Deficiency of Complement C3a and C5a receptors Does Not Prevent Angiotensin II-Induced Hypertension and Hypertensive End-Organ Damage
Bode M, Herrnstadt G, Dreher L, Ehnert N, Kirkerup P, Lindenmeyer M, Meyer-Schwesinger C, Ehmke H, Köhl J, Huber T, Krebs C, Steinmetz O, Wiech T, Wenzel U
HYPERTENSION. 2024;81(1):138-150.

The proteasome modulates endocytosis specifically in glomerular cells to promote kidney filtration
Sachs W, Blume L, Loreth D, Schebsdat L, Hatje F, Koehler S, Wedekind U, Sachs M, Zieliniski S, Brand J, Conze C, Florea B, Heppner F, Krüger E, Rinschen M, Kretz O, Thünauer R, Meyer-Schwesinger C
NAT COMMUN. 2024;15(1):1897.

Kidney-resident innate-like memory γδ T cells control chronic Staphylococcus aureus infection of mice
Bertram T, Reimers D, Lory N, Schmidt C, Schmid J, C Heinig L, Bradtke P, Rattay G, Zielinski S, Hellmig M, Bartsch P, Rohde H, Nuñez S, Rosemblatt M, Bono M, Gagliani N, Sandrock I, Panzer U, Krebs C, Meyer-Schwesinger C, Prinz I, Mittrücker H
P NATL ACAD SCI USA. 2023;120(1):e2210490120.

Role of the deubiquitinating enzyme UCH-L1 in mitochondrial function
Bouron A, Aubry L, Loreth D, Fauvarque M, Meyer-Schwesinger C
FRONT CELL NEUROSCI. 2023;17:1149954.

Accumulation of α-synuclein mediates podocyte injury in Fabry nephropathy
Braun F, Abed A, Sellung D, Rogg M, Woidy M, Eikrem O, Wanner N, Gambardella J, Laufer S, Haas F, Wong M, Dumoulin B, Rischke P, Mühlig A, Sachs W, von Cossel K, Schulz K, Muschol N, Gersting S, Muntau A, Kretz O, Hahn O, Rinschen M, Mauer M, Bork T, Grahammer F, Liang W, Eierhoff T, Römer W, Hansen A, Meyer-Schwesinger C, Iaccarino G, Tøndel C, Marti H, Najafian B, Puelles V, Schell C, Huber T
J CLIN INVEST. 2023;133(11):.

Single-cell transcriptomics reveals a mechanosensitive injury signaling pathway in early diabetic nephropathy
Liu S, Zhao Y, Lu S, Zhang T, Lindenmeyer M, Nair V, Gies S, Wu G, Nelson R, Czogalla J, Aypek H, Zielinski S, Liao Z, Schaper M, Fermin D, Cohen C, Delic D, Krebs C, Grahammer F, Wiech T, Kretzler M, Meyer-Schwesinger C, Bonn S, Huber T
GENOME MED. 2023;15(1):2.

Transcriptional and Clonal Characterization of Cytotoxic T Cells in Crescentic Glomerulonephritis
Mueller A, Zhao Y, Cicek H, Paust H, Sivayoganathan A, Linke A, Wegscheid C, Wiech T, Huber T, Meyer-Schwesinger C, Bonn S, Prinz I, Panzer U, Tiegs G, Krebs C, Neumann K
J AM SOC NEPHROL. 2023;34(6):1003-1018.

CD4+ T cells produce GM-CSF and drive immune-mediated glomerular disease by licensing monocyte-derived cells to produce MMP12
Paust H, Song N, De Feo D, Asada N, Tuzlak S, Zhao Y, Riedel J, Hellmig M, Sivayoganathan A, Peters A, Kaffke A, Borchers A, Wenzel U, Steinmetz O, Tiegs G, Meister E, Mack M, Kurts C, von Vietinghoff S, Lindenmeyer M, Hoxha E, Stahl R, Huber T, Bonn S, Meyer-Schwesinger C, Wiech T, Turner J, Becher B, Krebs C, Panzer U
SCI TRANSL MED. 2023;15(687):.

Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis
Reichelt J, Sachs W, Frömbling S, Fehlert J, Studencka-Turski M, Betz A, Loreth D, Blume L, Witt S, Pohl S, Brand J, Czesla M, Knop J, Florea B, Zielinski S, Sachs M, Hoxha E, Hermans-Borgmeyer I, Zahner G, Wiech T, Krüger E, Meyer-Schwesinger C
NAT COMMUN. 2023;14(1):2114.

Pathogenicity of Human anti-PLA2R1 Antibodies in Minipigs: A Pilot Study
Reinhard L, Wiech T, Reitmeier A, Lassé M, Machalitza M, Heumann A, Ferru N, Loreth D, Schröder M, Hutzfeldt A, Stahl F, Peine S, Gröne H, Meyer-Schwesinger C, Rinschen M, Stahl R, Hoxha E
J AM SOC NEPHROL. 2023;34(3):369-373.

The classical pathway triggers pathogenic complement activation in membranous nephropathy
Seifert L, Zahner G, Meyer-Schwesinger C, Hickstein N, Dehde S, Wulf S, Köllner S, Lucas R, Kylies D, Froembling S, Zielinski S, Kretz O, Borodovsky A, Biniaminov S, Wang Y, Cheng H, Koch-Nolte F, Zipfel P, Hopfer H, Puelles V, Panzer U, Huber T, Wiech T, Tomas N
NAT COMMUN. 2023;14(1):473.

