Julian Schulze zur Wiesch
Priv.-Doz. Dr. med.
Julian Schulze zur Wiesch
MD
  • Senior physician
  • Leitender Oberarzt Sektion Infektiologie
  • Leiter Ambulanzzentrum Virushepatologie
  • Medical Specialist in Internal Medicine
Working area

Location

Campus Forschung N27 , 1st Floor, Room number 01.005
Languages
German (Mother tongue)

Areas of expertise

Publications

Zurück
  • 2020
  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • 2011
  • 2010
  • 2009
  • 2008
  • 2007
  • 2006
  • 2005
  • 2004
  • 2003
  • 2001
  • 1999
Vor

Has Increased Rollout of Direct Acting Antiviral Therapy Decreased the Burden of Late Presentation and Advanced Liver Disease in Patients Starting Hepatitis C Virus Therapy in Germany?

J CLIN GASTROENTEROL. 2020;54(2):192-199.

High rates of cirrhosis and severe clinical events in patients with HBV/HDV co-infection:longitudinal analysis of a German cohort: longitudinal analysis of a German cohort
Bockmann J, Grube M, Hamed V, von Felden J, Landahl J, Wehmeyer M, Giersch K, Hall M, Murray J, Dandri M, Lüth S, Lohse A, Lütgehetmann M, Schulze Zur Wiesch J
BMC GASTROENTEROL. 2020;20(1):24.

Treatment and re-treatment results of HCV patients in the DAA era
Piecha F, Gänßler J, Ozga A, Wehmeyer M, Dietz J, Kluwe J, Laschtowitz A, von Felden J, Sterneck M, Jordan S, Pischke S, Lohse A, Schulze Zur Wiesch J
PLOS ONE. 2020;15(5):e0232773.

HCV-specific CD4+ T cells of patients with acute and chronic HCV infection display high expression of TIGIT and other co-inhibitory molecules
Ackermann C, Smits M, Woost R, Eberhard J, Peine S, Kummer S, Marget M, Kuntzen T, Kwok W, Lohse A, Jacobs T, Boettler T, Schulze Zur Wiesch J
SCI REP-UK. 2019;9(1):10624.

Comparative Analysis of the Antiviral Effects Mediated by Type I and III Interferons in Hepatitis B Virus-Infected Hepatocytes
Bockmann J, Stadler D, Xia Y, Ko C, Wettengel J, Schulze Zur Wiesch J, Dandri M, Protzer U
J INFECT DIS. 2019;220(4):567-577.

Safety and efficacy of elvitegravir, dolutegravir, and raltegravir in a real-world cohort of treatment-naïve and -experienced patients
Brehm T, Franz M, Hüfner A, Hertling S, Schmiedel S, Degen O, Kreuels B, Schulze Zur Wiesch J
MEDICINE. 2019;98(32):e16721.

Efficacy of Retreatment After Failed Direct-acting Antiviral Therapy in Patients With HCV Genotype 1-3 Infections
Dietz J, Spengler U, Müllhaupt B, Schulze Zur Wiesch J, Piecha F, Mauss S, Seegers B, Hinrichsen H, Antoni C, Wietzke-Braun P, Peiffer K, Berger A, Matschenz K, Buggisch P, Backhus J, Zizer E, Boettler T, Neumann-Haefelin C, Semela D, Stauber R, Berg T, Berg C, Zeuzem S, Vermehren J, Sarrazin C
CLIN GASTROENTEROL H. 2019 [Epub ahead of print];31260-1.

Comprehensive Review of Human Plasmodium falciparum-Specific CD8+ T Cell Epitopes
Heide J, Vaughan K, Sette A, Jacobs T, Schulze Zur Wiesch J
FRONT IMMUNOL. 2019;10:397.

The Clinical Perspective on Hepatitis E
Horvatits T, Schulze Zur Wiesch J, Lütgehetmann M, Lohse A, Pischke S
VIRUSES. 2019;11(7):.

Reinfection with the hepatitis C virus in men who have sex with men after successful treatment with direct-acting antivirals in Germany: Current incidence rates compared with rates during the interferon era
Ingiliz P, Wehmeyer M, Boesecke C, Schulze Zur Wiesch J, Schewe K, Lutz T, Baumgarten A, Simon K, Hueppe D, Rockstroh J, Mauss S, Christensen S
CLIN INFECT DIS. 2019 [Epub ahead of print].

Mutations in Hepatitis D Virus Allow It to Escape Detection by CD8+ T Cells and Evolve at the Population Level
Karimzadeh H, Kiraithe M, Oberhardt V, Salimi Alizei E, Bockmann J, Schulze Zur Wiesch J, Budeus B, Hoffmann D, Wedemeyer H, Cornberg M, Krawczyk A, Rashidi-Alavijeh J, Rodríguez-Frías F, Casillas R, Buti M, Smedile A, Alavian S, Heinold A, Emmerich F, Panning M, Gostick E, Price D, Timm J, Hofmann M, Raziorrouh B, Thimme R, Protzer U, Roggendorf M, Neumann-Haefelin C
GASTROENTEROLOGY. 2019;156(6):1820-1833.

