The factor XIIa blocking antibody 3F7: a safe anticoagulant with anti-inflammatory activities
Worm M, Köhler E, Panda R, Long A, Butler L, Stavrou E, Nickel K, Fuchs T, Renné T
J TRANSL MED. 2015;3(17):247.

Activation of the factor XII-driven contact system in Alzheimer's disease patient and mouse model plasma
Zamolodchikov D, Chen Z, Conti B, Renné T, Strickland S
P NATL ACAD SCI USA. 2015;112(13):4068-73.

PKA-regulated VASP phosphorylation promotes extrusion of transformed cells from the epithelium
Anton K, Sinclair J, Ohoka A, Kajita M, Ishikawa S, Benz P, Renne T, Balda M, Jorgensen C, Matter K, Fujita Y
J CELL SCI. 2014;127(16):3425-33.

In vivo activation and functions of the protease factor XII
Björkqvist J, Nickel K, Stavrou E, Renne T
THROMB HAEMOSTASIS. 2014;112(5):868-875.

Characterisation of the conformational changes in platelet factor 4 induced by polyanions: towards in vitro prediction of antigenicity
Brandt S, Krauel K, Gottschalk K, Renné T, Helm C, Greinacher A, Block S
THROMB HAEMOSTASIS. 2014;112(1):.

Classification, diagnosis, and approach to treatment for angioedema: consensus report from the Hereditary Angioedema International Working Group
Cicardi M, Aberer W, Banerji A, Bas M, Bernstein J, Bork K, Caballero T, Farkas H, Grumach A, Kaplan A, Riedl M, Triggiani M, Zanichelli A, Zuraw B
ALLERGY. 2014;69(5):602-16.

Factor XII - a drug target for safe interference with thrombosis and inflammation
Kenne E, Renné T
Drug discovery today. 2014;19(9):1459-64.

A case of severe Ebola virus infection complicated by gram-negative septicemia
Kreuels B, Wichmann D, Emmerich P, Schmidt-Chanasit J, Heer G, Kluge S, Sow A, Renné T, Günther S, Lohse A, Addo M, Schmiedel S
NEW ENGL J MED. 2014;371(25):2394-401.

Factor XII Regulates the Pathological Process of Thrombus Formation on Ruptured Plaques
Kuijpers M, van der Meijden P, Feijge M, Mattheij N, May F, Govers-Riemslag J, Meijers J, Heemskerk J, Renné T, Cosemans J
ARTERIOSCL THROM VAS. 2014;34(8):1674-80.

A factor XIIa inhibitory antibody provides thromboprotection in extracorporeal circulation without increasing bleeding risk
Larsson M, Rayzman V, Nolte M, Nickel K, Björkqvist J, Jämsä A, Hardy M, Fries M, Schmidbauer S, Hedenqvist P, Broomé M, Pragst I, Dickneite G, Wilson M, Nash A, Panousis C, Renné T
SCI TRANSL MED. 2014;6(222):222ra17.

Bradykinin in health and disease: proceedings of the Bradykinin Symposium 2012, Berlin 23-24 August 2012
Magerl M, Bader M, Gompel A, Joseph K, Kaplan A, Kojda G, Renné T, Wirth M, Maurer M, Church M
INFLAMM RES. 2014;63(3):173-8.

Factor XII inhibition reduces thrombus formation in a primate thrombosis model
Matafonov A, Leung P, Gailani A, Grach S, Puy C, Cheng Q, Sun M, McCarty O, Tucker E, Kataoka H, Renné T, Morrissey J, Gruber A, Gailani D
BLOOD. 2014;123(11):1739-46.

Mena/VASP and αII-Spectrin complexes regulate cytoplasmic actin networks in cardiomyocytes and protect from conduction abnormalities and dilated cardiomyopathy
Benz P, Merkel C, Offner K, Abeßer M, Ullrich M, Fischer T, Bayer B, Wagner H, Gambaryan S, Ursitti J, Adham I, Linke W, Feller S, Fleming I, Renné T, Frantz S, Unger A, Schuh K
CELL COMMUN SIGNAL. 2013;11:56.

