Current Projects

MIA (SFB1713)
Title: SFB on Immune adaptation and activation during pregnancy
Study biometrician: Antonia Zapf
Funding: DFG (SFB)
Duration: 01.10.2025 - 30.06.2029

GET-FAST
Title: Goettingen/German Endovascular Trial For A Swift Thrombectomy (GET-FAST)
Study biometrician: Antonia Zapf
Funding: DFG
Duration: 01.01.2025 - 31.12.2027

METARIS-AKI
Title: Meta-analysis based on individual patient data for the identification and stratification of risk factors for the development of functional and structural acute kidney injury phenotypes following cardiac surgery
Study biometrician: Antonia Zapf
Funding: Dr. Werner Jackstädt-Stiftung
Duration: 01.010.2025 - 31.12.2025

EAST-STROKE
Title: Early Rhythm Control in Acute Ischemic Stroke Patients with AF
Study biometrician: Antonia Zapf
Funding: DFG, HORIZON
Duration: 01.12.2024 - 30.11.2030

CONTOUR
Title: Towards a more standardized bicuspid aortic valve repair: impact of active aortic annulus remodeling on 4D MRI flow patterns and functional outcome of aortic valve repair
Study biometrician: Antonia Zapf
Funding: Else Kröner Fresenius Stiftung
Duration: 01.10.2024 - 30.09.2028

SCOPE-D
Title: Systematic Care of Patients with Depression in General Practice: A guideline-oriented cluster-randomized intervention using an online self-help program
Study biometrician: Antonia Zapf
Funding: BMBF
Duration: 15.09.2024 - 30.04.2028

ReSCInD
Title: Reduction of SystemiC Inflammation after ischemic stroke by intravenous DNase administration
Study biometrician: Antonia Zapf
Funding: Else Kröner Fresenius Stiftung
Duration: 01.09.2024 - 30.09.2026

DETECT II
Title: Continuous finger-cuff arterial pressure monitoring and intraoperative hypotension in non-cardiac surgery patients: the randomized DETECT II trial
Study biometrician: Antonia Zapf
Funding: Industry
Duration: 15.04.2024 - 30.06.2026

Fat-dlsCT
Title: The aim of this project is to evaluate new techniques of fat quantification by dual-layer spectral-CT (dlsCT), which were developed in previous projects of the applicant, in clinical studies
Study biometrician: Antonia Zapf
Funding: DFG
Duration: 12.02.2024 - 31.12.2026

Survivorship
Title: The Hamburg "Life After Cancer Programme": Development, implementation and evaluation of a structured survivorship programme – a hybrid effectiveness implementation study
Study biometrician: Antonia Zapf
Funding: Deutsche Krebshilfe
Duration: 01.01.2024 - 31.12.2027

PASSION
Title: Thrombolysis with TenectePlase in Acute iSchemic Stroke Patients taking dIrect Oral aNticoagulants – a multicenter randomized placebo-controlled clinical trial
Study biometrician: Anna Suling
Funding: BMBF
Duration: 12.12.2023 - 30.06.2029

INTENSE
Title: Enhanced postoperative mobilization and bio tracking after colorectal oncological resection
Study biometrician: Antonia Zapf
Funding: Hamburger Krebsgesellschaft
Duration: 01.10.2023 - 30.09.2025

MethPASmultiE
Title: Methods for planning and evaluating studies with multiple time to event endpoints, taking into account recurring and competing events
Study biometrician: Ann-Kathrin Ozga
Funding: DFG
Duration: 01.08.2023 - 01.10.2026

Radiomics
Title: MRI radiomics-based long-term evaluation and identification of imaging biomarkers for growth prediction of distinct nodular lesions in plexiform neurofibromas in NF1
Study biometrician: Antonia Zapf
Funding: DFG
Duration: 01.07.2023 - 30.07.2026

BELI(E)VE
Title: Combination treatment of Belantamab Mafodotin and Venetoclax in treatment of relapsed and refractory t(11;14) Multiple Myeloma (Phase I/IIa)
Study biometrician: Antonia Zapf
Funding: Abbvie, GSK
Duration: 01.02.2023 - 31.12.2029