Detection of a Broad Range of Low-Level Major Histocompatibility Complex Class II-Restricted, Hepatitis Delta Virus (HDV)-Specific T-Cell Responses Regardless of Clinical Status
Landahl J, Bockmann J, Scheurich C, Ackermann C, Matzat V, Heide J, Nuurei T, D'Antonio G, von Felden J, Sette A, Peine S, Lohse A, Lütgehetmann M, Marget M, Sidney J, Schulze Zur Wiesch J
J INFECT DIS. 2019;219(4):568-577.

Diagnostic Accuracy of Noninvasive Markers of Steatosis, NASH, and Liver Fibrosis in HIV-Monoinfected Individuals at Risk of Nonalcoholic Fatty Liver Disease (NAFLD): Results From the ECHAM Study
Lemoine M, Assoumou L, De Wit S, Girard P, Valantin M, Katlama C, Necsoi C, Campa P, Huefner A, Schulze Zur Wiesch J, Rougier H, Bastard J, Stocker H, Mauss S, Serfaty L, Ratziu V, Menu Y, Schlue J, Behrens G, Bedossa P, Capeau J, Ingiliz P, Costagliola D
JAIDS-J ACQ IMM DEF. 2019;80(4):e86-e94.

Transjugular Intrahepatic Portosystemic Shunt: A Possible Risk Factor for Direct-Acting Antiviral Treatment Failure in Patients With Hepatitis C?
Piecha F, Gänßler J, Jordan S, Ergen C, Ittrich H, Kluwe J, Pischke S, Lohse A, Schulze Zur Wiesch J
Hepatol Commun. 2019;3(5):614-619.

Atypical memory B-cells are associated with Plasmodium falciparum anemia through anti-phosphatidylserine antibodies
Rivera-Correa J, Mackroth M, Jacobs T, Schulze Zur Wiesch J, Rolling T, Rodriguez A
ELIFE. 2019;8:.

Immediate versus deferred antiretroviral therapy in HIV-infected patients presenting with acute AIDS-defining events (toxoplasmosis, Pneumocystis jirovecii-pneumonia): a prospective, randomized, open-label multicenter study (IDEAL-study)
Schäfer G, Hoffmann C, Arasteh K, Schürmann D, Stephan C, Jensen B, Stoll M, Bogner J, Faetkenheuer G, Rockstroh J, Klinker H, Härter G, Stöhr A, Degen O, Bibiza-Freiwald E, Hüfner A, Jordan S, Schulze Zur Wiesch J, Addo M, Lohse A, van Lunzen J, Schmiedel S
AIDS RES THER. 2019;16(1):34.

Comparison of the integrin α4β7 expression pattern of memory T cell subsets in HIV infection and ulcerative colitis
Wittner M, Schlicker V, Libera J, Bockmann J, Horvatits T, Seiz O, Kummer S, Manthey C, Hüfner A, Kantowski M, Rösch T, Degen O, Huber S, Eberhard J, Schulze Zur Wiesch J
PLOS ONE. 2019;14(7):e0220008.

Mucosal-associated invariant T-cell frequency and function in blood and liver of HCV mono- and HCV/HIV co-infected patients with advanced fibrosis
Beudeker B, van Oord G, Arends J, Schulze Zur Wiesch J, van der Heide M, de Knegt R, Verbon A, Boonstra A, Claassen M
LIVER INT. 2018;38(3):458-468.

Epidemiology, clinical and laboratory features of 24 consecutive cases of leptospirosis at a German infectious disease center.
Brehm T, Schulze zur Wiesch J, Lütgehetmann M, Tappe D, Eisermann P, Lohse A, Addo M, Schmiedel S
INFECTION. 2018;46(6):847-853.

Levels of Cytokines in Serum Associate With Development of Hepatocellular Carcinoma in Patients With HCV Infection Treated With Direct-Acting Antivirals
Debes J, van Tilborg M, Groothuismink Z, Hansen B, Schulze Zur Wiesch J, von Felden J, de Knegt R, Boonstra A
GASTROENTEROLOGY. 2018;154(3):515-517.

Kombination von NAFLD Fibrosis Score und transienter Elastografie zur Identifikation mittelgradiger Fibrosestadien (II/III) bei nicht-alkoholischer Fettlebererkrankung
Drolz A, Wehmeyer M, Diedrich T, Piecha F, Schulze Zur Wiesch J, Kluwe J
Z GASTROENTEROL. 2018;56(1):43-50.

Lack of evidence for human serum albumin as major source of HEV infections
Horvatits T, Westhölter D, Peine S, Schulze Zur Wiesch J, Lohse A, Lütgehetmann M, Pischke S
TRANSFUSION MED. 2018;28(6):470-471.

