ZMNH scientist was awarded NENS Poster Award 2018

Best poster winner Brenna Fearey
Laureate Brenna Fearey

The Network of European Neuroscience Schools (NENS) awards at every Forum of the Federation of European Neuroscience Societies (FENS) a best poster award. During this year’s FENS Forum in Berlin from July 7th-11th, 2018, Brenna Fearey, a doctoral student in the Institute of Synaptic Physiology of ZMNH/UKE, received the first prize for her poster “SynTagMA: A synaptic tag for mapping activity”. She presented a new genetic tool that marks active synapses by red fluorescence whereas non-active synapses show green fluorescence. With this contribution, she won the first prize, a great success in a conference with more than 7,000 participants!

Summary: SynTagMA, a synaptic tag for mapping activity
Brenna Fearey (1), Alberto Perez-Alvarez (1), Christian Schulze (1), Ignacio Arganda-Carreras (2), Eric Schreiter (3), J. Simon Wiegert (4), Christine Gee (1), Thomas Oertner (1)
1 Institute of Synaptic Physiology, Center for Molecular Neurobiology (ZMNH), UKE, Hamburg
2 Universidad del Pais Vasco, Computer Science and Artificial Intelligence, San Sebastian, Spain
3 Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, USA
4 Synaptic Wiring and Information Processing, ZMNH, UKE, Hamburg
Whether synaptic weight changes or changes in network connectivity underlie learning and memory has been difficult to determine due to the lack of a reliable method to monitor all active connections over time. CaMPARI is a genetically encoded calcium integrator that allows permanent labeling of highly active cells by UV illumination. By anchoring CaMPARI to dendritic spines using a PSD-95 FingR, we created SynTagMA: a genetically encoded photo-convertible calcium integrator targeted to the post-synapse. Upon UV illumination, SynTagMA irreversibly photoconverts from green to red, but only in spines with high calcium levels. To characterize and calibrate this tool, we expressed the cytosolic CaMPARI or the newly made SynTagMA in CA1 pyramidal cells in organotypic hippocampal slice cultures. We show that the precise timing and dosage of UV illumination is crucial for labeling synaptic events. As this tool allows simultaneous analysis of thousands of synapses in tissue, we are developing a streamlined image analysis process. Due to natural protein turnover, it is possible generate a second map of active synapses 24 h later. Thus, it will be possible to study the pattern of active synapses at multiple time points. We hope that our new tool will allow investigation of the stability of synaptic circuits following long-term potentiation in vitro and in intact animals during behavior.

July 12, 2018

New potential therapeutic target for AutismSpectrum disorder

Intensive research under the direction of Dr. Froylan Calderon de Anda, Research Group Neuronal Development at the Center for Molecular Neurobiology (ZMNH) of the University Medical Center Hamburg-Eppendorf (UKE), revealed that mutations in the TAO2 gene leading to a reduced gene activity result in an increased risk for autism spectrum disorders (ASDs). The scientists identified RhoA signaling as a mediator of TAOK2-dependent synaptic development that has the potential for a new therapeutic target for ASDs.

Reference: Richter et al., Altered TAOK2 activity causes autism-related neurodevelopmental 3 and cognitive abnormalities through RhoA signaling, Molecular Psychiatry, 2018, DOI:

Press release of UKE (in German)

Resonance in international press



April 4, 2018

Michael Frotscher - "But, research requires much time.“

Prof. Dr. med. Dr. h.c. Michael Frotscher
Prof. Dr. med. Dr. h.c. Michael Frotscher

Our colleague and friend Prof. Dr. med. Dr. h.c. Michael Frotscher died after a short serious illness on May 27th, 2017. We will greatly miss his friendly, appreciative manner, his scientific expertise and his tireless efforts to address difficult questions.

With the passing of Michael Frotscher, we have lost an internationally acclaimed scientist and a wonderful colleague who never lost his curiosity of how the brain works.

In 2011, Michael Frotscher came to Hamburg with a Senior Research Professorship in Neuroscience from the Hertie Foundation and established the Institute for Structural Neurobiology at the Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE). He was elected Director of the ZMNH in 2015.

He quickly became a highly esteemed member of the Medical Faculty of Universität Hamburg, and a valued advisor and discussion partner for colleagues from diverse areas who greatly appreciated his readiness to help and his specialist advice.

Michael Frotscher’s scientific work on the cytoarchitecture and wiring of the brain as well as on the structural and functional analysis of synapses is internationally renowned and highly cited. Innumerable collaborations, honorary positions and awards demonstrate his very high reputation. In recognition of his important contributions to the field of neuroanatomy, he received many awards including: the Gottfried Wilhelm Leibniz Prize of the German Research Council (DFG), the Ernst Jung Prize for Medicine, an honorary doctorate from the Goethe University Frankfurt and the Jacob Henle Medal of the Georg-August-Universität Göttingen.

