2025

Identification of Cannabidiolic and Cannabigerolic Acids as MTDL AChE, BuChE, and BACE-1 Inhibitors Against Alzheimer's Disease by In Silico, In Vitro, and In Vivo Studies
Vitale R, Morace A, D'Errico A, Ricciardi F, Fusco A, Boccella S, Guida F, Nasso R, Rading S, Karsak M, Caprioglio D, Iannotti F, Arcone R, Luongo L, Masullo M, Maione S, Amodeo P
PHYTOTHER RES. 2025;39(1):233-245.

2024

Germline mutations in a G protein identify signaling cross-talk in T cells
Ham H, Jing H, Lamborn I, Kober M, Koval A, Berchiche Y, Anderson D, Druey K, Mandl J, Isidor B, Ferreira C, Freeman A, Ganesan S, Karsak M, Mustillo P, Teo J, Zolkipli-Cunningham Z, Chatron N, Lecoquierre F, Oler A, Schmid J, Kuhns D, Xu X, Hauck F, Al-Herz W, Wagner M, Terhal P, Muurinen M, Barlogis V, Cruz P, Danielson J, Stewart H, Loid P, Rading S, Keren B, Pfundt R, Zarember K, Vill K, Potocki L, Olivier K, Lesca G, Faivre L, Wong M, Puel A, Chou J, Tusseau M, Moutsopoulos N, Matthews H, Simons C, Taft R, Soldatos A, Masle-Farquhar E, Pittaluga S, Brink R, Fink D, Kong H, Kabat J, Kim W, Bierhals T, Meguro K, Hsu A, Gu J, Stoddard J, Banos-Pinero B, Slack M, Trivellin G, Mazel B, Soomann M, Li S, Watts V, Stratakis C, Rodriguez-Quevedo M, Bruel A, Lipsanen-Nyman M, Saultier P, Jain R, Lehalle D, Torres D, Sullivan K, Barbarot S, Neu A, Duffourd Y, Similuk M, McWalter K, Blanc P, Bézieau S, Jin T, Geha R, Casanova J, Makitie O, Kubisch C, Edery P, Christodoulou J, Germain R, Goodnow C, Sakmar T, Billadeau D, Küry S, Katanaev V, Zhang Y, Lenardo M, Su H
SCIENCE. 2024;385(6715):eadd8947.

2022

Behavioral Studies of p62 KO Animals with Implications of a Modulated Function of the Endocannabinoid System
Keller C, Rading S, Bindila L, Karsak M
CELLS-BASEL. 2022;11(9):.

Impact of the Endocannabinoid System on Bone Formation and Remodeling in p62 KO Mice
Keller C, Yorgan T, Rading S, Schinke T, Karsak M
FRONT PHARMACOL. 2022;13:.

Editorial: Therapeutic potential of the cannabinoid CB2 receptor
Smoum R, Grether U, Karsak M, Vernall A, Park F, Hillard C, Pacher P
FRONT PHARMACOL. 2022;13:.

2021

Dynein Light Chain Protein Tctex1: A Novel Prognostic Marker and Molecular Mediator in Glioblastoma
Dumitru C, Brouwer E, Stelzer T, Nocerino S, Rading S, Wilkens L, Sandalcioglu I, Karsak M
CANCERS. 2021;13(11):2624.

Biallelic mutations in L-dopachrome tautomerase (DCT) cause infantile nystagmus and oculocutaneous albinism
Volk A, Hedergott A, Preising M, Rading S, Fricke J, Herkenrath P, Nürnberg P, Altmüller J, von Ameln S, Lorenz B, Neugebauer A, Karsak M, Kubisch C
HUM GENET. 2021;140(8):1157-1168.

The WNT1G177C mutation specifically affects skeletal integrity in a mouse model of osteogenesis imperfecta type XV
Vollersen N, Zhao W, Rolvien T, Lange F, Schmidt F, Sonntag S, Shmerling D, von Kroge S, Stockhausen K, Sharaf A, Schweizer M, Karsak M, Busse B, Bockamp E, Semler O, Amling M, Oheim R, Schinke T, Yorgan T
BONE RES. 2021;9(1):48.

