The Research Group Neuronal Protein Transport was established 2015 at the Center for Molecular Neurobiology Hamburg (ZMNH) under the direction of Dr. Marina Mikhaylova.

Since June 2020 Marina Mikhaylova is Professor of Optobiology at the IfB at the Humboldt University of Berlin.

Coworker of the Research Group at ZMNH

Prof. Dr. Marina MikhaylovaRG-Leader  
Dr. Anja KonietznyPostdoc+49(0) 40 7410 - 55069Room 1.34
Yuhao HanPhD Student+49(0) 40 7410 - 55069Room 1.34

Research Focus

Neuronal synapses form the basis for neuronal communication and the storage of information in brain. The strength and persistence of chemical synapses are tightly regulated and the plastic properties of neighbored dendritic synapses are also determined by molecular and electrical signaling in dendritic segments. Potentiation of a dendritic spine favors the potentiation of its neighbor. In this regard, the dendritic branch forms a perfect compartment for confined signaling. The overall aim of our lab is to understand what defines a dendritic segment as a "plasticity unit" and what are the underlying molecular mechanisms of heterosynaptic plasticity. We take a multidisciplinary approach by combining electrophysiology with advanced imaging techniques and biochemical/molecular biological methods to tackle two main questions: 1. How are synaptic proteins involved in interactions between nearby synapses and how do they contribute to the establishment of clustered synaptic plasticity within a dendritic branch? 2. What is the role of dendritic secretory trafficking organelles like ER-Golgi intermediate compartment (ERGIC), the dendritic Golgi satellite system, retromer and endosomal systems in establishment and maintenance of dendritic compartments? In this respect understanding how the interplay between motor proteins allows for controlled cargo delivery, retention or release in response to synaptic activity in dendritic branch compartments might be of key importance.



  • Spike-timing-dependent plasticity rewards synchrony rather than causality.Anisimova M, van Bommel B, Wang R, Mikhaylova M, Simon Wiegert J, Oertner TG, Gee CE.Cereb Cortex. 2022 Feb 24:bhac050. doi: 10.1093/cercor/bhac050. Online ahead of print.
  • Direct and indirect effects of tubulin post-translational modifications on microtubule stability: Insights and regulations.Bär J, Popp Y, Bucher M, Mikhaylova M.Biochim Biophys Acta Mol Cell Res. 2022 Jun;1869(6):119241. doi: 10.1016/j.bbamcr.2022.119241.
  • Caldendrin and myosin V regulate synaptic spine apparatus localization via ER stabilization in dendritic spines.Konietzny A, Grendel J, Kadek A, Bucher M, Han Y, Hertrich N, Dekkers DHW, Demmers JAA, Grünewald K, Uetrecht C, Mikhaylova M.EMBO J. 2022 Feb 15;41(4):e106523. doi: 10.15252/embj.2020106523.
  • Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies. Linsenmeier L, Mohammadi B, Shafiq M, Frontzek K, Bär J, Shrivastava AN, Damme M, Song F, Schwarz A, Da Vela S, Massignan T, Jung S, Correia A, Schmitz M, Puig B, Hornemann S, Zerr I, Tatzelt J, Biasini E, Saftig P, Schweizer M, Svergun D, Amin L, Mazzola F, Varani L, Thapa S, Gilch S, Schätzl H, Harris DA, Triller A, Mikhaylova M, Aguzzi A, Altmeppen HC, Glatzel M. Sci Adv. 2021 Nov 26;7(48):eabj1826.

  • Multiomics of synaptic junctions reveals altered lipid metabolism and signaling following environmental enrichment. Borgmeyer M, Coman C, Has C, Schött HF, Li T, Westhoff P, Cheung YFH, Hoffmann N, Yuanxiang P, Behnisch T, Gomes GM, Dumenieu M, Schweizer M, Chocholoušková M, Holčapek M, Mikhaylova M, Kreutz MR, Ahrends R. Cell Rep. 2021 Oct 5;37(1):109797.
  • Autism-associated SHANK3 missense point mutations impact conformational fluctuations and protein turnover at synapses. Bucher M, Niebling S, Han Y, Molodenskiy D, Hassani Nia F, Kreienkamp HJ, Svergun D, Kim E, Kostyukova AS, Kreutz MR, Mikhaylova M. Elife. 2021 May 4;10:e66165.

  • Actomyosin Contractility in the Generation and Plasticity of Axons and Dendritic Spines. Mikhaylova M, Rentsch J, Ewers H. Cells. 2020 Sep 1;9(9):2006.
  • Cyclase-associated protein 2 dimerization regulates cofilin in synaptic plasticity and Alzheimer's disease.
    Pelucchi S, Vandermeulen L, Pizzamiglio L, Aksan B, Yan J, Konietzny A, Bonomi E, Borroni B, Padovani A, Rust MB, Di Marino D, Mikhaylova M, Mauceri D, Antonucci F, Edefonti V, Gardoni F, Di Luca M, Marcello E. Brain Commun. 2020 Jun 26;2(2):fcaa086.

  • Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis.Marques ARA, Di Spiezio A, Thießen N, Schmidt L, Grötzinger J, Lüllmann-Rauch R, Damme M, Storck SE, Pietrzik CU, Fogh J, Bär J, Mikhaylova M, Glatzel M, Bassal M, Bartsch U, Saftig P. Autophagy. 2020 May;16(5):811-825.

