2023

Cryo-EM structures of actin binding proteins as tool for drug discovery
Dahlstroem C, Paraschiakos T, Sun H, Windhorst S
BIOCHEM PHARMACOL. 2023;214:115680.

The actin bundling activity of ITPKA mainly accounts for its migration-promoting effect in lung cancer cells
Küster L, Paraschiakos T, Karakurt K, Schumacher U, Diercks B, Windhorst S
BIOSCIENCE REP. 2023;43(2):.

Ex Vivo Model of Neuroblastoma Plasticity
Schäfer P, Muhs S, Turnbull L, Garwal P, Maar H, Yorgan T, Tolosa E, Lange T, Windhorst S
CANCERS. 2023;15(4):.

Structural basis for subversion of host cell actin cytoskeleton during Salmonella infection
Yuan B, Scholz J, Wald J, Thuenauer R, Hennell James R, Ellenberg I, Windhorst S, Faix J, Marlovits T
SCI ADV. 2023;9(49):eadj5777.

2022

DIAPH1 facilitates paclitaxel-mediated cytotoxicity of ovarian cancer cells
Flat W, Borowski S, Paraschiakos T, Blechner C, Windhorst S
BIOCHEM PHARMACOL. 2022;197:.

Key Role of Hyaluronan Metabolism for the Development of Brain Metastases in Triple-Negative Breast Cancer
Hamester F, Stürken C, Legler K, Eylmann K, Möller K, Roßberg M, Gorzelanny C, Bauer A, Windhorst S, Schmalfeldt B, Laakmann E, Müller V, Witzel I, Oliveira-Ferrer L
CELLS-BASEL. 2022;11(20):.

2021

2-Methoxyestradiol and its derivatives inhibit store-operated Ca2+ entry in T cells: identification of a new and potent inhibitor
Löhndorf A, Hosang L, Dohle W, Odoardi F, Waschkowski S, Rosche A, Bauche A, Winzer R, Tolosa E, Windhorst S, Marry S, Flügel A, Potter B, Diercks B, Guse A
BBA-MOL CELL RES. 2021;1868(6):118988.

DIAPH1 regulates chromosomal instability of cancer cells by controlling microtubule dynamics
Miao S, Schäfer P, Nojszewski J, Meyer F, Windhorst S
EUR J CELL BIOL. 2021;100(3):.

Overexpression of Lin28A in neural progenitor cells in vivo does not lead to brain tumor formation but results in reduced spine density
Middelkamp M, Ruck L, Krisp C, Sumisławski P, Mohammadi B, Dottermusch M, Meister V, Küster L, Schlüter H, Windhorst S, Neumann J
ACTA NEUROPATHOL COM. 2021;9(1):185.

Mechanism of BIP-4 mediated inhibition of InsP3Kinase-A
Paraschiakos T, Flat W, Chen Y, Kirchmair J, Windhorst S
BIOSCIENCE REP. 2021;41(7):.

Oncogenic activity and cellular functionality of melanoma associated antigen A3
Schäfer P, Paraschiakos T, Windhorst S
BIOCHEM PHARMACOL. 2021;192:.

2020

Tubulin Tyrosine Ligase Like 4 (TTLL4) overexpression in breast cancer cells is associated with brain metastasis and alters exosome biogenesis
Arnold J, Schattschneider J, Blechner C, Krisp C, Schlüter H, Schweizer M, Nalaskowski M, Oliveira-Ferrer L, Windhorst S
J EXP CLIN CANC RES. 2020;39(1):205.

Physiological relevance of the neuronal isoform of inositol-1,4,5-trisphosphate 3-kinases in mice
Blechner C, Becker L, Fuchs H, Rathkolb B, Prehn C, Adler T, Calzada-Wack J, Garrett L, Gailus-Durner V, Morellini F, Conrad S, Hölter S, Wolf E, Klopstock T, Adamski J, Busch D, de Angelis M, Schmeisser M, Windhorst S
NEUROSCI LETT. 2020;735:135206.

Conserved Tao Kinase Activity Regulates Dendritic Arborization, Cytoskeletal Dynamics, and Sensory Function in Drosophila
Hu C, Kanellopoulos A, Richter M, Petersen M, Konietzny A, Tenedini F, Hoyer N, Cheng L, Poon C, Harvey K, Windhorst S, Parrish J, Mikhaylova M, Bagni C, Calderon de Anda F, Soba P
J NEUROSCI. 2020;40(9):1819-1833.

