Working groups at the IOBM
Translational Osteology and Biomechanics & HistologieHistological section of bone in toluidine blue staining
Prof. Dr. med. Michael Amling
Dr. rer. nat. T. Yorgan
Dr.-Ing. M. Hahn
The section Translation & Histology is mainly concerned with the comprehensive histological analysis of bone and bone-associated cells. The focus lies on the translation of mechanical to biological signals, the patho-mechanisms of genetic disorders of the musculoskeletal system and the implant/biomaterial interface with bone.
Molecular Osteology and BiomechanicsMice vertebrae in histological section
Prof. Dr. rer. nat. Thorsten Schinke
Diverse signalling pathways influence bone accrual as well as skeletal quality and structure on the cellular and biochemical level. Basic principles of skeletal biology, causes of skeletal diseases and innovate therapeutic options are being investigated by utilizing appropriate in vitro and in vivo models. The direct interaction with the clinic facilitates a fast application of novel insights and continuously gives raises to new research initiatives.
Bioengineering / Medical TechnologySpatial distribution of bone mineral.
Univ.-Prof. Dr. rer. medic. Björn Busse
Pathological alterations in the structural integrity and elemental composition of the bone matrix impact fracture resistance significantly and thereby affect the patients health status. The aim of the Heisenberg Research Group is to decipher the underlying mechanisms at each level of bone’s complex hierarchical structure using a multiscale, integrated approach combining osseous cell imaging with bone quality assessment and medical imaging techniques.
Bone: local and systemic metabolismOsteoclast in scanning electron microscopy
Dr. Jean-Pierre David
Bone is not only building the skeleton but is also interacting with other organs. More specifically bone is homing hematopoiesis and is acting as an endocrine organ regulating adipose tissues. These tissues are themselves main regulators of bone homeostasis, thereby establishing a complex regulatory loop. As consequence, pathological alteration of bone should locally affect hematopoiesis and immune responses and, via its systemic effect, impact adipose tissue and therefore metabolism. The group is addressing these questions using multiple mouse models for bone diseases with the goal of improving the treatment of bone related diseases.