2nd funding period of Research Unit FOR2625 approved
End of September the German Research Foundation approved the 2nd funding period of the Research Unit FOR 2625 "Mechanisms of Lysosomal Homeostasis" with a funding volume of 3.98 million euro.
The Research Unit was established in October 2017 and consists of eleven German and one Dutch research groups. It aims at elucidating the biogenesis, functions and turnover of lysosomes as a whole, and protein-protein and lipid-protein interactions at the cytosolic surface of lysosomes. Analysing the molecular mechanisms that maintain lysosomal homeostasis will contribute to understand the cause of lysosomal disorders, thereby enabling the development of long-term preclinical therapeutic strategies.
Participating Researchers of the second funding period: Thomas Braulke (Hamburg), Anja Bremm (Frankfurt/Main), Markus Damme (Kiel), Ivan Dikic (Frankfurt/Main), Volker Haucke (Berlin), Christian Hübner (Jena), Thomas Jentsch (Berlin), Judith Klumperman (Utrecht, NL), Tassula Proikas-Cezanne (Tübingen), Paul Saftig (Kiel), Tobias Stauber (Hamburg), Dominic Winter (Bonn)
Invitation to FOR2625 Symposium LYSOSOMES & AUTOPHAGY
NEW DATE: April 29 - 30, 2021
Max Delbrück Communications Center, Berlin-Buch
Due to the coronavirus outbreak the FOR2625 symposium is postponed from June 2020 to April 2021!
The members of the Research Unit FOR2625 "Mechanisms of Lysosomal Homeostasis" invite scientists from all over the world to join our International FOR2625 Symposium on LYSOSOMES & AUTOPHAGY.
Outstanding scientists have confirmed their participation in our two-day program and will present their newest findings on the molecular machinery of the endo-lysosomal system and autophagy. The symposium offers a great opportunity for young and more advanced researchers to meet internationally renowned experts and discuss their projects during scientific sessions as well as during social events.
Registration will open on November 16, 2020 und is limited to 160 participants.
For further information please visit www.lysosomes2021.de
Invitation to FOR2625 Seminar with Margaret S. Robinson (CIMR, UK)
Margaret S. Robinson - Cambridge Institute for Medical Research (UK)
AP-4 and AP-5: the mystery adaptors and their role in autophagy and lysosomal homeostasis
Due to the corona virus outbreak this seminar -originally scheduled for March 2020- is postponed. The new date will be announced on this website as soon as possible.
University Hospital Jena
Building F2 (FUI), seminar room 10
Am Klinikum 1, 07743 Jena
Lena Westermann wins two presentation prizes
Our medical student and doctoral candidate Lena Westermann was honored at two conferences for her presentations. In March her poster presentation entitled
Targeting of pro-osteoclastogenic interleukin-6 in mucolipidosis type II as a potential corrective approach was awarded with the Dr. Ursula Wachtel Poster prize at the "Jahrestagung der Arbeitsgemeinschaft für Pädiatrische Stoffwechselerkrankungen (APS)" in Fulda. In addition Lena won the Free Communication Award at the 50. EMG (European Metabolic Group) Conference, that took place in June in Hamburg.
Research for Rare: Study by Schulz et al. highlighted as Paper of the Month
The recently pushlished study by Angela Schulz and colleagues "Study of intraventricular Cerliponase Alfa for CLN2 disease" that was conducted within the frame of our research consortium NCL2TREAT is highlighted as Paper of the Month on the website of the research network "Research for Rare -German networks on rare diseases". The rare lysosomal storage disorder CLN2 is a late-infantile form of neuronal ceroid lipofuscinoses and is characterized by epilepsy, loss of speech, vision and motoric skills, and by early death. The study by Schulz et al. was published in the
New England Journal of Medicine and could show that an enzyme replacement therapy using the recombinant enzyme tripeptidyl peptidase 1 (cerliponase alfa) could positively influence the course of the disease and even stop the loss of motor and language function in a subset of patients.
NCL2TREAT portrayed in Research for Rare newsletter
The latest issue of the Research for Rare newsletter includes a potrait feature on our research network NCL2TREAT. (Article in German only.)
Giorgia Di Lorenzo awarded at 21st ESGLD Meeting in Lyon
Our PhD student Giorgia Di Lorenzo received the Young Scientist Award at the 21. meeting of the "European Study Group on Lysosomal Disorders" (September 14th - 17th 2017, Lyon/France). She was awarded in the categorie "best oral presentation" for her talk entitled
Role of the gamma-subunit of GlcNAc-1-phosphotransferase in the pathogenesis of mucolipidosis type III.
As part of her PhD project Giorgia Di Lorenzo investigates the molecular mechanisms that lead to the lysosomal storage disorder mucolipidosis type III, an inherited metabolic disease that is caused by defects in the GlcNAc-1-phosphotransferase complex. This enzyme complex plays a key role in generating the mannose 6-phosphate recognition marker on lysosomal enzymes which is essential for their efficient transport to lysosomes. In mucolipidosis type III patients defects in a subunit of the GlcNAc-1-phosphotransferase complex lead to the missorting of several lysosomal enzymes. This in turn causes an accumulation of non-degradable cell material within the lysosomes resulting in typical symptoms like skeletal changes or heart valve abnormalites.