UKE - CENTER FOR MOLECULAR NEUROBIOLOGY HAMBURG - University Medical Ce

Institute of Neuroimmunology and Multiple Sclerosis

We want to understand the aetiology and pathogenesis of multiple sclerosis and other neuroimmunological or neuroinfectious diseases and to translate this knowledge into efficacious treatments. We investigate the immune and the central nervous system and their interactions to understand mechanisms of immune cell dysregulation and neurodegeneration.

We were able to identify inflammation-induced neuronal response patterns that resulted in ion channel dysfunction, energy deficit, toxic protein deposition and ferroptosis, together driving neuronal injury and disease progression. These can now be therapeutically targeted.

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More about Prof. Dr. Manuel Friese
Prof. Dr. Manuel Friese

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MANUEL FRIESE

Director - Institute of Neuroimmunology and Multiple Sclerosis

KEY PUBLICATIONS

STING orchestrates the neuronal inflammatory stress response in multiple sclerosis. M. S. Woo, C. Mayer, L. Binkle-Ladisch, J. K. Sonner, S. C. Rosenkranz, A. Shaposhnykov, N. Rothammer, V. Tsvilovskyy, S. M. Lorenz, L. Raich, L. C. Bal, V. Vieira, I. Wagner, S. Bauer, M. Glatzel, M. Conrad, D. Merkler, M. Freichel, M. A. Friese. Cell. 187(15):4043-4060.e30 (2024)

G9a dictates neuronal vulnerability to inflammatory stress via transcriptional control of ferroptosis. N. Rothammer, M. S. Woo, S. Bauer, L. Binkle-Ladisch, G. Di Liberto, K. Egervari, I. Wagner, U. Haferkamp, O. Pless, D. Merkler, J. B. Engler, M. A. Friese. Sci Adv. 8, eabm5500 (2022)

Identifying CNS-colonizing T cells as potential therapeutic targets to prevent progression of multiple sclerosis.M. Kaufmann, H. Evans, A. L. Schaupp, J. B. Engler, G. Kaur, A. Willing, N. Kursawe, C. Schubert, K. E. Attfield, L. Fugger, M. A. Friese. Med (N Y). 2, 296–312.e8 (2021)