Dr. rer. nat.
Hongying Lin
  • Scientist
  • Technical employee
Working area



N45 Rothe-Geussenhainer-Haus, 2nd Floor, Room number 217
Chinese (Mother tongue)



Characterization of the substrate specificity of the inositol 5-phosphatase SHIP1
Nelson N, Wundenberg T, Lin H, Rehbach C, Horn S, Windhorst S, Jücker M
BIOCHEM BIOPH RES CO. 2020;524(2):366-370.


Inositol hexakisphosphate increases the size of platelet aggregates
Brehm M, Klemm U, Rehbach C, Erdmann N, Kolšek K, Lin H, Aponte-Santamaría C, Gräter F, Rauch B, Riley A, Mayr G, Potter B, Windhorst S
BIOCHEM PHARMACOL. 2019;161:14-25.

A novel 6-pyrophosphorylating IP6 kinase (IP6-6K) discovered in the protozoon Trichomonas vaginalis
Wundenberg T, Nalaskowski M, Löser B, Fanick W, Hackl T, Fürnkranz U, Rehbach C, Lin H, Mayr G
MOL BIOCHEM PARASIT. 2019;227:53-63.


The new InsP3Kinase inhibitor BIP-4 is competitive to InsP3 and blocks proliferation and adhesion of lung cancer cells
Schröder D, Tödter K, Gonzalez B, Franco-Echevarría E, Rohaly G, Blechner C, Lin H, Mayr G, Windhorst S
BIOCHEM PHARMACOL. 2015;96(2):143-50.


Cellular internalisation of an inositol phosphate visualised by using fluorescent InsP5
Riley A, Windhorst S, Lin H, Potter B
CHEMBIOCHEM. 2014;15(1):57-67.

Discovery of InsP6-kinases as InsP6 dephosphorylating enzymes provides a new mechanism of cytosolic InsP6 degradation driven by the cellular ATP/ADP ratio
Wundenberg T, Grabinski N, Lin H, Mayr G
BIOCHEM J. 2014.


Malignant H1299 tumour cells preferentially internalize iron-bound inositol hexakisphosphate
Helmis C, Blechner C, Lin H, Schweizer M, Mayr G, Nielsen P, Windhorst S
BIOSCIENCE REP . 2013;33(5):.

Tumour cells can employ extracellular Ins(1,2,3,4,5,6)P(6) and multiple inositol-polyphosphate phosphatase 1 (MINPP1) dephosphorylation to improve their proliferation
Windhorst S, Lin H, Blechner C, Fanick W, Brandt L, Brehm M, Mayr G
BIOCHEM J. 2013;450(1):115-25.


A novel Entamoeba histolytica inositol phosphate kinase catalyzes the formation of 5PP-Ins(1,2,3,4,6)P(5)
Löser B, Nalaskowski M, Fanick W, Lin H, Tannich E, Mayr G
MOL BIOCHEM PARASIT. 2012;181(1):49-52.

A Plasmodium multi-domain protein possesses multiple inositol phosphate kinase activities.
Stritzke C, Nalaskowski M, Fanick W, Lin H, Mayr G
MOL BIOCHEM PARASIT. 2012;186(2):134-138.

Inositol-1,4,5-trisphosphate 3-kinase A regulates dendritic morphology and shapes synaptic Ca2+ transients.
Windhorst S, Minge D, Bähring R, Hüser S, Schob C, Blechner C, Lin H, Mayr G, Kindler S
CELL SIGNAL. 2012;24(3):750-757.


Human inositol 1,4,5-trisphosphate 3-kinase isoform B (IP3KB) is a nucleocytoplasmic shuttling protein specifically enriched at cortical actin filaments and at invaginations of the nuclear envelope.
Nalaskowski M, Fliegert R, Ernst O, Brehm M, Fanick W, Windhorst S, Lin H, Giehler S, Hein J, Lin Y, Mayr G
J BIOL CHEM. 2011;286(6):4500-4510.

Human regulatory T cells rapidly suppress T cell receptor-induced Ca(2+), NF-κB, and NFAT signaling in conventional T cells.
Schmidt A, Oberle N, Weiss E, Vobis D, Frischbutter S, Baumgrass R, Falk C, Haag M, Brügger B, Lin H, Mayr G, Reichardt P, Gunzer M, Suri-Payer E, Krammer P
SCI SIGNAL. 2011;4(204):90.


Quality control of inclusion bodies in Escherichia coli.
Jürgen B, Breitenstein A, Urlacher V, Büttner K, Lin H, Hecker M, Schweder T, Neubauer P
MICROB CELL FACT. 2010;9:41.

Synthesis and nonradioactive micro-analysis of diphosphoinositol phosphates by HPLC with postcolumn complexometry.
Lin H, Lindner K, Mayr G
Methods Mol Biol. 2010;645:103-122.

Inositol-1,4,5-trisphosphate-3-kinase-A is a new cell motility-promoting protein that increases the metastatic potential of tumour cells by two functional activities.
Windhorst S, Fliegert R, Blechner C, Möllmann K, Hosseini Z, Guenther T, Eiben M, Chang L, Lin H, Fanick W, Schumacher U, Brandt B, Mayr G
J BIOL CHEM. 2010;285(8):5541-5554.


Structural analysis and detection of biological inositol pyrophosphates reveals that the VIP/PPIP5K family are 1/3-kinases.
Lin H, Fridy P, Ribeiro A, Choi J, Barma D, Vogel G, Falck J, Shears S, York J, Mayr G
J BIOL CHEM. 2009;284(3):1863-1872.