Amino Acid Substitutions within HLA-B*27-Restricted T Cell Epitopes Prevent Recognition by Hepatitis Delta Virus-Specific CD8+ T Cells
Karimzadeh H, Kiraithe M, Kosinska A, Glaser M, Fiedler M, Oberhardt V, Salimi Alizei E, Hofmann M, Mok J, Nguyen M, van Esch W, Budeus B, Grabowski J, Homs M, Olivero A, Keyvani H, Rodríguez-Frías F, Tabernero D, Buti M, Heinold A, Alavian S, Bauer T, Schulze Zur Wiesch J, Raziorrouh B, Hoffmann D, Smedile A, Rizzetto M, Wedemeyer H, Timm J, Antes I, Neumann-Haefelin C, Protzer U, Roggendorf M
J VIROL. 2018;92(13):e01891-17.

Interactions Between KIR3DS1 and HLA-F Activate Natural Killer Cells to Control HCV Replication in Cell Culture
Lunemann S, Schöbel A, Kah J, Fittje P, Hölzemer A, Langeneckert A, Hess L, Poch T, Martrus G, Garcia-Beltran W, Körner C, Ziegler A, Richert L, Oldhafer K, Schulze Zur Wiesch J, Schramm C, Dandri M, Herker E, Altfeld M
GASTROENTEROLOGY. 2018;155(5):1366-1371.

HVEM and CD160: Regulators of Immunopathology During Malaria Blood-Stage
Muscate F, Stetter N, Schramm C, Schulze Zur Wiesch J, Bosurgi L, Jacobs T
FRONT IMMUNOL. 2018;9:2611.

Successful treatment of chronic hepatitis C with ground ledipasvir/sofosbuvir in a patient with Crohn's disease and short bowel syndrome
von Felden J, Scheurich C, Yamamura J, Brainard D, Mogalian E, Lohse A, Schulze Zur Wiesch J
J VIRAL HEPATITIS. 2018;25(2):214-215.

High efficacy of sofosbuvir/velpatasvir and impact of baseline resistance-associated substitutions in hepatitis C genotype 3 infection
von Felden J, Vermehren J, Ingiliz P, Mauss S, Lutz T, Simon K, Busch H, Baumgarten A, Schewe K, Hueppe D, Boesecke C, Rockstroh J, Daeumer M, Luebke N, Timm J, Schulze Zur Wiesch J, Sarrazin C, Christensen S
ALIMENT PHARM THER. 2018;47(9):1288-1295.

Editorial: genotype 3 HCV-who still needs ribavirin in a pan-genotypic era? Authors' reply.
von Felden J, Vermehren J, Schulze Zur Wiesch J, Sarrazin C, Christensen S
ALIMENT PHARM THER. 2018;47(11):1550-1551.

Real-world effectiveness of sofosbuvir-based treatment regimens for chronic hepatitis C genotype 3 infection: Results from the multicenter German hepatitis C cohort (GECCO-03)
Wehmeyer M, Ingiliz P, Christensen S, Hueppe D, Lutz T, Simon K, Schewe K, Boesecke C, Baumgarten A, Busch H, Rockstroh J, Schmutz G, Kimhofer T, Berger F, Mauss S, Schulze Zur Wiesch J
J MED VIROL. 2018;90(2):304-312.

HEV-positive blood donations represent a relevant infection risk for immunosuppressed recipients
Westhölter D, Hiller J, Denzer U, Polywka S, Ayuk F, Rybczynski M, Horvatits T, Gundlach S, Blöcker J, Schulze Zur Wiesch J, Fischer N, Addo M, Peine S, Göke B, Lohse A, Lütgehetmann M, Pischke S
J HEPATOL. 2018;69(1):36-42.

CD32 Expression of Different Memory T Cell Subpopulations in the Blood and Lymph Nodal Tissue of HIV Patients and Healthy Controls Correlates With Immune Activation
Wittner M, Dunay G, Kummer S, Bockhorn M, Hüfner A, Schmiedel S, Degen O, van Lunzen J, Eberhard J, Schulze Zur Wiesch J
JAIDS-J ACQ IMM DEF. 2018;77(4):345-349.

Stable Frequencies of HLA-C*03:04/Peptide-Binding KIR2DL2/3+ Natural Killer Cells Following Vaccination
Ziegler M, Grañana F, Garcia-Beltran W, Schulze Zur Wiesch J, Hoffmann C, Rechtien A, Lunemann S, Altfeld M
FRONT IMMUNOL. 2018;9:2361.

Long-term response after stopping tenofovir disoproxil fumarate in non-cirrhotic HBeAg-negative patients - FINITE study
Berg T, Simon K, Mauss S, Schott E, Heyne R, Klass D, Eisenbach C, Welzel T, Zachoval R, Felten G, Schulze-Zur-Wiesch J, Cornberg M, Op den Brouw M, Jump B, Reiser H, Gallo L, Warger T, Petersen J
J HEPATOL. 2017;67(5):918-924.

Liver Cirrhosis as a Risk Factor for Direct-Acting Antiviral Therapy Failure in Real-Life Hepatitis C Virus/Human Immunodeficiency Virus Coinfection
Boesecke C, Ingiliz P, Berger F, Lutz T, Schewe K, Schulze Zur Wiesch J, Baumgarten A, Christensen S, Rockstroh J, Mauss S
Open Forum Infect Dis. 2017;4(3):ofx158.

