We want to understand the aetiology and pathogenesis of multiple sclerosis and other neuroimmunological or neuroinfectious diseases and to translate this knowledge into efficacious treatments. We investigate the immune and the central nervous system and their interactions to understand mechanisms of immune cell dysregulation and neurodegeneration.
We were able to identify inflammation-induced neuronal response patterns that resulted in ion channel dysfunction, energy deficit, toxic protein deposition and ferroptosis, together driving neuronal injury and disease progression. These can now be therapeutically targeted.
www.inims.de |
UKE
More about Prof. Dr. Manuel Friese
Prof. Dr. Manuel Friese