UKE - UCCS - Working Group

Working Group Twerenbold

Name: Prof. Dr. Raphael Twerenbold
Clinic/Institute: Department of Cardiology
Email: r.twerenbold@uke.de
Phone: +49 (0) 40 7410 - 58012

Research Focus and Main research questions

Our research group has been established in 2021 to explore the utility of biomarkers and genomics in cardiovascular health and disease.

A wide range of biomarkers, not limited to circulating molecules in the blood but also integrating vital signs, ECG and imaging data, are linked with cardiovascular disease and future cardiovascular events. We aim to assess the diagnostic and prognostic utility of established and emerging biomarkers in large-scale clinical and epidemiological datasets. With the aid of advanced statistical models including machine-based learning, biomarkers will be considered in a holistic approach in order to enable best incremental value in clinical practice.

As a center piece of this research group, whole genome sequencing data will be obtained from 8‘000 apparently healthy individuals from the Hamburg City Health Study (HCHS) and 1‘000 patients with cardiovascular disease. This unique dataset with most detailed phenotyping will provide the basis to study the impact of genomics on cardiovascular health, test for risk prediction models and identify novel therapeutic targets.

Methods
Publications
Recent Funding

Methods
Methods:
- translational and clinical research
- collaborations with global research networks
- comprehensive statistical analyses within large-scale local, national and international clinical and epidemiological datasets
- derivation and validation of diagnostic and prognostic algorithms
- application of advanced statistical prediction models including machine-based learning
- analyses of whole-genome sequencing data combined with most detailed phenotype data

Publications

Publications:
1. Neumann*, Twerenbold*, Ojeda, Sorensen, Chapman, Shah, Anand, Boeddinghaus, Nestelberger, Badertscher, Mokhtari, Pickering, Troughton, Greenslade, Parsonage, Mueller-Hennessen, Gori, Jernberg, Morris, Liebetrau, Hamm, Katus, Munzel, Landmesser, Salomaa, Iacoviello, Ferrario, Giampaoli, Kee, Thorand, Peters, Borchini, Jorgensen, Soderberg, Sans, Tunstall-Pedoe, Kuulasmaa, Renne, Lackner, Worster, Body, Ekelund, Kavsak, Keller, Lindahl, Wild, Giannitsis, Than, Cullen, Mills, Mueller, Zeller, Westermann, Blankenberg. Application of High-Sensitivity Troponin in Suspected Myocardial Infarction. N Engl J Med 2019.
2. Twerenbold, Costabel, Nestelberger, Campos, Wussler, Arbucci, Cortes, Boeddinghaus, Baumgartner, Nickel, Bingisser, Badertscher, Puelacher, du Fay de Lavallaz, Wildi, Rubini Gimenez, Walter, Meier, Hafner, Lopez Ayala, Lohrmann, Troester, Koechlin, Zimmermann, Gualandro, Reichlin, Lambardi, Resi, Alves de Lima, Trivi, Mueller. Outcome of Applying the ESC 0/1-hour Algorithm in Patients With Suspected Myocardial Infarction. J Am Coll Cardiol 2019.
3. Twerenbold, Badertscher, Boeddinghaus, Nestelberger, Wildi, Puelacher, Sabti, Rubini, Tschirky, du Fay de Lavallaz, Kozhuharov, Sazgary, Mueller, Breidthardt, Strebel, Flores Widmer, Shrestha, Miro, Sanchez , Morawiec, Parenica, Geigy, Keller, Rentsch, von Eckardstein, Osswald, Reichlin, Mueller. 0/1-Hour Triage Algorithm for Myocardial Infarction in Patients With Renal Dysfunction. Circulation 2018.
4. Twerenbold*, Neumann*, Sorensen, Ojeda, Karakas, Boeddinghaus, Nestelberger, Badertscher, Rubini, Puelacher, Wildi, Kozhuharov, Breitenbuecher, Biskup, du Fay de Lavallaz, Flores, Wussler, Miro, Sanchez, Morawiec, Parenica, Geigy, Keller, Zeller, Reichlin, Blankenberg, Westermann, Mueller. Prospective Validation of the 0/1-h Algorithm for Early Diagnosis of Myocardial Infarction. J Am Coll Cardiol 2018.
5. Kaier*, Twerenbold*, Puelacher, Marjot, Imambaccus, Boeddinghaus, Nestelberger, Badertscher, Sabti, Gimenez, Wildi, Hillinger, Grimm, Loeffel, Shrestha, Widmer, Cupa, Kozhuharov, Miro, Sanchez, Morawiec, Rentsch, Kloos, Osswald, Reichlin, Weber, Marber, Mueller. Direct Comparison of Cardiac Myosin-Binding Protein C With Cardiac Troponins for the Early Diagnosis of Acute Myocardial Infarction. Circulation 2017.
6.Twerenbold, Jaeger, Rubini Giménez, Wildi, Reichlin, Nestelberger, Boeddinghaus, Grimm, Puelacher, Moehring, Pretre ,Schaerli, Campodarve, Rentsch, Steuer, Osswald, Mueller. Impact of high-sensitivity cardiac troponin on use of coronary angiography, cardiac stress testing and time to discharge in suspected acute myocardial infarction. Eur Heart J 2016.

Recent Funding

Recent Funding:
2020: COVIVA | Swiss Heart Foundation |
2020: COVIVA risk | Cardiovasc. Research Found. Basel |
2019: APACE risk | Swiss Heart Foundation |
2018: APACE late | Swiss Heart Foundation |
2016-2018: DEDICATE BM | Swiss National Science Found |