Autoantibodies against "rods and rings"-related IMPDH2 in hepatitis C genotype 1 and DAA therapy in a "real life" cohort
Dammermann W, Polywka S, Dettmann I, Mindorf S, Komorowski L, Wehmeyer M, Schulze Zur Wiesch J, Stöcker W, Lüth S
MED MICROBIOL IMMUN. 2017;206(5):379-382.

Ledipasvir plus sofosbuvir fixed-dose combination for 6 weeks in patients with acute hepatitis C virus genotype 1 monoinfection (HepNet Acute HCV IV) an open-label, single-arm, phase 2 study
Deterding K, Spinner C, Schott E, Welzel T, Gerken G, Klinker H, Spengler U, Wiegand J, Zur Wiesch J, Pathil A, Cornberg M, Umgelter A, Zöllner C, Zeuzem S, Papkalla A, Weber K, Hardtke S, von der Leyen H, Koch A, von Witzendorff D, Manns M, Wedemeyer H
LANCET INFECT DIS. 2017;17(2):215-222.

Increased frequency of CD39+ CD56 bright Natural Killer cells in HIV-1 infection correlates with immune activation and disease progression
Dierks P, Wroblewski R, Eberhard J, Martrus G, Degen O, Hertling S, Schmiedel S, Lunemann S, Hüfner A, Lohse A, Altfeld M, van Lunzen J, Schulze Zur Wiesch J
JAIDS-J ACQ IMM DEF. 2017;74(4):467-472.

Assessment of the HIV-1 reservoir in CD4+ regulatory T cells by a Droplet Digital PCR based approach
Dunay G, Solomatina A, Kummer S, Hüfner A, Bialek J, Eberhard J, Tolosa E, Hauber J, Wiesch J
VIRUS RES. 2017;240:107-111.

Down-regulation of CD73 on B cells of patients with viremic HIV correlates with B cell activation and disease progression
Kim E, Ackermann C, Tóth I, Dierks P, Eberhard J, Wroblewski R, Scherg F, Geyer M, Schmidt R, Beisel C, Bockhorn M, Haag F, Lunzen J, Schulze Zur Wiesch J
J LEUKOCYTE BIOL. 2017;101(5):1263-1271.

Circulating CXCR5(+)CXCR3(+)PD-1(lo) Tfh-like cells in HIV-1 controllers with neutralizing antibody breadth
Martin-Gayo E, Cronin J, Hickman T, Ouyang Z, Lindqvist M, Kolb K, Schulze Zur Wiesch J, Cubas R, Porichis F, Shalek A, Lunzen J, Haddad E, Walker B, Kaufmann D, Lichterfeld M, Yu X
JCI Insight. 2017;2(2):e89574.

High clinical manifestation rate in an imported outbreak of hepatitis E genotype 1 infection in a German group of travellers returning from India
Pischke S, Schulze zur Wiesch J, Lütgehetmann M, Kreuels B, Lüth S, Kapaun P, Benten D, Schmiedel S, Sterneck M, Lohse A, Polywka S
ANN HEPATOL. 2017;16(1):57-62.

Infections complicating severe alcoholic Hepatitis: Enterococcus species represent the most frequently identified pathogen
Beisel C, Blessin U, Schulze Zur Wiesch J, Wehmeyer M, Lohse A, Benten D, Kluwe J
SCAND J GASTROENTERO. 2016;51(7):807-13.

Increased CD56(bright) NK cells in HIV-HCV co-infection and HCV mono-infection are associated with distinctive alterations of their phenotype
Bhardwaj S, Ahmad F, Wedemeyer H, Cornberg M, Schulze Zur Wiesch J, Lunzen J, Sarin S, Schmidt R, Meyer-Olson D
J VIROL. 2016;13:67.

Parallel assessment of Th17 cell frequencies by surface marker co-expression versus ex vivo IL-17 production in HIV-1 infection
Dunay G, Tóth I, Eberhard J, Degen O, Tolosa E, Lunzen J, Hauber J, Zur Wiesch J
CYTOMETRY B CLIN CYTOM. 2016;90(6):486-492.

Partial recovery of senescence and differentiation disturbances in CD8(+) T cell effector-memory cells in HIV-1 nfection after initiation of anti-retroviral treatment.
Eberhard J, Ahmad F, Hong H, Bhatnagar N, Keudel P, Schulze zur Wiesch J, Schmidt R, Meyer-Olson D
CLIN EXP IMMUNOL. 2016;186(2):227-238.

Reduced CD161(+) MAIT cell frequencies in HCV and HIV/HCV co-infection: Is the liver the heart of the matter?
Eberhard J, Kummer S, Hartjen P, Hüfner A, Diedrich T, Degen O, Lohse A, Lunzen J, Schulze Zur Wiesch J
J HEPATOL. 2016;65(6):1261-1263.

Sofosbuvir and Ledipasvir for 8 Weeks for the Treatment of Chronic Hepatitis C Virus (HCV) Infection in HCV-Monoinfected and HIV-HCV-Coinfected Individuals: Results From the German Hepatitis C Cohort (GECCO-01).
Ingiliz P, Christensen S, Kimhofer T, Hueppe D, Lutz T, Schewe K, Busch H, Schmutz G, Wehmeyer M, Boesecke C, Simon K, Berger F, Rockstroh J, Schulze zur Wiesch J, Baumgarten A, Mauss S
CLIN INFECT DIS. 2016;63(10):1320-1324.

