Tobias Lange
Prof. Dr. med.
Tobias Lange
PhD
  • Research fellow
  • Medical Specialist in Anatomy
Working area

Location

N62 , Ground Floor, Room number 1
Languages
German (Mother tongue)
English

Areas of expertise

Publications

Zurück
  • 2024
  • 2023
  • 2022
  • 2021
  • 2020
  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • 2011
  • 2009
  • 2008
Vor

Microplastics role in cell migration and distribution during cancer cell division
Brynzak-Schreiber E, Schögl E, Bapp C, Cseh K, Kopatz V, Jakupec M, Weber A, Lange T, Toca-Herrera J, Del Favero G, Wadsak W, Kenner L, Pichler V
CHEMOSPHERE. 2024 [Epub ahead of print];353:141463.

Spontaneous metastasis xenograft models link CD44 isoform 4 to angiogenesis, hypoxia, EMT and mitochondria-related pathways in colorectal cancer
Everest-Dass A, Nersisyan S, Maar H, Novosad V, Schröder-Schwarz J, Freytag V, Stuke J, Beine M, Schiecke A, Haider M, Kriegs M, Elakad O, Bohnenberger H, Conradi L, Raygorodskaya M, Krause L, von Itzstein M, Tonevitsky A, Schumacher U, Maltseva D, Wicklein D, Lange T
MOL ONCOL. 2024;18(1):62-90.

ALDH1A1 drives prostate cancer metastases and radioresistance by interplay with AR- and RAR-dependent transcription
Gorodetska I, Offermann A, Püschel J, Lukiyanchuk V, Gaete D, Kurzyukova A, Freytag V, Haider M, Fjeldbo C, Di Gaetano S, Schwarz F, Patil S, Borkowetz A, Erb H, Baniahmad A, Mircetic J, Lyng H, Löck S, Linge A, Lange T, Knopf F, Wielockx B, Krause M, Perner S, Dubrovska A
THERANOSTICS. 2024;14(2):714-737.

Comparison of ex vivo bioluminescence imaging, Alu-qPCR and histology for the quantification of spontaneous lung and bone metastases in subcutaneous xenograft mouse models
Haider M, Freytag V, Krause L, Spethmann T, Gosau T, Beine M, Knies C, Schröder-Schwarz J, Horn M, Riecken K, Lange T
CLIN EXP METASTAS. 2024 [Epub ahead of print];2024:.

Efficacy of zoledronic acid for the elimination of disseminated tumor cells in a clinically relevant, spontaneously metastatic prostate cancer xenograft model
Böckelmann L, Freytag V, Ahlers A, Maar H, Gosau T, Baranowsky A, Schmitz R, Pantel K, Schumacher U, Haider M, Lange T
BONE. 2023;171:116741.

Tumor cell integrin β4 and tumor stroma E-/P-selectin cooperatively regulate tumor growth in vivo
Genduso S, Freytag V, Schetler D, Kirchner L, Schiecke A, Maar H, Wicklein D, Gebauer F, Bröker K, Stürken C, Milde-Langosch K, Oliveira-Ferrer L, Ricklefs F, Ewald F, Wolters-Eisfeld G, Riecken K, Unrau L, Krause L, Bohnenberger H, Offermann A, Perner S, Sebens S, Lamszus K, Diehl L, Linder S, Jücker M, Schumacher U, Lange T
J HEMATOL ONCOL. 2023;16(1):.

Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22
Giannou A, Kempski J, Shiri A, Lücke J, Zhang T, Zhao L, Zazara D, Cortesi F, Riecken K, Amezcua Vesely M, Low J, Xu H, Kaffe E, Garcia-Perez L, Agalioti T, Yamada Y, Jungraithmayr W, Zigmond E, Karstens K, Steglich B, Wagner J, Konczalla L, Carambia A, Schulze K, von Felden J, May P, Briukhovetska D, Bedke T, Brockmann L, Starzonek S, Lange T, Koch C, Riethdorf S, Pelczar P, Böttcher M, Sabihi M, Huber F, Reeh M, Grass J, Wahib R, Seese H, Stüben B, Fard-Aghaie M, Duprée A, Scognamiglio P, Plitzko G, Meiners J, Soukou S, Wittek A, Manthey C, Maroulis I, Arck P, Perez D, Gao B, Zarogiannis S, Strowig T, Pasqualini R, Arap W, Gosálvez J, Kobold S, Prinz I, Guse A, Tachezy M, Ghadban T, Heumann A, Li J, Melling N, Mann O, Izbicki J, Pantel K, Schumacher U, Lohse A, Flavell R, Gagliani N, Huber S
IMMUNITY. 2023;56(1):125-142.e12.