2020

A rare heterozygous TREM2 coding variant identified in familial clustering of dementia affects an intrinsically disordered protein region and function of TREM2
Karsak M, Glebov K, Scheffold M, Bajaj T, Kawalia A, Karaca I, Rading S, Kornhuber J, Peters O, Diez-Fairen M, Frölich L, Hüll M, Wiltfang J, Scherer M, Riedel-Heller S, Schneider A, Heneka M, Fliessbach K, Sharaf A, Thiele H, Lennarz M, Jessen F, Maier W, Kubisch C, Ignatova Z, Nürnberg P, Pastor P, Walter J, Ramirez A
HUM MUTAT. 2020;41(1):169-181.

Monitoring Cannabinoid CB2 -Receptor Mediated cAMP Dynamics by FRET-Based Live Cell Imaging
Mensching L, Rading S, Nikolaev V, Karsak M
INT J MOL SCI. 2020;21(21):.

Mice carrying a ubiquitous R235W mutation of Wnt1 display a bone-specific phenotype
Yorgan T, Rolvien T, Stürznickel J, Vollersen N, Lange F, Zhao W, Baranowsky A, Rosenthal L, Hermans-Borgmeyer I, Sharaf A, Karsak M, David J, Oheim R, Amling M, Schinke T
J BONE MINER RES. 2020;35(9):1726-1737.

2019

Integrity of Cajal-Retzius cells in the reeler-mouse hippocampus
Anstötz M, Karsak M, Rune G
HIPPOCAMPUS. 2019.

Acute Liver Injury after CCl4 Administration is Independent of Smad7 Expression in Myeloid Cells
Endig J, Unrau L, Sprezyna P, Rading S, Karsak M, Goltz D, Heukamp L, Tiegs G, Diehl L
INT J MOL SCI. 2019;20(22):.

Stable Adult Hippocampal Neurogenesis in Cannabinoid Receptor CB2 Deficient Mice
Mensching L, Djogo N, Keller C, Rading S, Karsak M
INT J MOL SCI. 2019;20(15):.

Systematic Affinity Purification Coupled to Mass Spectrometry Identified p62 as Part of the Cannabinoid Receptor CB2 Interactome
Sharaf A, Mensching L, Keller C, Rading S, Scheffold M, Palkowitsch L, Djogo N, Rezgaoui M, Kestler H, Moepps B, Failla A, Karsak M
FRONT MOL NEUROSCI. 2019;12:224.

Correction: Reelin controls the positioning of brainstem serotonergic raphe neurons
Shehabeldin R, Lutz D, Karsak M, Frotscher M, Krieglstein K, Sharaf A
PLOS ONE. 2019;14(1):e0211849.

2018

Cannabinoids in Glioblastoma Therapy: New Applications for Old Drugs
Dumitru C, Sandalcioglu I, Karsak M
FRONT MOL NEUROSCI. 2018;11:159.

Reelin controls the positioning of brainstem serotonergic raphe neurons
Shehabeldin R, Lutz D, Karsak M, Frotscher M, Krieglstein K, Sharaf A
PLOS ONE. 2018;13(7):e0200268.

2017

Evaluation of monoacylglycerol lipase as a therapeutic target in a transgenic mouse model of ALS
Pasquarelli N, Engelskirchen M, Hanselmann J, Endres S, Porazik C, Bayer H, Buck E, Karsak M, Weydt P, Ferger B, Witting A
NEUROPHARMACOLOGY. 2017;124:157-169.

2016

Cannabinoid receptor 2 expression modulates Gβ1γ2 protein interaction with the activator of G protein signalling 2/dynein light chain protein Tctex-1
Nagler M, Palkowitsch L, Rading S, Moepps B, Karsak M
BIOCHEM PHARMACOL. 2016;99:60-72.

Letzte Aktualisierung aus dem FIS: 21.03.2026 - 05:46 Uhr