Plasma kallikrein the bradykinin-producing enzyme
Björkqvist J, Jämsä A, Renné T
THROMB HAEMOSTASIS. 2013;110(3):399-407.

Zinc-dependent contact system activation induces vascular leakage and hypotension in rodents
Björkqvist J, Lecher B, Maas C, Renné T
BIOL CHEM. 2013;394(9):1195-204.

Hereditary angioedema: a bradykinin-mediated swelling disorder
Björkqvist J, Sala-Cunill A, Renné T
THROMB HAEMOSTASIS. 2013;109(3):368-74.

Fetuin-B, a liver-derived plasma protein is essential for fertilization
Dietzel E, Wessling J, Floehr J, Schäfer C, Ensslen S, Denecke B, Rösing B, Neulen J, Veitinger T, Spehr M, Tropartz T, Tolba R, Renné T, Egert A, Schorle H, Gottenbusch Y, Hildebrand A, Yiallouros I, Stöcker W, Weiskirchen R, Jahnen-Dechent W
DEV CELL. 2013;25(1):106-12.

Time-dependent degradation and tissue factor addition mask the ability of platelet polyphosphates in activating factor XII-mediated coagulation
Nickel K, Spronk H, Mutch N, Renné T
BLOOD. 2013;122(23):3847-9.

Increased expression of heparanase in symptomatic carotid atherosclerosis.
Osterholm C, Folkersen L, Lengquist M, Pontén F, Renné T, Li J, Hedin U
ATHEROSCLEROSIS. 2013;226(1):67-73.

Magnetic resonance T1 relaxation time of venous thrombus is determined by iron processing and predicts susceptibility to lysis
Saha P, Andia M, Modarai B, Blume U, Humphries J, Patel A, Phinikaridou A, Evans C, Mattock K, Grover S, Ahmad A, Lyons O, Attia R, Renné T, Premaratne S, Wiethoff A, Botnar R, Schaeffter T, Waltham M, Smith A
CIRCULATION. 2013;128(7):729-36.

The kallikreins: old proteases with new clinical potentials
Schmitt M, Renné T, Scorilas A
THROMB HAEMOSTASIS. 2013;110(3):396-8.

Emerging functions of the plasma contact system for hereditary angioedema.
Björkqvist J, Müller F, Renné T
journal of angioedema. 2012;(J. Angioedema ):56-63.

Tissue factor-positive neutrophils bind to injured endothelial wall and initiate thrombus formation.
Darbousset R, Thomas G, Mezouar S, Frère C, Bonier R, Mackman N, Renné T, Dignat-George F, Dubois C, Panicot-Dubois L
BLOOD. 2012;120(10):2133-2143.

Regulatory mechanisms of the plasma contact system.
Maas C, Renné T
THROMB RES. 2012;129 Suppl 2:73-76.

Crosstalk of the plasma contact system with bacteria.
Nickel K, Renné T
THROMB RES. 2012;130 Suppl 1:78-83.

The procoagulant and proinflammatory plasma contact system.
Renné T
SEMIN IMMUNOPATHOL. 2012;34(1):31-41.

The plasma contact system
Renné T, Colman R, Mader V, Clowes A, George J, Goldhaber S
2012. Thrombosis and Hemostasis. LIPPINCOTT WILLIAMS & WILKINS, .

Plasma kallikrein: novel functions for an old protease.
Renné T, Gruber A
THROMB HAEMOSTASIS. 2012;107(6):1012-1013.

In vivo roles of factor XII.
Renné T, Schmaier A, Nickel K, Blombäck M, Maas C
BLOOD. 2012;120(22):4296-4303.

Platelet- and erythrocyte-derived microparticles trigger thrombin generation via factor XIIa.
Van Der Meijden P, Van Schilfgaarde M, Van Oerle R, Renné T, Ten Cate H, Spronk H
J THROMB HAEMOST. 2012;10(7):1355-1362.

Factor XI and the Plasma Contact System
Gailani D, Renné T
2011. Metabolic & Molecular Bases of Inherited Disease. 9. Aufl. .

