Publications

2021
Mahn M, Saraf-Sinik I, Patil P, Pulin M, Bitton E, Karalis N, Bruentgens F, Palgi S, Gat A, Dine J, Wietek J, Davidi I, Levy R, Litvin A, Zhou F, Sauter K, Soba P, Schmitz D, Lüthi A, Rost BR, Wiegert JS, Yizhar O.
Efficient optogenetic silencing of neurotransmitter release with a mosquito rhodopsin. Neuron. 2021 May 19;109(10):1621-1635.e8. doi: 10.1016/j.neuron.2021.03.013. Epub 2021 May 11.
Yang W, Chini M, Pöpplau JA, Formozov A, Dieter A, Piechocinski P, Rais C, Morellini F, Sporns O, Hanganu-Opatz IL, Wiegert JS.
Anesthetics fragment hippocampal network activity, alter spine dynamics, and affect memory consolidation. PLoS Biol. 2021 Apr 1;19(4):e3001146.
2020
Westermann LM, Fleischhauer L, Vogel J, Jenei-Lanzl Z, Floriano Ludwig N, Schau L, Morellini F, Baranowsky A, Yorgan TA, Di Lorenzo G, Schweizer M, de Souza Pinheiro B, Guarany NR, Sperb-Ludwig F, Visioli F, Oliveira Silva T, Soul J, Hendrickx G, Wiegert JS, Schwartz IVD, Clausen-Schaumann H, Zaucke F, Schinke T, Pohl S, Danyukova T.
Imbalanced cellular metabolism compromises cartilage homeostasis and joint function in a mouse model of mucolipidosis type III gamma.
Dis Model Mech. 2020 Nov 4;13(11)
Perez-Alvarez A, Fearey BC, O'Toole RJ, Yang W, Arganda-Carreras I, Lamothe-Molina PJ, Moeyaert B, Mohr MA, Panzera LC, Schulze C, Schreiter ER, Wiegert JS, Gee CE, Hoppa MB, Oertner TG.
Freeze-frame imaging of synaptic activity using SynTagMA.
Nat Commun. 2020 May 18;11(1):2464.
2019
Oppermann J, Fischer P, Silapetere A, Liepe B, Rodriguez-Rozada S, Flores-Uribe J, Peter E, Keidel A, Vierock J, Kaufmann J, Broser M, Luck M, Bartl F, Hildebrandt P, Wiegert JS, Béjà O, Hegemann P, Wietek J.
MerMAIDs: a family of metagenomically discovered marine anion-conducting and intensely desensitizing channelrhodopsins.
Nat Commun. 2019 Jul 25;10(1):3315.
Dürst CD, Wiegert JS, Helassa N, Kerruth S, Coates C, Schulze C, Geeves MA, Török K, Oertner TG. High-speed imaging of glutamate release with genetically encoded sensors.
Nat Protoc. 2019 May;14(5):1401-1424.
Yizhar O, Wiegert JS.
Designer Drugs for Designer Receptors: Unlocking the Translational Potential of Chemogenetics.
Trends Pharmacol Sci. 2019 May 6. pii: S0165-6147(19)30087-2.
2018
Wiegert, J.S., Pulin, M., Gee, C.E., Oertner , T. G. The fate of hippocampal synapses depends on the sequence of plasticity-inducing events. eLife 7 (2018)
Oda, K., Vierock, J., Oishi, S., Rodriguez-Rozada, S., Taniguchi, R., Yamashita, K., Wiegert, J.S., Nishizawa, T., Hegemann, P., Nureki, O. Crystal structure of the red light-activated channelrhodopsin Chrimson. Nat Commun (2018)
Helassa, N., Dürst, C.D., Coates, C., Arif, U., Schulze, C., Wiegert, J.S., Geeves, M., Oertner, T.G., Török, K. Fast glutamate sensors resolve short-term synaptic plasticity, Proc Natl Acad Sci USA (2018)
2017
Bitzenhofer, S.H., Ahlbeck, J., Wolff, A. Wiegert, J.S., Gee, C.E., Oertner, T.G., Hanganu-Opatz, I.L. (2017). Layer-specific optogenetic activation of pyramidal neurons causes beta-gamma entrainment of neonatal networks. Nat Comm 8:14563.