The chemicals between us: First results of the cluster analyses on anatomy embalming procedures in the German-speaking countries
Kerner A, Biedermann U, Bräuer L, Caspers S, Doll S, Engelhardt M, Filler T, Ghebremedhin E, Gundlach S, Hayn-Leichsenring G, Heermann S, Hettwer-Steeger I, Hiepe L, Hirt B, Hirtler L, Hörmann R, Kulisch C, Lange T, Leube R, Meuser A, Müller-Gerbl M, Nassenstein C, Neckel P, Nimtschke U, Paulsen F, Prescher A, Pretterklieber M, Schliwa S, Schmidt K, Schmiedl A, Schomerus C, Schulze-Tanzil G, Schumacher U, Schumann S, Spindler V, Streicher J, Tschernig T, Unverzagt A, Valentiner U, Viebahn C, Wedel T, Weigner J, Weninger W, Westermann J, Weyers I, Waschke J, Hammer N
ANAT SCI EDUC. 2023;16(5):814-829.

Dynamics of CXCR4 positive circulating tumor cells in prostate cancer patients during radiotherapy
Klusa D, Lohaus F, Franken A, Baumbach M, Cojoc M, Dowling P, Linge A, Offermann A, Löck S, Hušman D, Rivandi M, Polzer B, Freytag V, Lange T, Neubauer H, Kücken M, Perner S, Hölscher T, Dubrovska A, Krause M, Kurth I, Baumann M, Peitzsch C
INT J CANCER. 2023;152(12):2639-2654.

Ex Vivo Model of Neuroblastoma Plasticity
Schäfer P, Muhs S, Turnbull L, Garwal P, Maar H, Yorgan T, Tolosa E, Lange T, Windhorst S
CANCERS. 2023;15(4):.

Identification of potential classes of glycoligands mediating dynamic endothelial adhesion of human tumor cells
Starzonek S, Maar H, Mereiter S, Freytag V, Haider M, Riecken K, Huang Y, Jacob F, Wicklein D, Schumacher U, Lange T
GLYCOBIOLOGY. 2023;33(8):637-650.

Activation of CD44/PAK1/AKT signaling promotes resistance to FGFR1 inhibition in squamous-cell lung cancer
Elakad O, Häupl B, Labitzky V, Yao S, Küffer S, von Hammerstein-Equord A, Danner B, Jücker M, Urlaub H, Lange T, Ströbel P, Oellerich T, Bohnenberger H
NPJ PRECIS ONCOL. 2022;6(1):.

Detection of Spontaneous Bone Metastases of Solid Human Tumor Xenografts in Mice
Freytag V, Valentiner U, Lange T
2022. Bioluminescence. Kim S (eds.). 4. ed. New York, NY: Humana Press, 317-325.

Tumor cell E-selectin ligands determine partialefficacy of bortezomib on spontaneous lung metastasis formation of solid human tumors in vivo
Lange T, Valentiner U, Wicklein D, Maar H, Labitzky V, Ahlers A, Starzonek S, Genduso S, Staffeldt L, Pahlow C, Dück A, Stürken C, Baranowsky A, Bauer A, Bulk E, Schwab A, Riecken K, Börnchen C, Kiefmann R, Abraham V, DeLisser H, Gemoll T, Habermann J, Block A, Pantel K, Schumacher U
MOL THER. 2022;30(4):1536-1552.

Low expression of CD24 is associated with poor survival in colorectal cancer
Nersisyan S, Ahlers A, Lange T, Wicklein D, Galatenko A, Bohnenberger H, Elakad O, Conradi L, Genduso S, Maar H, Schiecke A, Maltseva D, Raygorodskaya M, Makarova J, Schumacher U, Tonevitsky A
BIOCHIMIE. 2022;192:91-101.