Decreased active von Willebrand factor level owing to shear stress in aortic stenosis patients.
Hollestelle M, Loots C, Squizzato A, Renné T, Bouma B, de Groot P, Lenting P, Meijers J, Gerdes V
J THROMB HAEMOST. 2011;9(5):953-958.

Factor XII activation is essential to sustain the procoagulant effects of particulate matter.
Kilinç E, Van Oerle R, Borissoff J, Oschatz C, Gerlofs-Nijland M, Janssen N, Cassee F, Sandström T, Renné T, Ten Cate H, Spronk H
J THROMB HAEMOST. 2011;9(7):1359-1367.

Impaired melanoma growth in VASP deficient mice.
Kim Y, Renné C, Seifert S, Schuh K, Renné T
FEBS LETT. 2011;585(15):2533-2536.

Differential effects of heart rate reduction with ivabradine in two models of endothelial dysfunction and oxidative stress.
Kröller-Schön S, Schulz E, Wenzel P, Kleschyov A, Hortmann M, Torzewski M, Oelze M, Renné T, Daiber A, Münzel T
BASIC RES CARDIOL. 2011;106(6):1147-1158.

The plasma contact system 2.0.
Maas C, Oschatz C, Renné T
SEMIN THROMB HEMOST. 2011;37(4):375-381.

Factor XI and XII as antithrombotic targets.
Müller F, Gailani D, Renné T
CURR OPIN HEMATOL. 2011;18(5):349-355.

Targeting FXI and FXII for anticoagulation
Müller F, Gailani D, Renné T
CURR OPIN HEMATOL. 2011;(18):349-355.

Platelet polyphosphates: the nexus of primary and secondary hemostasis.
Müller F, Renné T
SCAND J CLIN LAB INV. 2011;71(2):82-86.

Mast cells increase vascular permeability by heparin-initiated bradykinin formation in vivo.
Oschatz C, Maas C, Lecher B, Jansen T, Björkqvist J, Tradler T, Sedlmeier R, Burfeind P, Cichon S, Hammerschmidt S, Müller-Esterl W, Wuillemin W, Nilsson G, Renné T
IMMUNITY. 2011;34(2):258-268.

The Kallikrein-kinin system and thrombosis
Renné T
2011. Kinins. Bader M (Hrsg.). 1. Aufl. Walter De Gruyter GmbH & Co. KG, Berlin/Boston, 203-210.

Identification of SPRED2 (sprouty-related protein with EVH1 domain 2) as a negative regulator of the hypothalamic-pituitary-adrenal axis.
Ullrich M, Bundschu K, Benz P, Abesser M, Freudinger R, Fischer T, Ullrich J, Renné T, Walter U, Schuh K
J BIOL CHEM. 2011;286(11):9477-9488.

A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo.
Cheng Q, Tucker E, Pine M, Sisler I, Matafonov A, Sun M, White-Adams T, Smith S, Hanson S, McCarty O, Renné T, Gruber A, Gailani D
BLOOD. 2010;116(19):3981-3989.

VASP phosphorylation at serine239 regulates the effects of NO on smooth muscle cell invasion and contraction of collagen.
Defawe O, Kim S, Chen L, Huang D, Kenagy R, Renné T, Walter U, Daum G, Clowes A
J CELL PHYSIOL. 2010;222(1):230-237.

Herpes simplex virus type 1 entry into epithelial MDCKII cells: role of VASP activities.
Jaeger V, Hoppe S, Petermann P, Liebig T, Jansen M, Renné T, Knebel-Mörsdorf D
J GEN VIROL. 2010;91(Pt 9):2152-2157.

Enhanced cortical reperfusion protects coagulation factor XII-deficient mice from ischemic stroke as revealed by high-field MRI.
Pham M, Kleinschnitz C, Helluy X, Bartsch A, Austinat M, Behr V, Renné T, Nieswandt B, Stoll G, Bendszus M
NEUROIMAGE. 2010;49(4):2907-2914.

