In our department are located several trial centres of clinical trials for the german Society for Paediatric Oncology and Haematology. These are

Some patients have the opportunity to participate in experimental therapy studies, e.g. phase I/II-studies.

In the following fields research projects are pursued, partly in cooperation with other institutes.

1. Leukemia

2. Solid tumors and brain tumors

3. Bone marrow transplantation

4. Hemostasis

5. Late effects

Very important ist the collaboration with the Forschungsinstitut Kinderkrebs-Zentrum Hamburg, which was estabished in october 2006 and funded by the Fördergemeinschaft Kinderkrebszentrum Hamburg e.V. The Forschungsinstitut is located in the Heinrich-Pette-Institut close by our department. On 550 m² are modern laboratories and offices for us available.

The following working groups are established in the Forschungsinstitut Kinderkrebszentrum Hamburg:

1. Transcription regulation in leukemias ( Horstmann research group )

2. Communication in leukemias and neuroblastomas ( Nollau research group )

3. A laboratory model of how leukemia develops - APL as a model disease ( Sternsdorf research group )

4. Stem cell transplantation and immune therapy ( Müller research group )

5. Molecular pediatric neurooncology (research for brain tumors; working group will be developed)

Furthermore there are the following research projects:

  • the role of mutations of the tumorsuppressor genes p53 and RB1 (Retinoblastoma suppressor) for tumor developing in osteosarcoma
  • the interaction of mutations in the p53-gene with resistance to cytostatics in neuroblastoma
  • Tumor predispositioning syndromes (e.g. in Fanconi-anemia and Nijmwegen-Breakage-Syndrome)
  • MRD-diagnostics (Minimale residual disease) in acute leukemias
  • biochemical inactivation of the growth factor of leukemia cells asparagin with the medication asparaginase.
  • charakterization of a natural IgM-antibody against neuroblastoma cells

In cooperation with the physicians of our department, which are all involved in research projects, there are working 5 scientists, 12 medical-technical assistants und graduate students in laboratories in our department.

Furthermore there are 11 scientists, 6 graduate students and 5 technical assistants at the Forschungsinstitut Kinderkrebs-Zentrum Hamburg.