CHD1 loss negatively influences metastasis-free survival in R0-resected prostate cancer patients and promotes spontaneous metastasis in vivo
Oh-Hohenhorst S, Tilki D, Ahlers A, Suling A, Hahn O, Tennstedt P, Matuszcak C, Maar H, Labitzky V, Hanika S, Starzonek S, Baumgart S, Johnsen S, Kluth M, Sirma H, Simon R, Sauter G, Huland H, Schumacher U, Lange T
CANCER GENE THER. 2022;29(1):49-61.

Heparan sulfate dependent binding of plasmatic von Willebrand factor to blood circulating melanoma cells attenuates metastasis
Wang Y, Liu X, Obser T, Bauer A, Heyes M, Starzonek S, Zulal M, Opitz K, Ott L, Riethdorf S, Lange T, Pantel K, Bendas G, Schneider S, Kusche-Gullberg M, Gorzelanny C
MATRIX BIOL. 2022;111:76-94.

Procalcitonin Exerts a Mediator Role in Septic Shock Through the Calcitonin Gene-Related Peptide Receptor
Baranowsky A, Appelt J, Kleber C, Lange T, Ludewig P, Jahn D, Pandey P, Keller D, Rose T, Schetler D, Braumüller S, Huber-Lang M, Tsitsilonis S, Yorgan T, Frosch K, Amling M, Schinke T, Keller J
CRIT CARE MED. 2021;49(1):e41-e52.

Analyzing tyrosine kinase activity in head and neck cancer by functional kinomics: Identification of hyperactivated Src-family kinases as prognostic markers and potential targets
Bußmann L, Hoffer K, von Bargen C, Droste C, Lange T, Kemmling J, Schröder-Schwarz J, Vu A, Akingunsade L, Nollau P, Rangarajan S, de Wijn R, Oetting A, Müller C, Böckelmann L, Zech H, Berger J, Möckelmann N, Busch C, Böttcher A, Gatzemeier F, Klinghammer K, Simnica D, Binder M, Struve N, Rieckmann T, Schumacher U, Clauditz T, Betz C, Petersen C, Rothkamm K, Münscher A, Kriegs M
INT J CANCER. 2021;149(5):1166 - 1180.

The Role of Platelet Cell Surface P-Selectin for the Direct Platelet-Tumor Cell Contact During Metastasis Formation in Human Tumors
Fabricius H, Starzonek S, Lange T
FRONT ONCOL. 2021;11:642761.

Knockdown of AKT3 Activates HER2 and DDR Kinases in Bone-Seeking Breast Cancer Cells, Promotes Metastasis In Vivo and Attenuates the TGFβ/CTGF Axis
Hinz N, Baranowsky A, Horn M, Kriegs M, Sibbertsen F, Smit D, Clezardin P, Lange T, Schinke T, Jücker M
CELLS-BASEL. 2021;10(2):.

Site-specific N-glycosylation of integrin α2 mediates collagen-dependent cell survival
Huang Y, Liang C, Labitzky V, Ritz D, Oliveira T, Cumin C, Estermann M, Lange T, Everest-Dass A, Jacob F
ISCIENCE. 2021;24(10):.

Integrin alpha-V is an important driver in pancreatic adenocarcinoma progression
Kemper M, Schiecke A, Maar H, Nikulin S, Poloznikov A, Galatenko V, Tachezy M, Gebauer F, Lange T, Riecken K, Tonevitsky A, Aigner A, Izbicki J, Schumacher U, Wicklein D
J EXP CLIN CANC RES. 2021;40(1):214.

GLS-driven glutamine catabolism contributes to prostate cancer radiosensitivity by regulating the redox state, stemness and ATG5-mediated autophagy
Mukha A, Kahya U, Linge A, Chen O, Löck S, Lukiyanchuk V, Richter S, Alves T, Peitzsch M, Telychko V, Skvortsov S, Negro G, Aschenbrenner B, Skvortsova I, Mirtschink P, Lohaus F, Hölscher T, Neubauer H, Rivandi M, Labitzky V, Lange T, Franken A, Behrens B, Stoecklein N, Toma M, Sommer U, Zschaeck S, Rehm M, Eisenhofer G, Schwager C, Abdollahi A, Groeben C, Kunz-Schughart L, Baretton G, Baumann M, Krause M, Peitzsch C, Dubrovska A
THERANOSTICS. 2021;11(16):7844-7868.