Inhibition of bradykinin receptor B1 protects mice from focal brain injury by reducing blood-brain barrier leakage and inflammation.
Raslan F, Schwarz T, Meuth S, Austinat M, Bader M, Renné T, Roosen K, Stoll G, Sirén A, Kleinschnitz C
J CEREBR BLOOD F MET. 2010;30(8):1477-1486.

Safe(r) anticoagulation.
Renné T
BLOOD. 2010;116(22):4390-4391.

Blockade of bradykinin receptor B1 but not bradykinin receptor B2 provides protection from cerebral infarction and brain edema
Austinat M, Braeuninger S, Pesquero J, Brede M, Bader M, Stoll G, Renné T, Kleinschnitz C
STROKE. 2009;40(1):285-93.

Differential VASP phosphorylation controls remodeling of the actin cytoskeleton
Benz P, Blume C, Seifert S, Wilhelm S, Waschke J, Schuh K, Gertler F, Münzel T, Renné T
J CELL SCI. 2009;122(Pt 21):3954-65.

The ADMA/DDAH pathway regulates VEGF-mediated angiogenesis
Fiedler L, Bachetti T, Leiper J, Zachary I, Chen L, Renné T, Wojciak-Stothard B
ARTERIOSCL THROM VAS. 2009;29(12):2117-24.

Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo
Müller F, Mutch N, Schenk W, Smith S, Esterl L, Spronk H, Schmidbauer S, Gahl W, Morrissey J, Renné T
CELL. 2009;139(6):1143-56.

Factor XI deficiency in animal models
Renné T, Oschatz C, Seifert S, Müller F, Antovic J, Karlman M, Benz P
J THROMB HAEMOST. 2009;7 Suppl 1:79-83.

Dual role of collagen in factor XII-dependent thrombus formation
van der Meijden P, Munnix I, Auger J, Govers-Riemslag J, Cosemans J, Kuijpers M, Spronk H, Watson S, Renné T, Heemskerk J
BLOOD. 2009;114(4):881-90.

Modulation of Rac1 activity by ADMA/DDAH regulates pulmonary endothelial barrier function
Wojciak-Stothard B, Torondel B, Zhao L, Renné T, Leiper J
MOL BIOL CELL. 2009;20(1):33-42.

Cytoskeleton assembly at endothelial cell-cell contacts is regulated by alphaII-spectrin-VASP complexes
Benz P, Blume C, Moebius J, Oschatz C, Schuh K, Sickmann A, Walter U, Feller S, Renné T
J CELL BIOL. 2008;180(1):205-19.

Prostaglandin-induced VASP phosphorylation controls alpha II-spectrin breakdown in apoptotic cells
Benz P, Feller S, Sickmann A, Walter U, Renné T
International immunopharmacology. 2008;8(2):319-24.

Transmission of oxLDL-derived lipid peroxide radicals into membranes of vascular cells is the main inducer of oxLDL-mediated oxidative stress
Hansen-Hagge T, Baumeister E, Bauer T, Schmiedeke D, Renné T, Wanner C, Galle J
ATHEROSCLEROSIS. 2008;197(2):602-11.

Deficiency of bradykinin receptor B2 is not detrimental in experimental stroke
Kleinschnitz C, Austinat M, Bader M, Renné T, Stoll G
HYPERTENSION. 2008;51(5):e41; author reply e42-3.

Blocking of platelets or intrinsic coagulation pathway-driven thrombosis does not prevent cerebral infarctions induced by photothrombosis
Kleinschnitz C, Braeuninger S, Pham M, Austinat M, Nölte I, Renné T, Nieswandt B, Bendszus M, Stoll G
STROKE. 2008;39(4):1262-8.

Differential phosphoproteome profiling reveals a functional role for VASP in Helicobacter pylori-induced cytoskeleton turnover in gastric epithelial cells
Knauer O, Binai N, Carra G, Beckhaus T, Hanschmann K, Renné T, Backert S, Karas M, Wessler S
CELL MICROBIOL. 2008;10(11):2285-96.

Novel roles for factor XII-driven plasma contact activation system
Müller F, Renné T
CURR OPIN HEMATOL. 2008;15(5):516-21.

