The Institute of Systems Immunology was established 2021 at the Center for Molecular Neurobiology Hamburg (ZMNH) under the leadership of Prof. Dr. Immo Prinz.
We are exploring the development, homeostasis, and function of innate lymphocytes such as NK cells and γδ T cells. These cells likely play an important role in the immediate immune response to invading pathogens. The focus of our group is clearly the investigation of γδ T cells, in particular of the mechanisms that lead to their differentiation into interferon-γ or interleukin-17 producing effector cells. Thereby, we are very interested in the role of the γδ TCR and the relation of TCR specificity and γδ T cell function. To this end, we established protocols for high-throughput TCR sequencing. Furthermore, we investigate the dynamics of γδ T cells using a TcrdH2BeGFP reporter „knock-in“ system, which allows us to track γδ T cells by means of an intrinsic bright green fluorescence in their nuclei. In parallel, we are generating additional „knock-in“ und „knock-out” models to study the function of γδ T cells and other innate lymphocytes.