Wiegert, J. S., Gee, C.E., and Oertner, T. G. (2017). Stimulating Neurons with Heterologously Expressed Light-Gated Ion Channels. Cold Spring Harb Protoc​ 2017 (2)
Gee, C.E., Ohmert, I., Wiegert, J. S., and Oertner, T. G. (2017). Preparation of Slice Cultures from Rodent Hippocampus. Cold Spring Harb Protoc​ 2017 (2)
Wiegert, J. S., Gee, C.E., and Oertner, T. G. (2017). Single-Cell Electroporation of Neurons. Cold Spring Harb Protoc​ 2017 (2)
Wiegert, J. S., Gee, C.E., and Oertner, T. G. (2017). Viral Vector-Based Transduction of Slice Cultures. Cold Spring Harb Protoc​ 2017 (2)
Wiegert, J.S., Mahn, M., Prigge, M., Printz, Y., and Yizhar, O. (2017) Silencing Neurons: Tools, Applications, and Experimental Constraints. Neuron 95:504-529.
2016
Wiegert, J. S. and Oertner T. G. (2016). How (not) to silence long-range projections with light. Nat Neurosci 19(4): 527-528
2015
Wietek, J., Beltramo, R., Scanziani, M., Hegemann, P., Oertner, T.G., Wiegert, J.S. (2015). An improved chloride-conducting channelrhodopsin for light-induced inhibition of neuronal activity in vivo. Sci Rep 5: 14807
Wiegert, J.S. and Oertner, T.G. (2015). Neighborly synapses help each other out. Nat Neurosci 18, 326-327
Blumer, C., Vivien, C., Genoud, C., Perez-Alvarez, A., Wiegert, J.S., Oertner, T.G., Vetter, T. (2015). Automated analysis of spine dynamics on live CA1 pyramidal cells. Med Image Anal 19(1), 87-97
2014
Wietek, J.*, Wiegert, J.S.*, Adeishvili, N., Schneider, F., Watanabe, H., Tsunoda, S., Vogt, A., Elstner, M., Oertner, T.G., Hegemann, P. (2014). Conversion of Channelrhodopsin into a light-gated chloride channel. Science 344 (6182): 409-412,
*equal contributions
Biermann, B., Sokoll, S., Klyueva, J., Missler, M., Wiegert, J.S., Sibarita, J.-B., Heine, M. (2014). Imaging of molecular surface dynamic in brain slices using single particle tracking. Nat Commun 5:3024
2013
Wiegert, J.S. and Oertner , T. G. (2013). Long-term depression selectively eliminates weakly integrated synapses. Proc Natl Acad Sci USA 110(47), E4510-E4519
2012
Huber, D., Gutnisky, D.A., Peron, S., O'Connor, D.H., Wiegert, J.S., Tian, L., Oertner, T.G., Looger, L.L., and Svoboda, K. (2012). Multiple dynamic representations in the motor cortex during sensorimotor learning. Nature 484, 473-478
2011
Queisser, G., Wiegert, J.S., Bading, H. (2011). Structural dynamics of the cell nucleus. Nucleus 2(2), 1-7
Wiegert, J. S. and Oertner , T. G. (2011). Shapeshifting for memory. e-Neuroforum 2(1), 6-12
Wiegert, J.S. and Bading, H. (2011). Activity-dependent calcium signaling and ERK-MAP kinases in neurons: a link to structural plasticity of the nucleus and gene transcription regulation. Cell Calcium 49, 296-305
2010
Holbro, N., Grunditz, A., Wiegert, J.S., and Oertner, T.G. (2010). AMPA receptors gate spine Ca2+ transients and spike-timing-dependent potentiation. Proc Natl Acad Sci USA 107(36), 15975-15980
2009
Wittmann, M., Queisser, G., Eder, A., Wiegert, J.S., Bengtson, C.P., Hellwig, A., Wittum, G., and Bading, H. (2009). Synaptic activity induces dramatic changes in the geometry of the cell nucleus: interplay between nuclear structure, histone H3 phosphorylation, and nuclear calcium signaling. J Neurosci 29, 14687-14700. (first 6 authors equally contributing)
Wiegert, J.S., Hofmann, F., Bading, H., and Bengtson, C.P. (2009). A transcription-dependent increase in miniature EPSC frequency accompanies late-phase plasticity in cultured hippocampal neurons. BMC Neurosci 10, 124
2007
Wiegert, J.S., Bengtson, C.P., and Bading, H. (2007). Diffusion and not active transport underlies and limits ERK1/2 synapse-to-nucleus signaling in hippocampal neurons. J Biol Chem 282, 29621-29633