Role of Metastasis-Related microRNAs in Prostate Cancer Progression and Treatment
Oh-Hohenhorst S, Lange T
CANCERS. 2021;13(17):.

Opposing prognostic relevance of junction plakoglobin in distinct prostate cancer patient subsets
Spethmann T, Böckelmann L, Labitzky V, Ahlers A, Schröder-Schwarz J, Bonk S, Simon R, Sauter G, Huland H, Kypta R, Schumacher U, Lange T
MOL ONCOL. 2021;15(7):1956-1969.

The initial engraftment of tumor cells is critical for the future growth pattern: a mathematical study based on simulations and animal experiments
Hoffmann B, Lange T, Labitzky V, Riecken K, Wree A, Schumacher U, Wedemann G
BMC CANCER. 2020;20(1):524.

Modeling Spontaneous Bone Metastasis Formation of Solid Human Tumor Xenografts in Mice
Labitzky V, Baranowsky A, Maar H, Hanika S, Starzonek S, Ahlers A, Stübke K, Koziolek E, Heine M, Schäfer P, Windhorst S, Jücker M, Riecken K, Amling M, Schinke T, Schumacher U, Valentiner U, Lange T
CANCERS. 2020;12(2):.

Xenograft-derived mRNA/miR and protein interaction networks of systemic dissemination in human prostate cancer
Lange T, Samatov T, Galatenko V, Steffen P, von Kriegstein H, Spethmann T, Wicklein D, Maar H, Kupfernagel K, Labitzky V, Hanika S, Starzonek S, Ahlers A, Riecken K, Simon R, Polonski A, Sauter G, Schlomm T, Huland H, Johnsen S, Schlüter H, Tonevitsky A, Schumacher U
EUR J CANCER. 2020;137:93-107.

Glioma escape signature and clonal development under immune pressure
Maire C, Mohme M, Bockmayr M, Fita K, Riecken K, Börnigen D, Alawi M, Failla A, Kolbe K, Zapf S, Holz M, Neumann K, Dührsen L, Lange T, Fehse B, Westphal M, Lamszus K
J CLIN INVEST. 2020;130(10):5257-5271.

Systematic analysis of the human tumor cell binding to human vs. murine E- and P-selectin under static vs. dynamic conditions
Starzonek S, Maar H, Labitzky V, Wicklein D, Rossdam C, Buettner F, Wolters-Eisfeld G, Guengoer C, Wagener C, Schumacher U, Lange T
GLYCOBIOLOGY. 2020;30(9):695-709.

A functional ex vivo assay to detect PARP1-EJ repair and radiosensitization by PARP-inhibitor in prostate cancer
Köcher S, Beyer B, Lange T, Nordquist L, Volquardsen J, Burdak-Rothkamm S, Schlomm T, Petersen C, Rothkamm K, Mansour W
INT J CANCER. 2019;144(7):1685-1696.

Probennahme per Laserablation von Krebsgeweben für Proteomics
Lange T, Schlüter H
BIOspektrum. 2019;25(1):32-34.

Effect of the actin- and calcium-regulating activities of ITPKB on the metastatic potential of lung cancer cells
Bäder S, Glaubke E, Grüb S, Muhs S, Wellbrock J, Nalaskowski M, Lange T, Windhorst S
BIOCHEM J. 2018;475(12):2057-2071.

Knockdown of L1CAM significantly reduces metastasis in a xenograft model of human melanoma: L1CAM is a potential target for anti-melanoma therapy
Ernst A, Putscher A, Samatov T, Suling A, Galatenko V, Shkurnikov M, Knyazev E, Tonevitsky A, Haalck T, Lange T, Maar H, Schröder-Schwarz J, Riecken K, Schumacher U, Wicklein D
PLOS ONE. 2018;13(2):e0192525.

Locally Ablative Radiation Therapy of a Primary Human Small Cell Lung Cancer Tumor Decreases the Number of Spontaneous Metastases in Two Xenograft Models
Frenzel T, Siekmann J, Grohmann C, Valentiner U, Schmitz R, Riecken K, Fehse B, Schumacher U, Lange T, Krüll A
INT J RADIAT ONCOL. 2018;100(4):1044-1056.

