Research at the Institute of Immunology

The working group on Virus Immunology at the UKE and HPI , headed by Prof. Dr. Marcus Altfeld, investigates protective innate and adaptive immune responses against viruses that infection humans. Research projects characterize the mechanisms by which these viruses are recognized by the immune system and how viruses try to avoid antiviral immunity. The goal of these studies to identify those innate and adaptive immune responses that are either associated with protection against new infections, the clearance of established infections, or with more favorable disease outcome of chronically persistent infections

The working group on Moleculare Immunology , headed by Prof. Dr. Friedrich Koch-Nolte, is focused on the molecular characterization of lymphocyte membrane proteins, in particular receptors and enzymes involved in signaling by extracellular nucleotides. The laboratory of Prof. Nolte generates monoclonal and single domain antibodies as new research and therapeutic tools.

The working group on Immune Regulation , headed by Prof. Dr. Eva Tolosa, is focused on the regulation of autoimmune diseases.

The working group on Signal Transduction and Clinical Immunology , headed by Prof. Dr. Friedrich Haag, is focused on the molecular characterization of lymphocyte membrane proteins, in particular receptors and enzymes involved in signaling by extracellular nucleotides.
Because of the close connection to the Clinical Immunodiagnostics Laboratory the group is also interested in evaluating and improving immunodiagnostic methods suitable for routine use.

The working group on Infection Immunology , headed by Prof. Dr. Hans-Willi Mittrücker, is focused on the regulation of immune responses against pathogens and on the function of T cells in autoimmune kidney diseases.