With our research, we gain novel insights into the mechanisms of neurological diseases. Neuropathology is at the hinge between basic and clinical neurosciences and our research combines molecular and cellular biology with disease models and human tissue specimens in a truly “translational” approach.
We focus on
Presenilin and Alzheimers disease
The role of neuroserpin in the brain
Developmental neurobiology and pediatric neurooncology
National Prion Diseases Reference Center (PRZ) by appointment of the German Society for Neuropathology and Neuroanatomy
The Institute of Neuropathology at the UKE acts as the German Prion Diseases Reference Center by appointment of the German Society for Neuropathology and Neuroanatomy.
Prion diseases (Creutzfeldt-Jakob Disease is humans) are progressive neurodegenerative diseases which can be sporadic (spontaneous with no known cause), familial (genetic/inherited with mutations in the prion protein gene) or acquired (transmitted by infection). They are rare with an average worldwide incidence (newly diagnosed patients per year) of approximately two cases per million people. Currently, there is no therapy for prion diseases.
The Prion Diseases Reference Center at the UKE:
-Identifies the precise type of prion disease (sporadic, familial, or acquired) by histological examination.
-Collaborates with the National Prion Diseases Reference of the Robert Koch Institute
-Performs research in the field of prion diseases ( Prof. Glatzel)
The aim of the UndoAD is to identify disease modifiers to explain the heterogeneity found in Alzheimer’s
disease. This will be achieved in the framework of a BMBF-supported Consortium which will establish standardized laboratory techniques and launch a common educational platform.
Partners of UndoAD are:
Prof. Dr. med. F. Lopera / Prof. Dr. med. Andres Villegas, Neurociencias-Gruppe der Universidad de Antioquia, Medellín, Kolumbien Leiter der Kolumbianischen Alzheimer Präventions-Studie (www.gna.org.co).
Prof. Dr. med. Inga Zerr , Leiterin der translationalen Demenzforschung am Deutschen Zentrum für Neurodegenerative Erkrankungen in Göttingen (TDG) (http://cjd-goettingen.de/)
Prof. Dr. M. Arcos-Burgos Universidad del Rosario D.C. Bogotá Kolumbien (https://plu.mx/urosario/u/marcosburgos)
Our Reference Center activities including research in prion diseases is not possible without a continuous support.
Donations are solely used for research on early diagnosis and development of therapy in prion diseases.
Donations can be made to the following account:
Accountholder: Universitätsklinikum Hamburg-Eppendorf
Bank: Hamburger Sparkasse,
IBAN : DE54200505501234363636
BIC/ Swift : HASPDEHHXXX
Please indicate “Neuropathology, 0917/030” as purpose