Medical doctoral thesis:

We are looking for a medical student doing her /his doctoral thesis in our lab. The work focusses on the role of LIN28A in brain tumors. Generated preclinical models should be compared to human brain tumors based on histopathology and molecular parameters. Eligible students should be interested in histomorphology and the application of bioinformatical methods. Previous knowledge on the programming language R is helpful but not compulsive. Please send your applications to Prof. Dr. Julia Neumann (ju.neumann@uke.de).

Applications from highly motivated undergraduates (medicine, natural sciences, bioinformatics...) that like to do a lab rotations, bachelor/master/ medical doctoral thesis work or be student helpers are always welcome. Concerning PhD or post-doc positions, please ask to discuss the current possibilities in the lab.



Applying spatial molecular profiling: Matthias' work an a case attributed to a new and rare brain tumor entity - so called central nervous system low-grade diffusely infiltrative tumour with INI1 deficiency (CNS LGDIT-INI1) - is out! It is titled "Spatial molecular profiling of a central nervous system low-grade diffusely infiltrative tumour with INI1 deficiency (CNS LGDIT-INI1) featuring a high-grade AT/RT component" and was published open access in Neuropathology and Applied Neurobiology ( https://onlinelibrary.wiley.com/doi/10.1111/nan.12777 ). Congratulations to Matthias!


LIN28A is expressed in some malignant brain tumors, such as ETMR or AT/RT. In their medical doctoral thesis, Max and Lisa were analyzing the effect of Lin28A overexpression during brain development and could show that Lin28A is not able to induce brain tumors. Their results could now be published open access in Acta Neuropathologica Communications titled: "Overexpression of Lin28A in neural progenitor cells in vivo does not lead to brain tumor formation but results in reduced spine density" ( https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-021-01289-1 ). Congratulations to both!

Award Shweta
Hubertus-Wald Poster Award Shweta


Price ceremony: The Hubertus-Wald Poster Award was handed over to Shweta Godbole for her work on integrating Omics data! Thanks to the University Cancer Center Hamburg ( UCCH ) and the Hubertus Wald Foundation for honouring the work of young scientists and congratulations to Shweta!


Matthias' und Piotrs work on the pathogenesis of embryonal eye cancer - so called intraocular medulloepithelioma - was accepted for open access publication in Oncogenesis. The work is titled : "Co-activation of Sonic hedgehog and Wnt signaling in murine retinal precursor cells drives ocular lesions with features of intraocular medulloepithelioma" ( https://rdcu.be/cBsQa ). In their work, Matthias and Piotr show that intraocular medulloepitheliomas are distinct from intracerebral medulloepitheliomas (also referred to as ETMR) and retinoblastomas with respect to gene expression profiles. Moreover, they describe the first preclinical in vivo model for this rare disease. Congratulations to both first authors !


Matthias' exciting case report concerning an uncommon SMARCB1 deficient tumor can be read in the diamond open access journal Free Neuropathology (www.freeneuropathology.org) titled "An atypical teratoid/rhabdoid tumor (AT/RT) with molecular features of pleomorphic xanthoastrocytoma (PXA) in a 62-year-old patient " ( https://www.uni-muenster.de/Ejournals/index.php/fnp/article/view/3640 ).


UCCH Research Retreat 2021:
Shweta Godbole received the UCCH Poster Award 2021 for her work on integrating multimodal omics data in medulloblastoma. Congratulations!

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