Generation of novel models: We design, establish and analyse new models for certain aspects of pathogenetic mechanisms in HD.
'omics: We generate and analyse 'big data' in the context of HD. These datasets come from various biological sources and we use state-of-the-art technologies and bioinformatics to evaluate and integrate the 'omics datasets.
RNA biology: We are interested in the contribution of RNA-based mechanisms to cell (type specific) toxicity in HD. In particular we try to unravel mechanisms that contribute to the incomplete splicing of the HTT mRNA.
Extracellular Vesicles: EV biology is disturbed in HD. Our findings offer new insights into HD biology and molecular mechanisms contributing to disease progression, as well as the use of EVs as attractive biomarkers in the context of clinical trials.