UKE - UCCS - Lemoine

Research Group Lemoine

Autonomic modulation after pulsed-field and thermal ablation

Name: PD Dr. Marc Lemoine
Department/Center/Institute: University Heart and Vascular Center Hamburg (UHZ),
Department of Cardiology
Email: m.lemoine@uke.de

Aim

We aim to understand the differences between pulsed-field and thermal energy sources during ablation of atrial fibrillation and the effect on the cardiac autonomic nervous system with potential consequences to arrhythmia recurrence, heart rate and extracardiac function.

Scope of Research

Pulse-field-ablation • neurocardiac function • atrial fibrillation recurrence

Research Projects

3 year follow-up for AF recurrence in patients undergoing first pumonary vein with pulse-field vs. cryoballoon ablation within the prospective trust registry. The analysis will focus on AF pattern and reconnection pattern.
Autonomic modulation after PFA vs. Cryoballon ablation of atrial fibrillation and the impact on recurrence. This project will focus on parameter for neurocardiac damage (heart rate + HR variability change, S100B biomarker) which might be associated to AF recurrence rate and the impact of autonomic trigger (sympathetic/vagal induced AF) on recurrence rate. Patient with autonomic disorders (vasovagal syncope, functional atrioventricular block, and sinus node dysfunction) will be undergo subgroup analysis.
The impact of VT ablation on ventricular ganglionated plexi is widely unknown. Novel catheter designs (Sphere9) allow deeper lesions and to toggle between radiofrequency and PFA. We will analyze ventricular effective refractory periods, pre- and postprocedural biomarker (S100B) and postprocedural VT/PVC recurrence to evaluate the potential difference oft two energy source.

Key Techniques
Publications
Grants and Awards
Most important collaboration partners

Key Techniques
Key Techniques:
- AF ablation by Cryoballoon / Farapulse / PulseSelect and VT ablation by RF / Sphere9 (PFA/RF)
- AF recurrence (wearable, Holter, telephone interviews)
- Functional analysis of autonomic parameter (Heart rate, HR variability)
- Biomarker analysis
- Engineered heart tissue to model genetic heart disease

Publications

Publications:
Pulsed-field- vs. cryoballoon-based pulmonary vein isolation: lessons from repeat procedures .
Lemoine & Obergassel et al.
Europace. 2024. doi: 10.1093/europace/euae221.
Acute lesion extension following pulmonary vein isolation with two novel single shot devices: Pulsed field ablation versus multielectrode radiofrequency balloon .
My & Lemoine et al.
J Cardiovasc Electrophysiol. 2023 doi: 10.1111/jce.16001.
Pulmonary Vein Isolation by Pulsed-field Ablation Induces Less Neurocardiac Damage Than Cryoballoon Ablation.
Lemoine et al.
Circ Arrhythm Electrophysiol. 2023 doi: 10.1161/CIRCEP.122.011598.
Pulsed-field ablation-based pulmonary vein isolation: acute safety, efficacy and short-term follow-up in a multi-center real world scenario.
Lemoine et al.
Clin Res Cardiol. 2023 doi: 10.1007/s00392-022-02091-2
Cardiac glial cells release neurotrophic S100B upon catheter-based treatment of atrial fibrillation
Scherschel, Lemoine, Meyer et al.;
Science Translational Research 2019; doi: 10.1126/scitranslmed.aav7770

Grants and Awards
Grants/Awards
- Hugo-von-Ziemssen-Posterprice DGK 2024 for Sandro Jäckle
- Jung-Fellowship 2023 for Sandro Jäckle
- Clinician Scientist Programm (UKE)
- Exzellenzprogramm Postdoc-Start-up Grant (DZHK)
- Wilhelm P. Winterstein-Prize (German Heart Foundation)
- Nachwuchsförderung des Forschungsförderungsfonds (UKE)
- Rotation Grant of the German center for Cardiovascular Research (DZHK)
- MD fellowship of the Boeringer-Ingelheim Fonds
- Stipendiary of German National Merit Foundation (Studienstiftung des deutschen Volkes)

Most important collaboration partners
Most important collaboration partners
- Prof. Dr. Metzner and PD Dr. Rillig, UKE - Investigation of new ablation modalities
- Prof. Dr. Kirchhof, UKE – Randomized control trials in patients with atrial fibrillation
- Prof. Dr. Fabritz, UKE – Biomarker analysis and preclinical models - Channelopathies
- Prof. Eschenhagen – PD Dr. Christ - Cellular Electrophysiology – Engineered heart tissue
- Prof. Dr. Patten – Prof. Dr. Carrier – Genetic models for hypertrophic cardiomyopathy
- Prof. Christian Meyer and Dr. Katharina Scherschel (EVK, Düsseldorf) – Autonomic function, mouse models and histological analysis
- Prof. Linz (Maastricht/Kopenhagen), Large animal models – Pulsed-field ablation