Modeling Spontaneous Bone Metastasis Formation of Solid Human Tumor Xenografts in Mice
Labitzky V, Baranowsky A, Maar H, Hanika S, Starzonek S, Ahlers A, Stübke K, Koziolek E, Heine M, Schäfer P, Windhorst S, Jücker M, Riecken K, Amling M, Schinke T, Schumacher U, Valentiner U, Lange T
CANCERS. 2020;12(2):.

Characterization of the substrate specificity of the inositol 5-phosphatase SHIP1
Nelson N, Wundenberg T, Lin H, Rehbach C, Horn S, Windhorst S, Jücker M
BIOCHEM BIOPH RES CO. 2020;524(2):366-370.

Mice lacking plastin-3 display a specific defect of cortical bone acquisition
Yorgan T, Sari H, Rolvien T, Windhorst S, Failla A, Kornak U, Oheim R, Amling M, Schinke T
BONE. 2020;130:115062.

2019

Inositol hexakisphosphate increases the size of platelet aggregates
Brehm M, Klemm U, Rehbach C, Erdmann N, Kolšek K, Lin H, Aponte-Santamaría C, Gräter F, Rauch B, Riley A, Mayr G, Potter B, Windhorst S
BIOCHEM PHARMACOL. 2019;161:14-25.

New options of cancer treatment employing InsP6
Brehm M, Windhorst S
BIOCHEM PHARMACOL. 2019;163:206-214.

The formin Drosophila homologue of Diaphanous2 (Diaph2) controls microtubule dynamics in colorectal cancer cells independent of its FH2-domain
Grueb S, Muhs S, Popp Y, Schmitt S, Geyer M, Lin Y, Windhorst S
SCI REP-UK. 2019;9(1):5352.

Radial somatic F-actin organization affects growth cone dynamics during early neuronal development
Meka D, Scharrenberg R, Zhao B, Kobler O, König T, Schaefer I, Schwanke B, Klykov S, Richter M, Eggert D, Windhorst S, Dotti C, Kreutz M, Mikhaylova M, Calderon de Anda F
EMBO REP. 2019;20(12):e47743.

The Actin Binding Protein Plastin-3 Is Involved in the Pathogenesis of Acute Myeloid Leukemia
Velthaus A, Cornils K, Hennigs J, Grüb S, Stamm H, Wicklein D, Bokemeyer C, Heuser M, Windhorst S, Fiedler W, Wellbrock J
CANCERS. 2019;11(11):.

2018

Effect of the actin- and calcium-regulating activities of ITPKB on the metastatic potential of lung cancer cells
Bäder S, Glaubke E, Grüb S, Muhs S, Wellbrock J, Nalaskowski M, Lange T, Windhorst S
BIOCHEM J. 2018;475(12):2057-2071.

Differential Proteome Analysis of Human Neuroblastoma Xenograft Primary Tumors and Matched Spontaneous Distant Metastases
Hänel L, Gosau T, Maar H, Valentiner U, Schumacher U, Riecken K, Windhorst S, Hansen N, Heikaus L, Wurlitzer M, Nolte I, Schlüter H, Lange T
SCI REP-UK. 2018;8(1):13986.

Clinical relevance of cytoskeleton associated proteins for ovarian cancer
Schiewek J, Schumacher U, Lange T, Joosse S, Wikman H, Pantel K, Mikhaylova M, Kneussel M, Linder S, Schmalfeldt B, Oliveira-Ferrer L, Windhorst S
J CANCER RES CLIN. 2018;144(11):2195-2205.

2017

Strong fascin expression promotes metastasis independent of its F-actin bundling activity
Heinz L, Muhs S, Schiewek J, Grüb S, Nalaskowski M, Lin Y, Wikman H, Oliveira-Ferrer L, Lange T, Wellbrock J, Konietzny A, Mikhaylova M, Windhorst S
ONCOTARGET. 2017;8(66):110077-110091.

