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Immune-mediated glomerular diseases (Glomerulonephritides, GN) are a major and constantly increasing cause of end-stage renal diseases worldwide and are associated with significant morbidity and mortality. Fundamental to each form of GN is a pathogenic immune response against renal autoantigens or the local manifestations of systemic autoimmunity in the kidney, resulting in glomerular injury, proteinuria and various degrees of renal functional decline. Current therapeutic strategies usually aim at broadly suppressing the immune system, often do not halt or reverse the disease and are frequently associated with disabling side effects. We have established the Collaborative Research Center (CRC) 1192 to dissect immune-mediated glomerular diseases at the molecular, cellular, systemic and individual level to ultimately bridge the translational gap between experimental studies and improved patient outcomes within the 12-year funding perspective and beyond.

Here you can find more information about the CRC 1192

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The SFB1328 "Adenine Nucleotides in Immunity and Inflammation" focuses on cellular and molecular signaling processes in inflammation and immunity. The aim is to decipher the role of a novel class of siganling molecules in inflammatory processes and in the immune response. In addition to basic research-oriented projects, the development of new diagnostic and therapeutic methods is also a focus.

Here you can find more information about the CRC 1328

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Healthy pregnancies are essential to a healthy society. Maternal immune adaptation sustains the maintenance of healthy pregnancies by mounting immune tolerance towards the foetus. This immune adaptation emerged from the evolution of placental mammals over thousands of years. Yet, we now live in an environment characterised by a modern lifestyle (e.g., changes in diet, obesity, psychological stress), along with a rapidly changing infectious landscape. These environmental conditions are not in sync with the evolutionary selected maternal immune adaptation during pregnancy and can threaten maternal and foetal well-being by causing maternal immune activation (MIA).

Here you can find more information about the CRC 1713

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Low bone mineral density is a common finding in the older population, yet it can also appear before the age of 50 years, which is often accompanied by fractures and reduced quality of life. Many of the individuals with early-onset low bone mineral density were identified to carry mutations in specific genes, which are required for the proper function of bone cells. Our clinical research unit (ProBone) has the aim to identify the causes of early-onset low bone mineral density in individual patients in order to establish the best personalized treatment. We will also perform molecular studies to understand the function of specific genes in the skeleton and to establish novel treatment options in the future.

Here you can find more information about the CRU 5029

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Stroke is the primary cause of long-term disability and the third leading cause of death in industrialized countries. In Germany, the annual incidence of stroke is above 250,000. The lifetime risk of experiencing a stroke ranges from 8% to 10% and continues to rise due to demographic changes. Current treatments for stroke are limited, and preclinical experimental findings often fail in clinical trials. Hence, new avenues of basic research with high translation potential are desperately needed in order to develop effective therapeutic strategies. The neuroinflammatory response after ischemic brain injury has been well established as a key pathomechanisms in stroke. While neuroinflammatory mechanisms have been described in great detail for the acute phase after ischemic brain injury, mechanisms of brain-immune interaction during the chronic recovery phase as well as consequences of immunomodulatory interventions for post-stroke recovery are barely understood. Therefore, this research unit will focus on studying the role of immunity in repair mechanisms and long-term recovery following stroke.

Here you can find more information about the RU 2879

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Differences in immune responses between men and women lead to variations in the prevalence, severity and manifestation of autoimmune diseases, infections and tumours. As part of the research group, scientists from the UKE, LIV, FZ Borstel, BNITM and DKFZ are investigating how gender-specific differences influence the immune response.

Here you can find more information about the RU 5068

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DZIF's mission is to coordinate and strategically align translational infection research with the aim of developing new diagnostic, preventative and therapeutic methods for treating infectious diseases. The UKE is part of the Hamburg-Borstel-Lübeck DZIF site. Prof. Altfeld is a member of the TTU HIV within the DZIF, and several of Prof. Altfeld‘s research projects on HIV-1 pathogenesis and Cure research are funded by the DZIF.

Here you can find more information about the DZIF .

The HORUS project unites solid organ transplantation (SOT) experts, computational data scientists, virologists and immunologists in a fully operating European network consisting of 24 partners.

Here you can find more information about HORUS

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Together with Berlin, the Hamburg site coordinates the research focus on Rare genetic diseases and makes its drug development platform available to all DZKJ sites. In addition, Hamburg coordinates the research area of CNS development and neurological diseases together with Göttingen and makes significant contributions to the research areas of Immunity, Inflammation, Infection, Psychosocial and mental health and Early determinants of health and disease. Participating institutions at the site are the University Medical Center Hamburg-Eppendorf and the Leibniz Institute of Virology.

Here you can find more information about the DZKJ