New findings in HCV genotype distribution in selected West European, Russian and Israeli regions
Kartashev V, Döring M, Nieto L, Coletta E, Kaiser R, Sierra S
J CLIN VIROL. 2016;81:82-9.

Acute Malaria Induces PD1+CTLA4+ Effector T Cells with Cell-Extrinsic Suppressor Function
Mackroth M, Abel A, Steeg C, Schulze Zur Wiesch J, Jacobs T
PLOS PATHOG. 2016;12(11):e1005909.

Cytokine and Chemokine Signature in Elite versus Viremic Controllers infected with HIV
Platten M, Jung N, Trapp S, Floßdorf P, Meyer-Olson D, Schulze Zur Wiesch J, Stephan C, Mauss S, Weiß V, von Bergwelt-Balidon M, Rockstroh J, Fätkenheuer G, Lehmann C
AIDS RES HUM RETROV. 2016;32(6):579-87.

High proportion of HIV late presenters at an academic tertiary care center in northern Germany confirms the results of several cohorts in Germany: time to put better HIV screening efforts on the national agenda?
Schäfer G, Kreuels B, Schmiedel S, Hertling S, Hüfner A, Degen O, Lunzen J, Schulze Zur Wiesch J
INFECTION. 2016;44(3):347-52.

Breadth of the HCV-specific CD4+ T-cell response in spontaneous resolvers is independent of the IL-28 haplotype
Scheurich C, Schulze Zur Wiesch J, Kim A, Lewis-Ximenez L, Meyer T, Polywka S, Chung R, Lauer G
J VIRAL HEPATITIS. 2016;23(10):831-2.

Medizinische Versorgung von Flüchtlingen – Eine Fallserie des Universitätsklinikums Hamburg-Eppendorf
Sothmann P, Schmedt auf der Günne N, Roggelin L, Kreuels B, Rothe C, Addo M, Lohse A, Schulze zur Wiesch J, Schmiedel S
Flug-Tropen-Reisemedizin. 2016;23(1):45-49.

Nonalcoholic fatty liver disease is associated with excessive calorie intake rather than a distinctive dietary pattern
Wehmeyer M, Zyriax B, Jagemann B, Roth E, Windler E, Schulze Zur Wiesch J, Lohse A, Kluwe J
MEDICINE. 2016;95(23):e3887.

Development of a novel IGRA assay to test T cell responsiveness to HBV antigens in whole blood of chronic Hepatitis B patients
Dammermann W, Bentzien F, Stiel E, Kühne C, Ullrich S, Schulze Zur Wiesch J, Lüth S
J TRANSL MED. 2015;13(2015):Art. 157.

CRISPR/Cas9 nickase-mediated disruption of hepatitis B virus open reading frame S and X
Karimova M, Beschorner N, Dammermann W, Chemnitz J, Indenbirken D, Bockmann J, Grundhoff A, Lüth S, Buchholz F, Schulze zur Wiesch J, Hauber J
SCI REP-UK. 2015;5:13734.

Increased Frequency of CD49b/LAG-3(+) Type 1 Regulatory T Cells in HIV-Infected Individuals
Koch K, Koch N, Sandaradura de Silva U, Jung N, Schulze Zur Wiesch J, Fätkenheuer G, Hartmann P, Romerio F, Lehmann C
AIDS RES HUM RETROV. 2015;31(12):1238-46.

Low SAMHD1 expression following T-cell activation and proliferation renders CD4+ T cells susceptible to HIV-1
Ruffin N, Brezar V, Ayinde D, Lefebvre C, Schulze Zur Wiesch J, Lunzen J, Bockhorn M, Schwartz O, Hocini H, Lelievre J, Banchereau J, Levy Y, Seddiki N
AIDS. 2015;29(5):519-30.

The elephant and the blind men: making sense of the seemingly multifaceted role of Blimp-1 in HIV-1 infection
Schulze Zur Wiesch J, Beisel C
AIDS. 2015;29(1):134-6.

Efficacy and safety of sofosbuvir-based triple therapy in hepatitis C genotype 4 infection.
Wehmeyer M, Jordan S, Lüth S, Hartl J, Stoehr A, Eißing C, Lohse A, Petersen J, Buggisch P, Schulze zur Wiesch J
DIGEST LIVER DIS. 2015;47(9):811-814.

German cohort of HCV mono-infected and HCV/HIV co-infected patients reveals relative under-treatment of co-infected patients
Beisel C, Heuer M, Otto B, Jochum J, Schmiedel S, Hertling S, Degen O, Lüth S, Lunzen J, Schulze Zur Wiesch J
AIDS RES THER. 2014;11:16.

Reduced expression of Blimp-1 in memory B cells in patients with HIV-1 infection suggests distinct roles of this molecule for B and T cell regulation
Beisel C, Toth I, Lunzen J, Schulze Zur Wiesch J
AIDS. 2014;28(16):2489-2491.