Podocyte expression of human phospholipase A2 receptor 1 causes immune-mediated membranous nephropathy in mice
Tomas N, Dehde S, Meyer-Schwesinger C, Huang M, Hermans-Borgmeyer I, Maybaum J, Lucas R, von der Heide J, Kretz O, Köllner S, Seifert L, Huber T, Zahner G
KIDNEY INT. 2023;103(2):297-303.

The AE4 transporter mediates kidney acid-base sensing
Vitzthum H, Koch M, Eckermann L, Svendsen S, Berg P, Hübner C, Leipziger J, Meyer-Schwesinger C, Ehmke H
NAT COMMUN. 2023;14(1):3051.

Antigen Cross-Presentation by Murine Proximal Tubular Epithelial Cells Induces Cytotoxic and Inflammatory CD8+ T Cells
Linke A, Cicek H, Müller A, Meyer-Schwesinger C, Melderis S, Wiech T, Wegscheid C, Ridder J, Steinmetz O, Diehl L, Tiegs G, Neumann K
CELLS-BASEL. 2022;11(9):.

Ectodomain shedding by ADAM proteases as a central regulator in kidney physiology and disease
Meyer-Schwesinger C, Seipold L, Saftig P
BBA-MOL CELL RES. 2022;1869(3):.

The Calcium-Sensing Receptor Stabilizes Podocyte Function in Proteinuric Humans and Mice
Mühlig A, Steingröver J, Heidelbach H, Wingerath M, Sachs W, Hermans-Borgmeyer I, Meyer-Schwesinger C, Choi H, Lim B, Patry C, Hoffmann G, Endlich N, Bracke K, Weiß M, Guse A, Lassé M, Rinschen M, Braun F, Huber T, Puelles V, Schmitt C, Oh J
KIDNEY INT. 2022;101(6):1186-1199.

Inhibition of p38 MAPK decreases hyperglycemia-induced nephrin endocytosis and attenuates albuminuria
Woznowski M, Potthoff S, Königshausen E, Haase R, Hoch H, Meyer-Schwesinger C, Wiech T, Stegbauer J, Rump L, Sellin L, Quack I
J MOL MED. 2022;100(5):781-795.

Tripartite Separation of Glomerular Cell-Types and Proteomes From Reporter-Free Mice
Hatje F, Wedekind U, Sachs W, Loreth D, Reichelt J, Demir F, Kosub C, Heintz L, Tomas N, Huber T, Skuza S, Sachs M, Zielinski S, Rinschen M, Meyer-Schwesinger C
J AM SOC NEPHROL. 2021;32(9):2175-2193.

The Intertwining of Autophagy and the Ubiquitin Proteasome System in Podocyte (Patho)Physiology
Heintz L, Meyer-Schwesinger C
CELL PHYSIOL BIOCHEM. 2021;55(S4):68-95.

ADP-Ribosylation Regulates the Signaling Function of IFN-γ
Menzel S, Koudelka T, Rissiek B, Haag F, Meyer-Schwesinger C, Tholey A, Koch-Nolte F
FRONT IMMUNOL. 2021;12:642545.

Lysosome function in glomerular health and disease
Meyer-Schwesinger C
CELL TISSUE RES. 2021;385(2):371-392.

ADAM10-Mediated Ectodomain Shedding Is an Essential Driver of Podocyte Damage
Sachs M, Wetzel S, Reichelt J, Sachs W, Schebsdat L, Zielinski S, Seipold L, Heintz L, Müller S, Kretz O, Lindenmeyer M, Wiech T, Huber T, Lüllmann-Rauch R, Lichtenthaler S, Saftig P, Meyer-Schwesinger C
J AM SOC NEPHROL. 2021;32(6):1389-1408.

CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression
Schneider E, Winzer R, Rissiek A, Ricklefs I, Meyer-Schwesinger C, Ricklefs F, Bauche A, Behrends J, Reimer R, Brenna S, Wasielewski H, Lauten M, Rissiek B, Puig B, Cortesi F, Magnus T, Fliegert R, Müller C, Gagliani N, Tolosa E
NAT COMMUN. 2021;12(1):5911.

Enzyme replacement therapy in mice lacking arylsulfatase B targets bone remodeling cells, but not chondrocytes
Hendrickx G, Danyukova T, Baranowsky A, Rolvien T, Angermann A, Schweizer M, Keller J, Schröder J, Meyer-Schwesinger C, Muschol N, Paganini C, Rossi A, Amling M, Pohl S, Schinke T
HUM MOL GENET. 2020;29(5):803-816.

Pathogen-induced tissue-resident memory TH17 (TRM17) cells amplify autoimmune kidney disease
Krebs C, Reimers D, Zhao Y, Paust H, Bartsch P, Nuñez S, Rosemblatt M, Hellmig M, Kilian C, Borchers A, Enk L, Zinke M, Becker M, Schmid J, Klinge S, Wong M, Puelles V, Schmidt C, Bertram T, Stumpf N, Hoxha E, Meyer-Schwesinger C, Lindenmeyer M, Cohen C, Rink M, Kurts C, Franzenburg S, Koch-Nolte F, Turner J, Riedel J, Huber S, Gagliani N, Huber T, Wiech T, Rohde H, Bono M, Bonn S, Panzer U, Mittrücker H
SCI IMMUNOL. 2020;5(50):.

The ins-and-outs of podocyte lipid metabolism
Meyer-Schwesinger C
KIDNEY INT. 2020;98(5):1087-1090.

