UKE - CENTER FOR MOLECULAR NEUROBIOLOGY HAMBURG - University Medical Ce

Institute of Molecular Neurogenetics

We investigate how neuronal activity and intracellular trafficking of synaptic molecules intertwine. We ask how synapses crosstalk to cytoskeletal elements to direct plasticity-related proteins across neurons. Combining biochemical, cellular and mouse behavioral approaches, we also study non-canonical neuronal communication through extracellular vesicles and unravel mechanisms of neuronal dysfunction.

We recently identified a subcellular mechanism that controls the direction of protein targeting from synapses to either the lysosome or multivesicular body/exosome pathway. Our lab showed that posttranslational modification of tubulin controls neuronal transport underlying the regulation of working and associative memory.

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More about Prof. Dr. Matthias Kneussel
Prof. Dr. Matthias Kneussel

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KEY PUBLICATIONS

Disruption of tubulin-alpha4a polyglutamylation prevents aggregation of hyper-phosphorylated tau and microglia activation in mice. T. J. Hausrat, P. C. Janiesch, P. Breiden, D. Lutz, S. Hoffmeister-Ullerich, I. Hermans-Borgmeyer, A. V. Failla, M. Kneussel. Nat Commun.13(1):4192 (2022)

Muskelin Coordinates PrPC Lysosome versus Exosome Targeting and Impacts Prion Disease Progression. F. F. Heisler, Y. Pechmann, I. Wieser, H. C. Altmeppen, L. Veenendaal, M. Muhia, M. Schweizer, M. Glatzel, S. Krasemann, M. Kneussel. Neuron. 99, 1155–1169.e9 (2018)

Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory. T. J. Hausrat, M. Muhia, K. Gerrow, P. Thomas, W. Hirdes, S. Tsukita, F. F. Heisler, L. Herich, S. Dubroqua, P. Breiden, J. Feldon, J. R. Schwarz, B. K. Yee, T. G. Smart, A. Triller, M. Kneussel. Nat Commun. 6, 6872 (2015)