  • Cytoskeletal makeup of the synapse: Shaft versus spine. Bucher M, Fanutza T, Mikhaylova M. Cytoskeleton (Hoboken). 2020 Mar;77(3-4):55-64.

  • Conserved Tao Kinase Activity Regulates Dendritic Arborization, Cytoskeletal Dynamics, and Sensory Function in Drosophila.
    Hu C, Kanellopoulos AK, Richter M, Petersen M, Konietzny A, Tenedini FM, Hoyer N, Cheng L, Poon CLC, Harvey KF, Windhorst S, Parrish JZ, Mikhaylova M, Bagni C, Calderon de Anda F, Soba P. J Neurosci. 2020 Feb 26;40(9):1819-1833.

  • Actomyosin Contractility in the Generation and Plasticity of Axons and Dendritic Spines. Mikhaylova M, Rentsch J, Ewers H. Cells. 2020 Sep 1;9(9):2006.
  • Radial somatic F-actin organization affects growth cone dynamics during early neuronal development. Meka DP, Scharrenberg R, Zhao B, Kobler O, König T, Schaefer I, Schwanke B, Klykov S, Richter M, Eggert D, Windhorst S, Dotti CG, Kreutz MR, Mikhaylova M, Calderon de Anda F. EMBO Rep. 2019 Oct 24:e47743.
  • Myosin V regulates synaptopodin clustering and localization in dendrites of hippocampal neurons. Konietzny A, González-Gallego J, Bär J, Perez-Alvarez A, Drakew A, Demmers JAA, Dekkers DHW, Hammer JA 3rd, Frotscher M, Oertner TG, Wagner W, Kneussel M, Mikhaylova M. . J Cell Sci. 2019 Aug 1. pii: jcs.230177.
  • F-actin patches associated with glutamatergic synapses control positioning of dendritic lysosomes. van Bommel B, Konietzny A, Kobler O, Bär J, Mikhaylova M. EMBO J. 2019 Jun 27:e101183.
  • Clinical relevance of cytoskeleton associated proteins for ovarian cancer.
    Schiewek J, Schumacher U, Lange T, Joosse SA, Wikman H, Pantel K, Mikhaylova M, Kneussel M, Linder S, Schmalfeldt B, Oliveira-Ferrer L, Windhorst S.
    J Cancer Res Clin Oncol. 2018 Nov;144(11):2195-2205.
  • In vivo regulation of the A disintegrin and metalloproteinase 10 (ADAM10) by the tetraspanin 15. Seipold L, Altmeppen H, Koudelka T, Tholey A, Kasparek P, Sedlacek R, Schweizer M, Bär J, Mikhaylova M, Glatzel M, Saftig P. Cell Mol Life Sci. 2018 Mar 8.
  • Caldendrin directly couples postsynaptic calcium signals to actin-remodeling in dendritic spines. Mikhaylova M, Bär J, van Bommel B, Schätzle P, YuanXiang PY, Raman R, Hradsky J, Konietzny A, Loktionov EY, Reddy PP, Lopez-Rojas J, Spilker C, Kobler O, Raza SA, Stork O, Hoogenraad CC, Kreutz MR. Neuron. 2018.01.046.
  • Strong fascin expressionpromotes metastasis independent of its F-actin bundling activity.
    Heinz LS, Muhs S, Schiewek J, Grüb S, Nalaskowski M, Lin YN, Wikman H, Oliveira-Ferrer L, Lange T, Wellbrock J, Konietzny A, Mikhaylova M, Windhorst S.
    Oncotarget. 2017 Nov 1;8(66):110077-110091.
  • Microtubules Modulate F-actin Dynamics during Neuronal Polarization.
    Zhao B, Meka DP, Scharrenberg R, König T, Schwanke B, Kobler O, Windhorst S, Kreutz MR, Mikhaylova M, Calderon de Anda F. Sci Rep. 2017 Aug 29;7(1):9583.
  • Posttranslational modification impact on the mechanism by which amyloid-β induces synaptic dysfunction. Grochowska KM, Yuanxiang P, Bär J, Raman R, Brugal G, Sahu G, Schweizer M, Bikbaev A, Schilling S, Demuth HU, Kreutz MR. EMBO Rep. 2017
  • Periodic F-actin structures shape the neck of dendritic spines. Bär J, Kobler O, van Bommel B, Mikhaylova M. Sci Rep. 2016 Nov 14;6:37136.
  • A Jacob/Nsmf Gene Knockout Results in Hippocampal Dysplasia and Impaired BDNF Signaling in Dendritogenesis. Spilker C, Nullmeier S, Grochowska KM, Schumacher A, Butnaru I, Macharadze T, Gomes GM, Yuanxiang P, Bayraktar G, Rodenstein C, Geiseler C, Kolodziej A, Lopez-Rojas J, Montag D, Angenstein F, Bär J, D'Hanis W, Roskoden T, Mikhaylova M, Budinger E, Ohl FW, Stork O, Zenclussen AC, Karpova A, Schwegler H, Kreutz MR. . PLoS Genet. 2016 Mar 15;12(3):e1005907.
  • A plasmid based expression system to study protein-protein interactions at the Golgi in vivo. Bera S, Raghuram V, Mikhaylova M, Kreutz MR. Anal Biochem. 2016 Mar 10.
  • Alternative Splicing, Expression and Cellular Localization of Calneuron-1 in the Rat and Human Brain. Hradsky J, Bernstein HG, Marunde M, Mikhaylova M, Kreutz MR.
    Brain.J Histochem Cytochem. 2015 Oct;63(10):793-804.