Tight Junction Proteins Claudin-1 and Occludin Are Important for Cutaneous Wound Healing
Volksdorf T, Heilmann J, Eming S, Schawjinski K, Zorn-Kruppa M, Ueck C, Vidal-Y-Sy S, Windhorst S, Jücker M, Moll I, Brandner J
AM J PATHOL. 2017;187(6):1301-1312.

Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) is frequently over-expressed and functions as an oncogene in several tumor types
Windhorst S, Song K, Gazdar A
BIOCHEM PHARMACOL. 2017;137:1-9.

Microtubules Modulate F-actin Dynamics during Neuronal Polarization
Zhao B, Meka P, Scharrenberg R, König T, Schwanke B, Kobler O, Windhorst S, Kreutz M, Mikhaylova M, Calderon de Anda F
SCI REP-UK. 2017;7(1):9583.

2016

Smooth Muscle-Alpha Actin Inhibits Vascular Smooth Muscle Cell Proliferation and Migration by Inhibiting Rac1 Activity
Chen L, DeWispelaere A, Dastvan F, Osborne W, Blechner C, Windhorst S, Daum G
PLOS ONE. 2016;11(5):e0155726.

Control of aromatase in hippocampal neurons
Fester L, Brandt N, Windhorst S, Pröls F, Bläute C, Rune G
J STEROID BIOCHEM. 2016;160:9-14.

Inositol-1,4,5-trisphosphate-3-kinase-A controls morphology of hippocampal dendritic spines
Köster J, Leggewie B, Blechner C, Brandt N, Fester L, Rune G, Schweizer M, Kindler S, Windhorst S
CELL SIGNAL. 2016;28(1):83-90.

Diaphanous-related formin 1 as a target for tumor therapy
Lin Y, Windhorst S
BIOCHEM SOC T. 2016;44(5):1289-1293.

2015

The catalytic domain of inositol-1,4,5-trisphosphate 3-kinase-a contributes to ITPKA-induced modulation of F-actin
Ashour D, Pelka B, Jaaks P, Wundenberg T, Blechner C, Zobiak B, Failla A, Windhorst S
CYTOSKELETON. 2015;72(2):93-100.

Drosophila homologue of Diaphanous 1 (DIAPH1) controls the metastatic potential of colon cancer cells by regulating microtubule-dependent adhesion
Lin Y, Bhuwania R, Gromova K, Failla A, Lange T, Riecken K, Linder S, Kneussel M, Izbicki J, Windhorst S
ONCOTARGET. 2015;6(21):18577-89.

Ex vivo aorta patch model for analysis of cellular adhesion
Lin Y, Thata R, Failla A, Geissen M, Daum G, Windhorst S
TISSUE CELL. 2015;47(3):266-272.

The new InsP3Kinase inhibitor BIP-4 is competitive to InsP3 and blocks proliferation and adhesion of lung cancer cells
Schröder D, Tödter K, Gonzalez B, Franco-Echevarría E, Rohaly G, Blechner C, Lin H, Mayr G, Windhorst S
BIOCHEM PHARMACOL. 2015;96(2):143-50.

2014

Expression of DIAPH1 is up-regulated in colorectal cancer and its down-regulation strongly reduces the metastatic capacity of colon carcinoma cells
Lin Y, Izbicki J, König A, Habermann J, Blechner C, Lange T, Schumacher U, Windhorst S
INT J CANCER. 2014;134(7):1571-82.

Expression, Purification and preliminary X-Ray diffraction of a pathogenic bacterial protease from Stenotrophomonas maltophilia
Negm A, Windhorst S, Betzel C, Akrem A, Weber W
World J Pharm Pharm Sci. 2014;3(10):13-23.

Cellular internalisation of an inositol phosphate visualised by using fluorescent InsP5
Riley A, Windhorst S, Lin H, Potter B
CHEMBIOCHEM. 2014;15(1):57-67.

2013

Expression Regulation of the Metastasis-Promoting Protein InsP3-Kinase-A in Tumor Cells.
Chang L, Schwarzenbach H, Meyer-Staeckling S, Brandt B, Mayr G, Weitzel J, Windhorst S
MOL CANCER RES. 2013.

Combined targeting of AKT and mTOR using MK-2206 and RAD001 is synergistic in the treatment of cholangiocarcinoma
Ewald F, Grabinski N, Grottke A, Windhorst S, Nörz D, Carstensen L, Staufer K, Hofmann B, Diehl F, David K, Schumacher U, Nashan B, Jücker M
INT J CANCER. 2013;133(9):2065-76.

