Section Hemophilia

Outpatient Clinic for Coagulation Disorders and Hemophilia Center

The main focus of our outpatient clinic is the diagnosis and therapy of coagulation disorders. This includes thrombophilia (increased risk of thrombosis) and hemorrhagic diathesis (increased susceptibility to bleeding).

The hemophilia center serves to provide highly specialized care for patients with diagnosed hemophilia (hemophilia A or B), von Willebrand syndrome, or other rare hemostasis disorders.

In addition, the Adult Hemophilia Center is organized together with the Hemophilia Center for Children and Adolescents and the Department of Orthopedics in the Center for Rare Diseases of the UKE as a B-Center (Center for Hemophilia and Orthopedic Secondary Diseases, CHOD).


  • The outpatient clinic for coagulation disorders

    The outpatient clinic for coagulation disorders is the central contact point for the medical evaluation of thrombotic or bleeding tendencies. We offer the following range of services:

    Thrombotic Tendency

    • Laboratory diagnostic evaluation of congenital (e.g. Factor V Leiden Thrombophilia and Prothrombin Mutation G20210A) and acquired prothrombotic coagulation disorders (e.g. antiphospholipid syndrome)
    • Individual counseling regarding a risk adapted thromboprophylaxis for patients with congenital thrombophilia
    • Recommendations on the type and the duration of anticoagulation after venous or arterial thromboembolism
    • Therapy monitoring (INR Monitoring) in patients undergoing oral anticoagulation with vitamin K antagonists (e.g. Marcumar®)
    • Monitoring an antiaggregation therapy with Acetylsalicylic acid (ASA) or P2Y12-antagonists (e.g. Clopidogrel)
    • Concrete recommendations for bridging an antithrombotic therapy in the course of invasive procedures or surgery (Bridging)
    • Recommendations regarding indication, application and side-effect profile of the new oral thrombin and factor Xa-inhibitors
    • Support and care for pregnant women with increased risk of abortion or vascular risk factors
    Bleeding Tendency

    • Clinical and laboratory diagnosis of unclear bleeding tendency
    • Further diagnostic workup of abnormal coagulation parameters (e.g. in pre-operative routine laboratory tests)
    • Diagnostics and therapy of secondary von-Willebrand syndrome and acquired autoimmune hemophilia (Hemmkörperhämophilie)
    • Individual recommendations for factor substitution and for supportive hemostaseologic therapy in surgery or invasive procedures
    • Review of the effectiveness and tolerability of DDAVP (desmopressin) in patients with von-Willebrand Syndrome or mild hemophilia

    Consultation hours:
    Monday to Friday from 8:30 a.m. to 1:00 p.m.

    Phone: 040-7410-52453 (Monday to Friday from 8:00 a.m. to 4.00 p.m. )

    Building O24, 1. OG (Station C1b), Martinistr. 52,
    20246 Hamburg
    Fax: +49 (0) 40 7410 - 55193

    Please remember to bring your health insurance card and all treatment-relevant documents (e.g. doctor´s letters, laboratory reports, ultrasound and CT findings).

  • Hemophilia Center

    In the hemophilia center, a highly specialized team of doctors and nursing staff treats patients with congenital or acquired bleeding tendencies.

    We specialize in the treatment of the following diseases:

    • Classic hemophilia (hemophilia A and B)
    • Carriers for Hemophilia A or B
    • Von-Willebrand syndrome
    • Rare factor deficiency diseases e.g. Deficiency of factor I, II, V, VII, X, XI, and XIII
    • Thrombocytopathies
    • Acquired autoimmune hemophilia (Hemmkörperhemophilie)

    As a Comprehensive Care Center (CCC) and designated European CCC as well as one of the largest treatment centers in Northern Germany, the Hemophilia Center offers comprehensive and individual treatment in close cooperation with colleagues in the Department for Pediatric Hematology and Oncology.

    We also maintain good and trusting collaborations with other departments.

    Our services include:

    • Appropriate therapy with coagulation factor concentrates for the treatment of bleeding and hemorrhage prophylaxis
    • 24-hour availability
    • Competence of specialists and continuity in the interdisciplinary cooperation with other departments
      • Pediatric hematology and oncology
      • Orthopedics at the UKE and in Bad Bramstedt
      • Laboratory Medicine
      • Department for Infectious Diseases
      • (e.g. Hepatitis and HIV Outpatient Clinic)
      • Oral and Maxillofacial Surgery
      • General Surgery
      • Otolaryngology
      • Obstetrics and Gynecology
    • Counseling specifically for hemophilia in special circumstances
      • e.g. o Desire to have children / pregnancy
      • Career choice / occupational disability
    • Disease-specific genetic counseling
    • Pain management
    • A comprehensive medical examination for the early detection and treatment of hemophilia-related diseases (e.g. hemophilic arthropathy, complications from infections) and age-related concomitant diseases (e.g., arterial hypertension, diabetes mellitus) at least once a year
    • Enhanced co-supervision of inpatients
    • Diagnostics and therapy of orthopedic secondary diseases in the Center for Hemophilia and Orthopedic Secondary Diseases (CHOD)

  • Center for Hemophilia and Orthopedic Secondary Diseases (CHOD)

    The Hemophilia Center for Adults and the Hemophilia Center for Children and Adolescents are joined by the Department of Orthopedics in the Center for Rare Diseases in the UKE and is organized as a B-Center (Center for Hemophilia and Orthopedic Secondary Diseases, CHOD).

    By implementing the following structures we have strongly improved the quality of care of patients with hemophilia, von-Willebrand Syndrome, or other rare hemostasis disorders:

    • Interdisciplinary orthopedic-hemostaseologic consultation sessions with the Hemophilia Centers for Children and Adolescents or Adults and the Department of Orthopedics
    • Establishment of a continuous clinical orthopedic and physiotherapy care of hemophilia patients for the prevention of secondary orthopedic disorders
    • Close cooperation for the indication of medical treatment, planning, and implementation of orthopedic surgery, including coagulation management and after-care
    • Development of new therapeutic models by interdisciplinary networking of clinical practice and research
    • Cooperation with medical associations, self-help groups, and other centers for rare diseases

    Physicians and Staff of B-Center for Rare Diseases:

    Hemophilia Center for Adults, II. Medical Clinic and Policlinic

    Hemophilia Center for Children and Adolescents and Department for Pediatric Hematology and Oncology

    • Dr. med. Johanna Schrum
    • Dr. med. Wolf Hassenpflug (Deputy Spokesperson for the B-Center)
    • Beate Fischer (Hemophilia Assistant)

    Department of Orthopedics at the University Medical Center Hamburg-Eppendorf and in Clinic Bad Bramstedt GmbH

    • Prof. Dr. med. Wolfgang Rüther
    • Prof. Dr. med. Andreas Neemeier
    • Andre Strahl

    Appointments for interdisciplinary orthopedic consultations:

    For adults:

    Jessica Gäßler (Hemophilia Assistant): +49 (0) 40 7410 - 56585 or +49 (0) 40 7410 - 52453

    For children and adolescents:

    Beate Fischer (Hemophilia Assistant): +49 (0) 40 7410 - 53796 or 0152 - 2281 7811