Glomerular Cell Biology and Podocytopathies
Meyer-Schwesinger C, Huber T
2020. Brenner + Rector's The Kidney. Yu A (eds.). 11. ed. USA, Philadelphia: Elsevier Inc., 115-132.

A novel mouse model of phospholipase A2 receptor 1-associated membranous nephropathy mimics podocyte injury in patients
Meyer-Schwesinger C, Tomas N, Dehde S, Seifert L, Hermans-Borgmeyer I, Wiech T, Koch-Nolte F, Huber T, Zahner G
KIDNEY INT. 2020;97(5):913-919.

Inhibition of mTOR delayed but could not prevent experimental collapsing focal segmental glomerulosclerosis
Miesen L, Eymael J, Sharma S, Loeven M, Willemsen B, Bakker-van Bebber M, Mooren F, Meyer-Schwesinger C, Dijkman H, Wetzels J, Jansen J, van der Vlag J, Smeets B
SCI REP-UK. 2020;10(1):8580.

Podocytes Produce and Secrete Functional Complement C3 and Complement Factor H
Mühlig A, Keir L, Abt J, Heidelbach H, Horton R, Welsh G, Meyer-Schwesinger C, Licht C, Coward R, Fester L, Saleem M, Oh J
FRONT IMMUNOL. 2020;11:1833.

Distinct modes of balancing glomerular cell proteostasis in mucolipidosis type II and III prevent proteinuria
Sachs W, Sachs M, Krüger E, Zielinski S, Kretz O, Huber T, Baranowsky A, Westermann L, Voltolini Velho R, Floriano Ludwig N, Yorgan T, Di Lorenzo G, Kollmann K, Braulke T, Schwartz I, Schinke T, Danyukova T, Pohl S, Meyer-Schwesinger C
J AM SOC NEPHROL. 2020;31(8):1796-1814.

B6.Rag1 Knockout Mice Generated at the Jackson Laboratory in 2009 Show a Robust Wild-Type Hypertensive Phenotype in Response to Ang II (Angiotensin II)
Seniuk A, Thiele J, Stubbe A, Oser P, Rosendahl A, Bode M, Meyer-Schwesinger C, Wenzel U, Ehmke H
HYPERTENSION. 2020;75(4):1110-1116.

Interleukin-9 protects from early podocyte injury and progressive glomerulosclerosis in Adriamycin-induced nephropathy
Xiong T, Attar M, Gnirck A, Wunderlich M, Becker M, Rickassel C, Puelles V, Meyer-Schwesinger C, Wiech T, Nies J, Divivier M, Fuchs T, Schulze Zur Wiesch J, Taipaleenmäki H, Hoxha E, Wirtz S, Huber T, Panzer U, Turner J
KIDNEY INT. 2020;98(3):615-629.

Renal proximal tubular epithelial cells exert immunomodulatory function by driving inflammatory CD4+ T cell responses
Breda P, Wiech T, Meyer-Schwesinger C, Grahammer F, Huber T, Panzer U, Tiegs G, Neumann K
AM J PHYSIOL-RENAL. 2019;317(1):F77-F89.

Endogenous IL-22 is dispensable for experimental glomerulonephritis
Gnirck A, Wunderlich M, Becker M, Xiong T, Weinert E, Meyer-Schwesinger C, Dumoutier L, Renauld J, Huber S, Panzer U, Turner J
AM J PHYSIOL-RENAL. 2019;316(4):F712-F722.

Thrombospondin Type 1 Domain-Containing 7A Localizes to the Slit Diaphragm and Stabilizes Membrane Dynamics of Fully Differentiated Podocytes
Herwig J, Skuza S, Sachs W, Sachs M, Failla A, Rune G, Meyer T, Fester L, Meyer-Schwesinger C
J AM SOC NEPHROL. 2019;30(5):824-839.

Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins
Königshausen E, Potthoff S, Haase R, Meyer-Schwesinger C, Kaufmann E, Rump L, Stegbauer J, Sellin L, Quack I, Woznowski M
JOVE-J VIS EXP. 2019;(143):.

Protecting the kidney against autoimmunity and inflammation
Kurts C, Meyer-Schwesinger C
NAT REV NEPHROL. 2019;15(2):66-68.

An unexpected role of steroid on podocytes: from zebrafish to human nephrotic syndrome?
Meyer-Schwesinger C
KIDNEY INT. 2019;95(5):1015-1017.

The ubiquitin-proteasome system in kidney physiology and disease
Meyer-Schwesinger C
NAT REV NEPHROL. 2019;15(7):393-411.

Ubiquitin C-terminal hydrolase L1 (UCH-L1) loss causes neurodegeneration by altering protein turnover in the first postnatal weeks
Reinicke A, Laban K, Sachs M, Kraus V, Walden M, Damme M, Sachs W, Reichelt J, Schweizer M, Janiesch P, Duncan K, Saftig P, Rinschen M, Morellini F, Meyer-Schwesinger C
P NATL ACAD SCI USA. 2019;116(16):7963-7972.

Deubiquitinating Enzyme UCH-L1 Promotes Dendritic Cell Antigen Cross-Presentation by Favoring Recycling of MHC Class I Molecules
Reinicke A, Raczkowski F, Mühlig M, Schmucker P, Lischke T, Reichelt J, Schneider E, Zielinski S, Sachs M, Jurack E, Tolosa E, Kurts C, Mittrücker H, Meyer-Schwesinger C
J IMMUNOL. 2019;203(7):1730-1742.