We will treasure our memories of Michael Frotscher, an outstanding scientist and wonderful friend whose heart beat for science. Our thoughts are with his relatives.

His colleagues

Curriculum Vitae Prof. Dr. Dr. h.c. Michael Frotscher

June 1, 2017

ZMNH scientist was awarded an ERC Starting Grant

Dr. J. Simon Wiegert from the ZMNH Institute for Synaptic Physiology was awarded an ERC Starting Grant from the European Research Council (ERC) for his project “LIFE synapses – Long-term Investigation of Functional Excitatory Synapses: Linking Plasticity, Network Wiring and Memory Storage”. The project aims at deciphering the role of synapses for information processing and memory storage in the mammalian brain by combining state-of-the-art imaging techniques such as 2-photon microscopy with latest optogenetic approaches. The grant amounts to € 1.5 million for a period of five years.

Press release of the University Medical Center Hamburg-Eppendorf (in German, pdf)

October 7, 2016

Dr. Martini Prize for ZMNH scientist

Dr. Xuejun Chai from the ZMNH Institute for Structural Neurobiology is laureate of a second Dr. Martini Prize 2016. The prize was awarded for her research on the role of Reelin for the induction of branching of neurons and radial glial cells during corticogenesis. The Dr. Martini Prize is the oldest prize for scientific research in the field of medicine in Germany. It is annually awarded by the Dr. Martini-Foundation to scientists working in Hamburg.

Press release of the University Medical Center Hamburg-Eppendorf (in German, pdf)

February 12, 2016

Honorary doctorate degree of Universität Heidelberg

Honorary Doctoral Degree of Universität Heidelberg for Prof. Schachner
Award Ceremony for Prof. Dr. Schachner at Universität Heidelberg

On November 30, 2015, Melitta Schachner Camartin, one of the world’s leading neuroscientists, received the prestigious honorary doctorate degree from the University of Heidelberg.

Schachner was the first chair of Heidelberg’s Department of Neurobiology from 1976 to 1988 and led the development of a center for neuroscience at Heidelberg. From 1988 she established a center for the study of neurobiology at Swiss Federal Institute of Technology in Zurich.

She was director of the ZMNH Institute for Neural Structures from 1995 to 2011 and is now head of the emeritus group Biosynthesis of Neural Structures, advisor for the Neuroscience Center at the Li Ka-Shing University Shantou, China and a Distinguished Professor in the Department of Cell Biology and Neuroscience, School of Arts and Sciences, Rutgers University–New Brunswick, USA,

A member of the prestigious German National Academy of Sciences Leopoldina, Schachner has focused her research on the cellular and molecular mechanisms that underlie development, maintenance, and modifications of the adult central nervous system. She has authored more than 800 articles in peer reviewed journals, her h-index was 118 in November 2015.

Press release of Universität Heidelberg (in German)

Press release of the University Medical Center Hamburg-Eppendorf (in German, pdf)

November 30, 2015

DFG Research Unit FOR 2419 "Plasticity versus Stability"

The German Research Foundation (DFG) has granted 2.5 million EUR for the Research Unit FOR 2419 "Plasticity versus Stability: Molecular Mechanisms of Synaptic Strength" which focusses on the longstanding question of synapse and network plasticity. The following seven research projects of ZMNH researchers are involved and coordinated by Prof. Dr. Matthias Kneussel:

Matthias Kneussel, ZMNH Institute for Molecular Neurogenetics
Delivery of plasticity-related proteins (PRPs) in synaptic consolidation

Marina Mikhaylova, Emmy Noether Group Neuronal Protein Transport
Functional interplay of microtubule and actin motors in dendritic compartmentalization

Wolfgang Wagner, ZMNH Institute for Molecular Neurogenetics
Mechanisms of actomyosin-dependent regulation of postsynaptic function and plasticity in Purkinje cells

Thomas Oertner, ZMNH Institute for Synaptic Physiology
Impact of spine endoplasmatic reticulum on synaptic function and plasticity

Froylan Calderon de Anda, ZMNH Junior Research Group Neuronal Development
The role of TAO2 in synapse formation and plasticity

MIchael Frotscher, ZMNH Institute for Structural Neurobiology
Structural plasticity of hippocampal mossy fiber synapses

Christine Gee and Simon Wiegert, ZMNH Institute for Synaptic Physiology
Dynamic rewiring of hippocampal circuits following synaptic plasticity

Press release of the DFG (in German)

October 1st, 2015