Applications from highly motivated undergraduates (medicine, natural sciences, bioinformatics...) that like to do a bachelor/master/ medical doctoral thesis work or be student helpers are always welcome.
Concerning PhD or post-doc positions, please ask to discuss the current possibilities in the lab.
Please note that we currently cannot accept student apprentices.
Can we use multidimensional data (e.g. from single cell transcriptomics or proteomics) to classify samples despite missing data? Yannis Schumann worked on a novel algorithm that makes this possible. The article "Robust classification using average correlations as features (ACF)" published in BMC Bioinformatics can be found at: https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-023-05224-0 . It was a joint work with the Chair of High Performance Computing at the HSU. Congratulations to Yannis!
Hannah Voß was awarded the first posterprize at the "Neurowoche 2022" in Berlin. She showed our data on proteomics in medulloblastoma. Congratulations!
Third in a row - Maximilian Middelkamp successfully defended his medical doctoral thesis today.
He did a great job and had published his results in Acta Neuropathologica Communications
( https://lnkd.in/guv4T3fJ ).
Congratulations from the whole team!
Piotr Sumislawski defended his dissertation successfully today. He had studied a rare type of embryonal eye cancer and had published his results together in Oncogenesis
Congratulations from the whole team!
We are on Twitter now! Check it out at
My first doctoral candidate Lisa Ruck successfully defended her doctoral thesis on the role of Lin28A during brain development!
Very happy to announce that our paper on the integration of "omics" data with missing values is now published in Nature communications https://lnkd.in/eT2zcXYm ( https://rdcu.be/cP0ns ). Our algorithm "HarmonizR" is free to use and can be found on GitHub. It allows the integration of independently generated Omic datasets and is of special interest for proteomic datasets that contain lots of missing values. This has been a great interdisciplinary collaboration with the Section Mass Spectrometry and Proteomics; UKE ( Prof. Hartmut Schlüters group ) and the Chair of High Performance Computing, Helmut Schmidt University ( Prof. Philipp Neumanns group ).
Great to be at the ISPNO2022 in Hamburg! We are happy to present our work on pediatric brain tumors and are enjoying great scientific talks.
Thanks to the team and our presenters Jelena Navolic, Matthias Dottermusch, Simon Schlumbohm and Maximilian Middelkamp!
Dr. Matthias Dottermusch
Applying spatial molecular profiling: Matthias' work an a case attributed to a new and rare brain tumor entity - so called central nervous system low-grade diffusely infiltrative tumour with INI1 deficiency (CNS LGDIT-INI1) - is out! It is titled "Spatial molecular profiling of a central nervous system low-grade diffusely infiltrative tumour with INI1 deficiency (CNS LGDIT-INI1) featuring a high-grade AT/RT component" and was published open access in Neuropathology and Applied Neurobiology ( https://onlinelibrary.wiley.com/doi/10.1111/nan.12777 ). Congratulations to Matthias!
LIN28A is expressed in some malignant brain tumors, such as ETMR or AT/RT. In their medical doctoral thesis, Max and Lisa were analyzing the effect of Lin28A overexpression during brain development and could show that Lin28A is not able to induce brain tumors. Their results could now be published open access in Acta Neuropathologica Communications titled: "Overexpression of Lin28A in neural progenitor cells in vivo does not lead to brain tumor formation but results in reduced spine density" ( https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-021-01289-1 ). Congratulations to both!
Price ceremony: The Hubertus-Wald Poster Award was handed over to Shweta Godbole for her work on integrating Omics data! Thanks to the University Cancer Center Hamburg ( UCCH ) and the Hubertus Wald Foundation for honouring the work of young scientists and congratulations to Shweta!
Matthias' und Piotrs work on the pathogenesis of embryonal eye cancer - so called intraocular medulloepithelioma - was accepted for open access publication in Oncogenesis. The work is titled : "Co-activation of Sonic hedgehog and Wnt signaling in murine retinal precursor cells drives ocular lesions with features of intraocular medulloepithelioma" ( https://rdcu.be/cBsQa ). In their work, Matthias and Piotr show that intraocular medulloepitheliomas are distinct from intracerebral medulloepitheliomas (also referred to as ETMR) and retinoblastomas with respect to gene expression profiles. Moreover, they describe the first preclinical in vivo model for this rare disease. Congratulations to both first authors !
Matthias' exciting case report concerning an uncommon SMARCB1 deficient tumor can be read in the diamond open access journal Free Neuropathology (www.freeneuropathology.org) titled "An atypical teratoid/rhabdoid tumor (AT/RT) with molecular features of pleomorphic xanthoastrocytoma (PXA) in a 62-year-old patient " ( https://www.uni-muenster.de/Ejournals/index.php/fnp/article/view/3640 ).
UCCH Research Retreat 2021:
Shweta Godbole received the UCCH Poster Award 2021 for her work on integrating multimodal omics data in medulloblastoma. Congratulations!
Here you will find current job offers and news to research at the Center for Molecular Neurobiology Hamburg (ZMNH).