2nd funding period of Research Unit FOR2625 approved

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End of September the German Research Foundation approved the 2nd funding period of the Research Unit FOR 2625 "Mechanisms of Lysosomal Homeostasis" with a funding volume of 3.98 million euro.

The Research Unit was established in October 2017 and consists of eleven German and one Dutch research groups. It aims at elucidating the biogenesis, functions and turnover of lysosomes as a whole, and protein-protein and lipid-protein interactions at the cytosolic surface of lysosomes. Analysing the molecular mechanisms that maintain lysosomal homeostasis will contribute to understand the cause of lysosomal disorders, thereby enabling the development of long-term preclinical therapeutic strategies.

Participating Researchers of the second funding period: Thomas Braulke (Hamburg), Anja Bremm (Frankfurt/Main), Markus Damme (Kiel), Ivan Dikic (Frankfurt/Main), Volker Haucke (Berlin), Christian Hübner (Jena), Thomas Jentsch (Berlin), Judith Klumperman (Utrecht, NL), Tassula Proikas-Cezanne (Tübingen), Paul Saftig (Kiel), Tobias Stauber (Hamburg), Dominic Winter (Bonn)


Invitation to FOR2625 Symposium LYSOSOMES & AUTOPHAGY

NEW DATE: April 29 - 30, 2021

Max Delbrück Communications Center, Berlin-Buch

Due to the coronavirus outbreak the FOR2625 symposium is postponed from June 2020 to April 2021!

The members of the Research Unit FOR2625 "Mechanisms of Lysosomal Homeostasis" invite scientists from all over the world to join our International FOR2625 Symposium on LYSOSOMES & AUTOPHAGY.

Outstanding scientists have confirmed their participation in our two-day program and will present their newest findings on the molecular machinery of the endo-lysosomal system and autophagy. The symposium offers a great opportunity for young and more advanced researchers to meet internationally renowned experts and discuss their projects during scientific sessions as well as during social events.

Registration will open on November 16, 2020 und is limited to 160 participants.

For further information please visit www.lysosomes2021.de

link to FOR2625 symposium's website

download save the date-poster (PDF)

link to website of Research Unit FOR2625

Invitation to FOR2625 Seminar with Margaret S. Robinson (CIMR, UK)

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Margaret S. Robinson
- Cambridge Institute for Medical Research (UK)
AP-4 and AP-5: the mystery adaptors and their role in autophagy and lysosomal homeostasis

Due to the corona virus outbreak this seminar -originally scheduled for March 2020- is postponed. The new date will be announced on this website as soon as possible.

University Hospital Jena
Forschungszentrum Lobeda
Building F2 (FUI), seminar room 10
Am Klinikum 1, 07743 Jena

link FOR2625 seminars


Lena Westermann wins two presentation prizes

Our medical student and doctoral candidate Lena Westermann was honored at two conferences for her presentations. In March her poster presentation entitled Targeting of pro-osteoclastogenic interleukin-6 in mucolipidosis type II as a potential corrective approach was awarded with the Dr. Ursula Wachtel Poster prize at the "Jahrestagung der Arbeitsgemeinschaft für Pädiatrische Stoffwechselerkrankungen (APS)" in Fulda. In addition Lena won the Free Communication Award at the 50. EMG (European Metabolic Group) Conference, that took place in June in Hamburg.

Project-website "Mucolipidosis type II and III" (Prof. Thomas Braulke/ Dr. Sandra Pohl)

Website APS

Research for Rare: Study by Schulz et al. highlighted as Paper of the Month

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The recently pushlished study by Angela Schulz and colleagues "Study of intraventricular Cerliponase Alfa for CLN2 disease" that was conducted within the frame of our research consortium NCL2TREAT is highlighted as Paper of the Month on the website of the research network "Research for Rare -German networks on rare diseases". The rare lysosomal storage disorder CLN2 is a late-infantile form of neuronal ceroid lipofuscinoses and is characterized by epilepsy, loss of speech, vision and motoric skills, and by early death. The study by Schulz et al. was published in the New England Journal of Medicine and could show that an enzyme replacement therapy using the recombinant enzyme tripeptidyl peptidase 1 (cerliponase alfa) could positively influence the course of the disease and even stop the loss of motor and language function in a subset of patients.

Research for Rare Paper of the Month

website NCL2TREAT

NCL2TREAT portrayed in Research for Rare newsletter

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The latest issue of the Research for Rare newsletter includes a potrait feature on our research network NCL2TREAT. (Article in German only.)

Download R4R Newsletter 02/2018


Giorgia Di Lorenzo awarded at 21st ESGLD Meeting in Lyon

Our PhD student Giorgia Di Lorenzo received the Young Scientist Award at the 21. meeting of the "European Study Group on Lysosomal Disorders" (September 14th - 17th 2017, Lyon/France). She was awarded in the categorie "best oral presentation" for her talk entitled Role of the gamma-subunit of GlcNAc-1-phosphotransferase in the pathogenesis of mucolipidosis type III.

As part of her PhD project Giorgia Di Lorenzo investigates the molecular mechanisms that lead to the lysosomal storage disorder mucolipidosis type III, an inherited metabolic disease that is caused by defects in the GlcNAc-1-phosphotransferase complex. This enzyme complex plays a key role in generating the mannose 6-phosphate recognition marker on lysosomal enzymes which is essential for their efficient transport to lysosomes. In mucolipidosis type III patients defects in a subunit of the GlcNAc-1-phosphotransferase complex lead to the missorting of several lysosomal enzymes. This in turn causes an accumulation of non-degradable cell material within the lysosomes resulting in typical symptoms like skeletal changes or heart valve abnormalites.

Project website "Mucolipidosis Typ II and III" (Prof. Thomas Braulke/ Dr. Sandra Pohl)

ESGDL website