We are especially interested in the mechanisms of neuroinvasion of SARS-CoV 2, on how SARS-CoV 2 leads to neurological symptoms and on the long-term consequences COVID-19 has in the CNS.
COVID-19 caused by the novel coronavirus SARS-CoV 2 leads to acute and chronic neurological symptoms, yet it is unclear if and how SARS-CoV 2 damages the brain and if this has long-term consequences for the CNS. We address this experimentally using a translational approach studying clinical data and data obtained by analyzing tissue of patients suffering from COVID-19. For this we employ a wide spectrum of techniques from biochemistry to histochemistry, high-end imaging techniques and novel omics based analyses.
Marked reactive activation of microglia (HLA-DR) with occasional microglia nodules (black arrow). Infiltration of T lymphocytes (CD8). Scarce presence of SARS-CoV-2 proteins in isolated cells within the CNS and in cranial nerves.