The chemokine receptor CX3CR1 reduces renal injury in mice with angiotensin II induced hypertension
Ahadzadeh E, Rosendahl A, Czesla D, Steffens P, Prüßner L, Meyer-Schwesinger C, Wanner N, Paust H, Huber T, Stahl R, Wiech T, Kurts C, Seniuk A, Ehmke H, Wenzel U
AM J PHYSIOL-RENAL. 2018;315(6):F1526-F1535.

Glomerular endothelial cell maturation depends on ADAM10, a key regulator of Notch signaling
Farber G, Hurtado R, Loh S, Monette S, Mtui J, Kopan R, Quaggin S, Meyer-Schwesinger C, Herzlinger D, Scott R, Blobel C
ANGIOGENESIS. 2018;21(2):335-347.

Role of Apolipoprotein L1 in Human Parietal Epithelial Cell Transition
Kumar V, Vashistha H, Lan X, Chandel N, Ayasolla K, Shoshtari S, Aslam R, Paliwal N, Abbruscato F, Mikulak J, Popik W, Atta M, Chander P, Malhotra A, Meyer-Schwesinger C, Skorecki K, Singhal P
AM J PATHOL. 2018;188(11):2508-2528.

Ubiquitin C-Terminal Hydrolase L1 is required for regulated protein degradation through the ubiquitin proteasome system in kidney
Radón V, Czesla M, Reichelt J, Fehlert J, Hammel A, Rosendahl A, Knop J, Wiech T, Wenzel U, Sachs M, Reinicke A, Stahl R, Meyer-Schwesinger C
KIDNEY INT. 2018;93(1):110-127.

Disease-Linked Glutarylation Impairs Function and Interactions of Mitochondrial Proteins and Contributes to Mitochondrial Heterogeneity
Schmiesing J, Storch S, Dörfler A, Schweizer M, Makrypidi-Fraune G, Thelen M, Sylvester M, Gieselmann V, Meyer-Schwesinger C, Koch-Nolte F, Tidow H, Mühlhausen C, Waheed A, Sly W, Braulke T
CELL REP. 2018;24(11):2946-2956.

A novel in vivo method to quantify slit diaphragm protein abundance in murine proteinuric kidney disease
Haase R, Potthoff S, Meyer-Schwesinger C, Frosch C, Wiech T, Panzer U, Königshausen E, Stegbauer J, Sellin L, Rump L, Quack I, Woznowski M
PLOS ONE. 2017;12(6):e0179217.

An Indirect Immunofluorescence Method Facilitates Detection of Thrombospondin Type 1 Domain-Containing 7A-Specific Antibodies in Membranous Nephropathy
Hoxha E, Beck L, Wiech T, Tomas N, Probst C, Mindorf S, Meyer-Schwesinger C, Zahner G, Stahl P, Schöpper R, Panzer U, Harendza S, Helmchen U, Salant D, Stahl R
J AM SOC NEPHROL. 2017;28(2):520-531.

IL-33-Mediated Expansion of Type 2 Innate Lymphoid Cells Protects from Progressive Glomerulosclerosis
Riedel J, Becker M, Kopp K, Düster M, Brix S, Meyer-Schwesinger C, Kluth L, Gnirck A, Attar M, Krohn S, Fehse B, Stahl R, Panzer U, Turner J
J AM SOC NEPHROL. 2017;28(7):2068-2080.

A Heterologous Model of Thrombospondin Type 1 Domain-Containing 7A-Associated Membranous Nephropathy
Tomas N, Meyer-Schwesinger C, von Spiegel H, Kotb A, Zahner G, Hoxha E, Helmchen U, Endlich N, Koch-Nolte F, Stahl R
J AM SOC NEPHROL. 2017;28(11):3262-3277.

ISN Nexus 2016 Symposia: Translational Immunology in Kidney Disease—The Berlin Roadmap
Anders H, Rovin B, Jayne D, Brunetta P, Coppo R, Davidson A, Devarapu S, de Zeeuw D, Duffield J, Eulberg D, Fierro A, Floege J, Frese S, Guillevin L, Holdsworth S, Hughes J, Kettritz R, Kluger M, Krebs C, Lapteva L, Levin A, Li J, Lightstone L, Mack M, Mansouri L, McAdoo S, McKinney E, Panzer U, Parikh S, Pusey C, Putterman C, Rabelink T, Radbruch A, Rees A, Reilly M, Reinders M, Remuzzi G, Ruggenenti P, Sacks S, Schall T, Meyer-Schwesinger C, Sharma K, Suzuki Y, Tomas N, Zhao M
KIDNEY INT REP. 2016;1(4):327-339.

Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation
Danquah W, Meyer-Schwesinger C, Rissiek B, Pinto C, Serracant-Prat A, Amadi M, Iacenda D, Knop J, Hammel A, Bergmann P, Schwarz N, Assunção J, Rotthier W, Haag F, Tolosa E, Bannas P, Boué-Grabot E, Magnus T, Laeremans T, Stortelers C, Nolte F
SCI TRANSL MED. 2016;8(366):366ra162.

Immune Complex-Type Deposits in the Fischer-344 to Lewis Rat Model of Renal Transplantation and a Subset of Human Transplant Glomerulopathy
Grau V, Zeuschner P, Immenschuh S, Bockmeyer C, Zell S, Wittig J, Säuberlich K, Abbas M, Padberg W, Meyer-Schwesinger C, von Brandenstein M, Schlosser M, Dieplinger G, Galliford J, Clarke C, Roufosse C, Becker J
TRANSPLANTATION. 2016;100(5):1004-14.