Differential Proteome Analysis of Human Neuroblastoma Xenograft Primary Tumors and Matched Spontaneous Distant Metastases
Hänel L, Gosau T, Maar H, Valentiner U, Schumacher U, Riecken K, Windhorst S, Hansen N, Heikaus L, Wurlitzer M, Nolte I, Schlüter H, Lange T
SCI REP-UK. 2018;8(1):13986.

Development and Characterization of a Spontaneously Metastatic Patient-Derived Xenograft Model of Human Prostate Cancer
Lange T, Oh-Hohenhorst S, Joosse S, Pantel K, Hahn O, Gosau T, Dyshlovoy S, Wellbrock J, Feldhaus S, Maar H, Gehrcke R, Kluth M, Simon R, Schlomm T, Huland H, Schumacher U
SCI REP-UK. 2018;8:17535.

Clinical relevance of cytoskeleton associated proteins for ovarian cancer
Schiewek J, Schumacher U, Lange T, Joosse S, Wikman H, Pantel K, Mikhaylova M, Kneussel M, Linder S, Schmalfeldt B, Oliveira-Ferrer L, Windhorst S
J CANCER RES CLIN. 2018;144(11):2195-2205.

CEACAM1 promotes melanoma metastasis and is involved in the regulation of the EMT associated gene network in melanoma cells
Wicklein D, Otto B, Suling A, Elies E, Lüers G, Lange T, Feldhaus S, Maar H, Schröder-Schwarz J, Brunner G, Wagener C, Schumacher U
SCI REP-UK. 2018;8:11893.

Strong fascin expression promotes metastasis independent of its F-actin bundling activity
Heinz L, Muhs S, Schiewek J, Grüb S, Nalaskowski M, Lin Y, Wikman H, Oliveira-Ferrer L, Lange T, Wellbrock J, Konietzny A, Mikhaylova M, Windhorst S
ONCOTARGET. 2017;8(66):110077-110091.

Selection and Characterization of an α6β4 Integrin blocking DNA Aptamer
Berg K, Lange T, Mittelberger F, Schumacher U, Hahn U
MOL THER-NUCL ACIDS. 2016;5:e294.

Marine compound rhizochalinin shows high in vitro and in vivo efficacy in castration resistant prostate cancer
Dyshlovoy S, Otte K, Alsdorf W, Hauschild J, Lange T, Venz S, Bauer C, Bähring R, Amann K, Mandanchi R, Schumacher U, Schröder-Schwarz J, Makarieva T, Guzii A, Tabakmakher K, Fedorov S, Shubina L, Kasheverov I, Ehmke H, Steuber T, Stonik V, Bokemeyer C, Honecker F, von Amsberg G
ONCOTARGET. 2016;7(43):69703 - 69717.

Downregulation of AKT3 Increases Migration and Metastasis in Triple Negative Breast Cancer Cells by Upregulating S100A4
Grottke A, Ewald F, Lange T, Nörz D, Herzberger C, Bach J, Grabinski N, Gräser L, Höppner F, Nashan B, Schumacher U, Jücker M
PLOS ONE. 2016;11(1):e0146370.

Intracellular and extracellular microRNA: An update on localization and biological role
Makarova J, Shkurnikov M, Wicklein D, Lange T, Samatov T, Turchinovich A, Tonevitsky A
PROG HISTOCHEM CYTO. 2016;51(3-4):33-49.

Drosophila homologue of Diaphanous 1 (DIAPH1) controls the metastatic potential of colon cancer cells by regulating microtubule-dependent adhesion
Lin Y, Bhuwania R, Gromova K, Failla A, Lange T, Riecken K, Linder S, Kneussel M, Izbicki J, Windhorst S
ONCOTARGET. 2015;6(21):18577-89.

SDA, a DNA aptamer inhibiting E- and P-selectin mediated adhesion of cancer and leukemia cells, the first and pivotal step in transendothelial migration during metastasis formation
Faryammanesh R, Lange T, Magbanua E, Haas S, Meyer C, Wicklein D, Schumacher U, Hahn U
PLOS ONE. 2014;9(4):e93173.