CD161+ MAIT cells are severely reduced in peripheral blood and lymph nodes of HIV-infected individuals independently of disease progression
Eberhard J, Hartjen P, Kummer S, Schmidt R, Bockhorn M, Lehmann C, Balagopal A, Hauber J, Lunzen J, Schulze zur Wiesch J
PLOS ONE. 2014;9(11):e111323.

Age-related differences in response to peginterferon alfa-2a/ribavirin in patients with chronic hepatitis C infection
Roeder C, Jordan S, Schulze Zur Wiesch J, Pfeiffer-Vornkahl H, Hueppe D, Mauss S, Zehnter E, Stoll S, Alshuth U, Lohse A, Lüth S
WORLD J GASTROENTERO. 2014;20(31):10984-10993.

Leberzirrhose - Was bringen die neuen Substanzen?
Schulze zur Wiesch J, Lüth S
Hepatitis and more. 2014;1:25-28.

Safety and efficacy of protease inhibitor based combination therapy in a single-center "real-life" cohort of 110 patients with chronic hepatitis C genotype 1 infection
Wehmeyer M, Eißing F, Jordan S, Röder C, Hennigs A, Degen O, Hüfner A, Hertling S, Schmiedel S, Sterneck M, Lunzen J, Lohse A, Schulze Zur Wiesch J, Lüth S
BMC GASTROENTEROL. 2014;14:87.

Increased expression of complement regulators CD55 and CD59 on peripheral blood cells in patients with EAHEC O104:H4 infection
Dammermann W, Schipper P, Ullrich S, Zimmermann-Fraedrich K, Schulze Zur Wiesch J, Fründt T, Tiegs G, Lohse A, Lüth S
PLOS ONE. 2013;8(9):e74880.

The NTPase/helicase domain of hepatitis C virus nonstructural protein 3 inhibits protein kinase C independently of its NTPase activity
Hartjen P, Höchst B, Heim D, von der Kammer H, Lucke J, Reinholz M, Baier A, Smeets R, Wege H, Borowski P, Schulze Zur Wiesch J
CELL MOL BIOL LETT. 2013;18(3):447-58.

Vγ2Vδ2 T cells are skewed toward a terminal differentiation phenotype in untreated HIV infection
Hartjen P, Meyer-Olson D, Lehmann C, Stellbrink H, van Lunzen J, Schulze zur Wiesch J
J INFECT DIS. 2013;208(1):180-2.

Functional characterization of HLA-G⁺ regulatory T cells in HIV-1 infection
Li C, Toth I, Schulze Zur Wiesch J, Pereyra F, Rychert J, Rosenberg E, van Lunzen J, Lichterfeld M, Yu X
PLOS PATHOG. 2013;9(1):e1003140.

Improved treatment for primary HIV infection by interferon-alfa therapy? Does HCV treatment in HIV/HCV coinfected patients help us to test this hypothesis?
Schulze Zur Wiesch J, van Lunzen J
J INFECT DIS. 2013;208(2):362-363.

Decreased frequency of CD73+CD8+ T cells of HIV-infected patients correlates with immune activation and T cell exhaustion
Tóth I, Le A, Hartjen P, Thomssen A, Matzat V, Lehmann C, Scheurich C, Beisel C, Busch C, Degen O, Lohse A, Eiermann T, Fätkenheuer G, Meyer-Olson D, Bockhorn M, Hauber J, Lunzen J, Schulze Zur Wiesch J
J LEUKOCYTE BIOL. 2013;94(4):551-61.

Assessment of the range of the HIV-1 infectivity enhancing effect of individual human semen specimen and the range of inhibition by EGCG.
Hartjen P, Frerk S, Hauber I, Matzat V, Thomssen A, Holstermann B, Hohenberg H, Schulze W, Schulze Zur Wiesch J, van Lunzen J
AIDS RES THER. 2012;9(1):2.

Expansion of HIV-specific T follicular helper cells in chronic HIV infection.
Lindqvist M, van Lunzen J, Soghoian D, Kuhl B, Ranasinghe S, Kranias G, Flanders M, Cutler S, Yudanin N, Muller M, Davis I, Farber D, Hartjen P, Haag F, Alter G, Schulze Zur Wiesch J, Streeck H
J CLIN INVEST. 2012;122(9):3271-3280.

Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence.
Schulze Zur Wiesch J, Ciuffreda D, Lewis-Ximenez L, Kasprowicz V, Nolan B, Streeck H, Aneja J, Reyor L, Allen T, Lohse A, McGovern B, Chung R, Kwok W, Kim A, Lauer G
J EXP MED. 2012;209(1):61-75.

The transhepatic endotoxin gradient is present despite liver cirrhosis and is attenuated after transjugular portosystemic shunt (TIPS).
Benten D, Schulze Zur Wiesch J, Sydow K, Koops A, Buggisch P, Böger R, Gaydos C, Won H, Franco V, Lohse A, Ray S, Balagopal A
BMC GASTROENTEROL. 2011;11:107.