A Mechanism for Cancer-Associated Membranous Nephropathy
Hoxha E, Wiech T, Stahl P, Zahner G, Tomas N, Meyer-Schwesinger C, Wenzel U, Janneck M, Steinmetz O, Panzer U, Harendza S, Stahl R
NEW ENGL J MED. 2016;374(20):1995-6.

Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus
Kluger M, Melderis S, Nosko A, Goerke B, Luig M, Meyer M, Turner J, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Stahl R, Panzer U, Steinmetz O
KIDNEY INT. 2016;89(1):158-166.

Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney
Krebs C, Paust H, Krohn S, Koyro T, Brix S, Riedel J, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch C, Mittrücker H, Steinhoff U, Stockinger B, Perez L, Wenzel U, Janneck M, Steinmetz O, Gagliani N, Stahl R, Huber S, Turner J, Panzer U
IMMUNITY. 2016;45(5):1078-1092.

The Role of Renal Progenitors in Renal Regeneration
Meyer-Schwesinger C
NEPHRON. 2016;132(2):101-109.

CXCR3+ Regulatory T Cells Control TH1 Responses in Crescentic GN
Paust H, Riedel J, Krebs C, Turner J, Brix S, Krohn S, Velden J, Wiech T, Kaffke A, Peters A, Bennstein S, Kapffer S, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Thaiss F, Mittrücker H, Steinmetz O, Stahl R, Panzer U
J AM SOC NEPHROL. 2016;27(7):1933-42.

Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy
Tomas N, Hoxha E, Reinicke A, Fester L, Helmchen U, Gerth J, Bachmann F, Budde K, Nolte F, Zahner G, Rune G, Lambeau G, Meyer-Schwesinger C, Stahl R
J CLIN INVEST. 2016;126(7):2519-32.

The complement receptor C5aR1 contributes to renal damage but protects the heart in angiotensin II-induced hypertension
Weiss S, Rosendahl A, Czesla D, Meyer-Schwesinger C, Stahl R, Ehmke H, Kurts C, Zipfel P, Köhl J, Wenzel U
AM J PHYSIOL-RENAL. 2016;310(11):F1356-65.

CXCL5 drives neutrophil recruitment in TH17-mediated GN
Disteldorf E, Krebs C, Paust H, Turner J, Nouailles G, Tittel A, Meyer-Schwesinger C, Stege G, Brix S, Velden J, Wiech T, Helmchen U, Steinmetz O, Peters A, Bennstein S, Kaffke A, Llanto C, Lira S, Mittrücker H, Stahl R, Kurts C, Kaufmann S, Panzer U
J AM SOC NEPHROL. 2015;26(1):55-66.

Glomerulopathy Induced by Immunization with a Peptide Derived from the Goodpasture Antigen α3IV-NC1
Hopfer H, Hünemörder S, Treder J, Turner J, Paust H, Meyer-Schwesinger C, Hopfer U, Sachs M, Peters A, Bucher-Kocaoglu B, Ahrens S, Panzer U, Mittrücker H
J IMMUNOL. 2015;194(8):3646-55.

TH1 and TH17 cells promote crescent formation in experimental autoimmune glomerulonephritis
Hünemörder S, Treder J, Ahrens S, Schumacher V, Paust H, Menter T, Matthys P, Kamradt T, Meyer-Schwesinger C, Panzer U, Hopfer H, Mittrücker H
J PATHOL. 2015;237(1):62-71.

MicroRNA-193a Regulates the Transdifferentiation of Human Parietal Epithelial Cells toward a Podocyte Phenotype
Kietzmann L, Guhr S, Meyer T, Ni L, Sachs M, Panzer U, Stahl R, Saleem M, Kerjaschki D, Gebeshuber C, Meyer-Schwesinger C
J AM SOC NEPHROL. 2015;26(6):1389-1401.

Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy REPLY
Meyer-Schwesinger C, Lambeau G, Stahl R
NEW ENGL J MED. 2015;372(11):1074-1075.

CD38 is expressed on inflammatory cells of the intestine and promotes intestinal inflammation
Schneider M, Schumacher V, Lischke T, Lücke K, Meyer-Schwesinger C, Velden J, Nolte F, Mittrücker H
PLOS ONE. 2015;10(5):e0126007.

Alterations in the Ubiquitin Proteasome System in Persistent but Not Reversible Proteinuric Diseases
Beeken M, Lindenmeyer M, Blattner S, Radón V, Oh J, Meyer T, Hildebrand D, Schlüter H, Reinicke-Vogt A, Knop J, Vivekanandan-Giri A, Münster S, Sachs M, Wiech T, Pennathur S, Cohen C, Kretzler M, Stahl R, Meyer-Schwesinger C
J AM SOC NEPHROL. 2014;25(11):2511-25.

B-cell-derived IL-10 does not vitally contribute to the clinical course of glomerulonephritis
Kluger M, Ostmann A, Luig M, Meyer M, Goerke B, Paust H, Meyer-Schwesinger C, Stahl R, Panzer U, Tiegs G, Steinmetz O
EUR J IMMUNOL. 2014;44(3):683-693.

Deficiency of the interleukin 17/23 axis accelerates renal injury in mice with deoxycorticosterone acetate+angiotensin ii-induced hypertension
Krebs C, Lange S, Niemann G, Rosendahl A, Lehners A, Meyer-Schwesinger C, Stahl R, Benndorf R, Velden J, Paust H, Panzer U, Ehmke H, Wenzel U
HYPERTENSION. 2014;63(3):565-71.

