PD Dr. Christian Bernreuther FIS Profil
PD Dr. Jakob Matschke Researchgate Profil
Dr. sc. nat. Giovanna Galliciotti Researchgate Profil
Dr. rer. nat. Beata Puig Researchgate Profil
Alexander Hartmann Researchgate Profil
Christiane Muth FIS Profil
A main area of research in the Department of Neuropathology involves research on mechanisms of neurodegenerative diseases. Diseases studied are prion diseases, Alzheimer’s disease and familial encephalopathy with neuroserpin inclusions (FENIB) which share the common feature of protein deposits in the brain. Our research aims at answering the following questions:
- How does the disease spread in the organism?
- Which mechanisms link pathologic protein deposits with neurodegeneration?
- How can the diagnostic process be optimised with molecularpathologic methods?
A second area of research involves neurooncology. Different projects investigate genetic alterations in tumours of the nervous system, the immunobiology of brain tumours, and especially the neuropathology of neurofibromatosis. Current projects:
- Expression of neuronal marker proteins in brain tumors
- The role of CD44 in cell adhesion and migration in gliomas
- Expression of hyaluronic acid in glioma and peripheral nerve sheath tumours
Another area of research involves stem cell biology with special interest in protein degradation during differentiation of neural stem cells.
The Department of Neuropathology is part of the "Neuronal Protein Turnover" research group (spokesperson: Prof. Markus Glatzel), the Post-Graduate Study Program 1459 "Sorting and Interaction of Proteins of Subcellular Compartments" and the Leibnitz Graduate School on infectious diseases.
Experimental topics for doctoral theses are assigned to interested medical students, which will require at least nine months to complete working fulltime and at least one year when done parallel to medical school (including semester break and one free study trimester).