Malignant H1299 tumour cells preferentially internalize iron-bound inositol hexakisphosphate
Helmis C, Blechner C, Lin H, Schweizer M, Mayr G, Nielsen P, Windhorst S
BIOSCIENCE REP. 2013;33(5):.

Identification of a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A
Schröder D, Rehbach C, Seyffarth C, Neuenschwander M, Kries J, Windhorst S
BIOCHEM BIOPH RES CO. 2013;439(2):228-34.

Tumour cells can employ extracellular Ins(1,2,3,4,5,6)P(6) and multiple inositol-polyphosphate phosphatase 1 (MINPP1) dephosphorylation to improve their proliferation
Windhorst S, Lin H, Blechner C, Fanick W, Brandt L, Brehm M, Mayr G
BIOCHEM J. 2013;450(1):115-25.

2012

Inositol-1,4,5-trisphosphate 3-kinase A regulates dendritic morphology and shapes synaptic Ca2+ transients.
Windhorst S, Minge D, Bähring R, Hüser S, Schob C, Blechner C, Lin H, Mayr G, Kindler S
CELL SIGNAL. 2012;24(3):750-757.

2011

Human inositol 1,4,5-trisphosphate 3-kinase isoform B (IP3KB) is a nucleocytoplasmic shuttling protein specifically enriched at cortical actin filaments and at invaginations of the nuclear envelope.
Nalaskowski M, Fliegert R, Ernst O, Brehm M, Fanick W, Windhorst S, Lin H, Giehler S, Hein J, Lin Y, Mayr G
J BIOL CHEM. 2011;286(6):4500-4510.

Functional role of inositol-1,4,5-trisphosphate-3-kinase-A for motility of malignant transformed cells.
Windhorst S, Kalinina T, Schmid K, Blechner C, Kriebitzsch N, Hinsch R, Chang L, Herich L, Schumacher U, Mayr G
INT J CANCER. 2011;129(6):1300-1309.

2010

Inositol-1,4,5-trisphosphate-3-kinase-A is a new cell motility-promoting protein that increases the metastatic potential of tumour cells by two functional activities.
Windhorst S, Fliegert R, Blechner C, Möllmann K, Hosseini Z, Guenther T, Eiben M, Chang L, Lin H, Fanick W, Schumacher U, Brandt B, Mayr G
J BIOL CHEM. 2010;285(8):5541-5554.

2008

Ins(1,4,5)P3 3-kinase-A overexpression induces cytoskeletal reorganization via a kinase-independent mechanism.
Windhorst S, Blechner C, Lin H, Elling C, Nalaskowski M, Kirchberger T, Guse A, Mayr G
BIOCHEM J. 2008;414(3):407-417.

2007

Intracellular localization of human Ins(1,3,4,5,6)P5 2-kinase.
Brehm M, Schenk T, Zhou X, Fanick W, Lin H, Windhorst S, Nalaskowski M, Kobras M, Shears S, Mayr G
BIOCHEM J. 2007;408(3):335-345.

Radiosensitization of tumour cell lines by the polyphenol Gossypol results from depressed double-strand break repair and not from enhanced apoptosis.
Kasten-Pisula U, Windhorst S, Dahm-Daphi J, Mayr G, Dikomey E
RADIOTHER ONCOL. 2007;83(3):296-303.

2006

Subcellular localisation of human inositol 1,4,5-trisphosphate 3-kinase C: species-specific use of alternative export sites for nucleo-cytoplasmic shuttling indicates divergent roles of the catalytic and N-terminal domains.
Nalaskowski M, Windhorst S, Stockebrand M, Mayr G
BIOL CHEM. 2006;387(5):583-593.

2005

Antiproliferative plant and synthetic polyphenolics are specific inhibitors of vertebrate inositol-1,4,5-trisphosphate 3-kinases and inositol polyphosphate multikinase.
Mayr G, Windhorst S, Hillemeier K
J BIOL CHEM. 2005;280(14):13229-13240.

Letzte Aktualisierung aus dem FIS: 16.04.2024 - 06:32 Uhr