Myeloperoxidase deficiency ameliorates progression of chronic kidney disease in mice
Lehners A, Lange S, Niemann G, Rosendahl A, Meyer-Schwesinger C, Oh J, Stahl R, Ehmke H, Benndorf R, Klinke A, Baldus S, Wenzel U
AM J PHYSIOL-RENAL. 2014;307(4):F407-17.

UCH-L1 induces podocyte hypertrophy in membranous nephropathy by protein accumulation
Lohmann F, Sachs M, Meyer T, Sievert H, Lindenmeyer M, Wiech T, Cohen C, Balabanov S, Stahl R, Meyer-Schwesinger C
BBA-MOL BASIS DIS. 2014;1842(7):945-58.

CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis
Nouailles G, Dorhoi A, Koch M, Zerrahn J, Weiner J, Faé K, Arrey F, Kuhlmann S, Bandermann S, Loewe D, Mollenkopf H, Vogelzang A, Meyer-Schwesinger C, Mittrücker H, McEwen G, Kaufmann S
J CLIN INVEST. 2014;124(3):1268-82.

Crosstalk between sentinel and helper macrophages permits neutrophil migration into infected uroepithelium
Schiwon M, Weisheit C, Franken L, Gutweiler S, Dixit A, Meyer-Schwesinger C, Pohl J, Maurice N, Thiebes S, Lorenz K, Quast T, Fuhrmann M, Baumgarten G, Lohse M, Opdenakker G, Bernhagen J, Bucala R, Panzer U, Kolanus W, Gröne H, Garbi N, Kastenmüller W, Knolle P, Kurts C, Engel D
CELL. 2014;156(3):456-468.

Thrombospondin Type-1 Domain-Containing 7A in Idiopathic Membranous Nephropathy
Tomas N, Beck L, Meyer-Schwesinger C, Seitz-Polski B, Ma H, Zahner G, Dolla G, Hoxha E, Helmchen U, Dabert-Gay A, Debayle D, Merchant M, Klein J, Salant D, Stahl R, Lambeau G
NEW ENGL J MED. 2014;371(24):2277-2287.

Mouse models of membranous nephropathy: the road less travelled by
Borza D, Zhang J, Beck L, Meyer-Schwesinger C, Luo W
AM J CLIN EXP IMMUNO. 2013;2(2):135-45.

The expression of podocyte-specific proteins in parietal epithelial cells is regulated by protein degradation
Guhr S, Sachs M, Wegner A, Becker J, Meyer T, Kietzmann L, Schlossarek S, Carrier L, Balabanov M, Jat P, Stahl R, Meyer-Schwesinger C
KIDNEY INT. 2013;84(3):532-44.

MicroRNA-155 drives TH17 immune response and tissue injury in experimental crescentic GN
Krebs C, Kapffer S, Paust H, Schmidt T, Bennstein S, Peters A, Stege G, Brix S, Meyer-Schwesinger C, Müller R, Turner J, Steinmetz O, Wolf G, Stahl R, Panzer U
J AM SOC NEPHROL. 2013;24(12):1955-65.

Prognostic relevance of ubiquitin C-terminal hydrolase L1 (UCH-L1) mRNA and protein expression in breast cancer patients
Schröder C, Milde-Langosch K, Gebauer F, Schmid K, Müller V, Wirtz R, Meyer-Schwesinger C, Schluter H, Sauter G, Schumacher U
J CANCER RES CLIN. 2013;139:1745-1755.

The proteases HtrA2/Omi and UCH-L1 regulate TNF-induced necroptosis
Sosna J, Voigt S, Mathieu S, Kabelitz D, Trad A, Janssen O, Meyer-Schwesinger C, Schütze S, Adam D
CELL COMMUN SIGNAL. 2013;11:76.

Acute renal proximal tubule alterations during induced metabolic crises in a mouse model of glutaric aciduria type 1
Thies B, Meyer-Schwesinger C, Lamp J, Schweizer M, Koeller D, Ullrich K, Braulke T, Mühlhausen C
BBA-MOL BASIS DIS. 2013;1832(10):1463-72.

Characterization of the renal CD4(+) T-cell response in experimental autoimmune glomerulonephritis.
Hopfer H, Holzer J, Hünemörder S, Paust H, Sachs M, Meyer-Schwesinger C, Turner J, Panzer U, Mittrücker H
KIDNEY INT. 2012;82(1):60-71.

Rho-kinase inhibition prevents proteinuria in immune-complex-mediated antipodocyte nephritis
Meyer-Schwesinger C, Dehde S, Sachs M, Mathey S, Arefi K, Gatzemeier S, Balabanov S, Becker J, Thaiss F, Meyer T
AM J PHYSIOL-RENAL. 2012;303(7):F1015-25.

IL-17A production by renal γδ T cells promotes kidney injury in crescentic GN.
Turner J, Krebs C, Tittel A, Paust H, Meyer-Schwesinger C, Bennstein S, Steinmetz O, Prinz I, Magnus T, Korn T, Stahl R, Kurts C, Panzer U
J AM SOC NEPHROL. 2012;23(9):1486-1495.

Nephrotic syndrome and subepithelial deposits in a mouse model of immune-mediated anti-podocyte glomerulonephritis.
Meyer-Schwesinger C, Dehde S, Klug P, Becker J, Mathey S, Arefi K, Balabanov S, Venz S, Endlich K, Pekna M, Gessner J, Thaiss F, Meyer T
J IMMUNOL. 2011;187(6):3218-3229.