Phosphoinositide and inositol phosphate analysis in lymphocyte activation.
Sauer K, Huang Y, Lin H, Sandberg M, Mayr G
Curr Protoc Immunol. 2009;11:1.


Chronic lithium salt treatment reduces CRE/CREB-directed gene transcription and reverses its upregulation by chronic psychosocial stress in transgenic reporter gene mice.
Böer U, Cierny I, Krause D, Heinrich A, Lin H, Mayr G, Hiemke C, Knepel W
NEUROPSYCHOPHARMACOL. 2008;33(10):2407-2415.

Ins(1,4,5)P3 3-kinase-A overexpression induces cytoskeletal reorganization via a kinase-independent mechanism.
Windhorst S, Blechner C, Lin H, Elling C, Nalaskowski M, Kirchberger T, Guse A, Mayr G
BIOCHEM J. 2008;414(3):407-417.


Intracellular localization of human Ins(1,3,4,5,6)P5 2-kinase.
Brehm M, Schenk T, Zhou X, Fanick W, Lin H, Windhorst S, Nalaskowski M, Kobras M, Shears S, Mayr G
BIOCHEM J. 2007;408(3):335-345.


Aha1 competes with Hop, p50 and p23 for binding to the molecular chaperone Hsp90 and contributes to kinase and hormone receptor activation.
Harst A, Lin H, Obermann Wolfgang M
BIOCHEM J. 2005;387(3):789-796.


Change of extracellular cAMP concentration is a sensitive reporter for bacterial fitness in high-cell-density cultures of Escherichia coli.
Lin H, Hoffmann F, Rozkov A, Enfors S, Rinas U, Neubauer P
BIOTECHNOL BIOENG. 2004;87(5):602-613.


Activated G alpha q inhibits p110 alpha phosphatidylinositol 3-kinase and Akt.
Ballou L, Lin H, Fan G, Jiang Y, Lin R
J BIOL CHEM. 2003;278(26):23472-23479.

Stimulation of the alpha1A adrenergic receptor inhibits PDGF-induced PDGF beta receptor Tyr751 phosphorylation and PI 3-kinase activation.
Lin H, Ballou L, Lin R
FEBS LETT. 2003;540(1-3):106-110.

Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone.
Lotz Gregor P, Lin H, Harst A, Obermann Wolfgang M
J BIOL CHEM. 2003;278(19):17228-17235.

Metabolic load of recombinant protein production: inhibition of cellular capacities for glucose uptake and respiration after induction of a heterologous gene in Escherichia coli.
Neubauer P, Lin H, Mathiszik B
BIOTECHNOL BIOENG. 2003;83(1):53-64.


Role of the general stress response during strong overexpression of a heterologous gene in Escherichia coli.
Schweder T, Lin H, Jürgen B, Breitenstein A, Riemschneider S, Khalameyzer V, Gupta A, Büttner K, Neubauer P
APPL MICROBIOL BIOT. 2002;58(3):330-337.


Dual regulation of glycogen synthase kinase-3beta by the alpha1A-adrenergic receptor
Ballou L, Tian P, Lin H, Jiang Y, Lin R
J BIOL CHEM. 2001;276(44):40910-6.

Physiological responses to mixing in large scale bioreactors.
Enfors S, Jahic M, Rozkov A, Xu B, Hecker M, Jürgen B, Krüger E, Schweder T, Hamer G, O'Beirne D, Noisommit-Rizzi N, Reuss M, Boone L, Hewitt C, McFarlane C, Nienow A, Kovacs T, Trägårdh C, Fuchs L, Revstedt J, Friberg P, Hjertager B, Blomsten G, Skogman H, Hjort S, Hoeks F, Lin H, Neubauer P, van der Lans R, Luyben K, Vrabel P, Manelius A
J BIOTECHNOL. 2001;85(2):175-185.

Cellular Responses to Strong Overexpression of Recombinant Genes in Escherichia Coli
Lin H, Hanschke , Nicklisch , Riemschneider , Meyer , Gupta , Neubauer P
2001. Recombinant Protein Production with Prokaryotic and Eukaryotic Cells. A Comparative View on Host Physiology. Springer Netherlands, .

Determination of the maximum specific uptake capacities for glucose and oxygen in glucose-limited fed-batch cultivations of Escherichia coli.
Lin H, Mathiszik B, Xu B, Enfors S, Neubauer P
BIOTECHNOL BIOENG. 2001;73(5):347-357.


Monitoring of genes that respond to overproduction of an insoluble recombinant protein in Escherichia coli glucose-limited fed-batch fermentations.
Jürgen B, Lin H, Riemschneider S, Scharf C, Neubauer P, Schmid R, Hecker M, Schweder T
BIOTECHNOL BIOENG. 2000;70(2):217-224.

Influence of controlled glucose oscillations on a fed-batch process of recombinant Escherichia coli.
Lin H, Neubauer P
J BIOTECHNOL. 2000;79(1):27-37.


Growth rate related concentration changes of the starvation response regulators sigmaS and ppGpp in glucose-limited fed-batch and continuous cultures of Escherichia coli.
Teich A, Meyer S, Lin H, Andersson L, Enfors S, Neubauer P
BIOTECHNOL PROGR. 1999;15(1):123-129.


Amplification of ColE1 related plasmids in recombinant cultures of Escherichia coli after IPTG induction.
Teich A, Lin H, Andersson L, Meyer S, Neubauer P
J BIOTECHNOL. 1998;64(2-3):197-210.

Letzte Aktualisierung aus dem FIS: 01.06.2020 - 06:32 Uhr