Insulin inhibition of platelet-endothelial interaction is mediated by insulin effects on endothelial cells without direct effects on platelets
Rauchfuss S, Geiger J, Walter U, Renne T, Gambaryan S
J THROMB HAEMOST. 2008;6(5):856-64.

Role of vasodilator-stimulated phosphoprotein in cGMP-mediated protection of human pulmonary artery endothelial barrier function
Rentsendorj O, Mirzapoiazova T, Adyshev D, Servinsky L, Renné T, Verin A, Pearse D
AM J PHYSIOL-LUNG C. 2008;294(4):L686-97.

Improvement of vascular function by acute and chronic treatment with the PDE-5 inhibitor sildenafil in experimental diabetes mellitus
Schäfer A, Fraccarollo D, Pförtsch S, Flierl U, Vogt C, Pfrang J, Kobsar A, Renné T, Eigenthaler M, Ertl G, Bauersachs J
BRIT J PHARMACOL. 2008;153(5):886-93.

The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction
Varga-Szabo D, Braun A, Kleinschnitz C, Bender M, Pleines I, Pham M, Renné T, Stoll G, Nieswandt B
J EXP MED. 2008;205(7):1583-91.

AMP-activated protein kinase impairs endothelial actin cytoskeleton assembly by phosphorylating vasodilator-stimulated phosphoprotein
Blume C, Benz P, Walter U, Ha J, Kemp B, Renné T
J BIOL CHEM. 2007;282(7):4601-12.

Conditional neuronal nitric oxide synthase overexpression impairs myocardial contractility
Burkard N, Rokita A, Kaufmann S, Hallhuber M, Wu R, Hu K, Hofmann U, Bonz A, Frantz S, Cartwright E, Neyses L, Maier L, Maier S, Renné T, Schuh K, Ritter O
CIRC RES. 2007;100(3):e32-44.

Ena/VASP proteins mediate repulsion from ephrin ligands
Evans I, Renne T, Gertler F, Nobes C
J CELL SCI. 2007;120(Pt 2):289-98.

Intrinsic pathway of coagulation and arterial thrombosis
Gailani D, Renné T
ARTERIOSCL THROM VAS. 2007;27(12):2507-13.

The intrinsic pathway of coagulation a target for treating thromboembolic disease?
Gailani D, Renné T
J THROMB HAEMOST. 2007;5(6):1106-12.

Modulation of lamellipodial structure and dynamics by NO-dependent phosphorylation of VASP Ser239
Lindsay S, Ramsey S, Aitchison M, Renné T, Evans T
J CELL SCI. 2007;120(Pt 17):3011-21.

Role of Factor XII in hemostasis and thrombosis: clinical implications
Renné T, Gailani D
Expert review of cardiovascular therapy. 2007;5(4):733-41.

Increased activity of coagulation factor XII (Hageman factor) causes hereditary angioedema type III
Cichon S, Martin L, Hennies H, Müller F, Van Driessche K, Karpushova A, Stevens W, Colombo R, Renné T, Drouet C, Bork K, Nöthen M
AM J HUM GENET. 2006;79(6):1098-104.

Platelets promote coagulation factor XII-mediated proteolytic cascade systems in plasma
Johne J, Blume C, Benz P, Pozgajová M, Ullrich M, Schuh K, Nieswandt B, Walter U, Renné T
BIOL CHEM. 2006;387(2):173-8.

Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis
Kleinschnitz C, Stoll G, Bendszus M, Schuh K, Pauer H, Burfeind P, Renné C, Gailani D, Nieswandt B, Renné T
J EXP MED. 2006;203(3):513-8.

The intrinsic pathway of coagulation is essential for thrombus stability in mice
Renné T, Nieswandt B, Gailani D
BLOOD CELL MOL DIS. 2006;36(2):148-51.

Gene disruption of Spred-2 causes dwarfism
Bundschu K, Knobeloch K, Ullrich M, Schinke T, Amling M, Engelhardt C, Renné T, Walter U, Schuh K
J BIOL CHEM. 2005;280(31):28572-80.