Bone marrow-derived progenitor cells do not contribute to podocyte turnover in the puromycin aminoglycoside and renal ablation models in rats.
Meyer-Schwesinger C, Lange C, Bröcker V, Agustian P, Putri A, Lehmann U, Raabe A, Brinkmeyer M, Kobayashi E, Schiffer M, Büsche G, Kreipe H, Thaiss F, Becker J
AM J PATHOL. 2011;178(2):494-499.

Ubiquitin C-terminal hydrolase-l1 activity induces polyubiquitin accumulation in podocytes and increases proteinuria in rat membranous nephropathy.
Meyer-Schwesinger C, Meyer T, Sievert H, Hoxha E, Sachs M, Klupp E, Münster S, Balabanov S, Carrier L, Helmchen U, Thaiss F, Stahl R
AM J PATHOL. 2011;178(5):2044-2057.

Ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) is a potential tumour suppressor in prostate cancer and is frequently silenced by promoter methylation.
Ummanni R, Jost E, Balabanov M, Lohmann F, Mundt F, Barett C, Schlomm T, Sauter G, Senff T, Bokemeyer C, Sültmann H, Meyer-Schwesinger C, Brümmendorf T, Balabanov S
MOL CANCER. 2011;10:129.

Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice.
Hartleben B, Gödel M, Meyer-Schwesinger C, Liu S, Ulrich T, Köbler S, Wiech T, Grahammer F, Arnold S, Lindenmeyer M, Cohen C, Pavenstädt H, Kerjaschki D, Mizushima N, Shaw A, Walz G, Huber T
J CLIN INVEST. 2010;120(4):1084-1096.

CIN85/RukL is a novel binding partner of nephrin and podocin and mediates slit diaphragm turnover in podocytes.
Tossidou I, Teng B, Drobot L, Meyer-Schwesinger C, Worthmann K, Haller H, Schiffer M
J BIOL CHEM. 2010;285(33):25285-25295.

Angiotensin II type 2 receptor deficiency aggravates renal injury and reduces survival in chronic kidney disease in mice.
Benndorf R, Krebs C, Hirsch-Hoffmann B, Schwedhelm E, Cieslar G, Schmidt-Haupt R, Steinmetz O, Meyer-Schwesinger C, Thaiss F, Haddad M, Fehr S, Heilmann A, Helmchen U, Hein L, Ehmke H, Stahl R, Böger R, Wenzel U
KIDNEY INT. 2009;75(10):1039-1049.

Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury.
Heymann F, Meyer-Schwesinger C, Hamilton-Williams E, Hammerich L, Panzer U, Kaden S, Quaggin S, Floege J, Gröne H, Kurts C
J CLIN INVEST. 2009;119(5):1286-1297.

Lack of type VIII collagen in mice ameliorates diabetic nephropathy.
Hopfer U, Hopfer H, Meyer-Schwesinger C, Loeffler I, Fukai N, Olsen B, Stahl R, Wolf G
DIABETES. 2009;58(7):1672-1681.

Rho kinase inhibition attenuates LPS-induced renal failure in mice in part by attenuation of NF-kappaB p65 signaling.
Meyer-Schwesinger C, Silke D, von Ruffer C, Gatzemeier S, Klug P, Wenzel U, Stahl R, Thaiss F, Meyer T
AM J PHYSIOL-RENAL. 2009;296(5):1088-1099.

Resolution of renal inflammation: a new role for NF-kappaB1 (p50) in inflammatory kidney diseases.
Panzer U, Steinmetz O, Turner J, Meyer-Schwesinger C, von Ruffer C, Meyer T, Zahner G, Gómez-Guerrero C, Schmid R, Helmchen U, Moeckel G, Wolf G, Stahl R, Thaiss F
AM J PHYSIOL-RENAL. 2009.

Alterations of the podocyte proteome in response to high glucose concentrations.
Schordan S, Schordan E, Endlich N, Lindenmeyer M, Meyer-Schwesinger C, Meyer T, Giebel J, Cohen C, Endlich K, Maurer M
PROTEOMICS. 2009;9(19):4519-4528.

The instructive role of metanephric mesenchyme in ureteric bud patterning, sculpting, and maturation and its potential ability to buffer ureteric bud branching defects.
Shah M, Tee J, Meyer T, Meyer-Schwesinger C, Choi Y, Sweeney D, Gallegos T, Johkura K, Rosines E, Kouznetsova V, Rose D, Bush K, Sakurai H, Nigam S
AM J PHYSIOL-RENAL. 2009;297(5):1330-1341.

CXCR3 mediates renal Th1 and Th17 immune response in murine lupus nephritis.
Steinmetz O, Turner J, Paust H, Lindner M, Peters A, Heiss K, Velden J, Hopfer H, Fehr S, Krieger T, Meyer-Schwesinger C, Meyer T, Helmchen U, Mittrücker H, Stahl R, Panzer U
J IMMUNOL. 2009;183(7):4693-4704.

Rapid development of severe end-organ damage in C57BL/6 mice by combining DOCA salt and angiotensin II.
Kirchhoff F, Krebs C, Abdulhag U, Meyer-Schwesinger C, Maas R, Helmchen U, Hilgers K, Wolf G, Stahl R, Wenzel U
KIDNEY INT. 2008;73(5):643-650.

Effect of (pro)renin receptor inhibition by a decoy peptide on renal damage in the clipped kidney of Goldblatt rats.
Krebs C, Weber M, Steinmetz O, Meyer-Schwesinger C, Stahl R, Danser A, Garrelds I, van Goor H, Nguyen G, Müller D, Wenzel U
KIDNEY INT. 2008;74(6):823-824.