Spontaneous control of HCV is associated with expression of HLA-B 57 and preservation of targeted epitopes.
Kim A, Kuntzen T, Timm J, Nolan B, Baca M, Reyor L, Berical A, Feller A, Johnson K, Schulze Zur Wiesch J, Robbins G, Chung R, Walker B, Carrington M, Allen T, Lauer G
GASTROENTEROLOGY. 2011;140(2):681-686.

Real-Life comparison of pegylated-interferon 2a versus 2b combination therapy of chronic hepatitis C virus.
Schulze Zur Wiesch J, Pudelski N, Hoepner L, Supplieth M, Buggisch P, Lohse A, Lüth S
HEPATOLOGY. 2011;53(4):1405-1407.

Comprehensive analysis of frequency and phenotype of T regulatory cells in HIV infection: CD39 expression of FoxP3+ T regulatory cells correlates with progressive disease.
Schulze Zur Wiesch J, Thomssen A, Hartjen P, Toth I, Lehmann C, Meyer-Olson D, Colberg K, Frerk S, Babikir D, Schmiedel S, Degen O, Mauss S, Rockstroh J, Staszewski S, Khaykin P, Strasak A, Lohse A, Fätkenheuer G, Hauber J, van Lunzen J
J VIROL. 2011;85(3):1287-1297.

Hide and seek... Can we eradicate HIV by treatment intensification?
Schulze Zur Wiesch J, van Lunzen J
J INFECT DIS. 2011;203(7):894-897.

Antibody dynamics and spontaneous viral clearance in patients with acute hepatitis C infection in Rio de Janeiro, Brazil.
Strasak A, Kim A, Lauer G, Sousa d, Paulo S, Ginuino C, Fernandes C, Velloso C, Almeida d, Adilson J, Schulze Zur Wiesch J, Jaqueline M, Yoshida C, Julian S, Paranhos-Baccalá G, Lang S, Brant L, Ulmer H, Strohmaier S, Kaltenbach L, Lampe E, Lewis-Ximenez L
BMC INFECT DIS. 2011;11:15.

Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolution.
Kasprowicz V, Kang Y, Lucas M, Schulze Zur Wiesch J, Kuntzen T, Fleming V, Nolan B, Longworth S, Berical A, Bengsch B, Thimme R, Lewis-Ximenez L, Allen T, Kim A, Klenerman P, Lauer G
J VIROL. 2010;84(3):1656-1663.

Prospective follow-up of patients with acute hepatitis C virus infection in Brazil.
Lewis-Ximenez L, Lauer G, Schulze Zur Wiesch J, Sousa d, Fonseca P, Ginuino C, Paranhos-Baccalá G, Ulmer H, Pfeiffer K, Goebel G, Pereira J, Jaqueline M, Yoshida C, Lampe E, Velloso C, Marcelo A, Coelho H, Almeida A, Fernandes C, Kim A, Strasak A
CLIN INFECT DIS. 2010;50(9):1222-1230.

Genomic Tandem Repeat Analysis Proves Laboratory-Acquired Brucellosis in Veterinary (Camel) Diagnostic Laboratory in the United Arab Emirates.
Schulze Zur Wiesch J, Wichmann D, Sobottka I, Rohde H, Schmoock G, Wernery R, Schmiedel S, Burchard G, Melzer F
ZOONOSES PUBLIC HLTH. 2010;57(5):315-317.

Results of the IDEAL trial: "Mirror, mirror on the wall ... which's the fairest peg-interferon of them all?".
Schulze Zur Wiesch J, Lohse A
HEPATOLOGY. 2009;50(6):2034-2037.

Sustained virological response after early antiviral treatment of acute hepatitis C virus and HIV coinfection.
Schulze Zur Wiesch J, Pieper D, Stahmer I, Eiermann T, Buggisch P, Lohse A, Hauber J, van Lunzen J
CLIN INFECT DIS. 2009;49(3):466-472.

High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome.
Kasprowicz V, Schulze Zur Wiesch J, Kuntzen T, Nolan B, Longworth S, Berical A, Blum J, McMahon C, Reyor L, Elias N, Kwok W, McGovern B, Freeman G, Chung R, Klenerman P, Lewis-Ximenez L, Walker B, Allen T, Kim A, Lauer G
J VIROL. 2008;82(6):3154-3160.

Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve patients.
Kuntzen T, Timm J, Berical A, Lennon N, Berlin A, Young S, Lee B, Heckerman D, Carlson J, Reyor L, Kleyman M, McMahon C, Birch C, Schulze Zur Wiesch J, Ledlie T, Koehrsen M, Kodira C, Roberts A, Lauer G, Rosen H, Bihl F, Cerny A, Spengler U, Liu Z, Kim A, Xing Y, Schneidewind A, Madey M, Fleckenstein J, Park V, Galagan J, Nusbaum C, Walker B, Lake-Bakaar G, Daar E, Jacobson I, Gomperts E, Edlin B, Donfield S, Chung R, Talal A, Marion T, Birren B, Henn M, Allen T
HEPATOLOGY. 2008;48(6):1769-1778.

