Datenschutz
Institute of Developmental Neuroscience
Our research focuses on the mechanisms underlying the development of neuronal networks under physiological and pathophysiological conditions. In particular, we aim to elucidate how patterns of early electrical activity control local and long-range wiring in the brain in relationship with the emergence of cognitive behavior and (multi)sensory perception.
We have pioneered the functional dissection of neuronal circuits during development using in vivo electrophysiology and optogenetics. We showed that dynamic interactions between neurons early in life not only shape the adult brain function and behavior but are also of paramount importance for circuit miswiring and disabilities in mental disorders.
Visit Institute Website | UKE
www.opatzlab.comMore about Prof. Dr. Ileana Hanganu-Opatz
Prof. Dr. Ileana Hanganu-Opatz
KEY PUBLICATIONS
Blood pressure pulsations modulate central neuronal activity via mechanosensitive ion channels.L. J. Salameh, S. H. Bitzenhofer, I. L. Hanganu-Opatz, M. Dutschmann, V. Egger. Science 383(6682):eadk8511 (2024) Reorganization of adolescent prefrontal cortex circuitry is required for mouse cognitive maturation. J. A. Pöpplau, T. Schwarze, M. Dorofeikova, I. Pochinok, A. Günther, A. Marquardt, I. L. Hanganu-Opatz. Neuron 112(3):421-440 (2023) A transient developmental increase in prefrontal activity alters network maturation and causes cognitive dysfunction in adult mice. S. H. Bitzenhofer, J. A. Pöpplau, M. Chini, A. Marquardt, I.L. Hanganu-Opatz. Neuron 109(8):1350-1364 (2021) MORE INSTITUTES