A new role for the neuronal ubiquitin C-terminal hydrolase-L1 (UCH-L1) in podocyte process formation and podocyte injury in human glomerulopathies.
Meyer-Schwesinger C, Meyer T, Münster S, Klug P, Saleem M, Helmchen U, Stahl R
J PATHOL. 2008.

CCR5 deficiency aggravates crescentic glomerulonephritis in mice.
Turner J, Paust H, Steinmetz O, Peters A, Meyer-Schwesinger C, Heymann F, Helmchen U, Fehr S, Horuk R, Wenzel U, Kurts C, Mittrücker H, Stahl R, Panzer U
J IMMUNOL. 2008;181(9):6546-6556.

Antihypertensive therapy upregulates renin and (pro)renin receptor in the clipped kidney of Goldblatt hypertensive rats.
Krebs C, Hamming I, Sadaghiani S, Steinmetz O, Meyer-Schwesinger C, Fehr S, Stahl R, Garrelds I, Danser A, van Goor H, Contrepas A, Nguyen G, Wenzel U
KIDNEY INT. 2007;72(6):725-730.

Chemokine receptor CXCR3 mediates T cell recruitment and tissue injury in nephrotoxic nephritis in mice.
Panzer U, Steinmetz O, Paust H, Meyer-Schwesinger C, Peters A, Turner J, Zahner G, Heymann F, Kurts C, Hopfer H, Helmchen U, Haag F, Schneider A, Stahl R
J AM SOC NEPHROL. 2007;18(7):2071-2084.

A pitfall of glomerular sieving: profibrotic and matrix proteins derive from the Bowman's capsule and not the glomerular tuft in rats with renovascular hypertension.
Steinmetz O, Panzer U, Fehr S, Meyer-Schwesinger C, Stahl R, Wenzel U
NEPHROL DIAL TRANSPL. 2007;22(10):3055-3060.

Antihypertensive therapy induces compartment-specific chemokine expression and a Th1 immune response in the clipped kidney of Goldblatt hypertensive rats.
Steinmetz O, Sadaghiani S, Panzer U, Krebs C, Meyer-Schwesinger C, Streichert T, Fehr S, Hamming I, van Goor H, Stahl R, Wenzel U
AM J PHYSIOL-RENAL. 2007;292(2):876-887.

Rho kinase acts at separate steps in ureteric bud and metanephric mesenchyme morphogenesis during kidney development
Meyer T, Meyer-Schwesinger C, Sampogna R, Vaughn D, Stuart R, Steer D, Bush K, Nigam S
DIFFERENTIATION. 2006;74(9-10):638-47.

Tankyrase recruitment to the lateral membrane in polarized epithelial cells: regulation by cell-cell contact and protein poly(ADP-ribosyl)ation.
Yeh T, Meyer T, Meyer-Schwesinger C, Tsun Z, Lee R, Chi N
BIOCHEM J. 2006;399(3):415-425.

TGF-beta superfamily members modulate growth, branching, shaping, and patterning of the ureteric bud
Bush K, Sakurai H, Steer D, Leonard M, Sampogna R, Meyer T, Meyer-Schwesinger C, Qiao J, Nigam S
DEV BIOL. 2004;266(2):285-98.

Spatiotemporal regulation of morphogenetic molecules during in vitro branching of the isolated ureteric bud: toward a model of branching through budding in the developing kidney
Meyer T, Meyer-Schwesinger C, Bush K, Stuart R, Rose D, Shah M, Vaughn D, Steer D, Nigam S
DEV BIOL. 2004;275(1):44-67.

Regulation of ureteric bud branching morphogenesis by sulfated proteoglycans in the developing kidney
Steer D, Shah M, Bush K, Stuart R, Sampogna R, Meyer T, Meyer-Schwesinger C, Bai X, Esko J, Nigam S
DEV BIOL. 2004;272(2):310-27.

Galpha12 regulates epithelial cell junctions through Src tyrosine kinases
Meyer T, Hunt J, Meyer-Schwesinger C, Denker B
AM J PHYSIOL-CELL PH. 2003;285(5):C1281-93.

Zonula occludens-1 is a scaffolding protein for signaling molecules. Galpha(12) directly binds to the Src homology 3 domain and regulates paracellular permeability in epithelial cells
Meyer T, Meyer-Schwesinger C, Denker B
J BIOL CHEM. 2002;277(28):24855-8.

A strategy for in vitro propagation of rat nephrons
Steer D, Bush K, Meyer T, Meyer-Schwesinger C, Nigam S
KIDNEY INT. 2002;62(6):1958-65.

Angiogenic potential of prostate carcinoma cells overexpressing bcl-2
Fernandez A, Udagawa T, Meyer-Schwesinger C, Beecken W, Achilles-Gerte E, McDonnell T, D'Amato R
JNCI-J NATL CANCER I. 2001;93(3):208-13.

Intrachoroidal neovascularization in transgenic mice overexpressing vascular endothelial growth factor in the retinal pigment epithelium
Meyer-Schwesinger C, Yee C, Rohan R, Joussen A, Fernandez A, Meyer T, Poulaki V, Ma J, Redmond T, Liu S, Adamis A, D'Amato R
AM J PATHOL. 2001;158(3):1161-72.

Reassembly of the tight junction after oxidative stress depends on tyrosine kinase activity
Meyer T, Meyer-Schwesinger C, Ye J, Denker B, Nigam S
J BIOL CHEM. 2001;276(25):22048-55.

Letzte Aktualisierung aus dem FIS: 19.04.2024 - 06:41 Uhr