Vasodilator-stimulated phosphoprotein-deficient mice demonstrate increased platelet activation but improved renal endothelial preservation and regeneration in passive nephrotoxic nephritis
Hohenstein B, Kasperek L, Kobelt D, Daniel C, Gambaryan S, Renné T, Walter U, Amann K, Hugo C
J AM SOC NEPHROL. 2005;16(4):986-96.

Defective thrombus formation in mice lacking coagulation factor XII
Renné T, Pozgajová M, Grüner S, Schuh K, Pauer H, Burfeind P, Gailani D, Nieswandt B
J EXP MED. 2005;202(2):271-81.

Local bradykinin formation is controlled by glycosaminoglycans
Renné T, Schuh K, Müller-Esterl W
J IMMUNOL. 2005;175(5):3377-85.

Expression and subcellular localization of Spred proteins in mouse and human tissues
Engelhardt C, Bundschu K, Messerschmitt M, Renné T, Walter U, Reinhard M, Schuh K
Histochem Cell Biol. 2004;122(6):527-38.

Targeted deletion of murine coagulation factor XII gene-a model for contact phase activation in vivo
Pauer H, Renné T, Hemmerlein B, Legler T, Fritzlar S, Adham I, Müller-Esterl W, Emons G, Sancken U, Engel W, Burfeind P
THROMB HAEMOSTASIS. 2004;92(3):503-8.

Structural basis of calcification inhibition by alpha 2-HS glycoprotein/fetuin-A. Formation of colloidal calciprotein particles
Heiss A, DuChesne A, Denecke B, Grötzinger J, Yamamoto K, Renné T, Jahnen-Dechent W
J BIOL CHEM. 2003;278(15):13333-41.

Characterization of the H-kininogen-binding site on factor XI: a comparison of factor XI and plasma prekallikrein
Renné T, Gailani D, Meijers J, Müller-Esterl W
J BIOL CHEM. 2002;277(7):4892-9.

Fine mapping of the H-kininogen binding site in plasma prekallikrein apple domain 2
Renné T, Sugiyama A, Gailani D, Jahnen-Dechent W, Walter U, Müller-Esterl W
International immunopharmacology. 2002;2(13-14):1867-73.

Cell surface-associated chondroitin sulfate proteoglycans bind contact phase factor H-kininogen
Renné T, Müller-Esterl W
FEBS LETT. 2001;500(1-2):36-40.

High molecular weight kininogen utilizes heparan sulfate proteoglycans for accumulation on endothelial cells
Renné T, Dedio J, David G, Müller-Esterl W
J BIOL CHEM. 2000;275(43):33688-96.

Subcellular targeting of multiligand-binding protein gC1qR
Dedio J, Renné T, Weisser M, Müller-Esterl W
Immunopharmacology. 1999;45(1-3):1-5.

Mapping of the discontinuous H-kininogen binding site of plasma prekallikrein. Evidence for a critical role of apple domain-2
Renné T, Dedio J, Meijers J, Chung D, Müller-Esterl W
J BIOL CHEM. 1999;274(36):25777-84.

Molecular co-operation between protein PAM and streptokinase for plasmin acquisition by Streptococcus pyogenes
Ringdahl U, Svensson M, Wistedt A, Renné T, Kellner R, Müller-Esterl W, Sjöbring U
J BIOL CHEM. 1998;273(11):6424-30.

Absorption of kininogen from human plasma by Streptococcus pyogenes is followed by the release of bradykinin
Ben Nasr A, Herwald H, Sjöbring U, Renné T, Müller-Esterl W, Björck L
BIOCHEM J. 1997;326 ( Pt 3):657-60.

Mapping of the discontinuous kininogen binding site of prekallikrein. A distal binding segment is located in the heavy chain domain A4
Herwald H, Renné T, Meijers J, Chung D, Page J, Colman R, Müller-Esterl W
J BIOL CHEM. 1996;271(22):13061-7.

Letzte Aktualisierung aus dem FIS: 18.08.2019 - 00:35 Uhr