PELICAN
Title: Effect of personalized hemodynamic management targeting baseline cardiac index on postoperative complications and mortality in high-risk patients having major abdominal surgery: an international multicenter randomized controlled interventional clinical trial
Study biometrician: Antonia Zapf
Funding: Baxter
Duration: 01.02.2023 - 01.02.2026

TherVacB
Title: Open single center phase 1a trial to assess the safety and immunogenicity of a heterologous protein prime/MVA boost therapeutic hepatitis B vaccine candidate in healthy volunteers
Study biometrician: Antonia Zapf
Funding: Helmholtz
Duration: 01.01.2023 - 31.03.2026

ProTAC
Title: A multi-center interventional study to assess pharmacokinetics, effectiveness and tolerability of prolonged-release Tacrolimus after Paediatric Kidney Transplantation
Study biometrician: Antonia Zapf
Funding: Chiesi
Duration: 01.06.2022 - 31.03.2026

CBT-Sex in PD
Title: A Randomized Feasibility Study on the Efficacy of Cognitive Behavioral Sex Therapy as an Adjunct Short-Term Intervention for Men with Peyronie's Disease
Study biometrician: Anika Buchholz
Funding: European Society for Sexual Medicine
Duration: 14.04.2022 - 31.03.2026

UNLOAD_ECMO
Title: Left Ventricular Unloading to Improve Outcome in Cardiogenic Shock Patients on VA-ECMO (UNLOAD ECMO) - a randomized, controlled, single-centre, clinical trial
Study biometrician: Antonia Zapf
Funding: Industry
Duration: 01.04.2022 - 30.06.2029

EAST high
Title: Early atrial fibrillation ablation for stroke prevention in patients with high comorbidity burden
Study biometrician: Antonia Zapf
Funding: GCRFF
Duration: 01.04.2022 - 31.12.2030

MAESTRIA
Title: Machine Learning and Artificial Intelligence for Early Detection of Stroke and Atrial Fibrillation
Study biometrician: Antonia Zapf
Funding: EU Horizon 2020
Duration: 01.03.2021 - 31.08.2027

ACTICCA-2
Title: Radiofrequency ablation using transpapillary catheters in patients with cholangiocarcinoma
Study biometrician: Antonia Zapf
Funding: DFG
Duration: 01.03.2021 - 31.12.2026

CHAP
Title: Congenital Heart Adhesion Prophylaxis (CHAP) Study
Study biometrician: Antonia Zapf
Funding: Industry
Duration: 01.01.2021 - 01.12.2028

HEDOS
Title: Evaluation of the ISAR-M Thyro detector for diagnosing post-operative bleeding following thyroid surgery. Seamless design combining a Phase III diagnostic study and a Phase IV test-treatment study.
Study biometrician: Antonia Zapf
Funding: Industry
Duration: 03.09.2020 - 31.08.2026

STOPPIT
Title: Stop of proton-pump inhibitor treatment in patients with liver cirrhosis - a double-blind, placebo controlled trial
Study biometrician: Antonia Zapf
Funding: BMBF
Duration: 01.02.2018 - 31.12.2026

PEPPER
Title: Prospective, randomised study on personalised medicine with Pentaglobin following interventional focal treatment in patients with peritonitis
Study biometrician: Antonia Zapf
Funding: UK Aachen, Biotest AG
Duration: 01.10.2017 - 30.09.2028

CLOSURE-AF
Title: Left atrial appendage CLOSURE in patients with Atrial Fibrillation at high risk of stroke and bleeding compared to medical therapy: a prospective randomized clinical trial
Study biometrician: Karl Wegscheider
Funding: DZHK
Duration: 01.02.2016 - 30.09.2025

ACTICCA
Title: Adjuvant chemotherapy with gemcitabine and cisplatin compared to observation after curative intent resection of cholangiocarcinoma
Study biometrician: Antonia Zapf
Funding: DKH
Duration: 01.01.2014 - 30.06.2026