Primary HIV infection presenting as haemolytic crisis in a patient with previously undiagnosed glucose 6-phosphate dehydrogenase deficiency.
Schulze Zur Wiesch J, Wichmann D, Hennigs A, van Lunzen J, Burchard G, Schmiedel S
AIDS. 2008;22(14):1886-1888.

Viral sequence evolution in acute hepatitis C virus infection
Kuntzen T, Timm J, Berical A, Lewis-Ximenez L, Jones A, Nolan B, Schulze zur Wiesch J, Li B, Schneidewind A, Kim A, Chung R, Lauer G, Allen T
J VIROL. 2007;81(21):11658-68.

Human leukocyte antigen-associated sequence polymorphisms in hepatitis C virus reveal reproducible immune responses and constraints on viral evolution
Timm J, Li B, Daniels M, Bhattacharya T, Reyor L, Allgaier R, Kuntzen T, Fischer W, Nolan B, Duncan J, Schulze zur Wiesch J, Kim A, Frahm N, Brander C, Chung R, Lauer G, Korber B, Allen T
HEPATOLOGY. 2007;46(2):339-49.

Outcomes and treatment of acute hepatitis C virus infection in a United States population
Corey K, Ross A, Wurcel A, Schulze Zur Wiesch J, Kim A, Lauer G, Chung R
CLIN GASTROENTEROL H. 2006;4(10):1278-82.

Impaired hepatitis C virus-specific T cell responses and recurrent hepatitis C virus in HIV coinfection
Kim A, Schulze zur Wiesch J, Kuntzen T, Timm J, Kaufmann D, Duncan J, Jones A, Wurcel A, Davis B, Gandhi R, Robbins G, Allen T, Chung R, Lauer G, Walker B
PLOS MED. 2006;3(12):e492.

Acute hepatitis C virus infection in incarcerated injection drug users
McGovern B, Wurcel A, Kim A, Schulze zur Wiesch J, Bica I, Zaman M, Timm J, Walker B, Lauer G
CLIN INFECT DIS. 2006;42(12):1663-1670.

The magnitude and breadth of hepatitis C virus-specific CD8+ T cells depend on absolute CD4+ T-cell count in individuals coinfected with HIV-1
Kim A, Lauer G, Ouchi K, Addo M, Lucas M, Schulze Zur Wiesch J, Timm J, Boczanowski M, Duncan J, Wurcel A, Casson D, Chung R, Draenert R, Klenerman P, Walker B
BLOOD. 2005;105(3):1170-8.

Full-breadth analysis of CD8+ T-cell responses in acute hepatitis C virus infection and early therapy
Lauer G, Lucas M, Timm J, Ouchi K, Kim A, Day C, Schulze Zur Wiesch J, Paranhos-Baccala G, Sheridan I, Casson D, Reiser M, Gandhi R, Li B, Allen T, Chung R, Klenerman P, Walker B
J VIROL. 2005;79(20):12979-12988.

Broad repertoire of the CD4+ Th cell response in spontaneously controlled hepatitis C virus infection includes dominant and highly promiscuous epitopes
Schulze zur Wiesch J, Lauer G, Day C, Kim A, Ouchi K, Duncan J, Wurcel A, Timm J, Jones A, Mothe B, Allen T, McGovern B, Lewis-Ximenez L, Sidney J, Sette A, Chung R, Walker B
J IMMUNOL. 2005;175(6):3603-13.

CD8 epitope escape and reversion in acute HCV infection
Timm J, Lauer G, Kavanagh D, Sheridan I, Kim A, Lucas M, Pillay T, Ouchi K, Reyor L, Schulze zur Wiesch J, Gandhi R, Chung R, Bhardwaj N, Klenerman P, Walker B, Allen T
J EXP MED. 2004;200(12):1593-1604.

The proteins of the Hepatitis C Virus: their features and interactions with intracellular protein phosphorylation
Schulze zur Wiesch J, Schmitz H, Borowski E, Borowski P
ARCH VIROL. 2003;148(7):1247-67.

Inhibition of the helicase activity of HCV NTPase/helicase by 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide-5 '-triphosphate (ribavirin-TP)
Borowski P, Lang M, Niebuhr A, Haag A, Schmitz H, Schulze zur Wiesch J, Choe J, Siwecka M, Kulikowski T
ACTA BIOCHIM POL. 2001;48(3):739-44.

Biochemical properties of a minimal functional domain with ATP-binding activity of the NTPase/helicase of hepatitis C virus
Borowski P, Kuehl R, Mueller O, Hwang L, Schulze Zur Wiesch J, Schmitz H
EUR J BIOCHEM. 1999;266(3):715-23.

Identification and characterization of a histone binding site of the non-structural protein 3 of hepatitis C virus
Borowski P, Kühl R, Laufs R, Schulze zur Wiesch J, Heiland M
J CLIN VIROL. 1999;13(1-2):61-9.

Protein kinase C recognizes the protein kinase A-binding motif of nonstructural protein 3 of hepatitis C virus
Borowski P, Schulze zur Wiesch J, Resch K, Feucht H, Laufs R, Schmitz H
J BIOL CHEM. 1999;274(43):30722-8.

Letzte Aktualisierung aus dem FIS: 01.06.2020 - 06:27 Uhr