Aberrant presentation of HPA-reactive carbohydrates implies Selectin-independent metastasis formation in human prostate cancer
Lange T, Kupfernagel M, Wicklein D, Gebauer F, Maar H, Brügge K, Müller I, Simon R, Schlomm T, Sauter G, Schumacher U
CLIN CANCER RES. 2014;20(7):1791-802.

Importance of altered glycoprotein-bound N- and O-glycans for epithelial-to-mesenchymal transition and adhesion of cancer cells
Lange T, Samatov T, Tonevitsky A, Schumacher U
CARBOHYD RES. 2014;389:39-45.

Expression of DIAPH1 is up-regulated in colorectal cancer and its down-regulation strongly reduces the metastatic capacity of colon carcinoma cells
Lin Y, Izbicki J, König A, Habermann J, Blechner C, Lange T, Schumacher U, Windhorst S
INT J CANCER. 2014;134(7):1571-82.

Expression of the coxsackie adenovirus receptor in neuroendocrine lung cancers and its implications for oncolytic adenoviral infection.
Wunder T, Schmid K, Wicklein D, Groitl P, Dobner T, Lange T, Anders M, Schumacher U
CANCER GENE THER. 2013;20(1):25-32.

Divergent resorbability and effects on osteoclast formation of commonly used bone substitutes in a human in vitro-assay.
Keller J, Brink S, Busse B, Schilling A, Schinke T, Amling M, Lange T
PLOS ONE. 2012;7(10):46757.

Human prostate cancer in a clinically relevant xenograft mouse model: identification of β(1,6)-branched oligosaccharides as a marker of tumor progression.
Lange T, Ullrich S, Müller I, Nentwich M, Stübke K, Feldhaus S, Knies C, Hellwinkel O, Vessella R, Abramjuk C, Anders M, Schröder-Schwarz J, Schlomm T, Huland H, Sauter G, Schumacher U
CLIN CANCER RES. 2012;18(5):1364-1373.

p65-Dependent production of interleukin-1β by osteolytic prostate cancer cells causes an induction of chemokine expression in osteoblasts.
Schulze J, Riecken K, Baranowsky A, Streichert T, Lange T, Spiro A, Albers J, Seitz S, Zustin J, Amling M, Fehse B, Schinke T
CANCER LETT. 2012;317(1):106-113.

Neuronal differentiation by indomethacin and IBMX inhibits proliferation of small cell lung cancer cells in vitro.
Lange A, Gustke H, Glassmeier G, Heine M, Zangemeister-Wittke U, Schwarz J, Schumacher U, Lange T
LUNG CANCER. 2011;74(2):178-187.

Trastuzumab has anti-metastatic and anti-angiogenic activity in a spontaneous metastasis xenograft model of esophageal adenocarcinoma.
Lange T, Nentwich M, Lueth M, Yekebas E, Schumacher U
CANCER LETT. 2011;308(1):54-61.

Size dependent induction of proinflammatory cytokines and cytotoxicity of particulate beta-tricalciumphosphate in vitro.
Lange T, Schilling A, Peters F, Mujas J, Wicklein D, Amling M
BIOMATERIALS. 2011;32(17):4067-4075.

Adhesion of small cell lung cancer cells to E- and P-selectin under physiological flow conditions: implications for metastasis formation.
Richter U, Schröder C, Wicklein D, Lange T, Geleff S, Dippel V, Schumacher U, Klutmann S
HISTOCHEM CELL BIOL. 2011;135(5):499-512.

Proinflammatory and osteoclastogenic effects of beta-tricalciumphosphate and hydroxyapatite particles on human mononuclear cells in vitro.
Lange T, Schilling A, Peters F, Haag F, Morlock M, Rueger J, Amling M
BIOMATERIALS. 2009;30(29):5312-5318.

Gap junctional communication in human osteoclasts in vitro and in vivo.
Schilling A, Filke S, Lange T, Gebauer M, Brink S, Baranowsky A, Zustin J, Amling M
J CELL MOL MED. 2008;12(6):2497-2504.

Letzte Aktualisierung aus dem FIS: 28.03.2024 - 04:44 Uhr